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activity;GO:0034185 apolipoprotein binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:1905167 positive regulation of lysosomal protein catabolic process;GO:0006909 phagocytosis;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0006898 receptor-mediated endocytosis;GO:0045807 positive regulation of endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BGJ0-1", "record_type": "protein", "filter_code": "0000000.0000001.000100.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BHK0-1", "uniprot_id": [ { "id": "E1BHK0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BHK0", "type": "external" } ], "mass": 68364.0, "length": 614, "protein_name": "Cholinergic receptor nicotinic alpha 4 subunit", "gene_name": "CHRNA4", "organism": "Bovine", "refseq_name": "neuronal acetylcholine receptor subunit alpha-4 precursor", "refseq_ac": [ { "id": "NP_001179829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179829", "type": "external" } ], "gene_names_uniprotkb": "CHRNA4", "gene_names_refseq": "CHRNA4", "protein_names_uniprotkb": "Cholinergic receptor nicotinic alpha 4 subunit", "protein_names_refseq": "cholinergic receptor, nicotinic, alpha 4 (neuronal); neuronal acetylcholine receptor subunit alpha-4 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:537251); (R-BTA-629587); (R-BTA-629594); (R-BTA-629597)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0140658 ATP-dependent chromatin remodeler activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BHK0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BHR7-1", "uniprot_id": [ { "id": "E1BHR7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BHR7", "type": "external" } ], "mass": 59560.0, "length": 548, "protein_name": "Anti-Muellerian hormone type-2 receptor", "gene_name": "AMHR2", "organism": "Bovine", "refseq_name": "anti-Muellerian hormone type-2 receptor isoform X1", "refseq_ac": [ { "id": "XP_024847474", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847474", "type": "external" } ], "gene_names_uniprotkb": "AMHR2", "gene_names_refseq": "AMHR2", "protein_names_uniprotkb": "Anti-Muellerian hormone type-2 receptor; 2.7.11.30; Anti-Muellerian hormone type II receptor; MIS type II receptor", "protein_names_refseq": "anti-Muellerian hormone type-2 receptor isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-201451)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0042562 hormone binding;GO:0005024 transforming growth factor beta receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0071363 cellular response to growth factor stimulus;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BHR7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BHU9-1", "uniprot_id": [ { "id": "E1BHU9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BHU9", "type": "external" } ], "mass": 138823.0, "length": 1259, "protein_name": "Adenylate cyclase type 5", "gene_name": "ADCY5", "organism": "Bovine", "refseq_name": "adenylate cyclase type 5", "refseq_ac": [ { "id": "NP_001178998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178998", "type": "external" } ], "gene_names_uniprotkb": "ADCY5", "gene_names_refseq": "ADCY5", "protein_names_uniprotkb": "Adenylate cyclase type 5; 4.6.1.1", "protein_names_refseq": "adenylate cyclase type 5", "tax_id": 9913, "disease": "", "pathway": " (bta:505740); (R-BTA-163615); (R-BTA-170660); (R-BTA-170670); (R-BTA-400042); (R-BTA-418597); (R-BTA-5610787)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008179 adenylate cyclase binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0035556 intracellular signal transduction;GO:1904322 cellular response to forskolin", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BHU9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BIH1-1", "uniprot_id": [ { "id": "E1BIH1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BIH1", "type": "external" } ], "mass": 45902.0, "length": 415, "protein_name": "P2X purinoceptor", "gene_name": "P2RX2", "organism": "Bovine", "refseq_name": "P2X purinoceptor 2", "refseq_ac": [ { "id": "NP_001179572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179572", "type": "external" } ], "gene_names_uniprotkb": "P2RX2", "gene_names_refseq": "P2RX2", "protein_names_uniprotkb": "P2X purinoceptor; P2X purinoceptor 2", "protein_names_refseq": "P2X purinoceptor 2; purinergic receptor P2X, ligand-gated ion channel, 2", "tax_id": 9913, "disease": "", "pathway": " (bta:527499); (R-BTA-139853); (R-BTA-418346)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle., [UniProtKB, UniProtKB, UniProtKB]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0001614 purinergic nucleotide receptor activity;GO:0004931 extracellularly ATP-gated monoatomic cation channel activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0016324 apical plasma membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0070588 calcium ion transmembrane transport;GO:0033198 response to ATP", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BIH1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BIN8-1", "uniprot_id": [ { "id": "E1BIN8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BIN8", "type": "external" } ], "mass": 23093.0, "length": 208, "protein_name": "Proheparin-binding EGF-like growth factor", "gene_name": "HBEGF", "organism": "Bovine", "refseq_name": "proheparin-binding EGF-like growth factor precursor", "refseq_ac": [ { "id": "NP_001137562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137562", "type": "external" } ], "gene_names_uniprotkb": "HBEGF", "gene_names_refseq": "DTR; HB-EGF; HBEGF", "protein_names_uniprotkb": "Proheparin-binding EGF-like growth factor", "protein_names_refseq": "diphtheria toxin receptor; heparin-binding epidermal growth factor-like growth factor; proheparin-binding EGF-like growth factor precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:522921); (R-BTA-1227986); (R-BTA-1236394); (R-BTA-1250196); (R-BTA-1250342); (R-BTA-1250347); (R-BTA-1257604); (R-BTA-177929); (R-BTA-179812); (R-BTA-180292); (R-BTA-180336); (R-BTA-182971); (R-BTA-1963640); (R-BTA-1963642); (R-BTA-212718); (R-BTA-2179392); (R-BTA-5673001); (R-BTA-6785631); (R-BTA-6811558); (R-BTA-8847993); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-8857538); (R-BTA-8863795); (R-BTA-9009391)", "pathway_count": 25, "publication_count": 2, "publication_id_list": "15026116;25779761", "class_list": "", "function": "Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor., [UniProtKB, UniProtKB]; Heparin-binding EGF-like growth factor is main component in chromaffin granules responsible for neurotrophic effect on dopaminergic neurones. Protective effects on nigrostriatal dopaminergic neurones. Candidate for treatment of Parkinson's disease., [RefSeq, PubMed]; These results indicate that HB-EGF and its receptors expression changed in bovine endometrium throughout the oestrous cycle; IFN-tau increased their expression in cultured endometrial cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0051549 positive regulation of keratinocyte migration;GO:0048661 positive regulation of smooth muscle cell proliferation;GO:0090303 positive regulation of wound healing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E1BIN8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJ27-1", "uniprot_id": [ { "id": "E1BJ27_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJ27", "type": "external" } ], "mass": 32991.0, "length": 298, "protein_name": "SIX homeobox 2", "gene_name": "SIX2", "organism": "Bovine", "refseq_name": "homeobox protein SIX2 isoform X1", "refseq_ac": [ { "id": "XP_005212711", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212711", "type": "external" } ], "gene_names_uniprotkb": "SIX2", "gene_names_refseq": "SIX2", "protein_names_uniprotkb": "SIX homeobox 2", "protein_names_refseq": "homeobox protein SIX2 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0007501 mesodermal cell fate specification;GO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis;GO:0090189 regulation of branching involved in ureteric bud morphogenesis;GO:0097168 mesenchymal stem cell proliferation;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BJ27-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJI1-1", "uniprot_id": [ { "id": "E1BJI1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJI1", "type": "external" } ], "mass": 50956.0, "length": 456, "protein_name": "Ribosomal RNA-processing protein 8", "gene_name": "RRP8", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RRP8", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribosomal RNA-processing protein 8; 2.1.1.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:540208); (R-BTA-427359)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" } ], "go_molecular_function": "GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005677 chromatin silencing complex;GO:0033553 rDNA heterochromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0097009 energy homeostasis;GO:0042149 cellular response to glucose starvation;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BJI1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9TTK6-1", "uniprot_id": [ { "id": "AOC3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9TTK6", "type": "external" } ], "mass": 84500.0, "length": 763, "protein_name": "Amine oxidase [copper-containing] 3", "gene_name": "AOC3", "organism": "Bovine", "refseq_name": "primary amine oxidase, lung isozyme", "refseq_ac": [ { "id": "NP_851345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851345", "type": "external" } ], "gene_names_uniprotkb": "AOC3", "gene_names_refseq": "AOC3; BOLAO", "protein_names_uniprotkb": "Amine oxidase [copper-containing] 3; 1.4.3.21; Copper amine oxidase; SSAO; Semicarbazide-sensitive amine oxidase; VAP-1; Vascular adhesion protein 1", "protein_names_refseq": "amine oxidase, copper containing 3 (vascular adhesion protein 1); copper amine oxidase; copper containing amine oxidase 3; membrane primary amine oxidase; primary amine oxidase, lung isozyme", "tax_id": 9913, "disease": "", "pathway": " (bta:281002); (R-BTA-211945)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16305752;20079884", "class_list": "", "function": "Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Has a preference for the primary monoamines methylamine and benzylamine. Could also act on 2-phenylethylamine but much less efficiently. At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion., [UniProtKB, UniProtKB]; The lysine-rich protein soluble elastin bound to the enzyme tightly, which may have relevance to the reported roles of copper-containing quinoenzyme semicarbazide-sensitive amine oxidase in maintaining the extracellular matrix and in maturation of elastin, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 5, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A5D7R7;Q58D95", "ec_number_list": [ { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "1.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.4", "type": "external" }, { "id": "1.4.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.21", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005507 copper ion binding;GO:0008131 primary methylamine oxidase activity;GO:0048038 quinone binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0009308 amine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9TTK6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJQ7-1", "uniprot_id": [ { "id": "E1BJQ7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJQ7", "type": "external" } ], "mass": 35965.0, "length": 333, "protein_name": "GIPC PDZ domain containing family member 1", "gene_name": "GIPC1", "organism": "Bovine", "refseq_name": "PDZ domain-containing protein GIPC1", "refseq_ac": [ { "id": "NP_001179947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179947", "type": "external" } ], "gene_names_uniprotkb": "GIPC1", "gene_names_refseq": "GIPC1", "protein_names_uniprotkb": "GIPC PDZ domain containing family member 1", "protein_names_refseq": "PDZ domain-containing protein GIPC1", "tax_id": 9913, "disease": "", "pathway": " (bta:519617)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005938 cell cortex", "go_biological_process": "GO:0046928 regulation of neurotransmitter secretion;GO:0031647 regulation of protein stability;GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway;GO:0008104 intracellular protein localization;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BJQ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJQ9-1", "uniprot_id": [ { "id": "E1BJQ9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJQ9", "type": "external" } ], "mass": 51236.0, "length": 465, "protein_name": "Triacylglycerol lipase", "gene_name": "PNLIP", "organism": "Bovine", "refseq_name": "pancreatic triacylglycerol lipase precursor", "refseq_ac": [ { "id": "NP_001192749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192749", "type": "external" } ], "gene_names_uniprotkb": "PNLIP", "gene_names_refseq": "PNLIP", "protein_names_uniprotkb": "Triacylglycerol lipase; 3.1.1.3; Pancreatic lipase", "protein_names_refseq": "pancreatic triacylglycerol lipase precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:515764); (R-BTA-192456); (R-BTA-975634)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008970 phospholipase A1 activity;GO:0004465 lipoprotein lipase activity;GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0034375 high-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BJQ9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJS9-1", "uniprot_id": [ { "id": "E1BJS9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJS9", "type": "external" } ], "mass": 110155.0, "length": 984, "protein_name": "Ephrin type-A receptor 3", "gene_name": "EPHA3", "organism": "Bovine", "refseq_name": "ephrin type-A receptor 3 precursor", "refseq_ac": [ { "id": "NP_001193042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193042", "type": "external" } ], "gene_names_uniprotkb": "EPHA3", "gene_names_refseq": "EPHA3", "protein_names_uniprotkb": "Ephrin type-A receptor 3; 2.7.10.1; EPH-like kinase 4; Tyrosine-protein kinase TYRO4", "protein_names_refseq": "ephrin type-A receptor 3 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:537951); (R-BTA-2682334); (R-BTA-3928663); (R-BTA-3928665)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Also activated by EFNA1, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005004 GPI-linked ephrin receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0045806 negative regulation of endocytosis;GO:0010976 positive regulation of neuron projection development;GO:0032956 regulation of actin cytoskeleton organization;GO:0048013 ephrin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BJS9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BK52-1", "uniprot_id": [ { "id": "STK10_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BK52", "type": "external" } ], "mass": 111615.0, "length": 966, "protein_name": "Serine/threonine-protein kinase 10", "gene_name": "STK10", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "STK10", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase 10; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0046777 protein autophosphorylation;GO:2000401 regulation of lymphocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BK52-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKI3-1", "uniprot_id": [ { "id": "E1BKI3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKI3", "type": "external" } ], "mass": 179507.0, "length": 1613, "protein_name": "Nitric oxide synthase 1", "gene_name": "NOS1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NOS1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nitric oxide synthase 1; 1.14.13.39; Constitutive NOS; NC-NOS; NOS type I; Neuronal NOS; Nitric oxide synthase, brain; Peptidyl-cysteine S-nitrosylase NOS1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1222556); (R-BTA-392154); (R-BTA-5578775)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0010181 FMN binding;GO:0035605 peptidyl-cysteine S-nitrosylase activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005739 mitochondrion;GO:0005856 cytoskeleton;GO:0043197 dendritic spine;GO:0005901 caveola", "go_biological_process": "GO:0001666 response to hypoxia;GO:0042311 vasodilation;GO:0045893 positive regulation of DNA-templated transcription;GO:0071363 cellular response to growth factor stimulus;GO:0006809 nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BKI3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKK0-1", "uniprot_id": [ { "id": "E2F8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKK0", "type": "external" } ], "mass": 94043.0, "length": 866, "protein_name": "Transcription factor E2F8", "gene_name": "E2F8", "organism": "Bovine", "refseq_name": "transcription factor E2F8", "refseq_ac": [ { "id": "NP_001178163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178163", "type": "external" } ], "gene_names_uniprotkb": "E2F8", "gene_names_refseq": "E2F-8; E2F8", "protein_names_uniprotkb": "Transcription factor E2F8; E2F-8", "protein_names_refseq": "transcription factor E2F8", "tax_id": 9913, "disease": "", "pathway": " (bta:786629); (R-BTA-6804116)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19393038;31493442", "class_list": "", "function": "Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene (By similarity)., [UniProtKB]; IGF1 amplified the stimulatory effect of FGF9 on E2F8 mRNA abundance by 2.7-fold, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001217 DNA-binding transcription repressor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0032877 positive regulation of DNA endoreduplication;GO:0033301 cell cycle comprising mitosis without cytokinesis;GO:0060718 chorionic trophoblast cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E1BKK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKN2-1", "uniprot_id": [ { "id": "E1BKN2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKN2", "type": "external" } ], "mass": 149388.0, "length": 1358, "protein_name": "Tenascin-R", "gene_name": "TNR", "organism": "Bovine", "refseq_name": "tenascin-R precursor", "refseq_ac": [ { "id": "NP_001192857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192857", "type": "external" } ], "gene_names_uniprotkb": "TNR", "gene_names_refseq": "TNR", "protein_names_uniprotkb": "Tenascin-R; Janusin; Restrictin", "protein_names_refseq": "tenascin R (restrictin, janusin); tenascin-R precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:526409); (R-BTA-3000178)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0045121 membrane raft", "go_biological_process": "GO:0007155 cell adhesion;GO:0007399 nervous system development;GO:0030155 regulation of cell adhesion;GO:0030334 regulation of cell migration;GO:0045595 regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BKN2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKU0-1", "uniprot_id": [ { "id": "E1BKU0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKU0", "type": "external" } ], "mass": 43713.0, "length": 401, "protein_name": "Adenosine receptor A2", "gene_name": "ADORA2A", "organism": "Bovine", "refseq_name": "adenosine receptor A2a", "refseq_ac": [ { "id": "XP_024833621", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833621", "type": "external" } ], "gene_names_uniprotkb": "ADORA2A", "gene_names_refseq": "ADORA2A", "protein_names_uniprotkb": "Adenosine receptor A2", "protein_names_refseq": "adenosine receptor A2a", "tax_id": 9913, "disease": "", "pathway": " (bta:617828); (R-BTA-417973); (R-BTA-418555); (R-BTA-5683826)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0001609 G protein-coupled adenosine receptor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0014074 response to purine-containing compound;GO:0001963 synaptic transmission, dopaminergic;GO:0001973 G protein-coupled adenosine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BKU0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BLT8-1", "uniprot_id": [ { "id": "ZDHC5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BLT8", "type": "external" } ], "mass": 76976.0, "length": 714, "protein_name": "Palmitoyltransferase ZDHHC5", "gene_name": "ZDHHC5", "organism": "Bovine", "refseq_name": "palmitoyltransferase ZDHHC5", "refseq_ac": [ { "id": "NP_001179692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179692", "type": "external" } ], "gene_names_uniprotkb": "ZDHHC5", "gene_names_refseq": "DHHC-5; ZDHHC5", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC5; 2.3.1.225; DHHC-5; Zinc finger DHHC domain-containing protein 5", "protein_names_refseq": "palmitoyltransferase ZDHHC5; zinc finger DHHC domain-containing protein 5; zinc finger DHHC-type containing 5", "tax_id": 9913, "disease": "", "pathway": " (bta:533250)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions. Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins. Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2. Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2. Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes. Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane. Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (By similarity). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD. Palmitoylates NLRP3 to promote inflammasome assembly and activation. Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (By similarity). Palmitoylates IFT81 and may contribute to maintaining its protein stability during spermatogenesis thereby supporting proper sperm tail assembly (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0098794 postsynapse", "go_biological_process": "GO:0006869 lipid transport;GO:0007283 spermatogenesis;GO:0045087 innate immune response;GO:0072659 protein localization to plasma membrane;GO:1903078 positive regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BLT8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BLZ8-1", "uniprot_id": [ { "id": "E1BLZ8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BLZ8", "type": "external" } ], "mass": 40895.0, "length": 390, "protein_name": "Eukaryotic translation initiation factor 3 subunit F", "gene_name": "EIF3F", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EIF3F; EIF3S5", "gene_names_refseq": "", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit F; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47; eIF3f", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:513793); (R-BTA-156827); (R-BTA-72649); (R-BTA-72689); (R-BTA-72695); (R-BTA-72702)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, HAMAP]; Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003743 translation initiation factor activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0031369 translation initiation factor binding;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0045202 synapse;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m", "go_biological_process": "GO:0075522 IRES-dependent viral translational initiation;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BLZ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BM28-1", "uniprot_id": [ { "id": "E1BM28_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BM28", "type": "external" } ], "mass": 23176.0, "length": 215, "protein_name": "2'-deoxynucleoside 5'-phosphate N-hydrolase 1", "gene_name": "DNPH1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DNPH1; RCL", "gene_names_refseq": "", "protein_names_uniprotkb": "2'-deoxynucleoside 5'-phosphate N-hydrolase 1; 3.2.2.-; c-Myc-responsive protein RCL", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-74259)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases., [UniProtKB, HAMAP]; Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0070694 5-hydroxymethyl-dUMP N-hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006195 purine nucleotide catabolic process;GO:0009116 nucleoside metabolic process;GO:0009159 deoxyribonucleoside monophosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BM28-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BME7-1", "uniprot_id": [ { "id": "E1BME7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BME7", "type": "external" } ], "mass": 31681.0, "length": 315, "protein_name": "Paired like homeobox 2B", "gene_name": "PHOX2B", "organism": "Bovine", "refseq_name": "paired mesoderm homeobox protein 2B", "refseq_ac": [ { "id": "XP_002688259", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688259", "type": "external" } ], "gene_names_uniprotkb": "PHOX2B", "gene_names_refseq": "PHOX2B", "protein_names_uniprotkb": "Paired like homeobox 2B", "protein_names_refseq": "paired mesoderm homeobox protein 2B", "tax_id": 9913, "disease": "", "pathway": " (bta:783703)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0003360 brainstem development;GO:0048484 enteric nervous system development;GO:0021723 medullary reticular formation development;GO:0048486 parasympathetic nervous system development;GO:0061452 retrotrapezoid nucleus neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BME7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BMN8-1", "uniprot_id": [ { "id": "NLK_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BMN8", "type": "external" } ], "mass": 59339.0, "length": 534, "protein_name": "Serine/threonine-protein kinase NLK", "gene_name": "NLK", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NLK", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase NLK; 2.7.11.24; Nemo-like kinase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner. Acts as an inhibitor of the mTORC1 complex in response to osmotic stress by mediating phosphorylation of RPTOR, thereby preventing recruitment of the mTORC1 complex to lysosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0035556 intracellular signal transduction;GO:0050821 protein stabilization;GO:0016055 Wnt signaling pathway;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BMN8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BMP7-1", "uniprot_id": [ { "id": "DNA2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BMP7", "type": "external" } ], "mass": 120485.0, "length": 1061, "protein_name": "DNA replication ATP-dependent helicase/nuclease DNA2", "gene_name": "DNA2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DNA2", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA replication ATP-dependent helicase/nuclease DNA2; DNA 5'-3' helicase DNA2; DNA replication ATP-dependent helicase-like homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-174437); (R-BTA-5685938); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5693568); (R-BTA-5693579); (R-BTA-5693607); (R-BTA-5693616); (R-BTA-6804756); (R-BTA-69166); (R-BTA-69473)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is absent to weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006284 base-excision repair;GO:0006260 DNA replication;GO:0000729 DNA double-strand break processing;GO:0033567 DNA replication, Okazaki fragment processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BMP7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BMU2-1", "uniprot_id": [ { "id": "E1BMU2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BMU2", "type": "external" } ], "mass": 21460.0, "length": 190, "protein_name": "Cytoglobin", "gene_name": "CYGB", "organism": "Bovine", "refseq_name": "cytoglobin", "refseq_ac": [ { "id": "NP_001193649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193649", "type": "external" } ], "gene_names_uniprotkb": "CYGB", "gene_names_refseq": "CYGB; GLNF", "protein_names_uniprotkb": "Cytoglobin; 1.15.1.1; Nitrite reductase CYGB; Pseudoperoxidase CYGB; Superoxide dismutase CYGB", "protein_names_refseq": "cytoglobin; globin F", "tax_id": 9913, "disease": "", "pathway": " (bta:510299); (R-BTA-203615); (R-BTA-8981607)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability. Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption. By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone. Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide. Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress. Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A1K0FUK0", "ec_number_list": [ { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0004784 superoxide dismutase activity;GO:0019825 oxygen binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:0046210 nitric oxide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BMU2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNF3-1", "uniprot_id": [ { "id": "E1BNF3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNF3", "type": "external" } ], "mass": 45330.0, "length": 421, "protein_name": "Forkhead box J1", "gene_name": "FOXJ1", "organism": "Bovine", "refseq_name": "forkhead box protein J1", "refseq_ac": [ { "id": "NP_001179005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179005", "type": "external" } ], "gene_names_uniprotkb": "FOXJ1", "gene_names_refseq": "FOXJ1", "protein_names_uniprotkb": "Forkhead box J1", "protein_names_refseq": "forkhead box protein J1", "tax_id": 9913, "disease": "", "pathway": " (bta:505891)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0002508 central tolerance induction;GO:0002635 negative regulation of germinal center formation;GO:0002897 positive regulation of central B cell tolerance induction;GO:0072016 glomerular parietal epithelial cell development;GO:1901248 positive regulation of lung ciliated cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BNF3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNG3-1", "uniprot_id": [ { "id": "ASCC3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNG3", "type": "external" } ], "mass": 250765.0, "length": 2201, "protein_name": "Activating signal cointegrator 1 complex subunit 3", "gene_name": "ASCC3; ascc3", "organism": "Bovine", "refseq_name": "activating signal cointegrator 1 complex subunit 3", "refseq_ac": [ { "id": "NP_001193047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193047", "type": "external" } ], "gene_names_uniprotkb": "ASCC3; ascc3", "gene_names_refseq": "ASCC3", "protein_names_uniprotkb": "Activating signal cointegrator 1 complex subunit 3; 5.6.2.4", "protein_names_refseq": "activating signal cointegrator 1 complex subunit 3", "tax_id": 9913, "disease": "", "pathway": " (bta:538416); (R-BTA-9954716)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "ATPase involved both in DNA repair and rescue of stalled ribosomes. 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0180022 RQC-trigger complex;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006307 DNA alkylation repair;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BNG3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNQ3-1", "uniprot_id": [ { "id": "E1BNQ3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNQ3", "type": "external" } ], "mass": 26162.0, "length": 231, "protein_name": "Ras-related protein Rap-2", "gene_name": "RAP2A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RAP2A", "gene_names_refseq": "", "protein_names_uniprotkb": "Ras-related protein Rap-2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0055038 recycling endosome membrane;GO:0031258 lamellipodium membrane", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0030335 positive regulation of cell migration;GO:0048814 regulation of dendrite morphogenesis;GO:0030336 negative regulation of cell migration;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BNQ3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNS8-1", "uniprot_id": [ { "id": "E1BNS8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNS8", "type": "external" } ], "mass": 84282.0, "length": 778, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "SIK1", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase SIK1", "refseq_ac": [ { "id": "XP_024852416", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852416", "type": "external" } ], "gene_names_uniprotkb": "SIK1", "gene_names_refseq": "SIK1", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase SIK1", "tax_id": 9913, "disease": "", "pathway": " (bta:100337254)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010830 regulation of myotube differentiation;GO:0035556 intracellular signal transduction;GO:0007346 regulation of mitotic cell cycle;GO:0055007 cardiac muscle cell differentiation;GO:0045721 negative regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BNS8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNU6-1", "uniprot_id": [ { "id": "E1BNU6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNU6", "type": "external" } ], "mass": 61589.0, "length": 570, "protein_name": "Molecular chaperone MKKS", "gene_name": "MKKS", "organism": "Bovine", "refseq_name": "molecular chaperone MKKS", "refseq_ac": [ { "id": "NP_001193100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193100", "type": "external" } ], "gene_names_uniprotkb": "MKKS", "gene_names_refseq": "MKKS", "protein_names_uniprotkb": "Molecular chaperone MKKS; McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin", "protein_names_refseq": "McKusick-Kaufman syndrome; molecular chaperone MKKS", "tax_id": 9913, "disease": "", "pathway": " (bta:614288); (R-BTA-5620922)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, 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"https://www.uniprot.org/uniprot/E1BP01", "type": "external" } ], "mass": 181555.0, "length": 1585, "protein_name": "Myosin-IIIa", "gene_name": "MYO3A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MYO3A", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin-IIIa; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:535824)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, 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"https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0043531 ADP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment;GO:0031941 filamentous actin;GO:0032433 filopodium tip;GO:0032426 stereocilium tip", "go_biological_process": "GO:0030832 regulation of actin filament length;GO:0007601 visual perception;GO:0007605 sensory perception of sound;GO:0051491 positive regulation of filopodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BP01-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BP99-1", "uniprot_id": [ { "id": "E1BP99_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BP99", "type": "external" } ], "mass": 28428.0, "length": 236, "protein_name": "C->U-editing enzyme APOBEC-1", "gene_name": "APOBEC1", "organism": "Bovine", "refseq_name": "C->U-editing enzyme APOBEC-1", "refseq_ac": [ { "id": "XP_002687863", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687863", "type": "external" } ], "gene_names_uniprotkb": "APOBEC1", "gene_names_refseq": "APOBEC1", "protein_names_uniprotkb": "C->U-editing enzyme APOBEC-1; 3.5.4.36; mRNA(cytosine(6666)) deaminase 1", "protein_names_refseq": "C->U-editing enzyme APOBEC-1", "tax_id": 9913, "disease": "", "pathway": " (bta:516043); (R-BTA-72200); (R-BTA-75094)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs. Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.36", "type": "external" }, { "id": "3.5.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.38", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0006397 mRNA processing;GO:0016554 cytidine to uridine editing;GO:0016556 mRNA modification;GO:1903311 regulation of mRNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BP99-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BPN0-1", "uniprot_id": [ { "id": "NOL9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BPN0", "type": "external" } ], "mass": 78133.0, "length": 694, "protein_name": "Polynucleotide 5'-hydroxyl-kinase NOL9", "gene_name": "NOL9", "organism": "Bovine", "refseq_name": "polynucleotide 5'-hydroxyl-kinase NOL9", "refseq_ac": [ { "id": "NP_001193528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193528", "type": "external" } ], "gene_names_uniprotkb": "NOL9", "gene_names_refseq": "NOL9", "protein_names_uniprotkb": "Polynucleotide 5'-hydroxyl-kinase NOL9; 2.7.1.78; Nucleolar protein 9", "protein_names_refseq": "polynucleotide 5'-hydroxyl-kinase NOL9", "tax_id": 9913, "disease": "", "pathway": " (bta:523474); (R-BTA-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (By similarity). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0051736 ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0051731 polynucleotide 5'-hydroxyl-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0000460 maturation of 5.8S rRNA;GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BPN0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BQ28-1", "uniprot_id": [ { "id": "E1BQ28_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BQ28", "type": "external" } ], "mass": 49819.0, "length": 461, "protein_name": "Solute carrier family 39 member 8", "gene_name": "SLC39A8", "organism": "Bovine", "refseq_name": "metal cation symporter ZIP8 precursor", "refseq_ac": [ { "id": "NP_001192559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192559", "type": "external" } ], "gene_names_uniprotkb": "SLC39A8", "gene_names_refseq": "SLC39A8", "protein_names_uniprotkb": "Solute carrier family 39 member 8", "protein_names_refseq": "metal cation symporter ZIP8 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:508193); (R-BTA-442380)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0140412 zinc:bicarbonate symporter activity;GO:0140410 monoatomic cation:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0006882 intracellular zinc ion homeostasis;GO:0030003 intracellular monoatomic cation homeostasis;GO:0071578 zinc ion import across plasma membrane;GO:0030026 intracellular manganese ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BQ28-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MBN0-1", "uniprot_id": [ { "id": "F1MBN0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MBN0", "type": "external" } ], "mass": 76086.0, "length": 663, "protein_name": "Cyclic nucleotide-gated channel alpha-2", "gene_name": "CNGA2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CNGA2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel alpha-2; Olfactory cyclic nucleotide-gated channel subunit 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5620916)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0030552 cAMP binding;GO:0030553 cGMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0017071 intracellular cyclic nucleotide activated cation channel complex;GO:0098804 non-motile cilium membrane", "go_biological_process": "GO:0098655 monoatomic cation transmembrane transport;GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MBN0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MBP6-1", "uniprot_id": [ { "id": "KLHL3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MBP6", "type": "external" } ], "mass": 64978.0, "length": 587, "protein_name": "Kelch-like protein 3", "gene_name": "HNRNPA0; KLHL3", "organism": "Bovine", "refseq_name": "kelch-like protein 3 isoform X2", "refseq_ac": [ { "id": "XP_002689253", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689253", "type": "external" } ], "gene_names_uniprotkb": "HNRNPA0; KLHL3; HNRNPA0", "gene_names_refseq": "KLHL3", "protein_names_uniprotkb": "Kelch-like protein 3", "protein_names_refseq": "kelch-like protein 3 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:533364); (bta:540311); (R-BTA-8951664); (R-BTA-983168)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination and degradation of WNK1 and WNK4, two activators of Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney, thereby regulating NaCl reabsorption. The BCR(KLHL3) complex also mediates ubiquitination and degradation of WNK3 (By similarity). The BCR(KLHL3) complex also mediates ubiquitination of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney, leading to its degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0003729 mRNA binding;GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0005634 nucleus", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0050801 monoatomic ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MBP6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MC37-1", "uniprot_id": [ { "id": "F1MC37_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MC37", "type": "external" } ], "mass": 58773.0, "length": 517, "protein_name": "L-dopachrome tautomerase", "gene_name": "DCT", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DCT", "gene_names_refseq": "", "protein_names_uniprotkb": "L-dopachrome tautomerase; 5.3.3.12; L-dopachrome Delta-isomerase; Tyrosinase-related protein 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5662702)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in melanin biosynthesis. Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0004167 dopachrome isomerase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0042470 melanosome;GO:0033162 melanosome membrane", "go_biological_process": "GO:0002052 positive regulation of neuroblast proliferation;GO:0048066 developmental pigmentation;GO:0021847 ventricular zone neuroblast division;GO:0006583 melanin biosynthetic process from tyrosine;GO:0009637 response to blue light", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MC37-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MC61-1", "uniprot_id": [ { "id": "F1MC61_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MC61", "type": "external" } ], "mass": 94553.0, "length": 864, "protein_name": "Mitogen-activated protein kinase kinase kinase", "gene_name": "MAP3K11", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MAP3K11", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase; 2.7.11.25", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5673000); (R-BTA-9013408); (R-BTA-9013424)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0031435 mitogen-activated protein kinase kinase kinase binding;GO:0004706 JUN kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0034451 centriolar satellite", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0007254 JNK cascade;GO:0044843 cell cycle G1/S phase transition;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MC61-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MC93-1", "uniprot_id": [ { "id": "F1MC93_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MC93", "type": "external" } ], "mass": 55827.0, "length": 496, "protein_name": "Neuronal acetylcholine receptor subunit beta-4", "gene_name": "CHRNB4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CHRNB4", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:282181); (R-BTA-629587); (R-BTA-629594); (R-BTA-629597); (R-BTA-6798695)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0043005 neuron projection;GO:0098981 cholinergic synapse", "go_biological_process": "GO:0060084 synaptic transmission involved in micturition;GO:0095500 acetylcholine receptor signaling pathway;GO:0034220 monoatomic ion transmembrane transport;GO:0051899 membrane depolarization;GO:0051971 positive regulation of transmission of nerve impulse", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MC93-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MCA7-1", "uniprot_id": [ { "id": "LRRC7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MCA7", "type": "external" } ], "mass": 172407.0, "length": 1536, "protein_name": "Leucine-rich repeat-containing protein 7", "gene_name": "LRRC7", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LRRC7", "gene_names_refseq": "", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 7; Densin-180; Densin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Adapter protein that is required for correct postsynapse architecture and regulates postsynaptic plasticity through interactions with different partners. Through its interaction with CACNA1C, it enhances trafficking of voltage-dependent L-type calcium channels to the dendritic cell membrane and increases channel postsynaptic clustering, thereby facilitating excitatory calcium signaling (By similarity). It also serves as a scaffold that brings CAMK2A and PPP1CA into close proximity, probably facilitating rapid dephosphorylation of CAMK2A by PPP1CA and influencing CAMK2A-mediated regulation of postsynaptic plasticity (By similarity). Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term synaptic depression (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005912 adherens junction;GO:0014069 postsynaptic density;GO:0016323 basolateral plasma membrane;GO:0043194 axon initial segment", "go_biological_process": "GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0010976 positive regulation of neuron projection development;GO:0098609 cell-cell adhesion;GO:0043113 receptor clustering;GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MCA7-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MCX4-1", "uniprot_id": [ { "id": "F1MCX4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MCX4", "type": "external" } ], "mass": 132877.0, "length": 1187, "protein_name": "Tyrosine-protein kinase", "gene_name": "TYK2", "organism": "Bovine", "refseq_name": "non-receptor tyrosine-protein kinase TYK2 isoform X1", "refseq_ac": [ { "id": "XP_005208794", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208794", "type": "external" } ], "gene_names_uniprotkb": "TYK2", "gene_names_refseq": "TYK2", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "non-receptor tyrosine-protein kinase TYK2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1059683); (R-BTA-110056); (R-BTA-449836); (R-BTA-6783783); (R-BTA-6785807); (R-BTA-6788467); (R-BTA-8854691); (R-BTA-8984722); (R-BTA-9020591); (R-BTA-9020933); (R-BTA-9020956); (R-BTA-909733); (R-BTA-912694); (R-BTA-9674555); (R-BTA-9705462); (R-BTA-9958825)", "pathway_count": 16, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0005131 growth hormone receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0008283 cell population proliferation;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:0060333 type II interferon-mediated signaling pathway;GO:0060337 type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MCX4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MCX7-1", "uniprot_id": [ { "id": "F1MCX7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MCX7", "type": "external" } ], "mass": 74519.0, "length": 706, "protein_name": "Synapsin-1", "gene_name": "SYN1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SYN1", "gene_names_refseq": "", "protein_names_uniprotkb": "Synapsin-1; Synapsin I", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-181429); (R-BTA-212676)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal. Also involved in the regulation of axon outgrowth and synaptogenesis. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0050808 synapse organization;GO:0007269 neurotransmitter secretion;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0098693 regulation of synaptic vesicle cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MCX7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MCY2-1", "uniprot_id": [ { "id": "PHAR4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MCY2", "type": "external" } ], "mass": 78821.0, "length": 712, "protein_name": "Phosphatase and actin regulator 4", "gene_name": "PHACTR4", "organism": "Bovine", "refseq_name": "phosphatase and actin regulator 4", "refseq_ac": [ { "id": "NP_001095477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095477", "type": "external" } ], "gene_names_uniprotkb": "PHACTR4", "gene_names_refseq": "PHACTR4", "protein_names_uniprotkb": "Phosphatase and actin regulator 4", "protein_names_refseq": "phosphatase and actin regulator 4", "tax_id": 9913, "disease": "", "pathway": " (bta:514644)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6QP20", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008157 protein phosphatase 1 binding;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030027 lamellipodium", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0061386 closure of optic fissure;GO:0043085 positive regulation of catalytic activity;GO:0030036 actin cytoskeleton organization;GO:0007266 Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MCY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MD21-1", "uniprot_id": [ { "id": "F1MD21_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MD21", "type": "external" } ], "mass": 40814.0, "length": 372, "protein_name": "Homeobox protein Hox-A2", "gene_name": "HOXA2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HOXA2", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-A2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0060037 pharyngeal system development;GO:0048706 embryonic skeletal system development;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MD21-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MD60-1", "uniprot_id": [ { "id": "F1MD60_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MD60", "type": "external" } ], "mass": 69039.0, "length": 622, "protein_name": "Solute carrier family 24 member 4", "gene_name": "SLC24A4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC24A4", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 24 member 4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-425561)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0048306 calcium-dependent protein binding;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031982 vesicle;GO:0120199 cone photoreceptor outer segment", "go_biological_process": "GO:0050849 negative regulation of calcium-mediated signaling;GO:0006874 intracellular calcium ion homeostasis;GO:0007608 sensory perception of smell;GO:0070588 calcium ion transmembrane transport;GO:0071486 cellular response to high light intensity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MD60-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MDG4-1", "uniprot_id": [ { "id": "F1MDG4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MDG4", "type": "external" } ], "mass": 43410.0, "length": 385, "protein_name": "Fucosyltransferase", "gene_name": "FUT4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FUT4", "gene_names_refseq": "", "protein_names_uniprotkb": "Fucosyltransferase; 2.4.1.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9037629)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.65", "type": "external" }, { "id": "2.4.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.152", "type": "external" } ], "go_molecular_function": "GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0032580 Golgi cisterna membrane;GO:0071944 cell periphery;GO:0005802 trans-Golgi network", "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006954 inflammatory response;GO:0009101 glycoprotein biosynthetic process;GO:0009311 oligosaccharide metabolic process;GO:0097022 lymphocyte migration into lymph node", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MDG4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1ME70-1", "uniprot_id": [ { "id": "F1ME70_BOVIN", "url": "https://www.uniprot.org/uniprot/F1ME70", "type": "external" } ], "mass": 56093.0, "length": 536, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 10", "gene_name": "SLC2A10", "organism": "Bovine", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 10", "refseq_ac": [ { "id": "NP_001179368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179368", "type": "external" } ], "gene_names_uniprotkb": "SLC2A10", "gene_names_refseq": "SLC2A10", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 10; Glucose transporter type 10", "protein_names_refseq": "solute carrier family 2, facilitated glucose transporter member 10", "tax_id": 9913, "disease": "", "pathway": " (bta:516135); (R-BTA-189200)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Facilitative glucose transporter required for the development of the cardiovascular system., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0072359 circulatory system development;GO:1904659 D-glucose transmembrane transport;GO:0098708 D-glucose import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1ME70-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEG3-1", "uniprot_id": [ { "id": "F1MEG3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEG3", "type": "external" } ], "mass": 337580.0, "length": 3089, "protein_name": "Basement membrane-specific heparan sulfate proteoglycan core protein", "gene_name": "LAMA1", "organism": "Bovine", "refseq_name": "laminin subunit alpha-1 isoform X1", "refseq_ac": [ { "id": "XP_024840372", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840372", "type": "external" } ], "gene_names_uniprotkb": "LAMA1", "gene_names_refseq": "LAMA1", "protein_names_uniprotkb": "Basement membrane-specific heparan sulfate proteoglycan core protein; Laminin A chain; Laminin M chain; Laminin subunit alpha-2; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; Merosin heavy chain; Perlecan", "protein_names_refseq": "laminin subunit alpha-1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:506387)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6., [UniProtKB, UniProtKB]; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB, UniProtKB]; Has anti-angiogenic properties that require binding of calcium ions for full activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0046872 metal ion binding;GO:0048018 receptor ligand activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0005604 basement membrane", "go_biological_process": "GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0030155 regulation of cell adhesion;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEG3-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEM5-1", "uniprot_id": [ { "id": "F1MEM5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEM5", "type": "external" } ], "mass": 109820.0, "length": 956, "protein_name": "Aminopeptidase", "gene_name": "ENPEP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENPEP", "gene_names_refseq": "", "protein_names_uniprotkb": "Aminopeptidase; 3.4.11.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2022377)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity;GO:0004230 glutamyl aminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0002003 angiotensin maturation;GO:0043171 peptide catabolic process;GO:0032835 glomerulus development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEM5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MET0-1", "uniprot_id": [ { "id": "F1MET0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MET0", "type": "external" } ], "mass": 85896.0, "length": 751, "protein_name": "procollagen-lysine 5-dioxygenase", "gene_name": "PLOD3", "organism": "Bovine", "refseq_name": "multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor", "refseq_ac": [ { "id": "NP_001180184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180184", "type": "external" } ], "gene_names_uniprotkb": "PLOD3", "gene_names_refseq": "PLOD3", "protein_names_uniprotkb": "procollagen-lysine 5-dioxygenase; 1.14.11.4", "protein_names_refseq": "multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:514996); (R-BTA-1650814)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.4", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0008475 procollagen-lysine 5-dioxygenase activity;GO:0050211 procollagen galactosyltransferase activity;GO:0033823 procollagen glucosyltransferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0032964 collagen biosynthetic process;GO:0046947 hydroxylysine biosynthetic process;GO:0180062 protein O-linked glycosylation via galactose", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MET0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MF74-1", "uniprot_id": [ { "id": "MICA2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MF74", "type": "external" } ], "mass": 207144.0, "length": 1865, "protein_name": "[F-actin]-monooxygenase MICAL2", "gene_name": "MICAL2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MICAL2", "gene_names_refseq": "", "protein_names_uniprotkb": "[F-actin]-monooxygenase MICAL2; 1.14.13.225; MICAL-2; Molecule interacting with CasL protein 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:534041)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A3Q1LSU4", "ec_number_list": [ { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" } ], "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005654 nucleoplasm", "go_biological_process": "GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MF74-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MG60-1", "uniprot_id": [ { "id": "F1MG60_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MG60", "type": "external" } ], "mass": 118830.0, "length": 1043, "protein_name": "V(D)J recombination-activating protein 1", "gene_name": "RAG1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RAG1", "gene_names_refseq": "", "protein_names_uniprotkb": "V(D)J recombination-activating protein 1; 2.3.2.27; 3.1.-.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity;GO:0061630 ubiquitin protein ligase activity;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0097519 DNA recombinase complex;GO:1905347 endodeoxyribonuclease complex", "go_biological_process": "GO:0002250 adaptive immune response;GO:0006325 chromatin organization;GO:0051865 protein autoubiquitination;GO:0033077 T cell differentiation in thymus;GO:0002331 pre-B cell allelic exclusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MG60-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGH8-1", "uniprot_id": [ { "id": "F1MGH8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGH8", "type": "external" } ], "mass": 59974.0, "length": 547, "protein_name": "Solute carrier family 22 member 7", "gene_name": "SLC22A7", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC22A7", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 22 member 7; Organic anion transporter 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-561048); (R-BTA-9749641)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0015132 prostaglandin transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGH8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGJ4-1", "uniprot_id": [ { "id": "F1MGJ4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGJ4", "type": "external" } ], "mass": 94316.0, "length": 847, "protein_name": "Signal transducer and activator of transcription", "gene_name": "STAT6", "organism": "Bovine", "refseq_name": "signal transducer and activator of transcription 6", "refseq_ac": [ { "id": "NP_001192430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192430", "type": "external" } ], "gene_names_uniprotkb": "STAT6", "gene_names_refseq": "STAT6", "protein_names_uniprotkb": "Signal transducer and activator of transcription", "protein_names_refseq": "signal transducer and activator of transcription 6, interleukin-4 induced; signal transducer and activator of transcription 6", "tax_id": 9913, "disease": "", "pathway": " (bta:353105); (R-BTA-186763); (R-BTA-3249367); (R-BTA-6785807)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "19519791", "class_list": "", "function": "Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling., [UniProtKB, UniProtKB]; Results provide evidence that polymorphisms in STAT6 are associated with carcass and growth efficiency traits, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0035771 interleukin-4-mediated signaling pathway;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006952 defense response;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MGJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGK2-1", "uniprot_id": [ { "id": "F1MGK2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGK2", "type": "external" } ], "mass": 239350.0, "length": 2166, "protein_name": "Methylcytosine dioxygenase TET", "gene_name": "TET1", "organism": "Bovine", "refseq_name": "methylcytosine dioxygenase TET1 isoform X1", "refseq_ac": [ { "id": "XP_024842706", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842706", "type": "external" } ], "gene_names_uniprotkb": "TET1", "gene_names_refseq": "TET1", "protein_names_uniprotkb": "Methylcytosine dioxygenase TET; 1.14.11.80", "protein_names_refseq": "methylcytosine dioxygenase TET1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:513640)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.80", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008327 methyl-CpG binding;GO:0070579 DNA 5-methylcytosine dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0005694 chromosome", "go_biological_process": "GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034614 cellular response to reactive oxygen species;GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGK2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGM3-1", "uniprot_id": [ { "id": "F1MGM3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGM3", "type": "external" } ], "mass": 44652.0, "length": 403, "protein_name": "5-hydroxytryptamine receptor 1B", "gene_name": "HTR1B", "organism": "Bovine", "refseq_name": "5-hydroxytryptamine receptor 1B", "refseq_ac": [ { "id": "XP_024852688", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852688", "type": "external" } ], "gene_names_uniprotkb": "HTR1B", "gene_names_refseq": "HTR1B", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT1B; Serotonin receptor 1B", "protein_names_refseq": "5-hydroxytryptamine receptor 1B", "tax_id": 9913, "disease": "", "pathway": " (bta:317707); (R-BTA-390666); (R-BTA-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0001586 Gi/o-coupled serotonin receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0042734 presynaptic membrane;GO:0099154 serotonergic synapse", "go_biological_process": "GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0071466 cellular response to xenobiotic stimulus;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway;GO:0014063 negative regulation of serotonin secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGM3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHC7-1", "uniprot_id": [ { "id": "F1MHC7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHC7", "type": "external" } ], "mass": 40356.0, "length": 359, "protein_name": "Gap junction protein", "gene_name": "GJA5", "organism": "Bovine", "refseq_name": "gap junction alpha-5 protein isoform X1", "refseq_ac": [ { "id": "XP_005204050", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204050", "type": "external" } ], "gene_names_uniprotkb": "GJA5", "gene_names_refseq": "CXNI; GJA5", "protein_names_uniprotkb": "Gap junction protein", "protein_names_refseq": "gap junction alpha-5 protein isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-190861)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB, UniProtKB]; Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0055077 gap junction hemi-channel activity;GO:0086076 gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling;GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling;GO:0086078 gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling", "go_cellular_component": "GO:0014704 intercalated disc;GO:0005922 connexin complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007267 cell-cell signaling;GO:0007507 heart development;GO:0003281 ventricular septum development;GO:0003283 atrial septum development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHC7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHQ4-1", "uniprot_id": [ { "id": "F1MHQ4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHQ4", "type": "external" } ], "mass": 14646.0, "length": 132, "protein_name": "Fatty acid binding protein 4, adipocyte", "gene_name": "FABP4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FABP4", "gene_names_refseq": "", "protein_names_uniprotkb": "Fatty acid binding protein 4, adipocyte", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-163560)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, 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Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2VDM2", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005509 calcium ion binding;GO:0120548 phosphatidylinositol phospholipase C activity;GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process;GO:0046488 phosphatidylinositol metabolic process;GO:0141212 phospholipase C/protein kinase C signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P10895-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N2E9-1", "uniprot_id": [ { "id": "G3N2E9_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N2E9", "type": "external" } ], "mass": 159828.0, "length": 1453, "protein_name": "[histone H3]-trimethyl-L-lysine(27) demethylase", "gene_name": "KDM6A", "organism": "Bovine", "refseq_name": "lysine-specific demethylase 6A", "refseq_ac": [ { "id": "NP_001193504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193504", "type": "external" } ], "gene_names_uniprotkb": "KDM6A", "gene_names_refseq": "KDM6A; UTX", "protein_names_uniprotkb": "[histone H3]-trimethyl-L-lysine(27) demethylase; 1.14.11.68", "protein_names_refseq": "lysine-specific demethylase 6A; ubiqiutous TPR motif protein; ubiquitously transcribed tetratricopeptide repeat gene, X chromosome; ubiquitously transcribed tetratricopeptide repeat, X chromosome", "tax_id": 9913, "disease": "", "pathway": " (bta:280952); (R-BTA-3214842); (R-BTA-9772755); (R-BTA-9818564)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "30673507", "class_list": "", "function": "H3K27me3 plays a role in bovine somatic cell nuclear transfer (SCNT) reprogramming from the 2- to 8-cell stage. Its removal by ectopically expressed KDM6A greatly improves nuclear reprogramming efficiency. KDM6A overexpression enhanced the transcription of genes involved in cell adhesion and cellular metabolism and X-linked genes. MBD3L(3) was reactivated by KDM6A., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:0071558 histone H3K27me2/H3K27me3 demethylase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0044666 MLL3/4 complex;GO:0005634 nucleus;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0007507 heart development;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3N2E9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1D2-1", "uniprot_id": [ { "id": "F1N1D2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1D2", "type": "external" } ], "mass": 37698.0, "length": 340, "protein_name": "Meiotic recombination protein", "gene_name": "DMC1", "organism": "Bovine", "refseq_name": "meiotic recombination protein DMC1/LIM15 homolog", "refseq_ac": [ { "id": "NP_001178267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178267", "type": "external" } ], "gene_names_uniprotkb": "DMC1", "gene_names_refseq": "DCM1; DMC1", "protein_names_uniprotkb": "Meiotic recombination protein", "protein_names_refseq": "meiotic recombination protein DMC1/LIM15 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:618398); (R-BTA-912446)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks., [UniProtKB, UniProtKB, UniProtKB]; Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0140664 ATP-dependent DNA damage sensor activity;GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000794 condensed nuclear chromosome;GO:0035861 site of double-strand break;GO:0000800 lateral element;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0051321 meiotic cell cycle;GO:0006312 mitotic recombination;GO:0007283 spermatogenesis;GO:1990918 double-strand break repair involved in meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N1D2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MWN5-1", "uniprot_id": [ { "id": "F1MWN5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MWN5", "type": "external" } ], "mass": 64856.0, "length": 585, "protein_name": "Folylpolyglutamate synthase", "gene_name": "FPGS", "organism": "Bovine", "refseq_name": "folylpolyglutamate synthase, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_059747060", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747060", "type": "external" } ], "gene_names_uniprotkb": "FPGS", "gene_names_refseq": "FPGS", "protein_names_uniprotkb": "Folylpolyglutamate synthase; 6.3.2.17; Folylpoly-gamma-glutamate synthetase; Tetrahydrofolylpolyglutamate synthase", "protein_names_refseq": "folylpolyglutamate synthase, mitochondrial isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-196757)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004326 tetrahydrofolylpolyglutamate synthase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0006536 glutamate metabolic process;GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MWN5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22439-1", "uniprot_id": [ { "id": "ODPX_BOVIN", "url": "https://www.uniprot.org/uniprot/P22439", "type": "external" } ], "mass": 53886.0, "length": 501, "protein_name": "Pyruvate dehydrogenase protein X component", "gene_name": "PDHX", "organism": "Bovine", "refseq_name": "pyruvate dehydrogenase protein X component precursor", "refseq_ac": [ { "id": "NP_001069219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069219", "type": "external" } ], "gene_names_uniprotkb": "PDHX; PDX1", "gene_names_refseq": "PDHX", "protein_names_uniprotkb": "Pyruvate dehydrogenase protein X component; Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; E3-binding protein; E3BP; proX", "protein_names_refseq": "E3-binding protein; E3BP; dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; proX; pyruvate dehydrogenase protein X component precursor; pyruvate dehydrogenase protein X component-like; pyruvate dehydrogenase protein X component", "tax_id": 9913, "disease": "", "pathway": " (bta:517402); (R-BTA-204174); (R-BTA-5362517); (R-BTA-9861559)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1505515;20361979;21627584;2759236;2914903", "class_list": "", "function": "Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex., [UniProtKB]; This study showed that the recombinant and bovine E2/E3BP cores bind E3s with a 2:1 stoichiometry, and propose that mammalian PDC comprises a heterogeneous population of assemblies incorporating a network of E3 cross-bridges above the core surface., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0P576", "ec_number_list": [], "go_molecular_function": "GO:0016746 acyltransferase activity;GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P22439-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42659-1", "uniprot_id": [ { "id": "DPP6_BOVIN", "url": "https://www.uniprot.org/uniprot/P42659", "type": "external" } ], "mass": 96557.0, "length": 863, "protein_name": "A-type potassium channel modulatory protein DPP6", "gene_name": "DPP6", "organism": "Bovine", "refseq_name": "A-type potassium channel modulatory protein DPP6", "refseq_ac": [ { "id": "NP_776465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776465", "type": "external" } ], "gene_names_uniprotkb": "DPP6", "gene_names_refseq": "DPP VI; DPP6", "protein_names_uniprotkb": "A-type potassium channel modulatory protein DPP6; DPP VI; DPPX; Dipeptidyl aminopeptidase-like protein 6; Dipeptidyl aminopeptidase-related protein; Dipeptidyl peptidase 6; Dipeptidyl peptidase IV-like protein; Dipeptidyl peptidase VI", "protein_names_refseq": "A-type potassium channel modulatory protein DPP6; DPPX; dipeptidyl aminopeptidase-like protein 6; dipeptidyl aminopeptidase-related protein; dipeptidyl peptidase 6; dipeptidyl peptidase IV-like protein; dipeptidyl peptidase VI; dipeptidylpeptidase 6; dipeptidylpeptidase VI", "tax_id": 9913, "disease": "", "pathway": " (bta:281123)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1729689;37917556", "class_list": "", "function": "Polymorphism of ADAM12, DPP6 and PRKN genes and their associations with milk production traits in Holstein., [RefSeq, PubMed]; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates the activity and gating characteristics of the potassium channel KCND2 amd KCND3. Promotes cell surface expression of the potassium channel KCND2 (By similarity). Has no dipeptidyl aminopeptidase activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0006508 proteolysis;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P42659-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13600-1", "uniprot_id": [ { "id": "NGF_BOVIN", "url": "https://www.uniprot.org/uniprot/P13600", "type": "external" } ], "mass": 26669.0, "length": 241, "protein_name": "Beta-nerve growth factor", "gene_name": "NGF", "organism": "Bovine", "refseq_name": "beta-nerve growth factor precursor", "refseq_ac": [ { "id": "NP_001092832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092832", "type": "external" } ], "gene_names_uniprotkb": "NGF; NGFB", "gene_names_refseq": "NGFB; NGF", "protein_names_uniprotkb": "Beta-nerve growth factor; Beta-NGF", "protein_names_refseq": "beta-NGF; beta-nerve growth factor precursor; beta-nerve growth factor; nerve growth factor, beta polypeptide", "tax_id": 9913, "disease": "", "pathway": " (bta:281350); (R-BTA-1257604); (R-BTA-167060); (R-BTA-170968); (R-BTA-170984); (R-BTA-177504); (R-BTA-187042); (R-BTA-198203); (R-BTA-205017); (R-BTA-205025); (R-BTA-205043); (R-BTA-209543); (R-BTA-209560); (R-BTA-209563)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "2427334;9284944", "class_list": "", "function": "Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6X9;O18969", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding;GO:0008191 metalloendopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031904 endosome lumen;GO:0008021 synaptic vesicle;GO:0005576 extracellular region", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0048812 neuron projection morphogenesis;GO:0043524 negative regulation of neuron apoptotic process;GO:0050804 modulation of chemical synaptic transmission;GO:0021675 nerve development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P13600-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N549-1", "uniprot_id": [ { "id": "F1N549_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N549", "type": "external" } ], "mass": 111838.0, "length": 1025, "protein_name": "Dihydropyrimidine dehydrogenase [NADP(+)]", "gene_name": "DPYD", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DPYD", "gene_names_refseq": "", "protein_names_uniprotkb": "Dihydropyrimidine dehydrogenase [NADP(+)]; 1.3.1.2; DHPDHase; DPD; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-73621)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0050661 NADP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0019483 beta-alanine biosynthetic process;GO:0046079 dUMP catabolic process;GO:0006145 purine nucleobase catabolic process;GO:0006210 thymine catabolic process;GO:0006212 uracil catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N549-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E518-1", "uniprot_id": [ { "id": "G5E518_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E518", "type": "external" } ], "mass": 164125.0, "length": 1490, "protein_name": "Cyclin-dependent kinase 12", "gene_name": "CDK12", "organism": "Bovine", "refseq_name": "cyclin-dependent kinase 12", "refseq_ac": [ { "id": "NP_001192630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192630", "type": "external" } ], "gene_names_uniprotkb": "CDK12", "gene_names_refseq": "CDK12; CRKRS", "protein_names_uniprotkb": "Cyclin-dependent kinase 12; 2.7.11.22; 2.7.11.23; Cell division protein kinase 12", "protein_names_refseq": "Cdc2-related kinase, arginine/serine-rich; cell division protein kinase 12; cyclin-dependent kinase 12", "tax_id": 9913, "disease": "", "pathway": " (bta:511513); (R-BTA-6796648)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0019901 protein kinase binding;GO:0030332 cyclin binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005634 nucleus;GO:0002944 cyclin K-CDK12 complex;GO:0008024 cyclin/CDK positive transcription elongation factor complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006366 transcription by RNA polymerase II;GO:0071391 cellular response to estrogen stimulus;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E518-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N184-1", "uniprot_id": [ { "id": "G3N184_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N184", "type": "external" } ], "mass": 37100.0, "length": 328, "protein_name": "Nuclear distribution protein nudE-like 1", "gene_name": "NDEL1", "organism": "Bovine", "refseq_name": "nuclear distribution protein nudE-like 1 isoform X2", "refseq_ac": [ { "id": "XP_005220398", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220398", "type": "external" } ], "gene_names_uniprotkb": "NDEL1", "gene_names_refseq": "NDEL1", "protein_names_uniprotkb": "Nuclear distribution protein nudE-like 1", "protein_names_refseq": "nuclear distribution protein nudE-like 1 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:510769); (R-BTA-141430); (R-BTA-141444); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-5663220); (R-BTA-9648025)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0000776 kinetochore;GO:0031252 cell leading edge", "go_biological_process": "GO:0007399 nervous system development;GO:0021799 cerebral cortex radially oriented cell migration;GO:0007059 chromosome segregation;GO:0016477 cell migration;GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N184-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6PYA5-1", "uniprot_id": [ { "id": "F6PYA5_BOVIN", "url": "https://www.uniprot.org/uniprot/F6PYA5", "type": "external" } ], "mass": 105125.0, "length": 957, "protein_name": "Low-density lipoprotein receptor-related protein 8", "gene_name": "LRP8", "organism": "Bovine", "refseq_name": "low-density lipoprotein receptor-related protein 8 isoform X6", "refseq_ac": [ { "id": "XP_024841059", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841059", "type": "external" } ], "gene_names_uniprotkb": "LRP8", "gene_names_refseq": "LRP8", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 8; Apolipoprotein E receptor 2", "protein_names_refseq": "low-density lipoprotein receptor-related protein 8 isoform X6", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-432142); (R-BTA-975634)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004888 transmembrane signaling receptor activity;GO:0034185 apolipoprotein binding;GO:0005041 low-density lipoprotein particle receptor activity;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005901 caveola;GO:0098978 glutamatergic synapse;GO:0005615 extracellular space", "go_biological_process": "GO:0006897 endocytosis;GO:0021517 ventral spinal cord development;GO:0007165 signal transduction;GO:0007268 chemical synaptic transmission;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6PYA5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01035-1", "uniprot_id": [ { "id": "CYTC_BOVIN", "url": "https://www.uniprot.org/uniprot/P01035", "type": "external" } ], "mass": 16265.0, "length": 148, "protein_name": "Cystatin-C", "gene_name": "CST3", "organism": "Bovine", "refseq_name": "cystatin-C precursor", "refseq_ac": [ { "id": "NP_776454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776454", "type": "external" } ], "gene_names_uniprotkb": "CST3", "gene_names_refseq": "CST3", "protein_names_uniprotkb": "Cystatin-C; Colostrum thiol proteinase inhibitor; Cystatin-3", "protein_names_refseq": "colostrum thiol proteinase inhibitor; cystatin C (amyloid angiopathy and cerebral hemorrhage); cystatin-3; cystatin-C precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281102); (R-BTA-381426); (R-BTA-6798695); (R-BTA-8957275)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "12596844;12658628;3891407;9434110", "class_list": "", "function": "Cystatin C in milk basic protein (MBP) is suggested as one of the factors inhibiting bone resorption, [RefSeq, PubMed]; This is a thiol proteinase inhibitor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q54A26", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031982 vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P01035-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MS08-1", "uniprot_id": [ { "id": "F1MS08_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MS08", "type": "external" } ], "mass": 130731.0, "length": 1204, "protein_name": "Solute carrier family 12 member 2", "gene_name": "SLC12A2", "organism": "Bovine", "refseq_name": "solute carrier family 12 member 2 isoform X1", "refseq_ac": [ { "id": "XP_005209143", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209143", "type": "external" } ], "gene_names_uniprotkb": "SLC12A2", "gene_names_refseq": "SLC12A2; bsc2", "protein_names_uniprotkb": "Solute carrier family 12 member 2", "protein_names_refseq": "solute carrier family 12 member 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-426117)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008511 sodium:potassium:chloride symporter activity;GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0051879 Hsp90 protein binding;GO:0008519 ammonium channel activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0043025 neuronal cell body;GO:0030659 cytoplasmic vesicle membrane;GO:0043005 neuron projection;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0070634 transepithelial ammonium transport;GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MS08-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N4E5-1", "uniprot_id": [ { "id": "TOIP1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N4E5", "type": "external" } ], "mass": 67468.0, "length": 600, "protein_name": "Torsin-1A-interacting protein 1", "gene_name": "TOR1AIP1", "organism": "Bovine", "refseq_name": "torsin-1A-interacting protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001422001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422001", "type": "external" } ], "gene_names_uniprotkb": "TOR1AIP1", "gene_names_refseq": "LAP1B; TOR1AIP1", "protein_names_uniprotkb": "Torsin-1A-interacting protein 1; LAP1B; Lamin-associated protein 1B", "protein_names_refseq": "Lamin-associated protein 1B; Torsin-1A-interacting protein 1; torsin A interacting protein 1; torsin-1A-interacting protein 1 isoform 2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9035034)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001671 ATPase activator activity;GO:0051117 ATPase binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0034504 protein localization to nucleus;GO:0032781 positive regulation of ATP-dependent activity;GO:0071763 nuclear membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1N4E5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MX04-1", "uniprot_id": [ { "id": "F1MX04_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MX04", "type": "external" } ], "mass": 176585.0, "length": 1607, "protein_name": "Eukaryotic translation initiation factor 4 gamma 1", "gene_name": "EIF4G1", "organism": "Bovine", "refseq_name": "eukaryotic translation initiation factor 4 gamma 1 isoform X2", "refseq_ac": [ { "id": "XP_024851080", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851080", "type": "external" } ], "gene_names_uniprotkb": "EIF4G1", "gene_names_refseq": "EIF4G1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4 gamma 1", "protein_names_refseq": "eukaryotic translation initiation factor 4 gamma 1 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1169408); (R-BTA-156827); (R-BTA-166208); (R-BTA-429947); (R-BTA-450408); (R-BTA-72649); (R-BTA-72702); (R-BTA-975956); (R-BTA-975957)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0008190 eukaryotic initiation factor 4E binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016281 eukaryotic translation initiation factor 4F complex;GO:0005840 ribosome", "go_biological_process": "GO:0006417 regulation of translation;GO:0030307 positive regulation of cell growth;GO:0097009 energy homeostasis;GO:0006413 translational initiation;GO:0010507 negative regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MX04-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46414-1", "uniprot_id": [ { "id": "FRIH_BOVIN", "url": "https://www.uniprot.org/uniprot/O46414", "type": "external" } ], "mass": 21052.0, "length": 181, "protein_name": "Ferritin heavy chain", "gene_name": "FTH1", "organism": "Bovine", "refseq_name": "ferritin heavy chain", "refseq_ac": [ { "id": "NP_776487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776487", "type": "external" } ], "gene_names_uniprotkb": "FTH1; FTH", "gene_names_refseq": "FTH1; FTH", "protein_names_uniprotkb": "Ferritin heavy chain; 1.16.3.1; Ferritin H subunit", "protein_names_refseq": "ferritin H subunit; ferritin heavy chain; ferritin protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281173); (R-BTA-6798695); (R-BTA-917937)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "19596355;36706507;9467878", "class_list": "", "function": "Ferritin heavy chain up-regulation may be mediated by activation of NF-kappaB and that in turn this may be related to the resistance of bovine papillomavirus type-2 (BPV-2) infected urothelial cells to apoptosis., [RefSeq, PubMed]; Ferritin-dependent cellular autophagy pathway promotes ferroptosis in beef during cold storage., [RefSeq, PubMed]; Stores iron in a soluble, non-toxic, readily available form (By similarity). Important for iron homeostasis (By similarity). Has ferroxidase activity (By similarity). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron., [UniProtKB, UniProtKB]; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q56JZ8", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0004322 ferroxidase activity;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome", "go_biological_process": "GO:0006955 immune response;GO:0008285 negative regulation of cell population proliferation;GO:0006879 intracellular iron ion homeostasis;GO:0006826 iron ion transport;GO:0110076 negative regulation of ferroptosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O46414-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N0D7-1", "uniprot_id": [ { "id": "G3N0D7_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N0D7", "type": "external" } ], "mass": 112330.0, "length": 1008, "protein_name": "E3 ubiquitin-protein ligase CBL", "gene_name": "CBLB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CBLB", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CBL; 2.3.2.27", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:525906)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0016567 protein ubiquitination;GO:0023051 regulation of signaling;GO:0050821 protein stabilization;GO:0070534 protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N0D7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20616-1", "uniprot_id": [ { "id": "SCG2_BOVIN", "url": "https://www.uniprot.org/uniprot/P20616", "type": "external" } ], "mass": 70346.0, "length": 613, "protein_name": "Secretogranin-2", "gene_name": "SCG2", "organism": "Bovine", "refseq_name": "secretogranin-2 precursor", "refseq_ac": [ { "id": "NP_776601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776601", "type": "external" } ], "gene_names_uniprotkb": "SCG2; CHGC", "gene_names_refseq": "SCG2", "protein_names_uniprotkb": "Secretogranin-2; Chromogranin-C; Secretogranin II; SgII", "protein_names_refseq": "chromogranin-C; secretogranin II (chromogranin C); secretogranin-2 precursor; secretogranin-2; sgII", "tax_id": 9913, "disease": "", "pathway": " (bta:281477); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16888183;18020452;2345170;8492910;9654353", "class_list": "", "function": "Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results show the localization of secretogranin II (SgII) in the nucleus, more specifically, in the IP3-sensitive nucleoplasmic Ca2+ store vesicles along with CGB and the IP3 receptors., [RefSeq, PubMed]; Secretogranin II-derived peptide EM66 may act downstream of the trans-synaptic stimulation of the adrenal medulla by neurocrine factors, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBY6", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0005576 extracellular region", "go_biological_process": "GO:0001525 angiogenesis;GO:0035556 intracellular signal transduction;GO:0000165 MAPK cascade;GO:0001938 positive regulation of endothelial cell proliferation;GO:2000352 negative regulation of endothelial cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P20616-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MWM8-1", "uniprot_id": [ { "id": "G3MWM8_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MWM8", "type": "external" } ], "mass": 57035.0, "length": 523, "protein_name": "Wilms tumor protein homolog", "gene_name": "WT1", "organism": "Bovine", "refseq_name": "WT1 transcription factor", "refseq_ac": [ { "id": "NP_001422850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422850", "type": "external" } ], "gene_names_uniprotkb": "WT1", "gene_names_refseq": "WT1; WT", "protein_names_uniprotkb": "Wilms tumor protein homolog", "protein_names_refseq": "WT1 transcription factor; Wilms tumor 1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "31302435;31490589", "class_list": "", "function": "The results suggest that WT1 is involved in the differentiation of cortical stromal cells into cells with characteristics similar to theca cells of antral follicles in adult bovine ovaries., [RefSeq, PubMed]; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; WT1 mediates the regulation of several proteins involved in bovine Sertoli cells polarity maintenance and intercellular tight junctions (TJ) by non-canonical WNT signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0072359 circulatory system development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3MWM8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N020-1", "uniprot_id": [ { "id": "F1N020_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N020", "type": "external" } ], "mass": 84909.0, "length": 743, "protein_name": "Kinesin-like protein", "gene_name": "KIF3B", "organism": "Bovine", "refseq_name": "kinesin-like protein KIF3B", "refseq_ac": [ { "id": "NP_001104258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104258", "type": "external" } ], "gene_names_uniprotkb": "KIF3B", "gene_names_refseq": "KIF3B", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin-like protein KIF3B", "tax_id": 9913, "disease": "", "pathway": " (bta:508404)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule. Plays a role in cilia formation. Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors. Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity;GO:0031267 small GTPase binding;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0043005 neuron projection;GO:0016939 kinesin II complex;GO:0098978 glutamatergic synapse", "go_biological_process": "GO:0008088 axo-dendritic transport;GO:0060271 cilium assembly;GO:0090307 mitotic spindle assembly;GO:0016192 vesicle-mediated transport;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N020-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F2Z4I5-1", "uniprot_id": [ { "id": "F2Z4I5_BOVIN", "url": "https://www.uniprot.org/uniprot/F2Z4I5", "type": "external" } ], "mass": 27820.0, "length": 246, "protein_name": "ADP-ribosylation factor-like protein 8B", "gene_name": "ARL8B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ARL8B", "gene_names_refseq": "", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 8B", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0048487 beta-tubulin binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005819 spindle;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0051301 cell division;GO:0008089 anterograde axonal transport;GO:0001778 plasma membrane repair;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F2Z4I5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1Z7-1", "uniprot_id": [ { "id": "F1N1Z7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1Z7", "type": "external" } ], "mass": 68219.0, "length": 612, "protein_name": "Phosphoenolpyruvate carboxykinase, cytosolic [GTP]", "gene_name": "PCK1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PCK1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; 4.1.1.32; Serine-protein kinase PCK1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0016301 kinase activity;GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity;GO:0000287 magnesium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0043648 dicarboxylic acid metabolic process;GO:0006094 gluconeogenesis;GO:0032869 cellular response to insulin stimulus;GO:0071333 cellular response to glucose stimulus;GO:0046889 positive regulation of lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N1Z7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0QW12-1", "uniprot_id": [ { "id": "M0QW12_BOVIN", "url": "https://www.uniprot.org/uniprot/M0QW12", "type": "external" } ], "mass": 228886.0, "length": 2009, "protein_name": "Sodium channel protein", "gene_name": "SCN1A", "organism": "Bovine", "refseq_name": "sodium channel protein type 1 subunit alpha isoform X5", "refseq_ac": [ { "id": "XP_059731031", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731031", "type": "external" } ], "gene_names_uniprotkb": "SCN1A", "gene_names_refseq": "SCN1A", "protein_names_uniprotkb": "Sodium channel protein", "protein_names_refseq": "sodium channel protein type 1 subunit alpha isoform X5", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5576892)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0001518 voltage-gated sodium channel complex;GO:0043025 neuronal cell body;GO:0014704 intercalated disc;GO:0030018 Z disc;GO:0030315 T-tubule", "go_biological_process": "GO:0086010 membrane depolarization during action potential;GO:0050966 detection of mechanical stimulus involved in sensory perception of pain;GO:0035725 sodium ion transmembrane transport;GO:0086002 cardiac muscle cell action potential involved in contraction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0QW12-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35720-1", "uniprot_id": [ { "id": "C560_BOVIN", "url": "https://www.uniprot.org/uniprot/P35720", "type": "external" } ], "mass": 18389.0, "length": 169, "protein_name": "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial", "gene_name": "SDHC", "organism": "Bovine", "refseq_name": "succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor", "refseq_ac": [ { "id": "NP_787008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787008", "type": "external" } ], "gene_names_uniprotkb": "SDHC; CYB560", "gene_names_refseq": "QPs1; SDHC", "protein_names_uniprotkb": "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Integral membrane protein CII-3; Malate dehydrogenase [quinone] cytochrome b560 subunit; QPs-1; QPs1; Succinate dehydrogenase complex subunit C", "protein_names_refseq": "integral membrane protein CII-3; malate dehydrogenase [quinone] cytochrome b560 subunit; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa; succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor; succinate dehydrogenase cytochrome b560 subunit, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:327696); (R-BTA-71403); (R-BTA-9854311)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1447196;16305752;16717460;1864383;2902878;7890754;7947903", "class_list": "", "function": "Assignment to chromosome 2, [RefSeq, PubMed]; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (PubMed:1864383, PubMed:2902878). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (PubMed:2902878)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1JP77;Q3T194;Q9T2T6", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase);GO:0016020 membrane", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006121 mitochondrial electron transport, succinate to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P35720-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11966-1", "uniprot_id": [ { "id": "ODPB_BOVIN", "url": "https://www.uniprot.org/uniprot/P11966", "type": "external" } ], "mass": 39126.0, "length": 359, "protein_name": "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial", "gene_name": "PDHB", "organism": "Bovine", "refseq_name": "pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001030512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030512", "type": "external" } ], "gene_names_uniprotkb": "PDHB", "gene_names_refseq": "PDHB", "protein_names_uniprotkb": "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; 1.2.4.1; PDHE1-B", "protein_names_refseq": "PDHE1-B; pyruvate dehydrogenase (lipoamide) beta; pyruvate dehydrogenase E1 beta subunit; pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor; pyruvate dehydrogenase E1 component subunit beta, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:613610); (R-BTA-204174); (R-BTA-5362517); (R-BTA-9837999); (R-BTA-9861559)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "16305752;21469508;27379520;2829898", "class_list": "", "function": "Data indicate the pyruvate dehydrogenase-E1 beta core promoter to be located 490bp upstream from the transcription initiation site (+1). Publication Status: Online-Only, [RefSeq, PubMed]; Polymorphisms in promoter regions of PDHB, SORBS1, and EDG1 genes showing marbling-associated expression changes., [RefSeq, PubMed]; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2., [UniProtKB, UniProtKB, UniProtKB]; Together with PDHA1 forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex. The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QQW6;Q58CN6", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0045254 pyruvate dehydrogenase complex;GO:0005739 mitochondrion", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006006 glucose metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P11966-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13621-1", "uniprot_id": [ { "id": "ATPO_BOVIN", "url": "https://www.uniprot.org/uniprot/P13621", "type": "external" } ], "mass": 23320.0, "length": 213, "protein_name": "ATP synthase peripheral stalk subunit OSCP, mitochondrial", "gene_name": "ATP5PO", "organism": "Bovine", "refseq_name": "ATP synthase peripheral stalk subunit OSCP, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776669", "type": "external" } ], "gene_names_uniprotkb": "ATP5PO; ATP5O", "gene_names_refseq": "ATP5O; ATP5PO; OSCP", "protein_names_uniprotkb": "ATP synthase peripheral stalk subunit OSCP, mitochondrial; ATP synthase subunit O; OSCP; Oligomycin sensitivity conferral protein", "protein_names_refseq": "ATP synthase peripheral stalk subunit OSCP, mitochondrial precursor; ATP synthase peripheral stalk subunit OSCP, mitochondrial; ATP synthase subunit O, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein); oligomycin sensitivity conferral protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281640); (R-BTA-163210); (R-BTA-8949613); (R-BTA-9837999)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "17355883;17570365;1827992;25851905;28100784;2894843", "class_list": "", "function": "Nuclear magnetic resonance characterisation of the interaction between OSCP-N terminal and a peptide corresponding to residues 1-25 of the alpha-subunit of bovine F(1)-ATPase, is presented., [RefSeq, PubMed]; Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (Probable)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0Y7", "ec_number_list": [], "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P13621-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E5P3-1", "uniprot_id": [ { "id": "G5E5P3_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E5P3", "type": "external" } ], "mass": 47487.0, "length": 428, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 5", "gene_name": "ENTPD5", "organism": "Bovine", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 5 precursor", "refseq_ac": [ { "id": "NP_001179681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179681", "type": "external" } ], "gene_names_uniprotkb": "ENTPD5", "gene_names_refseq": "ENTPD5", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 5; 3.6.1.6; Guanosine-diphosphatase ENTPD5; Uridine-diphosphatase ENTPD5", "protein_names_refseq": "GDPase ENTPD5; NTPDase 5; UDPase ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 precursor; guanosine-diphosphatase ENTPD5; uridine-diphosphatase ENTPD5", "tax_id": 9913, "disease": "", "pathway": " (bta:533096); (R-BTA-8850843)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP. In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.64", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.16", "type": "external" }, { "id": "3.6.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.53", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0017110 nucleoside diphosphate phosphatase activity;GO:0004382 GDP phosphatase activity;GO:0043262 ADP phosphatase activity;GO:0045134 UDP phosphatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005615 extracellular space", "go_biological_process": "GO:0006256 UDP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E5P3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E618-1", "uniprot_id": [ { "id": "G5E618_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E618", "type": "external" } ], "mass": 226361.0, "length": 2176, "protein_name": "SH3 and multiple ankyrin repeat domains protein 1", "gene_name": "SHANK1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SHANK1", "gene_names_refseq": "", "protein_names_uniprotkb": "SH3 and multiple ankyrin repeat domains protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6794361)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 0, "predicted_o_glycosites": 13, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035255 ionotropic glutamate receptor binding;GO:0098919 structural constituent of postsynaptic density;GO:0030160 synaptic receptor adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0098978 glutamatergic synapse;GO:0043197 dendritic spine", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0042048 olfactory behavior;GO:0046959 habituation;GO:0050894 determination of affect", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E618-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N399-1", "uniprot_id": [ { "id": "F1N399_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N399", "type": "external" } ], "mass": 59850.0, "length": 530, "protein_name": "Sorting nexin-1", "gene_name": "SNX1", "organism": "Bovine", "refseq_name": "sorting nexin-1 isoform X1", "refseq_ac": [ { "id": "XP_010807549", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807549", "type": "external" } ], "gene_names_uniprotkb": "SNX1", "gene_names_refseq": "SNX1", "protein_names_uniprotkb": "Sorting nexin-1", "protein_names_refseq": "sorting nexin-1 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0005158 insulin receptor binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030027 lamellipodium;GO:0031901 early endosome membrane;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0015031 protein transport;GO:0031623 receptor internalization;GO:0072673 lamellipodium morphogenesis;GO:0034498 early endosome to Golgi transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N399-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N5Q5-1", "uniprot_id": [ { "id": "F1N5Q5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N5Q5", "type": "external" } ], "mass": 101444.0, "length": 882, "protein_name": "Vacuolar protein sorting-associated protein 11 homolog", "gene_name": "VPS11", "organism": "Bovine", "refseq_name": "vacuolar protein sorting-associated protein 11 homolog isoform X2", "refseq_ac": [ { "id": "XP_024831231", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831231", "type": "external" } ], "gene_names_uniprotkb": "VPS11", "gene_names_refseq": "VPS11", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 11 homolog", "protein_names_refseq": "vacuolar protein sorting-associated protein 11 homolog isoform X2", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000166 nucleotide binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005769 early endosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006914 autophagy;GO:0016192 vesicle-mediated transport;GO:0048284 organelle fusion;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N5Q5-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N1H2-1", "uniprot_id": [ { "id": "G3N1H2_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N1H2", "type": "external" } ], "mass": 129744.0, "length": 1185, "protein_name": "Metabotropic glutamate receptor 5", "gene_name": "GRM5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GRM5", "gene_names_refseq": "", "protein_names_uniprotkb": "Metabotropic glutamate receptor 5", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-416476); (R-BTA-420499); (R-BTA-6794361)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0030296 protein tyrosine kinase activator activity;GO:0008066 glutamate receptor activity;GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0005737 cytoplasm;GO:0098839 postsynaptic density membrane;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway;GO:1902533 positive regulation of intracellular signal transduction;GO:0007611 learning or memory;GO:0050808 synapse organization;GO:1904646 cellular response to amyloid-beta", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N1H2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N4H9-1", "uniprot_id": [ { "id": "F1N4H9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N4H9", "type": "external" } ], "mass": 67334.0, "length": 582, "protein_name": "Alpha-(1,6)-fucosyltransferase", "gene_name": "FUT8", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FUT8", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-(1,6)-fucosyltransferase; 2.4.1.68", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-975578)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Fucosylates the reducing GlcNAc residue in complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs. Fully converts Fc glycoforms containing one or two terminal GlcNAc moieties (G0-GlcNAc and G0)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.68", "type": "external" } ], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity;GO:0046921 alpha-(1->6)-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0046368 GDP-L-fucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N4H9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F2Z4J0-1", "uniprot_id": [ { "id": "F2Z4J0_BOVIN", "url": "https://www.uniprot.org/uniprot/F2Z4J0", "type": "external" } ], "mass": 23921.0, "length": 207, "protein_name": "Fibroblast growth factor", "gene_name": "FGF18", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FGF18", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibroblast growth factor; FGF", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-109704); (R-BTA-1257604); (R-BTA-190322); (R-BTA-190371); (R-BTA-190372); (R-BTA-190375); (R-BTA-5654221); (R-BTA-5654227); (R-BTA-5654228); (R-BTA-5654695); (R-BTA-5654699); (R-BTA-5654700); (R-BTA-5654704); (R-BTA-5654706); (R-BTA-5654710); (R-BTA-5654712); (R-BTA-5654719); (R-BTA-5654720); (R-BTA-5654727); (R-BTA-5654732); (R-BTA-5654733); (R-BTA-5658623); (R-BTA-5673001); (R-BTA-6811558)", "pathway_count": 24, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0005111 type 2 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0045766 positive regulation of angiogenesis;GO:0030334 regulation of cell migration;GO:0043536 positive regulation of blood vessel endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F2Z4J0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11019-1", "uniprot_id": [ { "id": "VATE1_BOVIN", "url": "https://www.uniprot.org/uniprot/P11019", "type": "external" } ], "mass": 26139.0, "length": 226, "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "ATP6V1E1", "organism": "Bovine", "refseq_name": "V-type proton ATPase subunit E 1", "refseq_ac": [ { "id": "NP_777235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777235", "type": "external" } ], "gene_names_uniprotkb": "ATP6V1E1; ATP6E", "gene_names_refseq": "ATP6V1E1", "protein_names_uniprotkb": "V-type proton ATPase subunit E 1; P31; V-ATPase 31 kDa subunit; V-ATPase subunit E 1; Vacuolar proton pump subunit E 1", "protein_names_refseq": "ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1; P31; V-ATPase 31 kDa subunit; V-ATPase subunit E 1; V-type proton ATPase subunit E 1; vacuolar H+ ATPase E1; vacuolar proton pump subunit E 1", "tax_id": 9913, "disease": "", "pathway": " (bta:287017); (R-BTA-1222556); (R-BTA-77387); (R-BTA-917977); (R-BTA-9639288); (R-BTA-983712)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "2896353;32764564", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T009", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0016324 apical plasma membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0045851 pH reduction;GO:1902600 proton transmembrane transport;GO:0097401 synaptic vesicle lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P11019-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41984-1", "uniprot_id": [ { "id": "ACM3_BOVIN", "url": "https://www.uniprot.org/uniprot/P41984", "type": "external" } ], "mass": 66103.0, "length": 590, "protein_name": "Muscarinic acetylcholine receptor M3", "gene_name": "CHRM3", "organism": "Bovine", "refseq_name": "muscarinic acetylcholine receptor M3", "refseq_ac": [ { "id": "NP_776695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776695", "type": "external" } ], "gene_names_uniprotkb": "CHRM3", "gene_names_refseq": "CHRM3", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M3", "protein_names_refseq": "muscarinic acetylcholine receptor M3", "tax_id": 9913, "disease": "", "pathway": " (bta:281685); (R-BTA-390648); (R-BTA-416476)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17613728;18524769;23396229;8061048", "class_list": "", "function": "Airway M(2)Rs inhibit BK channels by a dual, Gbetagamma-mediated mechanism, a direct membrane-delimited interaction, and the activation of the phospholipase C/protein kinase C pathway, [RefSeq, PubMed]; Sequential activation of muscarinic M3 receptors and cannabinoid CB1 receptors produce synergistic contractile effects of the bovine ciliary muscle by involving the activation of Rho-kinase and protein kinase C., [RefSeq, PubMed]; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data support the existence of a novel transducing cascade, involving Galpha(q16)beta gamma coupling M(3)AChR to NPR-GC., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016907 G protein-coupled acetylcholine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045211 postsynaptic membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030425 dendrite", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0045987 positive regulation of smooth muscle contraction;GO:0046541 saliva secretion;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0006940 regulation of smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P41984-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MS15-1", "uniprot_id": [ { "id": "PKHA8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MS15", "type": "external" } ], "mass": 58270.0, "length": 520, "protein_name": "Pleckstrin homology domain-containing family A member 8", "gene_name": "PLEKHA8", "organism": "Bovine", "refseq_name": "pleckstrin homology domain-containing family A member 8", "refseq_ac": [ { "id": "NP_001183961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001183961", "type": "external" } ], "gene_names_uniprotkb": "PLEKHA8; FAPP2", "gene_names_refseq": "FAPP-2; PLEKHA8", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 8; FAPP-2; PH domain-containing family A member 8; Phosphatidylinositol-four-phosphate adapter protein 2; Phosphoinositol 4-phosphate adapter protein 2", "protein_names_refseq": "PH domain-containing family A member 8; phosphatidylinositol-four-phosphate adapter protein 2; phosphoinositol 4-phosphate adapter protein 2; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; pleckstrin homology domain-containing family A member 8", "tax_id": 9913, "disease": "", "pathway": " (bta:538919); (R-BTA-1660499); (R-BTA-9845576)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane, playing a pivotal role in the synthesis of complex glycosphingolipids; binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for this GlcCer transfer ability (By similarity). Also functions as a cargo transport protein required for apical transport from the Golgi complex, including transport of AQP2 from the TGN to sites of AQP2 phosphorylation. Additionally required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0097001 ceramide binding;GO:1902387 ceramide 1-phosphate binding;GO:1902388 ceramide 1-phosphate transfer activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0005802 trans-Golgi network;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001576 globoside biosynthetic process;GO:0006869 lipid transport;GO:0015031 protein transport;GO:0035621 ER to Golgi ceramide transport;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MS15-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14893-1", "uniprot_id": [ { "id": "3BHS_BOVIN", "url": "https://www.uniprot.org/uniprot/P14893", "type": "external" } ], "mass": 42220.0, "length": 373, "protein_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase", "gene_name": "HSD3B1; HSD3B", "organism": "Bovine", "refseq_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase", "refseq_ac": [ { "id": "NP_776768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776768", "type": "external" } ], "gene_names_uniprotkb": "HSD3B1; HSD3B", "gene_names_refseq": "HSD3B1; HSD3B", "protein_names_uniprotkb": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD; 3-beta-hydroxy-5-ene steroid dehydrogenase; Delta-5-3-ketosteroid isomerase; Progesterone reductase", "protein_names_refseq": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD; hydroxy-delta-MAY-steroid dehydrogenase, 3 beta- and steroid delta-isomerase", "tax_id": 9913, "disease": "", "pathway": " (bta:281824); (R-BTA-193048); (R-BTA-193993); (R-BTA-194002)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "16717461;18455233;1868086;21069797;2599102", "class_list": "", "function": "3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1, HSD3B1, and CYP17A1 transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined., [RefSeq, PubMed]; Mapped bo bovine chromosome 3, [RefSeq, PubMed]; Serum free culture conditions significantly enhanced Cyp17 and Csh1 but not Hsd3b expression in trophoblast., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2T9Y8", "ec_number_list": [ { "id": "1.1.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145", "type": "external" }, { "id": "5.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1", "type": "external" } ], "go_molecular_function": "GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity;GO:0004769 steroid Delta-isomerase activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031966 mitochondrial membrane;GO:0030868 smooth endoplasmic reticulum membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0008207 C21-steroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P14893-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N5V1-1", "uniprot_id": [ { "id": "UBP37_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N5V1", "type": "external" } ], "mass": 110398.0, "length": 981, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 37", "gene_name": "USP37", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 37", "refseq_ac": [ { "id": "NP_001258921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258921", "type": "external" } ], "gene_names_uniprotkb": "USP37", "gene_names_refseq": "USP37", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 37; 3.4.19.12; Deubiquitinating enzyme 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37", "protein_names_refseq": "deubiquitinating enzyme 37; ubiquitin carboxyl-terminal hydrolase 37; ubiquitin thioesterase 37; ubiquitin thiolesterase 37; ubiquitin-specific-processing protease 37", "tax_id": 9913, "disease": "", "pathway": " (bta:407168); (R-BTA-5689880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response. Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1. Also plays an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability. Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM. Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM. Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI. Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination., [UniProtKB, UniProtKB]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0051301 cell division;GO:0031647 regulation of protein stability;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N5V1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04973-1", "uniprot_id": [ { "id": "CLCA_BOVIN", "url": "https://www.uniprot.org/uniprot/P04973", "type": "external" } ], "mass": 26723.0, "length": 243, "protein_name": "Clathrin light chain A", "gene_name": "CLTA", "organism": "Bovine", "refseq_name": "clathrin light chain A", "refseq_ac": [ { "id": "NP_776447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776447", "type": "external" } ], "gene_names_uniprotkb": "CLTA", "gene_names_refseq": "CLTA2; CLTA", "protein_names_uniprotkb": "Clathrin light chain A; Lca", "protein_names_refseq": "clathrin light chain A; clathrin, light chain (Lca); clathrin, light chain A2; clathrin, light polypeptide (Lca); lca", "tax_id": 9913, "disease": "", "pathway": " (bta:281078); (R-BTA-177504); (R-BTA-190873); (R-BTA-196025); (R-BTA-2132295); (R-BTA-432720); (R-BTA-432722); (R-BTA-437239); (R-BTA-5099900); (R-BTA-5140745); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-8866427); (R-BTA-8964038)", "pathway_count": 14, "publication_count": 5, "publication_id_list": "12426379;17555534;20033059;2434865;3821891", "class_list": "", "function": "Based on circular dichroism data, mapping and mutagenesis, bovine LCa and LCb were represented as alpha-helices, aligned along the heavy chain. A structural model of the interaction was generated with new implications for LC control of clathrin assembly., [RefSeq, PubMed]; Binding of light chain increases the amount of detergent needed to induce detrimerization, suggesting light chains reinforced hub trimers., [RefSeq, PubMed]; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (By similarity)., [UniProtKB, UniProtKB]; Structure of clathrin coat with bound Hsc70 and auxilin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q17QD2", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005768 endosome;GO:0005819 spindle;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0051301 cell division;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P04973-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38409-1", "uniprot_id": [ { "id": "GNA11_BOVIN", "url": "https://www.uniprot.org/uniprot/P38409", "type": "external" } ], "mass": 42070.0, "length": 359, "protein_name": "Guanine nucleotide-binding protein subunit alpha-11", "gene_name": "GNA11", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein subunit alpha-11", "refseq_ac": [ { "id": "NP_776747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776747", "type": "external" } ], "gene_names_uniprotkb": "GNA11", "gene_names_refseq": "GNA11; HG1K", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha-11; G alpha-11; G protein subunit GL2 alpha; G protein subunit alpha-11", "protein_names_refseq": "G-protein subunit GL2 alpha; g alpha-11; guanine nucleotide-binding protein subunit alpha-11; heterotrimeric guanine nucleotide-binding protein 1K", "tax_id": 9913, "disease": "", "pathway": " (bta:281788); (R-BTA-112043); (R-BTA-202040); (R-BTA-399997); (R-BTA-416476); (R-BTA-418592); (R-BTA-428930); (R-BTA-434316); (R-BTA-456926); (R-BTA-6814122); (R-BTA-9856530); (R-BTA-9860927)", "pathway_count": 12, "publication_count": 2, "publication_id_list": "12427730;1905731", "class_list": "", "function": "G protein-coupled receptor Kinase 2 reacts with this protein's signaling homology domain for binding G protein subunits, [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB, UniProtKB, UniProtKB]; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNAQ, required for heart development (By similarity). In the respiratory epithelium, transmits OXGR1-dependent signals that lead to downstream intracellular Ca(2+) release and mucocilliary clearance of airborne pathogens., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TA47", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0086100 endothelin receptor signaling pathway;GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P38409-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N264-1", "uniprot_id": [ { "id": "F1N264_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N264", "type": "external" } ], "mass": 122802.0, "length": 1127, "protein_name": "Zinc finger E-box-binding homeobox 1", "gene_name": "ZEB1", "organism": "Bovine", "refseq_name": "zinc finger E-box-binding homeobox 1", "refseq_ac": [ { "id": "NP_001193519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193519", "type": "external" } ], "gene_names_uniprotkb": "ZEB1", "gene_names_refseq": "TCF8; ZEB1; deltaEF1", "protein_names_uniprotkb": "Zinc finger E-box-binding homeobox 1; Transcription factor 8", "protein_names_refseq": "transcription factor 8 (represses interleukin 2 expression); zinc finger E-box-binding homeobox 1", "tax_id": 9913, "disease": "", "pathway": " (bta:535183); (R-BTA-9764725)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "33332227", "class_list": "", "function": "Transcription Factors ZEB1 and CREB Promote the Transcription of Bovine ABHD5 Gene., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003682 chromatin binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045666 positive regulation of neuron differentiation;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1N264-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11116-1", "uniprot_id": [ { "id": "LEG1_BOVIN", "url": "https://www.uniprot.org/uniprot/P11116", "type": "external" } ], "mass": 14744.0, "length": 135, "protein_name": "Galectin-1", "gene_name": "LGALS1", "organism": "Bovine", "refseq_name": "galectin-1", "refseq_ac": [ { "id": "NP_786976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786976", "type": "external" } ], "gene_names_uniprotkb": "LGALS1", "gene_names_refseq": "LGALS1", "protein_names_uniprotkb": "Galectin-1; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Gal-1; Galaptin; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; S-Lac lectin 1", "protein_names_refseq": "14 kDa lectin; S-Lac lectin 1; beta-galactoside-binding lectin L-14-I; gal-1; galaptin; galectin-1; lactose-binding lectin 1; lectin galactoside-binding soluble 1; lectin, galactoside-binding, soluble, 1 (galectin 1)", "tax_id": 9913, "disease": "", "pathway": " (bta:326598); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12658628;1587821;1900835;21539798;21610087;2470348;26155753;3569527;7773775;8108426", "class_list": "", "function": "Data suggest that galectin-1 and VEGFR-2 are expressed at mid-luteal stages in luteal cells of corpus luteum; galectin-1 binds directly to asparagine-linked glycans (N-glycans) on VEGFR-2 in luteal cells., [RefSeq, PubMed]; Lectin that binds beta-galactoside and a wide array of complex carbohydrates (PubMed:1900835, PubMed:7773775, PubMed:8108426). Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis., [UniProtKB, UniProtKB, UniProtKB]; The binding affinity and specificity of galectin-1 for eight different beta-galactosyl terminal disaccharides was studied using molecular-dynamics simulations., [RefSeq, PubMed]; The relative abundance of PIBF, LGALS1, LGALS3, LGALS3BP, and LGALS9 mRNA would display a differential expression pattern in the endometrium., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11945;Q54A27", "ec_number_list": [], "go_molecular_function": "GO:0043236 laminin binding;GO:0030395 lactose binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0043065 positive regulation of apoptotic process;GO:0098609 cell-cell adhesion;GO:0046598 positive regulation of viral entry into host cell;GO:0050729 positive regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P11116-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37980-1", "uniprot_id": [ { "id": "IPYR_BOVIN", "url": "https://www.uniprot.org/uniprot/P37980", "type": "external" } ], "mass": 32814.0, "length": 289, "protein_name": "Inorganic pyrophosphatase", "gene_name": "PPA1", "organism": "Bovine", "refseq_name": "inorganic pyrophosphatase", "refseq_ac": [ { "id": "NP_001068586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068586", "type": "external" } ], "gene_names_uniprotkb": "PPA1; PP", "gene_names_refseq": "PPA1; PP", "protein_names_uniprotkb": "Inorganic pyrophosphatase; 3.6.1.1; PPase; Pyrophosphate phospho-hydrolase", "protein_names_refseq": "PPase; inorganic pyrophosphatase; pyrophosphatase (inorganic) 1; pyrophosphatase 1; pyrophosphate phospho-hydrolase", "tax_id": 9913, "disease": "", "pathway": " (bta:280701); (R-BTA-379716); (R-BTA-71737)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "1339444", "class_list": "", "function": "Catalyzes the hydrolysis of inorganic diphosphate into two phosphate molecules. Has MAP kinase serine/threonine phosphatase activity toward c-Jun N-terminal kinase (JNK) and, in neuronal cells, is involved in the negative regulation of neurite growth via JNK dephosphorylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1RMH6", "ec_number_list": [ { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004427 inorganic diphosphate phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005737 cytoplasm", "go_biological_process": "GO:0006796 phosphate-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P37980-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01156-1", "uniprot_id": [ { "id": "NEUT_BOVIN", "url": "https://www.uniprot.org/uniprot/P01156", "type": "external" } ], "mass": 19843.0, "length": 170, "protein_name": "Neurotensin/neuromedin N", "gene_name": "NTS", "organism": "Bovine", "refseq_name": "neurotensin/neuromedin N precursor", "refseq_ac": [ { "id": "NP_776370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776370", "type": "external" } ], "gene_names_uniprotkb": "NTS", "gene_names_refseq": "NTS", "protein_names_uniprotkb": "Neurotensin/neuromedin N; NmN-125", "protein_names_refseq": "neurotensin/neuromedin N precursor; neurotensin/neuromedin N", "tax_id": 9913, "disease": "", "pathway": " (bta:280881); (R-BTA-375276); (R-BTA-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1112838;1167549;12401558;2832414;30662011", "class_list": "", "function": "Neurotensin acts as a key modulator of fertilization and conception in cattle., [RefSeq, PubMed]; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle., [UniProtKB, UniProtKB, UniProtKB]; The pigmented cells of the ocular ciliary epithelium release neurotensin (NT) in response to inducing agents, whereas the nonpigmented cells exhibit a significantly reduced NT secretion in response to inducers, leading to accumulation of the peptide., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCG0", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0071855 neuropeptide receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0043679 axon terminus;GO:0030133 transport vesicle", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0097746 blood vessel diameter maintenance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P01156-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97764-1", "uniprot_id": [ { "id": "QOR_BOVIN", "url": "https://www.uniprot.org/uniprot/O97764", "type": "external" } ], "mass": 35383.0, "length": 330, "protein_name": "Zeta-crystallin", "gene_name": "CRYZ", "organism": "Bovine", "refseq_name": "zeta-crystallin", "refseq_ac": [ { "id": "NP_776450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776450", "type": "external" } ], "gene_names_uniprotkb": "CRYZ", "gene_names_refseq": "CRYZ", "protein_names_uniprotkb": "Zeta-crystallin; 1.6.5.5; NADPH:quinone reductase; Quinone oxidoreductase", "protein_names_refseq": "NADPH:quinone reductase; crystallin, zeta (quinone reductase); quinone oxidoreductase; zeta-crystallin", "tax_id": 9913, "disease": "", "pathway": " (bta:281093)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9154917", "class_list": "", "function": "Multifunctional crystallin endowed with unrelated mRNA stabilization and enzymatic oxidoreductase activities. Binds (AU)-rich elements (ARE) in the 3'-UTR of target mRNA to enhance their stability. Upon metabolic acidosis, stabilizes the mRNA encoding SLC12A1 a cotransporter involved in transepithelial NH4(+) reabsorption in the medullary thick ascending limb in kidney. In response to acidosis, also participates to the adaptive increase in renal ammoniagenesis by stabilizing the mRNAs of enzymes involved in glutamine catabolism. By the same mechanism, it also regulates the expression of the antiapoptotic protein BCL2. Beside its mRNA stabilization activity, also catalyzes the reduction of orthoquinones such as 1,2-naphthoquinone or 9,10-phenanthrenequinone in the presence of NADPH in vitro and could be involved in the detoxification of xenobiotics and protection against oxidative stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VCY2", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003960 quinone reductase (NADPH) activity;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0048255 mRNA stabilization;GO:0051289 protein homotetramerization;GO:0042178 xenobiotic catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O97764-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MUR2-1", "uniprot_id": [ { "id": "F1MUR2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MUR2", "type": "external" } ], "mass": 173927.0, "length": 1539, "protein_name": "[histone H3]-trimethyl-L-lysine(4) demethylase", "gene_name": "KDM5B", "organism": "Bovine", "refseq_name": "lysine-specific demethylase 5B isoform X1", "refseq_ac": [ { "id": "XP_024832345", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832345", "type": "external" } ], "gene_names_uniprotkb": "KDM5B", "gene_names_refseq": "KDM5B", "protein_names_uniprotkb": "[histone H3]-trimethyl-L-lysine(4) demethylase; 1.14.11.67", "protein_names_refseq": "lysine-specific demethylase 5B isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:540633); (R-BTA-3214842); (R-BTA-8866911)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.67", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.67", "type": "external" } ], "go_molecular_function": "GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus;GO:0000785 chromatin;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0048511 rhythmic process;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MUR2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E5M5-1", "uniprot_id": [ { "id": "G5E5M5_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E5M5", "type": "external" } ], "mass": 25659.0, "length": 230, "protein_name": "Membrane-associated progesterone receptor component 1", "gene_name": "PGRMC1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PGRMC1", "gene_names_refseq": "", "protein_names_uniprotkb": "Membrane-associated progesterone receptor component 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6798695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005496 steroid binding;GO:0042803 protein homodimerization activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005741 mitochondrial outer membrane;GO:0030868 smooth endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:1903078 positive regulation of protein localization to plasma membrane;GO:0006783 heme biosynthetic process;GO:0140077 positive regulation of lipoprotein transport;GO:1903537 meiotic cell cycle process involved in oocyte maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E5M5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MWD3-1", "uniprot_id": [ { "id": "F1MWD3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MWD3", "type": "external" } ], "mass": 59601.0, "length": 541, "protein_name": "T-complex protein 1 subunit epsilon", "gene_name": "CCT5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CCT5", "gene_names_refseq": "", "protein_names_uniprotkb": "T-complex protein 1 subunit epsilon; CCT-epsilon", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-390471); (R-BTA-5620922); (R-BTA-6814122)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23478063;39743588", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone;GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005832 chaperonin-containing T-complex;GO:0005874 microtubule;GO:0044297 cell body", "go_biological_process": "GO:0009615 response to virus;GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1MWD3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6QV99-1", "uniprot_id": [ { "id": "ATAD1_BOVIN", "url": "https://www.uniprot.org/uniprot/F6QV99", "type": "external" } ], "mass": 40774.0, "length": 361, "protein_name": "Outer mitochondrial transmembrane helix translocase", "gene_name": "ATAD1", "organism": "Bovine", "refseq_name": "outer mitochondrial transmembrane helix translocase", "refseq_ac": [ { "id": "NP_001192510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192510", "type": "external" } ], "gene_names_uniprotkb": "ATAD1", "gene_names_refseq": "ATAD1; Thorase", "protein_names_uniprotkb": "Outer mitochondrial transmembrane helix translocase; 7.4.2.-; ATPase family AAA domain-containing protein 1; Thorase", "protein_names_refseq": "ATPase family AAA domain-containing protein 1; outer mitochondrial transmembrane helix translocase", "tax_id": 9913, "disease": "", "pathway": " (bta:506045); (R-BTA-9603798)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7MB55", "ec_number_list": [ { "id": "7.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140567 membrane protein dislocase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0045211 postsynaptic membrane;GO:0098978 glutamatergic synapse", "go_biological_process": "GO:0007612 learning;GO:0007613 memory;GO:0051967 negative regulation of synaptic transmission, glutamatergic;GO:0002092 positive regulation of receptor internalization;GO:0140570 extraction of mislocalized protein from mitochondrial outer membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F6QV99-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N4F6-1", "uniprot_id": [ { "id": "F1N4F6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N4F6", "type": "external" } ], "mass": 86412.0, "length": 763, "protein_name": "Thyrotropin receptor", "gene_name": "TSHR", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TSHR", "gene_names_refseq": "", "protein_names_uniprotkb": "Thyrotropin receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-375281); (R-BTA-418555)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS). Additionally, plays a central role in controlling thyroid cell metabolism., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004996 thyroid-stimulating hormone receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0009755 hormone-mediated signaling pathway;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N4F6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41520-1", "uniprot_id": [ { "id": "CCKN_BOVIN", "url": "https://www.uniprot.org/uniprot/P41520", "type": "external" } ], "mass": 12835.0, "length": 115, "protein_name": "Cholecystokinin", "gene_name": "CCK", "organism": "Bovine", "refseq_name": "cholecystokinin precursor", "refseq_ac": [ { "id": "NP_001040068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040068", "type": "external" } ], "gene_names_uniprotkb": "CCK", "gene_names_refseq": "CCK", "protein_names_uniprotkb": "Cholecystokinin; (1-49)-CCK58; CCK", "protein_names_refseq": "cholecystokinin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:617510); (R-BTA-375276); (R-BTA-416476)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15075451;2217909;4011954", "class_list": "", "function": "This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion., [UniProtKB, UniProtKB]; This review explores the role of luminal cholecystokinin on the regulation of exocrine pancreatic secretion in author's studies of newborn calves. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29RG8", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0051428 peptide hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030424 axon;GO:0005576 extracellular region", "go_biological_process": "GO:0007409 axonogenesis;GO:0001764 neuron migration;GO:0032094 response to food;GO:0042755 eating behavior;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P41520-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N3A5-1", "uniprot_id": [ { "id": "F1N3A5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N3A5", "type": "external" } ], "mass": 151725.0, "length": 1407, "protein_name": "Protein crumbs homolog 1", "gene_name": "CRB1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CRB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein crumbs homolog 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005912 adherens junction;GO:0016324 apical plasma membrane;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007163 establishment or maintenance of cell polarity;GO:0060042 retina morphogenesis in camera-type eye;GO:0007399 nervous system development;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N3A5-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04557-1", "uniprot_id": [ { "id": "SFP3_BOVIN", "url": "https://www.uniprot.org/uniprot/P04557", "type": "external" } ], "mass": 16140.0, "length": 140, "protein_name": "Seminal plasma protein A3", "gene_name": "BSP3", "organism": "Bovine", "refseq_name": "seminal plasma protein A3 precursor", "refseq_ac": [ { "id": "NP_777265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777265", "type": "external" } ], "gene_names_uniprotkb": "BSP3", "gene_names_refseq": "BSP3; SVS8", "protein_names_uniprotkb": "Seminal plasma protein A3; BSP-A3", "protein_names_refseq": "BSP-A3; seminal plasma protein A3 precursor; seminal plasma protein A3; seminal vesicle secretion 8", "tax_id": 9913, "disease": "", "pathway": " (bta:317695)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10377061;12354160;16790686;23740081;3606570", "class_list": "", "function": "BSP-A3 plays a crucial role in fertilization by maintaining sperm motility during storage., [RefSeq, PubMed]; Data suggest that binding of BSP1, BSP3, and BSP5 is increased on surface of bull sperm following cryopreservation; binder of sperm proteins appear to play roles in formation of oviductal sperm storage reservoir and in sperm capacitation. Publication Status: Online-Only, [RefSeq, PubMed]; Genome mapping of the bovine seminal plasma A3 gene (BSPA3 )., [RefSeq, PubMed]; The BSP-A proteins from seminal plasma exhibit both simulatory and inhibitory actions on the release of pituitary gonadotropins. The exact function of these proteins is not known., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9TUE5", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0033700 phospholipid efflux;GO:0007338 single fertilization;GO:0048240 sperm capacitation;GO:1902492 positive regulation of sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P04557-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6QHI8-1", "uniprot_id": [ { "id": "F6QHI8_BOVIN", "url": "https://www.uniprot.org/uniprot/F6QHI8", "type": "external" } ], "mass": 86903.0, "length": 781, "protein_name": "Nucleolar RNA helicase 2", "gene_name": "DDX21", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DDX21", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleolar RNA helicase 2; 3.6.4.13; DEAD box protein 21; Gu-alpha; Nucleolar RNA helicase Gu; Nucleolar RNA helicase II; RH II/Gu", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5250924); (R-BTA-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006364 rRNA processing;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6QHI8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1M7-1", "uniprot_id": [ { "id": "F1N1M7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1M7", "type": "external" } ], "mass": 74455.0, "length": 658, "protein_name": "Carnitine O-palmitoyltransferase 2, mitochondrial", "gene_name": "CPT2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CPT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Carnitine O-palmitoyltransferase 2, mitochondrial; 2.3.1.21; Carnitine palmitoyltransferase II", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-200425); (R-BTA-77305)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" } ], "go_molecular_function": "GO:0004095 carnitine O-palmitoyltransferase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0015909 long-chain fatty acid transport;GO:0001676 long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006853 carnitine shuttle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N1M7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F2Z4H3-1", "uniprot_id": [ { "id": "RPAB3_BOVIN", "url": "https://www.uniprot.org/uniprot/F2Z4H3", "type": "external" } ], "mass": 17143.0, "length": 150, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC3", "gene_name": "POLR2H", "organism": "Bovine", "refseq_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC3", "refseq_ac": [ { "id": "NP_001178994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178994", "type": "external" } ], "gene_names_uniprotkb": "POLR2H", "gene_names_refseq": "POLR2H", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC3", "protein_names_refseq": "DNA-directed RNA polymerases I, II, and III subunit RPABC3; RNA polymerase II subunit H; polymerase (RNA) II (DNA directed) polypeptide H", "tax_id": 9913, "disease": "", "pathway": " (bta:505599); (R-BTA-112382); (R-BTA-113418); (R-BTA-5250924); (R-BTA-5578749); (R-BTA-674695); (R-BTA-6781823); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-6796648); (R-BTA-6803529); (R-BTA-6807505); (R-BTA-72086); (R-BTA-72163); (R-BTA-72165); (R-BTA-72203); (R-BTA-73762); (R-BTA-73772); (R-BTA-73776); (R-BTA-73779); (R-BTA-73863); (R-BTA-75953); (R-BTA-75955); (R-BTA-76042); (R-BTA-76061); (R-BTA-76066); (R-BTA-76071); (R-BTA-77075); (R-BTA-9018519); (R-BTA-9770562)", "pathway_count": 30, "publication_count": 3, "publication_id_list": "16769904;26789250;28892040", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003697 single-stranded DNA binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0032993 protein-DNA complex;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006362 transcription elongation by RNA polymerase I;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F2Z4H3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46510-1", "uniprot_id": [ { "id": "EPB42_BOVIN", "url": "https://www.uniprot.org/uniprot/O46510", "type": "external" } ], "mass": 76617.0, "length": 687, "protein_name": "Protein 4.2", "gene_name": "EPB42", "organism": "Bovine", "refseq_name": "protein 4.2", "refseq_ac": [ { "id": "NP_776737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776737", "type": "external" } ], "gene_names_uniprotkb": "EPB42; BEP42", "gene_names_refseq": "EPB42", "protein_names_uniprotkb": "Protein 4.2; Erythrocyte membrane protein band 4.2; Erythrocyte protein 4.2; P4.2", "protein_names_refseq": "P4.2; erythrocyte protein 4.2; protein 4.2", "tax_id": 9913, "disease": "", "pathway": " (bta:281754)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9576866", "class_list": "", "function": "Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O46509", "ec_number_list": [], "go_molecular_function": "GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0170014 ankyrin-1 complex", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0008360 regulation of cell shape;GO:0018149 peptide cross-linking", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O46510-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MX80-1", "uniprot_id": [ { "id": "F1MX80_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MX80", "type": "external" } ], "mass": 64490.0, "length": 580, "protein_name": "mRNA m(6)A methyltransferase", "gene_name": "METTL3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "METTL3", "gene_names_refseq": "", "protein_names_uniprotkb": "mRNA m(6)A methyltransferase; 2.1.1.348", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-72203)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.1.1.348", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348", "type": "external" }, { "id": "1.13.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.27", "type": "external" } ], "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003729 mRNA binding;GO:0046982 protein heterodimerization activity;GO:1990931 mRNA N6-methyladenosine dioxygenase activity;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0001510 RNA methylation;GO:1903679 positive regulation of cap-independent translational initiation;GO:0016556 mRNA modification;GO:0006974 DNA damage response;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MX80-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N381-1", "uniprot_id": [ { "id": "F1N381_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N381", "type": "external" } ], "mass": 110605.0, "length": 999, "protein_name": "Tyrosine-protein kinase Mer", "gene_name": "MERTK", "organism": "Bovine", "refseq_name": "tyrosine-protein kinase Mer precursor", "refseq_ac": [ { "id": "NP_001178953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178953", "type": "external" } ], "gene_names_uniprotkb": "MERTK", "gene_names_refseq": "MERTK", "protein_names_uniprotkb": "Tyrosine-protein kinase Mer; 2.7.10.1; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK", "protein_names_refseq": "c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:504429); (R-BTA-202733)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0043235 receptor complex", "go_biological_process": "GO:0006909 phagocytosis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0050766 positive regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N381-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21450-1", "uniprot_id": [ { "id": "EDNRA_BOVIN", "url": "https://www.uniprot.org/uniprot/P21450", "type": "external" } ], "mass": 48515.0, "length": 427, "protein_name": "Endothelin-1 receptor", "gene_name": "EDNRA", "organism": "Bovine", "refseq_name": "endothelin-1 receptor precursor", "refseq_ac": [ { "id": "NP_776733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776733", "type": "external" } ], "gene_names_uniprotkb": "EDNRA", "gene_names_refseq": "EDNRA", "protein_names_uniprotkb": "Endothelin-1 receptor; ET-AR; ET-A; Endothelin receptor type A", "protein_names_refseq": "ET-AR; ET-A; endothelin A receptor; endothelin-1 receptor precursor; endothelin-1 receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281749); (R-BTA-375276); (R-BTA-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12788101;15838292;16962346;2175396;22921266;25370848", "class_list": "", "function": "Brain microvessel endothelin type A receptors are coupled to ceramide production., [RefSeq, PubMed]; Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2, EDN3) and EDN-converting enzymes (ECE1, ECE2) are expressed in epithelial cells; EDN receptors (EDNRA, EDNRB) are present in smooth-muscle. Expression of EDN1, EDN2, and ECE2 is highest on day of ovulation. EDN/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows., [RefSeq, PubMed]; Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy., [RefSeq, PubMed]; ET receptors in pigment cells of vertebrate species were identified by RT-PCR assays, and the differential expression of the various subtypes in each species was compared by quantitative PCR., [RefSeq, PubMed]; Elevated local expression of ET-1 and Ednra/Ednrb during the peri-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport., [RefSeq, PubMed]; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A3KMY5;A5PK08", "ec_number_list": [], "go_molecular_function": "GO:0004962 endothelin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030878 thyroid gland development;GO:1904888 cranial skeletal system development;GO:0048484 enteric nervous system development;GO:0086100 endothelin receptor signaling pathway;GO:0061028 establishment of endothelial barrier", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P21450-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01217-1", "uniprot_id": [ { "id": "GLHA_BOVIN", "url": "https://www.uniprot.org/uniprot/P01217", "type": "external" } ], "mass": 13616.0, "length": 120, "protein_name": "Glycoprotein hormones alpha chain", "gene_name": "CGA", "organism": "Bovine", "refseq_name": "glycoprotein hormones alpha chain precursor", "refseq_ac": [ { "id": "NP_776326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776326", "type": "external" } ], "gene_names_uniprotkb": "CGA", "gene_names_refseq": "CGA; GPA1", "protein_names_uniprotkb": "Glycoprotein hormones alpha chain; Anterior pituitary glycoprotein hormones common subunit alpha; FSH-alpha; Follicle-stimulating hormone alpha chain; Follitropin alpha chain; LSH-alpha; Luteinizing hormone alpha chain; Lutropin alpha chain; TSH-alpha; Thyroid-stimulating hormone alpha chain; Thyrotropin alpha chain", "protein_names_refseq": "FSH-alpha; LSH-alpha; TSH-alpha; anterior pituitary glycoprotein hormones common subunit alpha; chorionic gonadotropin, alpha chain; follicle-stimulating hormone alpha chain; follitropin alpha chain; glycoprotein hormone alpha subunit; glycoprotein hormones alpha chain precursor; glycoprotein hormones alpha chain; luteinizing hormone alpha chain; lutropin alpha chain; thyroid-stimulating hormone alpha chain; thyrotropin alpha chain", "tax_id": 9913, "disease": "", "pathway": " (bta:280749); (R-BTA-193048); (R-BTA-193993); (R-BTA-209822); (R-BTA-209968); (R-BTA-375281); (R-BTA-418555); (R-BTA-8866910); (R-BTA-975578)", "pathway_count": 9, "publication_count": 12, "publication_id_list": "11502219;11520036;22460152;24444496;2946684;4854483;5101174;5101175;5107231;6187740;6314263;6688736", "class_list": "", "function": "Neurotrophin 4 may have a role in regulating the function of bovine oviducts by interacting with gonadotrophins., [RefSeq, PubMed]; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results demonstrate that elevated TSH can promote endothelial dysfunction by altering gene expression in human umbilical vein endothelial cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 78, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016913 follicle-stimulating hormone activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016914 follicle-stimulating hormone complex;GO:0005576 extracellular region", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0010469 regulation of signaling receptor activity;GO:0010893 positive regulation of steroid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 9.4, "record_id": "P01217-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXW0-1", "uniprot_id": [ { "id": "F1MXW0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXW0", "type": "external" } ], "mass": 76475.0, "length": 677, "protein_name": "Polyunsaturated fatty acid lipoxygenase ALOX15", "gene_name": "ALOX15B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ALOX15B", "gene_names_refseq": "", "protein_names_uniprotkb": "Polyunsaturated fatty acid lipoxygenase ALOX15; 1.13.11.12; 12/15-lipoxygenase; Arachidonate 12-lipoxygenase, leukocyte-type; Arachidonate 15-lipoxygenase; Arachidonate omega-6 lipoxygenase; Erythroid cell-specific 15-lipoxygenase; Hepoxilin A3 synthase Alox15; Linoleate 13S-lipoxygenase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2142770)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "1.13.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.31", "type": "external" }, { "id": "1.13.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.33", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:0005509 calcium ion binding;GO:0008289 lipid binding;GO:0016165 linoleate 13S-lipoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0034440 lipid oxidation;GO:0019369 arachidonate metabolic process;GO:0071926 endocannabinoid signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0032722 positive regulation of chemokine production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXW0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N405-1", "uniprot_id": [ { "id": "F1N405_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N405", "type": "external" } ], "mass": 133667.0, "length": 1230, "protein_name": "Reticulon", "gene_name": "RTN4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RTN4", "gene_names_refseq": "", "protein_names_uniprotkb": "Reticulon", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-193634)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0098978 glutamatergic synapse;GO:0005635 nuclear envelope;GO:0014069 postsynaptic density;GO:0043025 neuronal cell body", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1902430 negative regulation of amyloid-beta formation;GO:0007420 brain development;GO:0050821 protein stabilization;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N405-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MU35-1", "uniprot_id": [ { "id": "F1MU35_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MU35", "type": "external" } ], "mass": 81501.0, "length": 725, "protein_name": "Protein kinase C", "gene_name": "PRKCG", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PRKCG", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein kinase C; 2.7.11.13", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:282002)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity;GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system;GO:0099524 postsynaptic cytosol", "go_biological_process": "GO:0048511 rhythmic process;GO:0032425 positive regulation of mismatch repair;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0031397 negative regulation of protein ubiquitination;GO:0042177 negative regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MU35-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X812-1", "uniprot_id": [ { "id": "G3X812_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X812", "type": "external" } ], "mass": 208335.0, "length": 1992, "protein_name": "Neurogenic locus notch homolog protein 4", "gene_name": "NOTCH4", "organism": "Bovine", "refseq_name": "neurogenic locus notch homolog protein 4 isoform X1", "refseq_ac": [ { "id": "XP_024839432", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839432", "type": "external" } ], "gene_names_uniprotkb": "NOTCH4", "gene_names_refseq": "NOTCH4", "protein_names_uniprotkb": "Neurogenic locus notch homolog protein 4", "protein_names_refseq": "neurogenic locus notch homolog protein 4 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:536128); (R-BTA-1912420); (R-BTA-350054); (R-BTA-9013700)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0038023 signaling receptor activity;GO:0003713 transcription coactivator activity;GO:0005112 Notch binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription;GO:0045595 regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3X812-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MVC0-1", "uniprot_id": [ { "id": "F1MVC0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MVC0", "type": "external" } ], "mass": 243038.0, "length": 2225, "protein_name": "Multifunctional protein CAD", "gene_name": "CAD", "organism": "Bovine", "refseq_name": "multifunctional protein CAD", "refseq_ac": [ { "id": "NP_001178322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178322", "type": "external" } ], "gene_names_uniprotkb": "CAD", "gene_names_refseq": "CAD", "protein_names_uniprotkb": "Multifunctional protein CAD; 2.1.3.2; 3.5.1.2; 3.5.2.3; 6.3.4.16; 6.3.5.5; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase", "protein_names_refseq": "multifunctional protein CAD", "tax_id": 9913, "disease": "", "pathway": " (bta:504261); (R-BTA-500753)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "30573663;31056337", "class_list": "", "function": "Missense mutation in CAD (g.72399397T>C; p.Tyr452Cys) showed a marked reduction in conception rates., [RefSeq, PubMed]; Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.2", "type": "external" }, { "id": "6.3.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.16", "type": "external" }, { "id": "6.3.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.5", "type": "external" }, { "id": "2.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.2", "type": "external" }, { "id": "3.5.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.3", "type": "external" } ], "go_molecular_function": "GO:0004087 carbamoyl-phosphate synthase (ammonia) activity;GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0004151 dihydroorotase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016363 nuclear matrix;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006520 amino acid metabolic process;GO:0006541 glutamine metabolic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205 'de novo' UMP biosynthetic process;GO:0006225 UDP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1MVC0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35350-1", "uniprot_id": [ { "id": "ACKR4_BOVIN", "url": "https://www.uniprot.org/uniprot/P35350", "type": "external" } ], "mass": 40008.0, "length": 350, "protein_name": "Atypical chemokine receptor 4", "gene_name": "ACKR4", "organism": "Bovine", "refseq_name": "atypical chemokine receptor 4", "refseq_ac": [ { "id": "NP_776690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776690", "type": "external" } ], "gene_names_uniprotkb": "ACKR4; CCR11; CCRL1", "gene_names_refseq": "ACKR4; CCRL1", "protein_names_uniprotkb": "Atypical chemokine receptor 4; C-C CKR-11; C-C chemokine receptor type 11; CC chemokine receptor-like 1; CC-CKR-11; CCR-11; Protein PPR1; Putative gustatory receptor type B", "protein_names_refseq": "C-C CKR-11; C-C chemokine receptor type 11; CC chemokine receptor-like 1; CC-CKR-11; CCR-11; atypical chemokine receptor 4; chemokine (C-C motif) receptor-like 1; putative gustatory receptor type B", "tax_id": 9913, "disease": "", "pathway": " (bta:281672); (R-BTA-380108)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8392843", "class_list": "", "function": "Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A5PJM3", "ec_number_list": [], "go_molecular_function": "GO:0004950 chemokine receptor activity;GO:0005044 scavenger receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0019956 chemokine binding", "go_cellular_component": "GO:0005769 early endosome;GO:0055037 recycling endosome;GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis;GO:0006935 chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35350-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MVW3-1", "uniprot_id": [ { "id": "F1MVW3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MVW3", "type": "external" } ], "mass": 85584.0, "length": 767, "protein_name": "Integrin beta", "gene_name": "ITGB8", "organism": "Bovine", "refseq_name": "integrin beta-8 precursor", "refseq_ac": [ { "id": "NP_001179804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179804", "type": "external" } ], "gene_names_uniprotkb": "ITGB8", "gene_names_refseq": "ITGB8", "protein_names_uniprotkb": "Integrin beta", "protein_names_refseq": "integrin beta-8 precursor; integrin, beta 8", "tax_id": 9913, "disease": "", "pathway": " (bta:536286); (R-BTA-2129379); (R-BTA-216083); (R-BTA-2173789)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Required during vasculogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:1990430 extracellular matrix protein binding;GO:0005178 integrin binding;GO:0015026 coreceptor activity", "go_cellular_component": "GO:0034686 integrin alphav-beta8 complex;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0008305 integrin complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0030154 cell differentiation;GO:0001570 vasculogenesis;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MVW3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MZJ2-1", "uniprot_id": [ { "id": "G3MZJ2_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MZJ2", "type": "external" } ], "mass": 113273.0, "length": 1007, "protein_name": "Glutamate receptor", "gene_name": "GRID2", "organism": "Bovine", "refseq_name": "glutamate receptor ionotropic, delta-2", "refseq_ac": [ { "id": "XP_015327031", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327031", "type": "external" } ], "gene_names_uniprotkb": "GRID2", "gene_names_refseq": "GRID2", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, delta-2", "tax_id": 9913, "disease": "", "pathway": " (bta:536367)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex. In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine. However, recent research disputes this ligand-gated cation channel activity. Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells., [UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity;GO:0030165 PDZ domain binding;GO:0097110 scaffold protein binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0032281 AMPA glutamate receptor complex", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0035249 synaptic transmission, glutamatergic;GO:0051965 positive regulation of synapse assembly;GO:0050804 modulation of chemical synaptic transmission;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MZJ2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21839-1", "uniprot_id": [ { "id": "ODBB_BOVIN", "url": "https://www.uniprot.org/uniprot/P21839", "type": "external" } ], "mass": 42935.0, "length": 392, "protein_name": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial", "gene_name": "BCKDHB", "organism": "Bovine", "refseq_name": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776932", "type": "external" } ], "gene_names_uniprotkb": "BCKDHB", "gene_names_refseq": "BCKDHB", "protein_names_uniprotkb": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; 1.2.4.4; BCKDE1B; BCKDH E1-beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain", "protein_names_refseq": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor; 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; BCKDE1B; BCKDH E1-beta; branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease); branched-chain alpha-keto acid dehydrogenase E1 component beta chain", "tax_id": 9913, "disease": "", "pathway": " (bta:282150); (R-BTA-70895); (R-BTA-9859138)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1730724;2322554;283398;447664;5656388", "class_list": "", "function": "Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148F4;Q28047", "ec_number_list": [ { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.2.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003863 branched-chain 2-oxo acid dehydrogenase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0160157 branched-chain alpha-ketoacid dehydrogenase complex;GO:0005739 mitochondrion", "go_biological_process": "GO:0007584 response to nutrient;GO:0009083 branched-chain amino acid catabolic process;GO:0120552 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P21839-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N712-1", "uniprot_id": [ { "id": "F1N712_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N712", "type": "external" } ], "mass": 96545.0, "length": 914, "protein_name": "Progesterone receptor", "gene_name": "PGR", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PGR", "gene_names_refseq": "", "protein_names_uniprotkb": "Progesterone receptor; Nuclear receptor subfamily 3 group C member 3; PR", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3371497); (R-BTA-383280); (R-BTA-4090294); (R-BTA-9018519)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Steroid hormone receptor involved in the regulation of eukaryotic gene expression which affects cellular proliferation and differentiation in target tissues., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0005496 steroid binding;GO:0043565 sequence-specific DNA binding;GO:0034056 estrogen response element binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0051457 maintenance of protein location in nucleus;GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N712-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G8JL05-1", "uniprot_id": [ { "id": "G8JL05_BOVIN", "url": "https://www.uniprot.org/uniprot/G8JL05", "type": "external" } ], "mass": 55804.0, "length": 485, "protein_name": "Lysophospholipid acyltransferase 5", "gene_name": "LPCAT3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LPCAT3", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysophospholipid acyltransferase 5; 2.3.1.23; 2.3.1.n6", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1482788); (R-BTA-1482801); (R-BTA-1482839)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" } ], "go_molecular_function": "GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0071617 lysophospholipid acyltransferase activity;GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity;GO:0106263 1-acylglycerophosphoserine O-acyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0008654 phospholipid biosynthetic process;GO:0090158 endoplasmic reticulum membrane organization;GO:0045540 regulation of cholesterol biosynthetic process;GO:0050728 negative regulation of inflammatory response;GO:0006656 phosphatidylcholine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G8JL05-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H9KUV0-1", "uniprot_id": [ { "id": "H9KUV0_BOVIN", "url": "https://www.uniprot.org/uniprot/H9KUV0", "type": "external" } ], "mass": 38065.0, "length": 358, "protein_name": "Doublesex and mab-3 related transcription factor 1", "gene_name": "DMRT1", "organism": "Bovine", "refseq_name": "doublesex and mab-3 related transcription factor 1 isoform X1", "refseq_ac": [ { "id": "XP_024851713", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851713", "type": "external" } ], "gene_names_uniprotkb": "DMRT1", "gene_names_refseq": "DMRT1", "protein_names_uniprotkb": "Doublesex and mab-3 related transcription factor 1", "protein_names_refseq": "doublesex and mab-3 related transcription factor 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0046661 male sex differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "H9KUV0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46521-1", "uniprot_id": [ { "id": "CY24A_BOVIN", "url": "https://www.uniprot.org/uniprot/O46521", "type": "external" } ], "mass": 20496.0, "length": 191, "protein_name": "Cytochrome b-245 light chain", "gene_name": "CYBA", "organism": "Bovine", "refseq_name": "cytochrome b-245 light chain", "refseq_ac": [ { "id": "NP_776459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776459", "type": "external" } ], "gene_names_uniprotkb": "CYBA", "gene_names_refseq": "CYBA", "protein_names_uniprotkb": "Cytochrome b-245 light chain; Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phox", "protein_names_refseq": "cytochrome b(558) alpha chain; cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; cytochrome b558 subunit alpha; neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22-phox; p22phox; superoxide-generating NADPH oxidase light chain subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:281111); (R-BTA-1222556); (R-BTA-1236973); (R-BTA-3299685); (R-BTA-4420097); (R-BTA-5668599); (R-BTA-6798695); (R-BTA-9013404); (R-BTA-9013423)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "9665285", "class_list": "", "function": "Subunit of NADPH oxidase complexes that is required for the NADPH oxidase activity that generates, in various cell types, superoxide from molecular oxygen utilizing NADPH as an electron donor. Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. Aassociates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PK68", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0017124 SH3 domain binding;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0020037 heme binding", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0032755 positive regulation of interleukin-6 production;GO:0050766 positive regulation of phagocytosis;GO:0032760 positive regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O46521-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30931-1", "uniprot_id": [ { "id": "TF_BOVIN", "url": "https://www.uniprot.org/uniprot/P30931", "type": "external" } ], "mass": 32475.0, "length": 292, "protein_name": "Tissue factor", "gene_name": "F3", "organism": "Bovine", "refseq_name": "tissue factor precursor", "refseq_ac": [ { "id": "NP_776303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776303", "type": "external" } ], "gene_names_uniprotkb": "F3", "gene_names_refseq": "F3; TF", "protein_names_uniprotkb": "Tissue factor; Coagulation factor III; TF", "protein_names_refseq": "coagulation factor III (thromboplastin, tissue factor); thromboplastin; tissue factor precursor; tissue factor", "tax_id": 9913, "disease": "", "pathway": " (bta:280686); (R-BTA-9769735); (R-BTA-9769739)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "1764065", "class_list": "", "function": "Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q08DD5", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0004896 cytokine receptor activity;GO:0002020 protease binding;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007596 blood coagulation;GO:0045766 positive regulation of angiogenesis;GO:0001938 positive regulation of endothelial cell proliferation;GO:0032008 positive regulation of TOR signaling;GO:2000353 positive regulation of endothelial cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P30931-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77628-1", "uniprot_id": [ { "id": "FOS_BOVIN", "url": "https://www.uniprot.org/uniprot/O77628", "type": "external" } ], "mass": 40737.0, "length": 380, "protein_name": "Protein c-Fos", "gene_name": "FOS", "organism": "Bovine", "refseq_name": "protein c-Fos", "refseq_ac": [ { "id": "NP_877587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877587", "type": "external" } ], "gene_names_uniprotkb": "FOS", "gene_names_refseq": "FOS", "protein_names_uniprotkb": "Protein c-Fos; Cellular oncogene fos; Transcription factor AP-1 subunit c-Fos", "protein_names_refseq": "cellular oncogene fos; protein c-Fos; proto-oncogene c-Fos; proto-oncogene protein c-fos; transcription factor AP-1 subunit c-Fos", "tax_id": 9913, "disease": "", "pathway": " (bta:280795); (R-BTA-2559580); (R-BTA-2871796); (R-BTA-450341); (R-BTA-9018519)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "16305752;18368600;18974265;32070024", "class_list": "", "function": "C-Fos/c-Jun complex binds to the proximal StAR promoter in glomerulosa cells, thus activating StAR gene expression and acute aldosterone biosynthesis., [RefSeq, PubMed]; NCAPG Dynamically Coordinates the Myogenesis of Fetal Bovine Tissue by Adjusting Chromatin Accessibility. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity)., [UniProtKB]; The present data indicate that bovine dialyzable leukocyte extract can block the AP-1 DNA-binding activity and expression of several transcriptions factors in breast cancer cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1L550;Q17QM0;Q7YRP7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0006355 regulation of DNA-templated transcription;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0060395 SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O77628-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MSK4-1", "uniprot_id": [ { "id": "F1MSK4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MSK4", "type": "external" } ], "mass": 56938.0, "length": 514, "protein_name": "DNA-(apurinic or apyrimidinic site) endonuclease", "gene_name": "APEX2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "APEX2", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-(apurinic or apyrimidinic site) endonuclease; 3.1.-.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0004519 endonuclease activity;GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0001650 fibrillar center;GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MSK4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E556-1", "uniprot_id": [ { "id": "G5E556_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E556", "type": "external" } ], "mass": 293184.0, "length": 2596, "protein_name": "ATP binding cassette subfamily A member 12", "gene_name": "ABCA12", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ABCA12", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP binding cassette subfamily A member 12", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1369062)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity;GO:0005319 lipid transporter activity;GO:0034191 apolipoprotein A-I receptor binding", "go_cellular_component": "GO:0030659 cytoplasmic vesicle membrane;GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0097234 epidermal lamellar body membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0032376 positive regulation of cholesterol transport;GO:0006886 intracellular protein transport;GO:0010875 positive regulation of cholesterol efflux;GO:0033700 phospholipid efflux", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E556-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17322-1", "uniprot_id": [ { "id": "EDN1_BOVIN", "url": "https://www.uniprot.org/uniprot/P17322", "type": "external" } ], "mass": 22977.0, "length": 202, "protein_name": "Endothelin-1", "gene_name": "EDN1", "organism": "Bovine", "refseq_name": "endothelin-1 precursor", "refseq_ac": [ { "id": "NP_851353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851353", "type": "external" } ], "gene_names_uniprotkb": "EDN1", "gene_names_refseq": "EDN1", "protein_names_uniprotkb": "Endothelin-1; ET-1; PPET1; Preproendothelin-1", "protein_names_refseq": "ET-1; PPET1; endothelin-1 precursor; preproendothelin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:281137); (R-BTA-375276); (R-BTA-416476)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1592477;2198541;22921266;2362823;25370848;25399298;26781611;26910780", "class_list": "", "function": "Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2, EDN3) and EDN-converting enzymes (ECE1, ECE2) are expressed in epithelial cells; EDN receptors (EDNRA, EDNRB) are present in smooth-muscle. Expression of EDN1, EDN2, and ECE2 is highest on day of ovulation. EDN/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows., [RefSeq, PubMed]; Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy., [RefSeq, PubMed]; EDN-1 may be involved in the protection of sperm from phagocytosis by polymorphonuclear neutrophils in the bovine oviduct, supporting sperm survival until fertilization, [RefSeq, PubMed]; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G protein-coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments. NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2., [UniProtKB, UniProtKB]; Results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase-PKCalpha-p(38)MAPK and NFkappaB-MT1MMP signaling pathways along with a marked decrease in TIMP-2 expression in the cells, [RefSeq, PubMed]; We demonstrated that (i) treatment of bovine pulmonary artery smooth muscle cells with ET-1 stimulates cPLA2 activity in the cell membrane., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0C1", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0031707 endothelin A receptor binding;GO:0031708 endothelin B receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0030878 thyroid gland development;GO:0086100 endothelin receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P17322-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MY82-1", "uniprot_id": [ { "id": "F1MY82_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MY82", "type": "external" } ], "mass": 77748.0, "length": 683, "protein_name": "Protein kinase C eta type", "gene_name": "PRKCH", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PRKCH", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein kinase C eta type; 2.7.11.13; PKC-L; nPKC-eta", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-114508)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:0010744 positive regulation of macrophage derived foam cell differentiation;GO:0034351 negative regulation of glial cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MY82-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35445-1", "uniprot_id": [ { "id": "COMP_BOVIN", "url": "https://www.uniprot.org/uniprot/P35445", "type": "external" } ], "mass": 82362.0, "length": 756, "protein_name": "Cartilage oligomeric matrix protein", "gene_name": "COMP", "organism": "Bovine", "refseq_name": "cartilage oligomeric matrix protein precursor", "refseq_ac": [ { "id": "NP_001159989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159989", "type": "external" } ], "gene_names_uniprotkb": "COMP", "gene_names_refseq": "COMP", "protein_names_uniprotkb": "Cartilage oligomeric matrix protein; COMP", "protein_names_refseq": "cartilage oligomeric matrix protein precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281088); (R-BTA-216083)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12853037;1429587;15075323;17307347;17518631;17716974;21604381;31389735", "class_list": "", "function": "COMP acts as a catalyst in collagen fibrillogenesis., [RefSeq, PubMed]; COMP mRNA expression level was markedly increased by ball oscillation., [RefSeq, PubMed]; COMP mutant expression in tendon fibroblasts leads to increased apoptotic cell death irrespective of the secretory characteristics of mutant COMP, [RefSeq, PubMed]; COMP regulation of BMPR2 appears to have an important role in controlling hypoxia-elicited changes in pulmonary artery superoxide and its potential regulation of contractile phenotype proteins., [RefSeq, PubMed]; COMP synthesis is differentially regulated by TGFbeta1 in the surface and middle zones of bovine articular cartilage., [RefSeq, PubMed]; Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (By similarity). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Role for proteinases other than MMPs in the degradation of COMP in cartilage, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0043066 negative regulation of apoptotic process;GO:0051260 protein homooligomerization;GO:0006915 apoptotic process;GO:0060173 limb development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P35445-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19687-1", "uniprot_id": [ { "id": "GCYA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P19687", "type": "external" } ], "mass": 77533.0, "length": 691, "protein_name": "Guanylate cyclase soluble subunit alpha-1", "gene_name": "GUCY1A1", "organism": "Bovine", "refseq_name": "guanylate cyclase soluble subunit alpha-1", "refseq_ac": [ { "id": "NP_786972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786972", "type": "external" } ], "gene_names_uniprotkb": "GUCY1A1; GUC1A1", "gene_names_refseq": "GUCY1A1; GUCY1A3", "protein_names_uniprotkb": "Guanylate cyclase soluble subunit alpha-1; 4.6.1.2; GCS-alpha-1; Soluble guanylate cyclase large subunit", "protein_names_refseq": "GCS-alpha-1; NO-sensitive GC alpha 1 subunit; guanylate cyclase 1, soluble, alpha 3; guanylate cyclase soluble subunit alpha-1; guanylate cyclase soluble subunit alpha-3; larger subunit of soluble guanylyl cyclase; nitric oxide-sensitive guanylyl cyclase alpha 1 subunit; soluble guanylate cyclase large subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:281216); (R-BTA-445355)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15749699;1973124;22223482;33744315;9391039", "class_list": "", "function": "First 3D-Structural Data of Full-Length Guanylyl Cyclase 1 in Rod-Outer-Segment Preparations of Bovine Retina by Cross-Linking/Mass Spectrometry., [RefSeq, PubMed]; The N-terminal region of nitric oxide-sensitive guanylyl cyclase alpha 1 subunit(amino acids 61-128) is mandatory for quantitative dimerization., [RefSeq, PubMed]; We concluded that the alpha-subunit and the beta(1)(191-619) domain exert structural strains on the heme domain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0008074 guanylate cyclase complex, soluble;GO:0005737 cytoplasm", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0038060 nitric oxide-cGMP-mediated signaling;GO:0070482 response to oxygen levels;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P19687-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34979-1", "uniprot_id": [ { "id": "PE2R3_BOVIN", "url": "https://www.uniprot.org/uniprot/P34979", "type": "external" } ], "mass": 46362.0, "length": 417, "protein_name": "Prostaglandin E2 receptor EP3 subtype", "gene_name": "PTGER3", "organism": "Bovine", "refseq_name": "prostaglandin E2 receptor EP3 subtype", "refseq_ac": [ { "id": "NP_851375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851375", "type": "external" } ], "gene_names_uniprotkb": "PTGER3", "gene_names_refseq": "PTGER3", "protein_names_uniprotkb": "Prostaglandin E2 receptor EP3 subtype; PGE receptor EP3 subtype; PGE2 receptor EP3 subtype; Prostanoid EP3 receptor", "protein_names_refseq": "PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; prostaglandin E receptor 3 (subtype EP3); prostaglandin E2 receptor EP3 subtype; prostanoid EP3 receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:282330); (R-BTA-391908); (R-BTA-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8396726", "class_list": "", "function": "Receptor for prostaglandin E2 (PGE2) (PubMed:8396726). The various isoforms have identical ligand binding properties but interact with different second messenger systems: isoform EP3A couples to G(i)/G(o) proteins; isoform EP3B and isoform EP3C couple to G(s), and isoform EP3D couples to G(i), G(s) and G(p) (PubMed:8396726). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004957 prostaglandin E receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0060455 negative regulation of gastric acid secretion;GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P34979-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11456-1", "uniprot_id": [ { "id": "MPRD_BOVIN", "url": "https://www.uniprot.org/uniprot/P11456", "type": "external" } ], "mass": 31201.0, "length": 279, "protein_name": "Cation-dependent mannose-6-phosphate receptor", "gene_name": "M6PR", "organism": "Bovine", "refseq_name": "cation-dependent mannose-6-phosphate receptor precursor", "refseq_ac": [ { "id": "NP_786973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786973", "type": "external" } ], "gene_names_uniprotkb": "M6PR", "gene_names_refseq": "CD-MPR; CDMPR; M6PR", "protein_names_uniprotkb": "Cation-dependent mannose-6-phosphate receptor; 46 kDa mannose 6-phosphate receptor; CD Man-6-P receptor; CD-MPR; MPR 46", "protein_names_refseq": "46 kDa mannose 6-phosphate receptor; CD Man-6-P receptor; MPR 46; cation-dependent mannose-6-phosphate receptor precursor; cation-dependent mannose-6-phosphate receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281291); (R-BTA-432720); (R-BTA-6811440); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-9840310)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10514470;11786557;12127995;16305752;18272523;19928875;24501398;2544594;2954652;7559753;9604938", "class_list": "", "function": "Expression and binding properties of mannose-6-phosphate receptors CD-MPR and CI-MPR differ during perinatal development in rat liver., [RefSeq, PubMed]; Rotaviruses reach late endosomes and require M6PR and cathepsin proteases to enter the cell., [RefSeq, PubMed]; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A1L5A0;Q0VCN7", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:1905394 retromer complex binding", "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane;GO:0005770 late endosome", "go_biological_process": "GO:0006622 protein targeting to lysosome;GO:0007041 lysosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P11456-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05632-1", "uniprot_id": [ { "id": "ATP5E_BOVIN", "url": "https://www.uniprot.org/uniprot/P05632", "type": "external" } ], "mass": 5783.0, "length": 51, "protein_name": "ATP synthase F(1) complex subunit epsilon, mitochondrial", "gene_name": "ATP5F1E; LOC132343467", "organism": "Bovine", "refseq_name": "ATP synthase F(1) complex subunit epsilon, mitochondrial", "refseq_ac": [ { "id": "NP_001137213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137213", "type": "external" } ], "gene_names_uniprotkb": "ATP5F1E; LOC132343467; ATP5E", "gene_names_refseq": "ATP5E; ATP5F1E", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit epsilon, mitochondrial; ATP synthase F1 subunit epsilon; ATPase subunit epsilon", "protein_names_refseq": "ATP synthase F(1) complex subunit epsilon, mitochondrial; ATP synthase subunit epsilon, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit; ATPase subunit epsilon", "tax_id": 9913, "disease": "", "pathway": " (bta:617230); (R-BTA-163210); (R-BTA-8949613)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "17570365;17895376;1827992;2137333;25851905;2864455;8065448", "class_list": "", "function": "Subunit epsilon, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). May be essential for the assembly of F(1) and may play an important role in the incorporation of the hydrophobic subunit c into the F(1)-c oligomer rotor of the mitochondrial ATP synthase complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32PE5", "ec_number_list": [], "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P05632-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35605-1", "uniprot_id": [ { "id": "COPB2_BOVIN", "url": "https://www.uniprot.org/uniprot/P35605", "type": "external" } ], "mass": 102393.0, "length": 906, "protein_name": "Coatomer subunit beta'", "gene_name": "COPB2", "organism": "Bovine", "refseq_name": "coatomer subunit beta'", "refseq_ac": [ { "id": "NP_776706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776706", "type": "external" } ], "gene_names_uniprotkb": "COPB2", "gene_names_refseq": "COPB2", "protein_names_uniprotkb": "Coatomer subunit beta'; Beta'-COP; Beta'-coat protein; p102", "protein_names_refseq": "beta'-COP; beta'-coat protein; coatomer protein complex subunit beta 2; coatomer protein complex, subunit beta 2 (beta prime); coatomer subunit beta'; p102", "tax_id": 9913, "disease": "", "pathway": " (bta:281706); (R-BTA-6807878); (R-BTA-6811434)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "8334999;9548716", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4IFE1", "ec_number_list": [], "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030126 COPI vesicle coat;GO:0030117 membrane coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35605-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23132-1", "uniprot_id": [ { "id": "LITH_BOVIN", "url": "https://www.uniprot.org/uniprot/P23132", "type": "external" } ], "mass": 19334.0, "length": 175, "protein_name": "Lithostathine", "gene_name": "PTP; REG3A", "organism": "Bovine", "refseq_name": "lithostathine precursor", "refseq_ac": [ { "id": "NP_991356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991356", "type": "external" } ], "gene_names_uniprotkb": "PTP; REG3A", "gene_names_refseq": "PTP; REG3A", "protein_names_uniprotkb": "Lithostathine; ICRF; Islet cells regeneration factor; Islet of Langerhans regenerating protein; PSP; PTP; Pancreatic stone protein; Pancreatic thread protein; REG", "protein_names_refseq": "ICRF; PSP; REG; islet cells regeneration factor; islet of Langerhans regenerating protein; lithostathine precursor; lithostathine; pancreatic stone protein; pancreatic thread protein", "tax_id": 9913, "disease": "", "pathway": " (bta:404114); (R-BTA-6803157)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "2085387;2394826;3862086", "class_list": "", "function": "Might act as an inhibitor of spontaneous calcium carbonate precipitation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P23132-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H7BWW2-1", "uniprot_id": [ { "id": "H7BWW2_BOVIN", "url": "https://www.uniprot.org/uniprot/H7BWW2", "type": "external" } ], "mass": 61262.0, "length": 537, "protein_name": "Beta-hexosaminidase", "gene_name": "HEXB", "organism": "Bovine", "refseq_name": "beta-hexosaminidase subunit beta preproprotein", "refseq_ac": [ { "id": "NP_001069978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069978", "type": "external" } ], "gene_names_uniprotkb": "HEXB", "gene_names_refseq": "HEXB", "protein_names_uniprotkb": "Beta-hexosaminidase; 3.2.1.52", "protein_names_refseq": "N-acetyl-beta-glucosaminidase; beta-N-acetylhexosaminidase; beta-hexosaminidase subunit beta preproprotein; hexosaminidase B (beta polypeptide)", "tax_id": 9913, "disease": "", "pathway": " (bta:618571); (R-BTA-2022857); (R-BTA-2024101); (R-BTA-2160916); (R-BTA-6798695); (R-BTA-9840310)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004563 beta-N-acetylhexosaminidase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0060473 cortical granule;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0005975 carbohydrate metabolic process;GO:1901135 carbohydrate derivative metabolic process;GO:0006689 ganglioside catabolic process;GO:0030203 glycosaminoglycan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "H7BWW2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N186-1", "uniprot_id": [ { "id": "G3N186_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N186", "type": "external" } ], "mass": 63853.0, "length": 562, "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "PARP2", "organism": "Bovine", "refseq_name": "poly [ADP-ribose] polymerase 2", "refseq_ac": [ { "id": "XP_005211593", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211593", "type": "external" } ], "gene_names_uniprotkb": "PARP2", "gene_names_refseq": "PARP2", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase; 2.4.2.-; PARP", "protein_names_refseq": "poly [ADP-ribose] polymerase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:505828); (R-BTA-110362); (R-BTA-5685939); (R-BTA-5696394); (R-BTA-5696395); (R-BTA-5696400)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0072572 poly-ADP-D-ribose binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006281 DNA repair;GO:0070213 protein auto-ADP-ribosylation;GO:0006302 double-strand break repair;GO:0046697 decidualization;GO:0070212 protein poly-ADP-ribosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N186-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07318-1", "uniprot_id": [ { "id": "CRBB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P07318", "type": "external" } ], "mass": 28144.0, "length": 253, "protein_name": "Beta-crystallin B1", "gene_name": "CRYBB1", "organism": "Bovine", "refseq_name": "beta-crystallin B1", "refseq_ac": [ { "id": "NP_776951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776951", "type": "external" } ], "gene_names_uniprotkb": "CRYBB1", "gene_names_refseq": "CRYBB1", "protein_names_uniprotkb": "Beta-crystallin B1; Beta-B1 crystallin", "protein_names_refseq": "beta-B1 crystallin; beta-crystallin B1", "tax_id": 9913, "disease": "", "pathway": " (bta:282205)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "6527379;6698025", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P07318-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N0C2-1", "uniprot_id": [ { "id": "G3N0C2_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N0C2", "type": "external" } ], "mass": 157019.0, "length": 1441, "protein_name": "Nuclear receptor coactivator", "gene_name": "NCOA1", "organism": "Bovine", "refseq_name": "nuclear receptor coactivator 1", "refseq_ac": [ { "id": "NP_001193144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193144", "type": "external" } ], "gene_names_uniprotkb": "NCOA1", "gene_names_refseq": "NCOA1", "protein_names_uniprotkb": "Nuclear receptor coactivator", "protein_names_refseq": "nuclear receptor coactivator 1", "tax_id": 9913, "disease": "", "pathway": " (bta:525346); (R-BTA-159418); (R-BTA-192105); (R-BTA-193368); (R-BTA-193807); (R-BTA-211976); (R-BTA-3214847); (R-BTA-3899300); (R-BTA-400206); (R-BTA-9018519); (R-BTA-9029569); (R-BTA-9623433); (R-BTA-9707564); (R-BTA-9841922)", "pathway_count": 14, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0003713 transcription coactivator activity;GO:0046983 protein dimerization activity;GO:0016922 nuclear receptor binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043065 positive regulation of apoptotic process;GO:0045666 positive regulation of neuron differentiation;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N0C2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRW8-1", "uniprot_id": [ { "id": "RN169_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRW8", "type": "external" } ], "mass": 75630.0, "length": 689, "protein_name": "E3 ubiquitin-protein ligase RNF169", "gene_name": "RNF169", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RNF169", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF169; 2.3.2.27; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization. Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0031491 nucleosome binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break", "go_biological_process": "GO:2000780 negative regulation of double-strand break repair;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MRW8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRZ2-1", "uniprot_id": [ { "id": "F1MRZ2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRZ2", "type": "external" } ], "mass": 101850.0, "length": 934, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 5", "gene_name": "ADAMTS5", "organism": "Bovine", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor", "refseq_ac": [ { "id": "NP_001159987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159987", "type": "external" } ], "gene_names_uniprotkb": "ADAMTS5", "gene_names_refseq": "ADAMTS5", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 5; ADMP-2; Aggrecanase-2", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor; ADAM-TS 5; ADAM-TS5; ADAMTS-5; ADMP-2; a disintegrin and metalloproteinase with thrombospondin motifs 5; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5; aggrecanase-2", "tax_id": 9913, "disease": "", "pathway": " (bta:286805); (R-BTA-1474228); (R-BTA-5173214)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "14715656;19101611;19607802;21055468", "class_list": "", "function": "ADAMTS4 and ADAMTS5 are inhibited by alpha2-macroglobulin, [RefSeq, PubMed]; Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production., [RefSeq, PubMed]; Identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5, [RefSeq, PubMed]; The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase) explains the minor contribution of the MMP enzymes to aggrecan catabolism in vivo., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008201 heparin binding;GO:0008270 zinc ion binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0022617 extracellular matrix disassembly;GO:0030198 extracellular matrix organization;GO:0007520 myoblast fusion;GO:0003203 endocardial cushion morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1MRZ2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MSN4-1", "uniprot_id": [ { "id": "F1MSN4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MSN4", "type": "external" } ], "mass": 21246.0, "length": 192, "protein_name": "Interleukin-23 subunit alpha", "gene_name": "IL23A", "organism": "Bovine", "refseq_name": "interleukin-23 subunit alpha precursor", "refseq_ac": [ { "id": "NP_001192617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192617", "type": "external" } ], "gene_names_uniprotkb": "IL23A", "gene_names_refseq": "IL-23; IL23A", "protein_names_uniprotkb": "Interleukin-23 subunit alpha; Interleukin-23 subunit p19", "protein_names_refseq": "interleukin 23, alpha subunit p19; interleukin-23 subunit alpha precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:511022); (R-BTA-9020933)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "31733610", "class_list": "", "function": "Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells., [UniProtKB, UniProtKB]; The Th17 driving cytokine IL-23 expressed by infected macrophages and associated epithelial cells may contribute to chronic inflammation during later stages of Johne's disease. [review] Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045519 interleukin-23 receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0070743 interleukin-23 complex", "go_biological_process": "GO:0051142 positive regulation of NK T cell proliferation;GO:0032693 negative regulation of interleukin-10 production;GO:0032740 positive regulation of interleukin-17 production;GO:0006954 inflammatory response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MSN4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MWN2-1", "uniprot_id": [ { "id": "F1MWN2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MWN2", "type": "external" } ], "mass": 59496.0, "length": 525, "protein_name": "Tyrosine-protein kinase", "gene_name": "HCK", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HCK", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:280814); (R-BTA-912631); (R-BTA-9674555); (R-BTA-9705462)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0001784 phosphotyrosine residue binding;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005925 focal adhesion", "go_biological_process": "GO:0071801 regulation of podosome assembly;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MWN2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MTK6-1", "uniprot_id": [ { "id": "F1MTK6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MTK6", "type": "external" } ], "mass": 71951.0, "length": 633, "protein_name": "Membrane-type matrix metalloproteinase 1", "gene_name": "MMP24", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MMP24", "gene_names_refseq": "", "protein_names_uniprotkb": "Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1592389)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0045296 cadherin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0050965 detection of temperature stimulus involved in sensory perception of pain;GO:0030574 collagen catabolic process;GO:0097150 neuronal stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MTK6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MTR3-1", "uniprot_id": [ { "id": "F1MTR3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MTR3", "type": "external" } ], "mass": 145779.0, "length": 1279, "protein_name": "Paired amphipathic helix protein Sin3a", "gene_name": "SIN3A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SIN3A", "gene_names_refseq": "", "protein_names_uniprotkb": "Paired amphipathic helix protein Sin3a; Histone deacetylase complex subunit Sin3a; Transcriptional corepressor Sin3a", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3899300); (R-BTA-400206); (R-BTA-8936459); (R-BTA-9022692); (R-BTA-9707564); (R-BTA-9824594); (R-BTA-9825892)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0017053 transcription repressor complex;GO:0000776 kinetochore;GO:0000785 chromatin;GO:0070822 Sin3-type complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045666 positive regulation of neuron differentiation;GO:1900181 negative regulation of protein localization to nucleus;GO:0060337 type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MTR3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MTX6-1", "uniprot_id": [ { "id": "F1MTX6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MTX6", "type": "external" } ], "mass": 54415.0, "length": 477, "protein_name": "Stromelysin-1", "gene_name": "MMP3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MMP3", "gene_names_refseq": "", "protein_names_uniprotkb": "Stromelysin-1; 3.4.24.17; Matrix metalloproteinase-3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1442490); (R-BTA-1474228); (R-BTA-1592389); (R-BTA-9009391)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.7", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0045087 innate immune response;GO:0031334 positive regulation of protein-containing complex assembly;GO:2000378 negative regulation of reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MTX6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MV20-1", "uniprot_id": [ { "id": "F1MV20_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MV20", "type": "external" } ], "mass": 50389.0, "length": 485, "protein_name": "mRNA decay activator protein ZFP36", "gene_name": "ZFP36L2", "organism": "Bovine", "refseq_name": "mRNA decay activator protein ZFP36L2", "refseq_ac": [ { "id": "NP_001178120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178120", "type": "external" } ], "gene_names_uniprotkb": "ZFP36L2", "gene_names_refseq": "ZFP36L2", "protein_names_uniprotkb": "mRNA decay activator protein ZFP36; Zinc finger protein 36", "protein_names_refseq": "butyrate response factor 2; mRNA decay activator protein ZFP36L2; zinc finger protein 36, C3H type-like 2", "tax_id": 9913, "disease": "", "pathway": " (bta:767898)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0008270 zinc ion binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0160134 protein-RNA sequence-specific adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex;GO:0000178 exosome (RNase complex)", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0009611 response to wounding;GO:0070371 ERK1 and ERK2 cascade;GO:0071560 cellular response to transforming growth factor beta stimulus;GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MV20-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MVI5-1", "uniprot_id": [ { "id": "F1MVI5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MVI5", "type": "external" } ], "mass": 70608.0, "length": 630, "protein_name": "A-type voltage-gated potassium channel KCND2", "gene_name": "KCND2", "organism": "Bovine", "refseq_name": "A-type voltage-gated potassium channel KCND2", "refseq_ac": [ { "id": "NP_001178113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178113", "type": "external" } ], "gene_names_uniprotkb": "KCND2", "gene_names_refseq": "KCND2", "protein_names_uniprotkb": "A-type voltage-gated potassium channel KCND2; Potassium voltage-gated channel subfamily D member 2; Voltage-gated potassium channel subunit Kv4.2", "protein_names_refseq": "A-type voltage-gated potassium channel KCND2; potassium voltage-gated channel, Shal-related subfamily, member 2", "tax_id": 9913, "disease": "", "pathway": " (bta:540416); (R-BTA-1296072); (R-BTA-5576894)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:1905030 voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005250 A-type (transient outward) potassium channel activity", "go_cellular_component": "GO:0043025 neuronal cell body;GO:0043197 dendritic spine;GO:0043204 perikaryon;GO:0045211 postsynaptic membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MVI5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MVS4-1", "uniprot_id": [ { "id": "F1MVS4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MVS4", "type": "external" } ], "mass": 22596.0, "length": 206, "protein_name": "Nucleolar protein 3", "gene_name": "NOL3", "organism": "Bovine", "refseq_name": "nucleolar protein 3 isoform X1", "refseq_ac": [ { "id": "XP_015331227", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015331227", "type": "external" } ], "gene_names_uniprotkb": "NOL3", "gene_names_refseq": "NOL3", "protein_names_uniprotkb": "Nucleolar protein 3; Apoptosis repressor with CARD", "protein_names_refseq": "nucleolar protein 3 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0035877 death effector domain binding;GO:0089720 caspase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0002931 response to ischemia;GO:0051259 protein complex oligomerization;GO:0001974 blood vessel remodeling;GO:0097193 intrinsic apoptotic signaling pathway;GO:2001237 negative regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MVS4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MVX2-1", "uniprot_id": [ { "id": "LANC1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MVX2", "type": "external" } ], "mass": 45309.0, "length": 399, "protein_name": "Glutathione S-transferase LANCL1", "gene_name": "LANCL1", "organism": "Bovine", "refseq_name": "glutathione S-transferase LANCL1", "refseq_ac": [ { "id": "NP_001069695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069695", "type": "external" } ], "gene_names_uniprotkb": "LANCL1", "gene_names_refseq": "LANCL1; p40", "protein_names_uniprotkb": "Glutathione S-transferase LANCL1; 2.5.1.18; 40 kDa erythrocyte membrane protein; LanC-like protein 1; p40", "protein_names_refseq": "40 kDa erythrocyte membrane protein; LanC lantibiotic synthetase component C-like 1; LanC like 1; glutathione S-transferase LANCL1; lanC-like protein 1; lanthionine synthase C-like protein-1", "tax_id": 9913, "disease": "", "pathway": " (bta:540559)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17305318;19393038", "class_list": "", "function": "Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling (By similarity). Binds glutathione (PubMed:17305318)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; These results indicate LanCL1 is a glutathione binding protein possibly significant to neurodegenerative disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZH8", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "4.1.1.84", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.84", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0031179 peptide modification;GO:1990748 cellular detoxification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1MVX2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MW26-1", "uniprot_id": [ { "id": "F1MW26_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MW26", "type": "external" } ], "mass": 54069.0, "length": 471, "protein_name": "Collagenase 3", "gene_name": "MMP13", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MMP13", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagenase 3; Matrix metalloproteinase-13", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1442490); (R-BTA-1474228); (R-BTA-1592389)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0022617 extracellular matrix disassembly;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MW26-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MX49-1", "uniprot_id": [ { "id": "F1MX49_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MX49", "type": "external" } ], "mass": 122894.0, "length": 1089, "protein_name": "Platelet-derived growth factor receptor alpha", "gene_name": "PDGFRA", "organism": "Bovine", "refseq_name": "platelet-derived growth factor receptor alpha precursor", "refseq_ac": [ { "id": "NP_001179274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179274", "type": "external" } ], "gene_names_uniprotkb": "PDGFRA", "gene_names_refseq": "PDGFRA", "protein_names_uniprotkb": "Platelet-derived growth factor receptor alpha; 2.7.10.1; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; PDGF-R-alpha; PDGFR-alpha", "protein_names_refseq": "platelet-derived growth factor receptor alpha precursor; platelet-derived growth factor receptor, alpha polypeptide", "tax_id": 9913, "disease": "", "pathway": " (bta:282301); (R-BTA-1257604); (R-BTA-186763); (R-BTA-186797); (R-BTA-5673001); (R-BTA-6811558)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32485948", "class_list": "", "function": "A Novel Mechanism of bta-miR-210 in Bovine Early Intramuscular Adipogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005018 platelet-derived growth factor alpha-receptor activity;GO:0048407 platelet-derived growth factor binding;GO:0005161 platelet-derived growth factor receptor binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0043235 receptor complex;GO:0005634 nucleus", "go_biological_process": "GO:0006935 chemotaxis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MX49-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXQ0-1", "uniprot_id": [ { "id": "F1MXQ0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXQ0", "type": "external" } ], "mass": 178488.0, "length": 1607, "protein_name": "ADAM metallopeptidase with thrombospondin type 1 motif 12", "gene_name": "ADAMTS12", "organism": "Bovine", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor", "refseq_ac": [ { "id": "NP_001179538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179538", "type": "external" } ], "gene_names_uniprotkb": "ADAMTS12", "gene_names_refseq": "ADAMTS12", "protein_names_uniprotkb": "ADAM metallopeptidase with thrombospondin type 1 motif 12", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:525276); (R-BTA-5173214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0006508 proteolysis;GO:0016477 cell migration;GO:0030198 extracellular matrix organization;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXQ0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MY71-1", "uniprot_id": [ { "id": "F1MY71_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MY71", "type": "external" } ], "mass": 72494.0, "length": 667, "protein_name": "Leucine zipper putative tumor suppressor 2", "gene_name": "LZTS2", "organism": "Bovine", "refseq_name": "leucine zipper putative tumor suppressor 2 isoform X1", "refseq_ac": [ { "id": "XP_005225514", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225514", "type": "external" } ], "gene_names_uniprotkb": "LZTS2; LAPSER1", "gene_names_refseq": "LAPSER1; LZTS2", "protein_names_uniprotkb": "Leucine zipper putative tumor suppressor 2; Protein LAPSER1", "protein_names_refseq": "leucine zipper putative tumor suppressor 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0031982 vesicle;GO:0030496 midbody", "go_biological_process": "GO:0051013 microtubule severing;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0000281 mitotic cytokinesis;GO:0051168 nuclear export", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MY71-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MY97-1", "uniprot_id": [ { "id": "F1MY97_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MY97", "type": "external" } ], "mass": 94816.0, "length": 836, "protein_name": "pre-rRNA processing protein FTSJ3", "gene_name": "FTSJ3", "organism": "Bovine", "refseq_name": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 isoform X1", "refseq_ac": [ { "id": "XP_024835631", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835631", "type": "external" } ], "gene_names_uniprotkb": "FTSJ3", "gene_names_refseq": "FTSJ3", "protein_names_uniprotkb": "pre-rRNA processing protein FTSJ3; 2'-O-ribose RNA methyltransferase SPB1 homolog; 2.1.1.-; Protein ftsJ homolog 3; Putative rRNA methyltransferase 3", "protein_names_refseq": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6791226)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, 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"0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MYM3-1", "uniprot_id": [ { "id": "F1MYM3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MYM3", "type": "external" } ], "mass": 123371.0, "length": 1075, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform", "gene_name": "PIK3CB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PIK3CB", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; 2.7.1.153; 2.7.11.1; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; Serine/threonine protein kinase PIK3CB", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-109704); (R-BTA-112399); (R-BTA-114604); (R-BTA-1257604); (R-BTA-1660499); (R-BTA-186763); (R-BTA-198203); (R-BTA-201556); (R-BTA-202424); (R-BTA-2029485); 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The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. 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Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 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"kg_view_protein": true }, { "uniprot_canonical_ac": "G3MWN1-1", "uniprot_id": [ { "id": "G3MWN1_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MWN1", "type": "external" } ], "mass": 50181.0, "length": 462, "protein_name": "Arginase-2, mitochondrial", "gene_name": "ARG2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ARG2", "gene_names_refseq": "", "protein_names_uniprotkb": "Arginase-2, mitochondrial; 3.5.3.1; Arginase II; Type II arginase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-70635); (R-BTA-9837999)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, 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"type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.5.3.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.17", "type": "external" }, { "id": "3.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.7", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", 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"type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004053 arginase activity;GO:0030145 manganese ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005737 cytoplasm", "go_biological_process": "GO:0000050 urea cycle;GO:0006525 arginine metabolic process;GO:0051241 negative regulation of multicellular organismal process;GO:0032700 negative regulation of interleukin-17 production;GO:0032651 regulation of interleukin-1 beta production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MWN1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N2V0-1", "uniprot_id": [ { "id": "F1N2V0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N2V0", "type": "external" } ], "mass": 134433.0, "length": 1281, "protein_name": "Crumbs cell polarity complex component 2", "gene_name": "CRB2", "organism": "Bovine", "refseq_name": "protein crumbs homolog 2", "refseq_ac": [ { "id": "XP_003586718", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586718", "type": "external" } ], "gene_names_uniprotkb": "CRB2", "gene_names_refseq": "CRB2", "protein_names_uniprotkb": "Crumbs cell polarity complex component 2", "protein_names_refseq": "protein crumbs homolog 2", "tax_id": 9913, "disease": "", "pathway": " (bta:786516)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, 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regulation of gastrulation;GO:0055111 ingression involved in gastrulation with mouth forming second;GO:0072359 circulatory system development;GO:0045494 photoreceptor cell maintenance;GO:0001756 somitogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N2V0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N2Z3-1", "uniprot_id": [ { "id": "F1N2Z3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N2Z3", "type": "external" } ], "mass": 39880.0, "length": 356, "protein_name": "Neurogenic differentiation factor", "gene_name": "NEUROD1", "organism": "Bovine", "refseq_name": "neurogenic differentiation factor 1 isoform X1", "refseq_ac": [ { "id": "XP_005202327", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202327", "type": "external" } ], "gene_names_uniprotkb": "NEUROD1", "gene_names_refseq": "NEUROD1", "protein_names_uniprotkb": "Neurogenic 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Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. 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Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N3F6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N3J7-1", "uniprot_id": [ { "id": "F1N3J7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N3J7", "type": "external" } ], "mass": 81540.0, "length": 734, "protein_name": "Sulfate transporter", "gene_name": "SLC26A2", "organism": "Bovine", "refseq_name": "sulfate transporter isoform X1", "refseq_ac": [ { "id": "XP_005209630", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209630", "type": "external" } ], "gene_names_uniprotkb": "SLC26A2", "gene_names_refseq": "SLC26A2", "protein_names_uniprotkb": "Sulfate transporter; Solute carrier family 26 member 2", "protein_names_refseq": "sulfate transporter isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-174362); (R-BTA-427601)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019531 oxalate transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0002062 chondrocyte differentiation;GO:0035988 chondrocyte proliferation;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N3J7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N3Q4-1", "uniprot_id": [ { "id": "F1N3Q4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N3Q4", "type": "external" } ], "mass": 42377.0, "length": 388, "protein_name": "Paralemmin-1", "gene_name": "PALM", "organism": "Bovine", "refseq_name": "paralemmin-1 isoform X2", "refseq_ac": [ { "id": "XP_024850865", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850865", "type": "external" } ], "gene_names_uniprotkb": "PALM", "gene_names_refseq": "PALM", "protein_names_uniprotkb": "Paralemmin-1; Paralemmin", "protein_names_refseq": "paralemmin-1 isoform X2", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031750 D3 dopamine receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0016323 basolateral plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0060160 negative regulation of dopamine receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0072659 protein localization to plasma membrane;GO:0008360 regulation of cell shape;GO:0051491 positive regulation of filopodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N3Q4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N4C5-1", "uniprot_id": [ { "id": "F1N4C5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N4C5", "type": "external" } ], "mass": 212020.0, "length": 1931, "protein_name": "Plexin-D1", "gene_name": "PLXND1", "organism": "Bovine", "refseq_name": "plexin-D1", "refseq_ac": [ { "id": "XP_002697168", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697168", "type": "external" } ], "gene_names_uniprotkb": "PLXND1", "gene_names_refseq": "PLXND1", "protein_names_uniprotkb": "Plexin-D1", "protein_names_refseq": "plexin-D1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-416700); (R-BTA-9696270)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0030424 axon", "go_biological_process": "GO:0001525 angiogenesis;GO:0007162 negative regulation of cell adhesion;GO:0071526 semaphorin-plexin signaling pathway;GO:0043524 negative regulation of neuron apoptotic process;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N4C5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N4K7-1", "uniprot_id": [ { "id": "F1N4K7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N4K7", "type": "external" } ], "mass": 63782.0, "length": 574, "protein_name": "Frizzled class receptor 7", "gene_name": "FZD7", "organism": "Bovine", "refseq_name": "frizzled-7 precursor", "refseq_ac": [ { "id": "NP_001137563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137563", "type": "external" } ], "gene_names_uniprotkb": "FZD7", "gene_names_refseq": "FZD7", "protein_names_uniprotkb": "Frizzled class receptor 7", "protein_names_refseq": "frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; frizzled-7 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:524255); (R-BTA-4086400); (R-BTA-4608870)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "17273804;33686687", "class_list": "", "function": "A missense mutation in the FZD7 gene is associated with dilution of the red areas of the coat in Montbeliarde cattle., [RefSeq, PubMed]; Chimpanzee FZD7 and cow Fzd7 genes were identified and characterized., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005109 frizzled binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0030165 PDZ domain binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0045893 positive regulation of DNA-templated transcription;GO:0019827 stem cell population maintenance;GO:0042327 positive regulation of phosphorylation;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1N4K7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N5C5-1", "uniprot_id": [ { "id": "F1N5C5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N5C5", "type": "external" } ], "mass": 51433.0, "length": 460, "protein_name": "Muscarinic acetylcholine receptor", "gene_name": "CHRM1", "organism": "Bovine", "refseq_name": "muscarinic acetylcholine receptor M1", "refseq_ac": [ { "id": "NP_001231538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231538", "type": "external" } ], "gene_names_uniprotkb": "CHRM1", "gene_names_refseq": "CHRM1", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor", "protein_names_refseq": "muscarinic acetylcholine receptor M1", "tax_id": 9913, "disease": "", "pathway": " (bta:281684); (R-BTA-390648); (R-BTA-416476)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "12644723", "class_list": "", "function": "Results suggest that the cyclic ADP-ribose signaling pathway participates in the contraction of small coronary arterial smooth muscle and Ca(2+) release induced by activation of M(1) muscarinic receptors, [RefSeq, PubMed]; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0098981 cholinergic synapse", "go_biological_process": "GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0040012 regulation of locomotion;GO:0046541 saliva secretion;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1N5C5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N5D8-1", "uniprot_id": [ { "id": "F1N5D8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N5D8", "type": "external" } ], "mass": 36778.0, "length": 336, "protein_name": "Ileal sodium/bile acid cotransporter", "gene_name": "SLC10A2", "organism": "Bovine", "refseq_name": "ileal sodium/bile acid cotransporter isoform X1", "refseq_ac": [ { "id": "XP_024855933", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855933", "type": "external" } ], "gene_names_uniprotkb": "SLC10A2", "gene_names_refseq": "SLC10A2", "protein_names_uniprotkb": "Ileal sodium/bile acid cotransporter; Apical sodium-dependent bile acid transporter; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; Na(+)-dependent ileal bile acid transporter; Solute carrier family 10 member 2", "protein_names_refseq": "ileal sodium/bile acid cotransporter isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:525823); (R-BTA-159418)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008508 bile acid:sodium symporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0005902 microvillus", "go_biological_process": "GO:0015721 bile acid and bile salt transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N5D8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N5R9-1", "uniprot_id": [ { "id": "F1N5R9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N5R9", "type": "external" } ], "mass": 40795.0, "length": 400, "protein_name": "Homeobox protein engrailed-like", "gene_name": "EN1", "organism": "Bovine", "refseq_name": "homeobox protein engrailed-1", "refseq_ac": [ { "id": "XP_003585804", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585804", "type": "external" } ], "gene_names_uniprotkb": "EN1", "gene_names_refseq": "EN1", "protein_names_uniprotkb": "Homeobox protein engrailed-like", "protein_names_refseq": "homeobox protein engrailed-1", "tax_id": 9913, "disease": "", "pathway": " (bta:529707)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008344 adult locomotory behavior;GO:0043524 negative regulation of neuron apoptotic process;GO:0030182 neuron differentiation;GO:0042756 drinking behavior", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N5R9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N650-1", "uniprot_id": [ { "id": "F1N650_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N650", "type": "external" } ], "mass": 38980.0, "length": 346, "protein_name": "Annexin", "gene_name": "ANXA1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ANXA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Annexin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-416476)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0019834 phospholipase A2 inhibitor activity;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0046883 regulation of hormone secretion;GO:0006909 phagocytosis;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N650-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N6S4-1", "uniprot_id": [ { "id": "F1N6S4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N6S4", "type": "external" } ], "mass": 71169.0, "length": 625, "protein_name": "Grainyhead like transcription factor 2", "gene_name": "GRHL2", "organism": "Bovine", "refseq_name": "grainyhead-like protein 2 homolog isoform X1", "refseq_ac": [ { "id": "XP_002692840", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692840", "type": "external" } ], "gene_names_uniprotkb": "GRHL2", "gene_names_refseq": "GRHL2", "protein_names_uniprotkb": "Grainyhead like transcription factor 2", "protein_names_refseq": "grainyhead-like protein 2 homolog isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:519918)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0001161 intronic transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005911 cell-cell junction", "go_biological_process": "GO:0090132 epithelium migration;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007155 cell adhesion;GO:0030216 keratinocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N6S4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N6W0-1", "uniprot_id": [ { "id": "F1N6W0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N6W0", "type": "external" } ], "mass": 50020.0, "length": 469, "protein_name": "Transcription factor SOX-10", "gene_name": "SOX10", "organism": "Bovine", "refseq_name": "transcription factor SOX-10", "refseq_ac": [ { "id": "NP_001180176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180176", "type": "external" } ], "gene_names_uniprotkb": "SOX10", "gene_names_refseq": "SOX10; SOX9", "protein_names_uniprotkb": "Transcription factor SOX-10", "protein_names_refseq": "SRY (sex determining region Y)-box 10; SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal); SRY-box 10; transcription factor SOX-10", "tax_id": 9913, "disease": "", "pathway": " (bta:353115); (R-BTA-9856649)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, 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"secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0022010 central nervous system myelination;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N6W0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N6Y9-1", "uniprot_id": [ { "id": "F1N6Y9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N6Y9", "type": "external" } ], "mass": 331150.0, "length": 3045, "protein_name": "Cadherin EGF LAG seven-pass G-type receptor 1", "gene_name": "CELSR1", "organism": "Bovine", "refseq_name": "cadherin EGF LAG seven-pass G-type receptor 1 isoform X1", "refseq_ac": [ { "id": "XP_024848690", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848690", "type": "external" } ], "gene_names_uniprotkb": "CELSR1", "gene_names_refseq": "CELSR1", "protein_names_uniprotkb": "Cadherin EGF LAG seven-pass G-type receptor 1", "protein_names_refseq": "cadherin EGF LAG seven-pass G-type receptor 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:522422)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor that may have an important role in cell/cell signaling during nervous system formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007409 axonogenesis;GO:0001843 neural tube closure;GO:0009952 anterior/posterior pattern specification;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N6Y9-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N7C5-1", "uniprot_id": [ { "id": "F1N7C5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N7C5", "type": "external" } ], "mass": 50682.0, "length": 454, "protein_name": "Indoleamine 2,3-dioxygenase 1", "gene_name": "IDO1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IDO1", "gene_names_refseq": "", "protein_names_uniprotkb": "Indoleamine 2,3-dioxygenase 1; 1.13.11.52; IDO-1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the first and rate limiting step of the catabolism of tryptophan along the kynurenine pathway. Involved in immune regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.52", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.52", "type": "external" }, { "id": "1.13.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.11", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004833 L-tryptophan 2,3-dioxygenase activity;GO:0033754 indoleamine 2,3-dioxygenase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030485 smooth muscle contractile fiber;GO:0032421 stereocilium bundle", "go_biological_process": "GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0019805 quinolinate biosynthetic process;GO:0070234 positive regulation of T cell apoptotic process;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N7C5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N7S0-1", "uniprot_id": [ { "id": "F1N7S0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N7S0", "type": "external" } ], "mass": 54683.0, "length": 493, "protein_name": "Tubby-like protein", "gene_name": "TULP3", "organism": "Bovine", "refseq_name": "tubby-related protein 3 isoform X2", "refseq_ac": [ { "id": "XP_059742385", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742385", "type": "external" } ], "gene_names_uniprotkb": "TULP3", "gene_names_refseq": "TULP3", "protein_names_uniprotkb": "Tubby-like protein", "protein_names_refseq": "tubby-related protein 3 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5610787)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": 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Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0044325 transmembrane transporter binding;GO:0042030 ATPase inhibitor activity;GO:0141110 transporter inhibitor activity", "go_cellular_component": "GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0016529 sarcoplasmic reticulum;GO:0033017 sarcoplasmic reticulum membrane;GO:0090534 calcium ion-transporting ATPase complex", "go_biological_process": "GO:0008542 visual learning;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0010459 negative regulation of heart rate;GO:0001675 acrosome assembly;GO:0045475 locomotor rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F2Z4I4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F2Z4J6-1", "uniprot_id": [ { "id": "F2Z4J6_BOVIN", "url": "https://www.uniprot.org/uniprot/F2Z4J6", "type": "external" } ], "mass": 34833.0, "length": 316, "protein_name": "Transcription initiation factor IIB", "gene_name": "GTF2B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GTF2B", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription initiation factor IIB; 2.3.1.48; General transcription factor TFIIB", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-674695); (R-BTA-6807505); (R-BTA-73776); (R-BTA-73779); (R-BTA-75953); (R-BTA-76042)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Also exhibits autoacetyltransferase activity that contributes to the activated transcription., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, 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"https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0008270 zinc ion binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0017025 TBP-class protein binding;GO:0016407 acetyltransferase activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0006352 DNA-templated transcription initiation;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0001174 transcriptional start site selection at RNA polymerase II promoter;GO:1990114 RNA polymerase II core 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"reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0090722 receptor-receptor interaction;GO:0001586 Gi/o-coupled serotonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0046883 regulation of hormone secretion;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0019229 regulation of vasoconstriction;GO:0035640 exploration behavior", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6Q2H9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6QFI8-1", "uniprot_id": [ { "id": "F6QFI8_BOVIN", "url": "https://www.uniprot.org/uniprot/F6QFI8", "type": "external" } ], "mass": 60427.0, "length": 534, "protein_name": "NOP53 ribosome biosis factor", "gene_name": "NOP53", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NOP53", "gene_names_refseq": "", "protein_names_uniprotkb": "NOP53 ribosome biosis factor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0002039 p53 binding;GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0001650 fibrillar center;GO:0033553 rDNA heterochromatin", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:1903006 positive regulation of protein K63-linked deubiquitination;GO:1990173 protein localization to nucleoplasm;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6QFI8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6R653-1", "uniprot_id": [ { "id": "F6R653_BOVIN", "url": "https://www.uniprot.org/uniprot/F6R653", "type": "external" } ], "mass": 55086.0, "length": 514, "protein_name": "Beta-1 adrenergic receptor", "gene_name": "ADRB1", "organism": "Bovine", "refseq_name": "beta-1 adrenergic receptor isoform X1", "refseq_ac": [ { "id": "XP_059737697", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737697", "type": "external" } ], "gene_names_uniprotkb": "ADRB1", "gene_names_refseq": "ADRB1", "protein_names_uniprotkb": "Beta-1 adrenergic receptor; Beta-1 adrenoreceptor", "protein_names_refseq": "beta-1 adrenergic receptor isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-390696); (R-BTA-418555)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway. Binds epinephrine and norepinephrine with approximately equal affinity. Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2. As part of the sympathetic nervous system, plays a role in the physiologic regulation of cardiac functions such as stimulation of cardiomyocyte contraction. Also delivers proapoptotic signals in cardiomyocytes. Involved in the regulation of sleep/wake behaviors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, 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arterial blood pressure;GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6R653-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RP02-1", "uniprot_id": [ { "id": "F6RP02_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RP02", "type": "external" } ], "mass": 39753.0, "length": 367, "protein_name": "Serine/threonine-protein kinase pim-2", "gene_name": "PIM2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PIM2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase pim-2; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:508424)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, 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"https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle;GO:0009615 response to virus;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6RP02-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RQT4-1", "uniprot_id": [ { "id": "F6RQT4_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RQT4", "type": "external" } ], "mass": 43627.0, "length": 389, "protein_name": "Nucleic acid dioxygenase ALKBH1", "gene_name": "ALKBH1", "organism": "Bovine", "refseq_name": "nucleic acid dioxygenase ALKBH1 isoform 1", "refseq_ac": [ { "id": "NP_001421737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421737", "type": "external" } ], "gene_names_uniprotkb": "ALKBH1", "gene_names_refseq": "ALKBH1", "protein_names_uniprotkb": "Nucleic acid dioxygenase ALKBH1; 1.14.11.33; 1.14.11.51; 4.2.99.18; Alkylated DNA repair protein alkB homolog 1; Alpha-ketoglutarate-dependent dioxygenase ABH1; DNA 6mA demethylase; DNA N6-methyl adenine demethylase ALKBH1; DNA lyase ABH1; DNA oxidative demethylase ALKBH1; mRNA N(3)-methylcytidine demethylase", "protein_names_refseq": "alkB, alkylation repair homolog 1; alkylated DNA repair protein alkB homolog; nucleic acid dioxygenase ALKBH1 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"https://www.ncbi.nlm.nih.gov/protein/XP_024835624", "type": "external" } ], "gene_names_uniprotkb": "DHX58", "gene_names_refseq": "DHX58; LGP2", "protein_names_uniprotkb": "RNA helicase; 3.6.4.13", "protein_names_refseq": "ATP-dependent RNA helicase DHX58 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0039536 negative regulation of RIG-I signaling pathway;GO:0002753 cytoplasmic pattern recognition receptor signaling pathway;GO:0140374 antiviral innate immune response;GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N268-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MWR8-1", "uniprot_id": [ { "id": "MICA3_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MWR8", "type": "external" } ], "mass": 217545.0, "length": 1960, "protein_name": "[F-actin]-monooxygenase MICAL3", "gene_name": "MICAL3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MICAL3", "gene_names_refseq": "", "protein_names_uniprotkb": "[F-actin]-monooxygenase MICAL3; 1.14.13.225; MICAL-3; Molecule interacting with CasL protein 3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and play a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" } ], "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0120501 F-actin monooxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030496 midbody", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0006887 exocytosis;GO:0030042 actin filament depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3MWR8-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MXF3-1", "uniprot_id": [ { "id": "G3MXF3_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MXF3", "type": "external" } ], "mass": 41867.0, "length": 366, "protein_name": "Palmitoyltransferase", "gene_name": "ZDHHC2", "organism": "Bovine", "refseq_name": "palmitoyltransferase ZDHHC2", "refseq_ac": [ { "id": "XP_024842097", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842097", "type": "external" } ], "gene_names_uniprotkb": "ZDHHC2", "gene_names_refseq": "ZDHHC2", "protein_names_uniprotkb": "Palmitoyltransferase; 2.3.1.225", "protein_names_refseq": "palmitoyltransferase ZDHHC2", "tax_id": 9913, "disease": "", "pathway": " (bta:536310); (R-BTA-5683826)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0098837 postsynaptic recycling endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006612 protein targeting to membrane;GO:0022407 regulation of cell-cell adhesion;GO:0007416 synapse assembly;GO:1903076 regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MXF3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MXL6-1", "uniprot_id": [ { "id": "G3MXL6_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MXL6", "type": "external" } ], "mass": 41528.0, "length": 384, "protein_name": "Fructose-bisphosphate aldolase", "gene_name": "ALDOB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ALDOB", "gene_names_refseq": "", "protein_names_uniprotkb": "Fructose-bisphosphate aldolase; 4.1.2.13", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-70171); (R-BTA-70263); (R-BTA-70350)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde. Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0008092 cytoskeletal protein binding;GO:0004332 fructose-bisphosphate aldolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0034451 centriolar satellite", "go_biological_process": "GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0006096 glycolytic process;GO:0030388 fructose 1,6-bisphosphate metabolic process;GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly;GO:1905856 negative regulation of pentose-phosphate shunt", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MXL6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N1S4-1", "uniprot_id": [ { "id": "MCIN_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N1S4", "type": "external" } ], "mass": 40621.0, "length": 374, "protein_name": "Multicilin", "gene_name": "MCIDAS", "organism": "Bovine", "refseq_name": "multicilin", "refseq_ac": [ { "id": "XP_002696376", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696376", "type": "external" } ], "gene_names_uniprotkb": "MCIDAS; IDAS; MCIN; MCI", "gene_names_refseq": "MCIDAS", "protein_names_uniprotkb": "Multicilin; McIdas protein; Multiciliate differentiation and DNA synthesis-associated cell cycle protein; Protein Idas", "protein_names_refseq": "multicilin", "tax_id": 9913, "disease": "", "pathway": " (bta:100301340)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:1903251 multi-ciliated epithelial cell differentiation;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3N1S4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N248-1", "uniprot_id": [ { "id": "G3N248_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N248", "type": "external" } ], "mass": 50933.0, "length": 465, "protein_name": "One cut domain family member", "gene_name": "ONECUT1", "organism": "Bovine", "refseq_name": "hepatocyte nuclear factor 6", "refseq_ac": [ { "id": "NP_001178090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178090", "type": "external" } ], "gene_names_uniprotkb": "ONECUT1", "gene_names_refseq": "HNF-6a; ONECUT1", "protein_names_uniprotkb": "One cut domain family member", "protein_names_refseq": "hepatocyte nuclear factor 6 alpha; hepatocyte nuclear factor 6", "tax_id": 9913, "disease": "", "pathway": " (bta:503584)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N248-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N2D8-1", "uniprot_id": [ { "id": "G3N2D8_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N2D8", "type": "external" } ], "mass": 60874.0, "length": 568, "protein_name": "Glutathione hydrolase", "gene_name": "GGT1", "organism": "Bovine", "refseq_name": "glutathione hydrolase 1 proenzyme", "refseq_ac": [ { "id": "NP_001193143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193143", "type": "external" } ], "gene_names_uniprotkb": "GGT1", "gene_names_refseq": "GGT1", "protein_names_uniprotkb": "Glutathione hydrolase; 2.3.2.2; 3.4.19.13; Gamma-glutamyltransferase; Gamma-glutamyltranspeptidase", "protein_names_refseq": "glutathione hydrolase 1 proenzyme", "tax_id": 9913, "disease": "", "pathway": " (bta:615582); (R-BTA-174403); (R-BTA-2142691); (R-BTA-5423646); (R-BTA-9753281)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.2", "type": "external" }, { "id": "3.4.19.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.13", "type": "external" }, { "id": "3.4.19.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.14", "type": "external" } ], "go_molecular_function": "GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031982 vesicle", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0006751 glutathione catabolic process;GO:0002682 regulation of immune system process;GO:0050727 regulation of inflammatory response;GO:0019344 cysteine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N2D8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N354-1", "uniprot_id": [ { "id": "G3N354_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N354", "type": "external" } ], "mass": 57480.0, "length": 526, "protein_name": "Vesicular inhibitory amino acid transporter", "gene_name": "SLC32A1", "organism": "Bovine", "refseq_name": "vesicular inhibitory amino acid transporter", "refseq_ac": [ { "id": "XP_015329779", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329779", "type": "external" } ], "gene_names_uniprotkb": "SLC32A1", "gene_names_refseq": "SLC32A1", "protein_names_uniprotkb": "Vesicular inhibitory amino acid transporter; Solute carrier family 32 member 1; Vesicular GABA transporter", "protein_names_refseq": "vesicular inhibitory amino acid transporter", "tax_id": 9913, "disease": "", "pathway": " (bta:100301361); (R-BTA-442660); (R-BTA-888590)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity;GO:0140799 glycine:proton antiporter activity;GO:0140800 gamma-aminobutyric acid:proton antiporter activity", "go_cellular_component": "GO:0051286 cell tip;GO:0009986 cell surface;GO:0048786 presynaptic active zone;GO:0030672 synaptic vesicle membrane;GO:0060077 inhibitory synapse", "go_biological_process": "GO:0015816 glycine transport;GO:0015812 gamma-aminobutyric acid transport;GO:0051939 gamma-aminobutyric acid import;GO:0098700 neurotransmitter loading into synaptic vesicle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N354-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X6K9-1", "uniprot_id": [ { "id": "G3X6K9_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X6K9", "type": "external" } ], "mass": 172655.0, "length": 1577, "protein_name": "Adhesion G protein-coupled receptor B1", "gene_name": "ADGRB1", "organism": "Bovine", "refseq_name": "adhesion G protein-coupled receptor B1 precursor", "refseq_ac": [ { "id": "NP_001178470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178470", "type": "external" } ], "gene_names_uniprotkb": "ADGRB1", "gene_names_refseq": "ADGRB1; BAI1", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor B1; Brain-specific angiogenesis inhibitor 1", "protein_names_refseq": "adhesion G protein-coupled receptor B1 precursor; brain-specific angiogenesis inhibitor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:524070)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits angiogenesis in a CD36-dependent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0030165 PDZ domain binding;GO:0001530 lipopolysaccharide binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0014069 postsynaptic density", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007399 nervous system development;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3X6K9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X6P6-1", "uniprot_id": [ { "id": "G3X6P6_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X6P6", "type": "external" } ], "mass": 53518.0, "length": 463, "protein_name": "Calcitonin gene-related peptide type 1 receptor", "gene_name": "CALCRL", "organism": "Bovine", "refseq_name": "calcitonin gene-related peptide type 1 receptor precursor", "refseq_ac": [ { "id": "NP_001095577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095577", "type": "external" } ], "gene_names_uniprotkb": "CALCRL", "gene_names_refseq": "CALCRL", "protein_names_uniprotkb": "Calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; Calcitonin receptor-like receptor", "protein_names_refseq": "CGRP type 1 receptor; calcitonin gene-related peptide type 1 receptor precursor; calcitonin gene-related peptide type 1 receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:527140); (R-BTA-418555); (R-BTA-419812); (R-BTA-9856530)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "23849271", "class_list": "", "function": "Data indicate that adrenomedullin mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR, RAMP2 and RAMP3 were detected in cotyledonary villous and caruncular epithelial cells. Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004948 calcitonin receptor activity;GO:0001605 adrenomedullin receptor activity;GO:0001635 calcitonin gene-related peptide receptor activity;GO:1990409 adrenomedullin binding", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:1903143 adrenomedullin receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0015031 protein transport;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3X6P6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X7D2-1", "uniprot_id": [ { "id": "G3X7D2_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X7D2", "type": "external" } ], "mass": 43750.0, "length": 391, "protein_name": "Chitinase-3-like protein 1", "gene_name": "CHI3L1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CHI3L1", "gene_names_refseq": "", "protein_names_uniprotkb": "Chitinase-3-like protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6798695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0008061 chitin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0034612 response to tumor necrosis factor;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3X7D2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X8D2-1", "uniprot_id": [ { "id": "G3X8D2_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X8D2", "type": "external" } ], "mass": 52154.0, "length": 473, "protein_name": "D(1A) dopamine receptor", "gene_name": "DRD5", "organism": "Bovine", "refseq_name": "D(1B) dopamine receptor", "refseq_ac": [ { "id": "NP_001193558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193558", "type": "external" } ], "gene_names_uniprotkb": "DRD5", "gene_names_refseq": "DRD5; dbdr", "protein_names_uniprotkb": "D(1A) dopamine receptor; D(1B) dopamine receptor; D(5) dopamine receptor; Dopamine D1 receptor; Dopamine D5 receptor", "protein_names_refseq": "D(1B) dopamine receptor; D(5) dopamine receptor; D1b dopamine receptor; D5 dopamine receptor; dopamine D5 receptor; dopamine receptor type 1b", "tax_id": 9913, "disease": "", "pathway": " (bta:526221); (R-BTA-390651); (R-BTA-418555)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "26909995", "class_list": "", "function": "Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Forms heterotetramers with DRD3 to potentiate beta-arrestin recruitment and mediate locomotor activity., [UniProtKB, UniProtKB]; There were significant differences in the allelic frequencies among Bos taurus and Bos indicus breeds of different temperament for the DRD1, DRD4, and DRD5 markers. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0035240 dopamine binding;GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0005789 endoplasmic reticulum membrane;GO:0031526 brush border membrane;GO:0060170 ciliary membrane", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0008217 regulation of blood pressure;GO:0007212 G protein-coupled dopamine receptor signaling pathway;GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3X8D2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3XGD3-1", "uniprot_id": [ { "id": "G3XGD3_BOVIN", "url": "https://www.uniprot.org/uniprot/G3XGD3", "type": "external" } ], "mass": 22069.0, "length": 206, "protein_name": "Fibroblast growth factor", "gene_name": "FGF4", "organism": "Bovine", "refseq_name": "fibroblast growth factor 4 precursor", "refseq_ac": [ { "id": "NP_001035695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035695", "type": "external" } ], "gene_names_uniprotkb": "FGF4", "gene_names_refseq": "FGF4; HBGF-4; HST", "protein_names_uniprotkb": "Fibroblast growth factor; FGF", "protein_names_refseq": "fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene); fibroblast growth factor 4 precursor; heparin secretory-transforming protein; heparin-binding growth factor 4", "tax_id": 9913, "disease": "", "pathway": " (bta:618474); (R-BTA-109704); (R-BTA-1257604); (R-BTA-190322); (R-BTA-190372); (R-BTA-190373); (R-BTA-190375); (R-BTA-5654219); (R-BTA-5654221); (R-BTA-5654227); (R-BTA-5654228); (R-BTA-5654687); (R-BTA-5654688); (R-BTA-5654689); (R-BTA-5654693); (R-BTA-5654695); (R-BTA-5654699); (R-BTA-5654700); (R-BTA-5654704); (R-BTA-5654706); (R-BTA-5654710); (R-BTA-5654712); (R-BTA-5654719); (R-BTA-5654720); (R-BTA-5654726); (R-BTA-5654727); (R-BTA-5654732); (R-BTA-5654733); (R-BTA-5658623); (R-BTA-5673001); (R-BTA-6811558)", "pathway_count": 31, "publication_count": 3, "publication_id_list": "20604984;22435631;23480710", "class_list": "", "function": "Fgf4 exhibited significant hypermethylation in sperm compared with that in oocytes, [RefSeq, PubMed]; HisbFGF4, a 6x histidine-tagged bovine FGF4 (Pro(32) -Leu(206) ), was produced in Escherichia coli based on the validated nucleotide sequence and purified by heparin column chromatography. GeneRIF: Present study provides a simple method for the production of a bioactive bovine FGF4 derivative in E.coli utilizing its structural gene., [RefSeq, PubMed]; This is the first determination of the complete nucleotide sequence of the structural gene encoding bovine FGF4 in identified breeds. GeneRIF: this is the first determination of the complete nucleotide sequence of the structural gene encoding bovine FGF4 in identified breeds, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1N6H0", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0051781 positive regulation of cell division;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G3XGD3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E5I7-1", "uniprot_id": [ { "id": "G5E5I7_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E5I7", "type": "external" } ], "mass": 51603.0, "length": 471, "protein_name": "Nuclear receptor subfamily 0 group B member 1", "gene_name": "NR0B1", "organism": "Bovine", "refseq_name": "nuclear receptor subfamily 0 group B member 1", "refseq_ac": [ { "id": "NP_001192786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192786", "type": "external" } ], "gene_names_uniprotkb": "NR0B1", "gene_names_refseq": "DAX-1; NR0B1", "protein_names_uniprotkb": "Nuclear receptor subfamily 0 group B member 1; Nuclear receptor DAX-1", "protein_names_refseq": "nuclear receptor subfamily 0 group B member 1; orphan nuclear receptor DAX-1", "tax_id": 9913, "disease": "", "pathway": " (bta:281949); (R-BTA-383280)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18409030;19288253", "class_list": "", "function": "Involvement of Ad4BP/SF-1, DAX-1, and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells., [RefSeq, PubMed]; Nuclear receptor that lacks a DNA-binding domain and acts as a corepressor that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency., [UniProtKB, UniProtKB]; The decrease of Dax-1 transcription factor and the increase in histone H3 acetylation may play important roles in progesterone synthesis in luteinizing granulosa cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032448 DNA hairpin binding;GO:0003723 RNA binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0016607 nuclear speck;GO:0005840 ribosome", "go_biological_process": "GO:0007530 sex determination;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0008584 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"2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0035556 intracellular signal transduction;GO:0006355 regulation of DNA-templated transcription;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "H2XJE9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H7BWW0-1", "uniprot_id": [ { "id": "H7BWW0_BOVIN", "url": "https://www.uniprot.org/uniprot/H7BWW0", "type": "external" } ], "mass": 49651.0, "length": 445, "protein_name": "Coronin", "gene_name": "CORO1B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CORO1B", "gene_names_refseq": "", "protein_names_uniprotkb": "Coronin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0051017 actin filament bundle assembly;GO:0090135 actin filament branching;GO:0031529 ruffle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "H7BWW0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02659-1", "uniprot_id": [ { "id": "MBL2_BOVIN", "url": "https://www.uniprot.org/uniprot/O02659", "type": "external" } ], "mass": 26471.0, "length": 249, "protein_name": "Mannose-binding protein C", "gene_name": "MBL", "organism": "Bovine", "refseq_name": "mannose-binding protein C precursor", "refseq_ac": [ { "id": "NP_776532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776532", "type": "external" } ], "gene_names_uniprotkb": "MBL", "gene_names_refseq": "MBL2; MBL", "protein_names_uniprotkb": "Mannose-binding protein C; MBP-C; Mannan-binding protein", "protein_names_refseq": "MBP-C; mannan-binding protein; mannose-binding lectin (protein C) 2, soluble (opsonic defect); mannose-binding lectin-C; mannose-binding protein C precursor; mannose-binding protein C; soluble mannose-binding lectin", "tax_id": 9913, "disease": "", "pathway": " (bta:281297); (R-BTA-166662)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22771198;23096694;9074491", "class_list": "", "function": "Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity)., [UniProtKB]; Single nucleotide polymorphisms in MBL2 at exon 1 were detected using polymerase chain reaction single-strand conformation polymorphism analysis and DNA sequencing techniques in 825 Chinese Holstein cows. Publication Status: Online-Only, [RefSeq, PubMed]; The relationship between the variants of the bovine MBL2 gene and milk production traits, mastitis, serum MBL-C levels and hemolytic complement activity in both classical pathway (CH50) and alternative pathway (ACH50) in Chinese Holstein cattle, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4IFQ1", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005537 D-mannose binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005771 multivesicular body;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0006508 proteolysis;GO:0043129 surfactant homeostasis;GO:0050766 positive regulation of phagocytosis;GO:0048525 negative regulation of viral process;GO:0001867 complement activation, lectin pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O02659-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02754-1", "uniprot_id": [ { "id": "CEBPA_BOVIN", "url": "https://www.uniprot.org/uniprot/O02754", "type": "external" } ], "mass": 37218.0, "length": 353, "protein_name": "CCAAT/enhancer-binding protein alpha", "gene_name": "CEBPA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CEBPA", "gene_names_refseq": "", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein alpha; C/EBP alpha", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8904724", "class_list": "", "function": "Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung. Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage. To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex. In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4PLC3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042803 protein homodimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O02754-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02785-1", "uniprot_id": [ { "id": "SNAT_BOVIN", "url": "https://www.uniprot.org/uniprot/O02785", "type": "external" } ], "mass": 22997.0, "length": 207, "protein_name": "Serotonin N-acetyltransferase", "gene_name": "AANAT", "organism": "Bovine", "refseq_name": "serotonin N-acetyltransferase", "refseq_ac": [ { "id": "NP_803475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803475", "type": "external" } ], "gene_names_uniprotkb": "AANAT; SNAT", "gene_names_refseq": "AANAT", "protein_names_uniprotkb": "Serotonin N-acetyltransferase; 2.3.1.87; AA-NAT; Aralkylamine N-acetyltransferase; Serotonin acetylase", "protein_names_refseq": "AA-NAT; arylalkylamine N-acetyltransferase; serotonin N-acetyltransferase; serotonin acetylase", "tax_id": 9913, "disease": "", "pathway": " (bta:281583)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10036306", "class_list": "", "function": "Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin., [UniProtKB, PubMed]; The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.87", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.87", "type": "external" } ], "go_molecular_function": "GO:0004059 aralkylamine N-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007623 circadian rhythm;GO:0009416 response to light stimulus;GO:0030187 melatonin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O02785-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02786-1", "uniprot_id": [ { "id": "MSX1_BOVIN", "url": "https://www.uniprot.org/uniprot/O02786", "type": "external" } ], "mass": 31668.0, "length": 303, "protein_name": "Homeobox protein MSX-1", "gene_name": "MSX1", "organism": "Bovine", "refseq_name": "homeobox protein MSX-1", "refseq_ac": [ { "id": "NP_777223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777223", "type": "external" } ], "gene_names_uniprotkb": "MSX1", "gene_names_refseq": "MSX1", "protein_names_uniprotkb": "Homeobox protein MSX-1; Msh homeobox 1-like protein", "protein_names_refseq": "homeobox protein MSX-1; msh homeo box homolog 1; msh homeobox 1-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:286872)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20176746;7626784", "class_list": "", "function": "Acts as a transcriptional repressor (By similarity). Capable of transcription autoinactivation (By similarity). Binds to the consensus sequence 5'-C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR (By similarity). Represses transcription of myoblast differentiation factors (By similarity). Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1 (By similarity). Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells (By similarity). At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells (By similarity). May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme (By similarity). Required for BMP4 expression in dental mesenchyme cells (By similarity). Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells (By similarity). Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells (By similarity). Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells (By similarity). At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as an homeostatic regulator of the cell cycle (By similarity). Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB1 and subsequent repression of the odontoblast differentiation factors BMP2, BMP4, LEF1, ALPL and BGLAP/OCN (By similarity). Additionally, required for correct development and fusion of the palatal shelves and embryonic mandibular formation (By similarity). Plays a role in embryonic bone formation of the middle ear, skull and nasal bones (By similarity). Required for correct formation and thickness of the nail plate (By similarity). May play a role in limb-pattern formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Suppression of MSX1 affects oocyte maturation, embryo cleavage rate, and expression of numerous genes suggesting important role for MSX1 in embryo development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0034399 nuclear periphery", "go_biological_process": "GO:0043584 nose development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O02786-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02811-1", "uniprot_id": [ { "id": "PI4KA_BOVIN", "url": "https://www.uniprot.org/uniprot/O02811", "type": "external" } ], "mass": 235149.0, "length": 2102, "protein_name": "Phosphatidylinositol 4-kinase alpha", "gene_name": "PI4KA", "organism": "Bovine", "refseq_name": "phosphatidylinositol 4-kinase alpha", "refseq_ac": [ { "id": "NP_777002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777002", "type": "external" } ], "gene_names_uniprotkb": "PI4KA; PIK4CA", "gene_names_refseq": "PI4KA; PIK4CA", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase alpha; 2.7.1.67; PI4-kinase alpha; PI4K-alpha; PtdIns-4-kinase alpha", "protein_names_refseq": "PI4-kinase alpha; PI4K-alpha; phosphatidylinositol 4-kinase alpha; phosphatidylinositol 4-kinase type 3 alpha; phosphatidylinositol 4-kinase, catalytic, alpha polypeptide; ptdIns-4-kinase alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:282309)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19393038;23229899;9218477", "class_list": "", "function": "Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1MLV0", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030660 Golgi-associated vesicle membrane", "go_biological_process": "GO:0048015 phosphatidylinositol-mediated signaling;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O02811-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18737-1", "uniprot_id": [ { "id": "CACO2_BOVIN", "url": "https://www.uniprot.org/uniprot/O18737", "type": "external" } ], "mass": 52551.0, "length": 450, "protein_name": "Calcium-binding and coiled-coil domain-containing protein 2", "gene_name": "CALCOCO2", "organism": "Bovine", "refseq_name": "calcium-binding and coiled-coil domain-containing protein 2", "refseq_ac": [ { "id": "NP_776825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776825", "type": "external" } ], "gene_names_uniprotkb": "CALCOCO2; NDP52", "gene_names_refseq": "CALCOCO2; NDP52", "protein_names_uniprotkb": "Calcium-binding and coiled-coil domain-containing protein 2; Antigen nuclear dot 52 kDa protein; Nuclear domain 10 protein 52; Nuclear domain 10 protein NDP52; Nuclear dot protein 52", "protein_names_refseq": "antigen nuclear dot 52 kDa protein; calcium-binding and coiled-coil domain-containing protein 2; nuclear domain 10 protein 52; nuclear domain 10 protein NDP52; nuclear dot protein 52", "tax_id": 9913, "disease": "", "pathway": " (bta:281942)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005856 cytoskeleton;GO:0048471 perinuclear region of cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome", "go_biological_process": "GO:1901098 positive regulation of autophagosome maturation;GO:0098792 xenophagy;GO:0034341 response to type II interferon;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O18737-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18767-1", "uniprot_id": [ { "id": "MMP20_BOVIN", "url": "https://www.uniprot.org/uniprot/O18767", "type": "external" } ], "mass": 53781.0, "length": 481, "protein_name": "Matrix metalloproteinase-20", "gene_name": "MMP20", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MMP20", "gene_names_refseq": "", "protein_names_uniprotkb": "Matrix metalloproteinase-20; 3.4.24.-; Enamel metalloproteinase; Enamelysin; MMP-20", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281916)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10515200;9541246", "class_list": "", "function": "Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Ser-|-Phe-361' site., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process;GO:0097186 amelogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O18767-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18784-1", "uniprot_id": [ { "id": "TRPC1_BOVIN", "url": "https://www.uniprot.org/uniprot/O18784", "type": "external" } ], "mass": 91339.0, "length": 793, "protein_name": "Short transient receptor potential channel 1", "gene_name": "TRPC1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TRPC1; TRP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Short transient receptor potential channel 1; TRP-1; Transient receptor protein 1; TrpC1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:282100)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9357995", "class_list": "", "function": "Forms a receptor-activated non-selective calcium permeant cation channel. Forms a heteromeric ion channel with TRPC4 or TRPC5 that has reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel (By similarity). Also permeable to monovalent ions including sodium, lithium and cesium ions (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O18785", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0046872 metal ion binding;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O18784-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18870-1", "uniprot_id": [ { "id": "SMN_BOVIN", "url": "https://www.uniprot.org/uniprot/O18870", "type": "external" } ], "mass": 31327.0, "length": 287, "protein_name": "Survival motor neuron protein", "gene_name": "SMN1", "organism": "Bovine", "refseq_name": "survival motor neuron protein", "refseq_ac": [ { "id": "NP_783632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783632", "type": "external" } ], "gene_names_uniprotkb": "SMN1; SMN", "gene_names_refseq": "SMN1; SMN2; SMN", "protein_names_uniprotkb": "Survival motor neuron protein", "protein_names_refseq": "survival motor neuron protein; survival of motor neuron 1, telomeric", "tax_id": 9913, "disease": "", "pathway": " (bta:281492); (R-BTA-191859)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12776181;26724723;9800343;9925919", "class_list": "", "function": "Data show that the coding sequence of survival of motor neuron 2 (SMN2) differs from that of survival motor neuron 1 (SMN1) by a single nucleotide (c.840C>T) at codon 280 in exon 7. Publication Status: Online-Only, [RefSeq, PubMed]; SMN protein functions in cytoplasmic Sm-core assembly and in the recruitment of the snRNA cap hypermethylase, [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O46481;O62700;Q9TSJ9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0007409 axonogenesis;GO:0000387 spliceosomal snRNP assembly;GO:0006353 DNA-templated transcription termination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O18870-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O19110-1", "uniprot_id": [ { "id": "TSPY1_BOVIN", "url": "https://www.uniprot.org/uniprot/O19110", "type": "external" } ], "mass": 36619.0, "length": 317, "protein_name": "Testis-specific Y-encoded protein 1", "gene_name": "TSPY1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TSPY1; TSPY", "gene_names_refseq": "", "protein_names_uniprotkb": "Testis-specific Y-encoded protein 1; bTSPY", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "8244389;9195993", "class_list": "", "function": "May be involved in sperm differentiation and proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O19106;O19107;O19109;O19185", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006334 nucleosome assembly;GO:0007506 gonadal mesoderm development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O19110-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O19182-1", "uniprot_id": [ { "id": "KCNJ2_BOVIN", "url": "https://www.uniprot.org/uniprot/O19182", "type": "external" } ], "mass": 48286.0, "length": 427, "protein_name": "Inward rectifier potassium channel 2", "gene_name": "KCNJ2", "organism": "Bovine", "refseq_name": "inward rectifier potassium channel 2", "refseq_ac": [ { "id": "NP_776798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776798", "type": "external" } ], "gene_names_uniprotkb": "KCNJ2; IRK1", "gene_names_refseq": "KCNJ2", "protein_names_uniprotkb": "Inward rectifier potassium channel 2; BIK; IRK-1; Inward rectifier K(+) channel Kir2.1; Potassium channel, inwardly rectifying subfamily J member 2", "protein_names_refseq": "BIK; IRK-1; inward rectifier K(+) channel Kir2.1; inward rectifier potassium channel 2; potassium channel, inwardly rectifying subfamily J member 2; potassium voltage-gated channel subfamily J member 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281883); (R-BTA-1296041); (R-BTA-1296053); (R-BTA-5576886); (R-BTA-997272)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10967048;12562923;21726538;27235552;9202161;9533862", "class_list": "", "function": "Hypoxic stress up-regulates Kir2.1 expression and facilitates cell proliferation in brain capillary endothelial cells., [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (PubMed:9202161, PubMed:10967048). Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Kir2.1 may mediate native Kir currents responsible for setting resting membrane potential in bovine parotid cells and might be, at least in part, involved in spontaneous secretion in ruminant parotid glands. Erratum:[J Physiol. 2003 Mar 15;547(Pt 3):995], [RefSeq, PubMed]; The present results suggest that the up-regulation of K(ir)2.1 is, at least in part, responsible for cell death of brain capillary endothelial cells induced by a variety of cellular stresses, particularly ER stress, under pathological conditions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex;GO:0030315 T-tubule", "go_biological_process": "GO:0014861 regulation of skeletal muscle contraction via regulation of action potential;GO:0051289 protein homotetramerization;GO:0060306 regulation of membrane repolarization;GO:0086091 regulation of heart rate by cardiac conduction;GO:0006813 potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O19182-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46406-1", "uniprot_id": [ { "id": "AOCY_BOVIN", "url": "https://www.uniprot.org/uniprot/O46406", "type": "external" } ], "mass": 84883.0, "length": 762, "protein_name": "Primary amine oxidase, lung isozyme", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Primary amine oxidase, lung isozyme; 1.4.3.21; Amine oxidase [copper-containing]; BOLAO; Copper amine oxidase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9492300", "class_list": "", "function": "", "predicted_glycosites": 8, "predicted_n_glycosites": 5, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "1.4.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.21", "type": "external" }, { "id": "1.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.4", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005507 copper ion binding;GO:0008131 primary methylamine oxidase activity;GO:0048038 quinone binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0009308 amine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O46406-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O62768-1", "uniprot_id": [ { "id": "TRXR1_BOVIN", "url": "https://www.uniprot.org/uniprot/O62768", "type": "external" } ], "mass": 54770.0, "length": 499, "protein_name": "Thioredoxin reductase 1, cytoplasmic", "gene_name": "TXNRD1", "organism": "Bovine", "refseq_name": "thioredoxin reductase 1, cytoplasmic", "refseq_ac": [ { "id": "NP_777050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777050", "type": "external" } ], "gene_names_uniprotkb": "TXNRD1", "gene_names_refseq": "TXNRD1", "protein_names_uniprotkb": "Thioredoxin reductase 1, cytoplasmic; 1.11.1.2; 1.8.1.9; Peroxidase TXNRD1; TR; Thioredoxin reductase TR1", "protein_names_refseq": "TR; peroxidase TXNRD1; thioredoxin reductase 1, cytoplasmic; thioredoxin reductase TR1", "tax_id": 9913, "disease": "", "pathway": " (bta:282388); (R-BTA-3299685); (R-BTA-499943); (R-BTA-5263617); (R-BTA-5628897)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "14584040;16209660", "class_list": "", "function": "Data provide evidence for the involvement of the Trx/TrxR system, in the regulation of haem oxygenase-1 expression in aortic endothelial cells during pro-oxidant challenge, [RefSeq, PubMed]; Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. A selenocysteine residue at the C-terminal active site is essential for catalysis. Also has reductase activity on hydrogen peroxide (H2O2)., [UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, May 2017]., [RefSeq]; These results suggest that thioredoxin reductase may act as a positive regulator of NF-kappa B and may play an important role in the cellular inflammatory response., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.9", "type": "external" }, { "id": "1.11.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.2", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity;GO:0042802 identical protein binding;GO:0071949 FAD binding;GO:0050137 NADPH peroxidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O62768-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O75601-1", "uniprot_id": [ { "id": "CASPD_BOVIN", "url": "https://www.uniprot.org/uniprot/O75601", "type": "external" } ], "mass": 43012.0, "length": 377, "protein_name": "Caspase-13", "gene_name": "CASP13", "organism": "Bovine", "refseq_name": "caspase-4", "refseq_ac": [ { "id": "NP_788811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788811", "type": "external" } ], "gene_names_uniprotkb": "CASP13", "gene_names_refseq": "CASP13; CASP4", "protein_names_uniprotkb": "Caspase-13; 3.4.22.-; CASP-13; ERICE; Evolutionary related interleukin-1-beta-converting enzyme", "protein_names_refseq": "CASP-13; CASP-4; ERICE; caspase 4, apoptosis-related cysteine protease; caspase-13; caspase-4; evolutionary related interleukin-1-beta-converting enzyme", "tax_id": 9913, "disease": "", "pathway": " (bta:338039); (R-BTA-5620971); (R-BTA-9948001); (R-BTA-9948011); (R-BTA-9960519); (R-BTA-9960525)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "11478774;9624166", "class_list": "", "function": "Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0072558 NLRP1 inflammasome complex", "go_biological_process": "GO:0006508 proteolysis;GO:0006915 apoptotic process;GO:0050729 positive regulation of inflammatory response;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O75601-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77700-1", "uniprot_id": [ { "id": "ADA2B_BOVIN", "url": "https://www.uniprot.org/uniprot/O77700", "type": "external" } ], "mass": 42840.0, "length": 392, "protein_name": "Alpha-2B adrenergic receptor", "gene_name": "ADRA2B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ADRA2B", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-2B adrenergic receptor; Alpha-2B adrenoceptor; Alpha-2B adrenoreceptor; Alpha-2BAR", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9667998", "class_list": "", "function": "Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004938 alpha2-adrenergic receptor activity;GO:0051379 epinephrine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0019229 regulation of vasoconstriction;GO:0030168 platelet activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O77700-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77774-1", "uniprot_id": [ { "id": "NCF1_BOVIN", "url": "https://www.uniprot.org/uniprot/O77774", "type": "external" } ], "mass": 45346.0, "length": 392, "protein_name": "Neutrophil cytosol factor 1", "gene_name": "NCF1", "organism": "Bovine", "refseq_name": "neutrophil cytosol factor 1", "refseq_ac": [ { "id": "NP_776544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776544", "type": "external" } ], "gene_names_uniprotkb": "NCF1", "gene_names_refseq": "NCF1", "protein_names_uniprotkb": "Neutrophil cytosol factor 1; 47 kDa neutrophil oxidase factor; NCF-1; NCF-47K; Neutrophil NADPH oxidase factor 1; p47-phox", "protein_names_refseq": "47 kDa neutrophil oxidase factor; NCF-1; NCF-47K; neutrophil NADPH oxidase factor 1; neutrophil cytosol factor 1; neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1); neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1); p47-phox", "tax_id": 9913, "disease": "", "pathway": " (bta:281345)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10647999;16305752;19168729;25946326;26826128", "class_list": "", "function": "A p47(phox) and Src kinase activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C., [RefSeq, PubMed]; Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress., [RefSeq, PubMed]; Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:10647999). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity)., [UniProtKB, UniProtKB, PubMed]; Two novel splice variants designed as NCF1-TV1 (retained intron 6) and NCF1-TV2 (retained part of intron 8)encoding two putative truncated proteins (239AA and 283AA). Two splice variants were up-regulated in the mastitis-infected cows' mammary tissues, blood and neutrophils compared with these of healthy cows. Erratum:[Microbiol Res. 2015 Dec;181():120], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5E9R8", "ec_number_list": [], "go_molecular_function": "GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0035091 phosphatidylinositol binding;GO:0016176 superoxide-generating NADPH oxidase activator activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0045730 respiratory burst;GO:0042554 superoxide anion generation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O77774-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77775-1", "uniprot_id": [ { "id": "NCF2_BOVIN", "url": "https://www.uniprot.org/uniprot/O77775", "type": "external" } ], "mass": 59663.0, "length": 527, "protein_name": "Neutrophil cytosol factor 2", "gene_name": "NCF2", "organism": "Bovine", "refseq_name": "neutrophil cytosol factor 2", "refseq_ac": [ { "id": "NP_776545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776545", "type": "external" } ], "gene_names_uniprotkb": "NCF2", "gene_names_refseq": "NCF2", "protein_names_uniprotkb": "Neutrophil cytosol factor 2; 67 kDa neutrophil oxidase factor; NCF-2; Neutrophil NADPH oxidase factor 2; p67-phox", "protein_names_refseq": "67 kDa neutrophil oxidase factor; NCF-2; neutrophil NADPH oxidase factor 2; neutrophil cytosol factor 2; neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2); p67-phox", "tax_id": 9913, "disease": "", "pathway": " (bta:281346)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10647999", "class_list": "", "function": "Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (By similarity). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016176 superoxide-generating NADPH oxidase activator activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006909 phagocytosis;GO:0045730 respiratory burst;GO:0042554 superoxide anion generation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O77775-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77780-1", "uniprot_id": [ { "id": "ADAM2_BOVIN", "url": "https://www.uniprot.org/uniprot/O77780", "type": "external" } ], "mass": 83150.0, "length": 745, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 2", "gene_name": "ADAM2", "organism": "Bovine", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 2 precursor", "refseq_ac": [ { "id": "NP_776653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776653", "type": "external" } ], "gene_names_uniprotkb": "ADAM2; FTNB", "gene_names_refseq": "ADAM2", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 2; ADAM 2; Fertilin subunit beta; PH-30; PH30-beta; PH30", "protein_names_refseq": "ADAM 2; ADAM metallopeptidase domain 2 (fertilin beta); PH-30; PH30-beta; PH30; a disintegrin and metalloproteinase domain 2 (fertilin beta); disintegrin and metalloproteinase domain-containing protein 2 precursor; disintegrin and metalloproteinase domain-containing protein 2; fertilin subunit beta", "tax_id": 9913, "disease": "", "pathway": " (bta:281599)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9160725", "class_list": "", "function": "Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity)., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0007339 binding of sperm to zona pellucida;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O77780-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97552-1", "uniprot_id": [ { "id": "PO5F1_BOVIN", "url": "https://www.uniprot.org/uniprot/O97552", "type": "external" } ], "mass": 38289.0, "length": 360, "protein_name": "POU domain, class 5, transcription factor 1", "gene_name": "POU5F1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "POU5F1; OCT3", "gene_names_refseq": "", "protein_names_uniprotkb": "POU domain, class 5, transcription factor 1; OTF-3; Oct-3; Octamer-binding protein 3; Octamer-binding transcription factor 3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10208969", "class_list": "", "function": "Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O97552-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97902-1", "uniprot_id": [ { "id": "ASAP1_BOVIN", "url": "https://www.uniprot.org/uniprot/O97902", "type": "external" } ], "mass": 125382.0, "length": 1129, "protein_name": "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1", "gene_name": "ASAP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ASAP1; DDEF1", "gene_names_refseq": "", "protein_names_uniprotkb": "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; DEF-1; Development and differentiation-enhancing factor 1; Differentiation-enhancing factor 1; PIP2-dependent ARF1 GAP", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:327705)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10022919;9819391", "class_list": "", "function": "Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0002102 podosome;GO:0034451 centriolar satellite", "go_biological_process": "GO:0060271 cilium assembly;GO:1903527 positive regulation of membrane tubulation;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O97902-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00376-1", "uniprot_id": [ { "id": "DYR_BOVIN", "url": "https://www.uniprot.org/uniprot/P00376", "type": "external" } ], "mass": 21604.0, "length": 187, "protein_name": "Dihydrofolate reductase", "gene_name": "DHFR", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DHFR", "gene_names_refseq": "", "protein_names_uniprotkb": "Dihydrofolate reductase; 1.5.1.3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:508809)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7115669", "class_list": "", "function": "Catalyzes the reduction of 7,8-dihydrofolate (DHF) to 5,6,7,8-tetrahydrofolate in a NADPH-dependent manner. Key enzyme in folate metabolism. Contributes to the nuclear and mitochondrial de novo thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29RI1", "ec_number_list": [ { "id": "1.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.3", "type": "external" } ], "go_molecular_function": "GO:0004146 dihydrofolate reductase activity;GO:0003729 mRNA binding;GO:0050661 NADP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0006730 one-carbon metabolic process;GO:0046655 folic acid metabolic process;GO:0031427 response to methotrexate;GO:0046653 tetrahydrofolate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P00376-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00792-1", "uniprot_id": [ { "id": "PEPA_BOVIN", "url": "https://www.uniprot.org/uniprot/P00792", "type": "external" } ], "mass": 40003.0, "length": 372, "protein_name": "Pepsin A", "gene_name": "PGA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PGA", "gene_names_refseq": "", "protein_names_uniprotkb": "Pepsin A; 3.4.23.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:414350)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15128507;4603017;776669", "class_list": "", "function": "Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6VRA9", "ec_number_list": [], "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P00792-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01017-1", "uniprot_id": [ { "id": "ANGT_BOVIN", "url": "https://www.uniprot.org/uniprot/P01017", "type": "external" } ], "mass": 51424.0, "length": 476, "protein_name": "Angiotensinogen", "gene_name": "AGT", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AGT; SERPINA8", "gene_names_refseq": "", "protein_names_uniprotkb": "Angiotensinogen; Ang III; Ang II; Ang IV; Ang I; Angiotensin 1-10; Angiotensin 1-8; Angiotensin 2-8; Angiotensin 3-8; Angiotensin III; Angiotensin II; Angiotensin IV; Angiotensin I; Des-Asp[1]-angiotensin II; Serpin A8", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2022377); (R-BTA-375276); (R-BTA-416476); (R-BTA-418594)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "13403900", "class_list": "", "function": "Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Is a ligand for the G protein-coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets., [UniProtKB, UniProtKB]; Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets., [UniProtKB, UniProtKB]; Stimulates aldosterone release., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A3Q1LGY9", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin;GO:0007340 acrosome reaction;GO:0038166 angiotensin-activated signaling pathway;GO:0042310 vasoconstriction;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01017-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01030-1", "uniprot_id": [ { "id": "CO4_BOVIN", "url": "https://www.uniprot.org/uniprot/P01030", "type": "external" } ], "mass": 192797.0, "length": 1741, "protein_name": "Complement C4", "gene_name": "C4", "organism": "Bovine", "refseq_name": "complement C4 precursor", "refseq_ac": [ { "id": "NP_001159957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159957", "type": "external" } ], "gene_names_uniprotkb": "C4", "gene_names_refseq": "C4A; C4", "protein_names_uniprotkb": "Complement C4", "protein_names_refseq": "complement C4 precursor; complement C4; complement component C4", "tax_id": 9913, "disease": "", "pathway": " (bta:280678)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19393038;22155013;22653646;6760852", "class_list": "", "function": "3 SNPs and association with milk performance traits and CH50 assay, [RefSeq, PubMed]; Non-enzymatic component of C3 and C5 convertases. Generated following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway), it covalently attaches to the surface of pathogens, where it acts as an opsonin that marks the surface of antigens for removal. It then recruits the serine protease complement C2b to form the C3 and C5 convertases, which cleave and activate C3 and C5, respectively, the next components of the complement pathways. Complement C4b-A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while complement C4b-B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens., [UniProtKB, UniProtKB]; Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system., [UniProtKB, UniProtKB]; Putative humoral mediator released following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway). While it is strongly similar to anaphylatoxins, its role is unclear. Was reported to act as a mediator of local inflammatory process; however these effects were probably due to contamination with C3a and/C5a anaphylatoxins in biological assays., [UniProtKB, UniProtKB]; The C4A-complete transcript is the main transcript under normal physiological conditions, while C4A-AS is augmented when mastitis develops. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q27992;Q27993", "ec_number_list": [], "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity;GO:0003823 antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0006954 inflammatory response;GO:0001867 complement activation, lectin pathway;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation;GO:0160257 complement activation, GZMK pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P01030-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01352-1", "uniprot_id": [ { "id": "GAST_BOVIN", "url": "https://www.uniprot.org/uniprot/P01352", "type": "external" } ], "mass": 11573.0, "length": 104, "protein_name": "Gastrin", "gene_name": "GAST", "organism": "Bovine", "refseq_name": "gastrin precursor", "refseq_ac": [ { "id": "NP_776340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776340", "type": "external" } ], "gene_names_uniprotkb": "GAST; GAS", "gene_names_refseq": "GAST; GAS", "protein_names_uniprotkb": "Gastrin; G34; Gastrin-34", "protein_names_refseq": "gastrin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280800); (R-BTA-416476); (R-BTA-881907)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1773057;2608050;5665711", "class_list": "", "function": "Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q28114", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032094 response to food", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P01352-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01576-1", "uniprot_id": [ { "id": "IFNB2_BOVIN", "url": "https://www.uniprot.org/uniprot/P01576", "type": "external" } ], "mass": 22319.0, "length": 186, "protein_name": "Interferon beta-2", "gene_name": "IFNB2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IFNB2", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon beta-2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:517016)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has antiviral, antibacterial and anticancer activities., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0071359 cellular response to dsRNA;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P01576-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01577-1", "uniprot_id": [ { "id": "IFNB3_BOVIN", "url": "https://www.uniprot.org/uniprot/P01577", "type": "external" } ], "mass": 22060.0, "length": 186, "protein_name": "Interferon beta-3", "gene_name": "IFNB3", "organism": "Bovine", "refseq_name": "interferon beta-3 precursor", "refseq_ac": [ { "id": "NP_001107769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107769", "type": "external" } ], "gene_names_uniprotkb": "IFNB3", "gene_names_refseq": "IF1DA2; IFNB3", "protein_names_uniprotkb": "Interferon beta-3", "protein_names_refseq": "interferon 1DA2; interferon beta-3 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:618946)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22902481", "class_list": "", "function": "Has antiviral, antibacterial and anticancer activities., [UniProtKB]; The authors provide evidence that ICP27 protein encoded by bovine herpesvirus type 1, a viral early protein that shuttles between the nucleus and cytoplasm inhibits transcriptional activity of two bovine IFN-beta gene promoters (IFN-beta1 and IFN-beta3)., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0071359 cellular response to dsRNA;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01577-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01578-1", "uniprot_id": [ { "id": "IFNB_BOVIN", "url": "https://www.uniprot.org/uniprot/P01578", "type": "external" } ], "mass": 22195.0, "length": 186, "protein_name": "Interferon beta", "gene_name": "IFNB1", "organism": "Bovine", "refseq_name": "interferon beta precursor", "refseq_ac": [ { "id": "NP_776775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776775", "type": "external" } ], "gene_names_uniprotkb": "IFNB1", "gene_names_refseq": "IFNB1; IFNb", "protein_names_uniprotkb": "Interferon beta; IFN-beta", "protein_names_refseq": "IFN-beta; interferon beta precursor; interferon beta-1", "tax_id": 9913, "disease": "", "pathway": " (bta:281845)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12857912;21316405;21689696;22902481;26418342;28432927", "class_list": "", "function": "BVDV2-E significantly increased IFN-beta activity compared to BVDV2-wt., [RefSeq, PubMed]; Recombinant bovine respiratory syncytial virus lacking the NS proteins, and those lacking NS2 in particular, are strong inducers of IFN-alpha/beta in bovine nasal fibroblasts and bronchoalveolar macrophages., [RefSeq, PubMed]; The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 degradation., [RefSeq, PubMed]; The authors provide evidence that ICP27 protein encoded by bovine herpesvirus type 1, a viral early protein that shuttles between the nucleus and cytoplasm inhibits transcriptional activity of two bovine IFN-beta gene promoters (IFN-beta1 and IFN-beta3)., [RefSeq, PubMed]; The data confirm the involvement of EHMT2 in the epigenetic regulation of IFN-b and demonstrate the activation of a general antiviral state after EHMT2 inhibition., [RefSeq, PubMed]; These studies provide evidence that virus infection differentially stimulates expression of the three bovine IFN-beta genes., [RefSeq, PubMed]; Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0071359 cellular response to dsRNA;GO:0051607 defense response to virus;GO:0070050 neuron cellular homeostasis;GO:0060337 type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P01578-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02081-1", "uniprot_id": [ { "id": "HBBF_BOVIN", "url": "https://www.uniprot.org/uniprot/P02081", "type": "external" } ], "mass": 15859.0, "length": 145, "protein_name": "Hemoglobin fetal subunit beta", "gene_name": "", "organism": "Bovine", "refseq_name": "hemoglobin fetal subunit beta", "refseq_ac": [ { "id": "NP_001014902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014902", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "HBG", "protein_names_uniprotkb": "Hemoglobin fetal subunit beta; Beta-globin, fetal; Hemoglobin beta chain, fetal; Hemoglobin gamma chain", "protein_names_refseq": "beta-globin, fetal; globin, gamma; hemoglobin beta chain, fetal; hemoglobin fetal subunit beta; hemoglobin gamma chain; hemoglobin, gamma 2", "tax_id": 9913, "disease": "", "pathway": " (bta:511735)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10958351;30573663;5958205;6322113", "class_list": "", "function": "Involved in oxygen transport from the lung to the various peripheral tissues., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SX09", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P02081-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02313-1", "uniprot_id": [ { "id": "HMGN2_BOVIN", "url": "https://www.uniprot.org/uniprot/P02313", "type": "external" } ], "mass": 9380.0, "length": 90, "protein_name": "Non-histone chromosomal protein HMG-17", "gene_name": "HMGN2", "organism": "Bovine", "refseq_name": "non-histone chromosomal protein HMG-17", "refseq_ac": [ { "id": "NP_001092415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092415", "type": "external" } ], "gene_names_uniprotkb": "HMGN2; HMG17", "gene_names_refseq": "HMGN2", "protein_names_uniprotkb": "Non-histone chromosomal protein HMG-17; High mobility group nucleosome-binding domain-containing protein 2", "protein_names_refseq": "high mobility group nucleosome-binding domain-containing protein 2; non-histone chromosomal protein HMG-17; nonhistone chromosomal protein HMG-17", "tax_id": 9913, "disease": "", "pathway": " (bta:512161)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17712799;330164;793593", "class_list": "", "function": "Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity)., [UniProtKB]; Rate of positive nuclei in early-cleaved embryos from small-versus large-follicles is similar for HMGN2 after parthenogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJU3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003676 nucleic acid binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P02313-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02526-1", "uniprot_id": [ { "id": "CRGB_BOVIN", "url": "https://www.uniprot.org/uniprot/P02526", "type": "external" } ], "mass": 21097.0, "length": 175, "protein_name": "Gamma-crystallin B", "gene_name": "CRYGB", "organism": "Bovine", "refseq_name": "gamma-crystallin B", "refseq_ac": [ { "id": "NP_001013612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013612", "type": "external" } ], "gene_names_uniprotkb": "CRYGB", "gene_names_refseq": "CRYGB", "protein_names_uniprotkb": "Gamma-crystallin B; Gamma-B-crystallin; Gamma-crystallin II", "protein_names_refseq": "gamma-B-crystallin; gamma-crystallin B; gamma-crystallin II; gammaB-crystallin", "tax_id": 9913, "disease": "", "pathway": " (bta:281720)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "15299528;15299624;18509547;26849192;3255364;3364984;3606621;6092016;6631960;7464942;8954545;9541393;9642083", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]; Gamma-B crystallin synonymous codons provide a secondary code for protein folding in the cell., [RefSeq, PubMed]; The results are consistent with the hypothesis that short-range, weak, attractive interactions between alpha- and gamma-crystallins are necessary for maximum transparency of the lens. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 1, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TJU8", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P02526-1", "record_type": "protein", "filter_code": "0000000.0010101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03929-1", "uniprot_id": [ { "id": "ATP8_BOVIN", "url": "https://www.uniprot.org/uniprot/P03929", "type": "external" } ], "mass": 7937.0, "length": 66, "protein_name": "ATP synthase F(0) complex subunit 8", "gene_name": "MT-ATP8", "organism": "Bovine", "refseq_name": "ATP synthase F0 subunit 8", "refseq_ac": [ { "id": "YP_209209", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209209", "type": "external" } ], "gene_names_uniprotkb": "MT-ATP8; ATP8; ATPASE8; MTATP8", "gene_names_refseq": "ATP8", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit 8; A6L; F-ATPase subunit 8", "protein_names_refseq": "ATP synthase F0 subunit 8", "tax_id": 9913, "disease": "", "pathway": " (bta:3283881); (R-BTA-163210); (R-BTA-5419276); (R-BTA-8949613)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "17570365;1827992;25851905;2875870;7120390", "class_list": "", "function": "Subunit 8, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P03929-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03972-1", "uniprot_id": [ { "id": "AMH_BOVIN", "url": "https://www.uniprot.org/uniprot/P03972", "type": "external" } ], "mass": 60624.0, "length": 575, "protein_name": "Anti-Muellerian hormone", "gene_name": "AMH", "organism": "Bovine", "refseq_name": "anti-Muellerian hormone precursor", "refseq_ac": [ { "id": "NP_776315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776315", "type": "external" } ], "gene_names_uniprotkb": "AMH", "gene_names_refseq": "AMH", "protein_names_uniprotkb": "Anti-Muellerian hormone; AMH; MIS; Muellerian-inhibiting factor; Muellerian-inhibiting substance", "protein_names_refseq": "MIS; anti-Muellerian hormone precursor; anti-Muellerian hormone; muellerian-inhibiting factor; muellerian-inhibiting substance", "tax_id": 9913, "disease": "", "pathway": " (bta:280718)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "18448844;19714502;21076084;28333275;30554590;32169754;3754790;37902253;38366707", "class_list": "", "function": "AMH expression is modulated by androgens in bovine granulosa cells from small follicles., [RefSeq, PubMed]; Anti-Mullerian hormone and its receptor are detected in most gonadotropin-releasing-hormone cell bodies and fibers in heifer brains., [RefSeq, PubMed]; Anti-Mullerian hormone inhibits activation and growth of bovine ovarian follicles in vitro and is localized to growing follicles., [RefSeq, PubMed]; Anti-Mullerian hormone: A novel biomarker for detecting bovine freemartinism., [RefSeq, PubMed]; Association between maternal growth in the pre-conception and early gestational period of nulliparous dairy heifers with anti-Mullerian hormone in their female offspring., [RefSeq, PubMed]; Bovine gonadotrophs express AMH and this AMH expression may be breed-dependent., [RefSeq, PubMed]; Intrafollicular AMH was not a marker of cystic development in the cow, but low AMH concentrations in cysts were associated with luteinization., [RefSeq, PubMed]; Regulation of anti-Mullerian hormone production in the cow., [RefSeq, PubMed]; The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions (By similarity). Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction (By similarity). Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation (By similarity). In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (By similarity). Also plays a role in Leydig cell differentiation and function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005160 transforming growth factor beta receptor binding;GO:0008083 growth factor activity;GO:0005114 type II transforming growth factor beta receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:2000355 negative regulation of ovarian follicle development;GO:0001541 ovarian follicle development;GO:0001880 Mullerian duct regression;GO:0033327 Leydig cell differentiation;GO:0007506 gonadal mesoderm development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P03972-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04651-1", "uniprot_id": [ { "id": "LSHB_BOVIN", "url": "https://www.uniprot.org/uniprot/P04651", "type": "external" } ], "mass": 15202.0, "length": 141, "protein_name": "Lutropin subunit beta", "gene_name": "LHB", "organism": "Bovine", "refseq_name": "lutropin subunit beta precursor", "refseq_ac": [ { "id": "NP_776355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776355", "type": "external" } ], "gene_names_uniprotkb": "LHB", "gene_names_refseq": "LHB", "protein_names_uniprotkb": "Lutropin subunit beta; LH-B; LSH-B; LSH-beta; Luteinizing hormone subunit beta; Lutropin beta chain", "protein_names_refseq": "LH-B; LSH-B; LSH-beta; luteinizing hormone beta polypeptide; luteinizing hormone beta subunit; lutropin beta chain; lutropin subunit beta precursor; lutropin subunit beta", "tax_id": 9913, "disease": "", "pathway": " (bta:280839); (R-BTA-193048); (R-BTA-193993); (R-BTA-209822); (R-BTA-375281); (R-BTA-418555); (R-BTA-8866910); (R-BTA-975578)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "2946684;2987241;2999125;3838746;4770795", "class_list": "", "function": "Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 17, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001541 ovarian follicle development;GO:0042700 luteinizing hormone signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P04651-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04836-1", "uniprot_id": [ { "id": "CBPE_BOVIN", "url": "https://www.uniprot.org/uniprot/P04836", "type": "external" } ], "mass": 53309.0, "length": 475, "protein_name": "Carboxypeptidase E", "gene_name": "CPE", "organism": "Bovine", "refseq_name": "carboxypeptidase E precursor", "refseq_ac": [ { "id": "NP_776328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776328", "type": "external" } ], "gene_names_uniprotkb": "CPE", "gene_names_refseq": "CPE; CPH", "protein_names_uniprotkb": "Carboxypeptidase E; 3.4.17.10; CPE; CPH; Carboxypeptidase H; Enkephalin convertase; Prohormone-processing carboxypeptidase", "protein_names_refseq": "carboxypeptidase E precursor; carboxypeptidase H; enkephalin convertase; prohormone-processing carboxypeptidase", "tax_id": 9913, "disease": "", "pathway": " (bta:280753)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2396993;3020433", "class_list": "", "function": "Sorting receptor that directs prohormones to the regulated secretory pathway. Also acts as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A5PJN4;Q52S88;Q6YI55", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0050839 cell adhesion molecule binding;GO:0004181 metallocarboxypeptidase activity;GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0030658 transport vesicle membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0016485 protein processing;GO:0006518 peptide metabolic process;GO:0016055 Wnt signaling pathway;GO:0072657 protein localization to membrane;GO:0003214 cardiac left ventricle morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P04836-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05363-1", "uniprot_id": [ { "id": "NK2R_BOVIN", "url": "https://www.uniprot.org/uniprot/P05363", "type": "external" } ], "mass": 43069.0, "length": 384, "protein_name": "Substance-K receptor", "gene_name": "TACR2", "organism": "Bovine", "refseq_name": "substance-K receptor", "refseq_ac": [ { "id": "NP_776894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776894", "type": "external" } ], "gene_names_uniprotkb": "TACR2; TAC2R", "gene_names_refseq": "TACR2", "protein_names_uniprotkb": "Substance-K receptor; NK-2 receptor; NK-2R; Neurokinin A receptor; SKR; Tachykinin receptor 2", "protein_names_refseq": "NK-2 receptor; NK-2R; SKR; neurokinin 2 receptor; neurokinin A receptor; substance-K receptor; tachykinin 2 receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:282088); (R-BTA-380095); (R-BTA-416476)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "2823146", "class_list": "", "function": "Receptor for the tachykinin substance K (neurokinin A), also able to bind and respond to tachynins substance P and neurokinin B/neuromedin-K. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P (By similarity). Substance K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (By similarity). Substance K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016497 substance K receptor activity", "go_cellular_component": "GO:0061827 sperm head;GO:0005886 plasma membrane;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:1902093 positive regulation of flagellated sperm motility;GO:0070472 regulation of uterine smooth muscle contraction;GO:0007209 phospholipase C-activating tachykinin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P05363-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05402-1", "uniprot_id": [ { "id": "PLRP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P05402", "type": "external" } ], "mass": 27719.0, "length": 238, "protein_name": "Placental prolactin-related protein 1", "gene_name": "PRP1", "organism": "Bovine", "refseq_name": "placental prolactin-related protein 1 precursor", "refseq_ac": [ { "id": "NP_776584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776584", "type": "external" } ], "gene_names_uniprotkb": "PRP1", "gene_names_refseq": "GHE3; PRP1", "protein_names_uniprotkb": "Placental prolactin-related protein 1; PRC-I; bPRCI", "protein_names_refseq": "PRC-I; bPRCI; growth hormone E3; placental prolactin-related protein 1 precursor; placental prolactin-related protein 1; prolactin-related protein 12", "tax_id": 9913, "disease": "", "pathway": " (bta:281429)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12649735;17071780;18252946;20298748;2721368;3475696", "class_list": "", "function": "Data show that cleaved PRP1 proliferates endothelial cells in vitro, and suggest that endothelial cell proliferation activity of cleaved PRP1 may be shared in specific bovine placentomal angiogenesis., [RefSeq, PubMed]; Interaction of bPRP-I with type IV collagen suggests that bPRP-I accumulates in extracellular matrix where it likely acts on cells traversing the bovine placentome., [RefSeq, PubMed]; Placental prolactin-related protein-I is identified as a major target of bovine binucleate trophoblast giant cell lectin binding, [RefSeq, PubMed]; Placental prolactin-related proteins may play a specific role during gestation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6QPR5", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P05402-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05786-1", "uniprot_id": [ { "id": "K2C8_BOVIN", "url": "https://www.uniprot.org/uniprot/P05786", "type": "external" } ], "mass": 53627.0, "length": 478, "protein_name": "Keratin, type II cytoskeletal 8", "gene_name": "KRT8", "organism": "Bovine", "refseq_name": "keratin, type II cytoskeletal 8", "refseq_ac": [ { "id": "NP_001028782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028782", "type": "external" } ], "gene_names_uniprotkb": "KRT8", "gene_names_refseq": "KRT2-8; KRT8", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 8; CK-8; Cytokeratin-8; Cytokeratin-A; K8; Keratin-8; Type-II keratin Kb8", "protein_names_refseq": "CK-8; K8; KERA; cytokeratin 8; cytokeratin-A; keratin, type II cytoskeletal 8; type-II keratin Kb8", "tax_id": 9913, "disease": "", "pathway": " (bta:281269)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23113883;2422084;41018975", "class_list": "", "function": "Results did not support that K8/K18 filaments influence the expression of Fas on the surface of luteal cells. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells (By similarity). Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis (By similarity). Also required for ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement. In striated muscle, together with KRT19, may contribute to linking the contractile apparatus to dystrophin at the costameres (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYX7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:0045095 keratin filament", "go_biological_process": "GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P05786-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05805-1", "uniprot_id": [ { "id": "CAC3_BOVIN", "url": "https://www.uniprot.org/uniprot/P05805", "type": "external" } ], "mass": 27338.0, "length": 253, "protein_name": "Proproteinase E", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Proproteinase E; PROCPA-S6 III; Procarboxypeptidase A complex component III; Procarboxypeptidase A-S6 subunit III", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "2269366;3519215;7556081;8168476", "class_list": "", "function": "May protect procarboxypeptidase A against denaturation in the acidic environment of the ruminant duodenum., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P05805-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06504-1", "uniprot_id": [ { "id": "CRYGS_BOVIN", "url": "https://www.uniprot.org/uniprot/P06504", "type": "external" } ], "mass": 20928.0, "length": 178, "protein_name": "Gamma-crystallin S", "gene_name": "CRYGS", "organism": "Bovine", "refseq_name": "gamma-crystallin S", "refseq_ac": [ { "id": "NP_776717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776717", "type": "external" } ], "gene_names_uniprotkb": "CRYGS", "gene_names_refseq": "CRYGS", "protein_names_uniprotkb": "Gamma-crystallin S; Beta-crystallin S; Gamma-S-crystallin", "protein_names_refseq": "beta-crystallin S; crystallin, gamma polypeptide 8; gamma-S-crystallin; gamma-crystallin S", "tax_id": 9913, "disease": "", "pathway": " (bta:281724)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12529503;18509547;19085379;2476364;4054100;9681865", "class_list": "", "function": "Biophysical study on the nature and the magnitude of the gammaS-polyethylene glycol interactions, [RefSeq, PubMed]; Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]; Mass spectrometry analysis and a database search identified carbamylated proteins originating from alphaA-crystallin, betaB2- and gammaS-(betaS)-crystallins., [RefSeq, PubMed]; The results are consistent with the hypothesis that short-range, weak, attractive interactions between alpha- and gamma-crystallins are necessary for maximum transparency of the lens.[gamma crystallin] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P06504-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07106-1", "uniprot_id": [ { "id": "ACBD5_BOVIN", "url": "https://www.uniprot.org/uniprot/P07106", "type": "external" } ], "mass": 59653.0, "length": 533, "protein_name": "Acyl-CoA-binding domain-containing protein 5", "gene_name": "ACBD5", "organism": "Bovine", "refseq_name": "acyl-CoA-binding domain-containing protein 5", "refseq_ac": [ { "id": "NP_851381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851381", "type": "external" } ], "gene_names_uniprotkb": "ACBD5; DBI", "gene_names_refseq": "ACBD5", "protein_names_uniprotkb": "Acyl-CoA-binding domain-containing protein 5; Endozepine-related protein; MA-DBI; Membrane-associated diazepam-binding inhibitor", "protein_names_refseq": "MA-DBI; acyl-CoA-binding domain-containing protein 5; acyl-Coenzyme A binding domain containing 5; endozepine-related protein; membrane-associated diazepam-binding inhibitor", "tax_id": 9913, "disease": "", "pathway": " (bta:353160)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14527695;15178258;1780036;2881742", "class_list": "", "function": "Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity)., [UniProtKB]; Results demonstrate the presence of precursors to the folding transition state of bovine acyl-coenzyme A binding protein under acid-unfolding conditions., [RefSeq, PubMed]; Role of acyl-coenzyme A binding protein as an intermembrane transporter of acyl-CoA, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0I9", "ec_number_list": [], "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0000425 pexophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P07106-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07353-1", "uniprot_id": [ { "id": "IFNG_BOVIN", "url": "https://www.uniprot.org/uniprot/P07353", "type": "external" } ], "mass": 19393.0, "length": 166, "protein_name": "Interferon gamma", "gene_name": "IFNG", "organism": "Bovine", "refseq_name": "interferon gamma precursor", "refseq_ac": [ { "id": "NP_776511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776511", "type": "external" } ], "gene_names_uniprotkb": "IFNG", "gene_names_refseq": "IFNG", "protein_names_uniprotkb": "Interferon gamma; BoIFNG; IFN-gamma", "protein_names_refseq": "IFN-gamma; boIFNG; interferon gamma precursor; interferon gamma type 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281237); (R-BTA-877300); (R-BTA-877312); (R-BTA-9732724)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10666622;12396714;15299487;25924700;26962688;27473994;28544524;3086437;33963240", "class_list": "", "function": "Data suggest that luteolytic factors (such as IFNG, tumor necrosis factor alpha, and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells., [RefSeq, PubMed]; Diet-driven interferon-gamma enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Increase of cells expressing PD-1 and PD-L1 and enhancement of IFN-gamma production via PD-1/PD-L1 blockade in bovine mycoplasmosis., [RefSeq, PubMed]; Mucosal IFNgamma production and potential role in protection in Escherichia coli O157:H7 vaccinated and challenged cattle. Publication Status: Online-Only, [RefSeq, PubMed]; The entire bovine IFN-gamma gene (BoIFNG) and 2605 bp of its promoter DNA were sequenced. A comprehensive survey for polymorphisms in the bovine IFN-gamma gene reveals a highly polymorphic intronic DNA sequence allowing improved genotyping of Bovinae., [RefSeq, PubMed]; The expression of multiple toll-like receptors, interferon-gamma, and interleukin-12 (IL-12) in cattle with low and high proviral loads of bovine leukemia virus are reported., [RefSeq, PubMed]; Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A7L687;A9QWQ4", "ec_number_list": [], "go_molecular_function": "GO:0005133 type II interferon receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032834 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response;GO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process;GO:0060557 positive regulation of vitamin D biosynthetic process;GO:0032747 positive regulation of interleukin-23 production;GO:0032700 negative regulation of interleukin-17 production", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P07353-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07994-1", "uniprot_id": [ { "id": "INHA_BOVIN", "url": "https://www.uniprot.org/uniprot/P07994", "type": "external" } ], "mass": 38810.0, "length": 360, "protein_name": "Inhibin alpha chain", "gene_name": "INHA", "organism": "Bovine", "refseq_name": "inhibin alpha chain precursor", "refseq_ac": [ { "id": "NP_776519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776519", "type": "external" } ], "gene_names_uniprotkb": "INHA", "gene_names_refseq": "INHA", "protein_names_uniprotkb": "Inhibin alpha chain", "protein_names_refseq": "inhibin A; inhibin alpha chain precursor; inhibin alpha chain; inhibin alpha subunit; inhibin, alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:281254); (R-BTA-1502540); (R-BTA-201451); (R-BTA-209822); (R-BTA-9839406)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "12697695;18456314;20238172;25001504;27693012;2930562;3081385;3458167;7813465", "class_list": "", "function": "INHA gene can be used as a predictor for superovulation in Chinese Holstein cows., [RefSeq, PubMed]; Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor., [UniProtKB, UniProtKB]; Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Inhibin has a negative autocrine or paracrine effect on the in vitro capacity of granulosa cells isolated from dominant or subordinate follicles to produce estradiol., [RefSeq, PubMed]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB, UniProtKB]; Overexpression of inhibin alpha (1-32) fragment regulated granulosa cell development and effects on subsequent oocyte maturation were both time- and stage-dependent, [RefSeq, PubMed]; The effects of castration and other surgical intervention on the blood levels of anti-Muellerian hormone, inhibin A, gonadotropins, and gonadotropin receptors in bull calves are reported., [RefSeq, PubMed]; The expression of the components of the activin-inhibin-follistatin system is altered in bovine cystic ovarian disease., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q2TBQ2", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0043512 inhibin A complex;GO:0005615 extracellular space;GO:0034673 inhibin-betaglycan-ActRII complex", "go_biological_process": "GO:0048731 system development;GO:0046880 regulation of follicle-stimulating hormone secretion;GO:0042127 regulation of cell population proliferation;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0032926 negative regulation of activin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P07994-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08728-1", "uniprot_id": [ { "id": "K1C19_BOVIN", "url": "https://www.uniprot.org/uniprot/P08728", "type": "external" } ], "mass": 43885.0, "length": 399, "protein_name": "Keratin, type I cytoskeletal 19", "gene_name": "KRT19", "organism": "Bovine", "refseq_name": "keratin, type I cytoskeletal 19", "refseq_ac": [ { "id": "NP_001015600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015600", "type": "external" } ], "gene_names_uniprotkb": "KRT19", "gene_names_refseq": "KRT19", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 19; CK-19; Cytokeratin-19; K19; Keratin-19", "protein_names_refseq": "CK-19; K19; cytokeratin 19; keratin, type I cytoskeletal 19", "tax_id": 9913, "disease": "", "pathway": " (bta:514812); (R-BTA-6805567); (R-BTA-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "2428612", "class_list": "", "function": "Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1JQB4", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P08728-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08831-1", "uniprot_id": [ { "id": "IL1A_BOVIN", "url": "https://www.uniprot.org/uniprot/P08831", "type": "external" } ], "mass": 30833.0, "length": 268, "protein_name": "Interleukin-1 alpha", "gene_name": "IL1A", "organism": "Bovine", "refseq_name": "interleukin-1 alpha precursor", "refseq_ac": [ { "id": "NP_776517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776517", "type": "external" } ], "gene_names_uniprotkb": "IL1A", "gene_names_refseq": "IL1A", "protein_names_uniprotkb": "Interleukin-1 alpha; IL-1 alpha", "protein_names_refseq": "IL-1 alpha; interleukin-1 alpha precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281250); (R-BTA-448706); (R-BTA-5620971); (R-BTA-9020702)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "15253926;17174540;18930361;19144032;22287113;28716465;3261832;3262865", "class_list": "", "function": "Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity., [UniProtKB, UniProtKB]; Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF(2alpha) and PGE(2) production during luteal phase., [RefSeq, PubMed]; Non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties, [RefSeq, PubMed]; Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Testicular IL-1 alpha and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period., [RefSeq, PubMed]; These findings suggest that the elevated levels of IL-1alpha found in the osteoarthritis environment heighten fibroblast-like synoviocytes sensitivity to fluid shear by altering both intercellular communication and individual cell sensitivity, which could affect downstream functions and contribute to progression of the disease state, [RefSeq, PubMed]; These results suggest that IL-1alpha and IL-1beta are produced by the stromal cells, that IL-1beta is produced by the epithelial cells, and that IL-1alpha is a more potent stimulator of prostaglandin and plasminogen activator in bovine endometrial cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005507 copper ion binding;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0033092 positive regulation of immature T cell proliferation in thymus;GO:0001660 fever generation;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P08831-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09428-1", "uniprot_id": [ { "id": "IL1B_BOVIN", "url": "https://www.uniprot.org/uniprot/P09428", "type": "external" } ], "mass": 30760.0, "length": 266, "protein_name": "Interleukin-1 beta", "gene_name": "IL1B", "organism": "Bovine", "refseq_name": "interleukin-1 beta precursor", "refseq_ac": [ { "id": "NP_776518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776518", "type": "external" } ], "gene_names_uniprotkb": "IL1B", "gene_names_refseq": "IL1B", "protein_names_uniprotkb": "Interleukin-1 beta; IL-1 beta", "protein_names_refseq": "IL-1 beta; interleukin-1 beta precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281251)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15253926;28610788;32335355;32554268;3261832;3262866;33099841;37123145", "class_list": "", "function": "Expression of IL1beta Gene in the Placentas from Humans and Cows during Brucella Infection. Publication Status: Online-Only, [RefSeq, PubMed]; Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF(2alpha) and PGE(2) production during luteal phase., [RefSeq, PubMed]; IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2., [RefSeq, PubMed]; Mycobacterium bovis infected animals have a higher frequency of IFN-gamma producing CD4(+) T cells and elevated plasma IL-1beta levels., [RefSeq, PubMed]; Mycoplasma bovis induces matrix metalloproteinase-3 expression in bovine synovial cells via up-regulation of interleukin-1beta expression in mononuclear cells. Erratum:[Vet Immunol Immunopathol. 2021 Jan;231:110164. doi: 10.1016/j.vetimm.2020.110164. PMID: 33308875], [RefSeq, PubMed]; Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore., [UniProtKB, UniProtKB]; The NADL strain of bovine viral diarrhea virus induces the secretion of IL-1beta through caspase 1 in bovine macrophages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9QWQ5", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005125 cytokine activity;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:0033092 positive regulation of immature T cell proliferation in thymus;GO:0001660 fever generation;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P09428-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09851-1", "uniprot_id": [ { "id": "RASA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P09851", "type": "external" } ], "mass": 115761.0, "length": 1044, "protein_name": "Ras GTPase-activating protein 1", "gene_name": "RASA1", "organism": "Bovine", "refseq_name": "ras GTPase-activating protein 1", "refseq_ac": [ { "id": "NP_776874", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776874", "type": "external" } ], "gene_names_uniprotkb": "RASA1; RASA", "gene_names_refseq": "RASA1", "protein_names_uniprotkb": "Ras GTPase-activating protein 1; GAP; GTPase-activating protein; Ras p21 protein activator; RasGAP; p120GAP", "protein_names_refseq": "GAP; GTPase-activating protein; RAS p21 protein activator (GTPase activating protein RAS p21); p120GAP; ras GTPase-activating protein 1; rasGAP", "tax_id": 9913, "disease": "", "pathway": " (bta:282032)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21103953;2842690", "class_list": "", "function": "GTPase-activating protein (GAP) that stimulates the intrinsic GTPase activity of Ras proteins, such as NRAS, facilitating their transition from the active GTP-bound state to the inactive GDP-bound state, thereby terminating Ras signaling., [UniProtKB, UniProtKB]; The data suggest that nitrosylation of H-Ras rearranges the adsorptive potential and intrinsic GTPase activity of H-Ras through modification of C-terminal cysteines of molecule., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005102 signaling receptor binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001570 vasculogenesis;GO:0007162 negative regulation of cell adhesion;GO:0007165 signal transduction;GO:0043524 negative regulation of neuron apoptotic process;GO:0001953 negative regulation of cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P09851-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C591-1", "uniprot_id": [ { "id": "DUS29_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C591", "type": "external" } ], "mass": 24984.0, "length": 219, "protein_name": "Dual specificity phosphatase 29", "gene_name": "DUSP29", "organism": "Bovine", "refseq_name": "dual specificity phosphatase 29 isoform X1", "refseq_ac": [ { "id": "XP_005226533", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226533", "type": "external" } ], "gene_names_uniprotkb": "DUSP29; DUPD1", "gene_names_refseq": "DUPD1; DUSP29", "protein_names_uniprotkb": "Dual specificity phosphatase 29; 3.1.3.16; 3.1.3.48; Dual specificity phosphatase DUPD1", "protein_names_refseq": "dual specificity phosphatase 29 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "11282978", "class_list": "", "function": "Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of intracellular signaling cascades. May regulate glucose metabolism by activating, AMPK, an energy sensor protein kinase. Affects MAP kinase signaling though modulation of the ERK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0033549 MAP kinase phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0042593 glucose homeostasis;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0006470 protein dephosphorylation;GO:0042692 muscle cell differentiation;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C591-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C8Z3-1", "uniprot_id": [ { "id": "UBP22_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C8Z3", "type": "external" } ], "mass": 58737.0, "length": 514, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 22", "gene_name": "USP22", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 22", "refseq_ac": [ { "id": "NP_001160039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160039", "type": "external" } ], "gene_names_uniprotkb": "USP22", "gene_names_refseq": "USP22", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 22; 3.4.19.12; Deubiquitinating enzyme 22; Ubiquitin thioesterase 22; Ubiquitin-specific-processing protease 22", "protein_names_refseq": "deubiquitinating enzyme 22; ubiquitin carboxyl-terminal hydrolase 22; ubiquitin thioesterase 22; ubiquitin thiolesterase 22; ubiquitin-specific-processing protease 22", "tax_id": 9913, "disease": "", "pathway": " (bta:509694); (R-BTA-5689880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. As part of the transcription regulatory histone acetylation (HAT) complex SAGA, catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a transcriptional coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Facilitates cell-cycle progression by stabilizing CCNB1 and antagonizing its proteasome-mediated degradation in a cell cycle-specific manner. Modulates cell cycle progression and apoptosis also by antagonizing TP53 transcriptional activation through deacetylase SIRT1 stabilization. Plays multiple roles in immunity and inflammation. Participates in antiviral response by deubiquitinating the importin KPNA2, leading to IRF3 nuclear translocation and subsequent type I interferon production. Acts as a central regulator of type III IFN signaling by negatively regulating STING1 activation and ubiquitination (By similarity). Inhibits NLRP3 inflammasome activation by promoting NLRP3 degradation through ATG5-dependent autophagy (By similarity). Deubiquitinates CD274 to induce its stabilization and thereby participates in maintenance of immune tolerance to self. Controls necroptotic cell death by regulating RIPK3 phosphorylation and ubiquitination (By similarity). During bacterial infection, promotes pro-inflammatory response by targeting TRAF6 and removing its 'Lys-48'-linked polyubiquitination (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000124 SAGA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C8Z3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10948-1", "uniprot_id": [ { "id": "RAB3B_BOVIN", "url": "https://www.uniprot.org/uniprot/P10948", "type": "external" } ], "mass": 24766.0, "length": 219, "protein_name": "Ras-related protein Rab-3B", "gene_name": "RAB3B", "organism": "Bovine", "refseq_name": "ras-related protein Rab-3B", "refseq_ac": [ { "id": "NP_776872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776872", "type": "external" } ], "gene_names_uniprotkb": "RAB3B", "gene_names_refseq": "RAB3B", "protein_names_uniprotkb": "Ras-related protein Rab-3B; 3.6.5.2; SMG P25B", "protein_names_refseq": "SMG P25B; ras-related protein Rab-3B", "tax_id": 9913, "disease": "", "pathway": " (bta:282030); (R-BTA-8873719)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "3136152", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0IIB4", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031489 myosin V binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P10948-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11017-1", "uniprot_id": [ { "id": "GBB2_BOVIN", "url": "https://www.uniprot.org/uniprot/P11017", "type": "external" } ], "mass": 37331.0, "length": 340, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2", "gene_name": "GNB2", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2", "refseq_ac": [ { "id": "NP_001091030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091030", "type": "external" } ], "gene_names_uniprotkb": "GNB2", "gene_names_refseq": "GNB2; HG2C1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; G protein subunit beta-2; Transducin beta chain 2", "protein_names_refseq": "g protein subunit beta-2; guanine nucleotide binding protein (G protein),beta polypeptide 2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; heterotrimeric guanine nucleotide-binding protein 2C1; transducin beta chain 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281202); (R-BTA-1296041); (R-BTA-202040); (R-BTA-381676); (R-BTA-392170); (R-BTA-392451); (R-BTA-392851); (R-BTA-400042); (R-BTA-4086398); (R-BTA-416476); (R-BTA-416482); (R-BTA-418217); (R-BTA-418555); (R-BTA-418592); (R-BTA-418594); (R-BTA-418597); (R-BTA-420092); (R-BTA-428930); (R-BTA-432040); (R-BTA-456926); (R-BTA-500657); (R-BTA-6814122); (R-BTA-8964315); (R-BTA-8964616); (R-BTA-9009391); (R-BTA-9856530); (R-BTA-997272)", "pathway_count": 27, "publication_count": 2, "publication_id_list": "3108879;3114742", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D7A9", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P11017-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11178-1", "uniprot_id": [ { "id": "ODBA_BOVIN", "url": "https://www.uniprot.org/uniprot/P11178", "type": "external" } ], "mass": 51678.0, "length": 455, "protein_name": "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial", "gene_name": "BCKDHA", "organism": "Bovine", "refseq_name": "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776931", "type": "external" } ], "gene_names_uniprotkb": "BCKDHA", "gene_names_refseq": "BCKDHA", "protein_names_uniprotkb": "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; 1.2.4.4; BCKDE1A; BCKDH E1-alpha; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain", "protein_names_refseq": "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor; 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; BCKDE1A; BCKDH E1-alpha; branched chain keto acid dehydrogenase E1, alpha polypeptide (maple syrup urine disease); branched-chain alpha-keto acid dehydrogenase E1 component alpha chain", "tax_id": 9913, "disease": "", "pathway": " (bta:282149)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "283398;3379058;447664;5656388", "class_list": "", "function": "Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003863 branched-chain 2-oxo acid dehydrogenase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0160157 branched-chain alpha-ketoacid dehydrogenase complex", "go_biological_process": "GO:0009083 branched-chain amino acid catabolic process;GO:0120552 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P11178-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11843-1", "uniprot_id": [ { "id": "CRBA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P11843", "type": "external" } ], "mass": 25131.0, "length": 215, "protein_name": "Beta-crystallin A3", "gene_name": "CRYBA1", "organism": "Bovine", "refseq_name": "beta-crystallin A3", "refseq_ac": [ { "id": "NP_776948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776948", "type": "external" } ], "gene_names_uniprotkb": "CRYBA1", "gene_names_refseq": "CRYBA1", "protein_names_uniprotkb": "Beta-crystallin A3", "protein_names_refseq": "beta A3 crystallin; beta-crystallin A3; lens structural protein", "tax_id": 9913, "disease": "", "pathway": " (bta:282202)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17651443;6527379;6547897;6698025", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]; Results show that both betaB2- and betaA3-crystallin bind calcium with moderate affinity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P79425;Q6DTZ7;Q95113", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P11843-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12260-1", "uniprot_id": [ { "id": "F13A_BOVIN", "url": "https://www.uniprot.org/uniprot/P12260", "type": "external" } ], "mass": 22745.0, "length": 198, "protein_name": "Coagulation factor XIII A chain", "gene_name": "F13A1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "F13A1; F13A", "gene_names_refseq": "", "protein_names_uniprotkb": "Coagulation factor XIII A chain; 2.3.2.13; Coagulation factor XIIIa; Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "16305752;4831071", "class_list": "", "function": "Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1JPK3", "ec_number_list": [ { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.5.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:0018149 peptide cross-linking;GO:0072378 blood coagulation, fibrin clot formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P12260-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12342-1", "uniprot_id": [ { "id": "IL2RA_BOVIN", "url": "https://www.uniprot.org/uniprot/P12342", "type": "external" } ], "mass": 31239.0, "length": 275, "protein_name": "Interleukin-2 receptor subunit alpha", "gene_name": "IL2RA", "organism": "Bovine", "refseq_name": "interleukin-2 receptor subunit alpha precursor", "refseq_ac": [ { "id": "NP_776783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776783", "type": "external" } ], "gene_names_uniprotkb": "IL2RA", "gene_names_refseq": "CD25; IL2RA", "protein_names_uniprotkb": "Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; TAC antigen; p55", "protein_names_refseq": "IL-2 receptor alpha subunit; IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha; IL-2R subunit alpha; IL2-RA; TAC antigen; cytokine receptor; interleukin 2 receptor, alpha; interleukin-2 receptor alpha chain; interleukin-2 receptor subunit alpha precursor; p55", "tax_id": 9913, "disease": "", "pathway": " (bta:281861)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12496181;12906107;18928784;23059841;25001909;25106916;25456194;2835311;8563178", "class_list": "", "function": "Determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25, CD44, and CD62L expression on peripheral blood T-cell subsets from M. bovis-infected cattle., [RefSeq, PubMed]; Differential expression of CD25 and IDO mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains., [RefSeq, PubMed]; Increase of CD25 expression on bovine neutrophils correlates with mastitis severity in post-partum and early lactating dairy cows., [RefSeq, PubMed]; Pretreatment of neonatal PBMC with IL-1beta, TNF-alpha or IFN-gamma promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor., [RefSeq, PubMed]; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells., [UniProtKB, UniProtKB]; The PGE2-mediated down-regulation of CD25 expression on T cells is mediated via the EP4 receptor, although selective activation of the EP2 receptor up-regulates the CD25 expression on these cells., [RefSeq, PubMed]; There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8(+) cells., [RefSeq, PubMed]; These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004911 interleukin-2 receptor activity;GO:0019976 interleukin-2 binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0002682 regulation of immune system process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P12342-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12378-1", "uniprot_id": [ { "id": "UGDH_BOVIN", "url": "https://www.uniprot.org/uniprot/P12378", "type": "external" } ], "mass": 55136.0, "length": 494, "protein_name": "UDP-glucose 6-dehydrogenase", "gene_name": "UGDH", "organism": "Bovine", "refseq_name": "UDP-glucose 6-dehydrogenase", "refseq_ac": [ { "id": "NP_776636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776636", "type": "external" } ], "gene_names_uniprotkb": "UGDH", "gene_names_refseq": "UGDH", "protein_names_uniprotkb": "UDP-glucose 6-dehydrogenase; 1.1.1.22; UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH", "protein_names_refseq": "UDP-Glc dehydrogenase; UDP-GlcDH; UDP-glucose 6-dehydrogenase; UDP-glucose dehydrogenase; UDPGDH", "tax_id": 9913, "disease": "", "pathway": " (bta:281564); (R-BTA-173599)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10336992;6896145;7920253", "class_list": "", "function": "Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (By similarity). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6QR10;O77806", "ec_number_list": [ { "id": "1.1.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.22", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0003979 UDP-glucose 6-dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001702 gastrulation with mouth forming second;GO:0006024 glycosaminoglycan biosynthetic process;GO:0048666 neuron development;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P12378-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12661-1", "uniprot_id": [ { "id": "RET3_BOVIN", "url": "https://www.uniprot.org/uniprot/P12661", "type": "external" } ], "mass": 139698.0, "length": 1286, "protein_name": "Retinol-binding protein 3", "gene_name": "RBP3", "organism": "Bovine", "refseq_name": "retinol-binding protein 3 precursor", "refseq_ac": [ { "id": "NP_776589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776589", "type": "external" } ], "gene_names_uniprotkb": "RBP3", "gene_names_refseq": "RBP3", "protein_names_uniprotkb": "Retinol-binding protein 3; IRBP; Interphotoreceptor retinoid-binding protein; Interstitial retinol-binding protein; Protein 7S", "protein_names_refseq": "7S protein; IRBP; interphotoreceptor retinoid-binding protein; interstitial retinol-binding protein; protein 7S; retinol binding protein 3, interstitial; retinol-binding protein 3 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281443)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "11359436;1371240;14568955;14607971;15963234;1690082;1694880;1707928;1709661;17200663;19234216;23876239;24029580;2413855;2471769;2477180;2676730;2910846;2981203;3827838;7514128;7516403;8050169;8242769;9126974;9603463", "class_list": "", "function": "IRBP is able to bind a variety of carotenoids at an affinity comparable to retinoids and with much stronger affinity than any fatty acid tested., [RefSeq, PubMed]; In mouse immunization studies Ehrlichia canis amino acid sequence 44-59 is identified as a candidate mimicry epitope for interphotoreceptor retinoid-binding protein (IRBP) 201-216 and is capable of preventing ocular inflammation., [RefSeq, PubMed]; KLF15 binds to multiple 9 bp consensus sites in the Rhodospin and IRBP promoters including the CRS-1 and G-rich repressor elements. Publication Status: Online-Only, [RefSeq, PubMed]; Localized to interphotoreceptor matrix, where it is available for binding and transport of visual cycle retinoids. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the transport of 11-cis- and all-trans-retinoids between the retinal pigment epithelium (RPE) and photoreceptors, facilitating retinoid exchange required for the visual cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0090658 cone matrix sheath", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P12661-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13204-1", "uniprot_id": [ { "id": "ANFB_BOVIN", "url": "https://www.uniprot.org/uniprot/P13204", "type": "external" } ], "mass": 14113.0, "length": 129, "protein_name": "Natriuretic peptides B", "gene_name": "NPPB", "organism": "Bovine", "refseq_name": "natriuretic peptides B precursor", "refseq_ac": [ { "id": "NP_001160042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160042", "type": "external" } ], "gene_names_uniprotkb": "NPPB", "gene_names_refseq": "Iso-ANP; NPPB", "protein_names_uniprotkb": "Natriuretic peptides B; Brain natriuretic factor prohormone; Gamma-brain natriuretic peptide; Iso-ANP; preproBNP; proBNP", "protein_names_refseq": "brain natriuretic factor prohormone; gamma-brain natriuretic peptide; natriuretic peptide precursor B; natriuretic peptides B precursor; natriuretic peptides B; preproBNP; proBNP", "tax_id": 9913, "disease": "", "pathway": " (bta:508734)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19393038;2532709;2537187", "class_list": "", "function": "Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MWE9", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0051427 hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0007218 neuropeptide signaling pathway;GO:0097746 blood vessel diameter maintenance;GO:0006457 protein folding;GO:0003085 negative regulation of systemic arterial blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P13204-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13384-1", "uniprot_id": [ { "id": "IBP2_BOVIN", "url": "https://www.uniprot.org/uniprot/P13384", "type": "external" } ], "mass": 34015.0, "length": 317, "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "organism": "Bovine", "refseq_name": "insulin-like growth factor-binding protein 2 precursor", "refseq_ac": [ { "id": "NP_776980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776980", "type": "external" } ], "gene_names_uniprotkb": "IGFBP2", "gene_names_refseq": "IGFBP2", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 2; IBP-2; IGF-binding protein 2; IGFBP-2", "protein_names_refseq": "IBP-2; IGF-binding protein 2; IGFBP-2; insulin-like growth factor binding protein 2, 36kDa; insulin-like growth factor-binding protein 2 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:282260); (R-BTA-381426)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1377702;1697752;21940120;22537059;2450535", "class_list": "", "function": "Five novel SNPs were identified in IGFBP2, two of which had significant associations with fertility (age at conception in heifers and commencement of luteal activity) and 305-day milk yield in lactation 1., [RefSeq, PubMed]; Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation. Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury., [UniProtKB, UniProtKB]; The present study suggests that the insulin like growth factor (IGF) system or imbalances between IGF and IGF binding proteins may be involved in cystic ovary disease of cattle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97599", "ec_number_list": [], "go_molecular_function": "GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0032868 response to insulin;GO:0042104 positive regulation of activated T cell proliferation;GO:0043567 regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P13384-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13696-1", "uniprot_id": [ { "id": "PEBP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P13696", "type": "external" } ], "mass": 20986.0, "length": 187, "protein_name": "Phosphatidylethanolamine-binding protein 1", "gene_name": "PEBP1", "organism": "Bovine", "refseq_name": "phosphatidylethanolamine-binding protein 1", "refseq_ac": [ { "id": "NP_001028795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028795", "type": "external" } ], "gene_names_uniprotkb": "PEBP1; PBP; PEBP", "gene_names_refseq": "PBP; PEBP1; PEBP", "protein_names_uniprotkb": "Phosphatidylethanolamine-binding protein 1; Basic cytosolic 21 kDa protein; HCNPpp; PEBP-1", "protein_names_refseq": "HCNPpp; PEBP-1; basic cytosolic 21 kDa protein; phosphatidylethanolamine-binding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:431786); (R-BTA-5674135); (R-BTA-5675221)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12492898;14724289;19564817;21529916;3609012;9782057", "class_list": "", "function": "Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity)., [UniProtKB]; Data suggest that phosphatidylethanolamine-binding protein (PEBP) and hippocampal cholinergic neurostimulating peptide (HCNP), the N-terminal fragment of the secreted PEBP, might be considered as new endocrine factors involved in cardiac physiology [PEBP], [RefSeq, PubMed]; HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity)., [UniProtKB]; NMR structure of the N- and C-terminal protein fragments [PEBP], [RefSeq, PubMed]; PEBP1 mRNA levels are associated with male fertility., [RefSeq, PubMed]; The investigation of PEBP binding properties towards morphine and morphine analogs, is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0H9", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005524 ATP binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P13696-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14568-1", "uniprot_id": [ { "id": "ASSY_BOVIN", "url": "https://www.uniprot.org/uniprot/P14568", "type": "external" } ], "mass": 46417.0, "length": 412, "protein_name": "Argininosuccinate synthase", "gene_name": "ASS1", "organism": "Bovine", "refseq_name": "argininosuccinate synthase", "refseq_ac": [ { "id": "NP_776317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776317", "type": "external" } ], "gene_names_uniprotkb": "ASS1", "gene_names_refseq": "ASS1; ASS; CN", "protein_names_uniprotkb": "Argininosuccinate synthase; 6.3.4.5; Citrulline--aspartate ligase", "protein_names_refseq": "argininosuccinate synthase; argininosuccinate synthetase 1; citrulline--aspartate ligase; citrullinemia; mutant arginino succinate synthetase", "tax_id": 9913, "disease": "", "pathway": " (bta:280726); (R-BTA-70635)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14970240;15851478;17496212;18948083;22696221;2813370", "class_list": "", "function": "Calcium-dependent phosphorylation of argininosuccinate synthase Ser-328 is mediated by PKCalpha, [RefSeq, PubMed]; Dose-dependent reduction of ASS as a result of siRNA treatment corresponded to diminished capacity to produce NO, despite saturating levels of arginine in the medium; reduced expression of ASS resulted in loss of viability due to apoptosis, [RefSeq, PubMed]; In endothelial cells TNF-alpha coordinately downregulates nitric oxide synthase (eNOS) and argininosuccinate synthase expression, resulting in a severely impaired citrulline-NO cycle., [RefSeq, PubMed]; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues., [UniProtKB, UniProtKB]; The function of the extended 5'-UTRs of AS mRNA was investigated, [RefSeq, PubMed]; These results represent the first demonstration that vascular endothelial nitric oxide production can be regulated by dynamic argininosuccinate synthase phosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0A7", "ec_number_list": [ { "id": "6.3.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004055 argininosuccinate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007623 circadian rhythm;GO:0000050 urea cycle;GO:0000053 argininosuccinate metabolic process;GO:0006526 L-arginine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P14568-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15781-1", "uniprot_id": [ { "id": "PSPB_BOVIN", "url": "https://www.uniprot.org/uniprot/P15781", "type": "external" } ], "mass": 41060.0, "length": 373, "protein_name": "Pulmonary surfactant-associated protein B", "gene_name": "SFTPB", "organism": "Bovine", "refseq_name": "pulmonary surfactant-associated protein B precursor", "refseq_ac": [ { "id": "NP_001068779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068779", "type": "external" } ], "gene_names_uniprotkb": "SFTPB; SFTP3", "gene_names_refseq": "SFTPB", "protein_names_uniprotkb": "Pulmonary surfactant-associated protein B; 6 kDa protein; Pulmonary surfactant-associated proteolipid SPL(Phe); SP-B", "protein_names_refseq": "6 kDa protein; SP-B; pulmonary surfactant-associated protein B precursor; pulmonary surfactant-associated protein B; pulmonary surfactant-associated proteolipid SPL(Phe); surfactant, pulmonary-associated protein B", "tax_id": 9913, "disease": "", "pathway": " (bta:507398); (R-BTA-5683826)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17425286;18088070;20409474;22037357;22252270;3663690;3689402", "class_list": "", "function": "Measurements of the depth of SP-B(CTERM) indicated the peptide center positions ~8A more deeply than the phosphate headgroups, a topology that may allow the peptide to promote functional lipid structures without causing micellization upon compression., [RefSeq, PubMed]; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter., [UniProtKB]; Reactive oxygen species inactivation of lipid extract surfactant B (SP-B) biophysical activity appears to involve modification of a maximum of three amino acids: Trp9, Met29, and Met65., [RefSeq, PubMed]; Results suggest the hydrophobic surfactant protein, SP-B, protects alveolar surfactant phospholiopids from hydrolysis mediated by multiple sPLA(2) in both vesicles (alveolar subphase) and monomolecular films (air-liquid interface), [RefSeq, PubMed]; The hydrophobic surfactant proteins SP-B and SP-C induce formation of bicontinuous inverse cubic phases., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q148E8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005764 lysosome;GO:0097208 alveolar lamellar body;GO:0005771 multivesicular body", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0007585 respiratory gaseous exchange by respiratory system", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P15781-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16586-1", "uniprot_id": [ { "id": "PDE6C_BOVIN", "url": "https://www.uniprot.org/uniprot/P16586", "type": "external" } ], "mass": 98798.0, "length": 855, "protein_name": "Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'", "gene_name": "PDE6C", "organism": "Bovine", "refseq_name": "cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'", "refseq_ac": [ { "id": "NP_776844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776844", "type": "external" } ], "gene_names_uniprotkb": "PDE6C; PDEA2", "gene_names_refseq": "PDE6C", "protein_names_uniprotkb": "Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; 3.1.4.35; PDE V-C1; cGMP phosphodiesterase 6C", "protein_names_refseq": "PDE V-C1; cGMP phosphodiesterase 6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; phosphodiesterase 6C, cGMP-specific, cone, alpha prime; phosphodiesterase, cyclic GMP (cone receptor)", "tax_id": 9913, "disease": "", "pathway": " (bta:281975)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2153290;2153291", "class_list": "", "function": "As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0097381 photoreceptor disc membrane;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P16586-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17248-1", "uniprot_id": [ { "id": "SYWC_BOVIN", "url": "https://www.uniprot.org/uniprot/P17248", "type": "external" } ], "mass": 53812.0, "length": 476, "protein_name": "Tryptophan--tRNA ligase, cytoplasmic", "gene_name": "WARS1", "organism": "Bovine", "refseq_name": "tryptophan--tRNA ligase, cytoplasmic", "refseq_ac": [ { "id": "NP_776643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776643", "type": "external" } ], "gene_names_uniprotkb": "WARS1; WARS", "gene_names_refseq": "WARS1; WARS", "protein_names_uniprotkb": "Tryptophan--tRNA ligase, cytoplasmic; 6.1.1.2; TrpRS; Tryptophanyl-tRNA synthetase", "protein_names_refseq": "trpRS; tryptophan--tRNA ligase, cytoplasmic; tryptophanyl-tRNA synthetase, cytoplasmic", "tax_id": 9913, "disease": "", "pathway": " (bta:281576)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15579907;1907847;2631684", "class_list": "", "function": "A VE-cadherin-dependent pathway may link T2-TrpRS to inhibition of new blood vessel formation Erratum:[J Biol Chem. 2007 Sep 28;282(39):29068], [RefSeq, PubMed]; T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZK9", "ec_number_list": [ { "id": "6.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0045765 regulation of angiogenesis;GO:0006436 tryptophanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P17248-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17667-1", "uniprot_id": [ { "id": "MYF5_BOVIN", "url": "https://www.uniprot.org/uniprot/P17667", "type": "external" } ], "mass": 28242.0, "length": 255, "protein_name": "Myogenic factor 5", "gene_name": "MYF5", "organism": "Bovine", "refseq_name": "myogenic factor 5", "refseq_ac": [ { "id": "NP_776541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776541", "type": "external" } ], "gene_names_uniprotkb": "MYF5", "gene_names_refseq": "MYF5", "protein_names_uniprotkb": "Myogenic factor 5; Myf-5", "protein_names_refseq": "myf-5; myogenic factor 5", "tax_id": 9913, "disease": "", "pathway": " (bta:281335); (R-BTA-525793)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12149576;14753343;20127165;2356114;23640900;25023801;32220486;32564663;7684719", "class_list": "", "function": "A polymorphism showed an influence on Myf5 gene expression in the longissimus dorsi muscle, [RefSeq, PubMed]; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity)., [UniProtKB]; Association between polymorphisms of Myf5, MSTN and CAST genes and fattening performance in Brown Swiss and Holstein cattle breeds., [RefSeq, PubMed]; Bos taurus MYF5 activates MYF5 and MYOD1 expression in cultured fibroblasts., [RefSeq, PubMed]; Genetic variants in MYF5 affected growth traits and beef quality traits in Chinese Qinchuan cattle., [RefSeq, PubMed]; Results suggest that MyoD and Myf5 influence the MyHC isoform expression, although the effects are not decisive in specifying the phenotypes of adult muscles, [RefSeq, PubMed]; Significantly associated with higher preweaning average daily gain and higher average daily gain on feed, [RefSeq, PubMed]; The effects of myostatin and myogenic factor 5 polymorphisms on growth and muscle traits of Marchigiana breed were assessed., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H7F1;Q1T6Y4", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0035914 skeletal muscle cell differentiation;GO:0048743 positive regulation of skeletal muscle fiber development;GO:0045663 positive regulation of myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P17667-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18130-1", "uniprot_id": [ { "id": "ADA1A_BOVIN", "url": "https://www.uniprot.org/uniprot/P18130", "type": "external" } ], "mass": 51466.0, "length": 466, "protein_name": "Alpha-1A adrenergic receptor", "gene_name": "ADRA1A", "organism": "Bovine", "refseq_name": "alpha-1A adrenergic receptor", "refseq_ac": [ { "id": "NP_776923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776923", "type": "external" } ], "gene_names_uniprotkb": "ADRA1A; ADRA1C", "gene_names_refseq": "ADRA1A", "protein_names_uniprotkb": "Alpha-1A adrenergic receptor; Alpha-1A adrenoceptor; Alpha-1A adrenoreceptor; Alpha-1C adrenergic receptor", "protein_names_refseq": "adrenergic, alpha-1A-, receptor; alpha-1A adrenergic receptor; alpha-1A adrenoceptor; alpha-1A adrenoreceptor", "tax_id": 9913, "disease": "", "pathway": " (bta:282134)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1334487;15178433;15603588;1966743;1970822;25497806", "class_list": "", "function": "Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C (PubMed:1334487). ADRA1A binds the catecholamine ligands norepinephrine and epinephrine (PubMed:1334487). Can also couple to G(14) protein (PubMed:1334487). Nuclear ADRA1A forms heterooligomers with ADRA1B to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. At the plasma membrane, ADRA1A interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy (By similarity). Additionally, functions as a vasopressor in resistance arteries and plays a role in maintaining normal arterial blood pressure (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Modeling of full-length alpha(1a) adrenergic receptor due to its biological role and significant implications in pharmacological treatment of benign prostate hyperplasia, [RefSeq, PubMed]; Stimulation of transfected bovine alpha1A-AR promotes cell cycle arrest, hypertrophy and differentiation of fibroblasts into smooth muscle-like cells and expression of negative cell cycle regulators by a mechanism independent of cAMP/PKA signaling Publication Status: Online-Only, [RefSeq, PubMed]; These results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of alpha1-adrenergic receptor and glucocorticoid receptor with neonatal glucose and lipid metabolism., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0004937 alpha1-adrenergic receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005901 caveola", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0019229 regulation of vasoconstriction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P18130-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18892-1", "uniprot_id": [ { "id": "BT1A1_BOVIN", "url": "https://www.uniprot.org/uniprot/P18892", "type": "external" } ], "mass": 59277.0, "length": 526, "protein_name": "Butyrophilin subfamily 1 member A1", "gene_name": "BTN1A1", "organism": "Bovine", "refseq_name": "butyrophilin subfamily 1 member A1 precursor", "refseq_ac": [ { "id": "NP_776933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776933", "type": "external" } ], "gene_names_uniprotkb": "BTN1A1; BTN", "gene_names_refseq": "BTN1A1; BTN; BT", "protein_names_uniprotkb": "Butyrophilin subfamily 1 member A1; BT", "protein_names_refseq": "butyrophilin subfamily 1 member A1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:282157)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14688379;2387867;35189067;7775382", "class_list": "", "function": "BTN present in milk and dairy products may influence the composition and function of myelin oligodendrocyte glycoprotein (MOG)-specific autoimmune repertoire during the course of multiple sclerosis., [RefSeq, PubMed]; High resolution melt curve analysis identifies a novel SNP (G21A) in butyrophilin gene having significant association with milk production traits in Holstein Friesian crossbreds of Kerala., [RefSeq, PubMed]; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O18955;O18959;O46535;Q6RUS3", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P18892-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18902-1", "uniprot_id": [ { "id": "RET4_BOVIN", "url": "https://www.uniprot.org/uniprot/P18902", "type": "external" } ], "mass": 21069.0, "length": 183, "protein_name": "Retinol-binding protein 4", "gene_name": "RBP4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RBP4", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinol-binding protein 4; PRBP; Plasma retinol-binding protein; RBP", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "12787682;1623143;17255476;18419130;2209607;8373966;8496140", "class_list": "", "function": "Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0034632 retinol transmembrane transporter activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0034633 retinol transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P18902-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19034-1", "uniprot_id": [ { "id": "APOC2_BOVIN", "url": "https://www.uniprot.org/uniprot/P19034", "type": "external" } ], "mass": 11061.0, "length": 101, "protein_name": "Apolipoprotein C-II", "gene_name": "APOC2", "organism": "Bovine", "refseq_name": "apolipoprotein C-II precursor", "refseq_ac": [ { "id": "NP_001095850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095850", "type": "external" } ], "gene_names_uniprotkb": "APOC2", "gene_names_refseq": "APOC2", "protein_names_uniprotkb": "Apolipoprotein C-II; Apo-CII; ApoC-II; Apolipoprotein C2", "protein_names_refseq": "apo-CII; apoC-II; apolipoprotein C-II precursor; apolipoprotein C-II", "tax_id": 9913, "disease": "", "pathway": " (bta:618039); (R-BTA-8963888); (R-BTA-8963901); (R-BTA-8964058); (R-BTA-975634)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10675035;16075062;2209608", "class_list": "", "function": "Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H771;Q71VH7", "ec_number_list": [], "go_molecular_function": "GO:0060230 lipoprotein lipase activator activity;GO:0016004 phospholipase activator activity;GO:0043274 phospholipase binding", "go_cellular_component": "GO:0034363 intermediate-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle;GO:0034366 spherical high-density lipoprotein particle;GO:0042627 chylomicron;GO:0034362 low-density lipoprotein particle", "go_biological_process": "GO:0006869 lipid transport;GO:0010898 positive regulation of triglyceride catabolic process;GO:0016042 lipid catabolic process;GO:0034384 high-density lipoprotein particle clearance;GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P19034-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19111-1", "uniprot_id": [ { "id": "PPBI_BOVIN", "url": "https://www.uniprot.org/uniprot/P19111", "type": "external" } ], "mass": 57100.0, "length": 533, "protein_name": "Intestinal-type alkaline phosphatase", "gene_name": "ALPI", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ALPI", "gene_names_refseq": "", "protein_names_uniprotkb": "Intestinal-type alkaline phosphatase; 3.1.3.1; IAP; Intestinal alkaline phosphatase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "3458202;3902089;8452539", "class_list": "", "function": "Alkaline phosphatase that can hydrolyze various phosphate compounds., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q28124", "ec_number_list": [ { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" } ], "go_molecular_function": "GO:0004035 alkaline phosphatase activity;GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0016311 dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P19111-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19535-1", "uniprot_id": [ { "id": "CADH3_BOVIN", "url": "https://www.uniprot.org/uniprot/P19535", "type": "external" } ], "mass": 54208.0, "length": 491, "protein_name": "Cadherin-3", "gene_name": "CDH3", "organism": "Bovine", "refseq_name": "cadherin-3 precursor", "refseq_ac": [ { "id": "NP_001231534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231534", "type": "external" } ], "gene_names_uniprotkb": "CDH3; CDHP", "gene_names_refseq": "CDH3", "protein_names_uniprotkb": "Cadherin-3; P-cadherin; Placental cadherin", "protein_names_refseq": "cadherin 15, M-cadherin (myotubule); cadherin 3, P-cadherin (placental); cadherin 3, type 1, P-cadherin (placental); cadherin-3 precursor; placental cadherin", "tax_id": 9913, "disease": "", "pathway": " (bta:281063)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2390969", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P19535-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19782-1", "uniprot_id": [ { "id": "PRM2_BOVIN", "url": "https://www.uniprot.org/uniprot/P19782", "type": "external" } ], "mass": 13646.0, "length": 115, "protein_name": "Protamine-2", "gene_name": "PRM2", "organism": "Bovine", "refseq_name": "protamine-2", "refseq_ac": [ { "id": "NP_776582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776582", "type": "external" } ], "gene_names_uniprotkb": "PRM2", "gene_names_refseq": "PRM2", "protein_names_uniprotkb": "Protamine-2; Sperm histone P2; Sperm protamine P2", "protein_names_refseq": "protamine-2; sperm histone P2; sperm protamine P2", "tax_id": 9913, "disease": "", "pathway": " (bta:281424)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1390885;23044178;2320417;30920782", "class_list": "", "function": "Our study, for the first time, described the amount of PRM2 transcripts in spermatozoa and testis and quantified the differential mRNA number of copies., [RefSeq, PubMed]; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex., [UniProtKB, UniProtKB]; This study was conducted to isolate high-quality RNA from mature spermatozoa and to monitor the expression profile of PRM1 and PRM2 gene in ejaculated spermatozoa of normal and motility impaired bulls., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q02097;Q28171;Q32L38", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0030261 chromosome condensation;GO:0006997 nucleus organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P19782-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19803-1", "uniprot_id": [ { "id": "GDIR1_BOVIN", "url": "https://www.uniprot.org/uniprot/P19803", "type": "external" } ], "mass": 23421.0, "length": 204, "protein_name": "Rho GDP-dissociation inhibitor 1", "gene_name": "ARHGDIA", "organism": "Bovine", "refseq_name": "rho GDP-dissociation inhibitor 1", "refseq_ac": [ { "id": "NP_788823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788823", "type": "external" } ], "gene_names_uniprotkb": "ARHGDIA", "gene_names_refseq": "ARHGDIA", "protein_names_uniprotkb": "Rho GDP-dissociation inhibitor 1; Rho GDI 1; Rho-GDI alpha", "protein_names_refseq": "Rho GDP dissociation inhibitor (GDI) alpha; rho GDI 1; rho GDP-dissociation inhibitor 1; rho-GDI alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:338054); (R-BTA-193634); (R-BTA-209563); (R-BTA-8980692); (R-BTA-9013106); (R-BTA-9013148); (R-BTA-9013404); (R-BTA-9013407); (R-BTA-9013408)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "15033930;15471984;18234179;2120668;22411835;9194563", "class_list": "", "function": "Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Increased expression of bovine Rho GDIalpha led to electrophysiological alterations that resulted in atrial arrhythmias and AV conduction abnormalities in transgenic mice, whereas ventricular contractile function was largely preserved., [RefSeq, PubMed]; Rho GDP association inhibitor (GDI) alpha- mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival., [RefSeq, PubMed]; That inhibition of Ca2+ channel activity by overexpression of Rho GDI-alpha is mediated by inhibition of RhoA in cardiac myocytes, [RefSeq, PubMed]; The effective GDI displacement that is observed is caused by inhibition of reformation of Rab:GDI complexes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBA9", "ec_number_list": [], "go_molecular_function": "GO:0005094 Rho GDP-dissociation inhibitor activity;GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0001772 immunological synapse;GO:0005634 nucleus;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0071526 semaphorin-plexin signaling pathway;GO:0007266 Rho protein signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0098693 regulation of synaptic vesicle cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P19803-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20072-1", "uniprot_id": [ { "id": "ANXA7_BOVIN", "url": "https://www.uniprot.org/uniprot/P20072", "type": "external" } ], "mass": 49940.0, "length": 463, "protein_name": "Annexin A7", "gene_name": "ANXA7", "organism": "Bovine", "refseq_name": "annexin A7", "refseq_ac": [ { "id": "NP_001069459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069459", "type": "external" } ], "gene_names_uniprotkb": "ANXA7; ANX7", "gene_names_refseq": "ANX7; ANXA7", "protein_names_uniprotkb": "Annexin A7; Annexin VII; Annexin-7; Synexin", "protein_names_refseq": "annexin A7; annexin VII; annexin-7; synexin", "tax_id": 9913, "disease": "", "pathway": " (bta:533360)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12438137;2967699", "class_list": "", "function": "Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Demonstration that ANX7 is a substrate for botulinum toxin type C, both in vitro and in permeabilized chromaffin cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZ88", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding;GO:0005178 integrin binding;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0012506 vesicle membrane;GO:0042584 chromaffin granule membrane", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0030855 epithelial cell differentiation;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P20072-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20427-1", "uniprot_id": [ { "id": "CSK22_BOVIN", "url": "https://www.uniprot.org/uniprot/P20427", "type": "external" } ], "mass": 41270.0, "length": 350, "protein_name": "Casein kinase II subunit alpha'", "gene_name": "CSNK2A2", "organism": "Bovine", "refseq_name": "casein kinase II subunit alpha'", "refseq_ac": [ { "id": "NP_777061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777061", "type": "external" } ], "gene_names_uniprotkb": "CSNK2A2", "gene_names_refseq": "CSNK2A2", "protein_names_uniprotkb": "Casein kinase II subunit alpha'; 2.7.11.1; CK II alpha'", "protein_names_refseq": "CK II alpha'; casein kinase 2, alpha prime polypeptide; casein kinase II subunit alpha'", "tax_id": 9913, "disease": "", "pathway": " (bta:282420)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2159007", "class_list": "", "function": "Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. May phosphorylate histone H2A on 'Ser-1'., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005956 protein kinase CK2 complex", "go_biological_process": "GO:1905818 regulation of chromosome separation;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0006915 apoptotic process;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P20427-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21671-1", "uniprot_id": [ { "id": "PLCD4_BOVIN", "url": "https://www.uniprot.org/uniprot/P21671", "type": "external" } ], "mass": 90581.0, "length": 791, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4", "gene_name": "PLCD4", "organism": "Bovine", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4", "refseq_ac": [ { "id": "NP_001039954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039954", "type": "external" } ], "gene_names_uniprotkb": "PLCD4; PLCD2", "gene_names_refseq": "PLCD4", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; 3.1.4.11; PLC-85; PLC-delta-2; PLC-delta-4; Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-2; Phospholipase C-delta-4", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; PLC-85; PLC-delta-2; PLC-delta-4; phosphoinositide phospholipase C-delta-4; phospholipase C-delta-2", "tax_id": 9913, "disease": "", "pathway": " (bta:540771)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15219862;2753038", "class_list": "", "function": "Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KIZ7", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding;GO:0001965 G-protein alpha-subunit binding;GO:0120548 phosphatidylinositol phospholipase C activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P21671-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22444-1", "uniprot_id": [ { "id": "BMP3_BOVIN", "url": "https://www.uniprot.org/uniprot/P22444", "type": "external" } ], "mass": 53501.0, "length": 475, "protein_name": "Bone morphogenetic protein 3", "gene_name": "BMP3", "organism": "Bovine", "refseq_name": "bone morphogenetic protein 3 precursor", "refseq_ac": [ { "id": "NP_001179197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179197", "type": "external" } ], "gene_names_uniprotkb": "BMP3", "gene_names_refseq": "BMP-3; BMP3", "protein_names_uniprotkb": "Bone morphogenetic protein 3; BMP-3; Osteogenin", "protein_names_refseq": "bone morphogenetic protein 3 (osteogenic); bone morphogenetic protein 3 precursor; osteogenin", "tax_id": 9913, "disease": "", "pathway": " (bta:539527)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2547759", "class_list": "", "function": "Induces cartilage and bone formation., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0001649 osteoblast differentiation;GO:0051216 cartilage development;GO:0030279 negative regulation of ossification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P22444-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22600-1", "uniprot_id": [ { "id": "HEMH_BOVIN", "url": "https://www.uniprot.org/uniprot/P22600", "type": "external" } ], "mass": 46935.0, "length": 416, "protein_name": "Ferrochelatase, mitochondrial", "gene_name": "FECH", "organism": "Bovine", "refseq_name": "ferrochelatase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776479", "type": "external" } ], "gene_names_uniprotkb": "FECH", "gene_names_refseq": "FECH", "protein_names_uniprotkb": "Ferrochelatase, mitochondrial; 4.98.1.1; Heme synthase; Protoheme ferro-lyase", "protein_names_refseq": "ferrochelatase, mitochondrial precursor; ferrochelatase, mitochondrial; heme synthase; heme synthetase; protoheme ferro-lyase; protoporphyria", "tax_id": 9913, "disease": "", "pathway": " (bta:281158); (R-BTA-189451); (R-BTA-9837999)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1704134;2246229;7640290", "class_list": "", "function": "Catalyzes the ferrous insertion into protoporphyrin IX and participates in the terminal step in the heme biosynthetic pathway., [UniProtKB, UniProtKB]; Catalyzes the ferrous insertion into protoporphyrin IX., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0004325 ferrochelatase activity;GO:0042803 protein homodimerization activity;GO:0030350 iron-responsive element binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0046501 protoporphyrinogen IX metabolic process;GO:0006785 heme B biosynthetic process;GO:0006784 heme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P22600-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24275-1", "uniprot_id": [ { "id": "AKAP5_BOVIN", "url": "https://www.uniprot.org/uniprot/P24275", "type": "external" } ], "mass": 47878.0, "length": 428, "protein_name": "A-kinase anchor protein 5", "gene_name": "AKAP5", "organism": "Bovine", "refseq_name": "A-kinase anchor protein 5", "refseq_ac": [ { "id": "NP_776661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776661", "type": "external" } ], "gene_names_uniprotkb": "AKAP5; AKAP75", "gene_names_refseq": "AKAP5; AKAP75; AKAP; P75", "protein_names_uniprotkb": "A-kinase anchor protein 5; A-kinase anchor protein 75 kDa; AKAP 75; AKAP-5; P75; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein", "protein_names_refseq": "A kinase (PRKA) anchor protein 5; A-kinase anchor protein 5; A-kinase anchor protein 75 kDa; AKAP 75; AKAP-5; anchor protein regulatory subunit (AKAP75); cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281612)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16322564;1733921;2016323", "class_list": "", "function": "Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses. Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses., [UniProtKB, UniProtKB]; The C-helix of protein kinase A inhibitory regulatory subunit is identified as a highly dynamic switch which relays cyclic AMP binding to the helical catalytic-subunit binding regions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0060090 molecular adaptor activity;GO:0005516 calmodulin binding;GO:0008179 adenylate cyclase binding;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0045121 membrane raft;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007194 negative regulation of adenylate cyclase activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P24275-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25104-1", "uniprot_id": [ { "id": "AGTR1_BOVIN", "url": "https://www.uniprot.org/uniprot/P25104", "type": "external" } ], "mass": 41088.0, "length": 359, "protein_name": "Type-1 angiotensin II receptor", "gene_name": "AGTR1", "organism": "Bovine", "refseq_name": "type-1 angiotensin II receptor", "refseq_ac": [ { "id": "NP_776658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776658", "type": "external" } ], "gene_names_uniprotkb": "AGTR1", "gene_names_refseq": "AGTR1", "protein_names_uniprotkb": "Type-1 angiotensin II receptor; AT1 receptor; Angiotensin II type-1 receptor", "protein_names_refseq": "AT1 receptor; AT1; angiotensin II receptor 1; angiotensin II type-1 receptor; angiotensin receptor 1; type-1 angiotensin II receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281607); (R-BTA-375276); (R-BTA-416476); (R-BTA-8856825); (R-BTA-8856828)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "15315905;17494631;2041569", "class_list": "", "function": "Angiotensin II (ANGII) inhibits adrenocortical cell KCNK2 in an ATP dependent, PLC/PKC independent manner., [RefSeq, PubMed]; Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:2041569). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed:2041569)., [UniProtKB, PubMed]; These results identify bTREK-1 K(+) channels as a pivotal control point where ANG II receptor activation is transduced to depolarization-dependent Ca(2+) entry and aldosterone secretion., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031711 bradykinin receptor binding;GO:0001596 angiotensin type I receptor activity;GO:0004945 angiotensin type II receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0001822 kidney development;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P25104-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25326-1", "uniprot_id": [ { "id": "CATS_BOVIN", "url": "https://www.uniprot.org/uniprot/P25326", "type": "external" } ], "mass": 37176.0, "length": 331, "protein_name": "Cathepsin S", "gene_name": "CTSS", "organism": "Bovine", "refseq_name": "cathepsin S precursor", "refseq_ac": [ { "id": "NP_001028787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028787", "type": "external" } ], "gene_names_uniprotkb": "CTSS", "gene_names_refseq": "CTSS", "protein_names_uniprotkb": "Cathepsin S; 3.4.22.27", "protein_names_refseq": "cathepsin S precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:327711); (R-BTA-1474228); (R-BTA-1679131); (R-BTA-2132295); (R-BTA-6798695)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "1515067;1864368;2044774;21585286;2604727;30573663", "class_list": "", "function": "The cathepsin S deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease., [RefSeq, PubMed]; Thiol protease (By similarity). Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity). Elicits itch by mediating cleavage and activation of MRGPRX1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0V8", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.22.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.34", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P25326-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25508-1", "uniprot_id": [ { "id": "COCA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P25508", "type": "external" } ], "mass": 8063.0, "length": 86, "protein_name": "Collagen alpha-1(XII) chain", "gene_name": "COL12A1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COL12A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(XII) chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3133242", "class_list": "", "function": "Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P25508-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26884-1", "uniprot_id": [ { "id": "FKBP3_BOVIN", "url": "https://www.uniprot.org/uniprot/P26884", "type": "external" } ], "mass": 25191.0, "length": 224, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP3", "gene_name": "FKBP3", "organism": "Bovine", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP3", "refseq_ac": [ { "id": "NP_001033201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033201", "type": "external" } ], "gene_names_uniprotkb": "FKBP3", "gene_names_refseq": "FKBP-3; FKBP3", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP3; 25 kDa FK506-binding protein; 25 kDa FKBP; 5.2.1.8; FK506-binding protein 3; FKBP-25; FKBP-3; Immunophilin FKBP25; PPIase FKBP3; Rapamycin-selective 25 kDa immunophilin; Rotamase", "protein_names_refseq": "25 kDa FK506-binding protein; 25 kDa FKBP; FK506 binding protein 3, 25kDa; FK506-binding protein 3; FKBP-25; PPIase FKBP3; immunophilin FKBP25; peptidyl-prolyl cis-trans isomerase FKBP3; rapamycin-selective 25 kDa immunophilin; rotamase", "tax_id": 9913, "disease": "", "pathway": " (bta:515069)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1371698", "class_list": "", "function": "FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32KT9", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P26884-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26892-1", "uniprot_id": [ { "id": "IL6_BOVIN", "url": "https://www.uniprot.org/uniprot/P26892", "type": "external" } ], "mass": 23759.0, "length": 208, "protein_name": "Interleukin-6", "gene_name": "IL6", "organism": "Bovine", "refseq_name": "interleukin-6 precursor", "refseq_ac": [ { "id": "NP_776348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776348", "type": "external" } ], "gene_names_uniprotkb": "IL6", "gene_names_refseq": "IL6", "protein_names_uniprotkb": "Interleukin-6; IL-6", "protein_names_refseq": "IL-6; interleukin 6 (interferon, beta 2); interleukin-6 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280826); (R-BTA-1059683); (R-BTA-110056); (R-BTA-381426); (R-BTA-8957275); (R-BTA-9958825)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "12419823;1446077;17530193;19144032;24186266;24555796;25740541;26813342;33430761", "class_list": "", "function": "Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells., [UniProtKB, UniProtKB]; Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected., [RefSeq, PubMed]; IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Interleukin-6 promotes primitive endoderm development in bovine blastocysts. Publication Status: Online-Only, [RefSeq, PubMed]; Results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes., [RefSeq, PubMed]; STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells., [RefSeq, PubMed]; Testicular IL-1 alpha and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period., [RefSeq, PubMed]; The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV., [RefSeq, PubMed]; The results showed that the expression of TNF-alpha, iNOS, and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6, IL-12], [RefSeq, PubMed]; When a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A9QWQ9;Q08DT2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005138 interleukin-6 receptor binding", "go_cellular_component": "GO:0005896 interleukin-6 receptor complex;GO:0005615 extracellular space", "go_biological_process": "GO:0002384 hepatic immune response;GO:0072574 hepatocyte proliferation;GO:0060252 positive regulation of glial cell proliferation;GO:0006954 inflammatory response;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P26892-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27718-1", "uniprot_id": [ { "id": "DDC_BOVIN", "url": "https://www.uniprot.org/uniprot/P27718", "type": "external" } ], "mass": 54294.0, "length": 487, "protein_name": "Aromatic-L-amino-acid decarboxylase", "gene_name": "DDC", "organism": "Bovine", "refseq_name": "aromatic-L-amino-acid decarboxylase", "refseq_ac": [ { "id": "NP_776332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776332", "type": "external" } ], "gene_names_uniprotkb": "DDC", "gene_names_refseq": "DDC", "protein_names_uniprotkb": "Aromatic-L-amino-acid decarboxylase; 4.1.1.28; AADC; DDC; DOPA decarboxylase", "protein_names_refseq": "AADC; aromatic-L-amino-acid decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase)", "tax_id": 9913, "disease": "", "pathway": " (bta:280762)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16305752;2166204", "class_list": "", "function": "Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8S3", "ec_number_list": [ { "id": "4.1.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.28", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004058 aromatic-L-amino-acid decarboxylase activity;GO:0036468 L-dopa decarboxylase activity;GO:0036467 5-hydroxy-L-tryptophan decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042416 dopamine biosynthetic process;GO:0006584 catecholamine metabolic process;GO:0006520 amino acid metabolic process;GO:0042427 serotonin biosynthetic process;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P27718-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28291-1", "uniprot_id": [ { "id": "CCL2_BOVIN", "url": "https://www.uniprot.org/uniprot/P28291", "type": "external" } ], "mass": 11114.0, "length": 99, "protein_name": "C-C motif chemokine 2", "gene_name": "CCL2", "organism": "Bovine", "refseq_name": "C-C motif chemokine 2 precursor", "refseq_ac": [ { "id": "NP_776431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776431", "type": "external" } ], "gene_names_uniprotkb": "CCL2; SCYA2", "gene_names_refseq": "CCL2; MCP-1A; MCP-1; MCP1A; MCP1; SCYA2", "protein_names_uniprotkb": "C-C motif chemokine 2; Acidic seminal fluid protein; MCP-1A; MCP-1; Monocyte chemotactic protein 1A; Small-inducible cytokine A2", "protein_names_refseq": "C-C motif chemokine 2 precursor; C-C motif chemokine 2; acidic seminal fluid protein; monocyte chemoattractant protein 1; monocyte chemotactic protein 1A; small-inducible cytokine A2", "tax_id": 9913, "disease": "", "pathway": " (bta:281043); (R-BTA-380108)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "1543494;15659710;1721821;24813219;25020170;28816360;32122602;38438567;8060303", "class_list": "", "function": "Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; C-C motif chemokine ligand 2 regulates prostaglandin synthesis and embryo attachment of the bovine endometrium during implantation., [RefSeq, PubMed]; CCL2 plays a pivotal role in reproductive tissues and may support maternal-fetal interface to improve efficiency of pregnancy., [RefSeq, PubMed]; Immune cells and endothelial cells can interact cooperatively to increase CCL2 secretion in the corpus luteum, [RefSeq, PubMed]; Resence of type 2 diabetes negatively affects the work of cytokines and markers of fibrosis, as evidenced by higher levels of interleukin-1beta and monocyte chemoattractant protein-1, compared with patients without diabetes, [RefSeq, PubMed]; Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2) genes., [RefSeq, PubMed]; The chemokines CCL2 and CXCL10 produced by bovine endometrial epithelial cells induce migration of bovine B lymphocytes, contributing to transuterine transmission of BLV infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9QWP7", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P28291-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30367-1", "uniprot_id": [ { "id": "IL4_BOVIN", "url": "https://www.uniprot.org/uniprot/P30367", "type": "external" } ], "mass": 15119.0, "length": 135, "protein_name": "Interleukin-4", "gene_name": "IL4", "organism": "Bovine", "refseq_name": "interleukin-4 precursor", "refseq_ac": [ { "id": "NP_776346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776346", "type": "external" } ], "gene_names_uniprotkb": "IL4", "gene_names_refseq": "BSF-1; IL-4; IL4", "protein_names_uniprotkb": "Interleukin-4; B-cell stimulatory factor 1; BSF-1; IL-4; Lymphocyte stimulatory factor 1", "protein_names_refseq": "B-cell stimulatory factor 1; interleukin-4 precursor; lymphocyte stimulatory factor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:280824); (R-BTA-6785807)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1601309;18055157;18322231;23814356;7626886", "class_list": "", "function": "IL-4 may play a role in coordinating the adrenal response to inflammatory stress., [RefSeq, PubMed]; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4., [UniProtKB, UniProtKB]; T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions., [RefSeq, PubMed]; These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma occurring after parturition and an increase in IL-4 production before calving., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A9QWQ7", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005136 interleukin-4 receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus;GO:0010633 negative regulation of epithelial cell migration;GO:0032736 positive regulation of interleukin-13 production;GO:0035771 interleukin-4-mediated signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P30367-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30671-1", "uniprot_id": [ { "id": "GBG7_BOVIN", "url": "https://www.uniprot.org/uniprot/P30671", "type": "external" } ], "mass": 7552.0, "length": 68, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7", "gene_name": "GNG7", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7", "refseq_ac": [ { "id": "NP_001106785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106785", "type": "external" } ], "gene_names_uniprotkb": "GNG7; GNGT7", "gene_names_refseq": "GNG7; HG3B", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7; G gamma-II", "protein_names_refseq": "g gamma-II; gamma-II; guanine nucleotide binding protein (G protein), gamma 7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7; heterotrimeric guanine nucleotide-binding protein 3B", "tax_id": 9913, "disease": "", "pathway": " (bta:618399); (R-BTA-1296041); (R-BTA-202040); (R-BTA-381676); (R-BTA-392170); (R-BTA-392451); (R-BTA-392851); (R-BTA-400042); (R-BTA-4086398); (R-BTA-416476); (R-BTA-416482); (R-BTA-418217); (R-BTA-418555); (R-BTA-418592); (R-BTA-418594); (R-BTA-418597); (R-BTA-420092); (R-BTA-428930); (R-BTA-432040); (R-BTA-456926); (R-BTA-500657); (R-BTA-6814122); (R-BTA-8964315); (R-BTA-8964616); (R-BTA-9009391); (R-BTA-9856530); (R-BTA-997272)", "pathway_count": 27, "publication_count": 2, "publication_id_list": "1385432;8439334", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilization of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7MB87", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0045202 synapse;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P30671-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30932-1", "uniprot_id": [ { "id": "CD9_BOVIN", "url": "https://www.uniprot.org/uniprot/P30932", "type": "external" } ], "mass": 25258.0, "length": 226, "protein_name": "CD9 antigen", "gene_name": "CD9", "organism": "Bovine", "refseq_name": "CD9 antigen", "refseq_ac": [ { "id": "NP_776325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776325", "type": "external" } ], "gene_names_uniprotkb": "CD9", "gene_names_refseq": "CD9", "protein_names_uniprotkb": "CD9 antigen", "protein_names_refseq": "CD9 antigen (p24); CD9 antigen", "tax_id": 9913, "disease": "", "pathway": " (bta:280746); (R-BTA-114608); (R-BTA-1300645)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1339429;17912457;19293563;23572435;30452988", "class_list": "", "function": "CD9 present on bovine matured oocytes is involved in sperm-oocyte interaction during fertilization., [RefSeq, PubMed]; Immortalized microvascular endothelial cells of the bovine retina express members of the tetraspanin family of which CD9 was demonstrated to have a function in migration and adhesion of these cells., [RefSeq, PubMed]; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (By similarity). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Tests showed that the vitrification/warming procedures significantly decreased CD9 expression at the mRNA and protein levels, and changed the CD9 distribution pattern in bovine oocytes., [RefSeq, PubMed]; The aim of this study was to compare the localization of CD9 and CD81 tetraspanins during oocyte maturation and early development of the embryos in bovine and porcine model., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6QLK0", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070062 extracellular exosome", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007155 cell adhesion;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0008285 negative regulation of cell population proliferation;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P30932-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31322-1", "uniprot_id": [ { "id": "KAP3_BOVIN", "url": "https://www.uniprot.org/uniprot/P31322", "type": "external" } ], "mass": 46336.0, "length": 418, "protein_name": "cAMP-dependent protein kinase type II-beta regulatory subunit", "gene_name": "PRKAR2B", "organism": "Bovine", "refseq_name": "cAMP-dependent protein kinase type II-beta regulatory subunit", "refseq_ac": [ { "id": "NP_777074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777074", "type": "external" } ], "gene_names_uniprotkb": "PRKAR2B", "gene_names_refseq": "PRKAR2B", "protein_names_uniprotkb": "cAMP-dependent protein kinase type II-beta regulatory subunit", "protein_names_refseq": "cAMP-dependent protein kinase type II-beta regulatory subunit; protein kinase, cAMP-dependent, regulatory, type II, beta", "tax_id": 9913, "disease": "", "pathway": " (bta:282463)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15046986;2254332", "class_list": "", "function": "Angle X-ray scattering studies indicate that the RIalpha, RIIalpha, and RIIbeta homodimers differ markedly in overall shape, despite extensive sequence homology and similar molecular masses, [RefSeq, PubMed]; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P31322-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31717-1", "uniprot_id": [ { "id": "NMT1_BOVIN", "url": "https://www.uniprot.org/uniprot/P31717", "type": "external" } ], "mass": 56919.0, "length": 497, "protein_name": "Glycylpeptide N-tetradecanoyltransferase 1", "gene_name": "NMT1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NMT1; NMT", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycylpeptide N-tetradecanoyltransferase 1; 2.3.1.97; Myristoyl-CoA:protein N-myristoyltransferase 1; NMT 1; Peptide N-myristoyltransferase 1; Type I N-myristoyltransferase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8452528", "class_list": "", "function": "Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9N177", "ec_number_list": [ { "id": "2.3.1.97", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.97", "type": "external" } ], "go_molecular_function": "GO:0004379 glycylpeptide N-tetradecanoyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0018008 N-terminal peptidyl-glycine N-myristoylation;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P31717-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31754-1", "uniprot_id": [ { "id": "UMPS_BOVIN", "url": "https://www.uniprot.org/uniprot/P31754", "type": "external" } ], "mass": 52229.0, "length": 480, "protein_name": "Uridine 5'-monophosphate synthase", "gene_name": "UMPS", "organism": "Bovine", "refseq_name": "uridine 5'-monophosphate synthase", "refseq_ac": [ { "id": "NP_803474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803474", "type": "external" } ], "gene_names_uniprotkb": "UMPS", "gene_names_refseq": "UMPS", "protein_names_uniprotkb": "Uridine 5'-monophosphate synthase; OMPdecase; UMP synthase", "protein_names_refseq": "UMP synthase; mutant uridine monophosphate synthase; orotate phosphoribosyl transferase and orotidine-5'-decarboxylase; uridine 5'-monophosphate synthase; uridine monophophate synthase", "tax_id": 9913, "disease": "", "pathway": " (bta:281568)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8444356;8486364", "class_list": "", "function": "Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KHV1", "ec_number_list": [ { "id": "2.4.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.10", "type": "external" }, { "id": "4.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.23", "type": "external" } ], "go_molecular_function": "GO:0004588 orotate phosphoribosyltransferase activity;GO:0004590 orotidine-5'-phosphate decarboxylase activity", "go_cellular_component": "", "go_biological_process": "GO:0006222 UMP biosynthetic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205 'de novo' UMP biosynthetic process;GO:0019856 pyrimidine nucleobase biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P31754-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33046-1", "uniprot_id": [ { "id": "CTHL4_BOVIN", "url": "https://www.uniprot.org/uniprot/P33046", "type": "external" } ], "mass": 16479.0, "length": 144, "protein_name": "Cathelicidin-4", "gene_name": "CATHL4", "organism": "Bovine", "refseq_name": "cathelicidin-4 precursor", "refseq_ac": [ { "id": "NP_777252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777252", "type": "external" } ], "gene_names_uniprotkb": "CATHL4", "gene_names_refseq": "CATHL4", "protein_names_uniprotkb": "Cathelicidin-4; Indolicidin", "protein_names_refseq": "cathelicidin-4 precursor; indolicidin", "tax_id": 9913, "disease": "", "pathway": " (bta:282166); (R-BTA-6798695); (R-BTA-6803157)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11123901;12745074;1520337;1537821;25935286", "class_list": "", "function": "Potent microbicidal activity; active against S.aureus and E.coli., [UniProtKB]; Proline residues are necessary for interaction of indolicidin with lipopolysaccharides; the third and tenth proline residues in indolicidin are responsible for its antimicrobial activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KN14", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P33046-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33545-1", "uniprot_id": [ { "id": "DSC2_BOVIN", "url": "https://www.uniprot.org/uniprot/P33545", "type": "external" } ], "mass": 95875.0, "length": 863, "protein_name": "Desmocollin-2", "gene_name": "DSC2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DSC2", "gene_names_refseq": "", "protein_names_uniprotkb": "Desmocollin-2; Epithelial type 2 desmocollin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1729705", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (By similarity). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (By similarity). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (By similarity). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030057 desmosome", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P33545-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33567-1", "uniprot_id": [ { "id": "SYUB_BOVIN", "url": "https://www.uniprot.org/uniprot/P33567", "type": "external" } ], "mass": 14277.0, "length": 134, "protein_name": "Beta-synuclein", "gene_name": "SNCB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SNCB", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-synuclein; 14 kDa brain-specific protein; PNP 14; Phosphoneuroprotein 14", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2230807;8223629", "class_list": "", "function": "May be involved in neuronal plasticity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1903136 cuprous ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0050808 synapse organization;GO:0007268 chemical synaptic transmission;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P33567-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34933-1", "uniprot_id": [ { "id": "HSP72_BOVIN", "url": "https://www.uniprot.org/uniprot/P34933", "type": "external" } ], "mass": 69740.0, "length": 636, "protein_name": "Heat shock-related 70 kDa protein 2", "gene_name": "HSPA2", "organism": "Bovine", "refseq_name": "heat shock-related 70 kDa protein 2", "refseq_ac": [ { "id": "NP_776769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776769", "type": "external" } ], "gene_names_uniprotkb": "HSPA2; HSP70-3; HSPA3", "gene_names_refseq": "HSP70.3; HSPA2; HSPA3", "protein_names_uniprotkb": "Heat shock-related 70 kDa protein 2; HSP70.3; Heat shock 70 kDa protein 3", "protein_names_refseq": "heat shock 70 kD protein 3; heat shock 70 kDa protein 3; heat shock 70kDa protein 1A; heat shock 70kDa protein 3; heat shock-related 70 kDa protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281827)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1478667", "class_list": "", "function": "Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3MHP7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0036128 CatSper complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009409 response to cold;GO:0030154 cell differentiation;GO:0009408 response to heat;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P34933-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34955-1", "uniprot_id": [ { "id": "A1AT_BOVIN", "url": "https://www.uniprot.org/uniprot/P34955", "type": "external" } ], "mass": 46104.0, "length": 416, "protein_name": "Alpha-1-antiproteinase", "gene_name": "SERPINA1", "organism": "Bovine", "refseq_name": "alpha-1-antiproteinase precursor", "refseq_ac": [ { "id": "NP_776307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776307", "type": "external" } ], "gene_names_uniprotkb": "SERPINA1; PI", "gene_names_refseq": "PI; SERPINA1", "protein_names_uniprotkb": "Alpha-1-antiproteinase; Alpha-1-antitrypsin; Alpha-1-proteinase inhibitor; Serpin A1", "protein_names_refseq": "alpha-1-antiproteinase precursor; alpha-1-antiproteinase; alpha-1-antitrypsin; alpha-1-proteinase inhibitor; protease inhibitor 1 (anti-elastase, antitrypsin, alpha-1); serine (or cysteine) proteinase inhibitor, clade A (alpha-1antiproteinase, antitrypsin), member 1; serine proteinase inhibitor, clade A, member 1; serpin A1", "tax_id": 9913, "disease": "", "pathway": " (bta:280699); (R-BTA-114608); (R-BTA-204005); (R-BTA-381426); (R-BTA-5694530); (R-BTA-6798695); (R-BTA-8957275)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "11057674;15240697;1562597;15674733;16305752;16393994;19801983;26495903;8056747;8268130;8746565", "class_list": "", "function": "Comparisons of the expression patterns of cattle fetuses and their dams show that the PI gene is biallelically expressed in fetuses and predominantly monoallelically expressed in the dams., [RefSeq, PubMed]; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZS3", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P34955-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34974-1", "uniprot_id": [ { "id": "ACTHR_BOVIN", "url": "https://www.uniprot.org/uniprot/P34974", "type": "external" } ], "mass": 33293.0, "length": 297, "protein_name": "Adrenocorticotropic hormone receptor", "gene_name": "MC2R", "organism": "Bovine", "refseq_name": "adrenocorticotropic hormone receptor", "refseq_ac": [ { "id": "NP_776534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776534", "type": "external" } ], "gene_names_uniprotkb": "MC2R", "gene_names_refseq": "MC2R", "protein_names_uniprotkb": "Adrenocorticotropic hormone receptor; ACTH receptor; ACTH-R; Adrenocorticotropin receptor; MC2-R; Melanocortin receptor 2", "protein_names_refseq": "ACTH receptor; ACTH-R; MC2-R; adrenocorticotropic hormone receptor; adrenocorticotropin receptor; melanocortin receptor 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281299); (R-BTA-375276); (R-BTA-418555)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8305507", "class_list": "", "function": "G protein-coupled receptor for corticotropin/ACTH, primarily expressed in adrenal cortex where it plays a key role in the regulation of adrenocortical function. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and activating the cAMP-dependent signaling pathway, the MAPK cascade as well as the PKA pathway, leading to steroidogenic factor 1/NR5A1-mediated transcriptional activation. Activation by ACTH facilitates the release of adrenal glucocorticoids, including cortisol and corticosterone (By similarity). In addition, MC2R is required for fetal and neonatal adrenal gland development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0046872 metal ion binding;GO:0004978 corticotropin receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P34974-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34993-1", "uniprot_id": [ { "id": "SSR2_BOVIN", "url": "https://www.uniprot.org/uniprot/P34993", "type": "external" } ], "mass": 41134.0, "length": 368, "protein_name": "Somatostatin receptor type 2", "gene_name": "SSTR2", "organism": "Bovine", "refseq_name": "somatostatin receptor type 2", "refseq_ac": [ { "id": "NP_776892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776892", "type": "external" } ], "gene_names_uniprotkb": "SSTR2", "gene_names_refseq": "SSTR2", "protein_names_uniprotkb": "Somatostatin receptor type 2; SRIF-1; SS-2-R; SS2-R; SS2R", "protein_names_refseq": "SRIF-1; SS-2-R; SS2-R; SS2R; somatostatin receptor type 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282083)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24530462", "class_list": "", "function": "Follicle-stimulating hormone regulates the SSTR2 protein expression in bovine granulosa cells., [RefSeq, PubMed]; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0071392 cellular response to estradiol stimulus;GO:0071385 cellular response to glucocorticoid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P34993-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35376-1", "uniprot_id": [ { "id": "FSHR_BOVIN", "url": "https://www.uniprot.org/uniprot/P35376", "type": "external" } ], "mass": 78085.0, "length": 695, "protein_name": "Follicle-stimulating hormone receptor", "gene_name": "FSHR", "organism": "Bovine", "refseq_name": "follicle-stimulating hormone receptor precursor", "refseq_ac": [ { "id": "NP_776486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776486", "type": "external" } ], "gene_names_uniprotkb": "FSHR", "gene_names_refseq": "FSHR", "protein_names_uniprotkb": "Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor", "protein_names_refseq": "FSH-R; follicle-stimulating hormone receptor precursor; follitropin receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281172)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12782408;16481595;22670622;24668630;25454493;26845856;7826612", "class_list": "", "function": "Dominant follicles experience a reduction in FSH dependence (diminished expression of FSHR), but acquire increased LH dependence (enhanced expression of LHCGR) as they grow during the low FSH milieu of follicular waves., [RefSeq, PubMed]; G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways., [UniProtKB, UniProtKB]; Granulosa cell clustering is accompanied by marked increases in FSHr, IGF-1r, and p450 arom expression, and precedes induction and subsequent peak E2 production, [RefSeq, PubMed]; INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS, [RefSeq, PubMed]; Specific alleles of the bovine FSHR gene are associated with variations in embryo yield and in the number of unfertilised oocytes., [RefSeq, PubMed]; The expression of FSHR mRNA in granulosa cells was highest in small antral follicles, then decreased significantly as follicles increased in size, and was lowest in cysts., [RefSeq, PubMed]; Transfer. We conclude that variation at these loci of the FSHR gene has no significant effect on pregnancy rates in Luxi cattle. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004963 follicle-stimulating hormone receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P35376-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35507-1", "uniprot_id": [ { "id": "KC1B_BOVIN", "url": "https://www.uniprot.org/uniprot/P35507", "type": "external" } ], "mass": 38754.0, "length": 336, "protein_name": "Casein kinase I isoform beta", "gene_name": "CSNK1B", "organism": "Bovine", "refseq_name": "casein kinase I isoform beta", "refseq_ac": [ { "id": "NP_001091628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091628", "type": "external" } ], "gene_names_uniprotkb": "CSNK1B", "gene_names_refseq": "CSNK1B", "protein_names_uniprotkb": "Casein kinase I isoform beta; 2.7.11.1; CKI-beta", "protein_names_refseq": "CKI-beta; casein kinase I isoform beta", "tax_id": 9913, "disease": "", "pathway": " (bta:785423)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1946367", "class_list": "", "function": "Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KMY0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0018105 peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35507-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35509-1", "uniprot_id": [ { "id": "KC1G3_BOVIN", "url": "https://www.uniprot.org/uniprot/P35509", "type": "external" } ], "mass": 31510.0, "length": 276, "protein_name": "Casein kinase I isoform gamma-3", "gene_name": "CSNK1G3", "organism": "Bovine", "refseq_name": "casein kinase I isoform gamma-3", "refseq_ac": [ { "id": "NP_001098799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098799", "type": "external" } ], "gene_names_uniprotkb": "CSNK1G3", "gene_names_refseq": "CSNK1G3", "protein_names_uniprotkb": "Casein kinase I isoform gamma-3; 2.7.11.1; CKI-gamma 3", "protein_names_refseq": "CKI-gamma 3; casein kinase I isoform gamma-3; casein kinase I-gamma", "tax_id": 9913, "disease": "", "pathway": " (bta:407190)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1946367", "class_list": "", "function": "Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0032880 regulation of protein localization;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35509-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35541-1", "uniprot_id": [ { "id": "SAA_BOVIN", "url": "https://www.uniprot.org/uniprot/P35541", "type": "external" } ], "mass": 14516.0, "length": 130, "protein_name": "Serum amyloid A protein", "gene_name": "SAA1", "organism": "Bovine", "refseq_name": "serum amyloid A protein precursor", "refseq_ac": [ { "id": "NP_001068728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068728", "type": "external" } ], "gene_names_uniprotkb": "SAA1; SAA", "gene_names_refseq": "SAA1; SAA2; SAA", "protein_names_uniprotkb": "Serum amyloid A protein; Amyloid fibril protein AA; SAA", "protein_names_refseq": "serum amyloid A protein precursor; serum amyloid A protein", "tax_id": 9913, "disease": "", "pathway": " (bta:506412)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1738817;26373797;2909653;3393848;3791962", "class_list": "", "function": "Major acute phase reactant. Apolipoprotein of the HDL complex., [UniProtKB]; Polymorphisms in the SAA2 gene are associated with milk production traits in Chinese Holstein cows, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32L36", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P35541-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35833-1", "uniprot_id": [ { "id": "CSF3_BOVIN", "url": "https://www.uniprot.org/uniprot/P35833", "type": "external" } ], "mass": 21431.0, "length": 195, "protein_name": "Granulocyte colony-stimulating factor", "gene_name": "CSF3", "organism": "Bovine", "refseq_name": "granulocyte colony-stimulating factor precursor", "refseq_ac": [ { "id": "NP_776453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776453", "type": "external" } ], "gene_names_uniprotkb": "CSF3; GCSF", "gene_names_refseq": "CSF3", "protein_names_uniprotkb": "Granulocyte colony-stimulating factor; G-CSF", "protein_names_refseq": "G-CSF; colony stimulating factor 3 (granulocyte); granulocyte colony-stimulating factor precursor; granulocyte colony-stimulating factor", "tax_id": 9913, "disease": "", "pathway": " (bta:281096); (R-BTA-449836); (R-BTA-9674555); (R-BTA-9705462)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10690933;7504736", "class_list": "", "function": "Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9TV89", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005130 granulocyte colony-stimulating factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0071682 endocytic vesicle lumen", "go_biological_process": "GO:0006955 immune response;GO:0038158 granulocyte colony-stimulating factor signaling pathway;GO:0045639 positive regulation of myeloid cell differentiation;GO:0030225 macrophage differentiation;GO:0009891 positive regulation of biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35833-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37141-1", "uniprot_id": [ { "id": "GPX3_BOVIN", "url": "https://www.uniprot.org/uniprot/P37141", "type": "external" } ], "mass": 25663.0, "length": 226, "protein_name": "Glutathione peroxidase 3", "gene_name": "GPX3", "organism": "Bovine", "refseq_name": "glutathione peroxidase 3 precursor", "refseq_ac": [ { "id": "NP_776502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776502", "type": "external" } ], "gene_names_uniprotkb": "GPX3", "gene_names_refseq": "GPX3", "protein_names_uniprotkb": "Glutathione peroxidase 3; 1.11.1.9; GPx-3; GPx-P; GSHPx-3; GSHPx-P; Plasma glutathione peroxidase", "protein_names_refseq": "GPx-3; GPx-P; GSHPx-3; GSHPx-P; glutathione peroxidase 3 (plasma); glutathione peroxidase 3 precursor; plasma glutathione peroxidase", "tax_id": 9913, "disease": "", "pathway": " (bta:281210); (R-BTA-3299685)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "24186266;8262911", "class_list": "", "function": "Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected., [RefSeq, PubMed]; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione., [UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QPD6", "ec_number_list": [ { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004602 glutathione peroxidase activity;GO:0008430 selenium binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0042744 hydrogen peroxide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P37141-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41500-1", "uniprot_id": [ { "id": "ACYP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P41500", "type": "external" } ], "mass": 11432.0, "length": 101, "protein_name": "Acylphosphatase-1", "gene_name": "ACYP1", "organism": "Bovine", "refseq_name": "acylphosphatase-1", "refseq_ac": [ { "id": "NP_001039447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039447", "type": "external" } ], "gene_names_uniprotkb": "ACYP1; ACYPE", "gene_names_refseq": "ACYP1", "protein_names_uniprotkb": "Acylphosphatase-1; 3.6.1.7; Acylphosphatase, erythrocyte/testis isozyme; Acylphosphatase, organ-common type isozyme; Acylphosphate phosphohydrolase 1", "protein_names_refseq": "acylphosphatase 1, erythrocyte (common) type; acylphosphatase, erythrocyte/testis isozyme; acylphosphatase, organ-common type isozyme; acylphosphatase-1; acylphosphate phosphohydrolase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:507844)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "8142002;8262761;9016712", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1RMH2", "ec_number_list": [ { "id": "3.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.7", "type": "external" } ], "go_molecular_function": "GO:0003998 acylphosphatase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P41500-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41563-1", "uniprot_id": [ { "id": "IDH3A_BOVIN", "url": "https://www.uniprot.org/uniprot/P41563", "type": "external" } ], "mass": 39668.0, "length": 366, "protein_name": "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "gene_name": "IDH3A", "organism": "Bovine", "refseq_name": "isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor", "refseq_ac": [ { "id": "NP_777069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777069", "type": "external" } ], "gene_names_uniprotkb": "IDH3A", "gene_names_refseq": "BG1; IDH3A", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; 1.1.1.41; Isocitrate dehydrogenase subunits 3/4; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha", "protein_names_refseq": "NAD(+)-specific ICDH subunit alpha; isocitrate dehydrogenase (NAD(+)) 3 alpha; isocitrate dehydrogenase 3 (NAD(+)) alpha; isocitrate dehydrogenase 3 (NAD+) alpha; isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor; isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; isocitrate dehydrogenase subunits 3/4; isocitric dehydrogenase subunit alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:282446)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "215197;7654189", "class_list": "", "function": "Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0051287 NAD binding;GO:0004449 isocitrate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P41563-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41976-1", "uniprot_id": [ { "id": "SODM_BOVIN", "url": "https://www.uniprot.org/uniprot/P41976", "type": "external" } ], "mass": 24638.0, "length": 222, "protein_name": "Superoxide dismutase [Mn], mitochondrial", "gene_name": "SOD2", "organism": "Bovine", "refseq_name": "superoxide dismutase [Mn], mitochondrial precursor", "refseq_ac": [ { "id": "NP_963285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_963285", "type": "external" } ], "gene_names_uniprotkb": "SOD2", "gene_names_refseq": "MnSOD; SOD2X1; SOD2X2; SOD2", "protein_names_uniprotkb": "Superoxide dismutase [Mn], mitochondrial; 1.15.1.1", "protein_names_refseq": "manganous superoxide dismutase; superoxide dismutase 2, mitochondrial; superoxide dismutase [Mn], mitochondrial precursor; superoxide dismutase [Mn], mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:281496)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12658628;16305752;18434620;19228881;20197373;22823939;24186266;8292376", "class_list": "", "function": "Data suggest that during ectogenesis of blastocysts infected with bovine Herpesvirus type 5, expression of SOD2 (Mn) remains high indicating intense mitochondrial activity; this effect may be involved in inhibition of apoptosis in infected embryos. Publication Status: Online-Only, [RefSeq, PubMed]; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems., [UniProtKB, UniProtKB]; Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected., [RefSeq, PubMed]; Expression profile of SOD2 in follicles: oocytes (SOD2 restricted to ooplasm); cumulus cells (expressed some SOD2); follicular fluid (small follicles show increased amounts of SOD2 in comparison with large follicles), [RefSeq, PubMed]; Heart mitochondrial nucleoids contained SOD2, aortic endothelial cell mitochondrial nucleoids did not, [RefSeq, PubMed]; Shear stress influences spatial variations in vascular Mn-SOD expression with implications for LDL nitration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KJE8;Q5E9D2;Q862F8", "ec_number_list": [ { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0034599 cellular response to oxidative stress;GO:0006801 superoxide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P41976-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41985-1", "uniprot_id": [ { "id": "ACM2_BOVIN", "url": "https://www.uniprot.org/uniprot/P41985", "type": "external" } ], "mass": 51613.0, "length": 465, "protein_name": "Muscarinic acetylcholine receptor M2", "gene_name": "CHRM2", "organism": "Bovine", "refseq_name": "muscarinic acetylcholine receptor M2", "refseq_ac": [ { "id": "NP_001074202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074202", "type": "external" } ], "gene_names_uniprotkb": "CHRM2", "gene_names_refseq": "CHRM2", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M2", "protein_names_refseq": "muscarinic acetylcholine receptor M2", "tax_id": 9913, "disease": "", "pathway": " (bta:522170); (R-BTA-390648); (R-BTA-418594); (R-BTA-8856825); (R-BTA-8856828)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "18524769;26513204", "class_list": "", "function": "Airway M(2)Rs inhibit BK channels by a dual, Gbetagamma-mediated mechanism, a direct membrane-delimited interaction, and the activation of the phospholipase C/protein kinase C pathway, [RefSeq, PubMed]; Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CHRM2 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G proteins and mediates signaling by inhibiting adenylate cyclase activity., [UniProtKB, UniProtKB]; The original finding was the identification and purification of a vinpocetine and muscarinic antagonist-inhibited and CaM-activated plasma membrane-bound PDE1A, linked to M(2)AChR., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3Y686", "ec_number_list": [], "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P41985-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42916-1", "uniprot_id": [ { "id": "CL43_BOVIN", "url": "https://www.uniprot.org/uniprot/P42916", "type": "external" } ], "mass": 33616.0, "length": 321, "protein_name": "Collectin-43", "gene_name": "CL43", "organism": "Bovine", "refseq_name": "collectin-43 precursor", "refseq_ac": [ { "id": "NP_001002237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002237", "type": "external" } ], "gene_names_uniprotkb": "CL43", "gene_names_refseq": "CL-43; CL43", "protein_names_uniprotkb": "Collectin-43; 43 kDa collectin; CL-43", "protein_names_refseq": "43 kDa collectin; 43kDa collectin; collectin-43 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:431784)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12527419;17203746;8163480", "class_list": "", "function": "Lectin that binds to various sugars: mannose = ManNAc > fucose > GlcNAc > glucose = maltose > galactose > lactose > GalNAc. Could play a role in immune defense., [UniProtKB]; Molecular and genomic characteristics of collectin-43 (CL-43)., [RefSeq, PubMed]; REVIEW: The expression and characterization of conglutinin, CL-43, and CL-46 Review article, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZ84;Q8WMF4", "ec_number_list": [], "go_molecular_function": "GO:0005537 D-mannose binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005771 multivesicular body", "go_biological_process": "GO:0043129 surfactant homeostasis;GO:0050766 positive regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P42916-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42917-1", "uniprot_id": [ { "id": "INHBB_BOVIN", "url": "https://www.uniprot.org/uniprot/P42917", "type": "external" } ], "mass": 44897.0, "length": 408, "protein_name": "Inhibin beta B chain", "gene_name": "INHBB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "INHBB", "gene_names_refseq": "", "protein_names_uniprotkb": "Inhibin beta B chain; Activin beta-B chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7813465", "class_list": "", "function": "Activin B is a dimer of alpha and beta-B that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and wound healing. Signals through type I receptor ACVR1C, abundantly expressed in pancreatic beta cells, and type II receptors like ACVR2A. Upon ligand binding, these receptors phosphorylate intracellular signaling mediators SMAD2 and SMAD3, which form a complex with SMAD4, translocate to the nucleus, and regulate gene expression. Plays a crucial role in the induction of hepcidin by inflammation through activation of ACVR1C and subsequent phosphorylation of SMAD1/5/8 (By similarity). Regulates adipocyte lipid metabolism by decreasing non-esterified fatty acids and glycerol release and increases intracellular triglyceride content (By similarity). Stimulates wound healing by promoting cell migration and hair follicle regeneration through the JNK and ERK signaling pathways downstream of RHOA (By similarity)., [UniProtKB, UniProtKB]; Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0046882 negative regulation of follicle-stimulating hormone secretion;GO:0060279 positive regulation of ovulation;GO:0032869 cellular response to insulin stimulus;GO:0009611 response to wounding;GO:0046676 negative regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P42917-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43480-1", "uniprot_id": [ { "id": "IL10_BOVIN", "url": "https://www.uniprot.org/uniprot/P43480", "type": "external" } ], "mass": 20438.0, "length": 178, "protein_name": "Interleukin-10", "gene_name": "IL10", "organism": "Bovine", "refseq_name": "interleukin-10 precursor", "refseq_ac": [ { "id": "NP_776513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776513", "type": "external" } ], "gene_names_uniprotkb": "IL10", "gene_names_refseq": "IF2A; IL10", "protein_names_uniprotkb": "Interleukin-10; CSIF; Cytokine synthesis inhibitory factor; IL-10", "protein_names_refseq": "CSIF; IL-10; cytokine synthesis inhibitory factor; interferon 2A; interleukin-10 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281246)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21464967;22052007;25286662;28267404;8112615", "class_list": "", "function": "Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll like receptor activation. Publication Status: Online-Only, [RefSeq, PubMed]; IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes., [RefSeq, PubMed]; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF. Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Studied expression of Interleukin 10 (IL-10) in blood and milk samples of 25 healthy and 25 mastitic cows. Found IL-10 expression to be significantly higher in the blood and milk samples of mastitic cows compared to the healthy ones., [RefSeq, PubMed]; This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A9QWR2", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0006955 immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032689 negative regulation of type II interferon production;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P43480-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46159-1", "uniprot_id": [ { "id": "DEFB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P46159", "type": "external" } ], "mass": 4278.0, "length": 38, "protein_name": "Beta-defensin 1", "gene_name": "DEFB1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DEFB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-defensin 1; BNBD-1; BNDB-1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8454635", "class_list": "", "function": "Has bactericidal activity. Active against E.coli ML35 but not against S.aureus 502A (PubMed:8454635). May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0097225 sperm midpiece;GO:1990742 microvesicle", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P46159-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46161-1", "uniprot_id": [ { "id": "DEFB3_BOVIN", "url": "https://www.uniprot.org/uniprot/P46161", "type": "external" } ], "mass": 6325.0, "length": 57, "protein_name": "Beta-defensin 3", "gene_name": "DEFB3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DEFB3; BNDB3", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-defensin 3; BNBD-3; BNDB-3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "8454635;9488394", "class_list": "", "function": "Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P46161-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46167-1", "uniprot_id": [ { "id": "DEFB9_BOVIN", "url": "https://www.uniprot.org/uniprot/P46167", "type": "external" } ], "mass": 6049.0, "length": 55, "protein_name": "Beta-defensin 9", "gene_name": "DEFB9", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DEFB9; BNDB9", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-defensin 9; BNBD-9; BNDB-9", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "8454635;9488394", "class_list": "", "function": "Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O18814", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P46167-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46168-1", "uniprot_id": [ { "id": "DFB10_BOVIN", "url": "https://www.uniprot.org/uniprot/P46168", "type": "external" } ], "mass": 6928.0, "length": 62, "protein_name": "Beta-defensin 10", "gene_name": "DEFB10", "organism": "Bovine", "refseq_name": "beta-defensin 10 precursor", "refseq_ac": [ { "id": "NP_001108556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108556", "type": "external" } ], "gene_names_uniprotkb": "DEFB10; BNBD10", "gene_names_refseq": "BNBD10; DEFB10", "protein_names_uniprotkb": "Beta-defensin 10; BNBD-10; BNDB-10; Neutrophil beta-defensin 10", "protein_names_refseq": "BNBD-10; BNDB-10; beta-defensin 10 precursor; neutrophil beta-defensin 10", "tax_id": 9913, "disease": "", "pathway": " (bta:100141457)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15520886;26255277;8454635", "class_list": "", "function": "Bovine beta defensin 10 (DEFB10, BNBD10) mRNA is highly expressed in bovine neutrophils in response to lipopolysaccharide and is induced by 1,25-dihydroxyvitamin D3 in bovine monocytes., [RefSeq, PubMed]; Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5W5G8", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P46168-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46197-1", "uniprot_id": [ { "id": "ANPRB_BOVIN", "url": "https://www.uniprot.org/uniprot/P46197", "type": "external" } ], "mass": 117146.0, "length": 1047, "protein_name": "Atrial natriuretic peptide receptor 2", "gene_name": "NPR2", "organism": "Bovine", "refseq_name": "atrial natriuretic peptide receptor 2 precursor", "refseq_ac": [ { "id": "NP_776551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776551", "type": "external" } ], "gene_names_uniprotkb": "NPR2", "gene_names_refseq": "NPR2", "protein_names_uniprotkb": "Atrial natriuretic peptide receptor 2; 4.6.1.2; ANP-B; ANPR-B; Atrial natriuretic peptide receptor type B; GC-B; Guanylate cyclase B; NPR-B", "protein_names_refseq": "ANP-B; ANPR-B; ANPRB; GC-B; NPR-B; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor 2 precursor; atrial natriuretic peptide receptor 2; atrial natriuretic peptide receptor B; atrial natriuretic peptide receptor type B; atrionatriuretic peptide receptor B; guanylate cyclase B; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)", "tax_id": 9913, "disease": "", "pathway": " (bta:281357); (R-BTA-5578768)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16818377;17613728;17848634;7845391;8103329", "class_list": "", "function": "ATP is not required for the initial activation of natriuretic peptide receptor A and B, but does increase activity over time by reducing the apparent K(m) for GTP., [RefSeq, PubMed]; NPR-B is a highly regulated nano-machinery with domains acting at cross-talk points with other signal transducing cascades initiated by G protein-coupled receptors, [RefSeq, PubMed]; Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data support the existence of a novel transducing cascade, involving Galpha(q16)beta gamma coupling M(3)AChR to NPR-GC., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005929 cilium;GO:0045202 synapse", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0001503 ossification;GO:0030540 female genitalia development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P46197-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H2XJE8-1", "uniprot_id": [ { "id": "H2XJE8_BOVIN", "url": "https://www.uniprot.org/uniprot/H2XJE8", "type": "external" } ], "mass": 131689.0, "length": 1226, "protein_name": "AP2-associated protein kinase 1", "gene_name": "AAK1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AAK1", "gene_names_refseq": "", "protein_names_uniprotkb": "AP2-associated protein kinase 1; 2.7.11.1; Adaptor-associated kinase 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8856825); (R-BTA-8856828)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Preferentially, may phosphorylate substrates on threonine residues. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0035612 AP-2 adaptor complex binding;GO:0004672 protein kinase activity;GO:0005112 Notch binding", "go_cellular_component": "GO:0005905 clathrin-coated pit;GO:0098793 presynapse;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:2000369 regulation of clathrin-dependent endocytosis;GO:0032880 regulation of protein localization;GO:0045747 positive regulation of Notch signaling pathway;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "H2XJE8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E6B9-1", "uniprot_id": [ { "id": "G5E6B9_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E6B9", "type": "external" } ], "mass": 29042.0, "length": 253, "protein_name": "MHC class I-like antigen recognition-like domain-containing protein", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "MHC class I-like antigen recognition-like domain-containing protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E6B9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MYR5-1", "uniprot_id": [ { "id": "F1MYR5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MYR5", "type": "external" } ], "mass": 131266.0, "length": 1156, "protein_name": "Nitric oxide synthase", "gene_name": "NOS2", "organism": "Bovine", "refseq_name": "nitric oxide synthase, inducible isoform X1", "refseq_ac": [ { "id": "XP_024835413", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835413", "type": "external" } ], "gene_names_uniprotkb": "NOS2", "gene_names_refseq": "NOS2A; NOS2; iNOS", "protein_names_uniprotkb": "Nitric oxide synthase; 1.14.13.39", "protein_names_refseq": "nitric oxide synthase, inducible isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1222556); (R-BTA-392154); (R-BTA-9033241)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0034617 tetrahydrobiopterin binding;GO:0005516 calmodulin binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005777 peroxisome;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0030863 cortical cytoskeleton;GO:0005634 nucleus", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0032496 response to lipopolysaccharide;GO:0032755 positive regulation of interleukin-6 production;GO:0050796 regulation of insulin secretion;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MYR5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E6K1-1", "uniprot_id": [ { "id": "G5E6K1_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E6K1", "type": "external" } ], "mass": 28065.0, "length": 247, "protein_name": "Nicotinamide-nucleotide adenylyltransferase", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Nicotinamide-nucleotide adenylyltransferase; 2.7.7.18; 2.7.7.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-196807)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.1", "type": "external" }, { "id": "2.7.7.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004515 nicotinate-nucleotide adenylyltransferase activity;GO:0000309 nicotinamide-nucleotide adenylyltransferase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005739 mitochondrion", "go_biological_process": "GO:0034355 NAD+ biosynthetic process via the salvage pathway;GO:0009435 NAD+ biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E6K1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIC5-1", "uniprot_id": [ { "id": "ITPA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIC5", "type": "external" } ], "mass": 23061.0, "length": 208, "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "ITPA", "organism": "Bovine", "refseq_name": "inosine triphosphate pyrophosphatase", "refseq_ac": [ { "id": "NP_001069750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069750", "type": "external" } ], "gene_names_uniprotkb": "ITPA", "gene_names_refseq": "ITPA", "protein_names_uniprotkb": "Inosine triphosphate pyrophosphatase; 3.6.1.66; ITPase; Inosine triphosphatase; NTPase; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; XTP/dITP diphosphatase", "protein_names_refseq": "ITPase; NTPase; XTP/dITP diphosphatase; inosine triphosphatase A; inosine triphosphate pyrophosphatase; non-canonical purine NTP pyrophosphatase; non-standard purine NTP pyrophosphatase; nucleoside triphosphate pyrophosphatase; nucleoside-triphosphate diphosphatase", "tax_id": 9913, "disease": "", "pathway": " (bta:613653); (R-BTA-74259); (R-BTA-9755088)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions., [UniProtKB, UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.66", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0047429 nucleoside triphosphate diphosphatase activity;GO:0035870 dITP diphosphatase activity;GO:0036220 ITP diphosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009117 nucleotide metabolic process;GO:0009143 nucleoside triphosphate catabolic process;GO:0009204 deoxyribonucleoside triphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIC5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCA8-1", "uniprot_id": [ { "id": "3HAO_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCA8", "type": "external" } ], "mass": 32493.0, "length": 286, "protein_name": "3-hydroxyanthranilate 3,4-dioxygenase", "gene_name": "HAAO", "organism": "Bovine", "refseq_name": "3-hydroxyanthranilate 3,4-dioxygenase", "refseq_ac": [ { "id": "NP_001068926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068926", "type": "external" } ], "gene_names_uniprotkb": "HAAO", "gene_names_refseq": "HAAO", "protein_names_uniprotkb": "3-hydroxyanthranilate 3,4-dioxygenase; 1.13.11.6; 3-HAO; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; HAD", "protein_names_refseq": "3-HAO; 3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; HAD", "tax_id": 9913, "disease": "", "pathway": " (bta:510602); (R-BTA-71240)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19226621", "class_list": "", "function": "Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data show that 3-hydroxyanthranilate 3,4-dioxygenase is a monomer, characterized by the so-called cupin fold., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.6", "type": "external" } ], "go_molecular_function": "GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity;GO:0008198 ferrous iron binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006569 L-tryptophan catabolic process;GO:0009435 NAD+ biosynthetic process;GO:0019805 quinolinate biosynthetic process;GO:0043420 anthranilate metabolic process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VCA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82922-1", "uniprot_id": [ { "id": "RT29_BOVIN", "url": "https://www.uniprot.org/uniprot/P82922", "type": "external" } ], "mass": 45566.0, "length": 397, "protein_name": "Small ribosomal subunit protein mS29", "gene_name": "DAP3", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein mS29 isoform X2", "refseq_ac": [ { "id": "XP_005203705", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203705", "type": "external" } ], "gene_names_uniprotkb": "DAP3; MRPS29", "gene_names_refseq": "DAP3; MRPS29", "protein_names_uniprotkb": "Small ribosomal subunit protein mS29; 28S ribosomal protein S29, mitochondrial; 3.6.5.-; DAP-3; Death-associated protein 3; MRP-S29; S29mt", "protein_names_refseq": "small ribosomal subunit protein mS29 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "11279123", "class_list": "", "function": "As a component of the mitochondrial small ribosomal subunit, it plays a role in the translation of mitochondrial mRNAs. Involved in mediating interferon-gamma-induced cell death. Displays GTPase activity in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome;GO:0015935 small ribosomal subunit", "go_biological_process": "GO:0006915 apoptotic process;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P82922-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q148M6-1", "uniprot_id": [ { "id": "MXRA8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q148M6", "type": "external" } ], "mass": 52034.0, "length": 463, "protein_name": "Matrix remodeling-associated protein 8", "gene_name": "MXRA8", "organism": "Bovine", "refseq_name": "matrix remodeling-associated protein 8 precursor", "refseq_ac": [ { "id": "NP_001069298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069298", "type": "external" } ], "gene_names_uniprotkb": "MXRA8", "gene_names_refseq": "MXRA8", "protein_names_uniprotkb": "Matrix remodeling-associated protein 8; Limitrin", "protein_names_refseq": "limitrin; matrix remodeling-associated protein 8 precursor; matrix-remodeling-associated protein 8; matrix-remodelling associated 8", "tax_id": 9913, "disease": "", "pathway": " (bta:522392); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro. Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38. Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes. Stimulates formation of primary cilia in chondrocytes. Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway. Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis. Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells. Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK. May play a role in the maturation and maintenance of the blood-brain barrier., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0060857 establishment of glial blood-brain barrier", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q148M6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P585-1", "uniprot_id": [ { "id": "SMYD2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P585", "type": "external" } ], "mass": 49860.0, "length": 433, "protein_name": "N-lysine methyltransferase SMYD2", "gene_name": "SMYD2", "organism": "Bovine", "refseq_name": "N-lysine methyltransferase SMYD2", "refseq_ac": [ { "id": "NP_001069832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069832", "type": "external" } ], "gene_names_uniprotkb": "SMYD2", "gene_names_refseq": "SMYD2", "protein_names_uniprotkb": "N-lysine methyltransferase SMYD2; 2.1.1.-; 2.1.1.354; Histone methyltransferase SMYD2; SET and MYND domain-containing protein 2", "protein_names_refseq": "N-lysine methyltransferase SMYD2; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2", "tax_id": 9913, "disease": "", "pathway": " (bta:615229); (R-BTA-3214841); (R-BTA-6804760)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "3.4.24.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.71", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding;GO:0046975 histone H3K36 methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity;GO:0140999 histone H3K4 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P585-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5D0-1", "uniprot_id": [ { "id": "PPIH_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5D0", "type": "external" } ], "mass": 19208.0, "length": 177, "protein_name": "Peptidyl-prolyl cis-trans isomerase H", "gene_name": "PPIH", "organism": "Bovine", "refseq_name": "peptidyl-prolyl cis-trans isomerase H", "refseq_ac": [ { "id": "NP_001069086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069086", "type": "external" } ], "gene_names_uniprotkb": "PPIH", "gene_names_refseq": "PPIH", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase H; 5.2.1.8; PPIase H; Rotamase H", "protein_names_refseq": "PPIase H; peptidyl-prolyl cis-trans isomerase H; peptidylprolyl isomerase H (cyclophilin H); rotamase H", "tax_id": 9913, "disease": "", "pathway": " (bta:513428); (R-BTA-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5D0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5K3-1", "uniprot_id": [ { "id": "UBE2N_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5K3", "type": "external" } ], "mass": 17138.0, "length": 152, "protein_name": "Ubiquitin-conjugating enzyme E2 N", "gene_name": "UBE2N", "organism": "Bovine", "refseq_name": "ubiquitin-conjugating enzyme E2 N", "refseq_ac": [ { "id": "NP_001069726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069726", "type": "external" } ], "gene_names_uniprotkb": "UBE2N", "gene_names_refseq": "UBE2N", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 N; 2.3.2.23; E2 ubiquitin-conjugating enzyme N; Ubiquitin carrier protein N; Ubiquitin-protein ligase N", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme N; ubiquitin carrier protein N; ubiquitin conjugating enzyme E2N; ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); ubiquitin-protein ligase N", "tax_id": 9913, "disease": "", "pathway": " (bta:541130); (R-BTA-1169408); (R-BTA-168638); (R-BTA-202424); (R-BTA-2871837); (R-BTA-445989); (R-BTA-450302); (R-BTA-450321); (R-BTA-5205685); (R-BTA-5607764); (R-BTA-5693565); (R-BTA-5693571); (R-BTA-5693607); (R-BTA-5696395); (R-BTA-69473); (R-BTA-8866654); (R-BTA-9020702); (R-BTA-937039); (R-BTA-937041); (R-BTA-9646399); (R-BTA-975144); (R-BTA-983168)", "pathway_count": 22, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000151 ubiquitin ligase complex;GO:0031372 UBC13-MMS2 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0070534 protein K63-linked ubiquitination;GO:0006301 DNA damage tolerance;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5K3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RT6-1", "uniprot_id": [ { "id": "KI20A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RT6", "type": "external" } ], "mass": 100044.0, "length": 888, "protein_name": "Kinesin-like protein KIF20A", "gene_name": "KIF20A", "organism": "Bovine", "refseq_name": "kinesin-like protein KIF20A", "refseq_ac": [ { "id": "NP_001039753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039753", "type": "external" } ], "gene_names_uniprotkb": "KIF20A", "gene_names_refseq": "KIF20A", "protein_names_uniprotkb": "Kinesin-like protein KIF20A", "protein_names_refseq": "kinesin-like protein KIF20A", "tax_id": 9913, "disease": "", "pathway": " (bta:527854); (R-BTA-2132295); (R-BTA-68884); (R-BTA-983189)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0015031 protein transport;GO:0000281 mitotic cytokinesis;GO:0007018 microtubule-based movement;GO:0032465 regulation of cytokinesis;GO:0001578 microtubule bundle formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RT6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V7M7-1", "uniprot_id": [ { "id": "SKA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V7M7", "type": "external" } ], "mass": 29428.0, "length": 254, "protein_name": "SKA complex subunit 1", "gene_name": "SKA1", "organism": "Bovine", "refseq_name": "SKA complex subunit 1", "refseq_ac": [ { "id": "NP_001068795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068795", "type": "external" } ], "gene_names_uniprotkb": "SKA1", "gene_names_refseq": "SKA1", "protein_names_uniprotkb": "SKA complex subunit 1; Spindle and kinetochore-associated protein 1", "protein_names_refseq": "SKA complex subunit 1; spindle and KT associated 1; spindle and kinetochore-associated protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:507703); (R-BTA-141430); (R-BTA-141444); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-5663220); (R-BTA-9648025)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces. The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules. The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase. In the complex, it mediates interactions with microtubules. It also stimulates AURKB/Aurora B catalytic activity (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X7D1", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005876 spindle microtubule;GO:0072687 meiotic spindle;GO:1990498 mitotic spindle microtubule;GO:0072686 mitotic spindle", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V7M7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA45-1", "uniprot_id": [ { "id": "AGFG1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TA45", "type": "external" } ], "mass": 58134.0, "length": 562, "protein_name": "Arf-GAP domain and FG repeat-containing protein 1", "gene_name": "AGFG1", "organism": "Bovine", "refseq_name": "arf-GAP domain and FG repeat-containing protein 1", "refseq_ac": [ { "id": "NP_001033260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033260", "type": "external" } ], "gene_names_uniprotkb": "AGFG1; HRB; RIP", "gene_names_refseq": "AGFG1; HRB", "protein_names_uniprotkb": "Arf-GAP domain and FG repeat-containing protein 1; HIV-1 Rev-binding protein homolog; Nucleoporin-like protein RIP", "protein_names_refseq": "HIV-1 Rev binding protein; HIV-1 Rev-binding protein homolog; arf-GAP domain and FG repeat-containing protein 1; arf-GAP domain and FG repeats-containing protein 1; nucleoporin-like protein RIP", "tax_id": 9913, "disease": "", "pathway": " (bta:536149)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0043025 neuronal cell body;GO:0042995 cell projection", "go_biological_process": "GO:0001675 acrosome assembly;GO:0007289 spermatid nucleus differentiation;GO:0045109 intermediate filament organization;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TA45-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JQC5-1", "uniprot_id": [ { "id": "RMD3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JQC5", "type": "external" } ], "mass": 51906.0, "length": 471, "protein_name": "Regulator of microtubule dynamics protein 3", "gene_name": "RMDN3", "organism": "Bovine", "refseq_name": "regulator of microtubule dynamics protein 3", "refseq_ac": [ { "id": "NP_001069147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069147", "type": "external" } ], "gene_names_uniprotkb": "RMDN3; FAM82A2; FAM82C", "gene_names_refseq": "FAM82A2; FAM82C; RMDN3", "protein_names_uniprotkb": "Regulator of microtubule dynamics protein 3; Protein FAM82A2; Protein FAM82C; RMD-3", "protein_names_refseq": "RMD-3; family with sequence similarity 82, member A2; family with sequence similarity 82, member C; regulator of microtubule dynamics protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:514748)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity)., [UniProtKB]; Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005876 spindle microtubule", "go_biological_process": "GO:0030154 cell differentiation;GO:0006874 intracellular calcium ion homeostasis;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1JQC5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KHT8-1", "uniprot_id": [ { "id": "DIM1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KHT8", "type": "external" } ], "mass": 35167.0, "length": 313, "protein_name": "Dimethyladenosine transferase", "gene_name": "DIMT1", "organism": "Bovine", "refseq_name": "dimethyladenosine transferase", "refseq_ac": [ { "id": "NP_001039501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039501", "type": "external" } ], "gene_names_uniprotkb": "DIMT1; DIMT1L", "gene_names_refseq": "DIMT1L; DIMT1; HSA9761", "protein_names_uniprotkb": "Dimethyladenosine transferase; 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; 18S rRNA dimethylase; 2.1.1.183; DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1-like; S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase", "protein_names_refseq": "18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))- dimethyltransferase; 18S rRNA dimethylase; DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1-like; DIMT1 rRNA methyltransferase and ribosome maturation factor; S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase; dimethyladenosine transferase; probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))- dimethyltransferase; probable 18S rRNA dimethylase; probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase; probable dimethyladenosine transferase", "tax_id": 9913, "disease": "", "pathway": " (bta:509725)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.183", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.183", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0052909 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity;GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0031167 rRNA methylation;GO:2000234 positive regulation of rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KHT8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RY8-1", "uniprot_id": [ { "id": "AP4M1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RY8", "type": "external" } ], "mass": 49854.0, "length": 452, "protein_name": "AP-4 complex subunit mu-1", "gene_name": "AP4M1", "organism": "Bovine", "refseq_name": "AP-4 complex subunit mu-1", "refseq_ac": [ { "id": "NP_001070567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070567", "type": "external" } ], "gene_names_uniprotkb": "AP4M1", "gene_names_refseq": "AP4M1", "protein_names_uniprotkb": "AP-4 complex subunit mu-1; AP-4 adaptor complex mu subunit; Adaptor-related protein complex 4 subunit mu-1; Mu subunit of AP-4; Mu-adaptin-related protein 2; Mu4-adaptin; mu-ARP2; mu4", "protein_names_refseq": "AP-4 adapter complex mu subunit; AP-4 adaptor complex mu subunit; AP-4 complex subunit mu-1; adapter-related protein complex 4 mu-1 subunit; adapter-related protein complex 4 subunit mu-1; adaptor related protein complex 4 mu 1 subunit; mu subunit of AP-4; mu-ARP2; mu-adaptin-related protein 2; mu4-adaptin; mu4", "tax_id": 9913, "disease": "", "pathway": " (bta:768040); (R-BTA-432720)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0030121 AP-1 adaptor complex;GO:0030124 AP-4 adaptor complex", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0006605 protein targeting;GO:0008104 intracellular protein localization;GO:0090160 Golgi to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RY8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9V9-1", "uniprot_id": [ { "id": "PHF10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9V9", "type": "external" } ], "mass": 46437.0, "length": 410, "protein_name": "PHD finger protein 10", "gene_name": "PHF10", "organism": "Bovine", "refseq_name": "PHD finger protein 10", "refseq_ac": [ { "id": "NP_001033141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033141", "type": "external" } ], "gene_names_uniprotkb": "PHF10; BAF45A", "gene_names_refseq": "PHF10", "protein_names_uniprotkb": "PHD finger protein 10; BAF45a; BRG1-associated factor 45a", "protein_names_refseq": "BAF45a; BRG1-associated factor 45a; PHD finger protein 10", "tax_id": 9913, "disease": "", "pathway": " (bta:507648); (R-BTA-9933939); (R-BTA-9933946); (R-BTA-9934037)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0004402 histone acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0071564 npBAF complex;GO:0000785 chromatin;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2T9V9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02366-1", "uniprot_id": [ { "id": "NDUA6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02366", "type": "external" } ], "mass": 15053.0, "length": 128, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6", "gene_name": "NDUFA6", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6", "refseq_ac": [ { "id": "NP_786985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786985", "type": "external" } ], "gene_names_uniprotkb": "NDUFA6", "gene_names_refseq": "B14; NDUFA6", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; CI-B14; Complex I-B14; NADH-ubiquinone oxidoreductase B14 subunit", "protein_names_refseq": "CI-B14; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; NADH-ubiquinone oxidoreductase B14 subunit; complex I-B14", "tax_id": 9913, "disease": "", "pathway": " (bta:327670); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10852722;1518044;18721790", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0E4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02366-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMR2-1", "uniprot_id": [ { "id": "RU17_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMR2", "type": "external" } ], "mass": 51426.0, "length": 439, "protein_name": "U1 small nuclear ribonucleoprotein 70 kDa", "gene_name": "SNRNP70", "organism": "Bovine", "refseq_name": "U1 small nuclear ribonucleoprotein 70 kDa", "refseq_ac": [ { "id": "NP_001069514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069514", "type": "external" } ], "gene_names_uniprotkb": "SNRNP70; SNRP70", "gene_names_refseq": "SNRNP70; SNRP70", "protein_names_uniprotkb": "U1 small nuclear ribonucleoprotein 70 kDa; U1 snRNP 70 kDa; U1-70K; snRNP70", "protein_names_refseq": "U1 small nuclear ribonucleoprotein 70 kDa; U1 snRNP 70 kDa; U1-70K; small nuclear ribonucleoprotein 70kDa (U1); small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)", "tax_id": 9913, "disease": "", "pathway": " (bta:535113)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0030619 U1 snRNA binding;GO:0017069 snRNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0043202 lysosomal lumen", "go_biological_process": "GO:1904715 negative regulation of chaperone-mediated autophagy;GO:0043484 regulation of RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0061084 negative regulation of protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMR2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KI22-1", "uniprot_id": [ { "id": "CCND1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KI22", "type": "external" } ], "mass": 33407.0, "length": 295, "protein_name": "G1/S-specific cyclin-D1", "gene_name": "CCND1", "organism": "Bovine", "refseq_name": "G1/S-specific cyclin-D1", "refseq_ac": [ { "id": "NP_001039738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039738", "type": "external" } ], "gene_names_uniprotkb": "CCND1", "gene_names_refseq": "CCND1", "protein_names_uniprotkb": "G1/S-specific cyclin-D1", "protein_names_refseq": "G1/S-specific cyclin-D1", "tax_id": 9913, "disease": "", "pathway": " (bta:524530); (R-BTA-187577); (R-BTA-3214858); (R-BTA-69231); (R-BTA-75815); (R-BTA-8849470); (R-BTA-8878166); (R-BTA-8934593); (R-BTA-8951936); (R-BTA-9754119); (R-BTA-9929491)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "14967908;17454165;27816766", "class_list": "", "function": "17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 kinase) pathway., [RefSeq, PubMed]; CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells., [RefSeq, PubMed]; Cyclin D1, CDK2 and CDK4 are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation, [RefSeq, PubMed]; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0043539 protein serine/threonine kinase activator activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:0004672 protein kinase activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0017053 transcription repressor complex;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2KI22-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27991-1", "uniprot_id": [ { "id": "MYH10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27991", "type": "external" } ], "mass": 229099.0, "length": 1976, "protein_name": "Myosin-10", "gene_name": "MYH10", "organism": "Bovine", "refseq_name": "myosin-10", "refseq_ac": [ { "id": "NP_777259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777259", "type": "external" } ], "gene_names_uniprotkb": "MYH10", "gene_names_refseq": "MYH10", "protein_names_uniprotkb": "Myosin-10; Cellular myosin heavy chain, type B; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; NMMHC II-b; NMMHC-B; NMMHC-IIB; Non-muscle myosin heavy chain B; Non-muscle myosin heavy chain IIb", "protein_names_refseq": "NMMHC II-b; NMMHC-B; NMMHC-IIB; cellular myosin heavy chain, type B; myosin heavy chain, non-muscle IIb; myosin, heavy polypeptide 10, non-muscle; myosin-10; non-muscle myosin heavy chain B; non-muscle myosin heavy chain IIb; nonmuscle myosin heavy chain B", "tax_id": 9913, "disease": "", "pathway": " (bta:317655); (R-BTA-5627123)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7782316", "class_list": "", "function": "Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0043531 ADP binding", "go_cellular_component": "GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0030027 lamellipodium;GO:0032982 myosin filament;GO:0016460 myosin II complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0031032 actomyosin structure organization;GO:0008360 regulation of cell shape;GO:0000281 mitotic cytokinesis;GO:0050714 positive regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q27991-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DH8-1", "uniprot_id": [ { "id": "XRCC3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DH8", "type": "external" } ], "mass": 36755.0, "length": 341, "protein_name": "DNA repair protein XRCC3", "gene_name": "XRCC3", "organism": "Bovine", "refseq_name": "DNA repair protein XRCC3", "refseq_ac": [ { "id": "NP_001071585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071585", "type": "external" } ], "gene_names_uniprotkb": "XRCC3", "gene_names_refseq": "XRCC3", "protein_names_uniprotkb": "DNA repair protein XRCC3; X-ray repair cross-complementing protein 3", "protein_names_refseq": "DNA repair protein XRCC3; X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair cross-complementing protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:768244); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5693568); (R-BTA-5693579)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0033065 Rad51C-XRCC3 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0000724 double-strand break repair via homologous recombination;GO:0090656 t-circle formation;GO:0000722 telomere maintenance via recombination;GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DH8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9R2-1", "uniprot_id": [ { "id": "KASH5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9R2", "type": "external" } ], "mass": 58598.0, "length": 525, "protein_name": "Protein KASH5", "gene_name": "KASH5", "organism": "Bovine", "refseq_name": "protein KASH5", "refseq_ac": [ { "id": "NP_001070414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070414", "type": "external" } ], "gene_names_uniprotkb": "KASH5; CCDC155", "gene_names_refseq": "CCDC155; KASH5", "protein_names_uniprotkb": "Protein KASH5; Coiled-coil domain-containing protein 155", "protein_names_refseq": "coiled-coil domain containing 155; coiled-coil domain-containing protein 155; protein KASH5", "tax_id": 9913, "disease": "", "pathway": " (bta:617651)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1N496", "ec_number_list": [], "go_molecular_function": "GO:0070840 dynein complex binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0090619 meiotic spindle pole;GO:0005640 nuclear outer membrane;GO:0000800 lateral element;GO:0000781 chromosome, telomeric region;GO:0034993 meiotic nuclear membrane microtubule tethering complex", "go_biological_process": "GO:0090220 chromosome localization to nuclear envelope involved in homologous chromosome segregation;GO:0007015 actin filament organization;GO:0051653 spindle localization;GO:0007129 homologous chromosome pairing at meiosis;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2T9R2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VD22-1", "uniprot_id": [ { "id": "STK33_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VD22", "type": "external" } ], "mass": 54627.0, "length": 486, "protein_name": "Serine/threonine-protein kinase 33", "gene_name": "STK33", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase 33", "refseq_ac": [ { "id": "NP_001069376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069376", "type": "external" } ], "gene_names_uniprotkb": "STK33", "gene_names_refseq": "STK33", "protein_names_uniprotkb": "Serine/threonine-protein kinase 33; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase 33", "tax_id": 9913, "disease": "", "pathway": " (bta:528309)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine protein kinase which phosphorylates vimentin/VIM. Therefore may play a specific role in the dynamic behavior of the intermediate filament cytoskeleton (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0002177 manchette", "go_biological_process": "GO:0044773 mitotic DNA damage checkpoint signaling;GO:0007283 spermatogenesis;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1905198 manchette assembly;GO:1902915 negative regulation of protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VD22-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ44-1", "uniprot_id": [ { "id": "PTPA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ44", "type": "external" } ], "mass": 36882.0, "length": 324, "protein_name": "Serine/threonine-protein phosphatase 2A activator", "gene_name": "PTPA", "organism": "Bovine", "refseq_name": "serine/threonine-protein phosphatase 2A activator", "refseq_ac": [ { "id": "NP_001039638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039638", "type": "external" } ], "gene_names_uniprotkb": "PTPA; PPP2R4", "gene_names_refseq": "PPP2R4; PTPA", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A activator; 5.2.1.8; PP2A, subunit B', PR53 isoform; PTPA; Phosphotyrosyl phosphatase activator; Serine/threonine-protein phosphatase 2A regulatory subunit 4; Serine/threonine-protein phosphatase 2A regulatory subunit B'", "protein_names_refseq": "phosphotyrosyl phosphatase activator; protein phosphatase 2A activator, regulatory subunit 4; protein phosphatase 2A, regulatory subunit B' (PR 53); serine/threonine-protein phosphatase 2A activator; serine/threonine-protein phosphatase 2A regulatory subunit 4; serine/threonine-protein phosphatase 2A regulatory subunit B'", "tax_id": 9913, "disease": "", "pathway": " (bta:514460)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008160 protein tyrosine phosphatase activator activity;GO:0003755 peptidyl-prolyl cis-trans isomerase activity;GO:0019211 phosphatase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000159 protein phosphatase type 2A complex;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007052 mitotic spindle organization;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJ44-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8S0-1", "uniprot_id": [ { "id": "HGS_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8S0", "type": "external" } ], "mass": 85786.0, "length": 777, "protein_name": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "gene_name": "HGS", "organism": "Bovine", "refseq_name": "hepatocyte growth factor-regulated tyrosine kinase substrate", "refseq_ac": [ { "id": "NP_001039554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039554", "type": "external" } ], "gene_names_uniprotkb": "HGS", "gene_names_refseq": "HGS; HRS", "protein_names_uniprotkb": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "protein_names_refseq": "hepatocyte growth factor-regulated tyrosine kinase substrate", "tax_id": 9913, "disease": "", "pathway": " (bta:511582); (R-BTA-182971); (R-BTA-432720); (R-BTA-5689880); (R-BTA-6807004); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-9013420); (R-BTA-917729); (R-BTA-9706019)", "pathway_count": 10, "publication_count": 2, "publication_id_list": "16305752;16462748", "class_list": "", "function": "Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Structure of a complex of Hrs-UIM and ubiquitin at 1.7-A resolution [ubiquitin], [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q2NKZ6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding;GO:0019904 protein domain specific binding;GO:0044389 ubiquitin-like protein ligase binding", "go_cellular_component": "GO:0005769 early endosome;GO:0031901 early endosome membrane;GO:0032585 multivesicular body membrane;GO:0033565 ESCRT-0 complex;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0031623 receptor internalization;GO:0032456 endocytic recycling;GO:0010324 membrane invagination;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0V8S0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ61-1", "uniprot_id": [ { "id": "ELP3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ61", "type": "external" } ], "mass": 62331.0, "length": 547, "protein_name": "Elongator complex protein 3", "gene_name": "ELP3", "organism": "Bovine", "refseq_name": "elongator complex protein 3", "refseq_ac": [ { "id": "NP_001124234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124234", "type": "external" } ], "gene_names_uniprotkb": "ELP3", "gene_names_refseq": "ELP3", "protein_names_uniprotkb": "Elongator complex protein 3; 2.3.1.311; tRNA uridine(34) acetyltransferase", "protein_names_refseq": "elongation protein 3 homolog; elongator complex protein 3; protein lysine acetyltransferase ELP3; tRNA uridine(34) acetyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:784720)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Not a major acetyltransferase of tubulin. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Required for acetylation of GJA1 in the developing cerebral cortex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.311", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.311", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0000049 tRNA binding;GO:0106261 tRNA uridine(34) acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0033588 elongator holoenzyme complex;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030335 positive regulation of cell migration;GO:0001764 neuron migration;GO:0007417 central nervous system development;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJ61-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5F3-1", "uniprot_id": [ { "id": "LIN7C_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5F3", "type": "external" } ], "mass": 21834.0, "length": 197, "protein_name": "Protein lin-7 homolog C", "gene_name": "LIN7C", "organism": "Bovine", "refseq_name": "protein lin-7 homolog C", "refseq_ac": [ { "id": "NP_001068899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068899", "type": "external" } ], "gene_names_uniprotkb": "LIN7C", "gene_names_refseq": "LIN7C", "protein_names_uniprotkb": "Protein lin-7 homolog C; Lin-7C", "protein_names_refseq": "lin-7C; protein lin-7 homolog C", "tax_id": 9913, "disease": "", "pathway": " (bta:510125); (R-BTA-212676)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0008092 cytoskeletal protein binding;GO:0097016 L27 domain binding", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0015031 protein transport;GO:0007269 neurotransmitter secretion;GO:0006887 exocytosis;GO:0048489 synaptic vesicle transport;GO:0008582 regulation of synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5F3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RT9-1", "uniprot_id": [ { "id": "CXL16_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RT9", "type": "external" } ], "mass": 27586.0, "length": 252, "protein_name": "C-X-C motif chemokine 16", "gene_name": "CXCL16", "organism": "Bovine", "refseq_name": "C-X-C motif chemokine 16 precursor", "refseq_ac": [ { "id": "NP_001039560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039560", "type": "external" } ], "gene_names_uniprotkb": "CXCL16", "gene_names_refseq": "CXCL16", "protein_names_uniprotkb": "C-X-C motif chemokine 16; Transmembrane chemokine CXCL16", "protein_names_refseq": "C-X-C motif chemokine 16 precursor; C-X-C motif chemokine 16; transmembrane chemokine CXCL16", "tax_id": 9913, "disease": "", "pathway": " (bta:511671); (R-BTA-380108); (R-BTA-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005041 low-density lipoprotein particle receptor activity;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration;GO:0034612 response to tumor necrosis factor;GO:0006898 receptor-mediated endocytosis;GO:0010818 T cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RT9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QG5-1", "uniprot_id": [ { "id": "UB2G2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QG5", "type": "external" } ], "mass": 18552.0, "length": 165, "protein_name": "Ubiquitin-conjugating enzyme E2 G2", "gene_name": "UBE2G2", "organism": "Bovine", "refseq_name": "ubiquitin-conjugating enzyme E2 G2", "refseq_ac": [ { "id": "NP_001069796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069796", "type": "external" } ], "gene_names_uniprotkb": "UBE2G2; UBC7", "gene_names_refseq": "UBE2G2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 G2; 2.3.2.23; E2 ubiquitin-conjugating enzyme G2; Ubiquitin carrier protein G2; Ubiquitin-protein ligase G2", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme G2; ubiquitin carrier protein G2; ubiquitin-conjugating enzyme E2 G2; ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast); ubiquitin-protein ligase G2", "tax_id": 9913, "disease": "", "pathway": " (bta:614471); (R-BTA-8866652); (R-BTA-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0070936 protein K48-linked ubiquitination;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q17QG5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9V8-1", "uniprot_id": [ { "id": "DTD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9V8", "type": "external" } ], "mass": 23232.0, "length": 209, "protein_name": "D-aminoacyl-tRNA deacylase 1", "gene_name": "DTD1", "organism": "Bovine", "refseq_name": "D-aminoacyl-tRNA deacylase 1", "refseq_ac": [ { "id": "NP_001033193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033193", "type": "external" } ], "gene_names_uniprotkb": "DTD1; HARS2", "gene_names_refseq": "DTD1; DTD; DUE-B", "protein_names_uniprotkb": "D-aminoacyl-tRNA deacylase 1; 3.1.1.96; DNA-unwinding element-binding protein B; DTD; DUE-B; Gly-tRNA(Ala) deacylase", "protein_names_refseq": "D-aminoacyl-tRNA deacylase 1; D-tyrosyl-tRNA deacylase 1 homolog; D-tyrosyl-tRNA(Tyr) deacylase 1; DNA-unwinding element-binding protein B; gly-tRNA(Ala) deacylase; histidyl tRNA synthetase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:514493)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes., [UniProtKB, UniProtKB]; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.96", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.96", "type": "external" } ], "go_molecular_function": "GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity;GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0000049 tRNA binding;GO:0106026 Gly-tRNA(Ala) deacylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006399 tRNA metabolic process;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2T9V8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08D91-1", "uniprot_id": [ { "id": "K2C75_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08D91", "type": "external" } ], "mass": 59036.0, "length": 543, "protein_name": "Keratin, type II cytoskeletal 75", "gene_name": "KRT5; KRT6A; KRT75", "organism": "Bovine", "refseq_name": "keratin, type II cytoskeletal 75", "refseq_ac": [ { "id": "NP_001070385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070385", "type": "external" } ], "gene_names_uniprotkb": "KRT5; KRT6A; KRT75; KRT6A", "gene_names_refseq": "KRT75", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 75; CK-75; Cytokeratin-75; K75; Keratin-6 hair follicle; Keratin-75; Type II keratin-K6hf; Type-II keratin Kb18", "protein_names_refseq": "CK-75; K75; cytokeratin-75; keratin, type II cytoskeletal 75; keratin-6 hair follicle; type II keratin-K6hf; type-II keratin Kb18", "tax_id": 9913, "disease": "", "pathway": " (bta:539683); (R-BTA-6805567); (R-BTA-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "41018975", "class_list": "", "function": "Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity)., [UniProtKB]; Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress. Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q08D91-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V7N0-1", "uniprot_id": [ { "id": "VAMP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V7N0", "type": "external" } ], "mass": 12860.0, "length": 118, "protein_name": "Vesicle-associated membrane protein 1", "gene_name": "VAMP1", "organism": "Bovine", "refseq_name": "vesicle-associated membrane protein 1", "refseq_ac": [ { "id": "NP_001069098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069098", "type": "external" } ], "gene_names_uniprotkb": "VAMP1; SYB1", "gene_names_refseq": "VAMP1", "protein_names_uniprotkb": "Vesicle-associated membrane protein 1; Synaptobrevin-1; VAMP-1", "protein_names_refseq": "VAMP-1; synaptobrevin-1; vesicle-associated membrane protein 1 (synaptobrevin 1); vesicle-associated membrane protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:513621)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Involved in the targeting and/or fusion of transport vesicles to their target membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IFF1", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0031201 SNARE complex;GO:0016020 membrane", "go_biological_process": "GO:0035493 SNARE complex assembly;GO:0006906 vesicle fusion;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V7N0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RJ9-1", "uniprot_id": [ { "id": "PSRC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RJ9", "type": "external" } ], "mass": 34326.0, "length": 326, "protein_name": "Proline/serine-rich coiled-coil protein 1", "gene_name": "PSRC1", "organism": "Bovine", "refseq_name": "proline/serine-rich coiled-coil protein 1", "refseq_ac": [ { "id": "NP_001039966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039966", "type": "external" } ], "gene_names_uniprotkb": "PSRC1", "gene_names_refseq": "PSRC1", "protein_names_uniprotkb": "Proline/serine-rich coiled-coil protein 1", "protein_names_refseq": "p53-regulated DDA3; proline/serine-rich coiled-coil 1; proline/serine-rich coiled-coil protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:541250)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0005856 cytoskeleton;GO:0030496 midbody", "go_biological_process": "GO:0051301 cell division;GO:0007080 mitotic metaphase chromosome alignment;GO:0060236 regulation of mitotic spindle organization;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RJ9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28034-1", "uniprot_id": [ { "id": "GLU2B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28034", "type": "external" } ], "mass": 60151.0, "length": 533, "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "organism": "Bovine", "refseq_name": "glucosidase 2 subunit beta precursor", "refseq_ac": [ { "id": "NP_788835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788835", "type": "external" } ], "gene_names_uniprotkb": "PRKCSH", "gene_names_refseq": "PRKCSH; VASAP-60", "protein_names_uniprotkb": "Glucosidase 2 subunit beta; 80K-H protein; Glucosidase II subunit beta; PKCSH; Protein kinase C substrate 60.1 kDa protein heavy chain; VASAP-60; Vacuolar system-associated protein 60", "protein_names_refseq": "80K-H protein; PKCSH; glucosidase 2 subunit beta precursor; glucosidase 2 subunit beta; glucosidase II subunit beta; protein kinase C substrate 60.1 kDa protein heavy chain; vacuolar system associated protein-60", "tax_id": 9913, "disease": "", "pathway": " (bta:338067); (R-BTA-381426); (R-BTA-8957275); (R-BTA-9768727)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10684806;16305752;17250974", "class_list": "", "function": "Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (By similarity). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study is the first to report that VASAP-60 is up-regulated in granulosa cells of dominant follicles, to document the primary structure of the VASAP-60 gene and the YY1 binding to promoter may act as a positive transcriptional regulator., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A7E3R7;Q3SX37", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0005509 calcium ion binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0043231 intracellular membrane-bounded organelle;GO:0017177 glucosidase II complex", "go_biological_process": "GO:0001889 liver development;GO:0006491 N-glycan processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q28034-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2NL14-1", "uniprot_id": [ { "id": "KANL2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2NL14", "type": "external" } ], "mass": 51208.0, "length": 458, "protein_name": "KAT8 regulatory NSL complex subunit 2", "gene_name": "KANSL2", "organism": "Bovine", "refseq_name": "KAT8 regulatory NSL complex subunit 2", "refseq_ac": [ { "id": "NP_001019742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019742", "type": "external" } ], "gene_names_uniprotkb": "KANSL2; NSL2", "gene_names_refseq": "C12orf41; C5H12orf41; C5HANSL2; KANSL2", "protein_names_uniprotkb": "KAT8 regulatory NSL complex subunit 2; NSL complex protein NSL2; Non-specific lethal 2 homolog", "protein_names_refseq": "KAT8 regulatory NSL complex subunit 2; NSL complex protein NSL2; non-specific lethal 2 homolog; uncharacterized protein C12orf41 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:540194); (R-BTA-3214847); (R-BTA-9772755)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58D11", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0000123 histone acetyltransferase complex;GO:0044545 NSL complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2NL14-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ51-1", "uniprot_id": [ { "id": "RA51D_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ51", "type": "external" } ], "mass": 34651.0, "length": 326, "protein_name": "DNA repair protein RAD51 homolog 4", "gene_name": "RAD51D", "organism": "Bovine", "refseq_name": "DNA repair protein RAD51 homolog 4", "refseq_ac": [ { "id": "NP_001039769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039769", "type": "external" } ], "gene_names_uniprotkb": "RAD51D; RAD51L3", "gene_names_refseq": "RAD51D; RAD51L3", "protein_names_uniprotkb": "DNA repair protein RAD51 homolog 4; R51H3; RAD51 homolog D; RAD51-like protein 3", "protein_names_refseq": "DNA repair protein RAD51 homolog 4; R51H3; RAD51-like 3; RAD51-like protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:529507); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5693568); (R-BTA-5693579); (R-BTA-5693616)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003697 single-stranded DNA binding;GO:0008094 ATP-dependent activity, acting on DNA;GO:0043015 gamma-tubulin binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005815 microtubule organizing center;GO:0005657 replication fork;GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000723 telomere maintenance;GO:0000724 double-strand break repair via homologous recombination;GO:0007131 reciprocal meiotic recombination;GO:0042148 DNA strand invasion;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ51-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V898-1", "uniprot_id": [ { "id": "NELFE_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V898", "type": "external" } ], "mass": 42331.0, "length": 374, "protein_name": "Negative elongation factor E", "gene_name": "NELFE", "organism": "Bovine", "refseq_name": "negative elongation factor E", "refseq_ac": [ { "id": "NP_001069672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069672", "type": "external" } ], "gene_names_uniprotkb": "NELFE; RDBP", "gene_names_refseq": "NELFE; RDBP", "protein_names_uniprotkb": "Negative elongation factor E; NELF-E; RNA-binding protein RD", "protein_names_refseq": "NELF-E; RD RNA binding protein; RNA-binding protein RD; negative elongation factor E", "tax_id": 9913, "disease": "", "pathway": " (bta:540158); (R-BTA-112382); (R-BTA-113418); (R-BTA-674695); (R-BTA-6796648); (R-BTA-75955)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0140870 RNA polymerase inhibitor activity", "go_cellular_component": "GO:0005694 chromosome;GO:0032021 NELF complex;GO:0016604 nuclear body;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0034244 negative regulation of transcription elongation by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0160239 transcription pausing by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V898-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QN4-1", "uniprot_id": [ { "id": "SCN1B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QN4", "type": "external" } ], "mass": 24711.0, "length": 218, "protein_name": "Sodium channel regulatory subunit beta-1", "gene_name": "SCN1B", "organism": "Bovine", "refseq_name": "sodium channel regulatory subunit beta-1 precursor", "refseq_ac": [ { "id": "NP_001069964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069964", "type": "external" } ], "gene_names_uniprotkb": "SCN1B", "gene_names_refseq": "SCN1B", "protein_names_uniprotkb": "Sodium channel regulatory subunit beta-1", "protein_names_refseq": "sodium channel regulatory subunit beta-1 precursor; sodium channel regulatory subunit beta-1; sodium channel subunit beta-1; sodium channel, voltage-gated, type I, beta subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:618204); (R-BTA-5576892)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN4A/Nav1.4, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019871 sodium channel inhibitor activity;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043204 perikaryon;GO:0001518 voltage-gated sodium channel complex;GO:0014704 intercalated disc", "go_biological_process": "GO:0086091 regulation of heart rate by cardiac conduction;GO:0035725 sodium ion transmembrane transport;GO:0086012 membrane depolarization during cardiac muscle cell action potential;GO:1905152 positive regulation of voltage-gated sodium channel activity;GO:0086002 cardiac muscle cell action potential involved in contraction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q17QN4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DM7-1", "uniprot_id": [ { "id": "SEPT3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DM7", "type": "external" } ], "mass": 40538.0, "length": 357, "protein_name": "Neuronal-specific septin-3", "gene_name": "SEPTIN3", "organism": "Bovine", "refseq_name": "neuronal-specific septin-3", "refseq_ac": [ { "id": "NP_001070417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070417", "type": "external" } ], "gene_names_uniprotkb": "SEPTIN3; SEPT3", "gene_names_refseq": "SEPT3; SEPTIN3", "protein_names_uniprotkb": "Neuronal-specific septin-3", "protein_names_refseq": "neuronal-specific septin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:618235)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)., [UniProtKB]; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0015630 microtubule cytoskeleton;GO:0098793 presynapse;GO:0031105 septin complex;GO:0032153 cell division site", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DM7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q148H0-1", "uniprot_id": [ { "id": "MIC26_BOVIN", "url": "https://www.uniprot.org/uniprot/Q148H0", "type": "external" } ], "mass": 22562.0, "length": 198, "protein_name": "MICOS complex subunit MIC26", "gene_name": "APOO", "organism": "Bovine", "refseq_name": "MICOS complex subunit MIC26 precursor", "refseq_ac": [ { "id": "NP_001069107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069107", "type": "external" } ], "gene_names_uniprotkb": "APOO; FAM121B; MIC23; MIC26", "gene_names_refseq": "APOO", "protein_names_uniprotkb": "MICOS complex subunit MIC26; Apolipoprotein O; MICOS complex subunit MIC23; Protein FAM121B", "protein_names_refseq": "MICOS complex subunit MIC23; MICOS complex subunit MIC26 precursor; MICOS complex subunit MIC26", "tax_id": 9913, "disease": "", "pathway": " (bta:513847)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005743 mitochondrial inner membrane;GO:0034364 high-density lipoprotein particle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q148H0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ81-1", "uniprot_id": [ { "id": "TBB6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ81", "type": "external" } ], "mass": 49900.0, "length": 446, "protein_name": "Tubulin beta-6 chain", "gene_name": "TUBB6", "organism": "Bovine", "refseq_name": "tubulin beta-6 chain", "refseq_ac": [ { "id": "NP_001039838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039838", "type": "external" } ], "gene_names_uniprotkb": "TUBB6", "gene_names_refseq": "TUBB6", "protein_names_uniprotkb": "Tubulin beta-6 chain", "protein_names_refseq": "tubulin beta-6 chain", "tax_id": 9913, "disease": "", "pathway": " (bta:534206); (R-BTA-2132295); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-3371497); (R-BTA-5620924); (R-BTA-6807878); (R-BTA-6811436); (R-BTA-9646399); (R-BTA-9648025)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "2207090;6504138;7704569", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2HJ81-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28851-1", "uniprot_id": [ { "id": "ATPK_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28851", "type": "external" } ], "mass": 10297.0, "length": 88, "protein_name": "ATP synthase F(0) complex subunit f, mitochondrial", "gene_name": "ATP5MF", "organism": "Bovine", "refseq_name": "ATP synthase F(0) complex subunit f, mitochondrial", "refseq_ac": [ { "id": "NP_001107191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107191", "type": "external" } ], "gene_names_uniprotkb": "ATP5MF; ATP5J2", "gene_names_refseq": "ATP5J2; ATP5MF", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit f, mitochondrial; ATP synthase membrane subunit f", "protein_names_refseq": "ATP synthase F(0) complex subunit f, mitochondrial; ATP synthase subunit f, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F2; F1Fo-ATP synthase complex Fo membrane domain f subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:506492); (R-BTA-163210); (R-BTA-8949613)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17570365;25851905;28100784;8011660", "class_list": "", "function": "Subunit f, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32P94", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:1902600 proton transmembrane transport;GO:0006754 ATP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q28851-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ94-1", "uniprot_id": [ { "id": "DNJA2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ94", "type": "external" } ], "mass": 45762.0, "length": 412, "protein_name": "DnaJ homolog subfamily A member 2", "gene_name": "DNAJA2", "organism": "Bovine", "refseq_name": "dnaJ homolog subfamily A member 2", "refseq_ac": [ { "id": "NP_001035581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035581", "type": "external" } ], "gene_names_uniprotkb": "DNAJA2", "gene_names_refseq": "DNAJA2", "protein_names_uniprotkb": "DnaJ homolog subfamily A member 2", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily A, member 2; dnaJ homolog subfamily A member 2", "tax_id": 9913, "disease": "", "pathway": " (bta:360006); (R-BTA-3371497)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0034605 cellular response to heat;GO:0042026 protein refolding;GO:0006457 protein folding;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ94-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51122-1", "uniprot_id": [ { "id": "AN32A_BOVIN", "url": "https://www.uniprot.org/uniprot/P51122", "type": "external" } ], "mass": 28617.0, "length": 249, "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "gene_name": "ANP32A", "organism": "Bovine", "refseq_name": "acidic leucine-rich nuclear phosphoprotein 32 family member A", "refseq_ac": [ { "id": "NP_001181948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181948", "type": "external" } ], "gene_names_uniprotkb": "ANP32A; LANP; PHAP1", "gene_names_refseq": "ANP32A; ANP32D; HPPCn; LANP; PHAPI", "protein_names_uniprotkb": "Acidic leucine-rich nuclear phosphoprotein 32 family member A; LANP; Leucine-rich acidic nuclear protein; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A", "protein_names_refseq": "acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic (leucine-rich) nuclear phosphoprotein 32 family, member D; acidic leucine-rich nuclear phosphoprotein 32 family member A; hepatopoietin Cn; leucine-rich acidic nuclear protein; potent heat-stable protein phosphatase 2A inhibitor I1PP2A; putative HLA-DR-associated protein I", "tax_id": 9913, "disease": "", "pathway": " (bta:538427); (R-BTA-450520)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15895553;18306214;7937870;8679524", "class_list": "", "function": "HPPCn is a novel hepatic growth factor that plays a role in liver regeneration., [RefSeq, PubMed]; Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltransferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A., [UniProtKB, UniProtKB]; Multifunctional protein that is involved in the regulation of many processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P55930", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006913 nucleocytoplasmic transport;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P51122-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KHU3-1", "uniprot_id": [ { "id": "EXOS8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KHU3", "type": "external" } ], "mass": 29990.0, "length": 276, "protein_name": "Exosome complex component RRP43", "gene_name": "EXOSC8", "organism": "Bovine", "refseq_name": "exosome complex component RRP43", "refseq_ac": [ { "id": "NP_001073074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073074", "type": "external" } ], "gene_names_uniprotkb": "EXOSC8", "gene_names_refseq": "EXOSC8", "protein_names_uniprotkb": "Exosome complex component RRP43; Exosome component 8; Ribosomal RNA-processing protein 43", "protein_names_refseq": "exosome complex component RRP43; exosome complex exonuclease RRP43; ribosomal RNA-processing protein 43", "tax_id": 9913, "disease": "", "pathway": " (bta:532080); (R-BTA-429958); (R-BTA-450385); (R-BTA-450513); (R-BTA-450604); (R-BTA-6791226); (R-BTA-9930044)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0042802 identical protein binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0000176 nuclear exosome (RNase complex);GO:0000177 cytoplasmic exosome (RNase complex);GO:0000178 exosome (RNase complex);GO:0005654 nucleoplasm", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0034473 U1 snRNA 3'-end processing;GO:0034476 U5 snRNA 3'-end processing;GO:0016075 rRNA catabolic process;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KHU3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC68-1", "uniprot_id": [ { "id": "SEPT5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC68", "type": "external" } ], "mass": 42705.0, "length": 369, "protein_name": "Septin-5", "gene_name": "SEPTIN5", "organism": "Bovine", "refseq_name": "septin-5", "refseq_ac": [ { "id": "NP_001069839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069839", "type": "external" } ], "gene_names_uniprotkb": "SEPTIN5; SEPT5", "gene_names_refseq": "SEPT5; SEPTIN5", "protein_names_uniprotkb": "Septin-5", "protein_names_refseq": "septin-5", "tax_id": 9913, "disease": "", "pathway": " (bta:615408)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity)., [UniProtKB]; Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005940 septin ring;GO:0015630 microtubule cytoskeleton;GO:0008021 synaptic vesicle;GO:0098793 presynapse;GO:0031105 septin complex", "go_biological_process": "GO:0030534 adult behavior;GO:0035176 social behavior;GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0017157 regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC68-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62194-1", "uniprot_id": [ { "id": "PRS8_BOVIN", "url": "https://www.uniprot.org/uniprot/P62194", "type": "external" } ], "mass": 45626.0, "length": 406, "protein_name": "26S proteasome regulatory subunit 8", "gene_name": "PSMC5", "organism": "Bovine", "refseq_name": "26S proteasome regulatory subunit 8", "refseq_ac": [ { "id": "NP_776866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776866", "type": "external" } ], "gene_names_uniprotkb": "PSMC5; SUG1", "gene_names_refseq": "PSMC5", "protein_names_uniprotkb": "26S proteasome regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; Proteasome 26S subunit ATPase 5; Proteasome subunit p45; p45/SUG", "protein_names_refseq": "26S protease regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; 26S proteasome regulatory subunit 8; p45/SUG; proteasome (prosome, macropain) 26S subunit, ATPase, 5; proteasome subunit p45", "tax_id": 9913, "disease": "", "pathway": " (bta:282015); (R-BTA-1169091); (R-BTA-1234176); (R-BTA-1236978); (R-BTA-174084); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-187577); (R-BTA-195253); (R-BTA-202424); (R-BTA-2467813); (R-BTA-2871837); (R-BTA-349425); (R-BTA-350562); (R-BTA-382556); (R-BTA-450408); (R-BTA-4608870); (R-BTA-4641257); (R-BTA-4641258); (R-BTA-5358346); (R-BTA-5607761); (R-BTA-5607764); (R-BTA-5610780); (R-BTA-5610785); (R-BTA-5632684); (R-BTA-5668541); (R-BTA-5676590); (R-BTA-5687128); (R-BTA-5689603); (R-BTA-5689880); (R-BTA-68867); (R-BTA-68949); (R-BTA-69017); (R-BTA-69481); (R-BTA-69601); (R-BTA-75815); (R-BTA-8852276); (R-BTA-8854050); (R-BTA-8939236); (R-BTA-8939902); (R-BTA-8941858); (R-BTA-8948751); (R-BTA-8951664); (R-BTA-9020702); (R-BTA-9755511); (R-BTA-9762114); (R-BTA-9766229); (R-BTA-983168); (R-BTA-9907900); (R-BTA-9929356); (R-BTA-9929491); (R-BTA-9931269); (R-BTA-9932298); (R-BTA-9954709)", "pathway_count": 55, "publication_count": 1, "publication_id_list": "9701609", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H7C5;O35051;P47210;P52915;P52916", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140296 general transcription initiation factor binding;GO:0036402 proteasome-activating activity;GO:0031531 thyrotropin-releasing hormone receptor binding", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62194-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E15-1", "uniprot_id": [ { "id": "SIA7F_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E15", "type": "external" } ], "mass": 38034.0, "length": 332, "protein_name": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6", "gene_name": "ST6GALNAC6", "organism": "Bovine", "refseq_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6", "refseq_ac": [ { "id": "NP_001001151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001151", "type": "external" } ], "gene_names_uniprotkb": "ST6GALNAC6; SIAT7F", "gene_names_refseq": "ST6GALNAC6; siat7f; st6GalNAc-VI", "protein_names_uniprotkb": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; 2.4.99.-; GalNAc alpha-2,6-sialyltransferase VI; SIAT7-F; ST6GalNAc VI; ST6GalNAcVI; Sialyltransferase 7F", "protein_names_refseq": "SIAT7-F; ST6GalNAc VI; ST6GalNAcVI; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; beta-galactosamide alpha-2,6-sialyltransferase; galNAc alpha-2,6-sialyltransferase VI; sialyltransferase 7F; sialytransferase 7F", "tax_id": 9913, "disease": "", "pathway": " (bta:407222); (R-BTA-4085001); (R-BTA-9037629); (R-BTA-9840309)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "15843597", "class_list": "glycogene;glycosyltransferase", "function": "Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (By similarity). Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q704S2", "ec_number_list": [ { "id": "2.4.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.7", "type": "external" }, { "id": "2.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;GO:0008373 sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0009311 oligosaccharide metabolic process;GO:0001574 ganglioside biosynthetic process;GO:0009988 cell-cell recognition;GO:0006688 glycosphingolipid biosynthetic process", "synthesized_glycan_count": 550, "hit_score": 0.2, "record_id": "Q08E15-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81187-1", "uniprot_id": [ { "id": "CFAB_BOVIN", "url": "https://www.uniprot.org/uniprot/P81187", "type": "external" } ], "mass": 85366.0, "length": 761, "protein_name": "Complement factor B", "gene_name": "CFB", "organism": "Bovine", "refseq_name": "complement factor B precursor", "refseq_ac": [ { "id": "NP_001035616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035616", "type": "external" } ], "gene_names_uniprotkb": "CFB; BF", "gene_names_refseq": "BF; CFB", "protein_names_uniprotkb": "Complement factor B; 3.4.21.47; C3/C5 convertase; EC-VMFB", "protein_names_refseq": "C3/C5 convertase; EC-VMFB; complement component factor B; complement factor B precursor; properdin factor B", "tax_id": 9913, "disease": "", "pathway": " (bta:514076); (R-BTA-173736); (R-BTA-174577); (R-BTA-977606)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9281322", "class_list": "", "function": "Involved in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Precursor of the catalytic component of the C3 and C5 convertase complexes of the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The alternative complement pathway acts as an amplification loop that enhances other complement pathways (classical, lectin and GZMK) by promoting formation of additional C3 and C5 convertases. CFB is cleaved and activated by CFD to generate Ba and Bb chains; Bb chain constituting the catalytic component of the C3 and C5 convertases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Serine protease component of the complement C3 and C5 convertase complexes of the alternative complement pathway. Following cleavage and activation by factor D (CFD), forms the C3 convertase together with complement C3b. As part of the C3 convertase, cleaves and activates C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. When an additional complement C3b molecule binds to the C3 convertase, forms the C5 convertase, which cleaves and activates C5 into C5a anaphylatoxin and C5b component of the membrane attack complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q2KIU6", "ec_number_list": [ { "id": "3.4.21.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.47", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0006508 proteolysis;GO:0009617 response to bacterium;GO:0006957 complement activation, alternative pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P81187-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29S22-1", "uniprot_id": [ { "id": "DDX47_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29S22", "type": "external" } ], "mass": 50913.0, "length": 457, "protein_name": "Probable ATP-dependent RNA helicase DDX47", "gene_name": "DDX47", "organism": "Bovine", "refseq_name": "probable ATP-dependent RNA helicase DDX47", "refseq_ac": [ { "id": "NP_001039850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039850", "type": "external" } ], "gene_names_uniprotkb": "DDX47", "gene_names_refseq": "DDX47", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX47; 3.6.4.13; DEAD box protein 47", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 47; DEAD box protein 47; probable ATP-dependent RNA helicase DDX47", "tax_id": 9913, "disease": "", "pathway": " (bta:534721); (R-BTA-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "41018975", "class_list": "", "function": "Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006364 rRNA processing;GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q29S22-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QK3-1", "uniprot_id": [ { "id": "CBPQ_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QK3", "type": "external" } ], "mass": 51679.0, "length": 472, "protein_name": "Carboxypeptidase Q", "gene_name": "CPQ", "organism": "Bovine", "refseq_name": "carboxypeptidase Q precursor", "refseq_ac": [ { "id": "NP_001069716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069716", "type": "external" } ], "gene_names_uniprotkb": "CPQ; PGCP", "gene_names_refseq": "CPQ; PGCP", "protein_names_uniprotkb": "Carboxypeptidase Q; 3.4.17.-; Plasma glutamate carboxypeptidase", "protein_names_refseq": "carboxypeptidase Q precursor; plasma glutamate carboxypeptidase", "tax_id": 9913, "disease": "", "pathway": " (bta:540923)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0070573 metallodipeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process;GO:0042246 tissue regeneration;GO:0006590 thyroid hormone generation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q17QK3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJI3-1", "uniprot_id": [ { "id": "CYRIB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJI3", "type": "external" } ], "mass": 36748.0, "length": 324, "protein_name": "CYFIP-related Rac1 interactor B", "gene_name": "CYRIB", "organism": "Bovine", "refseq_name": "CYFIP-related Rac1 interactor B", "refseq_ac": [ { "id": "NP_001039512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039512", "type": "external" } ], "gene_names_uniprotkb": "CYRIB; FAM49B", "gene_names_refseq": "CYRIB; FAM49B", "protein_names_uniprotkb": "CYFIP-related Rac1 interactor B; Protein FAM49B", "protein_names_refseq": "CYFIP-related Rac1 interactor B; family with sequence similarity 49 member B; protein FAM49B", "tax_id": 9913, "disease": "", "pathway": " (bta:510019); (R-BTA-114608)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling. Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization. Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (By similarity). Also restricts infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0023030 MHC class Ib protein binding, via antigen binding groove", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0090140 regulation of mitochondrial fission;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0030334 regulation of cell migration;GO:0032729 positive regulation of type II interferon production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJI3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMW5-1", "uniprot_id": [ { "id": "GRB7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMW5", "type": "external" } ], "mass": 59653.0, "length": 532, "protein_name": "Growth factor receptor-bound protein 7", "gene_name": "GRB7", "organism": "Bovine", "refseq_name": "growth factor receptor-bound protein 7", "refseq_ac": [ { "id": "NP_001039479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039479", "type": "external" } ], "gene_names_uniprotkb": "GRB7", "gene_names_refseq": "GRB7", "protein_names_uniprotkb": "Growth factor receptor-bound protein 7; Epidermal growth factor receptor GRB-7; GRB7 adapter protein", "protein_names_refseq": "GRB7 adapter protein; epidermal growth factor receptor GRB-7; growth factor receptor-bound protein 7", "tax_id": 9913, "disease": "", "pathway": " (bta:508847); (R-BTA-1306955); (R-BTA-1433557); (R-BTA-186763); (R-BTA-210993); (R-BTA-8853659); (R-BTA-9696273)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0030674 protein-macromolecule adaptor activity;GO:0035091 phosphatidylinositol binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0042995 cell projection;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0017148 negative regulation of translation;GO:0034063 stress granule assembly;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMW5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCY1-1", "uniprot_id": [ { "id": "VAPA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCY1", "type": "external" } ], "mass": 27856.0, "length": 249, "protein_name": "Vesicle-associated membrane protein-associated protein A", "gene_name": "VAPA", "organism": "Bovine", "refseq_name": "vesicle-associated membrane protein-associated protein A", "refseq_ac": [ { "id": "NP_001069201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069201", "type": "external" } ], "gene_names_uniprotkb": "VAPA", "gene_names_refseq": "VAPA", "protein_names_uniprotkb": "Vesicle-associated membrane protein-associated protein A; VAMP-A; VAMP-associated protein A; VAP-A", "protein_names_refseq": "VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; VAMP-A; VAP-A; vesicle-associated membrane protein-associated protein A", "tax_id": 9913, "disease": "", "pathway": " (bta:516024); (R-BTA-1660661); (R-BTA-6798695); (R-BTA-9609523)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0033149 FFAT motif binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0005789 endoplasmic reticulum membrane;GO:0000139 Golgi membrane", "go_biological_process": "GO:0031175 neuron projection development;GO:0070972 protein localization to endoplasmic reticulum;GO:0006686 sphingomyelin biosynthetic process;GO:0044829 host-mediated activation of viral genome replication;GO:0035627 ceramide transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCY1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ92-1", "uniprot_id": [ { "id": "PRKRA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ92", "type": "external" } ], "mass": 34413.0, "length": 313, "protein_name": "Interferon-inducible double-stranded RNA-dependent protein kinase activator A", "gene_name": "PRKRA", "organism": "Bovine", "refseq_name": "interferon-inducible double-stranded RNA-dependent protein kinase activator A", "refseq_ac": [ { "id": "NP_001039335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039335", "type": "external" } ], "gene_names_uniprotkb": "PRKRA", "gene_names_refseq": "PACT; PRKRA", "protein_names_uniprotkb": "Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double-stranded RNA-dependent activator", "protein_names_refseq": "interferon-inducible double-stranded RNA-dependent protein kinase activator A; protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double-stranded RNA-dependent activator", "tax_id": 9913, "disease": "", "pathway": " (bta:282875); (R-BTA-203927); (R-BTA-426486); (R-BTA-9833482)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "12440939", "class_list": "", "function": "Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). May function as regulator of gastric epithelial differentiation (By similarity)., [UniProtKB, UniProtKB]; Tumour necrosis factor alpha up-regulates protein kinase R (PKR)-activating protein (PACT, PRKRA) and increases phosphorylation of PKR and eukaryotic initiation factor 2-alpha in articular chondrocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0035197 siRNA binding;GO:0003723 RNA binding;GO:0008047 enzyme activator activity;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005622 intracellular anatomical structure;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0016442 RISC complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0048705 skeletal system morphogenesis;GO:0030422 siRNA processing;GO:0042474 middle ear morphogenesis;GO:0042473 outer ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2HJ92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMX9-1", "uniprot_id": [ { "id": "DCNL5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMX9", "type": "external" } ], "mass": 27362.0, "length": 236, "protein_name": "DCN1-like protein 5", "gene_name": "DCUN1D5", "organism": "Bovine", "refseq_name": "DCN1-like protein 5", "refseq_ac": [ { "id": "NP_001039477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039477", "type": "external" } ], "gene_names_uniprotkb": "DCUN1D5", "gene_names_refseq": "DCUN1D5", "protein_names_uniprotkb": "DCN1-like protein 5; DCUN1 domain-containing protein 5; Defective in cullin neddylation protein 1-like protein 5; Squamous cell carcinoma-related oncogene 5", "protein_names_refseq": "CG6597-PA like; DCN1, defective in cullin neddylation 1, domain containing 5; DCN1-like protein 5; DCUN1 domain-containing protein 5; defective in cullin neddylation protein 1-like protein 5; squamous cell carcinoma-related oncogene 5", "tax_id": 9913, "disease": "", "pathway": " (bta:508759); (R-BTA-8951664)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032182 ubiquitin-like protein binding;GO:0097602 cullin family protein binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0001558 regulation of cell growth;GO:0045116 protein neddylation;GO:2000436 positive regulation of protein neddylation;GO:2000434 regulation of protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMX9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28104-1", "uniprot_id": [ { "id": "COPE_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28104", "type": "external" } ], "mass": 34481.0, "length": 308, "protein_name": "Coatomer subunit epsilon", "gene_name": "COPE", "organism": "Bovine", "refseq_name": "coatomer subunit epsilon", "refseq_ac": [ { "id": "NP_788846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788846", "type": "external" } ], "gene_names_uniprotkb": "COPE; COPE1", "gene_names_refseq": "COPE", "protein_names_uniprotkb": "Coatomer subunit epsilon; Epsilon-COP; Epsilon-coat protein", "protein_names_refseq": "coatomer protein complex subunit epsilon; coatomer subunit epsilon; epsilon subunit of coatomer protein complex; epsilon-COP; epsilon-coat protein", "tax_id": 9913, "disease": "", "pathway": " (bta:338085); (R-BTA-6807878); (R-BTA-6811434)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16305752;8132710", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L5B2;Q2TBL7;Q9N286", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030126 COPI vesicle coat;GO:0030663 COPI-coated vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28104-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCL3-1", "uniprot_id": [ { "id": "ATG3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCL3", "type": "external" } ], "mass": 35752.0, "length": 314, "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "ATG3", "organism": "Bovine", "refseq_name": "ubiquitin-like-conjugating enzyme ATG3", "refseq_ac": [ { "id": "NP_001068832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068832", "type": "external" } ], "gene_names_uniprotkb": "ATG3", "gene_names_refseq": "ATG3", "protein_names_uniprotkb": "Ubiquitin-like-conjugating enzyme ATG3; 2.3.2.-; APG3-like; Autophagy-related protein 3", "protein_names_refseq": "ATG3 autophagy related 3 homolog; autophagy-related protein 3; ubiquitin-like-conjugating enzyme ATG3", "tax_id": 9913, "disease": "", "pathway": " (bta:508571); (R-BTA-1632852)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the covalent conjugation of the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to the amino group of phosphatidylethanolamine (PE)-containing lipids in the membrane resulting in membrane-bound ATG8-like proteins which is one of the key steps in the development of autophagic isolation membranes during autophagosome formation. Cycles back and forth between binding to ATG7 for loading with the ATG8-like proteins and binding to E3 enzyme, composed of ATG12, ATG5 and ATG16L1 to promote ATG8-like proteins lipidation (By similarity). Also plays a role as a membrane curvature sensor that facilitates LC3/GABARAP lipidation by sensing local membrane stress associated with lipid-packing defects as occurs with high molar proportions of conical lipids or strident membrane curvature (By similarity). Interacts with negatively-charged membranes promoting membrane tethering and enhancing LC3/GABARAP lipidation (By similarity). Also acts as an autocatalytic E2-like enzyme by catalyzing the conjugation of ATG12 to itself in an ATG7-dependent manner, this complex thus formed, plays a role in mitochondrial homeostasis but not in autophagy. ATG12-ATG3 conjugation promotes late endosome to lysosome trafficking and basal autophagosome maturation via its interaction with PDCD6IP. ATG12-ATG3 conjugate is also formed upon viccina virus infection, leading to the disruption the cellular autophagy which is not necessary for vaccinia survival and proliferation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019776 Atg8-family ligase activity;GO:0019777 Atg12 transferase activity;GO:0141046 Atg8-family conjugating enzyme activity;GO:0019787 ubiquitin-like protein transferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000407 phagophore assembly site;GO:0034274 Atg12-Atg5-Atg16 complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0006914 autophagy;GO:0016567 protein ubiquitination;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCL3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05588-1", "uniprot_id": [ { "id": "UPAR_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05588", "type": "external" } ], "mass": 35989.0, "length": 330, "protein_name": "Urokinase plasminogen activator surface receptor", "gene_name": "PLAUR", "organism": "Bovine", "refseq_name": "urokinase plasminogen activator surface receptor precursor", "refseq_ac": [ { "id": "NP_776848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776848", "type": "external" } ], "gene_names_uniprotkb": "PLAUR", "gene_names_refseq": "PLAUR", "protein_names_uniprotkb": "Urokinase plasminogen activator surface receptor; U-PAR; uPAR", "protein_names_refseq": "U-PAR; uPAR; urokinase plasminogen activator surface receptor precursor; urokinase plasminogen activator surface receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281983); (R-BTA-162791); (R-BTA-6798695); (R-BTA-75205); (R-BTA-9855719); (R-BTA-9970672)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "12665524;22103977;23951261;24981429;25939353;8122188;8385052", "class_list": "", "function": "Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC). Erratum:[PLoS One. 2017 Oct 16;12(10):e0186749. doi: 10.1371/journal.pone.0186749. PMID: 29036233] Publication Status: Online-Only, [RefSeq, PubMed]; Data show that urokinase-type plasminogen activator (uPA) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1) are expressed in both the cumulus cells and the immature and in vitro matured oocytes., [RefSeq, PubMed]; GPI-anchored receptor that recruits and activates the urokinase-type plasminogen activator (uPA) at the cell surface. Activated uPA converts plasminogen into plasmin, initiating extracellular matrix degradation and remodeling. Also binds the extracellular matrix protein vitronectin, promoting cell-matrix adhesion and indirectly integrin signaling. This dual interaction coordinates dynamic changes in cell migration, proliferation, and tissue remodeling., [UniProtKB, UniProtKB]; The interaction between uPAR and Man-6-P/IGF2R is a low percentage binding event and that suPAR and full-length uPAR bind the Man-6-P/IGF2R by different mechanisms., [RefSeq, PubMed]; These data indicated that E. coli LPS led to an increase in u-PA activity and RNA expression of u-PA and u-PAR in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes., [RefSeq, PubMed]; UPA/uPAR binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A5PJ83", "ec_number_list": [], "go_molecular_function": "GO:0030377 urokinase plasminogen activator receptor activity;GO:0005102 signaling receptor binding;GO:0019904 protein domain specific binding;GO:0035375 zymogen binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045177 apical part of cell;GO:0098552 side of membrane", "go_biological_process": "GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway;GO:0031639 plasminogen activation;GO:0090200 positive regulation of release of cytochrome c from mitochondria;GO:0034112 positive regulation of homotypic cell-cell adhesion;GO:0034394 protein localization to cell surface", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q05588-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9S6-1", "uniprot_id": [ { "id": "RHCG_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9S6", "type": "external" } ], "mass": 50834.0, "length": 460, "protein_name": "Ammonium transporter Rh type C", "gene_name": "RHCG", "organism": "Bovine", "refseq_name": "ammonium transporter Rh type C", "refseq_ac": [ { "id": "NP_776597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776597", "type": "external" } ], "gene_names_uniprotkb": "RHCG", "gene_names_refseq": "RHCG", "protein_names_uniprotkb": "Ammonium transporter Rh type C; Rh family type C glycoprotein; Rh type C glycoprotein; Rhesus blood group family type C glycoprotein", "protein_names_refseq": "Rh type C glycoprotein; ammonium transporter Rh type C; rh family type C glycoprotein; rhesus blood group family type C glycoprotein", "tax_id": 9913, "disease": "", "pathway": " (bta:281456); (R-BTA-444411)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11358367", "class_list": "", "function": "Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (By similarity). May act as a CO2 channel providing for renal acid secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95M76", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008519 ammonium channel activity;GO:0035379 carbon dioxide transmembrane transporter activity;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0097272 ammonium homeostasis;GO:0070634 transepithelial ammonium transport;GO:0006873 intracellular monoatomic ion homeostasis;GO:0072488 ammonium transmembrane transport;GO:0006885 regulation of pH", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2T9S6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCM4-1", "uniprot_id": [ { "id": "PYGL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCM4", "type": "external" } ], "mass": 97456.0, "length": 851, "protein_name": "Glycogen phosphorylase, liver form", "gene_name": "PYGL", "organism": "Bovine", "refseq_name": "glycogen phosphorylase, liver form", "refseq_ac": [ { "id": "NP_001068671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068671", "type": "external" } ], "gene_names_uniprotkb": "PYGL", "gene_names_refseq": "PYGL", "protein_names_uniprotkb": "Glycogen phosphorylase, liver form; 2.4.1.1", "protein_names_refseq": "glycogen phosphorylase, liver form; liver (Hers disease, glycogen storage disease type VI); liver glycogen phosphorylase; phosphorylase, glycogen, liver; phosphorylase, glycogen", "tax_id": 9913, "disease": "", "pathway": " (bta:505472); (R-BTA-6798695); (R-BTA-70221)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0000166 nucleotide binding;GO:0008184 glycogen phosphorylase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0005980 glycogen catabolic process;GO:0042593 glucose homeostasis;GO:0005977 glycogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCM4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIF7-1", "uniprot_id": [ { "id": "UBP14_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIF7", "type": "external" } ], "mass": 56013.0, "length": 494, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 14", "gene_name": "USP14", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 14", "refseq_ac": [ { "id": "NP_001068657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068657", "type": "external" } ], "gene_names_uniprotkb": "USP14", "gene_names_refseq": "USP14", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 14; 3.4.19.12; Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14", "protein_names_refseq": "deubiquitinating enzyme 14; ubiquitin carboxyl-terminal hydrolase 14; ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); ubiquitin thioesterase 14; ubiquitin thiolesterase 14; ubiquitin-specific-processing protease 14", "tax_id": 9913, "disease": "", "pathway": " (bta:505106); (R-BTA-5689880); (R-BTA-9758274)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "18162577", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (By similarity). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070628 proteasome binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0000502 proteasome complex;GO:0098978 glutamatergic synapse;GO:0099523 presynaptic cytosol", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0045087 innate immune response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:1904293 negative regulation of ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0IIF7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJF8-1", "uniprot_id": [ { "id": "MIRO1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJF8", "type": "external" } ], "mass": 72078.0, "length": 631, "protein_name": "Mitochondrial Rho GTPase 1", "gene_name": "RHOT1", "organism": "Bovine", "refseq_name": "mitochondrial Rho GTPase 1", "refseq_ac": [ { "id": "NP_001039547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039547", "type": "external" } ], "gene_names_uniprotkb": "RHOT1; ARHT1", "gene_names_refseq": "RHOT1", "protein_names_uniprotkb": "Mitochondrial Rho GTPase 1; 3.6.5.-; MIRO-1; Ras homolog gene family member T1", "protein_names_refseq": "MIRO-1; mitochondrial Rho GTPase 1; ras homolog gene family, member T1", "tax_id": 9913, "disease": "", "pathway": " (bta:511257); (R-BTA-5689880); (R-BTA-9013425)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Promotes mitochondrial fission during high calcium conditions. Can hydrolyze GTP, ATP and UTP (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0019725 cellular homeostasis;GO:0007005 mitochondrion organization;GO:0097345 mitochondrial outer membrane permeabilization;GO:0034643 establishment of mitochondrion localization, microtubule-mediated", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJF8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DD1-1", "uniprot_id": [ { "id": "ARSA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DD1", "type": "external" } ], "mass": 53807.0, "length": 507, "protein_name": "Arylsulfatase A", "gene_name": "ARSA", "organism": "Bovine", "refseq_name": "arylsulfatase A precursor", "refseq_ac": [ { "id": "NP_001068673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068673", "type": "external" } ], "gene_names_uniprotkb": "ARSA", "gene_names_refseq": "ARSA", "protein_names_uniprotkb": "Arylsulfatase A; 3.1.6.8; ASA; Cerebroside-sulfatase", "protein_names_refseq": "ASA; arylsulfatase A precursor; cerebroside-sulfatase", "tax_id": 9913, "disease": "", "pathway": " (bta:505514); (R-BTA-1663150); (R-BTA-6798695); (R-BTA-9840310)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes cerebroside sulfate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.8.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.7", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004065 arylsulfatase activity;GO:0004098 cerebroside-sulfatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DD1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ44-1", "uniprot_id": [ { "id": "GLD2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ44", "type": "external" } ], "mass": 56051.0, "length": 484, "protein_name": "Poly(A) RNA polymerase GLD2", "gene_name": "TENT2", "organism": "Bovine", "refseq_name": "poly(A) RNA polymerase GLD2", "refseq_ac": [ { "id": "NP_001039826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039826", "type": "external" } ], "gene_names_uniprotkb": "TENT2", "gene_names_refseq": "PAPD4; TENT2", "protein_names_uniprotkb": "Poly(A) RNA polymerase GLD2; 2.7.7.19; PAP-associated domain-containing protein 4", "protein_names_refseq": "PAP associated domain containing 4; PAP-associated domain-containing protein 4; poly(A) RNA polymerase D4, non-canonical; poly(A) RNA polymerase GLD2", "tax_id": 9913, "disease": "", "pathway": " (bta:533862)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1JPF9", "ec_number_list": [ { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071044 histone mRNA catabolic process;GO:0031124 mRNA 3'-end processing;GO:0031123 RNA 3'-end processing;GO:2000626 negative regulation of miRNA catabolic process;GO:0140958 target-directed miRNA degradation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2HJ44-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2LL38-1", "uniprot_id": [ { "id": "AAKG3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2LL38", "type": "external" } ], "mass": 54920.0, "length": 497, "protein_name": "5'-AMP-activated protein kinase subunit gamma-3", "gene_name": "PRKAG3", "organism": "Bovine", "refseq_name": "5'-AMP-activated protein kinase subunit gamma-3 isoform 1", "refseq_ac": [ { "id": "NP_001025473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025473", "type": "external" } ], "gene_names_uniprotkb": "PRKAG3", "gene_names_refseq": "PRKAG3", "protein_names_uniprotkb": "5'-AMP-activated protein kinase subunit gamma-3; AMPK gamma3; AMPK subunit gamma-3", "protein_names_refseq": "5'-AMP-activated protein kinase gamma-3 subunit; 5'-AMP-activated protein kinase subunit gamma-3 isoform 1; 5'-AMP-activated protein kinase subunit gamma-3; AMP-activated protein kinase gamma; AMPK gamma-3 chain; AMPK gamma3; AMPK subunit gamma-3", "tax_id": 9913, "disease": "", "pathway": " (bta:511961); (R-BTA-1632852); (R-BTA-380972); (R-BTA-5628897); (R-BTA-6804756); (R-BTA-9931269)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "16416094;21954624", "class_list": "", "function": "AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism. It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive., [UniProtKB, UniProtKB]; Association between polymorphism in bovine PRKAG3 gene and milk production traits., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2LL34;Q2LL35;Q2LL36;Q2LL37;Q2LL39;Q2LL40;Q2LL41", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0016208 AMP binding;GO:0019887 protein kinase regulator activity;GO:0004679 AMP-activated protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031588 nucleotide-activated protein kinase complex", "go_biological_process": "GO:0006110 regulation of glycolytic process;GO:0006633 fatty acid biosynthetic process;GO:0042149 cellular response to glucose starvation;GO:0045722 positive regulation of gluconeogenesis;GO:0031669 cellular response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2LL38-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61267-1", "uniprot_id": [ { "id": "STX1B_BOVIN", "url": "https://www.uniprot.org/uniprot/P61267", "type": "external" } ], "mass": 33275.0, "length": 288, "protein_name": "Syntaxin-1B", "gene_name": "STX1B", "organism": "Bovine", "refseq_name": "syntaxin-1B", "refseq_ac": [ { "id": "NP_777043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777043", "type": "external" } ], "gene_names_uniprotkb": "STX1B; STX1B2", "gene_names_refseq": "STX1B2; STX1B", "protein_names_uniprotkb": "Syntaxin-1B; Synaptocanalin I; Syntaxin-1B2", "protein_names_refseq": "synaptocanalin I; syntaxin 1B2; syntaxin-1B", "tax_id": 9913, "disease": "", "pathway": " (bta:282377); (R-BTA-5682910)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "8455717;8611567", "class_list": "", "function": "Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QR58;P41414", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity;GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0031201 SNARE complex;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0048278 vesicle docking;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61267-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJH1-1", "uniprot_id": [ { "id": "DNPEP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJH1", "type": "external" } ], "mass": 51828.0, "length": 471, "protein_name": "Aspartyl aminopeptidase", "gene_name": "DNPEP", "organism": "Bovine", "refseq_name": "aspartyl aminopeptidase", "refseq_ac": [ { "id": "NP_001039417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039417", "type": "external" } ], "gene_names_uniprotkb": "DNPEP", "gene_names_refseq": "DNPEP", "protein_names_uniprotkb": "Aspartyl aminopeptidase; 3.4.11.21", "protein_names_refseq": "aspartyl aminopeptidase", "tax_id": 9913, "disease": "", "pathway": " (bta:506882)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22356908", "class_list": "", "function": "Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; DNPEP assembles into a functionally relevant tetrahedral complex that restricts access of peptide substrates to the active site., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2HJH1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58353-1", "uniprot_id": [ { "id": "GTR5_BOVIN", "url": "https://www.uniprot.org/uniprot/P58353", "type": "external" } ], "mass": 55393.0, "length": 501, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 5", "gene_name": "LOC107131287; SLC2A5", "organism": "Bovine", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 5", "refseq_ac": [ { "id": "NP_001094512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094512", "type": "external" } ], "gene_names_uniprotkb": "LOC107131287; SLC2A5; GLUT5", "gene_names_refseq": "GLUT5; SLC2A5", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; GLUT-5; Glucose transporter type 5, small intestine", "protein_names_refseq": "GLUT-5; fructose transporter; glucose transporter type 5, small intestine; solute carrier family 2, facilitated glucose transporter member 5", "tax_id": 9913, "disease": "", "pathway": " (bta:282868); (R-BTA-6798695); (R-BTA-8981373)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11599048;26416735", "class_list": "", "function": "Crystal structures of GLUT5 from Rattus norvegicus and Bos taurus in open outward- and open inward-facing conformations, respectively, [RefSeq, PubMed]; Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A7MBF2", "ec_number_list": [], "go_molecular_function": "GO:0070061 fructose binding;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:0009750 response to fructose;GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal;GO:0015755 fructose transmembrane transport;GO:0071332 cellular response to fructose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P58353-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29627-1", "uniprot_id": [ { "id": "PACR_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29627", "type": "external" } ], "mass": 58785.0, "length": 513, "protein_name": "Pituitary adenylate cyclase-activating polypeptide type I receptor", "gene_name": "ADCYAP1R1", "organism": "Bovine", "refseq_name": "pituitary adenylate cyclase-activating polypeptide type I receptor precursor", "refseq_ac": [ { "id": "NP_783646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783646", "type": "external" } ], "gene_names_uniprotkb": "ADCYAP1R1", "gene_names_refseq": "ADCYAP1R1; PACAPR", "protein_names_uniprotkb": "Pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP type I receptor; PACAP-R-1; PACAP-R1", "protein_names_refseq": "PACAP type I receptor; PACAP-R-1; PACAP-R1; adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; pituitary adenylate cyclase-activating polypeptide type I receptor precursor; pituitary adenylate cyclase-activating polypeptide type I receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:319095); (R-BTA-418555); (R-BTA-420092)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8049255", "class_list": "", "function": "G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001634 pituitary adenylate cyclase-activating polypeptide receptor activity;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004999 vasoactive intestinal polypeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q29627-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JQA2-1", "uniprot_id": [ { "id": "SMAD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JQA2", "type": "external" } ], "mass": 52250.0, "length": 465, "protein_name": "SMAD family member 1", "gene_name": "SMAD1", "organism": "Bovine", "refseq_name": "SMAD family member 1", "refseq_ac": [ { "id": "NP_001069691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069691", "type": "external" } ], "gene_names_uniprotkb": "SMAD1", "gene_names_refseq": "SMAD1", "protein_names_uniprotkb": "SMAD family member 1; MAD homolog 1; Mothers against DPP homolog 1; Mothers against decapentaplegic homolog 1; SMAD 1", "protein_names_refseq": "MAD homolog 1; SMAD 1; SMAD family member 1; SMAD, mothers against DPP homolog 1; Sma- and Mad-related protein 1; mad-related protein 1; mothers against decapentaplegic homolog 1", "tax_id": 9913, "disease": "", "pathway": " (bta:540488); (R-BTA-201451); (R-BTA-5689880); (R-BTA-8941326)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "23804438;35093446", "class_list": "", "function": "A detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7. Publication Status: Online-Only, [RefSeq, PubMed]; Effect of genetic variants in the SMAD1 and SMAD5 genes promoter on growth and beef quality traits in cattle., [RefSeq, PubMed]; Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q06AL6", "ec_number_list": [], "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1JQA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54149-1", "uniprot_id": [ { "id": "MSRA_BOVIN", "url": "https://www.uniprot.org/uniprot/P54149", "type": "external" } ], "mass": 25818.0, "length": 233, "protein_name": "Mitochondrial peptide methionine sulfoxide reductase", "gene_name": "MSRA", "organism": "Bovine", "refseq_name": "mitochondrial peptide methionine sulfoxide reductase", "refseq_ac": [ { "id": "NP_776539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776539", "type": "external" } ], "gene_names_uniprotkb": "MSRA", "gene_names_refseq": "MSRA", "protein_names_uniprotkb": "Mitochondrial peptide methionine sulfoxide reductase; 1.8.4.11; Peptide Met(O) reductase; Peptide-methionine (S)-S-oxide reductase; Protein-methionine-S-oxide reductase", "protein_names_refseq": "mitochondrial peptide methionine sulfoxide reductase; peptide Met(O) reductase; peptide methionine sulfoxide reductase; peptide-methionine (S)-S-oxide reductase; protein-methionine-S-oxide reductase", "tax_id": 9913, "disease": "", "pathway": " (bta:281312); (R-BTA-5676934)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11063566;16305752;16735467;32586239;8700890", "class_list": "", "function": "Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Has an important function as a repair enzyme for proteins that have been inactivated by oxidation (PubMed:8700890). Plays a crucial role in repairing oxidized methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens transparency (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Molecular Expression of Bioactive Recombinant Methionine Sulfoxide Reductase A (MsrA)., [RefSeq, PubMed]; The results indicate that thionein (T), which is formed when the zinc is removed from zinc-containing metallothionein (Zn-MT), can function as a reducing system for the Msr proteins because of its high content of cysteine residues., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZC16;Q5E976", "ec_number_list": [ { "id": "1.8.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.11", "type": "external" } ], "go_molecular_function": "GO:0008113 peptide-methionine (S)-S-oxide reductase activity;GO:0033744 L-methionine:thioredoxin-disulfide S-oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P54149-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QH6-1", "uniprot_id": [ { "id": "COL11_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QH6", "type": "external" } ], "mass": 28333.0, "length": 267, "protein_name": "Collectin-11", "gene_name": "COLEC11", "organism": "Bovine", "refseq_name": "collectin-11 precursor", "refseq_ac": [ { "id": "NP_001069771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069771", "type": "external" } ], "gene_names_uniprotkb": "COLEC11", "gene_names_refseq": "COLEC11", "protein_names_uniprotkb": "Collectin-11; CL-K1; Collectin kidney protein 1", "protein_names_refseq": "CL-K1; collectin kidney protein 1; collectin sub-family member 11; collectin-11 precursor; collectin-11", "tax_id": 9913, "disease": "", "pathway": " (bta:613991); (R-BTA-166662); (R-BTA-3000480)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005537 D-mannose binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0032502 developmental process;GO:0019730 antimicrobial humoral response;GO:0001867 complement activation, lectin pathway;GO:1903028 positive regulation of opsonization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q17QH6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RQ5-1", "uniprot_id": [ { "id": "TRIM9_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RQ5", "type": "external" } ], "mass": 79347.0, "length": 710, "protein_name": "E3 ubiquitin-protein ligase TRIM9", "gene_name": "TRIM9", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase TRIM9", "refseq_ac": [ { "id": "NP_001070005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070005", "type": "external" } ], "gene_names_uniprotkb": "TRIM9", "gene_names_refseq": "TRIM9", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM9; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM9; Tripartite motif-containing protein 9", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM9; RING-type E3 ubiquitin transferase TRIM9; tripartite motif-containing protein 9", "tax_id": 9913, "disease": "", "pathway": " (bta:767615); (R-BTA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030425 dendrite;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RQ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBQ7-1", "uniprot_id": [ { "id": "RMD2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBQ7", "type": "external" } ], "mass": 47067.0, "length": 410, "protein_name": "Regulator of microtubule dynamics protein 2", "gene_name": "RMDN2", "organism": "Bovine", "refseq_name": "regulator of microtubule dynamics protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001035598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035598", "type": "external" } ], "gene_names_uniprotkb": "RMDN2; FAM82A1; FAM82A", "gene_names_refseq": "FAM82A1; FAM82A; RMD-2; RMDN2", "protein_names_uniprotkb": "Regulator of microtubule dynamics protein 2; Protein FAM82A1; RMD-2", "protein_names_refseq": "family with sequence similarity 82, member A1; family with sequence similarity 82, member A; regulator of microtubule dynamics protein 2 isoform 1; regulator of microtubule dynamics protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:506362)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016020 membrane;GO:0005876 spindle microtubule;GO:0097431 mitotic spindle pole", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBQ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61283-1", "uniprot_id": [ { "id": "BAF_BOVIN", "url": "https://www.uniprot.org/uniprot/P61283", "type": "external" } ], "mass": 10059.0, "length": 89, "protein_name": "Barrier-to-autointegration factor", "gene_name": "BANF1", "organism": "Bovine", "refseq_name": "barrier-to-autointegration factor", "refseq_ac": [ { "id": "NP_892033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_892033", "type": "external" } ], "gene_names_uniprotkb": "BANF1; BAF", "gene_names_refseq": "BANF1", "protein_names_uniprotkb": "Barrier-to-autointegration factor", "protein_names_refseq": "barrier to autointegration factor 1; barrier-to-autointegration factor", "tax_id": 9913, "disease": "", "pathway": " (bta:360196); (R-BTA-2980766); (R-BTA-2995383)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA. Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging. Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner. Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface. Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity. Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses. Also involved in DNA damage response: interacts with PARP1 in response to oxidative stress, thereby inhibiting the ADP-ribosyltransferase activity of PARP1. Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy. In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5E9E5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042803 protein homodimerization activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0000793 condensed chromosome;GO:0000785 chromatin", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006325 chromatin organization;GO:0007084 mitotic nuclear membrane reassembly;GO:0010836 negative regulation of protein ADP-ribosylation;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61283-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ32-1", "uniprot_id": [ { "id": "SBP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ32", "type": "external" } ], "mass": 52555.0, "length": 472, "protein_name": "Methanethiol oxidase", "gene_name": "SELENBP1", "organism": "Bovine", "refseq_name": "methanethiol oxidase", "refseq_ac": [ { "id": "NP_001039513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039513", "type": "external" } ], "gene_names_uniprotkb": "SELENBP1; SBP", "gene_names_refseq": "MTO; SELENBP1", "protein_names_uniprotkb": "Methanethiol oxidase; 1.8.3.4; 56 kDa selenium-binding protein; MTO; SBP56; SP56; Selenium-binding protein 1", "protein_names_refseq": "56 kDa selenium-binding protein; SBP56; SP56; methanethiol oxidase", "tax_id": 9913, "disease": "", "pathway": " (bta:510154)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10799528", "class_list": "", "function": "Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.4", "type": "external" } ], "go_molecular_function": "GO:0008430 selenium binding;GO:0018549 methanethiol oxidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005730 nucleolus", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KJ32-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DK3-1", "uniprot_id": [ { "id": "KLH20_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DK3", "type": "external" } ], "mass": 67955.0, "length": 609, "protein_name": "Kelch-like protein 20", "gene_name": "KLHL20", "organism": "Bovine", "refseq_name": "kelch-like protein 20", "refseq_ac": [ { "id": "NP_001070303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070303", "type": "external" } ], "gene_names_uniprotkb": "KLHL20", "gene_names_refseq": "KLHL20", "protein_names_uniprotkb": "Kelch-like protein 20", "protein_names_refseq": "kelch-like 20; kelch-like protein 20", "tax_id": 9913, "disease": "", "pathway": " (bta:511387); (R-BTA-8951664); (R-BTA-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0019964 type II interferon binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0043066 negative regulation of apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DK3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QN3-1", "uniprot_id": [ { "id": "RSMN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QN3", "type": "external" } ], "mass": 24622.0, "length": 240, "protein_name": "Small nuclear ribonucleoprotein-associated protein N", "gene_name": "SNRPN", "organism": "Bovine", "refseq_name": "small nuclear ribonucleoprotein-associated protein N", "refseq_ac": [ { "id": "NP_001073265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073265", "type": "external" } ], "gene_names_uniprotkb": "SNRPN", "gene_names_refseq": "SNRPN", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein-associated protein N; Sm protein N; Sm-N; SmN; snRNP-N", "protein_names_refseq": "sm protein N; sm-N; smN; small nuclear ribonucleoprotein-associated protein N; snRNP-N", "tax_id": 9913, "disease": "", "pathway": " (bta:780877); (R-BTA-72163); (R-BTA-9770562); (R-BTA-9943411)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "16790688;19200381", "class_list": "", "function": "May be involved in tissue-specific alternative RNA processing events., [UniProtKB]; Results suggest that artificial reproductive techniques, such as prolonged in vitro culture and SCNT, lead to abnormal reprogramming of imprinting of SNRPN gene by altering methylation levels at this locus. Publication Status: Online-Only, [RefSeq, PubMed]; SNRPN methylation profiles previously observed in mouse and human studies are also conserved in cattle, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6QL65", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0070990 snRNP binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0005687 U4 snRNP", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q17QN3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29448-1", "uniprot_id": [ { "id": "HMGCL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29448", "type": "external" } ], "mass": 34168.0, "length": 325, "protein_name": "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "gene_name": "HMGCL", "organism": "Bovine", "refseq_name": "hydroxymethylglutaryl-CoA lyase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001068600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068600", "type": "external" } ], "gene_names_uniprotkb": "HMGCL", "gene_names_refseq": "HMGCL", "protein_names_uniprotkb": "Hydroxymethylglutaryl-CoA lyase, mitochondrial; 3-hydroxy-3-methylglutarate-CoA lyase; 4.1.3.4; HL; HMG-CoA lyase", "protein_names_refseq": "3-hydroxy-3-methylglutarate-CoA lyase; 3-hydroxymethyl-3-methylglutaryl-CoA lyase; 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase; HL; HMG-CoA lyase; hydroxymethylglutaricaciduria; hydroxymethylglutaryl-CoA lyase, mitochondrial precursor; hydroxymethylglutaryl-CoA lyase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:317658); (R-BTA-77111); (R-BTA-9033241)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q148J2", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0046872 metal ion binding;GO:0005198 structural molecule activity;GO:0004419 hydroxymethylglutaryl-CoA lyase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046951 ketone body biosynthetic process;GO:0006552 L-leucine catabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29448-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VD48-1", "uniprot_id": [ { "id": "VPS4B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VD48", "type": "external" } ], "mass": 49264.0, "length": 444, "protein_name": "Vacuolar protein sorting-associated protein 4B", "gene_name": "VPS4B", "organism": "Bovine", "refseq_name": "vacuolar protein sorting-associated protein 4B", "refseq_ac": [ { "id": "NP_001069624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069624", "type": "external" } ], "gene_names_uniprotkb": "VPS4B", "gene_names_refseq": "VPS4B", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 4B; 3.6.4.6", "protein_names_refseq": "vacuolar protein sorting-associated protein 4B", "tax_id": 9913, "disease": "", "pathway": " (bta:539357); (R-BTA-917729)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "(Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (lentiviruses)., [UniProtKB, UniProtKB]; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Involved in cytokinesis. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005813 centrosome", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex;GO:1904903 ESCRT III complex disassembly;GO:0061738 late endosomal microautophagy;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VD48-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VD18-1", "uniprot_id": [ { "id": "LHPP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VD18", "type": "external" } ], "mass": 29180.0, "length": 270, "protein_name": "Phospholysine phosphohistidine inorganic pyrophosphate phosphatase", "gene_name": "LHPP", "organism": "Bovine", "refseq_name": "phospholysine phosphohistidine inorganic pyrophosphate phosphatase", "refseq_ac": [ { "id": "NP_001074381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074381", "type": "external" } ], "gene_names_uniprotkb": "LHPP", "gene_names_refseq": "LHPP", "protein_names_uniprotkb": "Phospholysine phosphohistidine inorganic pyrophosphate phosphatase; 3.1.3.-; 3.6.1.1", "protein_names_refseq": "phospholysine phosphohistidine inorganic pyrophosphate phosphatase", "tax_id": 9913, "disease": "", "pathway": " (bta:534183); (R-BTA-71737)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12801912;9448729", "class_list": "", "function": "Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004427 inorganic diphosphate phosphatase activity;GO:0016791 phosphatase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006796 phosphate-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VD18-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBZ0-1", "uniprot_id": [ { "id": "CSK_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VBZ0", "type": "external" } ], "mass": 50633.0, "length": 450, "protein_name": "Tyrosine-protein kinase CSK", "gene_name": "CSK", "organism": "Bovine", "refseq_name": "tyrosine-protein kinase CSK", "refseq_ac": [ { "id": "NP_001068865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068865", "type": "external" } ], "gene_names_uniprotkb": "CSK", "gene_names_refseq": "CSK", "protein_names_uniprotkb": "Tyrosine-protein kinase CSK; 2.7.10.4; C-Src kinase", "protein_names_refseq": "C-SRC kinase; CSK, non-receptor tyrosine kinase; c-src tyrosine kinase; tyrosine-protein kinase CSK", "tax_id": 9913, "disease": "", "pathway": " (bta:509246); (R-BTA-180292); (R-BTA-202427); (R-BTA-354192); (R-BTA-389948); (R-BTA-5674135); (R-BTA-9013407); (R-BTA-9706369)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "15855164;18621907;19359662", "class_list": "", "function": "Dok-4 has a role as an anchoring molecule for the tyrosine kinase c-Src, and in turn as a regulator of TNF-alpha-mediated ROS production and NF-kappaB activation, [RefSeq, PubMed]; Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells., [RefSeq, PubMed]; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity). May act as a negative regulator of EGFR and STAT3 signaling pathways (By similarity)., [UniProtKB, UniProtKB]; Src family tyrosine kinases play a central role of arginase and inducible nitric oxide synthase in pulmonary artery endothelium., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway;GO:0035556 intracellular signal transduction;GO:0002250 adaptive immune response;GO:0034332 adherens junction organization;GO:0042997 negative regulation of Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0VBZ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ60-1", "uniprot_id": [ { "id": "ROA2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ60", "type": "external" } ], "mass": 36006.0, "length": 341, "protein_name": "Heterogeneous nuclear ribonucleoproteins A2/B1", "gene_name": "HNRNPA2B1", "organism": "Bovine", "refseq_name": "heterogeneous nuclear ribonucleoproteins A2/B1", "refseq_ac": [ { "id": "NP_001421690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421690", "type": "external" } ], "gene_names_uniprotkb": "HNRNPA2B1; HNRPA2B1", "gene_names_refseq": "HNRNPA2B1; HNRPA2B1", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1", "protein_names_refseq": "heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1; hnRNP A2/B1", "tax_id": 9913, "disease": "", "pathway": " (bta:507564); (R-BTA-72163); (R-BTA-72203); (R-BTA-9770562)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (By similarity). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (By similarity). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035198 miRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0043047 single-stranded telomeric DNA binding;GO:1990247 N6-methyladenosine-containing RNA reader activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070062 extracellular exosome;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0000398 mRNA splicing, via spliceosome;GO:1990428 miRNA transport;GO:0051028 mRNA transport;GO:0031053 primary miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ60-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCL6-1", "uniprot_id": [ { "id": "NFIB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCL6", "type": "external" } ], "mass": 47499.0, "length": 420, "protein_name": "Nuclear factor 1 B-type", "gene_name": "NFIB", "organism": "Bovine", "refseq_name": "nuclear factor 1 B-type", "refseq_ac": [ { "id": "NP_001069572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069572", "type": "external" } ], "gene_names_uniprotkb": "NFIB", "gene_names_refseq": "NFIB", "protein_names_uniprotkb": "Nuclear factor 1 B-type; NF-I/B; NF1-B; NFI-B; Nuclear factor 1/B; Nuclear factor I/B", "protein_names_refseq": "NF-I/B; NF1-B; NFI-B; nuclear factor 1 B-type; nuclear factor 1/B", "tax_id": 9913, "disease": "", "pathway": " (bta:538474)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0044300 cerebellar mossy fiber;GO:0005654 nucleoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006260 DNA replication;GO:0002062 chondrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCL6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZ74-1", "uniprot_id": [ { "id": "OARD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZ74", "type": "external" } ], "mass": 17035.0, "length": 152, "protein_name": "ADP-ribose glycohydrolase OARD1", "gene_name": "OARD1", "organism": "Bovine", "refseq_name": "ADP-ribose glycohydrolase OARD1", "refseq_ac": [ { "id": "NP_001070581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070581", "type": "external" } ], "gene_names_uniprotkb": "OARD1", "gene_names_refseq": "C23H6orf130; C6orf130; OARD1", "protein_names_uniprotkb": "ADP-ribose glycohydrolase OARD1; 3.2.2.-; 3.5.1.-; O-acetyl-ADP-ribose deacetylase 1; Terminal ADP-ribose protein glycohydrolase 1; [Protein ADP-ribosylglutamate] hydrolase OARD1", "protein_names_refseq": "ADP-ribose glycohydrolase OARD1; O-acetyl-ADP-ribose deacetylase 1; O-acetyl-ADP-ribose deacetylase C6orf130 homolog; [Protein ADP-ribosylglutamate] hydrolase OARD1; terminal ADP-ribose protein glycohydrolase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:768056)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.1.1.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.106", "type": "external" }, { "id": "3.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.19", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" } ], "go_molecular_function": "GO:0001883 purine nucleoside binding;GO:0061463 O-acetyl-ADP-ribose deacetylase activity;GO:0140293 ADP-ribosylglutamate hydrolase activity;GO:0047407 ADP-ribosyl-[dinitrogen reductase] hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006974 DNA damage response;GO:0051725 protein de-ADP-ribosylation;GO:0042278 purine nucleoside metabolic process;GO:0140291 peptidyl-glutamate ADP-deribosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1LZ74-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07130-1", "uniprot_id": [ { "id": "UGPA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q07130", "type": "external" } ], "mass": 56903.0, "length": 508, "protein_name": "UTP--glucose-1-phosphate uridylyltransferase", "gene_name": "UGP2", "organism": "Bovine", "refseq_name": "UTP--glucose-1-phosphate uridylyltransferase", "refseq_ac": [ { "id": "NP_776637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776637", "type": "external" } ], "gene_names_uniprotkb": "UGP2", "gene_names_refseq": "UGP2", "protein_names_uniprotkb": "UTP--glucose-1-phosphate uridylyltransferase; 2.7.7.9; UDP-glucose pyrophosphorylase; UDPGP; UGPase", "protein_names_refseq": "UDPGP; UGPase; UTP--glucose-1-phosphate uridylyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:281565); (R-BTA-173599); (R-BTA-3322077)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8407878", "class_list": "", "function": "UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17QU0", "ec_number_list": [ { "id": "2.7.7.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0005978 glycogen biosynthetic process;GO:0006011 UDP-alpha-D-glucose metabolic process;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q07130-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80177-1", "uniprot_id": [ { "id": "MIF_BOVIN", "url": "https://www.uniprot.org/uniprot/P80177", "type": "external" } ], "mass": 12343.0, "length": 115, "protein_name": "Macrophage migration inhibitory factor", "gene_name": "MIF", "organism": "Bovine", "refseq_name": "macrophage migration inhibitory factor", "refseq_ac": [ { "id": "NP_001028780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028780", "type": "external" } ], "gene_names_uniprotkb": "MIF", "gene_names_refseq": "MIF", "protein_names_uniprotkb": "Macrophage migration inhibitory factor; 5.3.2.1; 5.3.3.12; L-dopachrome isomerase; L-dopachrome tautomerase; MIF; Phenylpyruvate tautomerase; p12A", "protein_names_refseq": "L-dopachrome isomerase; L-dopachrome tautomerase; macrophage migration inhibitory factor (glycosylation-inhibiting factor); macrophage migration inhibitory factor; p12A; phenylpyruvate tautomerase", "tax_id": 9913, "disease": "", "pathway": " (bta:280858); (R-BTA-202733); (R-BTA-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10727256;12855605;16457622;21774622;25426961;26853787;27465152;7925355;8458415", "class_list": "", "function": "Data suggest that, in obese cows, expression of MIF is suppressed in the ampulla and isthmus of Fallopian tubes as compared to normal-weight cows; however, MIF expression is also lower in Fallopian tubes of lean cows. The primary site of MIF expression in Fallopian tube ampulla/isthmus is the tunica mucosa. These studies were conducted in Japanese Black calves., [RefSeq, PubMed]; In conclusion, the bovine ampulla and isthmus have higher MIF expression during the postovulatory phase., [RefSeq, PubMed]; MIF plays a role in early embryo development, and further characterization of MIF expression and its regulation in the endometrium will add significantly to our understanding of early embryo-uterine interactions, [RefSeq, PubMed]; Plasma MIF concentrations may increase with age in months and parity, but do not change either before and after parturition or before and after postpartum first ovulation in Japanese black cows, [RefSeq, PubMed]; Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The objective of the present study was to determine if SNPs in 5' region of bovine MIF affects its promoter activity., [RefSeq, PubMed]; The purification of macrophage migration inhibitory factor (MIF) from bovine brain cytosol and its partial characterization are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T190;Q9XT46", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0005125 cytokine activity;GO:0004167 dopachrome isomerase activity;GO:0050178 phenylpyruvate tautomerase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0080135 regulation of cellular response to stress", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P80177-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55803-1", "uniprot_id": [ { "id": "MOG_BOVIN", "url": "https://www.uniprot.org/uniprot/P55803", "type": "external" } ], "mass": 28028.0, "length": 246, "protein_name": "Myelin-oligodendrocyte glycoprotein", "gene_name": "MOG; ZFP57", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MOG; ZFP57; MOG", "gene_names_refseq": "", "protein_names_uniprotkb": "Myelin-oligodendrocyte glycoprotein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:786262)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8367453;8371836", "class_list": "", "function": "Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication., [UniProtKB]; Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5PKD0", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane;GO:0005634 nucleus", "go_biological_process": "GO:0007155 cell adhesion;GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production;GO:0006357 regulation of transcription by RNA polymerase II;GO:0141068 autosome genomic imprinting", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P55803-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2NKZ1-1", "uniprot_id": [ { "id": "TCPH_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2NKZ1", "type": "external" } ], "mass": 59443.0, "length": 543, "protein_name": "T-complex protein 1 subunit eta", "gene_name": "CCT7", "organism": "Bovine", "refseq_name": "T-complex protein 1 subunit eta", "refseq_ac": [ { "id": "NP_001039636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039636", "type": "external" } ], "gene_names_uniprotkb": "CCT7", "gene_names_refseq": "CCT-ETA; CCT7; TCP-1-ETA", "protein_names_uniprotkb": "T-complex protein 1 subunit eta; 3.6.1.-; CCT-eta; TCP-1-eta", "protein_names_refseq": "HIV-1 Nef interacting protein; T-complex protein 1 subunit eta; chaperonin containing TCP1, subunit 7 (eta)", "tax_id": 9913, "disease": "", "pathway": " (bta:514355); (R-BTA-390471); (R-BTA-6814122); (R-BTA-9013418); (R-BTA-9013422)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein., [UniProtKB, UniProtKB]; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005874 microtubule;GO:0044297 cell body;GO:0005832 chaperonin-containing T-complex", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2NKZ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMU3-1", "uniprot_id": [ { "id": "P4HA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMU3", "type": "external" } ], "mass": 61010.0, "length": 534, "protein_name": "Prolyl 4-hydroxylase subunit alpha-1", "gene_name": "P4HA1", "organism": "Bovine", "refseq_name": "prolyl 4-hydroxylase subunit alpha-1 precursor", "refseq_ac": [ { "id": "NP_001069238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069238", "type": "external" } ], "gene_names_uniprotkb": "P4HA1", "gene_names_refseq": "P4HA1", "protein_names_uniprotkb": "Prolyl 4-hydroxylase subunit alpha-1; 1.14.11.2; 4-PH alpha-1; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1", "protein_names_refseq": "4-PH alpha-1; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1; prolyl 4-hydroxylase subunit alpha-1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:518288)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.2", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0031418 L-ascorbic acid binding;GO:0004656 procollagen-proline 4-dioxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMU3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCY7-1", "uniprot_id": [ { "id": "SRSF1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCY7", "type": "external" } ], "mass": 27745.0, "length": 248, "protein_name": "Serine/arginine-rich splicing factor 1", "gene_name": "SRSF1", "organism": "Bovine", "refseq_name": "serine/arginine-rich splicing factor 1", "refseq_ac": [ { "id": "NP_001069862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069862", "type": "external" } ], "gene_names_uniprotkb": "SRSF1; SFRS1", "gene_names_refseq": "SFRS1; SRSF1", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 1; Splicing factor, arginine/serine-rich 1", "protein_names_refseq": "serine/arginine-rich splicing factor 1; splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor); splicing factor, arginine/serine-rich 1B", "tax_id": 9913, "disease": "", "pathway": " (bta:615796); (R-BTA-159236); (R-BTA-72163); (R-BTA-72165); (R-BTA-72203); (R-BTA-9770562)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0044547 DNA topoisomerase binding;GO:0050733 RS domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0043484 regulation of RNA splicing;GO:0051028 mRNA transport;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition;GO:0048255 mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCY7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ51-1", "uniprot_id": [ { "id": "ANGL4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ51", "type": "external" } ], "mass": 45553.0, "length": 410, "protein_name": "Angiopoietin-related protein 4", "gene_name": "ANGPTL4", "organism": "Bovine", "refseq_name": "angiopoietin-related protein 4 precursor", "refseq_ac": [ { "id": "NP_001039508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039508", "type": "external" } ], "gene_names_uniprotkb": "ANGPTL4", "gene_names_refseq": "ANGPTL4", "protein_names_uniprotkb": "Angiopoietin-related protein 4; Angiopoietin-like protein 4", "protein_names_refseq": "angiopoietin-like protein 4; angiopoietin-like secreted glycoprotein 4; angiopoietin-related protein 4 precursor; angiopoietin-related protein 4", "tax_id": 9913, "disease": "", "pathway": " (bta:509963); (R-BTA-8963889); (R-BTA-9762292)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "19783696;22683322", "class_list": "", "function": "Increase in angiopoietin-like protein 4 messenger RNA across multiple models of altered energy balance identifies it as an adipokine that is uniquely responsive to changes in energy balance in the lactating dairy cow, [RefSeq, PubMed]; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein., [UniProtKB, UniProtKB]; These findings indicate that liver and adipose tissue are key sources of ANGPTL4 in cattle; the protein was also highly abundant in ruminal epithelium, making it possible that commensal microbes may influence ANGPTL4 synthesis and secretion., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0042802 identical protein binding;GO:0055102 lipase inhibitor activity;GO:0035473 lipase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0043335 protein unfolding;GO:0001525 angiogenesis;GO:0006629 lipid metabolic process;GO:0043066 negative regulation of apoptotic process;GO:0045717 negative regulation of fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2KJ51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMS5-1", "uniprot_id": [ { "id": "NXF1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMS5", "type": "external" } ], "mass": 70305.0, "length": 620, "protein_name": "Nuclear RNA export factor 1", "gene_name": "NXF1", "organism": "Bovine", "refseq_name": "nuclear RNA export factor 1", "refseq_ac": [ { "id": "NP_001069023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069023", "type": "external" } ], "gene_names_uniprotkb": "NXF1", "gene_names_refseq": "NXF1", "protein_names_uniprotkb": "Nuclear RNA export factor 1", "protein_names_refseq": "nuclear RNA export factor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:512136); (R-BTA-159227); (R-BTA-159230); (R-BTA-159231); (R-BTA-159236)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005643 nuclear pore;GO:0000346 transcription export complex", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMS5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0III2-1", "uniprot_id": [ { "id": "MBTP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0III2", "type": "external" } ], "mass": 57214.0, "length": 516, "protein_name": "Membrane-bound transcription factor site-2 protease", "gene_name": "MBTPS2", "organism": "Bovine", "refseq_name": "membrane-bound transcription factor site-2 protease", "refseq_ac": [ { "id": "NP_001069449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069449", "type": "external" } ], "gene_names_uniprotkb": "MBTPS2", "gene_names_refseq": "MBTPS2", "protein_names_uniprotkb": "Membrane-bound transcription factor site-2 protease; 3.4.24.85; Endopeptidase S2P", "protein_names_refseq": "S2P endopeptidase; endopeptidase S2P; membrane-bound transcription factor site-2 protease; site-2 protease", "tax_id": 9913, "disease": "", "pathway": " (bta:533134); (R-BTA-1655829); (R-BTA-381033); (R-BTA-8874177); (R-BTA-8874211)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.85", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.85", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0140537 transcription regulator activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045542 positive regulation of cholesterol biosynthetic process;GO:0031293 membrane protein intracellular domain proteolysis;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0III2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBY8-1", "uniprot_id": [ { "id": "DDB2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VBY8", "type": "external" } ], "mass": 47591.0, "length": 426, "protein_name": "DNA damage-binding protein 2", "gene_name": "DDB2", "organism": "Bovine", "refseq_name": "DNA damage-binding protein 2", "refseq_ac": [ { "id": "NP_001069256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069256", "type": "external" } ], "gene_names_uniprotkb": "DDB2", "gene_names_refseq": "DDB2", "protein_names_uniprotkb": "DNA damage-binding protein 2; Damage-specific DNA-binding protein 2", "protein_names_refseq": "DNA damage-binding protein 2; damage-specific DNA binding protein 2, 48kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:519357); (R-BTA-5689880); (R-BTA-5696394); (R-BTA-5696395); (R-BTA-5696400); (R-BTA-8951664)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0044877 protein-containing complex binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031465 Cul4B-RING E3 ubiquitin ligase complex;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006281 DNA repair;GO:0009411 response to UV;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination;GO:0070914 UV-damage excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VBY8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54349-1", "uniprot_id": [ { "id": "IL12A_BOVIN", "url": "https://www.uniprot.org/uniprot/P54349", "type": "external" } ], "mass": 24944.0, "length": 221, "protein_name": "Interleukin-12 subunit alpha", "gene_name": "IL12A", "organism": "Bovine", "refseq_name": "interleukin-12 subunit alpha precursor", "refseq_ac": [ { "id": "NP_776780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776780", "type": "external" } ], "gene_names_uniprotkb": "IL12A", "gene_names_refseq": "IL12A; IL12p35; Il-12 p35", "protein_names_uniprotkb": "Interleukin-12 subunit alpha; CLMF p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL-12A", "protein_names_refseq": "CLMF p35; IL-12 subunit p35; IL-12A; cytotoxic lymphocyte maturation factor 35 kDa subunit; interleukin 12 35kDa subunit; interleukin 12 polypeptide 35; interleukin-12 subunit alpha precursor; interleukin-12 subunit alpha; natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35", "tax_id": 9913, "disease": "", "pathway": " (bta:281856); (R-BTA-8984722); (R-BTA-9020591)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "17530193;17727806;7727547", "class_list": "", "function": "Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Lipopolysaccharide stimulation up-regulates the secretion of cytokines, including interleukin-12, by bovine polymorphonuclear neutrophil leukocytes., [RefSeq, PubMed]; The results showed that the expression of TNF-alpha, iNOS, and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6, IL-12], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A9QWR3", "ec_number_list": [], "go_molecular_function": "GO:0005143 interleukin-12 receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0042163 interleukin-12 beta subunit binding;GO:0045513 interleukin-27 binding", "go_cellular_component": "GO:0043514 interleukin-12 complex;GO:0005615 extracellular space", "go_biological_process": "GO:0035722 interleukin-12-mediated signaling pathway;GO:0032729 positive regulation of type II interferon production;GO:0042093 T-helper cell differentiation;GO:0042104 positive regulation of activated T cell proliferation;GO:0030101 natural killer cell activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P54349-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ92-1", "uniprot_id": [ { "id": "LFNG_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ92", "type": "external" } ], "mass": 41847.0, "length": 380, "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe", "gene_name": "LFNG", "organism": "Bovine", "refseq_name": "beta-1,3-N-acetylglucosaminyltransferase lunatic fringe", "refseq_ac": [ { "id": "NP_001039687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039687", "type": "external" } ], "gene_names_uniprotkb": "LFNG", "gene_names_refseq": "LFNG", "protein_names_uniprotkb": "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase", "protein_names_refseq": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe", "tax_id": 9913, "disease": "", "pathway": " (bta:516209)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.222", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.222", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0001756 somitogenesis;GO:0030217 T cell differentiation;GO:0002315 marginal zone B cell differentiation;GO:1902367 negative regulation of Notch signaling pathway involved in somitogenesis;GO:0008593 regulation of Notch signaling pathway", "synthesized_glycan_count": 19, "hit_score": 0.1, "record_id": "Q2KJ92-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KID0-1", "uniprot_id": [ { "id": "EXOS2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KID0", "type": "external" } ], "mass": 32649.0, "length": 293, "protein_name": "Exosome complex component RRP4", "gene_name": "EXOSC2", "organism": "Bovine", "refseq_name": "exosome complex component RRP4", "refseq_ac": [ { "id": "NP_001040026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040026", "type": "external" } ], "gene_names_uniprotkb": "EXOSC2; RRP4", "gene_names_refseq": "EXOSC2", "protein_names_uniprotkb": "Exosome complex component RRP4; Exosome component 2; Ribosomal RNA-processing protein 4", "protein_names_refseq": "exosome complex component RRP4; exosome complex exonuclease RRP4; ribosomal RNA-processing protein 4", "tax_id": 9913, "disease": "", "pathway": " (bta:615712); (R-BTA-429958); (R-BTA-450385); (R-BTA-450513); (R-BTA-450604); (R-BTA-6791226); (R-BTA-9930044)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000176 nuclear exosome (RNase complex);GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0034475 U4 snRNA 3'-end processing;GO:0071034 CUT catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KID0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0NXR6-1", "uniprot_id": [ { "id": "ACAD8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0NXR6", "type": "external" } ], "mass": 45307.0, "length": 416, "protein_name": "Isobutyryl-CoA dehydrogenase, mitochondrial", "gene_name": "ACAD8", "organism": "Bovine", "refseq_name": "isobutyryl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001069019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069019", "type": "external" } ], "gene_names_uniprotkb": "ACAD8", "gene_names_refseq": "ACAD8", "protein_names_uniprotkb": "Isobutyryl-CoA dehydrogenase, mitochondrial; 1.3.8.5; ACAD-8; Acyl-CoA dehydrogenase family member 8", "protein_names_refseq": "ACAD-8; acyl-Coenzyme A dehydrogenase family, member 8; isobutyryl-CoA dehydrogenase, mitochondrial precursor; isobutyryl-CoA dehydrogenase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:512070); (R-BTA-70895); (R-BTA-9837999)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "17498629", "class_list": "", "function": "Isobutyryl-CoA dehydrogenase which catalyzes the conversion of 2-methylpropanoyl-CoA to (2E)-2-methylpropenoyl-CoA in the valine catabolic pathway. To a lesser extent, also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The bovine ACAD8 full-length mRNA and genomic DNA sequence were obtained and its gene structure was determined through alignment of the genomic DNA sequence to the mRNA sequence, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A4N5", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0003853 short-chain 2-methyl fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006574 L-valine catabolic process;GO:0009083 branched-chain amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0NXR6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07175-1", "uniprot_id": [ { "id": "VKGC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q07175", "type": "external" } ], "mass": 87557.0, "length": 758, "protein_name": "Vitamin K-dependent gamma-carboxylase", "gene_name": "GGCX", "organism": "Bovine", "refseq_name": "vitamin K-dependent gamma-carboxylase", "refseq_ac": [ { "id": "NP_776491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776491", "type": "external" } ], "gene_names_uniprotkb": "GGCX; GC", "gene_names_refseq": "GGCX", "protein_names_uniprotkb": "Vitamin K-dependent gamma-carboxylase; 4.1.1.90; Gamma-glutamyl carboxylase; Peptidyl-glutamate 4-carboxylase; Vitamin K gamma glutamyl carboxylase", "protein_names_refseq": "peptidyl-glutamate 4-carboxylase; vitamin K gamma glutamyl carboxylase; vitamin K-dependent gamma-carboxylase", "tax_id": 9913, "disease": "", "pathway": " (bta:281190); (R-BTA-159740)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1749935;8506307", "class_list": "", "function": "Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "3.4.21.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.22", "type": "external" }, { "id": "3.4.21.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6", "type": "external" }, { "id": "3.4.21.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.21", "type": "external" }, { "id": "4.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90", "type": "external" } ], "go_molecular_function": "GO:0019842 vitamin binding;GO:0008488 gamma-glutamyl carboxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0042373 vitamin K metabolic process;GO:1903011 negative regulation of bone development;GO:0046929 negative regulation of neurotransmitter secretion;GO:0051604 protein maturation;GO:2000225 negative regulation of testosterone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q07175-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCR6-1", "uniprot_id": [ { "id": "DIESL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCR6", "type": "external" } ], "mass": 38555.0, "length": 334, "protein_name": "DGAT1/2-independent enzyme synthesizing storage lipids", "gene_name": "TMEM68", "organism": "Bovine", "refseq_name": "DGAT1/2-independent enzyme synthesizing storage lipids", "refseq_ac": [ { "id": "NP_001069477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069477", "type": "external" } ], "gene_names_uniprotkb": "TMEM68", "gene_names_refseq": "DIESL; MGAT/DGAT; TMEM68", "protein_names_uniprotkb": "DGAT1/2-independent enzyme synthesizing storage lipids; 2-acylglycerol/1,2-diacylglycerol O-acyltransferase; 2.3.1.-; 2.3.1.20; 2.3.1.22; DIESL; MGAT/DGAT; Monoacylglycerol/Diacylglycerol O-acyltransferase; Transmembrane protein 68", "protein_names_refseq": "2-acylglycerol/1,2-diacylglycerol O-acyltransferase; DGAT1/2-independent enzyme synthesizing storage lipids; monoacylglycerol/Diacylglycerol O-acyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:534013)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of the alternative triglyceride biosynthesis pathway, which mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids. Synthesizes triacylglycerol at the expense of membrane phospholipids, such as phosphatidylcholine (PC) and its ether-linked form (ePC), thereby altering the composition of membranes. The alternative triglyceride biosynthesis pathway is probably required to provide the energy required for rapid growth when fuel sources are limiting. It maintains mitochondrial function during periods of extracellular lipid starvation (By similarity). Can also use acyl-CoA as donor: acts as a acyl-CoA:monoacylglycerol acyltransferase (MGAT), but also shows acyl-CoA:diacylglycerol acyltransferase (DGAT) activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.22", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity;GO:0046027 phospholipid:diacylglycerol acyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCR6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ95-1", "uniprot_id": [ { "id": "ZDHC6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ95", "type": "external" } ], "mass": 47531.0, "length": 413, "protein_name": "Palmitoyltransferase ZDHHC6", "gene_name": "ZDHHC6", "organism": "Bovine", "refseq_name": "palmitoyltransferase ZDHHC6", "refseq_ac": [ { "id": "NP_001039632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039632", "type": "external" } ], "gene_names_uniprotkb": "ZDHHC6", "gene_names_refseq": "ZDHHC6", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC6; 2.3.1.-; 2.3.1.225; DHHC-6; Stearoyltransferase ZDHHC6; Zinc finger DHHC domain-containing protein 6", "protein_names_refseq": "DHHC-6; palmitoyltransferase ZDHHC6; probable palmitoyltransferase ZDHHC6; stearoyltransferase ZDHHC6; zinc finger DHHC domain-containing protein 6; zinc finger DHHC-type containing 6", "tax_id": 9913, "disease": "", "pathway": " (bta:514158)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (By similarity). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (By similarity). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (By similarity). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (By similarity). Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ95-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMU5-1", "uniprot_id": [ { "id": "RBM5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMU5", "type": "external" } ], "mass": 92269.0, "length": 815, "protein_name": "RNA-binding protein 5", "gene_name": "RBM5", "organism": "Bovine", "refseq_name": "RNA-binding protein 5", "refseq_ac": [ { "id": "NP_001039839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039839", "type": "external" } ], "gene_names_uniprotkb": "RBM5; LUCA15", "gene_names_refseq": "LUCA15; RBM5", "protein_names_uniprotkb": "RNA-binding protein 5; Putative tumor suppressor LUCA15; RNA-binding motif protein 5", "protein_names_refseq": "G15 protein; RNA-binding protein 5; putative tumor suppressor LUCA15; tumor suppressor LUCA15", "tax_id": 9913, "disease": "", "pathway": " (bta:534216); (R-BTA-9770562)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (By similarity). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMU5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E53-1", "uniprot_id": [ { "id": "NR4A2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E53", "type": "external" } ], "mass": 66621.0, "length": 598, "protein_name": "Nuclear receptor subfamily 4 group A member 2", "gene_name": "NR4A2", "organism": "Bovine", "refseq_name": "nuclear receptor subfamily 4 group A member 2", "refseq_ac": [ { "id": "NP_001069676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069676", "type": "external" } ], "gene_names_uniprotkb": "NR4A2", "gene_names_refseq": "NR4A2", "protein_names_uniprotkb": "Nuclear receptor subfamily 4 group A member 2", "protein_names_refseq": "nuclear receptor subfamily 4 group A member 2", "tax_id": 9913, "disease": "", "pathway": " (bta:540245); (R-BTA-383280)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0035259 nuclear glucocorticoid receptor binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045444 fat cell differentiation;GO:0021953 central nervous system neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E53-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJG4-1", "uniprot_id": [ { "id": "MGST2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJG4", "type": "external" } ], "mass": 16483.0, "length": 146, "protein_name": "Microsomal glutathione S-transferase 2", "gene_name": "MGST2", "organism": "Bovine", "refseq_name": "microsomal glutathione S-transferase 2", "refseq_ac": [ { "id": "NP_001069850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069850", "type": "external" } ], "gene_names_uniprotkb": "MGST2", "gene_names_refseq": "MGST2", "protein_names_uniprotkb": "Microsomal glutathione S-transferase 2; 1.11.1.-; 2.5.1.18; 4.4.1.20; Glutathione peroxidase MGST2; Leukotriene C4 synthase MGST2; Microsomal GST-2; Microsomal GST-II; Microsomal glutathione S-transferase II", "protein_names_refseq": "glutathione peroxidase MGST2; leukotriene C4 synthase MGST2; microsomal GST-2; microsomal GST-II; microsomal glutathione S-transferase 2; microsomal glutathione S-transferase II", "tax_id": 9913, "disease": "", "pathway": " (bta:615552); (R-BTA-156590); (R-BTA-5423646)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "4.1.1.84", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.84", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0004464 leukotriene-C4 synthase activity;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0019370 leukotriene biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KJG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9U1-1", "uniprot_id": [ { "id": "SRP54_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9U1", "type": "external" } ], "mass": 55705.0, "length": 504, "protein_name": "Signal recognition particle subunit SRP54", "gene_name": "SRP54", "organism": "Bovine", "refseq_name": "signal recognition particle subunit SRP54", "refseq_ac": [ { "id": "NP_001033290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033290", "type": "external" } ], "gene_names_uniprotkb": "SRP54", "gene_names_refseq": "SRP54", "protein_names_uniprotkb": "Signal recognition particle subunit SRP54; 3.6.5.4; Signal recognition particle 54 kDa protein", "protein_names_refseq": "signal recognition particle 54 kDa protein; signal recognition particle 54kDa; signal recognition particle subunit SRP54", "tax_id": 9913, "disease": "", "pathway": " (bta:614017); (R-BTA-1799339)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" } ], "go_molecular_function": "GO:0030942 endoplasmic reticulum signal peptide binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0043021 ribonucleoprotein complex binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0045047 protein targeting to ER;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0030593 neutrophil chemotaxis;GO:0031017 exocrine pancreas development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2T9U1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48427-1", "uniprot_id": [ { "id": "TBCA_BOVIN", "url": "https://www.uniprot.org/uniprot/P48427", "type": "external" } ], "mass": 12707.0, "length": 108, "protein_name": "Tubulin-specific chaperone A", "gene_name": "TBCA", "organism": "Bovine", "refseq_name": "tubulin-specific chaperone A", "refseq_ac": [ { "id": "NP_786997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786997", "type": "external" } ], "gene_names_uniprotkb": "TBCA", "gene_names_refseq": "TBCA", "protein_names_uniprotkb": "Tubulin-specific chaperone A; CFA; TCP1-chaperonin cofactor A; Tubulin-folding cofactor A", "protein_names_refseq": "CFA; TCP1-chaperonin cofactor A; tubulin cofactor a; tubulin-specific chaperone A", "tax_id": 9913, "disease": "", "pathway": " (bta:327683)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7910827;8756698", "class_list": "", "function": "Tubulin-folding protein; involved in the early step of the tubulin folding pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32KV5", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0005737 cytoplasm", "go_biological_process": "GO:0006457 protein folding;GO:0007021 tubulin complex assembly;GO:0007023 post-chaperonin tubulin folding pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48427-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04467-1", "uniprot_id": [ { "id": "IDHP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q04467", "type": "external" } ], "mass": 50739.0, "length": 452, "protein_name": "Isocitrate dehydrogenase [NADP], mitochondrial", "gene_name": "IDH2", "organism": "Bovine", "refseq_name": "isocitrate dehydrogenase [NADP], mitochondrial precursor", "refseq_ac": [ { "id": "NP_786984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786984", "type": "external" } ], "gene_names_uniprotkb": "IDH2", "gene_names_refseq": "IDH2", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NADP], mitochondrial; 1.1.1.42; ICD-M; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase", "protein_names_refseq": "ICD-M; IDH; IDP; NADP(+)-specific ICDH; isocitrate dehydrogenase (NADP(+)) 2, mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial precursor; isocitrate dehydrogenase [NADP], mitochondrial; oxalosuccinate decarboxylase", "tax_id": 9913, "disease": "", "pathway": " (bta:327669); (R-BTA-2151201); (R-BTA-71403); (R-BTA-9837999); (R-BTA-9854311)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "18672100;28100784;8318002", "class_list": "", "function": "Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex., [UniProtKB, UniProtKB]; The enzyme is highly sensitive to Mg(2+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2+)] in mitochondrial energy metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCD4", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0051287 NAD binding;GO:0004450 isocitrate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process;GO:0006103 2-oxoglutarate metabolic process;GO:0006097 glyoxylate cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q04467-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E08-1", "uniprot_id": [ { "id": "SCN4B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E08", "type": "external" } ], "mass": 25144.0, "length": 228, "protein_name": "Sodium channel regulatory subunit beta-4", "gene_name": "SCN4B", "organism": "Bovine", "refseq_name": "sodium channel regulatory subunit beta-4 precursor", "refseq_ac": [ { "id": "NP_001070380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070380", "type": "external" } ], "gene_names_uniprotkb": "SCN4B", "gene_names_refseq": "SCN4B", "protein_names_uniprotkb": "Sodium channel regulatory subunit beta-4", "protein_names_refseq": "sodium channel regulatory subunit beta-4 precursor; sodium channel regulatory subunit beta-4; sodium channel subunit beta-4; sodium channel, voltage-gated, type IV, beta subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:538100); (R-BTA-5576892)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1. Modulates the activity of SCN2A/Nav1.2., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014704 intercalated disc;GO:0001518 voltage-gated sodium channel complex;GO:0016020 membrane", "go_biological_process": "GO:0019228 neuronal action potential;GO:0086091 regulation of heart rate by cardiac conduction;GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization;GO:0061337 cardiac conduction;GO:0010765 positive regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E08-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIL5-1", "uniprot_id": [ { "id": "SNX10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIL5", "type": "external" } ], "mass": 23522.0, "length": 200, "protein_name": "Sorting nexin-10", "gene_name": "SNX10", "organism": "Bovine", "refseq_name": "sorting nexin-10", "refseq_ac": [ { "id": "NP_001068843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068843", "type": "external" } ], "gene_names_uniprotkb": "SNX10", "gene_names_refseq": "SNX10", "protein_names_uniprotkb": "Sorting nexin-10", "protein_names_refseq": "sorting nexin-10", "tax_id": 9913, "disease": "", "pathway": " (bta:508836)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005545 1-phosphatidylinositol binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0035091 phosphatidylinositol binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome;GO:0031313 extrinsic component of endosome membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0006886 intracellular protein transport;GO:0007032 endosome organization;GO:0060271 cilium assembly;GO:0016050 vesicle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIL5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VD07-1", "uniprot_id": [ { "id": "GPM6A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VD07", "type": "external" } ], "mass": 31210.0, "length": 278, "protein_name": "Neuronal membrane glycoprotein M6-a", "gene_name": "GPM6A", "organism": "Bovine", "refseq_name": "neuronal membrane glycoprotein M6-a", "refseq_ac": [ { "id": "NP_001068777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068777", "type": "external" } ], "gene_names_uniprotkb": "GPM6A", "gene_names_refseq": "GPM6A", "protein_names_uniprotkb": "Neuronal membrane glycoprotein M6-a; M6a", "protein_names_refseq": "M6a; neuronal membrane glycoprotein M6-a", "tax_id": 9913, "disease": "", "pathway": " (bta:507389)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G protein-coupled receptors (GPCRs); may enhance internalization and recycling of mu-type opioid receptor (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043197 dendritic spine;GO:0030175 filopodium;GO:0043005 neuron projection", "go_biological_process": "GO:0003407 neural retina development;GO:0031175 neuron projection development;GO:0048863 stem cell differentiation;GO:0001764 neuron migration;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VD07-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P67810-1", "uniprot_id": [ { "id": "SC11A_BOVIN", "url": "https://www.uniprot.org/uniprot/P67810", "type": "external" } ], "mass": 20625.0, "length": 179, "protein_name": "Signal peptidase complex catalytic subunit SEC11A", "gene_name": "SEC11A", "organism": "Bovine", "refseq_name": "signal peptidase complex catalytic subunit SEC11A", "refseq_ac": [ { "id": "NP_776890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776890", "type": "external" } ], "gene_names_uniprotkb": "SEC11A; SEC11L1; SPC18", "gene_names_refseq": "SEC11A; SPC18", "protein_names_uniprotkb": "Signal peptidase complex catalytic subunit SEC11A; 3.4.21.89; Endopeptidase SP18; Microsomal signal peptidase 18 kDa subunit; SEC11 homolog A; SEC11-like protein 1; SPC18; SPase 18 kDa subunit", "protein_names_refseq": "SEC11-like protein 1; SPase 18 kDa subunit; endopeptidase SP18; microsomal signal peptidase 18 kDa subunit; signal peptidase 18 subunit; signal peptidase complex (18kD); signal peptidase complex catalytic subunit SEC11A", "tax_id": 9913, "disease": "", "pathway": " (bta:282078); (R-BTA-422085); (R-BTA-9768727)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "11531706", "class_list": "", "function": "Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QQV7;O75957;P21378", "ec_number_list": [ { "id": "3.4.21.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.89", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0009003 signal peptidase activity", "go_cellular_component": "GO:0005787 signal peptidase complex;GO:0016020 membrane", "go_biological_process": "GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P67810-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2PC20-1", "uniprot_id": [ { "id": "PPM1K_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2PC20", "type": "external" } ], "mass": 41151.0, "length": 372, "protein_name": "Protein phosphatase Mn(2+)-dependent 1K", "gene_name": "PPM1K", "organism": "Bovine", "refseq_name": "protein phosphatase Mn(2+)-dependent 1K precursor", "refseq_ac": [ { "id": "NP_001039939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039939", "type": "external" } ], "gene_names_uniprotkb": "PPM1K", "gene_names_refseq": "BCKDH; BDP; PPM1K", "protein_names_uniprotkb": "Protein phosphatase Mn(2+)-dependent 1K; 3.1.3.16; 3.1.3.52; BCKDH; BDP; Branched-chain alpha-ketoacid dehydrogenase phosphatase; PP2C-kappa; Protein phosphatase 2C family member; Protein phosphatase 2C isoform kappa; [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase", "protein_names_refseq": "PP2C-kappa; [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase; branched-chain alpha-ketoacid dehydrogenase phosphatase; protein phosphatase 1K (PP2C domain containing); protein phosphatase 1K, mitochondrial; protein phosphatase 2C family member; protein phosphatase Mn(2+)-dependent 1K precursor; protein phosphatase Mn(2+)-dependent 1K", "tax_id": 9913, "disease": "", "pathway": " (bta:540329); (R-BTA-70895)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein phosphatase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with BCKDK, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (By similarity). At high levels of branched-chain ketoacids, dephosphorylates and activates mitochondrial BCKDH complex, a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Tightly associates with the E2 component of BCKDH complex and dephosphorylates BCKDHA on Ser-347 (By similarity). Regulates the reversible phosphorylation of ACLY in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. At fasting state, appears to dephosphorylate ACLY on Ser-455 and inactivate it. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). Recognizes phosphosites having SxS or RxxS motifs and strictly depends on Mn(2+) ions for the phosphatase activity. Regulates Ca(2+)-induced opening of mitochondrial transition pore and apoptotic cell death (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17R15;Q2PC19", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.2.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0047385 [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity;GO:0030145 manganese ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1902531 regulation of intracellular signal transduction;GO:0009083 branched-chain amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2PC20-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58073-1", "uniprot_id": [ { "id": "PTHR_BOVIN", "url": "https://www.uniprot.org/uniprot/P58073", "type": "external" } ], "mass": 20408.0, "length": 177, "protein_name": "Parathyroid hormone-related protein", "gene_name": "PTHLH", "organism": "Bovine", "refseq_name": "parathyroid hormone-related protein precursor", "refseq_ac": [ { "id": "NP_777178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777178", "type": "external" } ], "gene_names_uniprotkb": "PTHLH", "gene_names_refseq": "PTHLH; PTHrP", "protein_names_uniprotkb": "Parathyroid hormone-related protein; PTH-rP; PTHrP", "protein_names_refseq": "PTH-rP; parathyroid hormone-related protein precursor; parathyroid hormone-related protein", "tax_id": 9913, "disease": "", "pathway": " (bta:286767); (R-BTA-373080); (R-BTA-418555)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16891784;9584841", "class_list": "", "function": "Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Potent inhibitor of osteoclastic bone resorption., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; To investigate the roles of mammary PTHrP in calcium uptake and/or release in the mammary gland of cows, plasma PTHrP and Ca levels, and their arterial-venous differences were examined in a Jersey cow during the periparturient period., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QPN9;Q8HYS1", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005615 extracellular space;GO:0005654 nucleoplasm", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0002076 osteoblast development;GO:0032330 regulation of chondrocyte differentiation;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P58073-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC71-1", "uniprot_id": [ { "id": "TTLL1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC71", "type": "external" } ], "mass": 49030.0, "length": 423, "protein_name": "Polyglutamylase complex subunit TTLL1", "gene_name": "TTLL1", "organism": "Bovine", "refseq_name": "polyglutamylase complex subunit TTLL1", "refseq_ac": [ { "id": "NP_001069639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069639", "type": "external" } ], "gene_names_uniprotkb": "TTLL1", "gene_names_refseq": "TTLL1", "protein_names_uniprotkb": "Polyglutamylase complex subunit TTLL1; 6.3.2.-; PGs3; Tubulin polyglutamylase TTLL1; Tubulin polyglutamylase complex subunit 3; Tubulin--tyrosine ligase-like protein 1", "protein_names_refseq": "PGs3; polyglutamylase complex subunit TTLL1; probable tubulin polyglutamylase TTLL1; tubulin polyglutamylase complex subunit 3; tubulin tyrosine ligase like 1; tubulin tyrosine ligase-like family, member 1; tubulin--tyrosine ligase-like protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:539530)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step. Modifies both alpha- and beta-tubulins with a preference for the alpha-tail. Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity. Part of the neuronal tubulin polyglutamylase complex. Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. Involved in respiratory motile cilia function through the regulation of beating asymmetry. Essential for sperm flagella biogenesis, motility and male fertility. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0106438 protein-glutamic acid ligase activity, elongating", "go_cellular_component": "GO:0005874 microtubule;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007288 sperm axoneme assembly;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC71-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79251-1", "uniprot_id": [ { "id": "VATG1_BOVIN", "url": "https://www.uniprot.org/uniprot/P79251", "type": "external" } ], "mass": 13682.0, "length": 118, "protein_name": "V-type proton ATPase subunit G 1", "gene_name": "ATP6V1G1", "organism": "Bovine", "refseq_name": "V-type proton ATPase subunit G 1", "refseq_ac": [ { "id": "NP_776670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776670", "type": "external" } ], "gene_names_uniprotkb": "ATP6V1G1; ATP6G1; ATP6G", "gene_names_refseq": "ATP6J; ATP6V1G1", "protein_names_uniprotkb": "V-type proton ATPase subunit G 1; V-ATPase 13 kDa subunit 1; V-ATPase subunit G 1; Vacuolar proton pump subunit G 1; Vacuolar proton pump subunit M16", "protein_names_refseq": "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member J; V-ATPase 13 kDa subunit 1; V-ATPase subunit G 1; V-type proton ATPase subunit G 1; vacuolar H+ ATPase G1; vacuolar proton pump subunit G 1; vacuolar proton pump subunit M16", "tax_id": 9913, "disease": "", "pathway": " (bta:281641); (R-BTA-1222556); (R-BTA-77387); (R-BTA-917977); (R-BTA-9639288); (R-BTA-983712)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "8786335;9099722", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32KN3", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0036295 cellular response to increased oxygen levels;GO:0097401 synaptic vesicle lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P79251-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCN0-1", "uniprot_id": [ { "id": "CLD18_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCN0", "type": "external" } ], "mass": 28033.0, "length": 261, "protein_name": "Claudin-18", "gene_name": "CLDN18", "organism": "Bovine", "refseq_name": "claudin-18", "refseq_ac": [ { "id": "NP_001068984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068984", "type": "external" } ], "gene_names_uniprotkb": "CLDN18", "gene_names_refseq": "CLDN18", "protein_names_uniprotkb": "Claudin-18", "protein_names_refseq": "claudin-18", "tax_id": 9913, "disease": "", "pathway": " (bta:511460)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (By similarity). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0120192 tight junction assembly;GO:0042045 epithelial fluid transport;GO:0048286 lung alveolus development;GO:1900181 negative regulation of protein localization to nucleus;GO:0035265 organ growth", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCN0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56602-1", "uniprot_id": [ { "id": "PPOX_BOVIN", "url": "https://www.uniprot.org/uniprot/P56602", "type": "external" } ], "mass": 50612.0, "length": 477, "protein_name": "Protoporphyrinogen oxidase", "gene_name": "PPOX", "organism": "Bovine", "refseq_name": "protoporphyrinogen oxidase", "refseq_ac": [ { "id": "NP_001179355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179355", "type": "external" } ], "gene_names_uniprotkb": "PPOX", "gene_names_refseq": "PPOX; PPO", "protein_names_uniprotkb": "Protoporphyrinogen oxidase; 1.3.3.4; PPO", "protein_names_refseq": "protoporphyrinogen oxidase", "tax_id": 9913, "disease": "", "pathway": " (bta:515770); (R-BTA-189451)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19393038;27109346;7607249", "class_list": "", "function": "Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Determined significant differences in the proteomes of freshly ingested down boli corresponding to the presence or absence of active PPO. These results show that in the presence of PPO the forage protein is less amenable to proteolysis and provide the novel information that the protected proteins are putatively chloroplastically located., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1BPX0", "ec_number_list": [ { "id": "1.3.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.4", "type": "external" } ], "go_molecular_function": "GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process;GO:0006784 heme A biosynthetic process;GO:0006785 heme B biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56602-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIM0-1", "uniprot_id": [ { "id": "FUCO_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIM0", "type": "external" } ], "mass": 54089.0, "length": 468, "protein_name": "Tissue alpha-L-fucosidase", "gene_name": "FUCA1", "organism": "Bovine", "refseq_name": "tissue alpha-L-fucosidase precursor", "refseq_ac": [ { "id": "NP_001039500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039500", "type": "external" } ], "gene_names_uniprotkb": "FUCA1", "gene_names_refseq": "FUCA1", "protein_names_uniprotkb": "Tissue alpha-L-fucosidase; 3.2.1.51; Alpha-L-fucosidase 1; Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase 1", "protein_names_refseq": "alpha-L-fucosidase I; alpha-L-fucoside fucohydrolase 1; fucosidase, alpha-L- 1, tissue; tissue alpha-L-fucosidase precursor; tissue alpha-L-fucosidase", "tax_id": 9913, "disease": "", "pathway": " (bta:509522); (R-BTA-6798695); (R-BTA-975578)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004560 alpha-L-fucosidase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0019377 glycolipid catabolic process;GO:0016139 glycoside catabolic process;GO:0006004 fucose metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIM0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ98-1", "uniprot_id": [ { "id": "FAHD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ98", "type": "external" } ], "mass": 24499.0, "length": 221, "protein_name": "Oxaloacetate tautomerase FAHD1, mitochondrial", "gene_name": "FAHD1", "organism": "Bovine", "refseq_name": "oxaloacetate tautomerase FAHD1, mitochondrial", "refseq_ac": [ { "id": "NP_001068868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068868", "type": "external" } ], "gene_names_uniprotkb": "FAHD1", "gene_names_refseq": "FAHD1", "protein_names_uniprotkb": "Oxaloacetate tautomerase FAHD1, mitochondrial; 3.7.1.5; 4.1.1.112; 5.3.2.2; Acylpyruvase FAHD1; Fumarylacetoacetate hydrolase domain-containing protein 1; OAA decarboxylase; Oxaloacetate decarboxylase", "protein_names_refseq": "OAA decarboxylase; acylpyruvase FAHD1, mitochondrial; fumarylacetoacetate hydrolase domain-containing protein 1; oxaloacetate decarboxylase, mitochondrial; oxaloacetate decarboxylase; oxaloacetate tautomerase FAHD1, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:509273); (R-BTA-70268)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate. It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition. Also acts as a weak oxaloacetate decarboxylase (ODx), catalyzing the decarboxylation of oxaloacetate (OAA) to pyruvate and CO(2), and as such is likely a regulatory enzyme in the TCA cycle. Also displays acylpyruvase activity, being able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.2", "type": "external" }, { "id": "3.7.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.7.1.5", "type": "external" }, { "id": "4.1.1.112", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.112", "type": "external" } ], "go_molecular_function": "GO:0008948 oxaloacetate decarboxylase activity;GO:0018773 acetylpyruvate hydrolase activity;GO:0034545 fumarylpyruvate hydrolase activity;GO:0047621 acylpyruvate hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006107 oxaloacetate metabolic process;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ98-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83107-1", "uniprot_id": [ { "id": "SOLD1_BOVIN", "url": "https://www.uniprot.org/uniprot/P83107", "type": "external" } ], "mass": 10951.0, "length": 100, "protein_name": "Secreted protein of Ly-6 domain 1", "gene_name": "SOLD1; SSLP1", "organism": "Bovine", "refseq_name": "secreted protein of Ly-6 domain 1 precursor", "refseq_ac": [ { "id": "NP_001098948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098948", "type": "external" } ], "gene_names_uniprotkb": "SOLD1; SSLP1; BOP1", "gene_names_refseq": "SOLD1; SSLP-1; SSLP1", "protein_names_uniprotkb": "Secreted protein of Ly-6 domain 1; Protein BOP1", "protein_names_refseq": "protein BOP-1; secreted protein of Ly-6 domain 1 precursor; secreted protein of Ly-6 domain 1", "tax_id": 9913, "disease": "", "pathway": " (bta:100125878)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11282978;11840564;17488528;19503832;23759217;24950590;33140328", "class_list": "", "function": "Binds specifically to type I collagen., [UniProtKB, PubMed]; Data suggest SOLD1 is expressed in trophoblasts; however, expression is below that in fetal membranes. Anti-bovine SOLD1 antibody has dose-dependent suppressive effect on trophoblast invasiveness; SOLD1 may play role in implantation/placentation. Publication Status: Online-Only, [RefSeq, PubMed]; Fetal trophoblastic and endometrial cells are involved in the secretion of SOLD1. These results suggest that SOLD1 may play a crucial role not only in the remodeling of the uteroplacental area, but also in that of the endometrium during late gestation., [RefSeq, PubMed]; Secreted protein of Ly6 domain 1 enhanced bovine trophoblastic cell migration activity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6QQ03;B5AFL1;C4T8T2", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P83107-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28067-1", "uniprot_id": [ { "id": "KCMB1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28067", "type": "external" } ], "mass": 21957.0, "length": 191, "protein_name": "Calcium-activated potassium channel subunit beta-1", "gene_name": "KCNMB1", "organism": "Bovine", "refseq_name": "calcium-activated potassium channel subunit beta-1", "refseq_ac": [ { "id": "NP_001001141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001141", "type": "external" } ], "gene_names_uniprotkb": "KCNMB1", "gene_names_refseq": "KCNMB1", "protein_names_uniprotkb": "Calcium-activated potassium channel subunit beta-1; BK channel subunit beta-1; BKbeta1; BKbeta; Calcium-activated potassium channel subunit beta; Calcium-activated potassium channel, subfamily M subunit beta-1; Charybdotoxin receptor subunit beta-1; K(VCA)beta-1; Maxi K channel subunit beta-1; Slo-beta-1; Slo-beta", "protein_names_refseq": "BK channel subunit beta-1; BKbeta1; BKbeta; calcium activated potassium channel beta subunit; calcium-activated potassium channel subunit beta-1; calcium-activated potassium channel subunit beta; calcium-activated potassium channel, subfamily M subunit beta-1; charybdotoxin receptor subunit beta-1; k(VCA)beta-1; maxi K channel subunit beta-1; potassium large conductance calcium-activated channel, subfamily M, beta member 1; slo-beta-1; slo-beta", "tax_id": 9913, "disease": "", "pathway": " (bta:407176); (R-BTA-1296052)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8006036", "class_list": "", "function": "Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6QLJ1", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0015269 calcium-activated potassium channel activity", "go_cellular_component": "GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0005513 detection of calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28067-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJA1-1", "uniprot_id": [ { "id": "SH3G1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJA1", "type": "external" } ], "mass": 41455.0, "length": 368, "protein_name": "Endophilin-A2", "gene_name": "SH3GL1", "organism": "Bovine", "refseq_name": "endophilin-A2", "refseq_ac": [ { "id": "NP_001039595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039595", "type": "external" } ], "gene_names_uniprotkb": "SH3GL1", "gene_names_refseq": "SH3GL1", "protein_names_uniprotkb": "Endophilin-A2; Endophilin-2; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1", "protein_names_refseq": "SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1; SH3-domain GRB2-like 1; endophilin-2; endophilin-A2", "tax_id": 9913, "disease": "", "pathway": " (bta:512719); (R-BTA-182971); (R-BTA-6807004); (R-BTA-8856825); (R-BTA-8856828)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "16305752;30573663", "class_list": "", "function": "Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles (By similarity). May recruit other proteins to membranes with high curvature (By similarity)., [UniProtKB, UniProtKB]; Implicated in endocytosis. May recruit other proteins to membranes with high curvature., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1JPK1", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0008289 lipid binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0016020 membrane;GO:0002102 podosome;GO:0031901 early endosome membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0061024 membrane organization;GO:0048488 synaptic vesicle endocytosis;GO:0072319 vesicle uncoating", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2KJA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCZ0-1", "uniprot_id": [ { "id": "NSG2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCZ0", "type": "external" } ], "mass": 19028.0, "length": 171, "protein_name": "Neuronal vesicle trafficking-associated protein 2", "gene_name": "NSG2", "organism": "Bovine", "refseq_name": "neuronal vesicle trafficking-associated protein 2", "refseq_ac": [ { "id": "NP_001069764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069764", "type": "external" } ], "gene_names_uniprotkb": "NSG2", "gene_names_refseq": "HMP19; NSG2", "protein_names_uniprotkb": "Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2", "protein_names_refseq": "neuron-specific protein family member 2; neuronal vesicle trafficking-associated protein 2; protein p19", "tax_id": 9913, "disease": "", "pathway": " (bta:613901)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032051 clathrin light chain binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0016197 endosomal transport;GO:0048268 clathrin coat assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCZ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VD32-1", "uniprot_id": [ { "id": "CRBL2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VD32", "type": "external" } ], "mass": 13787.0, "length": 120, "protein_name": "cAMP-responsive element-binding protein-like 2", "gene_name": "CREBL2", "organism": "Bovine", "refseq_name": "cAMP-responsive element-binding protein-like 2", "refseq_ac": [ { "id": "NP_001069556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069556", "type": "external" } ], "gene_names_uniprotkb": "CREBL2", "gene_names_refseq": "CREBL2", "protein_names_uniprotkb": "cAMP-responsive element-binding protein-like 2", "protein_names_refseq": "cAMP-responsive element-binding protein-like 2", "tax_id": 9913, "disease": "", "pathway": " (bta:537195)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16352405", "class_list": "", "function": "Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0045600 positive regulation of fat cell differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VD32-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMV9-1", "uniprot_id": [ { "id": "CNEP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMV9", "type": "external" } ], "mass": 28393.0, "length": 244, "protein_name": "CTD nuclear envelope phosphatase 1", "gene_name": "CTDNEP1", "organism": "Bovine", "refseq_name": "CTD nuclear envelope phosphatase 1", "refseq_ac": [ { "id": "NP_001039491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039491", "type": "external" } ], "gene_names_uniprotkb": "CTDNEP1; DULLARD", "gene_names_refseq": "CTDNEP1; DULLARD", "protein_names_uniprotkb": "CTD nuclear envelope phosphatase 1; 3.1.3.16; Serine/threonine-protein phosphatase dullard", "protein_names_refseq": "CTD nuclear envelope phosphatase 1; dullard homolog; serine/threonine-protein phosphatase dullard", "tax_id": 9913, "disease": "", "pathway": " (bta:509192); (R-BTA-4419969)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0071595 Nem1-Spo7 phosphatase complex", "go_biological_process": "GO:0034504 protein localization to nucleus;GO:0006998 nuclear envelope organization;GO:0010867 positive regulation of triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMV9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJB8-1", "uniprot_id": [ { "id": "TBA8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJB8", "type": "external" } ], "mass": 50054.0, "length": 449, "protein_name": "Tubulin alpha-8 chain", "gene_name": "TUBA8", "organism": "Bovine", "refseq_name": "tubulin alpha-8 chain", "refseq_ac": [ { "id": "NP_001070563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070563", "type": "external" } ], "gene_names_uniprotkb": "TUBA8", "gene_names_refseq": "TUBA8", "protein_names_uniprotkb": "Tubulin alpha-8 chain; 3.6.5.-; Alpha-tubulin 8", "protein_names_refseq": "alpha-tubulin 8; tubulin alpha-8 chain", "tax_id": 9913, "disease": "", "pathway": " (bta:768036); (R-BTA-2132295); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-3371497); (R-BTA-6807878); (R-BTA-6811436); (R-BTA-9646399); (R-BTA-9648025)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "2207090;6504138;7704569", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2HJB8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79126-1", "uniprot_id": [ { "id": "PPM1G_BOVIN", "url": "https://www.uniprot.org/uniprot/P79126", "type": "external" } ], "mass": 58607.0, "length": 543, "protein_name": "Protein phosphatase 1G", "gene_name": "PPM1G", "organism": "Bovine", "refseq_name": "protein phosphatase 1G", "refseq_ac": [ { "id": "NP_777226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777226", "type": "external" } ], "gene_names_uniprotkb": "PPM1G; PPM1C", "gene_names_refseq": "PPM1G", "protein_names_uniprotkb": "Protein phosphatase 1G; 3.1.3.16; MCPP; Magnesium-dependent calcium inhibitable phosphatase; PP2C-gamma; Protein phosphatase 1B; Protein phosphatase 2C isoform gamma; Protein phosphatase magnesium-dependent 1 gamma", "protein_names_refseq": "MCPP; PP2C-gamma; magnesium-dependent calcium inhibitable phosphatase; protein phosphatase 1B; protein phosphatase 1G; protein phosphatase magnesium-dependent 1 gamma", "tax_id": 9913, "disease": "", "pathway": " (bta:286880)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBB4", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P79126-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ97-1", "uniprot_id": [ { "id": "NCDN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ97", "type": "external" } ], "mass": 78799.0, "length": 729, "protein_name": "Neurochondrin", "gene_name": "NCDN", "organism": "Bovine", "refseq_name": "neurochondrin", "refseq_ac": [ { "id": "NP_001039396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039396", "type": "external" } ], "gene_names_uniprotkb": "NCDN", "gene_names_refseq": "NCDN", "protein_names_uniprotkb": "Neurochondrin", "protein_names_refseq": "neurochondrin", "tax_id": 9913, "disease": "", "pathway": " (bta:505994)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A1L535", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0098794 postsynapse;GO:0010008 endosome membrane", "go_biological_process": "GO:0031175 neuron projection development;GO:0048168 regulation of neuronal synaptic plasticity;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KJ97-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5L5-1", "uniprot_id": [ { "id": "SUMF1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5L5", "type": "external" } ], "mass": 40342.0, "length": 374, "protein_name": "Formylglycine-generating enzyme", "gene_name": "SUMF1", "organism": "Bovine", "refseq_name": "formylglycine-generating enzyme precursor", "refseq_ac": [ { "id": "NP_001069544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069544", "type": "external" } ], "gene_names_uniprotkb": "SUMF1", "gene_names_refseq": "FGE; SUMF1", "protein_names_uniprotkb": "Formylglycine-generating enzyme; 1.8.3.7; C-alpha-formylglycine-generating enzyme 1; FGE; Sulfatase-modifying factor 1", "protein_names_refseq": "C-alpha-formylglycine-generating enzyme 1; formylglycine-generating enzyme precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:536435); (R-BTA-1663150); (R-BTA-9840310)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.8.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.7", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:1903135 cupric ion binding;GO:0120147 formylglycine-generating oxidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0018158 protein oxidation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5L5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBQ0-1", "uniprot_id": [ { "id": "TFB1M_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBQ0", "type": "external" } ], "mass": 38883.0, "length": 341, "protein_name": "Mitochondrial dimethyladenosine transferase 1", "gene_name": "TFB1M", "organism": "Bovine", "refseq_name": "mitochondrial dimethyladenosine transferase 1 isoform 2", "refseq_ac": [ { "id": "NP_001070364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070364", "type": "external" } ], "gene_names_uniprotkb": "TFB1M", "gene_names_refseq": "TFB1M", "protein_names_uniprotkb": "Mitochondrial dimethyladenosine transferase 1; 2.1.1.-; Mitochondrial 12S rRNA dimethylase 1; Mitochondrial transcription factor B1; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1; mtTFB1", "protein_names_refseq": "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1; mitochondrial 12S rRNA dimethylase 1; mitochondrial dimethyladenosine transferase 1 isoform 2; mitochondrial dimethyladenosine transferase 1; mitochondrial transcription factor B1; mtTFB1", "tax_id": 9913, "disease": "", "pathway": " (bta:533438)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27128314", "class_list": "", "function": "Lethal haplotype 5 (HH5) is caused by a deletion of 138kbp, spanning position 93,233kb to 93,371kb on chromosome 9 (BTA9), harboring only dimethyl-adenosine transferase 1 (TFB1M). Erratum:[PLoS One. 2016 Jun 9;11(6):e0157618. doi: 10.1371/journal.pone.0157618. PMID: 27280705] Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial methyltransferase which uses S-adenosyl methionine to dimethylate two highly conserved adjacent adenosine residues (A1583 and A1584) within the loop of helix 45 at the 3-prime end of 12S rRNA, thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity;GO:0034246 mitochondrial transcription factor activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005739 mitochondrion", "go_biological_process": "GO:0031167 rRNA methylation;GO:0006391 transcription initiation at mitochondrial promoter;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2TBQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DE8-1", "uniprot_id": [ { "id": "RAB7B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DE8", "type": "external" } ], "mass": 22751.0, "length": 200, "protein_name": "Ras-related protein Rab-7b", "gene_name": "RAB7B", "organism": "Bovine", "refseq_name": "ras-related protein Rab-7b", "refseq_ac": [ { "id": "NP_001071481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071481", "type": "external" } ], "gene_names_uniprotkb": "RAB7B", "gene_names_refseq": "RAB7B", "protein_names_uniprotkb": "Ras-related protein Rab-7b", "protein_names_refseq": "ras-related protein Rab-7b", "tax_id": 9913, "disease": "", "pathway": " (bta:538050); (R-BTA-8854214); (R-BTA-8873719); (R-BTA-8876198)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0003925 G protein activity;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005764 lysosome;GO:0030670 phagocytic vesicle membrane;GO:0005770 late endosome;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0032755 positive regulation of interleukin-6 production;GO:0008333 endosome to lysosome transport;GO:0045654 positive regulation of megakaryocyte differentiation;GO:0090385 phagosome-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DE8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZH1-1", "uniprot_id": [ { "id": "MARC2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZH1", "type": "external" } ], "mass": 37288.0, "length": 336, "protein_name": "Mitochondrial amidoxime reducing component 2", "gene_name": "MTARC2", "organism": "Bovine", "refseq_name": "mitochondrial amidoxime reducing component 2 precursor", "refseq_ac": [ { "id": "NP_001069848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069848", "type": "external" } ], "gene_names_uniprotkb": "MTARC2; MARC2; MOSC2", "gene_names_refseq": "MARC2; MOSC2; MTARC2", "protein_names_uniprotkb": "Mitochondrial amidoxime reducing component 2; 1.7.-.-; MOSC domain-containing protein 2; Moco sulfurase C-terminal domain-containing protein 2; Molybdenum cofactor sulfurase C-terminal domain-containing protein 2; mARC2", "protein_names_refseq": "MOCO sulphurase C-terminal domain containing 2; MOSC domain-containing protein 2, mitochondrial; mitochondrial amidoxime reducing component 2 precursor; moco sulfurase C-terminal domain-containing protein 2; molybdenum cofactor sulfurase C-terminal domain-containing protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:615506); (R-BTA-211945)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" } ], "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0008940 nitrate reductase activity;GO:0030170 pyridoxal phosphate binding;GO:0043546 molybdopterin cofactor binding;GO:0098809 nitrite reductase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome", "go_biological_process": "GO:0006809 nitric oxide biosynthetic process;GO:0042126 nitrate metabolic process;GO:0070458 cellular detoxification of nitrogen compound", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1LZH1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28072-1", "uniprot_id": [ { "id": "CD3D_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28072", "type": "external" } ], "mass": 18931.0, "length": 168, "protein_name": "T-cell surface glycoprotein CD3 delta chain", "gene_name": "CD3D", "organism": "Bovine", "refseq_name": "T-cell surface glycoprotein CD3 delta chain precursor", "refseq_ac": [ { "id": "NP_001029205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029205", "type": "external" } ], "gene_names_uniprotkb": "CD3D", "gene_names_refseq": "CD3D", "protein_names_uniprotkb": "T-cell surface glycoprotein CD3 delta chain; T-cell receptor T3 delta chain", "protein_names_refseq": "CD3d molecule, delta (CD3-TCR complex); T-cell receptor T3 delta chain; T-cell surface glycoprotein CD3 delta chain precursor; T-cell surface glycoprotein CD3 delta chain; antigen CD3D, delta polypeptide (TiT3 complex)", "tax_id": 9913, "disease": "", "pathway": " (bta:281053); (R-BTA-198933); (R-BTA-202424); (R-BTA-202427); (R-BTA-202430); (R-BTA-202433); (R-BTA-389948); (R-BTA-8856825); (R-BTA-8856828)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "1971793", "class_list": "", "function": "Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZH3", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0032395 MHC class II receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0042105 alpha-beta T cell receptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0002250 adaptive immune response;GO:0045059 positive thymic T cell selection;GO:0050852 T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28072-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II71-1", "uniprot_id": [ { "id": "DEGS2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II71", "type": "external" } ], "mass": 37319.0, "length": 323, "protein_name": "Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2", "gene_name": "DEGS2", "organism": "Bovine", "refseq_name": "sphingolipid delta(4)-desaturase/C4-monooxygenase DES2", "refseq_ac": [ { "id": "NP_001069719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069719", "type": "external" } ], "gene_names_uniprotkb": "DEGS2", "gene_names_refseq": "DEGS2", "protein_names_uniprotkb": "Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; 1.14.18.5; 1.14.19.17; Degenerative spermatocyte homolog 2; Sphingolipid 4-desaturase; Sphingolipid C4-monooxygenase", "protein_names_refseq": "degenerative spermatocyte homolog 2, lipid desaturase; sphingolipid 4-desaturase; sphingolipid C4-monooxygenase; sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2", "tax_id": 9913, "disease": "", "pathway": " (bta:540994); (R-BTA-1660661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Bifunctional enzyme which acts both as a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.18.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.5", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0042284 sphingolipid delta-4 desaturase activity;GO:0102772 sphingolipid C4-monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0006667 sphinganine metabolic process;GO:0030148 sphingolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II71-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMX2-1", "uniprot_id": [ { "id": "UB2D2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMX2", "type": "external" } ], "mass": 16735.0, "length": 147, "protein_name": "Ubiquitin-conjugating enzyme E2 D2", "gene_name": "UBE2D2", "organism": "Bovine", "refseq_name": "ubiquitin-conjugating enzyme E2 D2", "refseq_ac": [ { "id": "NP_001039961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039961", "type": "external" } ], "gene_names_uniprotkb": "UBE2D2; UBC4; UBCH4; UBCH5B", "gene_names_refseq": "UBE2D2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 D2; (E3-independent) E2 ubiquitin-conjugating enzyme D2; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme D2; Ubiquitin carrier protein D2; Ubiquitin-protein ligase D2", "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme D2; E2 ubiquitin-conjugating enzyme D2; ubiquitin carrier protein D2; ubiquitin-conjugating enzyme E2 D2; ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); ubiquitin-protein ligase D2", "tax_id": 9913, "disease": "", "pathway": " (bta:541003); (R-BTA-1234176); (R-BTA-5205685); (R-BTA-5357905); (R-BTA-8866652); (R-BTA-8866654); (R-BTA-8951664); (R-BTA-9033241); (R-BTA-937041); (R-BTA-9705462); (R-BTA-983168); (R-BTA-9954709); (R-BTA-9954716)", "pathway_count": 13, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMX2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCT3-1", "uniprot_id": [ { "id": "TE2IP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCT3", "type": "external" } ], "mass": 44221.0, "length": 399, "protein_name": "Telomeric repeat-binding factor 2-interacting protein 1", "gene_name": "TERF2IP", "organism": "Bovine", "refseq_name": "telomeric repeat-binding factor 2-interacting protein 1", "refseq_ac": [ { "id": "NP_001068880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068880", "type": "external" } ], "gene_names_uniprotkb": "TERF2IP; RAP1", "gene_names_refseq": "TERF2IP", "protein_names_uniprotkb": "Telomeric repeat-binding factor 2-interacting protein 1; RAP1 homolog; Repressor/activator protein 1 homolog; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1", "protein_names_refseq": "RAP1 homolog; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; repressor/activator protein 1 homolog; telomeric repeat-binding factor 2-interacting protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:509625); (R-BTA-110330); (R-BTA-110331); (R-BTA-171306); (R-BTA-171319); (R-BTA-174411); (R-BTA-174414); (R-BTA-174417); (R-BTA-174430); (R-BTA-174437); (R-BTA-2559586); (R-BTA-9670095)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "27531745", "class_list": "", "function": "Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression., [UniProtKB, UniProtKB, UniProtKB]; Rap1 activation was dependent on PKA and required Src family kinases and the Rap1 exchanger C3G., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098505 G-rich strand telomeric DNA binding;GO:0042162 telomeric DNA binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070187 shelterin complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0032205 negative regulation of telomere maintenance;GO:0010833 telomere maintenance via telomere lengthening;GO:0006351 DNA-templated transcription;GO:0035556 intracellular signal transduction;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VCT3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DX7-1", "uniprot_id": [ { "id": "SPNS1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DX7", "type": "external" } ], "mass": 56519.0, "length": 528, "protein_name": "Protein spinster homolog 1", "gene_name": "SPNS1", "organism": "Bovine", "refseq_name": "protein spinster homolog 1", "refseq_ac": [ { "id": "NP_001070276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070276", "type": "external" } ], "gene_names_uniprotkb": "SPNS1", "gene_names_refseq": "SPNS1; spinster", "protein_names_uniprotkb": "Protein spinster homolog 1; BSpin1; Spns1", "protein_names_refseq": "BSpin1; protein spinster homolog 1; sphingolipid transporter 1 (putative); spinster homolog 1", "tax_id": 9913, "disease": "", "pathway": " (bta:505997)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol. Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids. Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), can also transport lysophosphatidylglycerol (LPG), but not other anionic lysophospholipids, sphingosine, nor sphingomyelin. Transports lysophospholipids with saturated, monounsaturated, and polyunsaturated fatty acids, such as 1-hexadecanoyl-sn-glycero-3-phosphocholine, 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine, respectively. Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine. Essential player in lysosomal homeostasis. Crucial for cell survival under conditions of nutrient limitation. May be involved in necrotic or autophagic cell death., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051978 lysophospholipid:sodium symporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0051977 lysophospholipid transport;GO:0033700 phospholipid efflux;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08DX7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ89-1", "uniprot_id": [ { "id": "FKB10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ89", "type": "external" } ], "mass": 64484.0, "length": 583, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP10", "gene_name": "FKBP10", "organism": "Bovine", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP10 precursor", "refseq_ac": [ { "id": "NP_001039868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039868", "type": "external" } ], "gene_names_uniprotkb": "FKBP10", "gene_names_refseq": "FKBP-10; FKBP10", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP10; 5.2.1.8; FK506-binding protein 10; FKBP-10; PPIase FKBP10; Rotamase", "protein_names_refseq": "FK506 binding protein 10, 65 kDa; FK506-binding protein 10; PPIase FKBP10; peptidyl-prolyl cis-trans isomerase FKBP10 precursor; peptidyl-prolyl cis-trans isomerase FKBP10; rotamase", "tax_id": 9913, "disease": "", "pathway": " (bta:535310)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "PPIases accelerate the folding of proteins during protein synthesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005528 FK506 binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ89-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIP6-1", "uniprot_id": [ { "id": "OPRK_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIP6", "type": "external" } ], "mass": 42626.0, "length": 380, "protein_name": "Kappa-type opioid receptor", "gene_name": "OPRK1", "organism": "Bovine", "refseq_name": "kappa-type opioid receptor isoform 1", "refseq_ac": [ { "id": "NP_001039945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039945", "type": "external" } ], "gene_names_uniprotkb": "OPRK1", "gene_names_refseq": "OPRK1", "protein_names_uniprotkb": "Kappa-type opioid receptor; K-OR-1; KOR-1", "protein_names_refseq": "K-OR-1; KOR-1; kappa-type opioid receptor isoform 1; kappa-type opioid receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:540519); (R-BTA-375276); (R-BTA-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions (By similarity)., [UniProtKB]; G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0038048 dynorphin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007626 locomotory behavior;GO:0019233 sensory perception of pain;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIP6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMT7-1", "uniprot_id": [ { "id": "RIOK3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMT7", "type": "external" } ], "mass": 58928.0, "length": 519, "protein_name": "Serine/threonine-protein kinase RIO3", "gene_name": "RIOK3", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase RIO3", "refseq_ac": [ { "id": "NP_001069304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069304", "type": "external" } ], "gene_names_uniprotkb": "RIOK3", "gene_names_refseq": "RIOK3", "protein_names_uniprotkb": "Serine/threonine-protein kinase RIO3; 2.7.11.1; RIO kinase 3", "protein_names_refseq": "serine/threonine-protein kinase RIO3", "tax_id": 9913, "disease": "", "pathway": " (bta:522917); (R-BTA-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase involved in a ribosome quality control that takes place when ribosomes have stalled, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit. Acts downstream of RNF10: specifically recognizes and binds RPS2/us5 and RPS3/us3 monoubiquitinated by RNF10, promoting degradation of the 40S ribosomal subunit in a kinase-dependent manner. The RNF10-RIOK3 ribosome quality control takes place in response to ribosome subunit imbalance or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR). Also involved in regulation of type I interferon (IFN)-dependent immune response, possibly by acting as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappa-B signaling pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0070651 nonfunctional rRNA decay;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMT7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68002-1", "uniprot_id": [ { "id": "VDAC2_BOVIN", "url": "https://www.uniprot.org/uniprot/P68002", "type": "external" } ], "mass": 31620.0, "length": 294, "protein_name": "Non-selective voltage-gated ion channel VDAC2", "gene_name": "VDAC2", "organism": "Bovine", "refseq_name": "non-selective voltage-gated ion channel VDAC2", "refseq_ac": [ { "id": "NP_776911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776911", "type": "external" } ], "gene_names_uniprotkb": "VDAC2", "gene_names_refseq": "VDAC2", "protein_names_uniprotkb": "Non-selective voltage-gated ion channel VDAC2; Outer mitochondrial membrane protein porin 2; VDAC-2", "protein_names_refseq": "VDAC-2; non-selective voltage-gated ion channel VDAC2; outer mitochondrial membrane protein porin 2; voltage-dependent anion-selective channel protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282120); (R-BTA-5205685); (R-BTA-5689880)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11311949;14739283;16305752;17647012;18976238;19688190;22794312;28100784", "class_list": "", "function": "Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Confirm the localisation of VDAC2 in the acrosomal region of bovine spermatozoa using immunoelectron microscopy., [RefSeq, PubMed]; ENO1, VDAC2, and UQCRC2 were significantly correlated with individual fertility in bulls., [RefSeq, PubMed]; Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (By similarity). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (By similarity). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (By similarity). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (By similarity). Associates with the translocase of the outer mitochondrial membrane (TOM) complex and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results describe the expression of voltage-dependent anion channel isoforms in rat, bovine, and chicken brain mitochondria, and suggest that the nature of hexokinase binding site is not determined by the expression of a single VDAC isoform. GeneRIF: Multiple spots on 2D gel representing VDAC2 protein forms with different isoelectric points., [RefSeq, PubMed]; The present study is the first work to report the purification and characterization of VDAC2 from a mammalian tissue. Publication Status: Online-Only, [RefSeq, PubMed]; VDAC2 and VDAC3 might have an alternative structural organization and different functions in outer dense fibers than in mitochondria, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5E9A2;Q9MYV7;Q9TT14", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0005524 ATP binding;GO:0015485 cholesterol binding;GO:0031210 phosphatidylcholine binding;GO:0005244 voltage-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane;GO:0046930 pore complex;GO:0097225 sperm midpiece", "go_biological_process": "GO:0006869 lipid transport;GO:0006820 monoatomic anion transport;GO:0097345 mitochondrial outer membrane permeabilization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P68002-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KHU8-1", "uniprot_id": [ { "id": "IF2G_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KHU8", "type": "external" } ], "mass": 51065.0, "length": 472, "protein_name": "Eukaryotic translation initiation factor 2 subunit 3", "gene_name": "EIF2S3", "organism": "Bovine", "refseq_name": "eukaryotic translation initiation factor 2 subunit 3", "refseq_ac": [ { "id": "NP_001039582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039582", "type": "external" } ], "gene_names_uniprotkb": "EIF2S3", "gene_names_refseq": "EIF2S3", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 3; 3.6.5.3; Eukaryotic translation initiation factor 2 subunit gamma; eIF2-gamma", "protein_names_refseq": "eIF-2-gamma; eIF2-gamma; eukaryotic translation initiation factor 2 subunit 3; eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:512350); (R-BTA-156827); (R-BTA-381042); (R-BTA-382556); (R-BTA-72649); (R-BTA-72695); (R-BTA-72702); (R-BTA-72731); (R-BTA-9840373)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D972", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008135 translation factor activity, RNA binding;GO:0003743 translation initiation factor activity;GO:1990856 methionyl-initiator methionine tRNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006413 translational initiation;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KHU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCE9-1", "uniprot_id": [ { "id": "RIMKB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCE9", "type": "external" } ], "mass": 42550.0, "length": 386, "protein_name": "Beta-citrylglutamate synthase B", "gene_name": "RIMKLB", "organism": "Bovine", "refseq_name": "beta-citrylglutamate synthase B", "refseq_ac": [ { "id": "NP_001069581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069581", "type": "external" } ], "gene_names_uniprotkb": "RIMKLB; FAM80B", "gene_names_refseq": "FAM80B; NAAGS; RIMKLB", "protein_names_uniprotkb": "Beta-citrylglutamate synthase B; 6.3.1.17; 6.3.2.41; N-acetyl-aspartylglutamate synthetase B; NAAG synthetase B; NAAGS; Ribosomal protein S6 modification-like protein B", "protein_names_refseq": "N-acetyl-aspartyl-glutamate synthetase B; N-acetyl-aspartylglutamate synthetase B; N-acetylaspartyl-glutamate synthetase B; NAAG synthetase B; beta-citryl-glutamate synthase B; beta-citrylglutamate synthase B; family with sequence similarity 80, member B; ribosomal protein S6 modification-like protein B", "tax_id": 9913, "disease": "", "pathway": " (bta:538579); (R-BTA-8964539)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.41", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.41", "type": "external" }, { "id": "6.3.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity;GO:0072591 citrate-L-glutamate ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCE9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QE3-1", "uniprot_id": [ { "id": "GRL1A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QE3", "type": "external" } ], "mass": 41312.0, "length": 370, "protein_name": "DNA-directed RNA polymerase II subunit GRINL1A", "gene_name": "POLR2M", "organism": "Bovine", "refseq_name": "DNA-directed RNA polymerase II subunit GRINL1A", "refseq_ac": [ { "id": "NP_001098947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098947", "type": "external" } ], "gene_names_uniprotkb": "POLR2M; GRINL1A", "gene_names_refseq": "GRINL1A; POLR2M", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit GRINL1A; DNA-directed RNA polymerase II subunit M; GRINL1A downstream protein 1; Gdown1; Glutamate receptor-like protein 1A", "protein_names_refseq": "DNA-directed RNA polymerase II subunit GRINL1A; DNA-directed RNA polymerase II subunit M; GRINL1A downstream protein 1; gdown1; glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A; glutamate receptor-like protein 1A; polymerase (RNA) II (DNA directed) polypeptide M; protein GRINL1A", "tax_id": 9913, "disease": "", "pathway": " (bta:100125877)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16769904", "class_list": "", "function": "Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in Mediator complex-dependent regulation of transcription activation. Acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000993 RNA polymerase II complex binding;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005635 nuclear envelope;GO:0043025 neuronal cell body;GO:0031674 I band;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0051685 maintenance of ER location", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q17QE3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMJ5-1", "uniprot_id": [ { "id": "DRS7C_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMJ5", "type": "external" } ], "mass": 34422.0, "length": 311, "protein_name": "Dehydrogenase/reductase SDR family member 7C", "gene_name": "DHRS7C", "organism": "Bovine", "refseq_name": "dehydrogenase/reductase SDR family member 7C", "refseq_ac": [ { "id": "NP_001069013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069013", "type": "external" } ], "gene_names_uniprotkb": "DHRS7C; SDR32C2", "gene_names_refseq": "DHRS7C", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 7C; 1.1.1.105; Protein SDR32C2; Protein SRP-35; Sarcoplasmic reticulum protein of 35 kDa; Short-chain dehydrogenase/reductase family 32C member 2", "protein_names_refseq": "dehydrogenase/reductase SDR family member 7C; sarcoplasmic reticulum protein of 35 kDa; short-chain dehydrogenase/reductase family 32C member 2", "tax_id": 9913, "disease": "", "pathway": " (bta:511943)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal. Plays a role in the regulation of cardiac and skeletal muscle metabolic functions. Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal. Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes. Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" } ], "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0033017 sarcoplasmic reticulum membrane;GO:0014801 longitudinal sarcoplasmic reticulum", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0098708 D-glucose import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMJ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62964-1", "uniprot_id": [ { "id": "RABP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P62964", "type": "external" } ], "mass": 15592.0, "length": 137, "protein_name": "Cellular retinoic acid-binding protein 1", "gene_name": "CRABP1", "organism": "Bovine", "refseq_name": "cellular retinoic acid-binding protein 1", "refseq_ac": [ { "id": "NP_851371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851371", "type": "external" } ], "gene_names_uniprotkb": "CRABP1", "gene_names_refseq": "CRABP1", "protein_names_uniprotkb": "Cellular retinoic acid-binding protein 1; CRABP-I; Cellular retinoic acid-binding protein I", "protein_names_refseq": "CRABP-I; cellular retinoic acid-binding protein 1; cellular retinoic acid-binding protein I", "tax_id": 9913, "disease": "", "pathway": " (bta:282201); (R-BTA-5365859)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10531482;2581956;2833392;2856408;3039499;6269887;7704533", "class_list": "", "function": "Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02695;P02697;P15780;Q2KI87;Q5PXY6", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0042802 identical protein binding;GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0001972 retinoic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P62964-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJC1-1", "uniprot_id": [ { "id": "CDC5L_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJC1", "type": "external" } ], "mass": 92270.0, "length": 802, "protein_name": "Cell division cycle 5-like protein", "gene_name": "CDC5L", "organism": "Bovine", "refseq_name": "cell division cycle 5-like protein", "refseq_ac": [ { "id": "NP_001070010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070010", "type": "external" } ], "gene_names_uniprotkb": "CDC5L", "gene_names_refseq": "CDC5L", "protein_names_uniprotkb": "Cell division cycle 5-like protein; Cdc5-like protein", "protein_names_refseq": "CDC5 cell division cycle 5-like; cdc5-like protein; cell division cycle 5-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:767817); (R-BTA-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0005662 DNA replication factor A complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000398 mRNA splicing, via spliceosome;GO:0000077 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJC1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJG8-1", "uniprot_id": [ { "id": "BCKD_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJG8", "type": "external" } ], "mass": 46438.0, "length": 412, "protein_name": "Branched-chain alpha-ketoacid dehydrogenase kinase", "gene_name": "BCKDK", "organism": "Bovine", "refseq_name": "branched-chain alpha-ketoacid dehydrogenase kinase precursor", "refseq_ac": [ { "id": "NP_001039371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039371", "type": "external" } ], "gene_names_uniprotkb": "BCKDK", "gene_names_refseq": "BCKDK; BDK", "protein_names_uniprotkb": "Branched-chain alpha-ketoacid dehydrogenase kinase; 2.7.11.1; 2.7.11.4; BCKDH kinase; BCKDHKIN; BDK; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial", "protein_names_refseq": "BCKD-kinase; BCKDH kinase; BCKDHKIN; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; branched chain ketoacid dehydrogenase kinase; branched-chain alpha-ketoacid dehydrogenase kinase precursor; branched-chain alpha-ketoacid dehydrogenase kinase", "tax_id": 9913, "disease": "", "pathway": " (bta:505005); (R-BTA-70895)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with PPM1K, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (By similarity). Phosphorylates and inactivates mitochondrial BCKDH complex a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Associates with the E2 component of BCKDH complex and phosphorylates BCKDHA on Ser-347, leading to conformational changes that interrupt substrate channeling between E1 and E2 and inactivates the BCKDH complex (By similarity). Phosphorylates ACLY on Ser-455 in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and glucogenesis, respectively (By similarity). Recognizes phosphosites having SxxE/D canonical motif (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.2.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0008610 lipid biosynthetic process;GO:0010906 regulation of glucose metabolic process;GO:0009083 branched-chain amino acid catabolic process;GO:0010510 regulation of pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJG8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05589-1", "uniprot_id": [ { "id": "UROK_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05589", "type": "external" } ], "mass": 48730.0, "length": 433, "protein_name": "Urokinase-type plasminogen activator", "gene_name": "PLAU", "organism": "Bovine", "refseq_name": "urokinase-type plasminogen activator precursor", "refseq_ac": [ { "id": "NP_776572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776572", "type": "external" } ], "gene_names_uniprotkb": "PLAU", "gene_names_refseq": "PLAU", "protein_names_uniprotkb": "Urokinase-type plasminogen activator; 3.4.21.73; U-plasminogen activator; uPA", "protein_names_refseq": "U-plasminogen activator; uPA; urokinase plasminogen activator preproprotein; urokinase-type plasminogen activator precursor; urokinase-type plasminogen activator", "tax_id": 9913, "disease": "", "pathway": " (bta:281408); (R-BTA-6798695); (R-BTA-75205)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15128599;16305752;22177313;24981429;25939353;28667127;29880066;8385052", "class_list": "", "function": "Data show that urokinase-type plasminogen activator (uPA) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1) are expressed in both the cumulus cells and the immature and in vitro matured oocytes., [RefSeq, PubMed]; Data suggest endogenous uPA activity plays important role in oocyte maturation; these studies were conducted using in vitro oocyte maturation techniques., [RefSeq, PubMed]; Serine protease that cleaves the inactive precursor plasminogen at a specific Arg-Val peptide bond, converting it into active plasmin. Secreted as an inactive zymogen, it is recruited and activated at the cell surface through interaction with the urokinase plasminogen activator receptor (uPAR). Cell-surface activation enables localized, plasmin-dependent pericellular proteolysis, regulating extracellular matrix degradation in cell migration and tissue remodeling (By similarity). Also contributes to fibrinolysis and blood clot clearance by promoting plasmin generation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin., [UniProtKB, UniProtKB]; Stage-dependent regulation of granulosa cell PA and SerpinE2 production, consistent with a role in extracellular matrix remodeling during follicle growth., [RefSeq, PubMed]; The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte., [RefSeq, PubMed]; UPA/uPAR binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment., [RefSeq, PubMed]; Urokinase plasminogen activator expression in the oviducts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7E3W6;Q0IIG3;Q28209", "ec_number_list": [ { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.7", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005576 extracellular region", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:2000097 regulation of smooth muscle cell-matrix adhesion;GO:0014910 regulation of smooth muscle cell migration;GO:0042730 fibrinolysis;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q05589-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28057-1", "uniprot_id": [ { "id": "PAG2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28057", "type": "external" } ], "mass": 41907.0, "length": 376, "protein_name": "Pregnancy-associated glycoprotein 2", "gene_name": "PAG2", "organism": "Bovine", "refseq_name": "pregnancy-associated glycoprotein 2 precursor", "refseq_ac": [ { "id": "NP_788787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788787", "type": "external" } ], "gene_names_uniprotkb": "PAG2", "gene_names_refseq": "PAG2", "protein_names_uniprotkb": "Pregnancy-associated glycoprotein 2; 3.4.23.-; PAG 2", "protein_names_refseq": "PAG 2; pregnancy-associated glycoprotein 2 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:337897)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17071780;23228018;24456132;26936628;27045629;7534122", "class_list": "", "function": "PAG2 or a processed derivative of this molecule might represent a factor that binds the LH receptor., [UniProtKB]; Plasma pregnancy-associated glycoprotein-2 concentrations measured using anti-bovine pregnancy-associated glycoprotein-2 antiserum on Day 120 of gestation could serve as an indicator of the abortion risk in Neospora caninum infected animals, [RefSeq, PubMed]; The clinical implications of these findings are that following infection with N. caninum, most cows will experience some level of placental damage and that this injury correlates with foetal fluid PAG levels and pH., [RefSeq, PubMed]; These findings indicate that IFN-gamma production correlates negatively and the production of antibodies against N. caninum is uncorrelated with plasma pregnancy-associated glycoproteins levels., [RefSeq, PubMed]; This study examines expression patterns of the genes SERPINA14, PAG, and PAG2 at the fetal-maternal interface in dairy heifers experimentally infected with N caninum during the second trimester of pregnancy, when most abortions takes place in natural conditions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q28057-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II76-1", "uniprot_id": [ { "id": "GBRR2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II76", "type": "external" } ], "mass": 54122.0, "length": 465, "protein_name": "Gamma-aminobutyric acid receptor subunit rho-2", "gene_name": "GABRR1; GABRR2", "organism": "Bovine", "refseq_name": "gamma-aminobutyric acid receptor subunit rho-2 precursor", "refseq_ac": [ { "id": "NP_001071414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071414", "type": "external" } ], "gene_names_uniprotkb": "GABRR1; GABRR2; GABRR2", "gene_names_refseq": "GABRR2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit rho-2; GABA(A) receptor subunit rho-2; GABA(C) receptor; GABAAR subunit rho-2", "protein_names_refseq": "GABA(A) receptor subunit rho-2; GABA(C) receptor; gamma-aminobutyric acid (GABA) receptor, rho 2; gamma-aminobutyric acid receptor subunit rho-2 precursor; gamma-aminobutyric acid receptor subunit rho-2; gamma-aminobutyric acid type A receptor rho2 subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:522099); (R-BTA-977443)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Rho-2 GABAARs may contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission. Rho-2 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-2 GABAARs expressed in retina may play a role in retinal neurotransmission (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:0005254 chloride channel activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex;GO:0098978 glutamatergic synapse", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II76-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47798-1", "uniprot_id": [ { "id": "MSHR_BOVIN", "url": "https://www.uniprot.org/uniprot/P47798", "type": "external" } ], "mass": 34916.0, "length": 317, "protein_name": "Melanocyte-stimulating hormone receptor", "gene_name": "MC1R", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MC1R; MSHR", "gene_names_refseq": "", "protein_names_uniprotkb": "Melanocyte-stimulating hormone receptor; BDF3; MC1-R; MSH-R; Melanocortin receptor 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-375276); (R-BTA-418555)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10628296;8034052;8661706", "class_list": "", "function": "G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and adrenocorticotropic hormone/ACTH, which are peptide products of the POMC precursor protein. Upon activation, MC1R couples with the G(s) protein, stimulating adenylate cyclase and activating the cAMP-dependent signaling pathway (PubMed:8034052). This activation promotes melanogenesis, resulting in the production of eumelanin (black/brown) and pheomelanin (red/yellow) in melanocytes. MC1R interacts with G protein-coupled receptor opsin 3/OPN3, which couples to G(i) proteins and inhibits the alpha-MSH-induced cAMP response, thereby reducing melanin synthesis (By similarity). Binding to Agouti/ASP precludes alpha-MSH-induced signaling, thereby downregulating melanogenesis (By similarity). Additionally, interaction with MGRN1 displaces the G(s) protein, further suppressing MC1R signaling (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q28025", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0004978 corticotropin receptor activity;GO:0004980 melanocyte-stimulating hormone receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032720 negative regulation of tumor necrosis factor production;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P47798-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47803-1", "uniprot_id": [ { "id": "RGR_BOVIN", "url": "https://www.uniprot.org/uniprot/P47803", "type": "external" } ], "mass": 31961.0, "length": 291, "protein_name": "RPE-retinal G protein-coupled receptor", "gene_name": "RGR", "organism": "Bovine", "refseq_name": "RPE-retinal G protein-coupled receptor", "refseq_ac": [ { "id": "NP_786969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786969", "type": "external" } ], "gene_names_uniprotkb": "RGR", "gene_names_refseq": "RGR", "protein_names_uniprotkb": "RPE-retinal G protein-coupled receptor; RGR opsin", "protein_names_refseq": "RPE-retinal G protein-coupled receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:280911); (R-BTA-418594); (R-BTA-419771)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "30034210;7947717;8258527", "class_list": "", "function": "Non-visual opsin that functions as a light-dependent facilitator of retinoid isomerization and trafficking in retinal pigment epithelium (RPE) and Mueller glia (PubMed:7947717). Participates in a photic visual cycle by complementing the classical enzymatic RPE65/RDH pathway for chromophore regeneration (By similarity). Binds all-trans-retinal via a conserved Schiff-base lysine and, upon illumination, promotes photoisomerization of all-trans-retinal to 11-cis-retinal required for regeneration of visual pigments (PubMed:7947717). Also mediates light-dependent mobilization of stored all-trans-retinyl esters from lipid droplets to endoplasmic reticulum membranes, facilitating their processing into 11-cis-retinoids (By similarity). May also modulate isomerohydrolase activity independent of light (By similarity). Although RGR is structurally a GPCR-family opsin, there is no consistent evidence that RGR activates G proteins or initiates a canonical second-messenger signaling cascade (Probable)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The results indicate that the cone photoreceptors of humans and cattle express a nonvisual opsin of the Go/RGR or tetraopsin group. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q148K9", "ec_number_list": [], "go_molecular_function": "GO:0016918 retinal binding;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P47803-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48042-1", "uniprot_id": [ { "id": "P2RY1_BOVIN", "url": "https://www.uniprot.org/uniprot/P48042", "type": "external" } ], "mass": 42288.0, "length": 373, "protein_name": "P2Y purinoceptor 1", "gene_name": "P2RY1", "organism": "Bovine", "refseq_name": "P2Y purinoceptor 1", "refseq_ac": [ { "id": "NP_776835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776835", "type": "external" } ], "gene_names_uniprotkb": "P2RY1", "gene_names_refseq": "P2RY1; P2Y1", "protein_names_uniprotkb": "P2Y purinoceptor 1; ATP receptor; P2Y1; Purinergic receptor", "protein_names_refseq": "ATP receptor; P2Y purinoceptor 1; p2y1 purinoceptor; purinergic receptor P2Y, G-protein coupled, 1", "tax_id": 9913, "disease": "", "pathway": " (bta:281963); (R-BTA-416476); (R-BTA-417957); (R-BTA-418592)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "20962269;23376159;24550450;7626079;9848096", "class_list": "", "function": "P2Y1 and P2Y13 receptors play a major role in vasa vasorum endothelial cells growth responses., [RefSeq, PubMed]; P2Y1 receptor-mediated responses involve Flt3 transactivation, and may identify a unique mechanism whereby cancer chemotherapy with receptor tyrosine kinase inhibitors promotes vascular dysfunction., [RefSeq, PubMed]; Purinergic P2Y1 receptor signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts., [RefSeq, PubMed]; Receptor for extracellular adenine nucleotides such as ADP (PubMed:7626079). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001621 G protein-coupled ADP receptor activity;GO:0031686 A1 adenosine receptor binding;GO:0045031 G protein-coupled ATP receptor activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0090075 relaxation of muscle;GO:0030168 platelet activation;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0008360 regulation of cell shape;GO:0071415 cellular response to purine-containing compound", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P48042-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48044-1", "uniprot_id": [ { "id": "V2R_BOVIN", "url": "https://www.uniprot.org/uniprot/P48044", "type": "external" } ], "mass": 40236.0, "length": 370, "protein_name": "Vasopressin V2 receptor", "gene_name": "AVPR2", "organism": "Bovine", "refseq_name": "vasopressin V2 receptor", "refseq_ac": [ { "id": "NP_776671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776671", "type": "external" } ], "gene_names_uniprotkb": "AVPR2", "gene_names_refseq": "AVPR2", "protein_names_uniprotkb": "Vasopressin V2 receptor; AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor; V2R", "protein_names_refseq": "AVPR V2; V2R; antidiuretic hormone receptor; arginine vasopressin receptor 2 (nephrogenic diabetes insipidus); renal-type arginine vasopressin receptor; vasopressin V2 receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281642); (R-BTA-388479); (R-BTA-418555); (R-BTA-432040); (R-BTA-8856825); (R-BTA-8856828)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "7698346;8257689", "class_list": "", "function": "G protein-coupled receptor for arginine vasopressin, an antidiuretic that promotes renal water reabsorption (PubMed:7698346, PubMed:8257689). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (By similarity). AVPR2 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0032870 cellular response to hormone stimulus;GO:0045907 positive regulation of vasoconstriction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48044-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49410-1", "uniprot_id": [ { "id": "EFTU_BOVIN", "url": "https://www.uniprot.org/uniprot/P49410", "type": "external" } ], "mass": 49398.0, "length": 452, "protein_name": "Elongation factor Tu, mitochondrial", "gene_name": "TUFM", "organism": "Bovine", "refseq_name": "elongation factor Tu, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776632", "type": "external" } ], "gene_names_uniprotkb": "TUFM", "gene_names_refseq": "TUFM", "protein_names_uniprotkb": "Elongation factor Tu, mitochondrial; 3.6.5.3; EF-Tu", "protein_names_refseq": "EF-Tu; elongation factor Tu, mitochondrial precursor; elongation factor Tu, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:281556)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10715211;12445479;15557323;17130126;17179748;20435138;2808417;41018975;8547323;8652669", "class_list": "", "function": "GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (PubMed:2808417, PubMed:8652669). Participates in mitochondrial translation (PubMed:2808417, PubMed:8652669). Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Isolation, crystallisation, and preliminary X-ray analysis, [RefSeq, PubMed]; Loss of activity is caused by a significant reduction in the ability of EF-Ts(mt) R325W to bind EF-Tu(mt), leading to a defect in nucleotide exchange., [RefSeq, PubMed]; Recombinant mitochondrial EF-Tu prevents thermal aggregation of proteins and enhances protein refolding in vitro., [RefSeq, PubMed]; The arginine residue at position 335 of bovine mitochondrial elongation factor Tu (EF-Tu) plays an important role in the binding and EF-Tu-mediated delivery of mitochondrial aminoacyl-tRNAs to the A-site of the ribosome., [RefSeq, PubMed]; X-ray crystallographic structure of the EF-Tumt.Tsmt complex, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VCL4", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070125 mitochondrial translational elongation;GO:0006414 translational elongation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P49410-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49872-1", "uniprot_id": [ { "id": "F261_BOVIN", "url": "https://www.uniprot.org/uniprot/P49872", "type": "external" } ], "mass": 54657.0, "length": 471, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1", "gene_name": "PFKFB1", "organism": "Bovine", "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1", "refseq_ac": [ { "id": "NP_776997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776997", "type": "external" } ], "gene_names_uniprotkb": "PFKFB1", "gene_names_refseq": "PFKFB1", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme; PFK/FBPase 1", "protein_names_refseq": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ASE liver isozyme; 6PF-2-K/Fru-2,6-P2ase 1; PFK/FBPase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282304)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1654864", "class_list": "", "function": "Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.105", "type": "external" }, { "id": "3.1.3.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.46", "type": "external" } ], "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0003873 6-phosphofructo-2-kinase activity", "go_cellular_component": "GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;GO:0005829 cytosol", "go_biological_process": "GO:0006000 fructose metabolic process;GO:0006003 fructose 2,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P49872-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49876-1", "uniprot_id": [ { "id": "IFNAF_BOVIN", "url": "https://www.uniprot.org/uniprot/P49876", "type": "external" } ], "mass": 21290.0, "length": 189, "protein_name": "Interferon alpha-F", "gene_name": "IFNAF", "organism": "Bovine", "refseq_name": "interferon alpha-F precursor", "refseq_ac": [ { "id": "NP_001165513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165513", "type": "external" } ], "gene_names_uniprotkb": "IFNAF; IFNA6", "gene_names_refseq": "IF1AG3; IFN-alpha6; IFNA6; IFNAF; INFAF", "protein_names_uniprotkb": "Interferon alpha-F; IFN-alpha6", "protein_names_refseq": "interferon 1AG3; interferon alpha-F precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:100329210)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8662077", "class_list": "", "function": "Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P49876-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49877-1", "uniprot_id": [ { "id": "IFNAG_BOVIN", "url": "https://www.uniprot.org/uniprot/P49877", "type": "external" } ], "mass": 21588.0, "length": 189, "protein_name": "Interferon alpha-G", "gene_name": "IFNAG", "organism": "Bovine", "refseq_name": "interferon alpha-G precursor", "refseq_ac": [ { "id": "NP_001165511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165511", "type": "external" } ], "gene_names_uniprotkb": "IFNAG; IFNA7", "gene_names_refseq": "IF1AG6; IFNAG", "protein_names_uniprotkb": "Interferon alpha-G; IFN-alpha7", "protein_names_refseq": "IFN-alpha7; interferon 1AG6; interferon alpha-G precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:100329206)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8662077", "class_list": "", "function": "Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P49877-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49878-1", "uniprot_id": [ { "id": "IFNAH_BOVIN", "url": "https://www.uniprot.org/uniprot/P49878", "type": "external" } ], "mass": 21479.0, "length": 189, "protein_name": "Interferon alpha-H", "gene_name": "IFNAH", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IFNAH; IFNA8", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon alpha-H; IFN-alpha8", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:100329207)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8662077", "class_list": "", "function": "Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P49878-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49907-1", "uniprot_id": [ { "id": "SEPP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P49907", "type": "external" } ], "mass": 45488.0, "length": 402, "protein_name": "Selenoprotein P", "gene_name": "SELENOP", "organism": "Bovine", "refseq_name": "selenoprotein P precursor", "refseq_ac": [ { "id": "NP_776884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776884", "type": "external" } ], "gene_names_uniprotkb": "SELENOP", "gene_names_refseq": "SELENOP; SELP; SEPP1", "protein_names_uniprotkb": "Selenoprotein P; SeP; Selenoprotein P-like protein", "protein_names_refseq": "seP; selenoprotein P precursor; selenoprotein P, plasma, 1; selenoprotein P-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:282066)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26495903;7637580;9358058", "class_list": "", "function": "Constitutes a major selenium pool in the brain and may play an important role in developing and/or modulating the morphology of neurons and/or glial cells., [UniProtKB, PubMed]; This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (12 in cow), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. [provided by RefSeq, Feb 2017]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O19003;Q9N2H6", "ec_number_list": [], "go_molecular_function": "GO:0008430 selenium binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P49907-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50227-1", "uniprot_id": [ { "id": "ST1A1_BOVIN", "url": "https://www.uniprot.org/uniprot/P50227", "type": "external" } ], "mass": 34184.0, "length": 295, "protein_name": "Sulfotransferase 1A1", "gene_name": "SULT1A1", "organism": "Bovine", "refseq_name": "sulfotransferase 1A1 isoform 1", "refseq_ac": [ { "id": "NP_001421834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421834", "type": "external" } ], "gene_names_uniprotkb": "SULT1A1; STP", "gene_names_refseq": "P-PST; ST1A1; SULT1A1", "protein_names_uniprotkb": "Sulfotransferase 1A1; 2.8.2.1; Aryl sulfotransferase; P-PST; Phenol sulfotransferase; Phenol-sulfating phenol sulfotransferase; ST1A1", "protein_names_refseq": "aryl sulfotransferase; phenol sulfotransferase; phenol-sulfating phenol sulfotransferase; sulfotransferase 1A1 isoform 1; sulfotransferase 1A1", "tax_id": 9913, "disease": "", "pathway": " (bta:282485); (R-BTA-156584); (R-BTA-9753281)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "7575456;8890738", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. Catalyzes the sulfate conjugation of dopamine. Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0S9", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.4", "type": "external" }, { "id": "2.8.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.1", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051923 sulfation;GO:0042420 dopamine catabolic process;GO:0008202 steroid metabolic process;GO:0042403 thyroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P50227-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50243-1", "uniprot_id": [ { "id": "DCAM_BOVIN", "url": "https://www.uniprot.org/uniprot/P50243", "type": "external" } ], "mass": 38365.0, "length": 334, "protein_name": "S-adenosylmethionine decarboxylase proenzyme", "gene_name": "AMD1", "organism": "Bovine", "refseq_name": "S-adenosylmethionine decarboxylase proenzyme", "refseq_ac": [ { "id": "NP_776415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776415", "type": "external" } ], "gene_names_uniprotkb": "AMD1", "gene_names_refseq": "AMD1", "protein_names_uniprotkb": "S-adenosylmethionine decarboxylase proenzyme; 4.1.1.50; AdoMetDC; SAMDC", "protein_names_refseq": "S-adenosylmethionine decarboxylase 1; S-adenosylmethionine decarboxylase proenzyme; SAMDC; adoMetDC", "tax_id": 9913, "disease": "", "pathway": " (bta:280997); (R-BTA-351202)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "3017942;8416975", "class_list": "", "function": "Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08DE3", "ec_number_list": [ { "id": "4.1.1.50", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.50", "type": "external" } ], "go_molecular_function": "GO:0019810 putrescine binding;GO:0004014 adenosylmethionine decarboxylase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006597 spermine biosynthetic process;GO:0008295 spermidine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P50243-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50448-1", "uniprot_id": [ { "id": "F12AI_BOVIN", "url": "https://www.uniprot.org/uniprot/P50448", "type": "external" } ], "mass": 51723.0, "length": 468, "protein_name": "Factor XIIa inhibitor", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Factor XIIa inhibitor; XIIaINH", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281035)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "30573663;3814612;8457651", "class_list": "", "function": "May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007596 blood coagulation;GO:0042730 fibrinolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P50448-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52476-1", "uniprot_id": [ { "id": "AL1B1_BOVIN", "url": "https://www.uniprot.org/uniprot/P52476", "type": "external" } ], "mass": 58178.0, "length": 524, "protein_name": "Aldehyde dehydrogenase family 1 member B1, mitochondrial", "gene_name": "ALDH1B1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ALDH1B1; ALDHX", "gene_names_refseq": "", "protein_names_uniprotkb": "Aldehyde dehydrogenase family 1 member B1, mitochondrial; 1.2.1.28; 1.2.1.36; 1.2.1.3; 1.7.1.-; Nitroglycerin reductase ALDH1B1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8493893", "class_list": "", "function": "Broad specificity, mitochondrial aldehyde dehydrogenase that could play a role in the detoxification of alcohol-derived acetaldehyde and other aldehydes. Shows an absolute preference for NAD(+) as no activity is detected with NADP(+). Has a high affinity and catalytic efficiency toward aliphatic medium-chain saturated aldehydes relative to short-chain and aromatic aldehydes in vitro. Also capable of metabolizing products of lipid peroxidation, namely 4-hydroxynon-2-enal(4-HNE) and malonaldehyde (MDA) but with lower catalytic efficiency. In vitro, it can also display a nitroglycerin reductase activity. Has also an esterase activity in vitro, but this may be not physiologically relevant in vivo., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G5E5P4", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" } ], "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006068 ethanol catabolic process;GO:0006081 aldehyde metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P52476-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54281-1", "uniprot_id": [ { "id": "CLCA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P54281", "type": "external" } ], "mass": 100306.0, "length": 903, "protein_name": "Calcium-activated chloride channel regulator 1", "gene_name": "", "organism": "Bovine", "refseq_name": "calcium-activated chloride channel regulator 1 precursor", "refseq_ac": [ { "id": "NP_001229512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229512", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "LOC784768", "protein_names_uniprotkb": "Calcium-activated chloride channel regulator 1; 3.4.-.-; Calcium-activated chloride channel; Epithelial chloride channel protein", "protein_names_refseq": "calcium-activated chloride channel regulator 1 precursor; calcium-activated chloride channel regulator 1; epithelial chloride channel protein", "tax_id": 9913, "disease": "", "pathway": " (bta:784768)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8537359", "class_list": "", "function": "May be involved in mediating calcium-activated chloride conductance (PubMed:8537359). May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006816 calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P54281-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55052-1", "uniprot_id": [ { "id": "FABP5_BOVIN", "url": "https://www.uniprot.org/uniprot/P55052", "type": "external" } ], "mass": 15074.0, "length": 135, "protein_name": "Fatty acid-binding protein 5", "gene_name": "FABP5", "organism": "Bovine", "refseq_name": "fatty acid-binding protein 5", "refseq_ac": [ { "id": "NP_776740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776740", "type": "external" } ], "gene_names_uniprotkb": "FABP5", "gene_names_refseq": "FABP5", "protein_names_uniprotkb": "Fatty acid-binding protein 5; Differentiation-associated lipid-binding protein LP2; E-FABP; Epidermal-type fatty acid-binding protein; Fatty acid-binding protein, epidermal", "protein_names_refseq": "E-FABP; differentiation-associated lipid-binding protein LP2; epidermal fatty acid-binding protein; epidermal-type fatty acid-binding protein; fatty acid binding protein 5 (psoriasis-associated); fatty acid-binding protein 5; fatty acid-binding protein, epidermal", "tax_id": 9913, "disease": "", "pathway": " (bta:281760); (R-BTA-163560); (R-BTA-5362517); (R-BTA-6798695)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "16305752;30071125;8947466;9521644", "class_list": "", "function": "Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; We further uncovered that fatty acids are needed for FABP5-mediated SREBP-1c gene expression. Thus, our study demonstrates that FABP5 is a critical regulator of Met- and E2-induced SREBP-1c gene expression leading to milk fat synthesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O62808;Q5E9D9", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005504 fatty acid binding;GO:0042802 identical protein binding;GO:0001972 retinoic acid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0098921 retrograde trans-synaptic signaling by endocannabinoid;GO:1990379 lipid transport across blood-brain barrier;GO:0031392 regulation of prostaglandin biosynthetic process;GO:0099178 regulation of retrograde trans-synaptic signaling by endocanabinoid;GO:0051930 regulation of sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55052-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55106-1", "uniprot_id": [ { "id": "GDF6_BOVIN", "url": "https://www.uniprot.org/uniprot/P55106", "type": "external" } ], "mass": 52112.0, "length": 470, "protein_name": "Growth/differentiation factor 6", "gene_name": "GDF6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GDF6; BMP13; CDMP2", "gene_names_refseq": "", "protein_names_uniprotkb": "Growth/differentiation factor 6; BMP-13; Bone morphogenetic protein 13; CDMP-2; Cartilage-derived morphogenetic protein 2; GDF-6", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:407175)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19393038;7961761", "class_list": "", "function": "Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG. Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F1MD30", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006915 apoptotic process;GO:0030509 BMP signaling pathway;GO:0045444 fat cell differentiation;GO:0032332 positive regulation of chondrocyte differentiation;GO:1900745 positive regulation of p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P55106-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55252-1", "uniprot_id": [ { "id": "HPLN1_BOVIN", "url": "https://www.uniprot.org/uniprot/P55252", "type": "external" } ], "mass": 40288.0, "length": 354, "protein_name": "Hyaluronan and proteoglycan link protein 1", "gene_name": "HAPLN1", "organism": "Bovine", "refseq_name": "hyaluronan and proteoglycan link protein 1 precursor", "refseq_ac": [ { "id": "NP_776713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776713", "type": "external" } ], "gene_names_uniprotkb": "HAPLN1; CRTL1", "gene_names_refseq": "CRTL1; HAPLN1; LP", "protein_names_uniprotkb": "Hyaluronan and proteoglycan link protein 1; Cartilage-link protein; Cartilage-linking protein 1; Proteoglycan link protein", "protein_names_refseq": "cartilage linking protein 1; cartilage-link protein; hyaluronan and proteoglycan link protein 1 precursor; proteoglycan link protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281717); (R-BTA-3000178)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12647302;7584851", "class_list": "", "function": "Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix., [UniProtKB, UniProtKB, UniProtKB]; Stimulates proteoglycan and types II and IX collagens in intervertebral disc cells - stimulates synthesis of matrix molecules, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0072534 perineuronal net;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P55252-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55943-1", "uniprot_id": [ { "id": "MT2H_BOVIN", "url": "https://www.uniprot.org/uniprot/P55943", "type": "external" } ], "mass": 5956.0, "length": 61, "protein_name": "Metallothionein-II, hippocampal", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Metallothionein-II, hippocampal; MT-2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8780044", "class_list": "", "function": "Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. This isoform may play a role in regulating the transport, accumulation, and compartmentation of zinc in the hippocampus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071276 cellular response to cadmium ion;GO:0071280 cellular response to copper ion;GO:0010273 detoxification of copper ion;GO:0006882 intracellular zinc ion homeostasis;GO:0071294 cellular response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P55943-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56413-1", "uniprot_id": [ { "id": "AGRP_BOVIN", "url": "https://www.uniprot.org/uniprot/P56413", "type": "external" } ], "mass": 14706.0, "length": 134, "protein_name": "Agouti-related protein", "gene_name": "AGRP", "organism": "Bovine", "refseq_name": "agouti-related protein precursor", "refseq_ac": [ { "id": "NP_776408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776408", "type": "external" } ], "gene_names_uniprotkb": "AGRP; AGRT; ART", "gene_names_refseq": "AGRP", "protein_names_uniprotkb": "Agouti-related protein", "protein_names_refseq": "agouti-related protein precursor; agouti-related protein", "tax_id": 9913, "disease": "", "pathway": " (bta:280987)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14592963;15544862", "class_list": "", "function": "(Nle4, d-Phe7)-alphaMSH (NDP-alphaMSH) stimulated the production of cortisol and these effects were abolished by agouti related protein or SHU9119, a synthetic antagonist of melanocortin 3 and melanocortin 4 receptor, [RefSeq, PubMed]; Agrp inhibited, in a dose-dependent manner, the 10(-9) M NDP-alphaMSH-induced cortisol production through its antagonistic properties towards MSH at the level of MC4-R, [RefSeq, PubMed]; Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptors MC3R and MC4R by precluding agonist-induced signaling, thereby inhibiting cAMP production within the hypothalamus and adrenal gland. Involved in the control of feeding behavior via the central melanocortin system. Has very low activity towards MC5R. Also promotes endocytosis of MC3R and MC4R in an arrestin-dependent mechanism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031781 type 3 melanocortin receptor binding;GO:0031782 type 4 melanocortin receptor binding;GO:0070996 type 1 melanocortin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005796 Golgi lumen", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0032098 regulation of appetite;GO:0008343 adult feeding behavior;GO:0009755 hormone-mediated signaling pathway;GO:2000253 positive regulation of feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P56413-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56449-1", "uniprot_id": [ { "id": "OXYR_BOVIN", "url": "https://www.uniprot.org/uniprot/P56449", "type": "external" } ], "mass": 43378.0, "length": 391, "protein_name": "Oxytocin receptor", "gene_name": "OXTR", "organism": "Bovine", "refseq_name": "oxytocin receptor", "refseq_ac": [ { "id": "NP_776559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776559", "type": "external" } ], "gene_names_uniprotkb": "OXTR", "gene_names_refseq": "OXTR", "protein_names_uniprotkb": "Oxytocin receptor; OT-R", "protein_names_refseq": "OT-R; oxytocin receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281371); (R-BTA-388479); (R-BTA-416476)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12604656;12935872;12957670;18094352;18832100;20149890;31504215;8534370", "class_list": "", "function": "Components of the interferon system are found to significantly influence the transcription of the bovine oxytocin receptor gene., [RefSeq, PubMed]; G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C. OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity. Central release of oxytocin plays essential roles in social behavior, such as maternal care, social cognition and affiliative behaviors, triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory). Peripheral release of oxytocin (secretion into the bloodstream) promotes various processes, such as parturition, lactation or osteoblast differentiation. OXTR-mediated signaling promotes milk ejection by triggering and strengthening contraction of the smooth muscle of mammary gland., [UniProtKB, UniProtKB]; Oxytocin receptor down-regulation is not necessary for reducing oxytocin-induced prostaglandin F(2alpha) accumulation by interferon-tau in a bovine endometrial epithelial cell line., [RefSeq, PubMed]; Relationship between luteal concentrations of oxytocin (OT), noradrenaline (NA), progesterone (P4), oxytocin receptors (OT-R) and beta(2)-adrenoreceptors (beta(2)-R) gene expression and their protein level throughout the estrous cycle, [RefSeq, PubMed]; Study demonstrated that bovine lymphocytes express oxytocin receptors and that this expression can be regulated in a steroid-dependent manner, [RefSeq, PubMed]; The presence of oxytocin receptors (OTR) in oviductal tissues is evident in the follicular phase cow, [RefSeq, PubMed]; These data show that E2 can stimulate PGF2 alpha secretion by increasing OXTR expression in bovine endometrial cells in vitro, but only after exposure to P4., [RefSeq, PubMed]; Up-regulation of endometrial oxytocin receptor is associated with the timing of luteolysis in heifers with two and three follicular wavesdagger., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004990 oxytocin receptor activity;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007565 female pregnancy;GO:0032870 cellular response to hormone stimulus;GO:0045907 positive regulation of vasoconstriction;GO:0060137 maternal process involved in parturition", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P56449-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56717-1", "uniprot_id": [ { "id": "OREX_BOVIN", "url": "https://www.uniprot.org/uniprot/P56717", "type": "external" } ], "mass": 13465.0, "length": 131, "protein_name": "Hypocretin neuropeptide precursor", "gene_name": "HCRT", "organism": "Bovine", "refseq_name": "hypocretin neuropeptide precursor precursor", "refseq_ac": [ { "id": "NP_001159992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159992", "type": "external" } ], "gene_names_uniprotkb": "HCRT; OX; PPOX", "gene_names_refseq": "HCRT", "protein_names_uniprotkb": "Hypocretin neuropeptide precursor; Hcrt1; Hcrt2; Hcrt; Hypocretin-1; Hypocretin-2; Hypocretin; Orexin precursor; Prepro-orexin; Preprohypocretin", "protein_names_refseq": "hcrt1; hypocretin (orexin) neuropeptide; hypocretin neuropeptide precursor precursor; hypocretin-1; orexin-A; prepro-orexin; preprohypocretin", "tax_id": 9913, "disease": "", "pathway": " (bta:281222); (R-BTA-389397); (R-BTA-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "18213704;19089887;20359730;23264212;9491897", "class_list": "", "function": "Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity)., [UniProtKB, UniProtKB]; Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity)., [UniProtKB, UniProtKB]; First evidence for the expression of oxA and ox1R in the vestibular glands of mammalian genital tract, [RefSeq, PubMed]; Locally synthesized in the urethroprostatic complex, [RefSeq, PubMed]; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested., [UniProtKB, UniProtKB]; Orexin A was found in the beta cells of cattle, sheep, and swine where it may be implicated in the control of pancreatic activity., [RefSeq, PubMed]; The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MRP1", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031771 type 1 orexin receptor binding;GO:0031772 type 2 orexin receptor binding", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0007218 neuropeptide signaling pathway;GO:0042594 response to starvation;GO:0042755 eating behavior;GO:0046928 regulation of neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P56717-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58280-1", "uniprot_id": [ { "id": "MT1_BOVIN", "url": "https://www.uniprot.org/uniprot/P58280", "type": "external" } ], "mass": 5992.0, "length": 61, "protein_name": "Metallothionein-1", "gene_name": "MT1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Metallothionein-1; MT-1; MT-I; Metallothionein-I", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "4019500", "class_list": "", "function": "Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071276 cellular response to cadmium ion;GO:0071280 cellular response to copper ion;GO:0010273 detoxification of copper ion;GO:0006882 intracellular zinc ion homeostasis;GO:0071294 cellular response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P58280-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58351-1", "uniprot_id": [ { "id": "GTR2_BOVIN", "url": "https://www.uniprot.org/uniprot/P58351", "type": "external" } ], "mass": 56060.0, "length": 510, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 2", "gene_name": "SLC2A2", "organism": "Bovine", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 2", "refseq_ac": [ { "id": "NP_001096692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096692", "type": "external" } ], "gene_names_uniprotkb": "SLC2A2; GLUT2", "gene_names_refseq": "SLC2A2", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 2; GLUT-2; Glucose transporter type 2, liver", "protein_names_refseq": "GLUT-2; glucose transporter type 2, liver; solute carrier family 2 (facilitated glucose transporter), member 2; solute carrier family 2, facilitated glucose transporter member 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282357); (R-BTA-189200); (R-BTA-422356); (R-BTA-8981373)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11599048;22221035", "class_list": "", "function": "Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of beta cells. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate and urate., [UniProtKB, UniProtKB]; The coding regions of GHSR and SLC2A2 were sequenced in 12 animals with extreme phenotypes for feed intake and gain; Sixteen SNPs were identified in SLC2A2, and three were detected in GHSR., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6QPH3", "ec_number_list": [], "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016324 apical plasma membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0015755 fructose transmembrane transport;GO:0015757 galactose transmembrane transport;GO:1990539 fructose import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P58351-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58352-1", "uniprot_id": [ { "id": "GTR3_BOVIN", "url": "https://www.uniprot.org/uniprot/P58352", "type": "external" } ], "mass": 54020.0, "length": 494, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 3", "gene_name": "SLC2A3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC2A3; GLUT3", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 3; GLUT-3; Glucose transporter type 3, brain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "41018975", "class_list": "", "function": "Facilitative glucose transporter. Can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Required for mesendoderm differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005536 D-glucose binding;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043204 perikaryon;GO:0042995 cell projection", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0015757 galactose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P58352-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58754-1", "uniprot_id": [ { "id": "LY96_BOVIN", "url": "https://www.uniprot.org/uniprot/P58754", "type": "external" } ], "mass": 18484.0, "length": 160, "protein_name": "Lymphocyte antigen 96", "gene_name": "LY96", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LY96; MD2", "gene_names_refseq": "", "protein_names_uniprotkb": "Lymphocyte antigen 96; Ly-96; Protein MD-2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "17559944", "class_list": "", "function": "Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (By similarity). Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0035662 Toll-like receptor 4 binding;GO:0001875 lipopolysaccharide immune receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0046696 lipopolysaccharide receptor complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0071222 cellular response to lipopolysaccharide;GO:0032760 positive regulation of tumor necrosis factor production;GO:0031663 lipopolysaccharide-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P58754-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59837-1", "uniprot_id": [ { "id": "RDH12_BOVIN", "url": "https://www.uniprot.org/uniprot/P59837", "type": "external" } ], "mass": 35171.0, "length": 316, "protein_name": "Retinol dehydrogenase 12", "gene_name": "RDH12", "organism": "Bovine", "refseq_name": "retinol dehydrogenase 12", "refseq_ac": [ { "id": "NP_899207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899207", "type": "external" } ], "gene_names_uniprotkb": "RDH12; DSSDR2", "gene_names_refseq": "DSSDR2; RDH12", "protein_names_uniprotkb": "Retinol dehydrogenase 12; 1.1.1.300; Double substrate specificity short-chain dehydrogenase/reductase 2", "protein_names_refseq": "double substrate specificity short-chain dehydrogenase/reductase 2; retinol dehydrogenase 12 (all-trans/9-cis/11-cis); retinol dehydrogenase 12", "tax_id": 9913, "disease": "", "pathway": " (bta:369021)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12226107", "class_list": "", "function": "Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.357", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.188", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.188", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" } ], "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0016491 oxidoreductase activity;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0102354 11-cis-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0042572 retinol metabolic process;GO:0007601 visual perception;GO:0110095 cellular detoxification of aldehyde", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P59837-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60902-1", "uniprot_id": [ { "id": "S10AA_BOVIN", "url": "https://www.uniprot.org/uniprot/P60902", "type": "external" } ], "mass": 11203.0, "length": 97, "protein_name": "Protein S100-A10", "gene_name": "S100A10", "organism": "Bovine", "refseq_name": "protein S100-A10", "refseq_ac": [ { "id": "NP_777075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777075", "type": "external" } ], "gene_names_uniprotkb": "S100A10; CAL1L; CLP11", "gene_names_refseq": "S100A10; p11", "protein_names_uniprotkb": "Protein S100-A10; Calpactin I light chain; Calpactin-1 light chain; Cellular ligand of annexin II; S100 calcium-binding protein A10; p10 protein; p11", "protein_names_refseq": "annexin II ligand, calpactin I, light polypeptide (p11); calpactin I light chain; calpactin-1 light chain; cellular ligand of annexin II; p10 protein; protein S100-A10", "tax_id": 9913, "disease": "", "pathway": " (bta:282466); (R-BTA-75205)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "2415974;2970844;3038891", "class_list": "", "function": "Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P08206;Q56JZ4", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:1990665 AnxA2-p11 complex", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0072659 protein localization to plasma membrane;GO:0051496 positive regulation of stress fiber assembly;GO:0051894 positive regulation of focal adhesion assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P60902-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P67868-1", "uniprot_id": [ { "id": "CSK2B_BOVIN", "url": "https://www.uniprot.org/uniprot/P67868", "type": "external" } ], "mass": 24942.0, "length": 215, "protein_name": "Casein kinase II subunit beta", "gene_name": "CSNK2B", "organism": "Bovine", "refseq_name": "casein kinase II subunit beta", "refseq_ac": [ { "id": "NP_001039919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039919", "type": "external" } ], "gene_names_uniprotkb": "CSNK2B; CK2N", "gene_names_refseq": "CSKN2B; CSNK2B", "protein_names_uniprotkb": "Casein kinase II subunit beta; CK II beta; Phosvitin", "protein_names_refseq": "CK II beta; Csnk2b-Ly6g5b; casein kinase 2, beta polypeptide; casein kinase II beta subunit; casein kinase II subunit beta; phosvitin", "tax_id": 9913, "disease": "", "pathway": " (bta:539235); (R-BTA-1483191); (R-BTA-201688); (R-BTA-2514853); (R-BTA-6798695); (R-BTA-6804756); (R-BTA-6814122); (R-BTA-8934903); (R-BTA-8939243); (R-BTA-8948751); (R-BTA-9768727); (R-BTA-9929491)", "pathway_count": 12, "publication_count": 3, "publication_id_list": "16977309;20016039;3299375", "class_list": "", "function": "CK2-activated phosphorylation cascade controlling PACS-1- and GGA3-mediated CI-MPR sorting, is reported., [RefSeq, PubMed]; Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity). Participates in Wnt signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data demonstrate that BoHV-1 VP22 interacts with both CK2 and US3, and that CK2 is the major kinase phosphorylating VP22, with US3 playing a minor role., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P07312;P13862;Q2YDL2", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0019887 protein kinase regulator activity;GO:0003682 chromatin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005956 protein kinase CK2 complex;GO:0005886 plasma membrane;GO:0001650 fibrillar center", "go_biological_process": "GO:0050792 regulation of viral process;GO:0016055 Wnt signaling pathway;GO:0042325 regulation of phosphorylation;GO:0046719 regulation by virus of viral protein levels in host cell;GO:0043537 negative regulation of blood vessel endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P67868-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P67983-1", "uniprot_id": [ { "id": "MT1A_BOVIN", "url": "https://www.uniprot.org/uniprot/P67983", "type": "external" } ], "mass": 5951.0, "length": 61, "protein_name": "Metallothionein-1A", "gene_name": "MT1A", "organism": "Bovine", "refseq_name": "metallothionein-1A", "refseq_ac": [ { "id": "NP_001035582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035582", "type": "external" } ], "gene_names_uniprotkb": "MT1A; MT-IA", "gene_names_refseq": "MT-1A; MT-IA; MT1A; MT1E; MTC", "protein_names_uniprotkb": "Metallothionein-1A; MT-1A; MT-IA; MTC; Metallothionein-IA", "protein_names_refseq": "metallothionein 1E; metallothionein-1A; metallothionein-IA", "tax_id": 9913, "disease": "", "pathway": " (bta:404071)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "3947100", "class_list": "", "function": "Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PK56;P04356;P04902", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071276 cellular response to cadmium ion;GO:0071280 cellular response to copper ion;GO:0010273 detoxification of copper ion;GO:0006882 intracellular zinc ion homeostasis;GO:0071294 cellular response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P67983-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68210-1", "uniprot_id": [ { "id": "ENSA_BOVIN", "url": "https://www.uniprot.org/uniprot/P68210", "type": "external" } ], "mass": 13361.0, "length": 121, "protein_name": "Alpha-endosulfine", "gene_name": "ENSA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSA", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-endosulfine; ARPP-19e", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281142)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8687439;9653196", "class_list": "", "function": "Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97976;Q2KID1;Q95105", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0051721 protein phosphatase 2A binding;GO:0019212 phosphatase inhibitor activity;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P68210-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68250-1", "uniprot_id": [ { "id": "1433B_BOVIN", "url": "https://www.uniprot.org/uniprot/P68250", "type": "external" } ], "mass": 28081.0, "length": 246, "protein_name": "14-3-3 protein beta/alpha", "gene_name": "YWHAB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "YWHAB", "gene_names_refseq": "", "protein_names_uniprotkb": "14-3-3 protein beta/alpha; KCIP-1; Protein kinase C inhibitor protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:286863)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1671102;7931346", "class_list": "", "function": "Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P29358;Q0VCL1", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0042470 melanosome", "go_biological_process": "GO:0007165 signal transduction;GO:0006605 protein targeting;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P68250-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68252-1", "uniprot_id": [ { "id": "1433G_BOVIN", "url": "https://www.uniprot.org/uniprot/P68252", "type": "external" } ], "mass": 28253.0, "length": 247, "protein_name": "14-3-3 protein gamma", "gene_name": "YWHAG", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "YWHAG", "gene_names_refseq": "", "protein_names_uniprotkb": "14-3-3 protein gamma; KCIP-1; Protein kinase C inhibitor protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1671102;7931346", "class_list": "", "function": "Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:7931346). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:7931346). Binding generally results in the modulation of the activity of the binding partner (PubMed:7931346). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (By similarity). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (By similarity). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes. Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P29359", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005080 protein kinase C binding;GO:0140031 phosphorylation-dependent protein binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0007165 signal transduction;GO:0048167 regulation of synaptic plasticity;GO:0032880 regulation of protein localization;GO:0045664 regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P68252-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68265-1", "uniprot_id": [ { "id": "GLTP_BOVIN", "url": "https://www.uniprot.org/uniprot/P68265", "type": "external" } ], "mass": 23922.0, "length": 209, "protein_name": "Glycolipid transfer protein", "gene_name": "GLTP", "organism": "Bovine", "refseq_name": "glycolipid transfer protein", "refseq_ac": [ { "id": "NP_786993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786993", "type": "external" } ], "gene_names_uniprotkb": "GLTP", "gene_names_refseq": "GLTP", "protein_names_uniprotkb": "Glycolipid transfer protein; GLTP", "protein_names_refseq": "glycolipid transfer protein", "tax_id": 9913, "disease": "", "pathway": " (bta:327678)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10671554;16309699;30550553", "class_list": "", "function": "Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides., [UniProtKB, PubMed, PubMed]; Results show that GLTP prefers shorter N-linked fully saturated acyl chain glucosylceramides, such as C8, C12, and C16, whereas long C18, C20, and C24-glucosylceramides are all bound more weakly and transported more slowly than their shorter counterparts; also indicate a break-point between C16- and C18-glucosylceramide in the GLTP sensing ability. Publication Status: Online-Only, [RefSeq, PubMed]; Three different X-ray structures of bovine GLTP at 1.4 angstroms, 1.6 angstroms and 1.8 angstroms resolution, all with a bound fatty acid or glycolipid, were solved., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17403;Q9MYP3", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:1902387 ceramide 1-phosphate binding;GO:1902388 ceramide 1-phosphate transfer activity;GO:0017089 glycolipid transfer activity;GO:0120013 lipid transfer activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0035627 ceramide transport;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P68265-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79099-1", "uniprot_id": [ { "id": "AQP2_BOVIN", "url": "https://www.uniprot.org/uniprot/P79099", "type": "external" } ], "mass": 28890.0, "length": 271, "protein_name": "Aquaporin-2", "gene_name": "AQP2", "organism": "Bovine", "refseq_name": "aquaporin-2", "refseq_ac": [ { "id": "NP_001094669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094669", "type": "external" } ], "gene_names_uniprotkb": "AQP2", "gene_names_refseq": "AQP2", "protein_names_uniprotkb": "Aquaporin-2; ADH water channel; AQP-2; AQP-CD; Aquaporin-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct", "protein_names_refseq": "ADH water channel; AQP-2; AQP-CD; WCH-CD; aquaporin 2 (collecting duct); aquaporin-2; aquaporin-CD; collecting duct water channel protein; water channel protein for renal collecting duct", "tax_id": 9913, "disease": "", "pathway": " (bta:539870); (R-BTA-432040); (R-BTA-432047)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9100366", "class_list": "", "function": "Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Could also be permeable to glycerol (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A7MBE5", "ec_number_list": [], "go_molecular_function": "GO:0015168 glycerol transmembrane transporter activity;GO:0015250 water channel activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome", "go_biological_process": "GO:0003091 renal water homeostasis;GO:0007015 actin filament organization;GO:0051289 protein homotetramerization;GO:0006833 water transport;GO:0071280 cellular response to copper ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P79099-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79100-1", "uniprot_id": [ { "id": "TRPC4_BOVIN", "url": "https://www.uniprot.org/uniprot/P79100", "type": "external" } ], "mass": 112287.0, "length": 979, "protein_name": "Short transient receptor potential channel 4", "gene_name": "TRPC4", "organism": "Bovine", "refseq_name": "short transient receptor potential channel 4", "refseq_ac": [ { "id": "NP_776903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776903", "type": "external" } ], "gene_names_uniprotkb": "TRPC4", "gene_names_refseq": "TRPC4", "protein_names_uniprotkb": "Short transient receptor potential channel 4; CCE1; Capacitative calcium entry channel 1; TrpC4", "protein_names_refseq": "CCE1; capacitative calcium entry channel 1; short transient receptor potential channel 4; transient receptor potential cation channel TRPC4 middle region 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282102); (R-BTA-3295583)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16818374;8947038;9498815", "class_list": "", "function": "Forms a receptor-activated non-selective calcium permeant cation channel (By similarity). Acts as a cell-cell contact-dependent endothelial calcium entry channel (By similarity). Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel (By similarity). Also permeable to monovalent ions including sodium, lithium and cesium ions (By similarity)., [UniProtKB, UniProtKB]; TRPC channel subunits 1 and 4 interact in bovine endothelial cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0046872 metal ion binding;GO:0015279 store-operated calcium channel activity;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:0070588 calcium ion transmembrane transport;GO:0003254 regulation of membrane depolarization;GO:0070509 calcium ion import", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P79100-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79101-1", "uniprot_id": [ { "id": "CPSF3_BOVIN", "url": "https://www.uniprot.org/uniprot/P79101", "type": "external" } ], "mass": 77488.0, "length": 684, "protein_name": "Cleavage and polyadenylation specificity factor subunit 3", "gene_name": "CPSF3", "organism": "Bovine", "refseq_name": "cleavage and polyadenylation specificity factor subunit 3", "refseq_ac": [ { "id": "NP_776709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776709", "type": "external" } ], "gene_names_uniprotkb": "CPSF3; CPSF73", "gene_names_refseq": "CPSF3", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 3; 3.1.27.-; CPSF 73 kDa subunit; Cleavage and polyadenylation specificity factor 73 kDa subunit; mRNA 3'-end-processing endonuclease CPSF-73", "protein_names_refseq": "CPSF 73 kDa subunit; cleavage and polyadenylation specific factor 3, 73kDa; cleavage and polyadenylation specificity factor 73 kDa subunit; cleavage and polyadenylation specificity factor subunit 3; mRNA 3'-end-processing endonuclease CPSF-73", "tax_id": 9913, "disease": "", "pathway": " (bta:281712); (R-BTA-159231); (R-BTA-73856); (R-BTA-77595); (R-BTA-9770562)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "8929409", "class_list": "", "function": "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as an mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for entering/progressing through S-phase of the cell cycle (By similarity). Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3MHX7", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity;GO:0004534 5'-3' RNA exonuclease activity", "go_cellular_component": "GO:1990904 ribonucleoprotein complex;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P79101-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79107-1", "uniprot_id": [ { "id": "FCG3A_BOVIN", "url": "https://www.uniprot.org/uniprot/P79107", "type": "external" } ], "mass": 28096.0, "length": 250, "protein_name": "Low affinity immunoglobulin gamma Fc region receptor III-A", "gene_name": "FCGR3A", "organism": "Bovine", "refseq_name": "low affinity immunoglobulin gamma Fc region receptor III-A isoform 1 precursor", "refseq_ac": [ { "id": "NP_001070870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070870", "type": "external" } ], "gene_names_uniprotkb": "FCGR3A; FCGR3; FCGRIII", "gene_names_refseq": "CD16; FCGR3@; FCGR3A; FCGR3", "protein_names_uniprotkb": "Low affinity immunoglobulin gamma Fc region receptor III-A; Fc-gamma RIII-alpha; FcgammaRIIIA; IgG Fc receptor III-A", "protein_names_refseq": "Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc gamma receptor III; Fc receptor, IgG, low affinity III; Fc-gamma RIII-alpha; IgG Fc receptor III-A; fc-gamma RIII; fcRIII; fcgammaRIIIA; igG Fc receptor III; low affinity immunoglobulin gamma Fc region receptor III-A isoform 1 precursor; low affinity immunoglobulin gamma Fc region receptor III-A; low affinity immunoglobulin gamma Fc region receptor III", "tax_id": 9913, "disease": "", "pathway": " (bta:281766); (R-BTA-163125); (R-BTA-6798695)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "18177938;9089104", "class_list": "", "function": "Cytotoxic role of lymph node residing NK cells, beyond the predominantly cytokine-producing role previously inferred from studies on human NK cells, [RefSeq, PubMed]; Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity). Fc-binding subunit that associates with FCER1G adapters to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F1N286;Q2KI63", "ec_number_list": [], "go_molecular_function": "GO:0019767 IgE receptor activity;GO:0019864 IgG binding;GO:0019770 IgG receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002468 dendritic cell antigen processing and presentation;GO:0007166 cell surface receptor signaling pathway;GO:0045780 positive regulation of bone resorption;GO:0042119 neutrophil activation;GO:0001788 antibody-dependent cellular cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P79107-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79121-1", "uniprot_id": [ { "id": "TIMP3_BOVIN", "url": "https://www.uniprot.org/uniprot/P79121", "type": "external" } ], "mass": 24197.0, "length": 211, "protein_name": "Metalloproteinase inhibitor 3", "gene_name": "TIMP3", "organism": "Bovine", "refseq_name": "metalloproteinase inhibitor 3 precursor", "refseq_ac": [ { "id": "NP_776898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776898", "type": "external" } ], "gene_names_uniprotkb": "TIMP3", "gene_names_refseq": "TIMP-3; TIMP3", "protein_names_uniprotkb": "Metalloproteinase inhibitor 3; TIMP-3; Tissue inhibitor of metalloproteinases 3", "protein_names_refseq": "TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory); metalloproteinase inhibitor 3 precursor; metalloproteinase inhibitor 3; tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); tissue inhibitor of metalloproteinases 3", "tax_id": 9913, "disease": "", "pathway": " (bta:282094)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11204721;15203191;17030988;17518631;8985117", "class_list": "", "function": "Mediates a variety of processes including matrix regulation and turnover, inflammation, and angiogenesis, through reversible inhibition of zinc protease superfamily enzymes, primarily matrix metalloproteinases (MMPs). Regulates extracellular matrix (ECM) remodeling through inhibition of matrix metalloproteinases (MMP) including MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Additionally, modulates the processing of amyloid precursor protein (APP) and apolipoprotein E receptor ApoER2 by inhibiting two alpha-secretases ADAM10 and ADAM17. Functions as a tumor suppressor and a potent inhibitor of angiogenesis. Exerts its anti-angiogenic effect by directly interacting with vascular endothelial growth factor (VEGF) receptor-2/KDR, preventing its binding to the VEGFA ligand. Selectively induces apoptosis in angiogenic endothelial cells through a caspase-independent cell death pathway. Mechanistically, inhibits matrix-induced focal adhesion kinase PTK2 tyrosine phosphorylation and association with paxillin/PXN and disrupts the incorporation of ITGB3, PTK2 and PXN into focal adhesion contacts on the matrix., [UniProtKB, UniProtKB, UniProtKB]; Reactive oxygen species mediate TGF-beta1-induced TIMP-3 gene expression, [RefSeq, PubMed]; TIMP3 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events., [RefSeq, PubMed]; TIMP3 mRNA expression level was upregulated by multidirectional articular motion., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2KIE9;Q9TVB2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0034097 response to cytokine;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P79121-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79255-1", "uniprot_id": [ { "id": "IL8_BOVIN", "url": "https://www.uniprot.org/uniprot/P79255", "type": "external" } ], "mass": 11291.0, "length": 101, "protein_name": "Interleukin-8", "gene_name": "CXCL8", "organism": "Bovine", "refseq_name": "interleukin-8 precursor", "refseq_ac": [ { "id": "NP_776350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776350", "type": "external" } ], "gene_names_uniprotkb": "CXCL8; IL8", "gene_names_refseq": "CXCL8; IL-8; IL8", "protein_names_uniprotkb": "Interleukin-8; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; IL-8", "protein_names_refseq": "C-X-C motif chemokine 8; chemokine (C-X-C motif) ligand 8; interleukin-8 precursor; interleukin-8; neutrophil activating peptide 1", "tax_id": 9913, "disease": "", "pathway": " (bta:280828); (R-BTA-375276); (R-BTA-380108); (R-BTA-418594)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "27863538;29101849;34182229;34214911;34246812;8737490", "class_list": "", "function": "Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways., [UniProtKB, UniProtKB]; Effect of IL-8 haplotype on temporal profile in circulating concentrations of interleukin 8 and 25(OH) vitamin D in Holstein-Friesian calves., [RefSeq, PubMed]; Effect of IL8 haplotype on immunological traits in periparturient dairy cows. Erratum:[Vet Immunol Immunopathol. 2023 Aug;262:110540. doi: 10.1016/j.vetimm.2022.110540. PMID: 36567172], [RefSeq, PubMed]; Genetic variation at the IL8 locus explains a proportion of the inter-breed and inter-individual variation in immunity between neonatal calves which is likely to influence their resistance to infection., [RefSeq, PubMed]; Molecular characterization of the bovine IER3 gene: Down-regulation of IL-8 by blocking NF-kappaB activity mediated by IER3 overexpression in MDBK cells infected with bovine viral diarrhea virus-1., [RefSeq, PubMed]; The immune response in bovine primary dermal fibroblasts is influenced by Interleukin 8 promoter haplotype and vitamin D., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9QWR1;Q3ZBG3;Q5MAD6", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005153 interleukin-8 receptor binding;GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:2000535 regulation of entry of bacterium into host cell;GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0006954 inflammatory response;GO:0030155 regulation of cell adhesion;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P79255-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79334-1", "uniprot_id": [ { "id": "PYGM_BOVIN", "url": "https://www.uniprot.org/uniprot/P79334", "type": "external" } ], "mass": 97293.0, "length": 842, "protein_name": "Glycogen phosphorylase, muscle form", "gene_name": "PYGM", "organism": "Bovine", "refseq_name": "glycogen phosphorylase, muscle form", "refseq_ac": [ { "id": "NP_786980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786980", "type": "external" } ], "gene_names_uniprotkb": "PYGM", "gene_names_refseq": "PYGM", "protein_names_uniprotkb": "Glycogen phosphorylase, muscle form; 2.4.1.1; Myophosphorylase", "protein_names_refseq": "glycogen phosphorylase, muscle form; muscle (McArdle syndrome, glycogen storage disease type V); myophosphorylase; phosphorylase, glycogen, muscle; phosphorylase, glycogen", "tax_id": 9913, "disease": "", "pathway": " (bta:327664)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "38678201;8845714", "class_list": "glycogene;glycosyltransferase", "function": "Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis., [UniProtKB, PubMed]; An autosomal recessive variant in PYGM causes myophosphorylase deficiency in Red Angus composite cattle. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0000166 nucleotide binding;GO:0008184 glycogen phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P79334-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79342-1", "uniprot_id": [ { "id": "S10AD_BOVIN", "url": "https://www.uniprot.org/uniprot/P79342", "type": "external" } ], "mass": 11199.0, "length": 98, "protein_name": "Protein S100-A13", "gene_name": "S100A13", "organism": "Bovine", "refseq_name": "protein S100-A13", "refseq_ac": [ { "id": "NP_991369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991369", "type": "external" } ], "gene_names_uniprotkb": "S100A13", "gene_names_refseq": "S100A13", "protein_names_uniprotkb": "Protein S100-A13; 8 kDa amlexanox-binding protein; S100 calcium-binding protein A13", "protein_names_refseq": "8KDa amlexanox-binding protein; protein S100-A13", "tax_id": 9913, "disease": "", "pathway": " (bta:404146)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBJ2", "ec_number_list": [], "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0015031 protein transport;GO:0001819 positive regulation of cytokine production;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043303 mast cell degranulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P79342-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79393-1", "uniprot_id": [ { "id": "PI2R_BOVIN", "url": "https://www.uniprot.org/uniprot/P79393", "type": "external" } ], "mass": 41247.0, "length": 385, "protein_name": "Prostacyclin receptor", "gene_name": "PTGIR", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTGIR", "gene_names_refseq": "", "protein_names_uniprotkb": "Prostacyclin receptor; PGI receptor; PGI2 receptor; Prostaglandin I2 receptor; Prostanoid IP receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016501 prostacyclin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0048662 negative regulation of smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P79393-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80209-1", "uniprot_id": [ { "id": "CATD_BOVIN", "url": "https://www.uniprot.org/uniprot/P80209", "type": "external" } ], "mass": 42491.0, "length": 390, "protein_name": "Cathepsin D", "gene_name": "CTSD", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CTSD", "gene_names_refseq": "", "protein_names_uniprotkb": "Cathepsin D; 3.4.23.5", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "8454061;8467789", "class_list": "", "function": "Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9TS27", "ec_number_list": [], "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0042470 melanosome", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P80209-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80513-1", "uniprot_id": [ { "id": "MANF_BOVIN", "url": "https://www.uniprot.org/uniprot/P80513", "type": "external" } ], "mass": 20357.0, "length": 179, "protein_name": "Mesencephalic astrocyte-derived neurotrophic factor", "gene_name": "MANF", "organism": "Bovine", "refseq_name": "mesencephalic astrocyte-derived neurotrophic factor precursor", "refseq_ac": [ { "id": "NP_001094681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094681", "type": "external" } ], "gene_names_uniprotkb": "MANF; ARMET; ARP", "gene_names_refseq": "ARMET; MANF", "protein_names_uniprotkb": "Mesencephalic astrocyte-derived neurotrophic factor; Arginine-rich protein; Protein ARMET", "protein_names_refseq": "arginine-rich protein; arginine-rich, mutated in early stage tumors; mesencephalic astrocyte-derived neurotrophic factor precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:540432); (R-BTA-114608)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17507765;8660651", "class_list": "", "function": "Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Stabilizes HSPA5/BiP in its substrate-bound ADP state, which facilitates HSPA5/BiP incorporation into chaperone-client complexes during endoplasmic reticulum stress, its interaction with HSPA5/BiP inhibits ATP binding to HSPA5/BiP and subsequent nucleotide exchange (By similarity). As a result acts as a repressor of the unfolded protein response (UPR) pathway (By similarity). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions. Essential for embryonic lung development (By similarity). Required for the correct postnatal temporal and structural development of splenic white pulp (By similarity). Required for the repair-associated myeloid response in skeletal muscle, acts as a regulator of phenotypic transition towards prorepair macrophages in response to muscle injury and as a result limits excessive proinflammatory signaling (By similarity). Represses RELA expression and therefore NF-kB signaling in the myocardium, as a result limits macrophage infiltration of injured tissue and M1 macrophage differentiation in response to myocardial injury (By similarity). Required for endochondral ossification in long bones and the skull during postnatal development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QPB9", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0033018 sarcoplasmic reticulum lumen", "go_biological_process": "GO:0031175 neuron projection development;GO:0006986 response to unfolded protein;GO:0071542 dopaminergic neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P80513-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80747-1", "uniprot_id": [ { "id": "ITB5_BOVIN", "url": "https://www.uniprot.org/uniprot/P80747", "type": "external" } ], "mass": 88057.0, "length": 800, "protein_name": "Integrin beta-5", "gene_name": "ITGB5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ITGB5", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrin beta-5", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9154926", "class_list": "", "function": "Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A3KMX2", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0008305 integrin complex;GO:0034684 integrin alphav-beta5 complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0007160 cell-matrix adhesion;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0033627 cell adhesion mediated by integrin", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P80747-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81019-1", "uniprot_id": [ { "id": "SFP4_BOVIN", "url": "https://www.uniprot.org/uniprot/P81019", "type": "external" } ], "mass": 21269.0, "length": 183, "protein_name": "Seminal plasma protein BSP-30 kDa", "gene_name": "", "organism": "Bovine", "refseq_name": "seminal plasma protein BSP-30 kDa precursor", "refseq_ac": [ { "id": "NP_777267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777267", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "BSP5; BSPH1", "protein_names_uniprotkb": "Seminal plasma protein BSP-30 kDa; BSP-30K", "protein_names_refseq": "BSP-30K; binder of sperm protein homolog 1; bovine seminal plasma protein-like 1; seminal plasma 30K protein; seminal plasma protein BSP-30 kDa precursor; seminal plasma protein BSP-30 kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:317699)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16790686;18207674;20331968;23740081;29100133;8980140", "class_list": "", "function": "BSP-30 plays a crucial role in fertilization by maintaining sperm motility during storage., [RefSeq, PubMed]; Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Displays heparin-, gelatin- and phospholipid-binding activities., [UniProtKB]; Data suggest that binding of BSP1, BSP3, and BSP5 is increased on surface of bull sperm following cryopreservation; binder of sperm proteins appear to play roles in formation of oviductal sperm storage reservoir and in sperm capacitation. Publication Status: Online-Only, [RefSeq, PubMed]; The binding of bovine seminal proteins A1, A2, and 30 kDa and osteopontin to spermatozoa and the effects of oviductal fluid on protein binding are reported., [RefSeq, PubMed]; The findings of the present study could establish the significance and association of BSP-5 proteins in sperm motility and how their level differ in semen from two different clinical groups of buffalo bulls; the study also demonstrated that the expression pattern of BSP-5 and other BSP variants in seminal plasma of bulls is species-specific., [RefSeq, PubMed]; This study provides the first experimental proof for the presence of intrinsically disordered N-terminal part in bovine BSP5., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 6, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O97868", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0033700 phospholipid efflux;GO:0007338 single fertilization;GO:0048240 sperm capacitation;GO:1902492 positive regulation of sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P81019-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81264-1", "uniprot_id": [ { "id": "PRRP_BOVIN", "url": "https://www.uniprot.org/uniprot/P81264", "type": "external" } ], "mass": 10544.0, "length": 98, "protein_name": "Prolactin-releasing peptide", "gene_name": "PRLH", "organism": "Bovine", "refseq_name": "prolactin-releasing peptide precursor", "refseq_ac": [ { "id": "NP_777215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777215", "type": "external" } ], "gene_names_uniprotkb": "PRLH; PRH", "gene_names_refseq": "PRH; PRLH; prRP", "protein_names_uniprotkb": "Prolactin-releasing peptide; PrRP; Prolactin-releasing hormone", "protein_names_refseq": "preproprolactin-releasing peptide; prolactin-releasing peptide precursor; prolactin-releasing peptide", "tax_id": 9913, "disease": "", "pathway": " (bta:286856)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "30079537;9607765", "class_list": "", "function": "Results indicate that variants of the PRLH and SOD1 genes are associated with heat tolerance in Chinese cattle., [RefSeq, PubMed]; Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031861 prolactin-releasing peptide receptor binding;GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007631 feeding behavior;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P81264-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82908-1", "uniprot_id": [ { "id": "KGD4_BOVIN", "url": "https://www.uniprot.org/uniprot/P82908", "type": "external" } ], "mass": 11543.0, "length": 103, "protein_name": "Alpha-ketoglutarate dehydrogenase component 4", "gene_name": "KGD4", "organism": "Bovine", "refseq_name": "alpha-ketoglutarate dehydrogenase component 4", "refseq_ac": [ { "id": "NP_001030515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030515", "type": "external" } ], "gene_names_uniprotkb": "KGD4; MRPS36", "gene_names_refseq": "KGD4; MRPS36", "protein_names_uniprotkb": "Alpha-ketoglutarate dehydrogenase component 4; Alpha-ketoglutarate dehydrogenase subunit 4; Mitochondrial ribosomal protein S36", "protein_names_refseq": "28S ribosomal protein S36, mitochondrial; MRP-S36; S36mt; alpha-ketoglutarate dehydrogenase component 4; alpha-ketoglutarate dehydrogenase subunit 4", "tax_id": 9913, "disease": "", "pathway": " (bta:613835); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-6783984); (R-BTA-9853506); (R-BTA-9937383)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "11279123;22015679;36854377", "class_list": "", "function": "Molecular adapter that is necessary to form a stable 2-oxoglutarate dehydrogenase enzyme complex (OGDHC). Enables the specific recruitment of E3 subunit to E2 subunit in the 2-oxoglutarate dehydrogenase complex (OGDHC)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYR1", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P82908-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85091-1", "uniprot_id": [ { "id": "CYFP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P85091", "type": "external" } ], "mass": 6047.0, "length": 51, "protein_name": "Cytoplasmic FMR1-interacting protein 1", "gene_name": "CYFIP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CYFIP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytoplasmic FMR1-interacting protein 1; Specifically Rac1-associated protein 1; Sra-1; p140sra-1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9417078", "class_list": "", "function": "Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding;GO:0030371 translation repressor activity", "go_cellular_component": "GO:0030027 lamellipodium;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm;GO:0043005 neuron projection;GO:0001726 ruffle", "go_biological_process": "GO:0030032 lamellipodium assembly;GO:0008360 regulation of cell shape;GO:0031529 ruffle organization;GO:0048675 axon extension", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P85091-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85521-1", "uniprot_id": [ { "id": "C163A_BOVIN", "url": "https://www.uniprot.org/uniprot/P85521", "type": "external" } ], "mass": 121806.0, "length": 1129, "protein_name": "Scavenger receptor cysteine-rich type 1 protein M130", "gene_name": "CD163", "organism": "Bovine", "refseq_name": "scavenger receptor cysteine-rich type 1 protein M130 precursor", "refseq_ac": [ { "id": "NP_001156885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156885", "type": "external" } ], "gene_names_uniprotkb": "CD163; M130", "gene_names_refseq": "CD163; M130", "protein_names_uniprotkb": "Scavenger receptor cysteine-rich type 1 protein M130", "protein_names_refseq": "scavenger receptor cysteine-rich type 1 protein M130 precursor; scavenger receptor cysteine-rich type 1 protein M130", "tax_id": 9913, "disease": "", "pathway": " (bta:533844); (R-BTA-2168880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "After shedding, the soluble form (sCD163) may play an anti-inflammatory role., [UniProtKB, UniProtKB]; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "C6KEM1", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P85521-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86435-1", "uniprot_id": [ { "id": "VGF_BOVIN", "url": "https://www.uniprot.org/uniprot/P86435", "type": "external" } ], "mass": 67620.0, "length": 618, "protein_name": "Neurosecretory protein VGF", "gene_name": "VGF", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "VGF", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurosecretory protein VGF; AQEE-30; VGF-derived peptide", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "17087818;7988466", "class_list": "", "function": "Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Also stimulates feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity)., [UniProtKB, UniProtKB]; Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons., [UniProtKB, UniProtKB]; Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030133 transport vesicle", "go_biological_process": "GO:0033500 carbohydrate homeostasis;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P86435-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86437-1", "uniprot_id": [ { "id": "CBLN1_BOVIN", "url": "https://www.uniprot.org/uniprot/P86437", "type": "external" } ], "mass": 21083.0, "length": 193, "protein_name": "Cerebellin-1", "gene_name": "CBLN1", "organism": "Bovine", "refseq_name": "cerebellin-1 precursor", "refseq_ac": [ { "id": "NP_001181981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181981", "type": "external" } ], "gene_names_uniprotkb": "CBLN1", "gene_names_refseq": "CBLN1", "protein_names_uniprotkb": "Cerebellin-1; Precerebellin", "protein_names_refseq": "cerebellin-1 precursor; precerebellin", "tax_id": 9913, "disease": "", "pathway": " (bta:618604)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (By similarity). Essential for long-term maintenance but not establishment of excitatory synapses (By similarity). Inhibits the formation and function of inhibitory GABAergic synapses in cerebellar Purkinje cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0045211 postsynaptic membrane;GO:0043083 synaptic cleft", "go_biological_process": "GO:0050808 synapse organization;GO:0099558 maintenance of synapse structure;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission;GO:0099550 trans-synaptic signaling, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P86437-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98133-1", "uniprot_id": [ { "id": "FBN1_BOVIN", "url": "https://www.uniprot.org/uniprot/P98133", "type": "external" } ], "mass": 312249.0, "length": 2871, "protein_name": "Fibrillin-1", "gene_name": "FBN1", "organism": "Bovine", "refseq_name": "fibrillin-1 precursor", "refseq_ac": [ { "id": "NP_776478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776478", "type": "external" } ], "gene_names_uniprotkb": "FBN1", "gene_names_refseq": "FBN1", "protein_names_uniprotkb": "Fibrillin-1; MP340", "protein_names_refseq": "MP340; fibrillin-1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281154); (R-BTA-1474228); (R-BTA-1566948); (R-BTA-2129379); (R-BTA-216083); (R-BTA-2173789); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "12560590;19393038;19524133;20686071;21989719;22221020;37167929;7835900;8557636", "class_list": "", "function": "Data suggest that genetic fibrillin-1 deficiency could alter normal endothelial signaling., [RefSeq, PubMed]; Developmental and hormonal regulation of FBN1 and OR4M1 mRNA in bovine granulosa cells., [RefSeq, PubMed]; Hormone that targets the liver to increase plasma glucose levels. Secreted by white adipose tissue and circulates in the plasma. Acts in response to fasting and promotes blood glucose elevation by binding to the surface of hepatocytes. Promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In cases of vascular calcification, the decreased expression of FBN1 may be partially responsible for decreased vascular elasticity and also for the decreased formation of new elastic fibers., [RefSeq, PubMed]; Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function. Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction plays an important role in the assembly of microfibrils., [UniProtKB, UniProtKB, UniProtKB]; Study concludes that the c.8227-1G>A mutation is causative for Marfan syndrome-like disease., [RefSeq, PubMed]; This is the first study to investigate the expression and localization of fibrillin proteins and latent TGF-beta binding proteins affecting TGFbeta bioavailability in the ovary., [RefSeq, PubMed]", "predicted_glycosites": 36, "predicted_n_glycosites": 15, "predicted_o_glycosites": 21, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 36, "binding_glycan_count": 0, "secondary_ac_list": "F1N4K8", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding;GO:0005179 hormone activity;GO:0005201 extracellular matrix structural constituent;GO:0005178 integrin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0001527 microfibril;GO:0005615 extracellular space;GO:0005604 basement membrane", "go_biological_process": "GO:0042593 glucose homeostasis;GO:0006006 glucose metabolic process;GO:0007507 heart development;GO:0033627 cell adhesion mediated by integrin;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P98133-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98140-1", "uniprot_id": [ { "id": "FA12_BOVIN", "url": "https://www.uniprot.org/uniprot/P98140", "type": "external" } ], "mass": 67160.0, "length": 612, "protein_name": "Coagulation factor XII", "gene_name": "F12", "organism": "Bovine", "refseq_name": "coagulation factor XII precursor", "refseq_ac": [ { "id": "NP_001068587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068587", "type": "external" } ], "gene_names_uniprotkb": "F12", "gene_names_refseq": "F12; HAF", "protein_names_uniprotkb": "Coagulation factor XII; 3.4.21.38; HAF; Hageman factor", "protein_names_refseq": "coagulation factor XII precursor; hageman factor", "tax_id": 9913, "disease": "", "pathway": " (bta:280789)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8186251;861210", "class_list": "", "function": "Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5I3", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005791 rough endoplasmic reticulum", "go_biological_process": "GO:0007596 blood coagulation;GO:0042730 fibrinolysis;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P98140-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00361-1", "uniprot_id": [ { "id": "ATP5I_BOVIN", "url": "https://www.uniprot.org/uniprot/Q00361", "type": "external" } ], "mass": 8321.0, "length": 71, "protein_name": "ATP synthase F(0) complex subunit e, mitochondrial", "gene_name": "ATP5ME", "organism": "Bovine", "refseq_name": "ATP synthase F(0) complex subunit e, mitochondrial", "refseq_ac": [ { "id": "NP_788812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788812", "type": "external" } ], "gene_names_uniprotkb": "ATP5ME; ATP5I", "gene_names_refseq": "ATP5I; ATP5ME", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit e, mitochondrial; ATP synthase membrane subunit e; ATPase subunit e", "protein_names_refseq": "ATP synthase F(0) complex subunit e, mitochondrial; ATP synthase subunit e, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E; ATP synthase, H+ transporting, mitochondrial Fo complex subunit E; ATPase subunit e", "tax_id": 9913, "disease": "", "pathway": " (bta:338040); (R-BTA-163210); (R-BTA-8949613)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "17570365;1827992;25851905", "class_list": "", "function": "Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0S4", "ec_number_list": [], "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q00361-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01361-1", "uniprot_id": [ { "id": "CP2DE_BOVIN", "url": "https://www.uniprot.org/uniprot/Q01361", "type": "external" } ], "mass": 56083.0, "length": 500, "protein_name": "Cytochrome P450 2D14", "gene_name": "CYP2D14", "organism": "Bovine", "refseq_name": "cytochrome P450 2D14", "refseq_ac": [ { "id": "NP_776954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776954", "type": "external" } ], "gene_names_uniprotkb": "CYP2D14", "gene_names_refseq": "CYP2D14; CYP2D6", "protein_names_uniprotkb": "Cytochrome P450 2D14; 1.14.14.1; CYPIID14", "protein_names_refseq": "CYPIID14; cytochrome P450 2D14; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6", "tax_id": 9913, "disease": "", "pathway": " (bta:282211); (R-BTA-211935); (R-BTA-211958); (R-BTA-211981); (R-BTA-211999); (R-BTA-9027307); (R-BTA-9749641)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "1396678", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q29454", "ec_number_list": [ { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q01361-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02368-1", "uniprot_id": [ { "id": "NDUB7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02368", "type": "external" } ], "mass": 16398.0, "length": 137, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7", "gene_name": "NDUFB7", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7", "refseq_ac": [ { "id": "NP_788833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788833", "type": "external" } ], "gene_names_uniprotkb": "NDUFB7", "gene_names_refseq": "NDUFB7", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; CI-B18; Complex I-B18; NADH-ubiquinone oxidoreductase B18 subunit", "protein_names_refseq": "CI-B18; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; NADH-ubiquinone oxidoreductase B18 subunit; complex I-B18", "tax_id": 9913, "disease": "", "pathway": " (bta:338065); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10852722;1518044;18721790;28100784", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0A1", "ec_number_list": [], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q02368-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02379-1", "uniprot_id": [ { "id": "NDUS5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02379", "type": "external" } ], "mass": 12668.0, "length": 106, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 5", "gene_name": "NDUFS5", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 5", "refseq_ac": [ { "id": "NP_788825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788825", "type": "external" } ], "gene_names_uniprotkb": "NDUFS5", "gene_names_refseq": "NDUFS5", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 5; CI-15 kDa; Complex I-15 kDa; NADH-ubiquinone oxidoreductase 15 kDa subunit", "protein_names_refseq": "CI-15 kDa; NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 5; NADH-ubiquinone oxidoreductase 15 kDa subunit; complex I-15 kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:338057); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10852722;1518044;18721790", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZC47", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02379-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03255-1", "uniprot_id": [ { "id": "SRY_BOVIN", "url": "https://www.uniprot.org/uniprot/Q03255", "type": "external" } ], "mass": 26627.0, "length": 229, "protein_name": "Sex-determining region Y protein", "gene_name": "SRY", "organism": "Bovine", "refseq_name": "sex-determining region Y protein", "refseq_ac": [ { "id": "NP_001014407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014407", "type": "external" } ], "gene_names_uniprotkb": "SRY; TDF", "gene_names_refseq": "SRY", "protein_names_uniprotkb": "Sex-determining region Y protein; Testis-determining factor", "protein_names_refseq": "sex determining factor Y; sex-determining region Y protein; sex-determining region of the Y-chromosome; testis-determining factor", "tax_id": 9913, "disease": "", "pathway": " (bta:280931)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15595696;18851760;20433524;32696344;7873883;8199324;8332478", "class_list": "", "function": "Analysis of mtDNA control region sequences and SRY gene sequences indicated more contribution to the Yunnan cattle from B. indicus than from B. taurus, [RefSeq, PubMed]; Heterologous expression, purification, and refolding of SRY protein: role of L-arginine as analyzed by simulation and practical study., [RefSeq, PubMed]; Mapped to the bovine Y chromosome (BTAY) by fluorescence in situ hybridization (FISH) and/or radiation hybrid (RH) mapping., [RefSeq, PubMed]; New insights into SRY regulation through identification of 5' conserved sequence are reported. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1XCJ6;A8WDV8", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007548 sex differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q03255-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04173-1", "uniprot_id": [ { "id": "GDS1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q04173", "type": "external" } ], "mass": 66449.0, "length": 608, "protein_name": "Rap1 GTPase-GDP dissociation stimulator 1", "gene_name": "RAP1GDS1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RAP1GDS1", "gene_names_refseq": "", "protein_names_uniprotkb": "Rap1 GTPase-GDP dissociation stimulator 1; Exchange factor smgGDS; SMG GDS protein; SMG P21 stimulatory GDP/GTP exchange protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "1495270;1901951;2118909", "class_list": "", "function": "Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA. Acts as a GEF for RHOC. Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases. Escorts RAC1 to the nucleus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP. Additionally, appears to chaperone the processing and/or trafficking of small GTPases containing a C-terminal polybasic region independently of GEF activity. Targets include RAP1A/RAP1B, RHOA, RHOB, RHOC, RAC1 and KRAS. Regulates mitochondrial dynamics by controlling RHOT function to promote mitochondrial fission during high calcium conditions. Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Acts as a GEF (guanine nucleotide exchange factor) for unprenylated RHOA. Chaperones the entry and passage of small GTPases through the prenylation pathway. Recognizes the last amino acid in the GTPase C-terminal CAAX motif with a preference for 'Leu' over 'Met', indicating involvement in the geranylgeranylation pathway. May also recognize prenylated GTPases., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A3Q1M477;Q9TS36", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005615 extracellular space", "go_biological_process": "GO:0034504 protein localization to nucleus;GO:0080120 CAAX-box protein maturation;GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration;GO:0010821 regulation of mitochondrion organization;GO:0051561 positive regulation of mitochondrial calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q04173-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B57-1", "uniprot_id": [ { "id": "OTU1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B57", "type": "external" } ], "mass": 38021.0, "length": 348, "protein_name": "Ubiquitin thioesterase OTU1", "gene_name": "YOD1", "organism": "Bovine", "refseq_name": "ubiquitin thioesterase OTU1", "refseq_ac": [ { "id": "NP_001073778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073778", "type": "external" } ], "gene_names_uniprotkb": "YOD1", "gene_names_refseq": "YOD1", "protein_names_uniprotkb": "Ubiquitin thioesterase OTU1; 3.4.19.12", "protein_names_refseq": "YOD1 OTU deubiquinating enzyme 1 homolog; ubiquitin thioesterase OTU1", "tax_id": 9913, "disease": "", "pathway": " (bta:539931); (R-BTA-5689896)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070536 protein K63-linked deubiquitination;GO:0016236 macroautophagy;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B57-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B62-1", "uniprot_id": [ { "id": "SNX1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B62", "type": "external" } ], "mass": 59056.0, "length": 522, "protein_name": "Sorting nexin-1", "gene_name": "SNX1", "organism": "Bovine", "refseq_name": "sorting nexin-1", "refseq_ac": [ { "id": "NP_001039572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039572", "type": "external" } ], "gene_names_uniprotkb": "SNX1", "gene_names_refseq": "SNX1", "protein_names_uniprotkb": "Sorting nexin-1", "protein_names_refseq": "sorting nexin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:512029)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1). Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0031901 early endosome membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0031623 receptor internalization;GO:0072673 lamellipodium morphogenesis;GO:0042147 retrograde transport, endosome to Golgi;GO:0034498 early endosome to Golgi transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B62-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B87-1", "uniprot_id": [ { "id": "FRDA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B87", "type": "external" } ], "mass": 23567.0, "length": 217, "protein_name": "Frataxin, mitochondrial", "gene_name": "FXN", "organism": "Bovine", "refseq_name": "frataxin, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001074196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074196", "type": "external" } ], "gene_names_uniprotkb": "FXN; FRDA", "gene_names_refseq": "FXN", "protein_names_uniprotkb": "Frataxin, mitochondrial; 1.16.3.1; Fxn", "protein_names_refseq": "frataxin, mitochondrial precursor; frataxin, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:505694); (R-BTA-1268020); (R-BTA-1362409); (R-BTA-9854311); (R-BTA-9865881)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as an activator of persulfide transfer to the scaffoding protein ISCU as component of the core iron-sulfur cluster (ISC) assembly complex and participates to the [2Fe-2S] cluster assembly. Accelerates sulfur transfer from NFS1 persulfide intermediate to ISCU and to small thiols such as L-cysteine and glutathione leading to persulfuration of these thiols and ultimately sulfide release. Binds ferrous ion and is released from FXN upon the addition of both L-cysteine and reduced FDX2 during [2Fe-2S] cluster assembly (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. May function as an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation. May play a role as a high affinity iron binding partner for FECH that is capable of both delivering iron to ferrochelatase and mediating the terminal step in mitochondrial heme biosynthesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Modulates the RNA-binding activity of ACO1. May be involved in the cytoplasmic iron-sulfur protein biogenesis. May contribute to oxidative stress resistance and overall cell survival., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "2.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.3", "type": "external" }, { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "7.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.8", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.3.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.5.1", "type": "external" }, { "id": "1.1.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0051537 2 iron, 2 sulfur cluster binding;GO:0008198 ferrous iron binding;GO:0004322 ferroxidase activity;GO:0034986 iron chaperone activity;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0099128 mitochondrial [2Fe-2S] assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0007005 mitochondrion organization;GO:0006783 heme biosynthetic process;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B87-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06283-1", "uniprot_id": [ { "id": "LYSC2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q06283", "type": "external" } ], "mass": 16304.0, "length": 147, "protein_name": "Lysozyme C-2", "gene_name": "LYZ2", "organism": "Bovine", "refseq_name": "lysozyme C-2 precursor", "refseq_ac": [ { "id": "NP_851342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851342", "type": "external" } ], "gene_names_uniprotkb": "LYZ2", "gene_names_refseq": "LYZ2; LYZF5", "protein_names_uniprotkb": "Lysozyme C-2; 1,4-beta-N-acetylmuramidase C; 3.2.1.17", "protein_names_refseq": "1,4-beta-N-acetylmuramidase C; lysozyme 2; lysozyme C-2 precursor; lysozyme F5", "tax_id": 9913, "disease": "", "pathway": " (bta:280849)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19348005;8308905", "class_list": "glycogene;glycosylhydrolase", "function": "Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0007586 digestion;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q06283-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06284-1", "uniprot_id": [ { "id": "LYSC3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q06284", "type": "external" } ], "mass": 16317.0, "length": 147, "protein_name": "Lysozyme C-3", "gene_name": "LYZ3", "organism": "Bovine", "refseq_name": "lysozyme C-3 precursor", "refseq_ac": [ { "id": "NP_776529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776529", "type": "external" } ], "gene_names_uniprotkb": "LYZ3", "gene_names_refseq": "LYZ3", "protein_names_uniprotkb": "Lysozyme C-3; 1,4-beta-N-acetylmuramidase C; 3.2.1.17", "protein_names_refseq": "1,4-beta-N-acetylmuramidase C; lysozyme C-3 precursor; lysozyme C-3", "tax_id": 9913, "disease": "", "pathway": " (bta:281289)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8308905", "class_list": "glycogene;glycosylhydrolase", "function": "Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0007586 digestion;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q06284-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06285-1", "uniprot_id": [ { "id": "LYSC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q06285", "type": "external" } ], "mass": 16279.0, "length": 147, "protein_name": "Lysozyme C-1", "gene_name": "LYZ1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LYZ1", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysozyme C-1; 1,4-beta-N-acetylmuramidase C; 3.2.1.17", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8308905", "class_list": "glycogene;glycosylhydrolase", "function": "Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0007586 digestion;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q06285-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06805-1", "uniprot_id": [ { "id": "TIE1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q06805", "type": "external" } ], "mass": 124953.0, "length": 1136, "protein_name": "Tyrosine-protein kinase receptor Tie-1", "gene_name": "TIE1", "organism": "Bovine", "refseq_name": "tyrosine-protein kinase receptor Tie-1 precursor", "refseq_ac": [ { "id": "NP_776390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776390", "type": "external" } ], "gene_names_uniprotkb": "TIE1; TIE-1; TIE", "gene_names_refseq": "TIE1; TIE", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor Tie-1; 2.7.10.1", "protein_names_refseq": "tyrosine kinase with immunoglobulin and epidermal growth factor homology domains; tyrosine-protein kinase receptor Tie-1 precursor; tyrosine-protein kinase receptor Tie-1", "tax_id": 9913, "disease": "", "pathway": " (bta:280941)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8415706", "class_list": "", "function": "Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0045766 positive regulation of angiogenesis;GO:0009888 tissue development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q06805-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06846-1", "uniprot_id": [ { "id": "RP3A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q06846", "type": "external" } ], "mass": 77978.0, "length": 704, "protein_name": "Rabphilin-3A", "gene_name": "RPH3A", "organism": "Bovine", "refseq_name": "rabphilin-3A", "refseq_ac": [ { "id": "NP_776879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776879", "type": "external" } ], "gene_names_uniprotkb": "RPH3A", "gene_names_refseq": "RPH3A", "protein_names_uniprotkb": "Rabphilin-3A; Exophilin-1", "protein_names_refseq": "exophilin-1; rabphilin 3A homolog; rabphilin-3A", "tax_id": 9913, "disease": "", "pathway": " (bta:282044)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "8262955;8384302;9450942", "class_list": "", "function": "Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (PubMed:9450942). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0031267 small GTPase binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0043197 dendritic spine;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045956 positive regulation of calcium ion-dependent exocytosis;GO:0099502 calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q06846-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07536-1", "uniprot_id": [ { "id": "MMSA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q07536", "type": "external" } ], "mass": 58063.0, "length": 537, "protein_name": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "gene_name": "ALDH6A1", "organism": "Bovine", "refseq_name": "methylmalonate-semialdehyde/malonate- semialdehyde dehydrogenase [acylating], mitochondrial precursor", "refseq_ac": [ { "id": "NP_787005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787005", "type": "external" } ], "gene_names_uniprotkb": "ALDH6A1; MMSDH", "gene_names_refseq": "ALDH6A1", "protein_names_uniprotkb": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial; 1.2.1.27; Aldehyde dehydrogenase family 6 member A1; MMSDH; Malonate-semialdehyde dehydrogenase [acylating]", "protein_names_refseq": "MMSDH; aldehyde dehydrogenase family 6 member A1; malonate-semialdehyde dehydrogenase; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; methylmalonate-semialdehyde/malonate- semialdehyde dehydrogenase [acylating], mitochondrial precursor; methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:327692)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8514806", "class_list": "", "function": "Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.27", "type": "external" } ], "go_molecular_function": "GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006210 thymine catabolic process;GO:0006574 L-valine catabolic process;GO:0006573 valine metabolic process;GO:0019859 thymine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q07536-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08D88-1", "uniprot_id": [ { "id": "NFIL3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08D88", "type": "external" } ], "mass": 51436.0, "length": 462, "protein_name": "Nuclear factor interleukin-3-regulated protein", "gene_name": "NFIL3", "organism": "Bovine", "refseq_name": "nuclear factor interleukin-3-regulated protein", "refseq_ac": [ { "id": "NP_001068708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068708", "type": "external" } ], "gene_names_uniprotkb": "NFIL3", "gene_names_refseq": "NFIL3", "protein_names_uniprotkb": "Nuclear factor interleukin-3-regulated protein", "protein_names_refseq": "nuclear factor interleukin-3-regulated protein", "tax_id": 9913, "disease": "", "pathway": " (bta:506097)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0006955 immune response;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08D88-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DI5-1", "uniprot_id": [ { "id": "RAP2C_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DI5", "type": "external" } ], "mass": 20745.0, "length": 183, "protein_name": "Ras-related protein Rap-2c", "gene_name": "RAP2C", "organism": "Bovine", "refseq_name": "ras-related protein Rap-2c", "refseq_ac": [ { "id": "NP_001069168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069168", "type": "external" } ], "gene_names_uniprotkb": "RAP2C", "gene_names_refseq": "RAP2C", "protein_names_uniprotkb": "Ras-related protein Rap-2c; 3.6.5.2", "protein_names_refseq": "ras-related protein Rap-2c", "tax_id": 9913, "disease": "", "pathway": " (bta:515181); (R-BTA-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0055038 recycling endosome membrane;GO:0044291 cell-cell contact zone", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0030336 negative regulation of cell migration;GO:0090557 establishment of endothelial intestinal barrier;GO:0061097 regulation of protein tyrosine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DI5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DI6-1", "uniprot_id": [ { "id": "RNF11_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DI6", "type": "external" } ], "mass": 17444.0, "length": 154, "protein_name": "RING finger protein 11", "gene_name": "RNF11", "organism": "Bovine", "refseq_name": "RING finger protein 11", "refseq_ac": [ { "id": "NP_001071421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071421", "type": "external" } ], "gene_names_uniprotkb": "RNF11", "gene_names_refseq": "RNF11; Sid1669", "protein_names_uniprotkb": "RING finger protein 11", "protein_names_refseq": "RING finger protein 11", "tax_id": 9913, "disease": "", "pathway": " (bta:522791)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22438830", "class_list": "", "function": "Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome (By similarity)., [UniProtKB]; We first demonstrate that a splice site variant in the RING finger protein 11 (RNF11) gene accounts for ~40% of cases of stunted growth in cattle, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0055037 recycling endosome;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08DI6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DI8-1", "uniprot_id": [ { "id": "PUS7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DI8", "type": "external" } ], "mass": 74594.0, "length": 659, "protein_name": "Pseudouridylate synthase 7 homolog", "gene_name": "PUS7", "organism": "Bovine", "refseq_name": "pseudouridylate synthase 7 homolog", "refseq_ac": [ { "id": "NP_001070407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070407", "type": "external" } ], "gene_names_uniprotkb": "PUS7", "gene_names_refseq": "PUS7", "protein_names_uniprotkb": "Pseudouridylate synthase 7 homolog; 5.4.99.-", "protein_names_refseq": "pseudouridylate synthase 7 (putative); pseudouridylate synthase 7 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:615644)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.99.25", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25", "type": "external" }, { "id": "5.4.99.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.12", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity;GO:0160150 tRNA pseudouridine(13) synthase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:1902036 regulation of hematopoietic stem cell differentiation;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DI8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DJ5-1", "uniprot_id": [ { "id": "CAD18_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DJ5", "type": "external" } ], "mass": 87801.0, "length": 790, "protein_name": "Cadherin-18", "gene_name": "CDH18", "organism": "Bovine", "refseq_name": "cadherin-18 precursor", "refseq_ac": [ { "id": "NP_001070305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070305", "type": "external" } ], "gene_names_uniprotkb": "CDH18", "gene_names_refseq": "CDH18", "protein_names_uniprotkb": "Cadherin-18", "protein_names_refseq": "cadherin 18, type 2; cadherin-18 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:512080); (R-BTA-418990)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0016342 catenin complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DJ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DM6-1", "uniprot_id": [ { "id": "SYNG1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DM6", "type": "external" } ], "mass": 28334.0, "length": 258, "protein_name": "Synapse differentiation-inducing gene protein 1", "gene_name": "SYNDIG1", "organism": "Bovine", "refseq_name": "synapse differentiation-inducing gene protein 1", "refseq_ac": [ { "id": "NP_001069731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069731", "type": "external" } ], "gene_names_uniprotkb": "SYNDIG1; TMEM90B", "gene_names_refseq": "DSPC2; SYNDIG1; TMEM90B", "protein_names_uniprotkb": "Synapse differentiation-inducing gene protein 1; DSPC2; Dispanin subfamily C member 2; SynDIG1; Transmembrane protein 90B", "protein_names_refseq": "dispanin subfamily C member 2; synapse differentiation-inducing gene protein 1; transmembrane protein 90B", "tax_id": 9913, "disease": "", "pathway": " (bta:541217)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22363774", "class_list": "", "function": "May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0035254 glutamate receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0043198 dendritic shaft;GO:0031901 early endosome membrane", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0006886 intracellular protein transport;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08DM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DR0-1", "uniprot_id": [ { "id": "PHF6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DR0", "type": "external" } ], "mass": 41289.0, "length": 365, "protein_name": "PHD finger protein 6", "gene_name": "PHF6", "organism": "Bovine", "refseq_name": "PHD finger protein 6", "refseq_ac": [ { "id": "NP_001069237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069237", "type": "external" } ], "gene_names_uniprotkb": "PHF6", "gene_names_refseq": "PHF6", "protein_names_uniprotkb": "PHD finger protein 6", "protein_names_refseq": "PHD finger protein 6", "tax_id": 9913, "disease": "", "pathway": " (bta:518186); (R-BTA-9940951)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000776 kinetochore", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DR0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DR9-1", "uniprot_id": [ { "id": "SPDLY_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DR9", "type": "external" } ], "mass": 69621.0, "length": 603, "protein_name": "Protein Spindly", "gene_name": "SPDL1", "organism": "Bovine", "refseq_name": "protein Spindly", "refseq_ac": [ { "id": "NP_001070322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070322", "type": "external" } ], "gene_names_uniprotkb": "SPDL1; CCDC99", "gene_names_refseq": "CCDC99; SPDL1", "protein_names_uniprotkb": "Protein Spindly; Coiled-coil domain-containing protein 99; Spindle apparatus coiled-coil domain-containing protein 1", "protein_names_refseq": "coiled-coil domain containing 99; coiled-coil domain-containing protein 99; protein Spindly; spindle apparatus coiled-coil domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:515158)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the localization of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Plays a role in cell migration (By similarity)., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043515 kinetochore binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0000940 outer kinetochore", "go_biological_process": "GO:0016477 cell migration;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0007080 mitotic metaphase chromosome alignment;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DR9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DU8-1", "uniprot_id": [ { "id": "BL1S6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DU8", "type": "external" } ], "mass": 19546.0, "length": 172, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 6", "gene_name": "BLOC1S6", "organism": "Bovine", "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 6", "refseq_ac": [ { "id": "NP_001069793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069793", "type": "external" } ], "gene_names_uniprotkb": "BLOC1S6; PA; PLDN", "gene_names_refseq": "BLOC1S6; PLDN", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 6; BLOC-1 subunit 6; Pallid protein homolog; Pallidin", "protein_names_refseq": "BLOC-1 subunit 6; biogenesis of lysosomal organelles complex-1, subunit 6, pallidin; biogenesis of lysosome-related organelles complex 1 subunit 6; pallid protein homolog; pallidin homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:614408); (R-BTA-432722)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16305752;19393038;19546860", "class_list": "", "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MY65", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005925 focal adhesion;GO:0016020 membrane;GO:0001725 stress fiber", "go_biological_process": "GO:0031175 neuron projection development;GO:0008089 anterograde axonal transport;GO:0035646 endosome to melanosome transport;GO:0048490 anterograde synaptic vesicle transport;GO:0032402 melanosome transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q08DU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DV5-1", "uniprot_id": [ { "id": "RN220_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DV5", "type": "external" } ], "mass": 62729.0, "length": 566, "protein_name": "E3 ubiquitin-protein ligase RNF220", "gene_name": "RNF220", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase RNF220", "refseq_ac": [ { "id": "NP_001070409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070409", "type": "external" } ], "gene_names_uniprotkb": "RNF220", "gene_names_refseq": "C1orf164; C3H1orf164; RNF220", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF220; 2.3.2.27; RING finger protein 220; RING-type E3 ubiquitin transferase RNF220", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF220; RING-type E3 ubiquitin transferase RNF220", "tax_id": 9913, "disease": "", "pathway": " (bta:616005)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8F6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination;GO:0060340 positive regulation of type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08DV5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DY9-1", "uniprot_id": [ { "id": "CASP3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DY9", "type": "external" } ], "mass": 31136.0, "length": 275, "protein_name": "Caspase-3", "gene_name": "CASP3", "organism": "Bovine", "refseq_name": "caspase-3", "refseq_ac": [ { "id": "NP_001071308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071308", "type": "external" } ], "gene_names_uniprotkb": "CASP3", "gene_names_refseq": "CASP3", "protein_names_uniprotkb": "Caspase-3; 3.4.22.56; CASP-3", "protein_names_refseq": "CASP-3; caspase 3, apoptosis-related cysteine peptidase; caspase-3", "tax_id": 9913, "disease": "", "pathway": " (bta:408016)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17393434;18272300;18277054;19654143;22829687;24962416", "class_list": "", "function": "Data suggest that Escherichia coli infections (here, administration of LPS) provokes luteolysis in diestrus, non-lactating cows and up-regulation of expression of caspase 3 in corpus luteum but has no effect on luteinization in the following cycle., [RefSeq, PubMed]; Data suggest that activation of caspase-3 is likely involved in both spontaneous and induced apoptosis in bovine pre-implantation embryos., [RefSeq, PubMed]; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively). Cleaves and inactivates interleukin-18 (IL18) (By similarity). Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Also involved in axon pruning during brain development (By similarity). Cleaves DSG2 in response to apoptosis resulting in a loss of full length DSG2 at desmosome cell junctions and subsequent loss of cell-cell adhesion (By similarity). Also cleaves JUP in response to apoptosis (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MRNA expression of Bax, Bcl-2, caspase-3 and-7 cannot be used as a reliable apoptosis detection method., [RefSeq, PubMed]; Over-expression of STC-1 up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism., [RefSeq, PubMed]; The capacity for blastocysts to undergo further development is related to degree of group II caspase activity, [RefSeq, PubMed]; Treatment of mammary epithelial cells with serotonin 1B and serotonin 2A receptor antagonists increased caspase-3 activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0008047 enzyme activator activity;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031264 death-inducing signaling complex", "go_biological_process": "GO:0006508 proteolysis;GO:1902004 positive regulation of amyloid-beta formation;GO:0006915 apoptotic process;GO:0030216 keratinocyte differentiation;GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q08DY9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DZ2-1", "uniprot_id": [ { "id": "PRP4K_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DZ2", "type": "external" } ], "mass": 116646.0, "length": 1008, "protein_name": "Serine/threonine-protein kinase PRP4 homolog", "gene_name": "PRP4K; PRPF4B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PRP4K; PRPF4B; PRPF4B", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase PRP4 homolog; 2.7.11.1; PRP4 pre-mRNA-processing factor 4 homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:512236)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation. Connects chromatin mediated regulation of transcription and pre-mRNA splicing. During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation. Associates and probably phosphorylates SMARCA4 and NCOR1. Phosphorylates SRSF1. Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores. Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13. Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0000776 kinetochore;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint;GO:0000387 spliceosomal snRNP assembly;GO:0045292 mRNA cis splicing, via spliceosome;GO:0046827 positive regulation of protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DZ2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E13-1", "uniprot_id": [ { "id": "RNF10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E13", "type": "external" } ], "mass": 89716.0, "length": 810, "protein_name": "E3 ubiquitin-protein ligase RNF10", "gene_name": "RNF10", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase RNF10", "refseq_ac": [ { "id": "NP_001070337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070337", "type": "external" } ], "gene_names_uniprotkb": "RNF10", "gene_names_refseq": "RNF10", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF10; 2.3.2.27; RING finger protein 10", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF10", "tax_id": 9913, "disease": "", "pathway": " (bta:520757)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling. Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC) or elongation. The ribosome quality control is activated in response to ribosome subunit imbalance, amino acid starvation or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR). RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3: monoubiquitinated RPS2/us5 and RPS3/us3 are then recognized by RIOK3 kinase, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit. The action of RNF10 in iRQC is counteracted by USP10., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H708", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0070651 nonfunctional rRNA decay;GO:0045893 positive regulation of DNA-templated transcription;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E13-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E25-1", "uniprot_id": [ { "id": "ZNT3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E25", "type": "external" } ], "mass": 41820.0, "length": 388, "protein_name": "Probable proton-coupled zinc antiporter SLC30A3", "gene_name": "SLC30A3", "organism": "Bovine", "refseq_name": "probable proton-coupled zinc antiporter SLC30A3", "refseq_ac": [ { "id": "NP_001070311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070311", "type": "external" } ], "gene_names_uniprotkb": "SLC30A3", "gene_names_refseq": "SLC30A3", "protein_names_uniprotkb": "Probable proton-coupled zinc antiporter SLC30A3; Solute carrier family 30 member 3; Zinc transporter 3; ZnT-3", "protein_names_refseq": "probable proton-coupled zinc antiporter SLC30A3; solute carrier family 30 (zinc transporter), member 3; zinc transporter 3; znT-3", "tax_id": 9913, "disease": "", "pathway": " (bta:512803)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable proton-coupled zinc ion antiporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046872 metal ion binding;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0010043 response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E25-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E26-1", "uniprot_id": [ { "id": "CRTC2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E26", "type": "external" } ], "mass": 72818.0, "length": 693, "protein_name": "CREB-regulated transcription coactivator 2", "gene_name": "CRTC2", "organism": "Bovine", "refseq_name": "CREB-regulated transcription coactivator 2", "refseq_ac": [ { "id": "NP_001069718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069718", "type": "external" } ], "gene_names_uniprotkb": "CRTC2; TORC2", "gene_names_refseq": "CRTC2", "protein_names_uniprotkb": "CREB-regulated transcription coactivator 2; TORC-2; Transducer of CREB protein 2; Transducer of regulated cAMP response element-binding protein 2", "protein_names_refseq": "CREB-regulated transcription coactivator 2; TORC-2; transducer of CREB protein 2; transducer of regulated cAMP response element-binding protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:540959)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31475823;32003022", "class_list": "", "function": "Bta-miR-149-5p inhibits proliferation and differentiation of bovine adipocytes through targeting CRTCs at both transcriptional and posttranscriptional levels., [RefSeq, PubMed]; Leucine and methionine stimulated CRTC2 but not p-CRTC2(Ser171) expression and nuclear localization in cow mammary epithelial cells., [RefSeq, PubMed]; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008140 cAMP response element binding protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051289 protein homotetramerization;GO:0071320 cellular response to cAMP;GO:0006094 gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08E26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E57-1", "uniprot_id": [ { "id": "BABA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E57", "type": "external" } ], "mass": 36886.0, "length": 332, "protein_name": "BRISC and BRCA1-A complex member 1", "gene_name": "BABAM1", "organism": "Bovine", "refseq_name": "BRISC and BRCA1-A complex member 1", "refseq_ac": [ { "id": "NP_001070269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070269", "type": "external" } ], "gene_names_uniprotkb": "BABAM1; MERIT40; NBA1", "gene_names_refseq": "BABAM1; C19orf62; C7H19orf62; MERIT40", "protein_names_uniprotkb": "BRISC and BRCA1-A complex member 1; Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex", "protein_names_refseq": "BRCA1-A complex subunit MERIT40; BRISC and BRCA1-A complex member 1; mediator of RAP80 interactions and targeting subunit of 40 kDa; new component of the BRCA1-A complex", "tax_id": 9913, "disease": "", "pathway": " (bta:504517); (R-BTA-5689901); (R-BTA-5693565); (R-BTA-5693571); (R-BTA-5693607); (R-BTA-69473)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070552 BRISC complex;GO:0016604 nuclear body;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0051301 cell division;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E57-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E62-1", "uniprot_id": [ { "id": "DDIT4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E62", "type": "external" } ], "mass": 24811.0, "length": 229, "protein_name": "DNA damage-inducible transcript 4 protein", "gene_name": "DDIT4", "organism": "Bovine", "refseq_name": "DNA damage-inducible transcript 4 protein", "refseq_ac": [ { "id": "NP_001069390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069390", "type": "external" } ], "gene_names_uniprotkb": "DDIT4", "gene_names_refseq": "DDIT4", "protein_names_uniprotkb": "DNA damage-inducible transcript 4 protein", "protein_names_refseq": "DNA damage-inducible transcript 4 protein", "tax_id": 9913, "disease": "", "pathway": " (bta:529235); (R-BTA-5628897)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes. Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0051607 defense response to virus;GO:0001666 response to hypoxia;GO:0001764 neuron migration;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E62-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09141-1", "uniprot_id": [ { "id": "CCL8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q09141", "type": "external" } ], "mass": 10900.0, "length": 99, "protein_name": "C-C motif chemokine 8", "gene_name": "CCL8", "organism": "Bovine", "refseq_name": "C-C motif chemokine 8 precursor", "refseq_ac": [ { "id": "NP_776432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776432", "type": "external" } ], "gene_names_uniprotkb": "CCL8; MCP2; SCYA8", "gene_names_refseq": "CCL8; SCYA8", "protein_names_uniprotkb": "C-C motif chemokine 8; MCP-2; Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; Small-inducible cytokine A8", "protein_names_refseq": "C-C motif chemokine 8 precursor; C-C motif chemokine 8-like; C-C motif chemokine 8; MCP-2; monocyte chemoattractant protein 2; small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2); small-inducible cytokine A8", "tax_id": 9913, "disease": "", "pathway": " (bta:281044)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8286035", "class_list": "", "function": "Chemotactic factor that attracts monocytes. This protein can bind heparin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJH3;Q95MD5", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0008201 heparin binding;GO:0016004 phospholipase activator activity;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0007267 cell-cell signaling;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q09141-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II59-1", "uniprot_id": [ { "id": "PDXK_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II59", "type": "external" } ], "mass": 34817.0, "length": 312, "protein_name": "Pyridoxal kinase", "gene_name": "PDXK", "organism": "Bovine", "refseq_name": "pyridoxal kinase", "refseq_ac": [ { "id": "NP_001069119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069119", "type": "external" } ], "gene_names_uniprotkb": "PDXK", "gene_names_refseq": "PDXK", "protein_names_uniprotkb": "Pyridoxal kinase; 2.7.1.35; Pyridoxine kinase", "protein_names_refseq": "pyridoxal (pyridoxine, vitamin B6) kinase; pyridoxal kinase; pyridoxine kinase", "tax_id": 9913, "disease": "", "pathway": " (bta:514168); (R-BTA-6798695); (R-BTA-964975)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (By similarity). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008478 pyridoxal kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009443 pyridoxal 5'-phosphate salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II59-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II86-1", "uniprot_id": [ { "id": "SNP29_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II86", "type": "external" } ], "mass": 28490.0, "length": 258, "protein_name": "Synaptosomal-associated protein 29", "gene_name": "SNAP29", "organism": "Bovine", "refseq_name": "synaptosomal-associated protein 29", "refseq_ac": [ { "id": "NP_001069427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069427", "type": "external" } ], "gene_names_uniprotkb": "SNAP29", "gene_names_refseq": "SNAP29", "protein_names_uniprotkb": "Synaptosomal-associated protein 29; SNAP-29; Soluble 29 kDa NSF attachment protein; Vesicle-membrane fusion protein SNAP-29", "protein_names_refseq": "SNAP-29; soluble 29 kDa NSF attachment protein; synaptosomal-associated protein 29; synaptosomal-associated protein, 29kDa; vesicle-membrane fusion protein SNAP-29", "tax_id": 9913, "disease": "", "pathway": " (bta:532261); (R-BTA-6798695); (R-BTA-6811438)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II86-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IID7-1", "uniprot_id": [ { "id": "DUS10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IID7", "type": "external" } ], "mass": 52389.0, "length": 482, "protein_name": "Dual specificity protein phosphatase 10", "gene_name": "DUSP10", "organism": "Bovine", "refseq_name": "dual specificity protein phosphatase 10", "refseq_ac": [ { "id": "NP_001029897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029897", "type": "external" } ], "gene_names_uniprotkb": "DUSP10", "gene_names_refseq": "DUSP10", "protein_names_uniprotkb": "Dual specificity protein phosphatase 10; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 10", "tax_id": 9913, "disease": "", "pathway": " (bta:541175); (R-BTA-112409); (R-BTA-5675221)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0048273 mitogen-activated protein kinase p38 binding;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0050680 negative regulation of epithelial cell proliferation;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0046329 negative regulation of JNK cascade;GO:1903753 negative regulation of p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IID7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIF9-1", "uniprot_id": [ { "id": "CP2U1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIF9", "type": "external" } ], "mass": 61997.0, "length": 543, "protein_name": "Cytochrome P450 2U1", "gene_name": "CYP2U1", "organism": "Bovine", "refseq_name": "cytochrome P450 2U1", "refseq_ac": [ { "id": "NP_001069518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069518", "type": "external" } ], "gene_names_uniprotkb": "CYP2U1", "gene_names_refseq": "CYP2U1", "protein_names_uniprotkb": "Cytochrome P450 2U1; 1.14.14.80; Long-chain fatty acid omega-monooxygenase", "protein_names_refseq": "cytochrome P450 2U1; cytochrome P450, family 2, subfamily U, polypeptide 1; long-chain fatty acid omega-monooxygenase", "tax_id": 9913, "disease": "", "pathway": " (bta:535227)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30336279", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin., [UniProtKB, UniProtKB]; This study shows that bta-miR-130a and bta-miR-130b play similar roles in the regulation of adipocyte differentiation in beef muscles by targeting the 3'UTR of PPARG and CYP2U1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008395 steroid hydroxylase activity;GO:0052869 arachidonate omega-hydroxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0008202 steroid metabolic process;GO:0006082 organic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0IIF9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIG6-1", "uniprot_id": [ { "id": "TRBP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIG6", "type": "external" } ], "mass": 38844.0, "length": 366, "protein_name": "RISC-loading complex subunit TARBP2", "gene_name": "TARBP2", "organism": "Bovine", "refseq_name": "RISC-loading complex subunit TARBP2", "refseq_ac": [ { "id": "NP_001069146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069146", "type": "external" } ], "gene_names_uniprotkb": "TARBP2", "gene_names_refseq": "TARBP2", "protein_names_uniprotkb": "RISC-loading complex subunit TARBP2", "protein_names_refseq": "RISC-loading complex subunit TARBP2; TAR (HIV-1) RNA binding protein 2; TARBP2, RISC loading complex RNA binding subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:514674); (R-BTA-203927); (R-BTA-426486); (R-BTA-9833482)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "11282978", "class_list": "", "function": "Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (By similarity). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (By similarity)., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003725 double-stranded RNA binding;GO:0035198 miRNA binding;GO:0035197 siRNA binding;GO:0070883 pre-miRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0016442 RISC complex;GO:0070578 RISC-loading complex", "go_biological_process": "GO:0050689 negative regulation of defense response to virus by host;GO:0070922 RISC complex assembly;GO:0006417 regulation of translation;GO:0031054 pre-miRNA processing;GO:0030422 siRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0IIG6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIH7-1", "uniprot_id": [ { "id": "ST14_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIH7", "type": "external" } ], "mass": 94964.0, "length": 855, "protein_name": "Suppressor of tumorigenicity 14 protein homolog", "gene_name": "ST14", "organism": "Bovine", "refseq_name": "suppressor of tumorigenicity 14 protein homolog", "refseq_ac": [ { "id": "NP_001070006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070006", "type": "external" } ], "gene_names_uniprotkb": "ST14; PRSS14", "gene_names_refseq": "ST14", "protein_names_uniprotkb": "Suppressor of tumorigenicity 14 protein homolog; 3.4.21.109; Serine protease 14", "protein_names_refseq": "serine protease 14; suppression of tumorigenicity 14 (colon carcinoma); suppressor of tumorigenicity 14 protein homolog; suppressor of tumorigenicity protein 14", "tax_id": 9913, "disease": "", "pathway": " (bta:767617)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (By similarity). Proteolytically cleaves and therefore activates TMPRSS13 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0016485 protein processing;GO:0030216 keratinocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIH7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0III3-1", "uniprot_id": [ { "id": "DC1I2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0III3", "type": "external" } ], "mass": 68377.0, "length": 612, "protein_name": "Cytoplasmic dynein 1 intermediate chain 2", "gene_name": "DYNC1I2", "organism": "Bovine", "refseq_name": "cytoplasmic dynein 1 intermediate chain 2", "refseq_ac": [ { "id": "NP_001069351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069351", "type": "external" } ], "gene_names_uniprotkb": "DYNC1I2", "gene_names_refseq": "DYNC1I2", "protein_names_uniprotkb": "Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; DH IC-2; Dynein intermediate chain 2, cytosolic", "protein_names_refseq": "DH IC-2; cytoplasmic dynein 1 intermediate chain 2; cytoplasmic dynein intermediate chain 2; dynein intermediate chain 2, cytosolic", "tax_id": 9913, "disease": "", "pathway": " (bta:526329)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11967380;34740731", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Copy number variation of bovine DYNC1I2 gene is associated with body conformation traits in chinese beef cattle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0031982 vesicle;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0010970 transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0III3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P570-1", "uniprot_id": [ { "id": "MVD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P570", "type": "external" } ], "mass": 43732.0, "length": 400, "protein_name": "Diphosphomevalonate decarboxylase", "gene_name": "MVD", "organism": "Bovine", "refseq_name": "diphosphomevalonate decarboxylase", "refseq_ac": [ { "id": "NP_001068892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068892", "type": "external" } ], "gene_names_uniprotkb": "MVD", "gene_names_refseq": "MVD", "protein_names_uniprotkb": "Diphosphomevalonate decarboxylase; 4.1.1.33; MDDase; Mevalonate (diphospho)decarboxylase; Mevalonate pyrophosphate decarboxylase", "protein_names_refseq": "MDDase; diphosphomevalonate decarboxylase; mevalonate (diphospho) decarboxylase; mevalonate pyrophosphate decarboxylase", "tax_id": 9913, "disease": "", "pathway": " (bta:509958); (R-BTA-446199); (R-BTA-9969896)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.33", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0030544 Hsp70 protein binding;GO:0004163 diphosphomevalonate decarboxylase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0006695 cholesterol biosynthetic process;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P570-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5B1-1", "uniprot_id": [ { "id": "PEX13_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5B1", "type": "external" } ], "mass": 44361.0, "length": 403, "protein_name": "Peroxisomal membrane protein PEX13", "gene_name": "PEX13", "organism": "Bovine", "refseq_name": "peroxisome biogenesis factor 13", "refseq_ac": [ { "id": "NP_001069680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069680", "type": "external" } ], "gene_names_uniprotkb": "PEX13", "gene_names_refseq": "PEX13", "protein_names_uniprotkb": "Peroxisomal membrane protein PEX13; Peroxin-13", "protein_names_refseq": "peroxin-13; peroxisomal membrane protein PEX13; peroxisome biogenesis factor 13", "tax_id": 9913, "disease": "", "pathway": " (bta:540337); (R-BTA-8866654); (R-BTA-9033241); (R-BTA-9603798)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Involved in the import of PTS1- and PTS2-type containing proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0016560 protein import into peroxisome matrix, docking", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5B1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5C2-1", "uniprot_id": [ { "id": "MTDC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5C2", "type": "external" } ], "mass": 37767.0, "length": 350, "protein_name": "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "gene_name": "MTHFD2", "organism": "Bovine", "refseq_name": "bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "refseq_ac": [ { "id": "NP_001069223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069223", "type": "external" } ], "gene_names_uniprotkb": "MTHFD2", "gene_names_refseq": "MTHFD2", "protein_names_uniprotkb": "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "protein_names_refseq": "bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase; methylenetetrahydrofolate dehydrogenase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:517539)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.9", "type": "external" }, { "id": "1.5.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.15", "type": "external" } ], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0000287 magnesium ion binding;GO:0004477 methenyltetrahydrofolate cyclohydrolase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0035999 tetrahydrofolate interconversion;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5C2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5C7-1", "uniprot_id": [ { "id": "HACD4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5C7", "type": "external" } ], "mass": 27559.0, "length": 231, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4", "gene_name": "HACD4", "organism": "Bovine", "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4", "refseq_ac": [ { "id": "NP_001069990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069990", "type": "external" } ], "gene_names_uniprotkb": "HACD4; PTPLAD2", "gene_names_refseq": "HACD4; PTPLAD2", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4; 3-hydroxyacyl-CoA dehydratase 4; 4.2.1.134; HACD4; Protein-tyrosine phosphatase-like A domain-containing protein 2", "protein_names_refseq": "protein tyrosine phosphatase-like A domain containing 2; protein tyrosine phosphatase-like protein PTPLAD2; protein-tyrosine phosphatase-like A domain-containing protein 2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 4", "tax_id": 9913, "disease": "", "pathway": " (bta:618814)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.134", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5C7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5D2-1", "uniprot_id": [ { "id": "CPSF6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5D2", "type": "external" } ], "mass": 59256.0, "length": 551, "protein_name": "Cleavage and polyadenylation specificity factor subunit 6", "gene_name": "CPSF6", "organism": "Bovine", "refseq_name": "cleavage and polyadenylation specificity factor subunit 6", "refseq_ac": [ { "id": "NP_001071574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071574", "type": "external" } ], "gene_names_uniprotkb": "CPSF6", "gene_names_refseq": "CPSF6", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 6", "protein_names_refseq": "cleavage and polyadenylation specific factor 6, 68 kD subunit; cleavage and polyadenylation specific factor 6, 68kDa; cleavage and polyadenylation specificity factor subunit 6", "tax_id": 9913, "disease": "", "pathway": " (bta:768231)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0043023 ribosomal large subunit binding;GO:1990448 exon-exon junction complex binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0046833 positive regulation of RNA export from nucleus;GO:0051290 protein heterotetramerization;GO:0110104 mRNA alternative polyadenylation;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5D2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5F7-1", "uniprot_id": [ { "id": "PI42C_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5F7", "type": "external" } ], "mass": 47142.0, "length": 421, "protein_name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "gene_name": "PIP4K2C", "organism": "Bovine", "refseq_name": "phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "refseq_ac": [ { "id": "NP_001069664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069664", "type": "external" } ], "gene_names_uniprotkb": "PIP4K2C; PIP5K2C", "gene_names_refseq": "PIP4K2C", "protein_names_uniprotkb": "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; 2.7.1.149; PI(5)P 4-kinase type II gamma; PIP4KII-gamma; Phosphatidylinositol 5-phosphate 4-kinase type II gamma", "protein_names_refseq": "PI(5)P 4-kinase type II gamma; PIP4KII-gamma; phosphatidylinositol 5-phosphate 4-kinase type II gamma; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "tax_id": 9913, "disease": "", "pathway": " (bta:540005); (R-BTA-1660499); (R-BTA-6811555); (R-BTA-6811558); (R-BTA-8847453)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0005524 ATP binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0010506 regulation of autophagy;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:1902635 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5F7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8B7-1", "uniprot_id": [ { "id": "MCM5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8B7", "type": "external" } ], "mass": 82146.0, "length": 734, "protein_name": "DNA replication licensing factor MCM5", "gene_name": "MCM5", "organism": "Bovine", "refseq_name": "DNA replication licensing factor MCM5", "refseq_ac": [ { "id": "NP_001068758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068758", "type": "external" } ], "gene_names_uniprotkb": "MCM5", "gene_names_refseq": "MCM5", "protein_names_uniprotkb": "DNA replication licensing factor MCM5; 3.6.4.12", "protein_names_refseq": "DNA replication licensing factor MCM5; minichromosome maintenance deficient protein 5", "tax_id": 9913, "disease": "", "pathway": " (bta:506970)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006270 DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8B7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8L2-1", "uniprot_id": [ { "id": "GGT7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8L2", "type": "external" } ], "mass": 70652.0, "length": 662, "protein_name": "Glutathione hydrolase 7", "gene_name": "GGT7", "organism": "Bovine", "refseq_name": "glutathione hydrolase 7", "refseq_ac": [ { "id": "NP_001069869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069869", "type": "external" } ], "gene_names_uniprotkb": "GGT7; GGTL3", "gene_names_refseq": "GGT7; GGTL3", "protein_names_uniprotkb": "Glutathione hydrolase 7; 2.3.2.2; 3.4.19.13; GGT 7; Gamma-glutamyltransferase 7; Gamma-glutamyltransferase-like 3; Gamma-glutamyltranspeptidase 7", "protein_names_refseq": "GGT 7; gamma-glutamyltransferase-like 3; gamma-glutamyltranspeptidase 7; glutathione hydrolase 7", "tax_id": 9913, "disease": "", "pathway": " (bta:615929); (R-BTA-174403); (R-BTA-5423646); (R-BTA-9753281)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A6QR42", "ec_number_list": [ { "id": "2.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.2", "type": "external" }, { "id": "3.4.19.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.13", "type": "external" }, { "id": "3.4.19.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.14", "type": "external" } ], "go_molecular_function": "GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0006751 glutathione catabolic process;GO:1902883 negative regulation of response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8L2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8L6-1", "uniprot_id": [ { "id": "PLD2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8L6", "type": "external" } ], "mass": 105766.0, "length": 933, "protein_name": "Phospholipase D2", "gene_name": "PLD2", "organism": "Bovine", "refseq_name": "phospholipase D2", "refseq_ac": [ { "id": "NP_001069295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069295", "type": "external" } ], "gene_names_uniprotkb": "PLD2", "gene_names_refseq": "PLD2", "protein_names_uniprotkb": "Phospholipase D2; 3.1.4.4; Choline phosphatase 2; PLD 2; Phosphatidylcholine-hydrolyzing phospholipase D2", "protein_names_refseq": "PLD 2; choline phosphatase 2; phosphatidylcholine-hydrolyzing phospholipase D2; phospholipase D2", "tax_id": 9913, "disease": "", "pathway": " (bta:522159)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16305752;20219982", "class_list": "", "function": "Function as phospholipase selective for phosphatidylcholine. May have a role in signal-induced cytoskeletal regulation and/or endocytosis., [UniProtKB, UniProtKB]; Results suggest that PLD2 is the isoform that mediates aldosterone secretion and likely priming., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08DV7", "ec_number_list": [ { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.1.4.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.39", "type": "external" } ], "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0009395 phospholipid catabolic process;GO:0060627 regulation of vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0V8L6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBZ5-1", "uniprot_id": [ { "id": "JUNB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VBZ5", "type": "external" } ], "mass": 35929.0, "length": 347, "protein_name": "Transcription factor JunB", "gene_name": "JUNB", "organism": "Bovine", "refseq_name": "transcription factor JunB", "refseq_ac": [ { "id": "NP_001069124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069124", "type": "external" } ], "gene_names_uniprotkb": "JUNB", "gene_names_refseq": "JUNB", "protein_names_uniprotkb": "Transcription factor JunB; Transcription factor AP-1 subunit JunB", "protein_names_refseq": "jun B proto-oncogene; transcription factor AP-1 subunit JunB; transcription factor JunB; transcription factor jun-B", "tax_id": 9913, "disease": "", "pathway": " (bta:514246)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18368600;32070024", "class_list": "", "function": "NCAPG Dynamically Coordinates the Myogenesis of Fetal Bovine Tissue by Adjusting Chromatin Accessibility. Publication Status: Online-Only, [RefSeq, PubMed]; The present data indicate that bovine dialyzable leukocyte extract can block the AP-1 DNA-binding activity and expression of several transcriptions factors in breast cancer cells., [RefSeq, PubMed]; Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3' (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0035976 transcription factor AP-1 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048545 response to steroid hormone;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VBZ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC16-1", "uniprot_id": [ { "id": "TGO1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC16", "type": "external" } ], "mass": 211668.0, "length": 1905, "protein_name": "Transport and Golgi organization protein 1 homolog", "gene_name": "MIA3", "organism": "Bovine", "refseq_name": "transport and Golgi organization protein 1 homolog precursor", "refseq_ac": [ { "id": "NP_001160043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160043", "type": "external" } ], "gene_names_uniprotkb": "MIA3", "gene_names_refseq": "MIA3", "protein_names_uniprotkb": "Transport and Golgi organization protein 1 homolog; TANGO1", "protein_names_refseq": "MIA family member 3, ER export factor; TANGO1; melanoma inhibitory activity family, member 3; melanoma inhibitory activity protein 3; transport and Golgi organization protein 1 homolog precursor; transport and Golgi organization protein 1 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:509133)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0048731 system development;GO:0090110 COPII-coated vesicle cargo loading;GO:0015031 protein transport;GO:0042953 lipoprotein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC16-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC20-1", "uniprot_id": [ { "id": "RXRG_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC20", "type": "external" } ], "mass": 50882.0, "length": 463, "protein_name": "Retinoic acid receptor RXR-gamma", "gene_name": "RXRG", "organism": "Bovine", "refseq_name": "retinoic acid receptor RXR-gamma", "refseq_ac": [ { "id": "NP_001068876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068876", "type": "external" } ], "gene_names_uniprotkb": "RXRG; NR2B3", "gene_names_refseq": "RXRG", "protein_names_uniprotkb": "Retinoic acid receptor RXR-gamma; Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma", "protein_names_refseq": "nuclear receptor subfamily 2 group B member 3; retinoic acid receptor RXR-gamma", "tax_id": 9913, "disease": "", "pathway": " (bta:509500); (R-BTA-383280); (R-BTA-5362517)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "18244925", "class_list": "", "function": "Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)., [UniProtKB]; Retinoic X receptor-gamma (RXRG) gene was studied as a candidate gene for the twinning trait of bovine., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0004879 nuclear receptor activity;GO:0044323 retinoic acid-responsive element binding;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048384 retinoic acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VC20-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC59-1", "uniprot_id": [ { "id": "NMNA2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC59", "type": "external" } ], "mass": 34468.0, "length": 307, "protein_name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2", "gene_name": "NMNAT2", "organism": "Bovine", "refseq_name": "nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2", "refseq_ac": [ { "id": "NP_001068954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068954", "type": "external" } ], "gene_names_uniprotkb": "NMNAT2", "gene_names_refseq": "NMNAT2", "protein_names_uniprotkb": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; 2.7.7.18; 2.7.7.1; NMN adenylyltransferase 2; NMN/NaMN adenylyltransferase 2; NaMN adenylyltransferase 2; Nicotinamide mononucleotide adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2", "protein_names_refseq": "NMN adenylyltransferase 2; NMN/NaMN adenylyltransferase 2; naMN adenylyltransferase 1; naMN adenylyltransferase 2; nicotinamide mononucleotide adenylyltransferase 2; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; nicotinate-nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:511042); (R-BTA-196807)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16 (By similarity). May be involved in the maintenance of axonal integrity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.1", "type": "external" }, { "id": "2.7.7.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004515 nicotinate-nucleotide adenylyltransferase activity;GO:0000309 nicotinamide-nucleotide adenylyltransferase activity;GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0030424 axon;GO:0030659 cytoplasmic vesicle membrane;GO:0005829 cytosol", "go_biological_process": "GO:0034355 NAD+ biosynthetic process via the salvage pathway;GO:0009435 NAD+ biosynthetic process;GO:0006741 NADP+ biosynthetic process;GO:2000766 negative regulation of cytoplasmic translation;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC59-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC73-1", "uniprot_id": [ { "id": "KTU_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC73", "type": "external" } ], "mass": 90970.0, "length": 829, "protein_name": "Protein kintoun", "gene_name": "DNAAF2", "organism": "Bovine", "refseq_name": "protein kintoun", "refseq_ac": [ { "id": "NP_001069492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069492", "type": "external" } ], "gene_names_uniprotkb": "DNAAF2; KTU", "gene_names_refseq": "C10H14orf104; C14orf104; DNAAF2; KTU", "protein_names_uniprotkb": "Protein kintoun; Dynein assembly factor 2, axonemal", "protein_names_refseq": "dynein assembly factor 2, axonemal; kintoun; protein kintoun", "tax_id": 9913, "disease": "", "pathway": " (bta:534465)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment., [UniProtKB, HAMAP]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0060285 cilium-dependent cell motility;GO:0070286 axonemal dynein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC73-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC82-1", "uniprot_id": [ { "id": "SPS1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC82", "type": "external" } ], "mass": 42881.0, "length": 392, "protein_name": "Selenide, water dikinase 1", "gene_name": "SEPHS1", "organism": "Bovine", "refseq_name": "selenide, water dikinase 1", "refseq_ac": [ { "id": "NP_001068784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068784", "type": "external" } ], "gene_names_uniprotkb": "SEPHS1", "gene_names_refseq": "SEPHS1", "protein_names_uniprotkb": "Selenide, water dikinase 1; 2.7.9.3; Selenium donor protein 1; Selenophosphate synthase 1", "protein_names_refseq": "selenide, water dikinase 1; selenium donor protein 1; selenophosphate synthase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:507470)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression. The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif. Within the complex, SEPHS1, recognizes and binds the backbone of zinc fingers of transcription factors in a sequence-independent manner via its arginine clamp, enhancing their DNA-binding stability. Plays an essential role in redox homeostasis. May also be involved in selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP. Its role in selenocysteine biosynthesis is however unclear and several studies suggest that it does not act as a selenophosphate synthase in vivo or plays an non-essential role. Required for cardiac differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.9.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.9.3", "type": "external" } ], "go_molecular_function": "GO:0004756 selenide, water dikinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005694 chromosome", "go_biological_process": "GO:0016260 selenocysteine biosynthetic process;GO:0006351 DNA-templated transcription;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC82-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC84-1", "uniprot_id": [ { "id": "C1GLT_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC84", "type": "external" } ], "mass": 43041.0, "length": 368, "protein_name": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1", "gene_name": "C1GALT1", "organism": "Bovine", "refseq_name": "glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1", "refseq_ac": [ { "id": "NP_001069628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069628", "type": "external" } ], "gene_names_uniprotkb": "C1GALT1", "gene_names_refseq": "C1GALT1", "protein_names_uniprotkb": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; 2.4.1.122; C1GalT1; Core 1 O-glycan T-synthase; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; Core 1 beta1,3-galactosyltransferase 1; Core 1 beta3-Gal-T1", "protein_names_refseq": "core 1 O-glycan T-synthase; core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; core 1 beta1,3-galactosyltransferase 1; core 1 beta3-Gal-T1; core 1 beta3-Gal-T; core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:539417); (R-BTA-913709)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins (By similarity). Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.122", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0001822 kidney development", "synthesized_glycan_count": 3300, "hit_score": 0.1, "record_id": "Q0VC84-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCA7-1", "uniprot_id": [ { "id": "OXSM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCA7", "type": "external" } ], "mass": 48617.0, "length": 460, "protein_name": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial", "gene_name": "OXSM", "organism": "Bovine", "refseq_name": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001069092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069092", "type": "external" } ], "gene_names_uniprotkb": "OXSM", "gene_names_refseq": "OXSM", "protein_names_uniprotkb": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; 2.3.1.41; Beta-ketoacyl-ACP synthase", "protein_names_refseq": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor; 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; beta-ketoacyl-ACP synthase", "tax_id": 9913, "disease": "", "pathway": " (bta:513530)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" } ], "go_molecular_function": "GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCA7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCD2-1", "uniprot_id": [ { "id": "TBG1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCD2", "type": "external" } ], "mass": 51148.0, "length": 451, "protein_name": "Tubulin gamma-1 chain", "gene_name": "TUBG1", "organism": "Bovine", "refseq_name": "tubulin gamma-1 chain", "refseq_ac": [ { "id": "NP_001069723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069723", "type": "external" } ], "gene_names_uniprotkb": "TUBG1", "gene_names_refseq": "TUBG1", "protein_names_uniprotkb": "Tubulin gamma-1 chain; Gamma-1-tubulin", "protein_names_refseq": "gamma-1-tubulin; tubulin gamma-1 chain", "tax_id": 9913, "disease": "", "pathway": " (bta:541101); (R-BTA-2565942); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-8854518)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "18753210", "class_list": "", "function": "Authors report that the only viral nonstructural protein able to reproduce the loss of gamma-tubulin from the microtubule organizing center and the loss of integrity of the microtubule system is Foot-and-mouth disease virus 3C(pro)., [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (By similarity). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (By similarity). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (By similarity). Plays a role in sperm morphological development during late stage spermiogenesis, particularly the anchoring of the sperm head to the tail (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0140490 microtubule nucleator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:1990498 mitotic spindle microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007020 microtubule nucleation;GO:0007052 mitotic spindle organization;GO:0000070 mitotic sister chromatid segregation;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VCD2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCI6-1", "uniprot_id": [ { "id": "PIHD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCI6", "type": "external" } ], "mass": 32415.0, "length": 290, "protein_name": "PIH1 domain-containing protein 1", "gene_name": "PIH1D1", "organism": "Bovine", "refseq_name": "PIH1 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001068863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068863", "type": "external" } ], "gene_names_uniprotkb": "PIH1D1", "gene_names_refseq": "PIH1D1", "protein_names_uniprotkb": "PIH1 domain-containing protein 1", "protein_names_refseq": "PIH1 domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:509212)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006364 rRNA processing;GO:0000492 box C/D snoRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCI6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCJ2-1", "uniprot_id": [ { "id": "MTNB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCJ2", "type": "external" } ], "mass": 27095.0, "length": 242, "protein_name": "Methylthioribulose-1-phosphate dehydratase", "gene_name": "APIP", "organism": "Bovine", "refseq_name": "methylthioribulose-1-phosphate dehydratase", "refseq_ac": [ { "id": "NP_001068820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068820", "type": "external" } ], "gene_names_uniprotkb": "APIP", "gene_names_refseq": "APIP", "protein_names_uniprotkb": "Methylthioribulose-1-phosphate dehydratase; 4.2.1.109; APAF1-interacting protein; MTRu-1-P dehydratase", "protein_names_refseq": "MTRu-1-P dehydratase; methylthioribulose-1-phosphate dehydratase; probable methylthioribulose-1-phosphate dehydratase", "tax_id": 9913, "disease": "", "pathway": " (bta:508345); (R-BTA-111458); (R-BTA-9627069)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "4.2.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.109", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0046570 methylthioribulose 1-phosphate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0051289 protein homotetramerization;GO:0006915 apoptotic process;GO:0070269 pyroptotic inflammatory response;GO:0070372 regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCJ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCK5-1", "uniprot_id": [ { "id": "AP2A2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCK5", "type": "external" } ], "mass": 103769.0, "length": 938, "protein_name": "AP-2 complex subunit alpha-2", "gene_name": "AP2A1; AP2A2", "organism": "Bovine", "refseq_name": "AP-2 complex subunit alpha-2", "refseq_ac": [ { "id": "NP_001069170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069170", "type": "external" } ], "gene_names_uniprotkb": "AP2A1; AP2A2; AP2A1", "gene_names_refseq": "AP2A2", "protein_names_uniprotkb": "AP-2 complex subunit alpha-2; 100 kDa coated vesicle protein C; Adaptor protein complex AP-2 subunit alpha-2; Adaptor-related protein complex 2 subunit alpha-2; Alpha-adaptin C; Alpha2-adaptin; Clathrin assembly protein complex 2 alpha-C large chain; Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit", "protein_names_refseq": "100 kDa coated vesicle protein C; AP-2 complex subunit alpha-2; adapter-related protein complex 2 alpha-2 subunit; adapter-related protein complex 2 subunit alpha-2; adaptor protein complex AP-2 subunit alpha-2; adaptor related protein complex 2 alpha 2 subunit; alpha-adaptin C; alpha2-adaptin; clathrin assembly protein complex 2 alpha-C large chain; plasma membrane adaptor HA2/AP2 adaptin alpha C subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:515216); (R-BTA-177504); (R-BTA-2132295); (R-BTA-416993); (R-BTA-437239); (R-BTA-5099900); (R-BTA-5140745); (R-BTA-6798695); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-8866427); (R-BTA-8964038)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "2564002", "class_list": "", "function": "Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0008289 lipid binding;GO:0097718 disordered domain specific binding;GO:0035615 clathrin adaptor activity;GO:0050750 low-density lipoprotein particle receptor binding", "go_cellular_component": "GO:0030122 AP-2 adaptor complex;GO:0098793 presynapse;GO:0098978 glutamatergic synapse;GO:0032433 filopodium tip;GO:0098843 postsynaptic endocytic zone", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0048488 synaptic vesicle endocytosis;GO:1900126 negative regulation of hyaluronan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VCK5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCN3-1", "uniprot_id": [ { "id": "IFT27_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCN3", "type": "external" } ], "mass": 20646.0, "length": 186, "protein_name": "Intraflagellar transport protein 27 homolog", "gene_name": "IFT27", "organism": "Bovine", "refseq_name": "intraflagellar transport protein 27 homolog", "refseq_ac": [ { "id": "NP_001069913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069913", "type": "external" } ], "gene_names_uniprotkb": "IFT27; RABL4; RAYL", "gene_names_refseq": "IFT27; RABL4", "protein_names_uniprotkb": "Intraflagellar transport protein 27 homolog; IFT27; Putative GTP-binding protein RAY-like; Rab-like protein 4", "protein_names_refseq": "RAB, member of RAS oncogene family-like 4; intraflagellar transport 27 homolog; intraflagellar transport protein 27 homolog; rab-like protein 4", "tax_id": 9913, "disease": "", "pathway": " (bta:617147); (R-BTA-5620924)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6X3", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005929 cilium;GO:0036126 sperm flagellum", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0001822 kidney development;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCN3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCP4-1", "uniprot_id": [ { "id": "SEPT8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCP4", "type": "external" } ], "mass": 51250.0, "length": 442, "protein_name": "Septin-8", "gene_name": "SEPTIN8", "organism": "Bovine", "refseq_name": "septin-8", "refseq_ac": [ { "id": "NP_001069698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069698", "type": "external" } ], "gene_names_uniprotkb": "SEPTIN8; SEPT8", "gene_names_refseq": "SEPT8; SEPTIN8", "protein_names_uniprotkb": "Septin-8", "protein_names_refseq": "septin-8", "tax_id": 9913, "disease": "", "pathway": " (bta:540614)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (By similarity). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0030424 axon;GO:0015630 microtubule cytoskeleton;GO:0030672 synaptic vesicle membrane;GO:0098793 presynapse", "go_biological_process": "GO:0035542 regulation of SNARE complex assembly;GO:0031647 regulation of protein stability;GO:0008104 intracellular protein localization;GO:0033157 regulation of intracellular protein transport;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCP4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCQ0-1", "uniprot_id": [ { "id": "CPTP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCQ0", "type": "external" } ], "mass": 24574.0, "length": 214, "protein_name": "Ceramide-1-phosphate transfer protein", "gene_name": "CPTP", "organism": "Bovine", "refseq_name": "ceramide-1-phosphate transfer protein", "refseq_ac": [ { "id": "NP_001068650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068650", "type": "external" } ], "gene_names_uniprotkb": "CPTP; GLTPD1", "gene_names_refseq": "CPTP; GLTPD1", "protein_names_uniprotkb": "Ceramide-1-phosphate transfer protein; CPTP; Glycolipid transfer protein domain-containing protein 1", "protein_names_refseq": "ceramide-1-phosphate transfer protein; glycolipid transfer protein domain containing 1; glycolipid transfer protein domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:505009); (R-BTA-9845576)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles. Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:1902387 ceramide 1-phosphate binding;GO:1902388 ceramide 1-phosphate transfer activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0035627 ceramide transport;GO:0032691 negative regulation of interleukin-1 beta production;GO:0010507 negative regulation of autophagy;GO:1902389 ceramide 1-phosphate transport;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCQ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCR7-1", "uniprot_id": [ { "id": "C1TM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCR7", "type": "external" } ], "mass": 105227.0, "length": 975, "protein_name": "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "gene_name": "MTHFD1L", "organism": "Bovine", "refseq_name": "monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001069486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069486", "type": "external" } ], "gene_names_uniprotkb": "MTHFD1L", "gene_names_refseq": "MTHFD1L", "protein_names_uniprotkb": "Monofunctional C1-tetrahydrofolate synthase, mitochondrial; 6.3.4.3; Formyltetrahydrofolate synthetase", "protein_names_refseq": "formyltetrahydrofolate synthetase; monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor; monofunctional C1-tetrahydrofolate synthase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:534296); (R-BTA-196757)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6QNK9", "ec_number_list": [ { "id": "6.3.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004329 formate-tetrahydrofolate ligase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0009257 10-formyltetrahydrofolate biosynthetic process;GO:0015942 formate metabolic process;GO:0035999 tetrahydrofolate interconversion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCR7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCT9-1", "uniprot_id": [ { "id": "CITE2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCT9", "type": "external" } ], "mass": 28710.0, "length": 273, "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "organism": "Bovine", "refseq_name": "cbp/p300-interacting transactivator 2", "refseq_ac": [ { "id": "NP_001069287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069287", "type": "external" } ], "gene_names_uniprotkb": "CITED2", "gene_names_refseq": "CITED2", "protein_names_uniprotkb": "Cbp/p300-interacting transactivator 2", "protein_names_refseq": "cbp/p300-interacting transactivator 2", "tax_id": 9913, "disease": "", "pathway": " (bta:521378); (R-BTA-1234158); (R-BTA-8866907)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Also acts as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050693 LBD domain binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0003156 regulation of animal organ formation;GO:0007530 sex determination;GO:0022409 positive regulation of cell-cell adhesion;GO:0035802 adrenal cortex formation;GO:0060971 embryonic heart tube left/right pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCT9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCW4-1", "uniprot_id": [ { "id": "SDHL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCW4", "type": "external" } ], "mass": 34441.0, "length": 327, "protein_name": "L-serine dehydratase/L-threonine deaminase", "gene_name": "SDS", "organism": "Bovine", "refseq_name": "L-serine dehydratase/L-threonine deaminase", "refseq_ac": [ { "id": "NP_001069130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069130", "type": "external" } ], "gene_names_uniprotkb": "SDS; SDH", "gene_names_refseq": "SDS", "protein_names_uniprotkb": "L-serine dehydratase/L-threonine deaminase; 4.3.1.17; 4.3.1.19; L-serine deaminase; L-threonine dehydratase; SDH; TDH", "protein_names_refseq": "L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; SDH; TDH", "tax_id": 9913, "disease": "", "pathway": " (bta:514346)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the pyridoxal-phosphate-dependent dehydrative deamination of L-threonine and L-serine to ammonia and alpha-ketobutyrate and pyruvate, respectively., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.17", "type": "external" }, { "id": "4.3.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.18", "type": "external" }, { "id": "5.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.1.18", "type": "external" }, { "id": "4.3.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.19", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0003941 L-serine ammonia-lyase activity;GO:0004794 threonine deaminase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:0006629 lipid metabolic process;GO:0006094 gluconeogenesis;GO:0006567 L-threonine catabolic process;GO:0006565 L-serine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCW4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCX1-1", "uniprot_id": [ { "id": "C1S_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCX1", "type": "external" } ], "mass": 76609.0, "length": 689, "protein_name": "Complement C1s subcomponent", "gene_name": "C1S", "organism": "Bovine", "refseq_name": "complement C1s subcomponent precursor", "refseq_ac": [ { "id": "NP_001070018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070018", "type": "external" } ], "gene_names_uniprotkb": "C1S", "gene_names_refseq": "C1S", "protein_names_uniprotkb": "Complement C1s subcomponent; 3.4.21.42; C1 esterase; Complement component 1 subcomponent s", "protein_names_refseq": "C1 esterase; complement C1s subcomponent precursor; complement C1s subcomponent; complement component 1 subcomponent s; complement component 1, s subcomponent", "tax_id": 9913, "disease": "", "pathway": " (bta:767827)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains. C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway., [UniProtKB, UniProtKB]; Serine protease component of the complement C1 complex, which catalyzes cleavage and activation of C2 and C4, the next components of the classical complement pathway. Also cleaves IGFBP5 and thereby inhibits the trophic effects of IGF1., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCX1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q148D5-1", "uniprot_id": [ { "id": "SUCB1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q148D5", "type": "external" } ], "mass": 50130.0, "length": 463, "protein_name": "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "gene_name": "SUCLA2", "organism": "Bovine", "refseq_name": "succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "refseq_ac": [ { "id": "NP_001068961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068961", "type": "external" } ], "gene_names_uniprotkb": "SUCLA2", "gene_names_refseq": "A-SCS; SUCLA2", "protein_names_uniprotkb": "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; 6.2.1.-; 6.2.1.5; 6.2.1.9; A-SCS; ATP-specific succinyl-CoA synthetase subunit beta; Itaconyl--CoA ligase [ADP-forming] subunit beta; Malyl--CoA ligase [ADP-forming] subunit beta; SCS-betaA; Succinyl-CoA synthetase beta-A chain", "protein_names_refseq": "ATP-specific succinyl-CoA synthetase subunit beta; SCS-betaA; itaconyl--CoA ligase [ADP-forming] subunit beta; malyl--CoA ligase [ADP-forming] subunit beta; succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; succinate-CoA ligase ADP-forming beta subunit; succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial; succinyl-CoA synthetase beta-A chain", "tax_id": 9913, "disease": "", "pathway": " (bta:511090)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as an ATP-specific itaconyl- and malyl-CoA synthetase., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.9", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0004775 succinate-CoA ligase (ADP-forming) activity;GO:0050074 malate-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042709 succinate-CoA ligase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006104 succinyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q148D5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q148F3-1", "uniprot_id": [ { "id": "ARSK_BOVIN", "url": "https://www.uniprot.org/uniprot/Q148F3", "type": "external" } ], "mass": 61361.0, "length": 540, "protein_name": "Arylsulfatase K", "gene_name": "ARSK", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ARSK", "gene_names_refseq": "", "protein_names_uniprotkb": "Arylsulfatase K; 3.1.6.18; 3.1.6.1; ASK; Glucuronate-2-sulfatase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1663150); (R-BTA-9840310)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (By similarity). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (By similarity). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.-", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.8.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.7", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004065 arylsulfatase activity;GO:0015024 glucuronate-2-sulfatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q148F3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q148H8-1", "uniprot_id": [ { "id": "K2C72_BOVIN", "url": "https://www.uniprot.org/uniprot/Q148H8", "type": "external" } ], "mass": 56930.0, "length": 524, "protein_name": "Keratin, type II cytoskeletal 72", "gene_name": "KRT72", "organism": "Bovine", "refseq_name": "keratin, type II cytoskeletal 72", "refseq_ac": [ { "id": "NP_001069412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069412", "type": "external" } ], "gene_names_uniprotkb": "KRT72", "gene_names_refseq": "KRT72", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 72; CK-72; Cytokeratin-72; K72; Keratin-72; Type II inner root sheath-specific keratin-K6irs2; Type-II keratin Kb35", "protein_names_refseq": "CK-72; K72; cytokeratin-72; keratin, type II cytoskeletal 72; type II inner root sheath-specific keratin-K6irs2; type-II keratin Kb35", "tax_id": 9913, "disease": "", "pathway": " (bta:531057); (R-BTA-6805567); (R-BTA-6809371)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q148H8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QD8-1", "uniprot_id": [ { "id": "G37L1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QD8", "type": "external" } ], "mass": 51930.0, "length": 482, "protein_name": "G protein-coupled receptor 37-like 1", "gene_name": "GPR37L1", "organism": "Bovine", "refseq_name": "G-protein coupled receptor 37-like 1 precursor", "refseq_ac": [ { "id": "NP_001069367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069367", "type": "external" } ], "gene_names_uniprotkb": "GPR37L1; ETBRLP2", "gene_names_refseq": "GPR37L1", "protein_names_uniprotkb": "G protein-coupled receptor 37-like 1; ETBR-LP-2; Endothelin B receptor-like protein 2", "protein_names_refseq": "ETBR-LP-2; G-protein coupled receptor 37-like 1 precursor; endothelin B receptor-like protein 2; prosaposin receptor GPR37L1", "tax_id": 9913, "disease": "", "pathway": " (bta:527572); (R-BTA-375276); (R-BTA-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "G protein-coupled receptor (By similarity). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity;GO:0036505 prosaposin receptor activity;GO:0042277 peptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0060170 ciliary membrane;GO:0042995 cell projection", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0003085 negative regulation of systemic arterial blood pressure;GO:0034614 cellular response to reactive oxygen species", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q17QD8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QG2-1", "uniprot_id": [ { "id": "NUDC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QG2", "type": "external" } ], "mass": 38243.0, "length": 332, "protein_name": "Nuclear migration protein nudC", "gene_name": "NUDC", "organism": "Bovine", "refseq_name": "nuclear migration protein nudC", "refseq_ac": [ { "id": "NP_001069075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069075", "type": "external" } ], "gene_names_uniprotkb": "NUDC", "gene_names_refseq": "NUDC", "protein_names_uniprotkb": "Nuclear migration protein nudC; Nuclear distribution protein C homolog", "protein_names_refseq": "nuclear distribution gene C homolog; nuclear distribution protein C homolog; nuclear migration protein nudC", "tax_id": 9913, "disease": "", "pathway": " (bta:513277); (R-BTA-141430); (R-BTA-141444); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-5663220); (R-BTA-9648025); (R-BTA-9696270)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity). Necessary for cytokinesis and cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0030496 midbody;GO:0072686 mitotic spindle", "go_biological_process": "GO:0051301 cell division;GO:0006457 protein folding;GO:0007080 mitotic metaphase chromosome alignment;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q17QG2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QG3-1", "uniprot_id": [ { "id": "RIPL1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QG3", "type": "external" } ], "mass": 47010.0, "length": 403, "protein_name": "RILP-like protein 1", "gene_name": "RILPL1", "organism": "Bovine", "refseq_name": "RILP-like protein 1", "refseq_ac": [ { "id": "NP_001068694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068694", "type": "external" } ], "gene_names_uniprotkb": "RILPL1", "gene_names_refseq": "RILPL1", "protein_names_uniprotkb": "RILP-like protein 1; Rab-interacting lysosomal-like protein 1", "protein_names_refseq": "RILP-like protein 1; rab-interacting lysosomal-like protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:505840)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (By similarity). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0031267 small GTPase binding;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0007263 nitric oxide mediated signal transduction;GO:0060271 cilium assembly;GO:0003382 epithelial cell morphogenesis;GO:1903445 protein transport from ciliary membrane to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q17QG3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QL1-1", "uniprot_id": [ { "id": "GNPI2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QL1", "type": "external" } ], "mass": 31165.0, "length": 276, "protein_name": "Glucosamine-6-phosphate deaminase 2", "gene_name": "GNPDA2", "organism": "Bovine", "refseq_name": "glucosamine-6-phosphate deaminase 2", "refseq_ac": [ { "id": "NP_001068824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068824", "type": "external" } ], "gene_names_uniprotkb": "GNPDA2", "gene_names_refseq": "GNPDA2", "protein_names_uniprotkb": "Glucosamine-6-phosphate deaminase 2; 3.5.99.6; GlcN6P deaminase 2; Glucosamine-6-phosphate isomerase 2", "protein_names_refseq": "GNPDA 2; glcN6P deaminase 2; glucosamine-6-phosphate deaminase 2; glucosamine-6-phosphate isomerase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:508383); (R-BTA-70171)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.99.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.99.6", "type": "external" } ], "go_molecular_function": "GO:0004342 glucosamine-6-phosphate deaminase activity;GO:0042802 identical protein binding;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006043 glucosamine catabolic process;GO:0006046 N-acetylglucosamine catabolic process;GO:0005975 carbohydrate metabolic process;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0019262 N-acetylneuraminate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q17QL1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QS4-1", "uniprot_id": [ { "id": "PI5L1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QS4", "type": "external" } ], "mass": 44778.0, "length": 396, "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase-like protein 1", "gene_name": "PIP5KL1", "organism": "Bovine", "refseq_name": "phosphatidylinositol 4-phosphate 5-kinase-like protein 1", "refseq_ac": [ { "id": "NP_001069315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069315", "type": "external" } ], "gene_names_uniprotkb": "PIP5KL1", "gene_names_refseq": "PIP5KL1", "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; PI(4)P 5-kinase-like protein 1; PtdIns(4)P-5-kinase-like protein 1", "protein_names_refseq": "PI(4)P 5-kinase-like protein 1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1; ptdIns(4)P-5-kinase-like protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:523736)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Likely functions as a regulatory or scaffold-like protein that modulates the subcellular localization and activity of type I PI(4)P 5-kinases (PIPKs) (By similarity). Lacks intrinsic lipid kinase activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58DG8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:0052742 phosphatidylinositol kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005829 cytosol;GO:0016020 membrane;GO:0042995 cell projection", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0010917 negative regulation of mitochondrial membrane potential;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0030336 negative regulation of cell migration;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q17QS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QU5-1", "uniprot_id": [ { "id": "LST8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QU5", "type": "external" } ], "mass": 35920.0, "length": 326, "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "organism": "Bovine", "refseq_name": "target of rapamycin complex subunit LST8", "refseq_ac": [ { "id": "NP_001030488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030488", "type": "external" } ], "gene_names_uniprotkb": "MLST8; GBL; LST8", "gene_names_refseq": "GBL; MLST8", "protein_names_uniprotkb": "Target of rapamycin complex subunit LST8; G protein beta subunit-like; Mammalian lethal with SEC13 protein 8; Protein GbetaL; TORC subunit LST8; mLST8", "protein_names_refseq": "TORC subunit LST8; mammalian lethal with SEC13 protein 8; protein GbetaL; target of rapamycin complex subunit LST8", "tax_id": 9913, "disease": "", "pathway": " (bta:535236); (R-BTA-1632852); (R-BTA-165159); (R-BTA-166208); (R-BTA-3371571); (R-BTA-380972); (R-BTA-5628897); (R-BTA-8943724); (R-BTA-9639288)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy. The mTORC1 complex is inhibited in response to starvation and amino acid depletion. Within mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. As part of the mTORC2 complex, transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1. mTORC2 functions upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MLST8 acts as a bridge between MAPKAP1/SIN1 and MTOR., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58DN5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005765 lysosomal membrane;GO:0031931 TORC1 complex;GO:0031932 TORC2 complex", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0031929 TOR signaling;GO:0038203 TORC2 signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q17QU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QW3-1", "uniprot_id": [ { "id": "RDH14_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QW3", "type": "external" } ], "mass": 36625.0, "length": 336, "protein_name": "Retinol dehydrogenase 14", "gene_name": "RDH14", "organism": "Bovine", "refseq_name": "retinol dehydrogenase 14", "refseq_ac": [ { "id": "NP_001068701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068701", "type": "external" } ], "gene_names_uniprotkb": "RDH14", "gene_names_refseq": "RDH14", "protein_names_uniprotkb": "Retinol dehydrogenase 14; 1.1.1.300", "protein_names_refseq": "retinol dehydrogenase 14 (all-trans/9-cis/11-cis); retinol dehydrogenase 14", "tax_id": 9913, "disease": "", "pathway": " (bta:505949); (R-BTA-5365859)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12226107;19393038", "class_list": "", "function": "Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-retinol. Has no activity towards steroid., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.357", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.188", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.188", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" } ], "go_molecular_function": "GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0102354 11-cis-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0042572 retinol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q17QW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17R09-1", "uniprot_id": [ { "id": "PRP16_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17R09", "type": "external" } ], "mass": 140405.0, "length": 1227, "protein_name": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "gene_name": "DHX38", "organism": "Bovine", "refseq_name": "pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "refseq_ac": [ { "id": "NP_001069266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069266", "type": "external" } ], "gene_names_uniprotkb": "DHX38; PRP16", "gene_names_refseq": "DHX38", "protein_names_uniprotkb": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; 3.6.4.13; ATP-dependent RNA helicase DHX38; DEAH box protein 38", "protein_names_refseq": "ATP-dependent RNA helicase DHX38; DEAH (Asp-Glu-Ala-His) box polypeptide 38; DEAH box protein 38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "tax_id": 9913, "disease": "", "pathway": " (bta:520046); (R-BTA-159236); (R-BTA-72163)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0034458 3'-5' RNA helicase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q17R09-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1HE26-1", "uniprot_id": [ { "id": "SMAD4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1HE26", "type": "external" } ], "mass": 60542.0, "length": 553, "protein_name": "SMAD family member 4", "gene_name": "SMAD4", "organism": "Bovine", "refseq_name": "SMAD family member 4", "refseq_ac": [ { "id": "NP_001069677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069677", "type": "external" } ], "gene_names_uniprotkb": "SMAD4", "gene_names_refseq": "SMAD4", "protein_names_uniprotkb": "SMAD family member 4; MAD homolog 4; Mothers against DPP homolog 4; Mothers against decapentaplegic homolog 4; SMAD 4", "protein_names_refseq": "MAD homolog 4; SMAD 4; SMAD family member 4; mothers against DPP homolog 4; mothers against DPP-like 4; mothers against decapentaplegic homolog 4", "tax_id": 9913, "disease": "", "pathway": " (bta:540248)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16004987;25031360", "class_list": "", "function": "ALK5 and Smad4 have roles in TGF-beta1-induced pulmonary endothelial permeability, [RefSeq, PubMed]; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 (By similarity)., [UniProtKB]; Data suggest SMAD4 mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and is decreased in remaining ectogenesis; embryotrophic actions of follistatin are SMAD4 dependent., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070411 I-SMAD binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1HE26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JPJ0-1", "uniprot_id": [ { "id": "NDOR1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JPJ0", "type": "external" } ], "mass": 66568.0, "length": 597, "protein_name": "NADPH-dependent diflavin oxidoreductase 1", "gene_name": "NDOR1", "organism": "Bovine", "refseq_name": "NADPH-dependent diflavin oxidoreductase 1", "refseq_ac": [ { "id": "NP_001039623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039623", "type": "external" } ], "gene_names_uniprotkb": "NDOR1", "gene_names_refseq": "NDOR1", "protein_names_uniprotkb": "NADPH-dependent diflavin oxidoreductase 1; 1.18.1.-; NADPH-dependent FMN and FAD-containing oxidoreductase", "protein_names_refseq": "NADPH-dependent FMN and FAD-containing oxidoreductase; NADPH-dependent diflavin oxidoreductase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:513873)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16305752;19393038", "class_list": "", "function": "NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair (By similarity). In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A (By similarity)., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3MXY0", "ec_number_list": [ { "id": "1.18.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.18.1.-", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0050660 flavin adenine dinucleotide binding;GO:0016491 oxidoreductase activity;GO:0010181 FMN binding;GO:0050661 NADP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0022900 electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1JPJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JQ93-1", "uniprot_id": [ { "id": "DPM1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JQ93", "type": "external" } ], "mass": 29592.0, "length": 260, "protein_name": "Dolichol-phosphate mannosyltransferase subunit 1", "gene_name": "DPM1", "organism": "Bovine", "refseq_name": "dolichol-phosphate mannosyltransferase subunit 1", "refseq_ac": [ { "id": "NP_001069481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069481", "type": "external" } ], "gene_names_uniprotkb": "DPM1", "gene_names_refseq": "DPM1; DPMS", "protein_names_uniprotkb": "Dolichol-phosphate mannosyltransferase subunit 1; 2.4.1.83; DPM synthase subunit 1; Dolichol-phosphate mannose synthase subunit 1; Dolichyl-phosphate beta-D-mannosyltransferase subunit 1; MPD synthase subunit 1; Mannose-P-dolichol synthase subunit 1", "protein_names_refseq": "DPM synthase subunit 1; MPD synthase subunit 1; dolichol-phosphate mannose synthase subunit 1; dolichol-phosphate mannosyltransferase subunit 1; dolichyl-phosphate beta-D-mannosyltransferase subunit 1; dolichyl-phosphate mannosyltransferase 1; dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit; mannose-P-dolichol synthase subunit 1", "tax_id": 9913, "disease": "", "pathway": " (bta:534097)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19214747", "class_list": "glycogene;glycosyltransferase", "function": "DNA sequencing and the deduced amino acid sequence have established that bDPMS has a motif to be phosphorylated by cAMP-dependent protein kinase (PKA)., [RefSeq, PubMed]; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.83", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.83", "type": "external" } ], "go_molecular_function": "GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0035269 protein O-linked glycosylation via mannose;GO:0006506 GPI anchor biosynthetic process;GO:0180047 dolichol phosphate mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1JQ93-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JQ97-1", "uniprot_id": [ { "id": "BBS4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JQ97", "type": "external" } ], "mass": 58221.0, "length": 519, "protein_name": "BBSome complex member BBS4", "gene_name": "BBS4", "organism": "Bovine", "refseq_name": "BBSome complex member BBS4", "refseq_ac": [ { "id": "NP_001069424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069424", "type": "external" } ], "gene_names_uniprotkb": "BBS4", "gene_names_refseq": "BBS4", "protein_names_uniprotkb": "BBSome complex member BBS4; Bardet-Biedl syndrome 4 protein homolog", "protein_names_refseq": "BBSome complex member BBS4; bardet-Biedl syndrome 4 protein homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:532120); (R-BTA-5620922)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005929 cilium;GO:0031514 motile cilium;GO:0097730 non-motile cilium", "go_biological_process": "GO:0015031 protein transport;GO:0007600 sensory perception;GO:0060271 cilium assembly;GO:0007098 centrosome cycle;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1JQ97-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JQA1-1", "uniprot_id": [ { "id": "UBE3D_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JQA1", "type": "external" } ], "mass": 43392.0, "length": 389, "protein_name": "E3 ubiquitin-protein ligase E3D", "gene_name": "UBE3D", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase E3D", "refseq_ac": [ { "id": "NP_001069179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069179", "type": "external" } ], "gene_names_uniprotkb": "UBE3D; H10BH; UBE2CBP", "gene_names_refseq": "UBE2CBP; UBE3D", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase E3D; 2.3.2.26; HECT-type E3 ubiquitin transferase E3D; UbcH10-binding protein with a HECT-like domain; Ubiquitin-conjugating enzyme E2C-binding protein", "protein_names_refseq": "E3 ubiquitin-protein ligase E3D; HECT-type E3 ubiquitin transferase E3D; UbcH10-binding protein with a HECT-like domain; ubiquitin-conjugating enzyme E2C-binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:515386); (R-BTA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0030332 cyclin binding;GO:0008428 ribonuclease inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1JQA1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JQA5-1", "uniprot_id": [ { "id": "NENF_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JQA5", "type": "external" } ], "mass": 18313.0, "length": 169, "protein_name": "Neudesin", "gene_name": "NENF", "organism": "Bovine", "refseq_name": "neudesin precursor", "refseq_ac": [ { "id": "NP_001069887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069887", "type": "external" } ], "gene_names_uniprotkb": "NENF", "gene_names_refseq": "NENF", "protein_names_uniprotkb": "Neudesin; Neuron-derived neurotrophic factor; SCIRP10-related protein; Spinal cord injury-related protein 10", "protein_names_refseq": "SCIRP10-related protein; neudesin precursor; spinal cord injury-related protein 10", "tax_id": 9913, "disease": "", "pathway": " (bta:616334)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (By similarity). Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Also acts as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0032099 negative regulation of appetite", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1JQA5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JQE6-1", "uniprot_id": [ { "id": "NCEH1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JQE6", "type": "external" } ], "mass": 46026.0, "length": 408, "protein_name": "Neutral cholesterol ester hydrolase 1", "gene_name": "NCEH1", "organism": "Bovine", "refseq_name": "neutral cholesterol ester hydrolase 1", "refseq_ac": [ { "id": "NP_001116506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116506", "type": "external" } ], "gene_names_uniprotkb": "NCEH1; AADACL1", "gene_names_refseq": "AADACL1; NCEH1", "protein_names_uniprotkb": "Neutral cholesterol ester hydrolase 1; 2-acetyl MAGE hydrolase; 3.1.1.-; 3.1.1.71; Acetylalkylglycerol acetylhydrolase; Arylacetamide deacetylase-like 1; NCEH", "protein_names_refseq": "2-acetyl MAGE hydrolase; NCEH; acetylalkylglycerol acetylhydrolase; arylacetamide deacetylase-like 1; neutral cholesterol ester hydrolase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:534212); (R-BTA-8964038)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.71", "type": "external" } ], "go_molecular_function": "GO:0017171 serine hydrolase activity;GO:0047378 acetylalkylglycerol acetylhydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0046485 ether lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1JQE6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZ71-1", "uniprot_id": [ { "id": "LFG2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZ71", "type": "external" } ], "mass": 35184.0, "length": 316, "protein_name": "Protein lifeguard 2", "gene_name": "FAIM2", "organism": "Bovine", "refseq_name": "protein lifeguard 2", "refseq_ac": [ { "id": "NP_001068886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068886", "type": "external" } ], "gene_names_uniprotkb": "FAIM2; LFG2", "gene_names_refseq": "FAIM2", "protein_names_uniprotkb": "Protein lifeguard 2; Fas apoptotic inhibitory molecule 2", "protein_names_refseq": "protein lifeguard 2", "tax_id": 9913, "disease": "", "pathway": " (bta:509790)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0045121 membrane raft;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0021681 cerebellar granular layer development;GO:0006915 apoptotic process;GO:0043524 negative regulation of neuron apoptotic process;GO:0021680 cerebellar Purkinje cell layer development;GO:0043523 regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1LZ71-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZ95-1", "uniprot_id": [ { "id": "IDI1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZ95", "type": "external" } ], "mass": 26467.0, "length": 227, "protein_name": "Isopentenyl-diphosphate Delta-isomerase 1", "gene_name": "IDI1", "organism": "Bovine", "refseq_name": "isopentenyl-diphosphate Delta-isomerase 1", "refseq_ac": [ { "id": "NP_001069127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069127", "type": "external" } ], "gene_names_uniprotkb": "IDI1", "gene_names_refseq": "IDI1", "protein_names_uniprotkb": "Isopentenyl-diphosphate Delta-isomerase 1; 5.3.3.2; IPP isomerase 1; IPPI1; Isopentenyl pyrophosphate isomerase 1", "protein_names_refseq": "IPP isomerase 1; IPPI1; isopentenyl pyrophosphate isomerase 1; isopentenyl-diphosphate Delta-isomerase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:514293); (R-BTA-9969896)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.2", "type": "external" } ], "go_molecular_function": "GO:0004452 isopentenyl-diphosphate delta-isomerase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0009240 isopentenyl diphosphate biosynthetic process;GO:0050992 dimethylallyl diphosphate biosynthetic process;GO:0006695 cholesterol biosynthetic process;GO:0035634 response to stilbenoid;GO:0033386 geranylgeranyl diphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1LZ95-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZA1-1", "uniprot_id": [ { "id": "CAH1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZA1", "type": "external" } ], "mass": 28822.0, "length": 261, "protein_name": "Carbonic anhydrase 1", "gene_name": "CA1", "organism": "Bovine", "refseq_name": "carbonic anhydrase 1", "refseq_ac": [ { "id": "NP_001068934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068934", "type": "external" } ], "gene_names_uniprotkb": "CA1", "gene_names_refseq": "CA1", "protein_names_uniprotkb": "Carbonic anhydrase 1; 4.2.1.1; 4.2.1.69; CA-I; Carbonate dehydratase I; Carbonic anhydrase I; Cyanamide hydratase CA1", "protein_names_refseq": "CA-I; carbonate dehydratase I; carbonic anhydrase 1; cyanamide hydratase CA1", "tax_id": 9913, "disease": "", "pathway": " (bta:510801); (R-BTA-1237044); (R-BTA-1247673); (R-BTA-1475029)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21575584", "class_list": "", "function": "Catalyzes the reversible hydration of carbon dioxide. Can hydrate cyanamide to urea., [UniProtKB, UniProtKB]; Time-resolved kinetics for dansylamide binding to carbonic anhydrase in solutions crowded with polyethylene glycol and Ficoll, were measured., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity;GO:0018820 cyanamide hydratase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1LZA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZD9-1", "uniprot_id": [ { "id": "PSPC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZD9", "type": "external" } ], "mass": 58275.0, "length": 520, "protein_name": "Paraspeckle component 1", "gene_name": "PSPC1", "organism": "Bovine", "refseq_name": "paraspeckle component 1", "refseq_ac": [ { "id": "NP_001068745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068745", "type": "external" } ], "gene_names_uniprotkb": "PSPC1", "gene_names_refseq": "PSPC1", "protein_names_uniprotkb": "Paraspeckle component 1", "protein_names_refseq": "paraspeckle component 1", "tax_id": 9913, "disease": "", "pathway": " (bta:506696)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA-binding protein required for the formation of nuclear paraspeckles (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (By similarity). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045087 innate immune response;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1LZD9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZE1-1", "uniprot_id": [ { "id": "KCMF1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZE1", "type": "external" } ], "mass": 41947.0, "length": 381, "protein_name": "E3 ubiquitin-protein ligase KCMF1", "gene_name": "KCMF1", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase KCMF1", "refseq_ac": [ { "id": "NP_001069743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069743", "type": "external" } ], "gene_names_uniprotkb": "KCMF1", "gene_names_refseq": "KCMF1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase KCMF1; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase KCMF1; RING-type E3 ubiquitin transferase KCMF1", "tax_id": 9913, "disease": "", "pathway": " (bta:613522)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (By similarity). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Does not ubiquitinate proteins that are acetylated at the N-terminus (By similarity). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (By similarity). Catalytic component of the silencing factor of the integrated stress response (SIFI) complex, a multiprotein complex that turns off the mitochondrial stress response after a specific stress event has been resolved (By similarity). The SIFI complex ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors such as ABHD10 (By similarity). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:0070534 protein K63-linked ubiquitination;GO:0099536 synaptic signaling;GO:0141191 negative regulation of HRI-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1LZE1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZE6-1", "uniprot_id": [ { "id": "CHPT1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZE6", "type": "external" } ], "mass": 45249.0, "length": 406, "protein_name": "Cholinephosphotransferase 1", "gene_name": "CHPT1", "organism": "Bovine", "refseq_name": "cholinephosphotransferase 1", "refseq_ac": [ { "id": "NP_001068975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068975", "type": "external" } ], "gene_names_uniprotkb": "CHPT1; CPT1", "gene_names_refseq": "CHPT1", "protein_names_uniprotkb": "Cholinephosphotransferase 1; 2.7.8.2; Diacylglycerol cholinephosphotransferase 1", "protein_names_refseq": "cholinephosphotransferase 1; diacylglycerol cholinephosphotransferase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:511291); (R-BTA-1483191)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the formation and maintenance of vesicular membranes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.2", "type": "external" }, { "id": "2.7.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.1", "type": "external" }, { "id": "2.7.8.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.22", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004142 diacylglycerol cholinephosphotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1LZE6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZF7-1", "uniprot_id": [ { "id": "PTH1R_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZF7", "type": "external" } ], "mass": 65862.0, "length": 589, "protein_name": "Parathyroid hormone/parathyroid hormone-related peptide receptor", "gene_name": "PTH1R", "organism": "Bovine", "refseq_name": "parathyroid hormone/parathyroid hormone-related peptide receptor precursor", "refseq_ac": [ { "id": "NP_001068800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068800", "type": "external" } ], "gene_names_uniprotkb": "PTH1R; PTHR1", "gene_names_refseq": "PTH1R; PTHR1", "protein_names_uniprotkb": "Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; Parathyroid hormone 1 receptor", "protein_names_refseq": "PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; parathyroid hormone receptor 1; parathyroid hormone/parathyroid hormone-related peptide receptor precursor; parathyroid hormone/parathyroid hormone-related peptide receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:507783)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16820722", "class_list": "", "function": "G protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH., [UniProtKB, UniProtKB]; The expression of the PTH/PTHrP receptor in dairy cows before and after parturition is reported., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004991 parathyroid hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0006874 intracellular calcium ion homeostasis;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1LZF7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZH7-1", "uniprot_id": [ { "id": "KANK2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZH7", "type": "external" } ], "mass": 91957.0, "length": 858, "protein_name": "KN motif and ankyrin repeat domain-containing protein 2", "gene_name": "KANK2", "organism": "Bovine", "refseq_name": "KN motif and ankyrin repeat domain-containing protein 2", "refseq_ac": [ { "id": "NP_001069999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069999", "type": "external" } ], "gene_names_uniprotkb": "KANK2; ANKRD25", "gene_names_refseq": "ANKRD25; KANK2", "protein_names_uniprotkb": "KN motif and ankyrin repeat domain-containing protein 2; Ankyrin repeat domain-containing protein 25", "protein_names_refseq": "Ankyrin repeat domain-containing protein 25; KN motif and ankyrin repeat domain-containing protein 2; ankyrin repeat domain 25", "tax_id": 9913, "disease": "", "pathway": " (bta:767586)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (By similarity). Through the Rho signaling pathway may also regulate cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0070563 negative regulation of vitamin D receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1LZH7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMI1-1", "uniprot_id": [ { "id": "GP183_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMI1", "type": "external" } ], "mass": 41179.0, "length": 360, "protein_name": "G protein-coupled receptor 183", "gene_name": "GPR183", "organism": "Bovine", "refseq_name": "G-protein coupled receptor 183", "refseq_ac": [ { "id": "NP_001039937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039937", "type": "external" } ], "gene_names_uniprotkb": "GPR183", "gene_names_refseq": "EBI2; GPR183", "protein_names_uniprotkb": "G protein-coupled receptor 183", "protein_names_refseq": "Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor); G-protein coupled receptor 183", "tax_id": 9913, "disease": "", "pathway": " (bta:540287); (R-BTA-373076); (R-BTA-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "G protein-coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (By similarity). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (By similarity). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (By similarity). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (By similarity). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0002312 B cell activation involved in immune response;GO:0036145 dendritic cell homeostasis;GO:2000458 regulation of astrocyte chemotaxis;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMI1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMJ6-1", "uniprot_id": [ { "id": "RHOC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMJ6", "type": "external" } ], "mass": 22006.0, "length": 193, "protein_name": "Rho-related GTP-binding protein RhoC", "gene_name": "RHOC", "organism": "Bovine", "refseq_name": "rho-related GTP-binding protein RhoC", "refseq_ac": [ { "id": "NP_001039603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039603", "type": "external" } ], "gene_names_uniprotkb": "RHOC; ARHC", "gene_names_refseq": "RHOC", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoC; 3.6.5.2", "protein_names_refseq": "ras homolog gene family, member C; rho-related GTP-binding protein RhoC", "tax_id": 9913, "disease": "", "pathway": " (bta:513152); (R-BTA-416482); (R-BTA-416572); (R-BTA-5625740); (R-BTA-5625900); (R-BTA-5627117); (R-BTA-5663220); (R-BTA-9013106)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032154 cleavage furrow;GO:0032420 stereocilium", "go_biological_process": "GO:0043297 apical junction assembly;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMJ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMS2-1", "uniprot_id": [ { "id": "PYRG2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMS2", "type": "external" } ], "mass": 65481.0, "length": 586, "protein_name": "CTP synthase 2", "gene_name": "CTPS2", "organism": "Bovine", "refseq_name": "CTP synthase 2", "refseq_ac": [ { "id": "NP_001070434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070434", "type": "external" } ], "gene_names_uniprotkb": "CTPS2", "gene_names_refseq": "CTPS2", "protein_names_uniprotkb": "CTP synthase 2; 6.3.4.2; CTP synthetase 2; UTP--ammonia ligase 2", "protein_names_refseq": "CTP synthase 2; CTP synthase II; CTP synthetase 2; UTP--ammonia ligase 2; cytidine triphosphate synthase II", "tax_id": 9913, "disease": "", "pathway": " (bta:767849); (R-BTA-499943)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D9B0", "ec_number_list": [ { "id": "6.3.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003883 CTP synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097268 cytoophidium", "go_biological_process": "GO:0044210 'de novo' CTP biosynthetic process;GO:0006241 CTP biosynthetic process;GO:0019856 pyrimidine nucleobase biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1RMS2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMU8-1", "uniprot_id": [ { "id": "NPY1R_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMU8", "type": "external" } ], "mass": 44291.0, "length": 383, "protein_name": "Neuropeptide Y receptor type 1", "gene_name": "NPY1R", "organism": "Bovine", "refseq_name": "neuropeptide Y receptor type 1", "refseq_ac": [ { "id": "NP_001039363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039363", "type": "external" } ], "gene_names_uniprotkb": "NPY1R", "gene_names_refseq": "NPY1R", "protein_names_uniprotkb": "Neuropeptide Y receptor type 1; NPY1-R", "protein_names_refseq": "NPY1-R; neuropeptide Y receptor type 1", "tax_id": 9913, "disease": "", "pathway": " (bta:504813); (R-BTA-375276); (R-BTA-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for neuropeptide Y (NPY) and peptide YY (PYY). Can also bind with high affinity [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form, while having virtually no affinity for pancreatic polypeptide (PP/PPY) at physiological concentrations. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels. As a receptor for NPY, it is involved in the regulation of eating behaviour and NPY-induced stimulation of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001601 peptide YY receptor activity;GO:0001602 pancreatic polypeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0003151 outflow tract morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMU8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMW1-1", "uniprot_id": [ { "id": "UBE2F_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMW1", "type": "external" } ], "mass": 21133.0, "length": 185, "protein_name": "NEDD8-conjugating enzyme UBE2F", "gene_name": "UBE2F", "organism": "Bovine", "refseq_name": "NEDD8-conjugating enzyme UBE2F", "refseq_ac": [ { "id": "NP_001069911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069911", "type": "external" } ], "gene_names_uniprotkb": "UBE2F", "gene_names_refseq": "UBE2F", "protein_names_uniprotkb": "NEDD8-conjugating enzyme UBE2F; 2.3.2.34; NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2; RING-type E3 NEDD8 transferase UBE2F; Ubiquitin-conjugating enzyme E2 F", "protein_names_refseq": "NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2; NEDD8-conjugating enzyme UBE2F; RING-type E3 NEDD8 transferase UBE2F; ubiquitin-conjugating enzyme E2 F; ubiquitin-conjugating enzyme E2F (putative)", "tax_id": 9913, "disease": "", "pathway": " (bta:617083); (R-BTA-8951664); (R-BTA-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. Together with the E3 ubiquitin ligase RNF7/RBX2, specifically neddylates cullin-5 (CUL5). Does not neddylate CUL1, CUL2, CUL3, CUL4A or CUL4B. Mediates neddylation of the CUL9-RBX1 complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0061654 NEDD8 conjugating enzyme activity;GO:0005524 ATP binding;GO:0019788 NEDD8 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMW1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1W668-1", "uniprot_id": [ { "id": "SMAD2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1W668", "type": "external" } ], "mass": 52234.0, "length": 467, "protein_name": "SMAD family member 2", "gene_name": "SMAD2", "organism": "Bovine", "refseq_name": "SMAD family member 2", "refseq_ac": [ { "id": "NP_001039683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039683", "type": "external" } ], "gene_names_uniprotkb": "SMAD2", "gene_names_refseq": "SMAD2", "protein_names_uniprotkb": "SMAD family member 2; MAD homolog 2; Mothers against DPP homolog 2; Mothers against decapentaplegic homolog 2; SMAD 2", "protein_names_refseq": "MAD homolog 2; SMAD 2; SMAD family member 2; SMAD, mothers against DPP homolog 2; mothers against decapentaplegic homolog 2", "tax_id": 9913, "disease": "", "pathway": " (bta:516010)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23804438;24795273;26289443", "class_list": "", "function": "A detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7. Publication Status: Online-Only, [RefSeq, PubMed]; Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation., [RefSeq, PubMed]; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q1W668-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1XF11-1", "uniprot_id": [ { "id": "HCST_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1XF11", "type": "external" } ], "mass": 8218.0, "length": 79, "protein_name": "Hematopoietic cell signal transducer", "gene_name": "HCST", "organism": "Bovine", "refseq_name": "hematopoietic cell signal transducer precursor", "refseq_ac": [ { "id": "NP_001070445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070445", "type": "external" } ], "gene_names_uniprotkb": "HCST; DAP10", "gene_names_refseq": "DAP10; HCST", "protein_names_uniprotkb": "Hematopoietic cell signal transducer; DNAX-activation protein 10; Membrane protein DAP10", "protein_names_refseq": "DNAX-activation protein 10; hematopoietic cell signal transducer precursor; membrane protein DAP10; putative membrane adaptor molecule", "tax_id": 9913, "disease": "", "pathway": " (bta:767892); (R-BTA-198933)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17530242", "class_list": "", "function": "Cloning, sequencing, and cell surface expression pattern, [RefSeq, PubMed]; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as a docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1XF11-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24JY4-1", "uniprot_id": [ { "id": "ZNHI1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q24JY4", "type": "external" } ], "mass": 17536.0, "length": 154, "protein_name": "Zinc finger HIT domain-containing protein 1", "gene_name": "ZNHIT1", "organism": "Bovine", "refseq_name": "zinc finger HIT domain-containing protein 1", "refseq_ac": [ { "id": "NP_001039650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039650", "type": "external" } ], "gene_names_uniprotkb": "ZNHIT1", "gene_names_refseq": "ZNHIT1", "protein_names_uniprotkb": "Zinc finger HIT domain-containing protein 1; p18 Hamlet", "protein_names_refseq": "p18 Hamlet; zinc finger HIT domain-containing protein 1; zinc finger, HIT type 1", "tax_id": 9913, "disease": "", "pathway": " (bta:514997)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in chromatin remodeling by promoting the incorporation of histone variant H2AZ1/H2A.Z into the genome to regulate gene expression (By similarity). Promotes SRCAP complex-mediated deposition of histone variant H2AZ1 to lymphoid fate regulator genes, enhancing lymphoid lineage commitment (By similarity). Recruited to the promoter of the transcriptional activator MYOG at the early stages of muscle differentiation where it mediates binding of histone H2AZ1 to chromatin and induces muscle-specific gene expression (By similarity). Maintains hematopoietic stem cell (HSC) quiescence by determining the chromatin accessibility at distal enhancers of HSC quiescence genes such as PTEN, FSTL1 and KLF4, enhancing deposition of H2AZ1 to promote their sustained transcription and restricting PI3K-AKT signaling inhibition (By similarity). Plays a role in intestinal stem cell maintenance by promoting H2AZ1 deposition at the transcription start sites of genes involved in intestinal stem cell fate determination including LGR5, TGFB1 and TGFBR2, thereby contributing to gene transcription (By similarity). Promotes phosphorylation of the H2AZ1 chaperone VPS72/YL1 which enhances the interaction between HZAZ1 and VPS72 (By similarity). Regulates the entry of male germ cells into meiosis by controlling histone H2AZ1 deposition which facilitates the expression of meiotic genes such as MEIOSIN, leading to the initiation of meiosis (By similarity). Required for postnatal heart function through its role in maintenance of cardiac Ca(2+) homeostasis by modulating the expression of Ca(2+)-regulating proteins CASQ1 and ATP2A2/SERCA2A via deposition of histone H2AZ1 at their promoters (By similarity). During embryonic heart development, required for mitochondrial maturation and oxidative metabolism by functioning through H2AZ1 deposition to activate transcription of metabolic genes and is also required to maintain the stability of the respiratory complex (By similarity). In neural cells, increases deposition of the H2AZ1 histone variant and promotes neurite growth (By similarity). Plays a role in TP53/p53-mediated apoptosis induction by stimulating the transcriptional activation of several proapoptotic p53 target genes such as PMAIP1/NOXA and BBC3/PUMA (By similarity). Mediates cell cycle arrest induced in response to gamma-irradiation by enhancing recruitment of TP53/p53 to the promoter of the cell cycle inhibitor CDKN1A, leading to its transcriptional activation (By similarity). Recruited to the promoter of cyclin-dependent kinase CDK6 and inhibits its transcription, possibly by decreasing the acetylation level of histone H4, leading to cell cycle arrest at the G1 phase (By similarity). Plays a role in lens fiber cell differentiation by regulating the expression of cell cycle regulator CDKN1A/p21Cip1 (By similarity). Binds to transcriptional repressor NR1D2 and relieves it of its inhibitory effect on the transcription of apolipoprotein APOC3 without affecting its DNA-binding activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0042393 histone binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0000812 Swr1 complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q24JY4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27954-1", "uniprot_id": [ { "id": "COPA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27954", "type": "external" } ], "mass": 138359.0, "length": 1224, "protein_name": "Coatomer subunit alpha", "gene_name": "COPA", "organism": "Bovine", "refseq_name": "coatomer subunit alpha", "refseq_ac": [ { "id": "NP_001099115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099115", "type": "external" } ], "gene_names_uniprotkb": "COPA", "gene_names_refseq": "COPA", "protein_names_uniprotkb": "Coatomer subunit alpha; Alpha-COP; Alpha-coat protein; HEP-COP; HEPCOP; Xenopsin-related peptide", "protein_names_refseq": "HEP-COP; HEPCOP; alpha-COP; alpha-coat protein; coatomer protein complex subunit alpha; coatomer subunit alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:100126041)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26042826;8858162;9548716", "class_list": "", "function": "A missense mutation in the coatomer protein complex, subunit alpha (COPA), a gene with previously no known role in pigmentation synthesis, is completely associated with Dominant Red in Holstein dairy cattle. Publication Status: Online-Only, [RefSeq, PubMed]; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)., [UniProtKB]; Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7Z053", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q27954-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27965-1", "uniprot_id": [ { "id": "HS71B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27965", "type": "external" } ], "mass": 70228.0, "length": 641, "protein_name": "Heat shock 70 kDa protein 1B", "gene_name": "HSPA1B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HSPA1B; HSP70-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock 70 kDa protein 1B; HSP70.2; Heat shock 70 kDa protein 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:282254)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12755819;8249428", "class_list": "", "function": "Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation. Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle. Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q28122;Q3ZBV7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0042026 protein refolding;GO:1901673 regulation of mitotic spindle assembly;GO:0090063 positive regulation of microtubule nucleation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q27965-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27972-1", "uniprot_id": [ { "id": "CHAD_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27972", "type": "external" } ], "mass": 40885.0, "length": 361, "protein_name": "Chondroadherin", "gene_name": "CHAD", "organism": "Bovine", "refseq_name": "chondroadherin precursor", "refseq_ac": [ { "id": "NP_776444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776444", "type": "external" } ], "gene_names_uniprotkb": "CHAD", "gene_names_refseq": "CHAD", "protein_names_uniprotkb": "Chondroadherin; 38 kDa bone protein; Cartilage leucine-rich protein", "protein_names_refseq": "38 kDa bone protein; cartilage leucine-rich protein; chondroadherin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281069)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7814406;8063792", "class_list": "", "function": "Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q27972-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27981-1", "uniprot_id": [ { "id": "NRAM1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27981", "type": "external" } ], "mass": 59568.0, "length": 548, "protein_name": "Natural resistance-associated macrophage protein 1", "gene_name": "SLC11A1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC11A1; NRAMP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Natural resistance-associated macrophage protein 1; NRAMP 1; Solute carrier family 11 member 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:282470)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8908514", "class_list": "", "function": "Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005384 manganese ion transmembrane transporter activity;GO:0051139 metal cation:proton antiporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0030670 phagocytic vesicle membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0006826 iron ion transport;GO:0006828 manganese ion transport;GO:0030026 intracellular manganese ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q27981-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27996-1", "uniprot_id": [ { "id": "LYSCT_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27996", "type": "external" } ], "mass": 15929.0, "length": 147, "protein_name": "Lysozyme C, tracheal isozyme", "gene_name": "", "organism": "Bovine", "refseq_name": "lysozyme C, tracheal isozyme precursor", "refseq_ac": [ { "id": "NP_001073805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073805", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "LOC781146", "protein_names_uniprotkb": "Lysozyme C, tracheal isozyme; 1,4-beta-N-acetylmuramidase C; 3.2.1.17", "protein_names_refseq": "1,4-beta-N-acetylmuramidase C; lysozyme C, tracheal isozyme precursor; lysozyme C, tracheal isozyme", "tax_id": 9913, "disease": "", "pathway": " (bta:781146)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7563116", "class_list": "glycogene;glycosylhydrolase", "function": "Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q27996-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28001-1", "uniprot_id": [ { "id": "S6A17_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28001", "type": "external" } ], "mass": 25374.0, "length": 225, "protein_name": "Sodium-dependent neutral amino acid transporter SLC6A17", "gene_name": "SLC6A17", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC6A17; NTT4", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium-dependent neutral amino acid transporter SLC6A17; Sodium-dependent neurotransmitter transporter NTT4; Solute carrier family 6 member 17", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Synaptic vesicle transporter with apparent selectivity for neutral amino acids. The transport is sodium-coupled but chloride-independent, likely driven by the proton electrochemical gradient generated by vacuolar H(+)-ATPase in an overall electrogenic mechanism. May contribute to the synaptic uptake of neurotransmitter precursors in a process coupled in part to vesicle exocytosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0098794 postsynapse;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0015816 glycine transport;GO:0015820 L-leucine transport;GO:0015824 proline transport;GO:0032328 alanine transport;GO:0015804 neutral amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q28001-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28003-1", "uniprot_id": [ { "id": "CXCR2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28003", "type": "external" } ], "mass": 40625.0, "length": 360, "protein_name": "C-X-C chemokine receptor type 2", "gene_name": "CXCR2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CXCR2; IL8RB", "gene_names_refseq": "", "protein_names_uniprotkb": "C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; High affinity interleukin-8 receptor B; IL-8R B", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281863)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Signals intravascular neutrophil chemotaxis to the injury site (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0019959 interleukin-8 binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0030593 neutrophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q28003-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28005-1", "uniprot_id": [ { "id": "LSHR_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28005", "type": "external" } ], "mass": 78456.0, "length": 701, "protein_name": "Lutropin-choriogonadotropic hormone receptor", "gene_name": "LHCGR", "organism": "Bovine", "refseq_name": "lutropin-choriogonadotropic hormone receptor precursor", "refseq_ac": [ { "id": "NP_776806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776806", "type": "external" } ], "gene_names_uniprotkb": "LHCGR", "gene_names_refseq": "LH/CG-R; LHCGR; LSH-R", "protein_names_uniprotkb": "Lutropin-choriogonadotropic hormone receptor; LH/CG-R; LSH-R; Luteinizing hormone receptor", "protein_names_refseq": "luteinizing hormone receptor 2 protein; lutropin-choriogonadotropic hormone receptor precursor; lutropin-choriogonadotropic hormone receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281900)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16481595;17121604;26318230;26446749;26507944;26845856;28840634;9532424", "class_list": "", "function": "Dominant follicles experience a reduction in FSH dependence (diminished expression of FSHR), but acquire increased LH dependence (enhanced expression of LHCGR) as they grow during the low FSH milieu of follicular waves., [RefSeq, PubMed]; Expression of LHR mRNA in bovine granulosa cells is established after follicle deviation, and the lower abundance of LRBP mRNA after the expected time of deviation may contribute to greater expression of LHR in the bovine dominant follicle, [RefSeq, PubMed]; Gene expression of granulosa cells reveals that 747 transcripts are potentially regulated by LH., [RefSeq, PubMed]; INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS, [RefSeq, PubMed]; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase., [UniProtKB, UniProtKB]; The outcomes of the present study support a dynamic multi-facetted regulation of LHR during pre-translation., [RefSeq, PubMed]; These results suggested an acute regulation of INSL3 by luteinizing hormone (LH) because INSL3 concentrations increased immediately after endogenous and exogenous LH stimulation., [RefSeq, PubMed]; Three single nucleotide polymorphisms in LHCGR were significantly associated with variations in cattle fertility and production traits., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "P79133;Q8SPS8", "ec_number_list": [], "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity;GO:0004964 luteinizing hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008584 male gonad development;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0009755 hormone-mediated signaling pathway;GO:0001541 ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q28005-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28030-1", "uniprot_id": [ { "id": "AT1B2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28030", "type": "external" } ], "mass": 33401.0, "length": 290, "protein_name": "Sodium/potassium-transporting ATPase subunit beta-2", "gene_name": "ATP1B2", "organism": "Bovine", "refseq_name": "sodium/potassium-transporting ATPase subunit beta-2", "refseq_ac": [ { "id": "NP_777102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777102", "type": "external" } ], "gene_names_uniprotkb": "ATP1B2", "gene_names_refseq": "ATP1B2", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit beta-2; Sodium/potassium-dependent ATPase subunit beta-2", "protein_names_refseq": "ATPase, Na+/K+ transporting, beta 2 polypeptide; sodium/potassium-dependent ATPase subunit beta-2; sodium/potassium-transporting ATPase subunit beta-2", "tax_id": 9913, "disease": "", "pathway": " (bta:282562)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20842439;8918259", "class_list": "", "function": "Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth., [UniProtKB]; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known., [UniProtKB]; This study suggests that the ATP1B2 single nucleotide polymorphism C2833T is a genetic marker of heat-resistance traits in Chinese Holstein cows., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0005890 sodium:potassium-exchanging ATPase complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0006883 intracellular sodium ion homeostasis;GO:0030007 intracellular potassium ion homeostasis;GO:0036376 sodium ion export across plasma membrane;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28030-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28037-1", "uniprot_id": [ { "id": "VDR_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28037", "type": "external" } ], "mass": 48318.0, "length": 426, "protein_name": "Vitamin D3 receptor", "gene_name": "VDR", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "VDR; NR1I1", "gene_names_refseq": "", "protein_names_uniprotkb": "Vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1; VDR", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:533656)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "6250480;8747330;8880453", "class_list": "", "function": "Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0005499 vitamin D binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070561 vitamin D receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q28037-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28038-1", "uniprot_id": [ { "id": "MIA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28038", "type": "external" } ], "mass": 14354.0, "length": 130, "protein_name": "Melanoma-derived growth regulatory protein", "gene_name": "MIA", "organism": "Bovine", "refseq_name": "melanoma-derived growth regulatory protein precursor", "refseq_ac": [ { "id": "NP_776361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776361", "type": "external" } ], "gene_names_uniprotkb": "MIA; CDRAP", "gene_names_refseq": "MIA", "protein_names_uniprotkb": "Melanoma-derived growth regulatory protein; CD-RAP; Cartilage-derived retinoic acid-sensitive protein; Melanoma inhibitory activity protein", "protein_names_refseq": "CD-RAP; cartilage-derived retinoic acid-sensitive protein; melanoma inhibitory activity protein; melanoma-derived growth regulatory protein precursor; melanoma-derived growth regulatory protein", "tax_id": 9913, "disease": "", "pathway": " (bta:280857)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8621736", "class_list": "", "function": "May function during cartilage development and maintenance., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28038-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28039-1", "uniprot_id": [ { "id": "SC6A9_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28039", "type": "external" } ], "mass": 71318.0, "length": 638, "protein_name": "Sodium- and chloride-dependent glycine transporter 1", "gene_name": "SLC6A9", "organism": "Bovine", "refseq_name": "sodium- and chloride-dependent glycine transporter 1 isoform 2", "refseq_ac": [ { "id": "NP_001229271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229271", "type": "external" } ], "gene_names_uniprotkb": "SLC6A9", "gene_names_refseq": "SLC6A9; glyT-1; glyT1", "protein_names_uniprotkb": "Sodium- and chloride-dependent glycine transporter 1; GlyT-1; GlyT1; Solute carrier family 6 member 9", "protein_names_refseq": "sodium- and chloride-dependent glycine transporter 1 isoform 2; sodium- and chloride-dependent glycine transporter 1; solute carrier family 6 (neurotransmitter transporter, glycine), member 9", "tax_id": 9913, "disease": "", "pathway": " (bta:282368)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sodium- and chloride-dependent glycine transporter which is essential for regulating glycine concentrations at inhibitory glycinergic synapses., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q28040;Q29420", "ec_number_list": [], "go_molecular_function": "GO:0005283 amino acid:sodium symporter activity;GO:0015375 glycine:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0035725 sodium ion transmembrane transport;GO:0006836 neurotransmitter transport;GO:1903804 glycine import across plasma membrane;GO:0060092 regulation of synaptic transmission, glycinergic", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q28039-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28042-1", "uniprot_id": [ { "id": "OVGP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28042", "type": "external" } ], "mass": 59618.0, "length": 537, "protein_name": "Oviduct-specific glycoprotein", "gene_name": "OVGP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "OVGP1; OGP", "gene_names_refseq": "", "protein_names_uniprotkb": "Oviduct-specific glycoprotein; Estrogen-dependent oviduct protein; Oviductal glycoprotein; Oviductin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8199272", "class_list": "", "function": "Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004568 chitinase activity;GO:0008061 chitin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0030133 transport vesicle", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0007338 single fertilization;GO:0006032 chitin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28042-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28053-1", "uniprot_id": [ { "id": "A4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28053", "type": "external" } ], "mass": 6414.0, "length": 59, "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "APP", "gene_names_refseq": "", "protein_names_uniprotkb": "Amyloid-beta precursor protein; ABPP; APP; Alzheimer disease amyloid A4 protein homolog; Amyloid precursor protein; Amyloid-beta (A4) precursor protein; Amyloid-beta A4 protein; Beta-APP40; Beta-APP42; Gamma-CTF(57); Gamma-CTF(59)", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1656157", "class_list": "", "function": "Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP (By similarity). Inhibits G(o)-alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity). In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005769 early endosome;GO:0005798 Golgi-associated vesicle;GO:0005886 plasma membrane", "go_biological_process": "GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28053-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28060-1", "uniprot_id": [ { "id": "DSC3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28060", "type": "external" } ], "mass": 99687.0, "length": 896, "protein_name": "Desmocollin-3", "gene_name": "DSC3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DSC3", "gene_names_refseq": "", "protein_names_uniprotkb": "Desmocollin-3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "7673337;8034749", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (By similarity). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q28061;Q28176", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030057 desmosome", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28060-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28062-1", "uniprot_id": [ { "id": "PGCB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28062", "type": "external" } ], "mass": 99554.0, "length": 912, "protein_name": "Brevican core protein", "gene_name": "BCAN", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "BCAN", "gene_names_refseq": "", "protein_names_uniprotkb": "Brevican core protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8144512", "class_list": "", "function": "May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0072534 perineuronal net", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28062-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28071-1", "uniprot_id": [ { "id": "CD28_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28071", "type": "external" } ], "mass": 25143.0, "length": 219, "protein_name": "T-cell-specific surface glycoprotein CD28", "gene_name": "CD28", "organism": "Bovine", "refseq_name": "T-cell-specific surface glycoprotein CD28 precursor", "refseq_ac": [ { "id": "NP_851347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851347", "type": "external" } ], "gene_names_uniprotkb": "CD28", "gene_names_refseq": "CD28", "protein_names_uniprotkb": "T-cell-specific surface glycoprotein CD28", "protein_names_refseq": "T-cell-specific surface glycoprotein CD28 precursor; T-cell-specific surface glycoprotein CD28; antigen CD28", "tax_id": 9913, "disease": "", "pathway": " (bta:281050)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8606060", "class_list": "", "function": "Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis. Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0031295 T cell costimulation;GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0050862 positive regulation of T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28071-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28074-1", "uniprot_id": [ { "id": "CD3G_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28074", "type": "external" } ], "mass": 19463.0, "length": 173, "protein_name": "T-cell surface glycoprotein CD3 gamma chain", "gene_name": "CD3G", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CD3G", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell surface glycoprotein CD3 gamma chain; T-cell receptor T3 gamma chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1971793", "class_list": "", "function": "Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZA7", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0042105 alpha-beta T cell receptor complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0002250 adaptive immune response;GO:0045059 positive thymic T cell selection", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28074-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28083-1", "uniprot_id": [ { "id": "COBA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28083", "type": "external" } ], "mass": 89260.0, "length": 911, "protein_name": "Collagen alpha-1(XI) chain", "gene_name": "COL11A1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COL11A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(XI) chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1744123;8486632", "class_list": "", "function": "May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0048705 skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28083-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28084-1", "uniprot_id": [ { "id": "CO4A3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28084", "type": "external" } ], "mass": 47585.0, "length": 471, "protein_name": "Collagen alpha-3(IV) chain", "gene_name": "COL4A3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COL4A3", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-3(IV) chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "1985905;2318822;2438283;3417661", "class_list": "", "function": "Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005604 basement membrane;GO:0005581 collagen trimer", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q28084-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28106-1", "uniprot_id": [ { "id": "CNTN1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28106", "type": "external" } ], "mass": 113385.0, "length": 1018, "protein_name": "Contactin-1", "gene_name": "CNTN1", "organism": "Bovine", "refseq_name": "contactin-1 precursor", "refseq_ac": [ { "id": "NP_776705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776705", "type": "external" } ], "gene_names_uniprotkb": "CNTN1", "gene_names_refseq": "CNTN1", "protein_names_uniprotkb": "Contactin-1; Neural cell surface protein F3", "protein_names_refseq": "contactin-1 precursor; neural cell surface protein F3", "tax_id": 9913, "disease": "", "pathway": " (bta:281705)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7642103", "class_list": "", "function": "Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity)., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0098552 side of membrane", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0098609 cell-cell adhesion;GO:0007420 brain development;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28106-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28110-1", "uniprot_id": [ { "id": "FCGR2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28110", "type": "external" } ], "mass": 33020.0, "length": 296, "protein_name": "Low affinity immunoglobulin gamma Fc region receptor II", "gene_name": "FCGR2", "organism": "Bovine", "refseq_name": "low affinity immunoglobulin gamma Fc region receptor II-b precursor", "refseq_ac": [ { "id": "NP_776964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776964", "type": "external" } ], "gene_names_uniprotkb": "FCGR2", "gene_names_refseq": "CD32; FCGR2B; FCGR2; fcRII", "protein_names_uniprotkb": "Low affinity immunoglobulin gamma Fc region receptor II; Fc-gamma RII; FcRII; IgG Fc receptor II", "protein_names_refseq": "Fc fragment of IgG receptor IIb; Fc fragment of IgG, low affinity IIb, receptor (CD32); fc-gamma RII; igG Fc receptor II; low affinity immunoglobulin gamma Fc region receptor II-b precursor; low affinity immunoglobulin gamma Fc region receptor II-b; low affinity immunoglobulin gamma Fc region receptor II", "tax_id": 9913, "disease": "", "pathway": " (bta:282229)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31993051;8188320", "class_list": "", "function": "Binds to the Fc region of immunoglobulins gamma. Low affinity receptor., [UniProtKB]; Fcgamma Receptor IIB Controls Skin Inflammation in an Active Model of Epidermolysis Bullosa Acquisita. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019864 IgG binding;GO:0019770 IgG receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0050766 positive regulation of phagocytosis;GO:0032760 positive regulation of tumor necrosis factor production;GO:0001788 antibody-dependent cellular cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28110-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28133-1", "uniprot_id": [ { "id": "ALL2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28133", "type": "external" } ], "mass": 19560.0, "length": 172, "protein_name": "Allergen Bos d 2", "gene_name": "BDA20", "organism": "Bovine", "refseq_name": "allergen Bos d 2 precursor", "refseq_ac": [ { "id": "NP_777186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777186", "type": "external" } ], "gene_names_uniprotkb": "BDA20", "gene_names_refseq": "BDA20", "protein_names_uniprotkb": "Allergen Bos d 2; Dander major allergen BDA20; Dermal allergen BDA20", "protein_names_refseq": "allergen Bos d 2 precursor; allergen Bos d 2; dander major allergen BDA20; dermal allergen BDA20", "tax_id": 9913, "disease": "", "pathway": " (bta:286791)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18817327;8648026;9525451;9647765;9853680;9891000;9973397", "class_list": "", "function": "Probable pheromone carrier., [UniProtKB]; Two-point LOD scores showed that BDA20 is linked to XBM451 with a LOD score of 22.1 for a theta value of 0.03, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036094 small molecule binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q28133-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28153-1", "uniprot_id": [ { "id": "CELA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28153", "type": "external" } ], "mass": 28518.0, "length": 266, "protein_name": "Chymotrypsin-like elastase family member 1", "gene_name": "CELA1", "organism": "Bovine", "refseq_name": "chymotrypsin-like elastase family member 1 precursor", "refseq_ac": [ { "id": "NP_776473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776473", "type": "external" } ], "gene_names_uniprotkb": "CELA1; ELA1", "gene_names_refseq": "CELA1; ELA1", "protein_names_uniprotkb": "Chymotrypsin-like elastase family member 1; 3.4.21.36; Elastase I; Elastase-1", "protein_names_refseq": "chymotrypsin like elastase family member 1; chymotrypsin-like elastase family member 1 precursor; elastase 1, pancreatic; elastase I; elastase-1", "tax_id": 9913, "disease": "", "pathway": " (bta:281139)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9418008", "class_list": "", "function": "Serine proteases that hydrolyze many proteins in addition to elastin., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6QPW5", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28153-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28173-1", "uniprot_id": [ { "id": "RAGE_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28173", "type": "external" } ], "mass": 44182.0, "length": 416, "protein_name": "Advanced glycation end product-specific receptor", "gene_name": "AGER", "organism": "Bovine", "refseq_name": "advanced glycosylation end product-specific receptor precursor", "refseq_ac": [ { "id": "NP_776407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776407", "type": "external" } ], "gene_names_uniprotkb": "AGER; RAGE", "gene_names_refseq": "AGER; RAGE", "protein_names_uniprotkb": "Advanced glycation end product-specific receptor; Advanced glycosylation end product-specific receptor; Receptor for advanced glycation end products; Receptor for advanced glycosylation end products", "protein_names_refseq": "advanced glycosylation end product-specific receptor precursor; receptor for advanced glycosylation end products", "tax_id": 9913, "disease": "", "pathway": " (bta:280986)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1321822;1378843;19564763;37108174", "class_list": "", "function": "Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, histones, phospholipids and glycosaminoglycans. Advanced glycation end products (AGEs) are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. These ligands accumulate at inflammatory sites during the pathogenesis of various diseases including diabetes, vascular complications, neurodegenerative disorders and cancers, and RAGE transduces their binding into pro-inflammatory responses. Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction of inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (By similarity). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability. Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome. Binds to DNA and promotes extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (By similarity). Mediates phagocytosis by non-professional phagocytes (NPP) and this is enhanced by binding to ligands including RNA, DNA, HMGB1 and histones (By similarity). Promotes NPP-mediated phagocytosis of Saccharomyces cerevisiae spores by binding to RNA attached to the spore wall (By similarity). Also promotes NPP-mediated phagocytosis of apoptotic cells (By similarity). Following DNA damage, recruited to DNA double-strand break sites where it colocalizes with the MRN repair complex via interaction with double-strand break repair protein MRE11 (By similarity). Enhances the endonuclease activity of MRE11, promoting the end resection of damaged DNA (By similarity). Promotes DNA damage repair in trophoblasts which enhances trophoblast invasion and contributes to placental development and maintenance (By similarity). Protects cells from DNA replication stress by localizing to damaged replication forks where it stabilizes the MCM2-7 complex and promotes faithful progression of the replication fork (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Our results suggested that the increased RAGE expression in inflammatory circumstances and interaction with AGEs are risk factors in decreasing of aggrecan content in nucleus pulposus., [RefSeq, PubMed]; RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042393 histone binding;GO:0044548 S100 protein binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005769 early endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0001774 microglial cell activation;GO:0006281 DNA repair;GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q28173-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28203-1", "uniprot_id": [ { "id": "TNR5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28203", "type": "external" } ], "mass": 31062.0, "length": 280, "protein_name": "Tumor necrosis factor receptor superfamily member 5", "gene_name": "CD40", "organism": "Bovine", "refseq_name": "tumor necrosis factor receptor superfamily member 5 precursor", "refseq_ac": [ { "id": "NP_001099081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099081", "type": "external" } ], "gene_names_uniprotkb": "CD40; TNFRSF5", "gene_names_refseq": "CD40; TNFRSF5", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; CD40L receptor", "protein_names_refseq": "B-cell surface antigen CD40; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; tumor necrosis factor receptor superfamily member 5 precursor; tumor necrosis factor receptor superfamily, member 5", "tax_id": 9913, "disease": "", "pathway": " (bta:286849); (R-BTA-198933); (R-BTA-5668541); (R-BTA-5676594)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "19022505;23761659;9135560", "class_list": "", "function": "Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results demonstrated greater CD40 and CD40L expression on fresh mononuclear leukocytes obtained from animals in the clinical stage of Johne's Disease., [RefSeq, PubMed]; Study investigated the hypothesis that CD40 signalling is impaired in Mycobacterium avium subspecies paratuberculosis-infected macrophages, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A7YWS9", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0035631 CD40 receptor complex", "go_biological_process": "GO:0010557 positive regulation of macromolecule biosynthetic process;GO:0023035 CD40 signaling pathway;GO:0006952 defense response;GO:0006874 intracellular calcium ion homeostasis;GO:0042113 B cell activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q28203-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28838-1", "uniprot_id": [ { "id": "ADA2A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28838", "type": "external" } ], "mass": 51123.0, "length": 468, "protein_name": "Alpha-2A adrenergic receptor", "gene_name": "ADRA2A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ADRA2A", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; Alpha-2AAR; Alpha-2D adrenergic receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:282135); (R-BTA-390696); (R-BTA-392023); (R-BTA-400042); (R-BTA-418594); (R-BTA-418597); (R-BTA-5683826)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "19393038;8412494;9450652", "class_list": "", "function": "Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A3Q1LKS4", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0032795 heterotrimeric G-protein binding;GO:0004938 alpha2-adrenergic receptor activity;GO:0031696 alpha-2C adrenergic receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0098793 presynapse;GO:0098691 dopaminergic synapse", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0030335 positive regulation of cell migration;GO:0043410 positive regulation of MAPK cascade;GO:0051044 positive regulation of membrane protein ectodomain proteolysis;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q28838-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28852-1", "uniprot_id": [ { "id": "ATP5L_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28852", "type": "external" } ], "mass": 11417.0, "length": 103, "protein_name": "ATP synthase F(0) complex subunit g, mitochondrial", "gene_name": "ATP5MG", "organism": "Bovine", "refseq_name": "ATP synthase F(0) complex subunit g, mitochondrial", "refseq_ac": [ { "id": "NP_001019721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019721", "type": "external" } ], "gene_names_uniprotkb": "ATP5MG; ATP5L", "gene_names_refseq": "ATP5L; ATP5MG", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit g, mitochondrial; ATP synthase membrane subunit g; ATPase subunit g", "protein_names_refseq": "ATP synthase F(0) complex subunit g, mitochondrial; ATP synthase subunit g, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G; ATP synthase, H+ transporting, mitochondrial Fo complex subunit G; ATPase subunit g; F1Fo-ATP synthase complex Fo membrane domain g subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:515696)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17570365;8011660", "class_list": "", "function": "Subunit g, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0C5", "ec_number_list": [], "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28852-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29432-1", "uniprot_id": [ { "id": "PAG1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29432", "type": "external" } ], "mass": 42847.0, "length": 380, "protein_name": "Pregnancy-associated glycoprotein 1", "gene_name": "", "organism": "Bovine", "refseq_name": "pregnancy-associated glycoprotein 1 precursor", "refseq_ac": [ { "id": "NP_776836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776836", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "LOC281964; PAG1B; PAG1", "protein_names_uniprotkb": "Pregnancy-associated glycoprotein 1; 3.4.23.-; PAG 1; PSP-B; Pregnancy-specific protein B", "protein_names_refseq": "PAG 1; PSP-B; pregnancy-associated glycoprotein 1 precursor; pregnancy-specific protein B", "tax_id": 9913, "disease": "", "pathway": " (bta:281964)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15822115;17071780;1946444;21872319;24456132;26936628;27045629;30264614;31958645;7622048", "class_list": "", "function": "A negative energy balance during the peri-implantational period reduces dam IGF-1 but does not alter progesterone or pregnancy-specific protein B (PSPB) or fertility in suckled cows., [RefSeq, PubMed]; Appears to be proteolytically inactive., [UniProtKB]; Restraint stress for 2 h during early pregnancy in heifers increased blood cortisol, but it did not affect the concentrations of progesterone and PAG-1 between days 30 to 40 of gestation., [RefSeq, PubMed]; The clinical implications of these findings are that following infection with N. caninum, most cows will experience some level of placental damage and that this injury correlates with foetal fluid PAG levels and pH., [RefSeq, PubMed]; These findings indicate that IFN-gamma production correlates negatively and the production of antibodies against N. caninum is uncorrelated with plasma pregnancy-associated glycoproteins levels., [RefSeq, PubMed]; This study evaluated the role of PSPB blood levels in predicting multiple pregnancies and pregnancy loss in dairy cattle., [RefSeq, PubMed]; This study examines expression patterns of the genes SERPINA14, PAG, and PAG2 at the fetal-maternal interface in dairy heifers experimentally infected with N caninum during the second trimester of pregnancy, when most abortions takes place in natural conditions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A7YWR8", "ec_number_list": [], "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q29432-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29442-1", "uniprot_id": [ { "id": "CO4A4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29442", "type": "external" } ], "mass": 46385.0, "length": 453, "protein_name": "Collagen alpha-4(IV) chain", "gene_name": "COL4A4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COL4A4", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-4(IV) chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "1370461;1468209;1869555;2318822;2438283", "class_list": "", "function": "Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005604 basement membrane;GO:0005587 collagen type IV trimer", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q29442-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29443-1", "uniprot_id": [ { "id": "TRFE_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29443", "type": "external" } ], "mass": 77753.0, "length": 704, "protein_name": "Serotransferrin", "gene_name": "TF", "organism": "Bovine", "refseq_name": "serotransferrin precursor", "refseq_ac": [ { "id": "NP_803450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803450", "type": "external" } ], "gene_names_uniprotkb": "TF", "gene_names_refseq": "TF", "protein_names_uniprotkb": "Serotransferrin; Beta-1 metal-binding globulin; Siderophilin; Transferrin", "protein_names_refseq": "beta-1 metal-binding globulin; serotransferrin precursor; serotransferrin; siderophilin", "tax_id": 9913, "disease": "", "pathway": " (bta:280705)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10233671;11801660;12391225;12648094;18512783;20449817;21209280;26495903;30573663;32366593;8315383;8557646", "class_list": "", "function": "The TF gene has an effect on milk fat yield. Publication Status: Online-Only, [RefSeq, PubMed]; Transferrin Binding Protein B and Transferrin Binding Protein A2 Expand the Transferrin Recognition Range of Histophilus somni. Publication Status: Online-Only, [RefSeq, PubMed]; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0IIK2", "ec_number_list": [], "go_molecular_function": "GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0006879 intracellular iron ion homeostasis;GO:0006826 iron ion transport;GO:0051241 negative regulation of multicellular organismal process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q29443-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29458-1", "uniprot_id": [ { "id": "LIPF_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29458", "type": "external" } ], "mass": 45231.0, "length": 397, "protein_name": "Gastric triacylglycerol lipase", "gene_name": "LIPF", "organism": "Bovine", "refseq_name": "gastric triacylglycerol lipase precursor", "refseq_ac": [ { "id": "NP_776528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776528", "type": "external" } ], "gene_names_uniprotkb": "LIPF", "gene_names_refseq": "LIPF", "protein_names_uniprotkb": "Gastric triacylglycerol lipase; 3.1.1.3; GL; Gastric lipase; PGE; Pregastric esterase", "protein_names_refseq": "GL; PGE; gastric lipase; gastric triacylglycerol lipase precursor; gastric triacylglycerol lipase; lipase, gastric; pregastric esterase", "tax_id": 9913, "disease": "", "pathway": " (bta:281283)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7926811;8615791", "class_list": "", "function": "Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:8615791). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q29458-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29461-1", "uniprot_id": [ { "id": "CEL2A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29461", "type": "external" } ], "mass": 28857.0, "length": 269, "protein_name": "Chymotrypsin-like elastase family member 2A", "gene_name": "CELA2A", "organism": "Bovine", "refseq_name": "chymotrypsin-like elastase family member 2A precursor", "refseq_ac": [ { "id": "NP_777139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777139", "type": "external" } ], "gene_names_uniprotkb": "CELA2A; ELA2A; ELA2", "gene_names_refseq": "CELA2A; ELA2A; Ela2", "protein_names_uniprotkb": "Chymotrypsin-like elastase family member 2A; 3.4.21.71; Elastase II; Elastase-2A; Elastase-2", "protein_names_refseq": "chymotrypsin-like elastase family member 2A precursor; elastase 2A; elastase 2; elastase II", "tax_id": 9913, "disease": "", "pathway": " (bta:282687)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9418008", "class_list": "", "function": "Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0050796 regulation of insulin secretion;GO:0032868 response to insulin;GO:1901143 insulin catabolic process;GO:0090330 regulation of platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q29461-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29463-1", "uniprot_id": [ { "id": "TRY2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29463", "type": "external" } ], "mass": 26290.0, "length": 247, "protein_name": "Anionic trypsin", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Anionic trypsin; 3.4.21.4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1701147;17087724", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q29463-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29465-1", "uniprot_id": [ { "id": "SYYC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29465", "type": "external" } ], "mass": 59149.0, "length": 528, "protein_name": "Tyrosine--tRNA ligase, cytoplasmic", "gene_name": "YARS1", "organism": "Bovine", "refseq_name": "tyrosine--tRNA ligase, cytoplasmic", "refseq_ac": [ { "id": "NP_776645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776645", "type": "external" } ], "gene_names_uniprotkb": "YARS1; TYRS; YARS", "gene_names_refseq": "YARS1; YARS; tyrS", "protein_names_uniprotkb": "Tyrosine--tRNA ligase, cytoplasmic; 6.1.1.1; TyrRS; Tyrosyl-tRNA synthetase", "protein_names_refseq": "tyrRS; tyrosine--tRNA ligase, cytoplasmic; tyrosyl--tRNA ligase; tyrosyl-tRNA synthetase, cytoplasmic", "tax_id": 9913, "disease": "", "pathway": " (bta:281581)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16955364", "class_list": "", "function": "Conformational transition of Trp144 from buried native state into highly relaxing polar solvent environment, [RefSeq, PubMed]; Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9TSJ1", "ec_number_list": [ { "id": "6.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0036094 small molecule binding;GO:0004831 tyrosine-tRNA ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006950 response to stress;GO:0006437 tyrosyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q29465-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RI0-1", "uniprot_id": [ { "id": "COQ8A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RI0", "type": "external" } ], "mass": 72082.0, "length": 648, "protein_name": "Atypical kinase COQ8A, mitochondrial", "gene_name": "COQ8A", "organism": "Bovine", "refseq_name": "atypical kinase COQ8A, mitochondrial", "refseq_ac": [ { "id": "NP_001039884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039884", "type": "external" } ], "gene_names_uniprotkb": "COQ8A; ADCK3; CABC1", "gene_names_refseq": "ADCK3; CABC1; COQ8A", "protein_names_uniprotkb": "Atypical kinase COQ8A, mitochondrial; 2.7.-.-; Chaperone activity of bc1 complex-like; Chaperone-ABC1-like; Coenzyme Q protein 8A; aarF domain-containing protein kinase 3", "protein_names_refseq": "aarF domain containing kinase 3; aarF domain-containing protein kinase 3; atypical kinase ADCK3, mitochondrial; atypical kinase COQ8A, mitochondrial; chaperone activity of bc1 complex-like, mitochondrial; chaperone, ABC1 activity of bc1 complex homolog; chaperone, ABC1 activity of bc1 complex like; coenzyme Q protein 8A", "tax_id": 9913, "disease": "", "pathway": " (bta:536925); (R-BTA-2142789)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (By similarity). Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3 (By similarity). According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (By similarity). However, the small molecule kinase activity was not confirmed by another publication (By similarity). Shows an unusual selectivity for binding ADP over ATP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8G9", "ec_number_list": [ { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0008047 enzyme activator activity;GO:0043531 ADP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0016310 phosphorylation;GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q29RI0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RK4-1", "uniprot_id": [ { "id": "RD23B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RK4", "type": "external" } ], "mass": 43117.0, "length": 408, "protein_name": "Lysine-specific demethylase RAD23B", "gene_name": "RAD23B", "organism": "Bovine", "refseq_name": "lysine-specific demethylase RAD23B", "refseq_ac": [ { "id": "NP_001039775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039775", "type": "external" } ], "gene_names_uniprotkb": "RAD23B", "gene_names_refseq": "RAD23B", "protein_names_uniprotkb": "Lysine-specific demethylase RAD23B; 1.14.11.-; UV excision repair protein RAD23 homolog B", "protein_names_refseq": "UV excision repair protein RAD23 homolog B; lysine-specific demethylase RAD23B", "tax_id": 9913, "disease": "", "pathway": " (bta:530189); (R-BTA-532668); (R-BTA-5689877); (R-BTA-5696394); (R-BTA-5696395)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation and transcriptional regulation. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3. Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex, a nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA. Recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix including single-stranded loops, mismatched bubbles or single-stranded overhangs. Cooperatively with CETN2 appears to stabilize XPC., [UniProtKB, UniProtKB]; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.5.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.52", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" } ], "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0003684 damaged DNA binding;GO:0043130 ubiquitin binding;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex;GO:0071942 XPC complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RK4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RM5-1", "uniprot_id": [ { "id": "FEM1A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RM5", "type": "external" } ], "mass": 72100.0, "length": 653, "protein_name": "Protein fem-1 homolog A", "gene_name": "FEM1A", "organism": "Bovine", "refseq_name": "protein fem-1 homolog A", "refseq_ac": [ { "id": "NP_001039691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039691", "type": "external" } ], "gene_names_uniprotkb": "FEM1A", "gene_names_refseq": "FEM1A", "protein_names_uniprotkb": "Protein fem-1 homolog A; FEM1-alpha; FEM1a", "protein_names_refseq": "FEM1-alpha; protein fem-1 homolog A", "tax_id": 9913, "disease": "", "pathway": " (bta:516550); (R-BTA-8951664)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (By similarity). Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031867 EP4 subtype prostaglandin E2 receptor binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0000151 ubiquitin ligase complex;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050729 positive regulation of inflammatory response;GO:0016567 protein ubiquitination;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RM5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RP1-1", "uniprot_id": [ { "id": "UBP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RP1", "type": "external" } ], "mass": 88459.0, "length": 783, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 1", "gene_name": "USP1", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 1", "refseq_ac": [ { "id": "NP_001039689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039689", "type": "external" } ], "gene_names_uniprotkb": "USP1", "gene_names_refseq": "USP1", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 1; 3.4.19.12; Deubiquitinating enzyme 1; Ubiquitin thioesterase 1; Ubiquitin-specific-processing protease 1", "protein_names_refseq": "deubiquitinating enzyme 1; ubiquitin carboxyl-terminal hydrolase 1; ubiquitin thioesterase 1; ubiquitin thiolesterase 1; ubiquitin-specific-processing protease 1", "tax_id": 9913, "disease": "", "pathway": " (bta:516328)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0009411 response to UV", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RP1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RQ3-1", "uniprot_id": [ { "id": "DC1I1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RQ3", "type": "external" } ], "mass": 68556.0, "length": 608, "protein_name": "Cytoplasmic dynein 1 intermediate chain 1", "gene_name": "DYNC1I1", "organism": "Bovine", "refseq_name": "cytoplasmic dynein 1 intermediate chain 1", "refseq_ac": [ { "id": "NP_001039981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039981", "type": "external" } ], "gene_names_uniprotkb": "DYNC1I1", "gene_names_refseq": "DH IC-1; DYNC1I1", "protein_names_uniprotkb": "Cytoplasmic dynein 1 intermediate chain 1; Cytoplasmic dynein intermediate chain 1; DH IC-1; Dynein intermediate chain 1, cytosolic", "protein_names_refseq": "cytoplasmic dynein 1 intermediate chain 1; cytoplasmic dynein intermediate chain 1; dynein intermediate chain 1, cytosolic", "tax_id": 9913, "disease": "", "pathway": " (bta:613724); (R-BTA-141430); (R-BTA-141444); (R-BTA-2132295); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-3371497); (R-BTA-5663220); (R-BTA-6807878); (R-BTA-6811436); (R-BTA-9646399); (R-BTA-9648025)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "11967380", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0031982 vesicle;GO:0000776 kinetochore", "go_biological_process": "GO:0010970 transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q29RQ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RT1-1", "uniprot_id": [ { "id": "LYZL6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RT1", "type": "external" } ], "mass": 16559.0, "length": 148, "protein_name": "Lysozyme-like protein 6", "gene_name": "LYZL6", "organism": "Bovine", "refseq_name": "lysozyme-like protein 6 precursor", "refseq_ac": [ { "id": "NP_001039931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039931", "type": "external" } ], "gene_names_uniprotkb": "LYZL6", "gene_names_refseq": "LYZB; LYZL6", "protein_names_uniprotkb": "Lysozyme-like protein 6; 3.2.1.17", "protein_names_refseq": "lysozyme B; lysozyme-like protein 6 precursor; lysozyme-like protein 6", "tax_id": 9913, "disease": "", "pathway": " (bta:540048)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0097524 sperm plasma membrane", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0009566 fertilization;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RT1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RU0-1", "uniprot_id": [ { "id": "RN128_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RU0", "type": "external" } ], "mass": 46881.0, "length": 431, "protein_name": "E3 ubiquitin-protein ligase RNF128", "gene_name": "RNF128", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase RNF128 precursor", "refseq_ac": [ { "id": "NP_001069539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069539", "type": "external" } ], "gene_names_uniprotkb": "RNF128", "gene_names_refseq": "RNF128", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF128; 2.3.2.27; RING finger protein 128; RING-type E3 ubiquitin transferase RNF128", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF128 precursor; E3 ubiquitin-protein ligase RNF128; RING-type E3 ubiquitin transferase RNF128; ring finger protein 128, E3 ubiquitin protein ligase", "tax_id": 9913, "disease": "", "pathway": " (bta:535869)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that catalyzes 'Lys-27', 'Lys-48'- or 'Lys-63'-linked polyubiquitin chains formation and plays a role in different biological processes such as modulation of immune response, cytoskeletal dynamics or protein homeostasis. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytoskeletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. Plays a positive role in innate immune response by promoting 'Lys-63'-linked ubiquitination of TBK1 after RNA- or DNA-virus infection. Regulates alveolar macrophage activation and neutrophil infiltration by interacting with TLR4, targeting it for degradation, and inhibiting NF-kappa-B activation, hence decreasing pro-inflammatory cytokines. Negatively regulates the IL-3/STAT5 signaling pathway by facilitating 'Lys-27'-linked polyubiquitination of IL3RA leading to its degradation via lysosomal pathway. Directly regulates the N-glycosylation process in the endoplasmic reticulum by targeting the glycosyl-transferase RPN1 for ubiquitination and degradation. Other substrates targeted for degradation by RNF128 include transmembrane proteins CD40L, CD83 or the tetraspanin CD151., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RU0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RZ0-1", "uniprot_id": [ { "id": "THIL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RZ0", "type": "external" } ], "mass": 44889.0, "length": 422, "protein_name": "Acetyl-CoA acetyltransferase, mitochondrial", "gene_name": "ACAT1", "organism": "Bovine", "refseq_name": "acetyl-CoA acetyltransferase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001039540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039540", "type": "external" } ], "gene_names_uniprotkb": "ACAT1", "gene_names_refseq": "ACAT1", "protein_names_uniprotkb": "Acetyl-CoA acetyltransferase, mitochondrial; 2.3.1.9; Acetoacetyl-CoA thiolase", "protein_names_refseq": "acetoacetyl-CoA thiolase; acetyl-CoA acetyltransferase, mitochondrial precursor; acetyl-CoA acetyltransferase, mitochondrial; acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)", "tax_id": 9913, "disease": "", "pathway": " (bta:511082); (R-BTA-70895); (R-BTA-77108); (R-BTA-77111); (R-BTA-9837999); (R-BTA-9854311)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "27611366", "class_list": "", "function": "The transcript abundance of ACAT1 was increased in the more efficient low residual feed intake (RFI) animals and decreased in the less efficient high RFI animals, [RefSeq, PubMed]; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003985 acetyl-CoA C-acetyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q29RZ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RZ2-1", "uniprot_id": [ { "id": "PPWD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RZ2", "type": "external" } ], "mass": 73274.0, "length": 644, "protein_name": "Peptidylprolyl isomerase domain and WD repeat-containing protein 1", "gene_name": "PPWD1", "organism": "Bovine", "refseq_name": "peptidylprolyl isomerase domain and WD repeat-containing protein 1", "refseq_ac": [ { "id": "NP_001039696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039696", "type": "external" } ], "gene_names_uniprotkb": "PPWD1", "gene_names_refseq": "PPWD1", "protein_names_uniprotkb": "Peptidylprolyl isomerase domain and WD repeat-containing protein 1; 5.2.1.8", "protein_names_refseq": "peptidylprolyl isomerase domain and WD repeat-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:517560); (R-BTA-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0016604 nuclear body;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RZ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ17-1", "uniprot_id": [ { "id": "CCR5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ17", "type": "external" } ], "mass": 40235.0, "length": 352, "protein_name": "C-C chemokine receptor type 5", "gene_name": "CCR5", "organism": "Bovine", "refseq_name": "C-C chemokine receptor type 5", "refseq_ac": [ { "id": "NP_001011672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011672", "type": "external" } ], "gene_names_uniprotkb": "CCR5; CMKBR5", "gene_names_refseq": "CCR5", "protein_names_uniprotkb": "C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5", "protein_names_refseq": "C-C CKR-5; C-C chemokine receptor type 5; CC-CKR-5; CCR-5; chemokine C-C motif receptor 5", "tax_id": 9913, "disease": "", "pathway": " (bta:497017); (R-BTA-380108); (R-BTA-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16762412", "class_list": "", "function": "Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor., [UniProtKB, UniProtKB]; Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CCR5 expression., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5MD63", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0016493 C-C chemokine receptor activity;GO:0042802 identical protein binding;GO:0071791 chemokine (C-C motif) ligand 5 binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2HJ17-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ18-1", "uniprot_id": [ { "id": "VP33B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ18", "type": "external" } ], "mass": 70659.0, "length": 617, "protein_name": "Vacuolar protein sorting-associated protein 33B", "gene_name": "VPS33B", "organism": "Bovine", "refseq_name": "vacuolar protein sorting-associated protein 33B", "refseq_ac": [ { "id": "NP_001039749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039749", "type": "external" } ], "gene_names_uniprotkb": "VPS33B", "gene_names_refseq": "VPS33B", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 33B", "protein_names_refseq": "vacuolar protein sorting 33B); vacuolar protein sorting-associated protein 33B", "tax_id": 9913, "disease": "", "pathway": " (bta:526538)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L527", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome", "go_biological_process": "GO:0070889 platelet alpha granule organization;GO:0006886 intracellular protein transport;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0061025 membrane fusion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2HJ18-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ21-1", "uniprot_id": [ { "id": "MDM4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ21", "type": "external" } ], "mass": 55180.0, "length": 491, "protein_name": "Protein Mdm4", "gene_name": "MDM4", "organism": "Bovine", "refseq_name": "protein Mdm4", "refseq_ac": [ { "id": "NP_001039634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039634", "type": "external" } ], "gene_names_uniprotkb": "MDM4; MDMX", "gene_names_refseq": "MDM4", "protein_names_uniprotkb": "Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4", "protein_names_refseq": "MDM4, p53 regulator; Mdm4 p53 binding protein homolog; Mdm4, transformed 3T3 cell double minute 4, p53 binding protein; double minute 4 homolog; double minute 4 protein; mdm2-like p53-binding protein; p53-binding protein Mdm4; protein Mdm4; protein Mdmx", "tax_id": 9913, "disease": "", "pathway": " (bta:514225)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Contributes to p53/TP53 regulation. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0050821 protein stabilization;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ21-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ58-1", "uniprot_id": [ { "id": "PRPS1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ58", "type": "external" } ], "mass": 34834.0, "length": 318, "protein_name": "Ribose-phosphate pyrophosphokinase 1", "gene_name": "PRPS1", "organism": "Bovine", "refseq_name": "ribose-phosphate pyrophosphokinase 1", "refseq_ac": [ { "id": "NP_001039654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039654", "type": "external" } ], "gene_names_uniprotkb": "PRPS1", "gene_names_refseq": "PRPS1; PRS-I", "protein_names_uniprotkb": "Ribose-phosphate pyrophosphokinase 1; 2.7.6.1; PRS-I; Phosphoribosyl pyrophosphate synthase I", "protein_names_refseq": "phosphoribosyl pyrophosphate synthase I; phosphoribosyl pyrophosphate synthetase I; ribose-phosphate pyrophosphokinase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:781227); (R-BTA-73843)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PKB5", "ec_number_list": [ { "id": "2.7.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.6.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0016301 kinase activity;GO:0004749 ribose phosphate diphosphokinase activity", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0009156 ribonucleoside monophosphate biosynthetic process;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ58-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ68-1", "uniprot_id": [ { "id": "RND1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ68", "type": "external" } ], "mass": 26029.0, "length": 232, "protein_name": "Rho-related GTP-binding protein Rho6", "gene_name": "RND1", "organism": "Bovine", "refseq_name": "rho-related GTP-binding protein Rho6", "refseq_ac": [ { "id": "NP_001039481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039481", "type": "external" } ], "gene_names_uniprotkb": "RND1; RHO6", "gene_names_refseq": "RND1", "protein_names_uniprotkb": "Rho-related GTP-binding protein Rho6; 3.6.5.2; Rho family GTPase 1; Rnd1", "protein_names_refseq": "rho-related GTP-binding protein Rho6", "tax_id": 9913, "disease": "", "pathway": " (bta:508869); (R-BTA-416550); (R-BTA-416572); (R-BTA-9696273)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005102 signaling receptor binding;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0007162 negative regulation of cell adhesion;GO:0007165 signal transduction;GO:0016322 neuron remodeling;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ68-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ74-1", "uniprot_id": [ { "id": "GATM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ74", "type": "external" } ], "mass": 48357.0, "length": 423, "protein_name": "Glycine amidinotransferase, mitochondrial", "gene_name": "GATM", "organism": "Bovine", "refseq_name": "glycine amidinotransferase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001039343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039343", "type": "external" } ], "gene_names_uniprotkb": "GATM", "gene_names_refseq": "GATM", "protein_names_uniprotkb": "Glycine amidinotransferase, mitochondrial; 2.1.4.1; L-arginine:glycine amidinotransferase; Transamidinase", "protein_names_refseq": "L-arginine:glycine amidinotransferase; glycine amidinotransferase, mitochondrial precursor; glycine amidinotransferase, mitochondrial; transamidinase", "tax_id": 9913, "disease": "", "pathway": " (bta:414732); (R-BTA-71288)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.4.1", "type": "external" } ], "go_molecular_function": "GO:0015067 amidinotransferase activity;GO:0015068 glycine amidinotransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0007611 learning or memory;GO:0006601 creatine biosynthetic process;GO:0014889 muscle atrophy;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ74-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJC9-1", "uniprot_id": [ { "id": "PQBP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJC9", "type": "external" } ], "mass": 30346.0, "length": 263, "protein_name": "Polyglutamine-binding protein 1", "gene_name": "PQBP1", "organism": "Bovine", "refseq_name": "polyglutamine-binding protein 1", "refseq_ac": [ { "id": "NP_001039854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039854", "type": "external" } ], "gene_names_uniprotkb": "PQBP1", "gene_names_refseq": "PQBP1", "protein_names_uniprotkb": "Polyglutamine-binding protein 1; PQBP-1; Polyglutamine tract-binding protein 1", "protein_names_refseq": "PQBP-1; polyglutamine tract-binding protein 1; polyglutamine-binding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:534894); (R-BTA-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body;GO:0120025 plasma membrane bounded cell projection", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0006351 DNA-templated transcription;GO:0031175 neuron projection development;GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJC9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJD1-1", "uniprot_id": [ { "id": "LMA2L_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJD1", "type": "external" } ], "mass": 39991.0, "length": 348, "protein_name": "VIP36-like protein", "gene_name": "LMAN2L", "organism": "Bovine", "refseq_name": "VIP36-like protein precursor", "refseq_ac": [ { "id": "NP_001014953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014953", "type": "external" } ], "gene_names_uniprotkb": "LMAN2L; VIPL", "gene_names_refseq": "LMAN2L", "protein_names_uniprotkb": "VIP36-like protein; LMAN2-like protein; Lectin mannose-binding 2-like", "protein_names_refseq": "LMAN2-like protein; VIP36-like protein precursor; VIP36-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:539289); (R-BTA-204005); (R-BTA-5694530)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5BIS5", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005537 D-mannose binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2HJD1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJG3-1", "uniprot_id": [ { "id": "RHOH_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJG3", "type": "external" } ], "mass": 21260.0, "length": 191, "protein_name": "Rho-related GTP-binding protein RhoH", "gene_name": "RHOH", "organism": "Bovine", "refseq_name": "rho-related GTP-binding protein RhoH", "refseq_ac": [ { "id": "NP_001071592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071592", "type": "external" } ], "gene_names_uniprotkb": "RHOH", "gene_names_refseq": "RHOH", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoH; 3.6.5.2", "protein_names_refseq": "ras homolog gene family, member H; rho-related GTP-binding protein RhoH", "tax_id": 9913, "disease": "", "pathway": " (bta:768307)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils. Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJG3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJH2-1", "uniprot_id": [ { "id": "RAB1B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJH2", "type": "external" } ], "mass": 22202.0, "length": 201, "protein_name": "Ras-related protein Rab-1B", "gene_name": "RAB1B", "organism": "Bovine", "refseq_name": "ras-related protein Rab-1B", "refseq_ac": [ { "id": "NP_001069701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069701", "type": "external" } ], "gene_names_uniprotkb": "RAB1B", "gene_names_refseq": "RAB1B", "protein_names_uniprotkb": "Ras-related protein Rab-1B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-1B", "tax_id": 9913, "disease": "", "pathway": " (bta:540685)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system;GO:0034045 phagophore assembly site membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJH2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJI8-1", "uniprot_id": [ { "id": "RAB8B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJI8", "type": "external" } ], "mass": 23656.0, "length": 207, "protein_name": "Ras-related protein Rab-8B", "gene_name": "RAB8B", "organism": "Bovine", "refseq_name": "ras-related protein Rab-8B", "refseq_ac": [ { "id": "NP_001069785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069785", "type": "external" } ], "gene_names_uniprotkb": "RAB8B", "gene_names_refseq": "RAB8B", "protein_names_uniprotkb": "Ras-related protein Rab-8B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-8B", "tax_id": 9913, "disease": "", "pathway": " (bta:614242)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB8B may be involved in polarized vesicular trafficking and neurotransmitter release (By similarity). May participate in cell junction dynamics in Sertoli cells (By similarity). May also participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0030670 phagocytic vesicle membrane;GO:0010008 endosome membrane;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJI8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KHW5-1", "uniprot_id": [ { "id": "ACBG1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KHW5", "type": "external" } ], "mass": 80585.0, "length": 726, "protein_name": "Long-chain-fatty-acid--CoA ligase ACSBG1", "gene_name": "ACSBG1", "organism": "Bovine", "refseq_name": "long-chain-fatty-acid--CoA ligase ACSBG1", "refseq_ac": [ { "id": "NP_001019719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019719", "type": "external" } ], "gene_names_uniprotkb": "ACSBG1", "gene_names_refseq": "ACSBG1; BG1", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase ACSBG1; 6.2.1.3; Acyl-CoA synthetase bubblegum family member 1", "protein_names_refseq": "lipidosin; long-chain-fatty-acid--CoA ligase ACSBG1", "tax_id": 9913, "disease": "", "pathway": " (bta:515577)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58CT3", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0016020 membrane", "go_biological_process": "GO:0042759 long-chain fatty acid biosynthetic process;GO:0000038 very long-chain fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KHW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KHY1-1", "uniprot_id": [ { "id": "CPNE6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KHY1", "type": "external" } ], "mass": 61865.0, "length": 557, "protein_name": "Copine-6", "gene_name": "CPNE6", "organism": "Bovine", "refseq_name": "copine-6", "refseq_ac": [ { "id": "NP_001039455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039455", "type": "external" } ], "gene_names_uniprotkb": "CPNE6", "gene_names_refseq": "CPNE6", "protein_names_uniprotkb": "Copine-6; Copine VI", "protein_names_refseq": "copine VI (neuronal); copine-6", "tax_id": 9913, "disease": "", "pathway": " (bta:508059); (R-BTA-1483206)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0030154 cell differentiation;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KHY1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KI42-1", "uniprot_id": [ { "id": "PSD11_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KI42", "type": "external" } ], "mass": 47464.0, "length": 422, "protein_name": "26S proteasome non-ATPase regulatory subunit 11", "gene_name": "PSMD11", "organism": "Bovine", "refseq_name": "26S proteasome non-ATPase regulatory subunit 11", "refseq_ac": [ { "id": "NP_001039613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039613", "type": "external" } ], "gene_names_uniprotkb": "PSMD11", "gene_names_refseq": "PSMD11", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit RPN6", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit RPN6; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11; proteasome 26S non-ATPase subunit 11", "tax_id": 9913, "disease": "", "pathway": " (bta:513461); (R-BTA-1169091); (R-BTA-1234176); (R-BTA-1236978); (R-BTA-174084); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-187577); (R-BTA-195253); (R-BTA-202424); (R-BTA-2467813); (R-BTA-2871837); (R-BTA-349425); (R-BTA-350562); (R-BTA-382556); (R-BTA-450408); (R-BTA-4608870); (R-BTA-4641257); (R-BTA-4641258); (R-BTA-5358346); (R-BTA-5607761); (R-BTA-5607764); (R-BTA-5610780); (R-BTA-5610785); (R-BTA-5632684); (R-BTA-5668541); (R-BTA-5676590); (R-BTA-5687128); (R-BTA-5689603); (R-BTA-5689880); (R-BTA-6798695); (R-BTA-68867); (R-BTA-68949); (R-BTA-69017); (R-BTA-69481); (R-BTA-69601); (R-BTA-75815); (R-BTA-8852276); (R-BTA-8854050); (R-BTA-8939236); (R-BTA-8939902); (R-BTA-8941858); (R-BTA-8948751); (R-BTA-8951664); (R-BTA-9020702); (R-BTA-9755511); (R-BTA-9762114); (R-BTA-9766229); (R-BTA-983168); (R-BTA-9907900); (R-BTA-9929356); (R-BTA-9929491); (R-BTA-9931269); (R-BTA-9932298); (R-BTA-9954709)", "pathway_count": 56, "publication_count": 2, "publication_id_list": "12140684;19393038", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L5A1;F1MXM5", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0008541 proteasome regulatory particle, lid subcomplex;GO:0005838 proteasome regulatory particle", "go_biological_process": "GO:0048863 stem cell differentiation;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2KI42-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KI43-1", "uniprot_id": [ { "id": "CAV3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KI43", "type": "external" } ], "mass": 17362.0, "length": 151, "protein_name": "Caveolin-3", "gene_name": "CAV3", "organism": "Bovine", "refseq_name": "caveolin-3", "refseq_ac": [ { "id": "NP_001040023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040023", "type": "external" } ], "gene_names_uniprotkb": "CAV3", "gene_names_refseq": "CAV3", "protein_names_uniprotkb": "Caveolin-3", "protein_names_refseq": "caveolin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:615310)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a scaffolding protein within caveolar membranes. Interacts directly with G protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071253 connexin binding;GO:0060090 molecular adaptor activity;GO:0005246 calcium channel regulator activity;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005901 caveola;GO:0042383 sarcolemma", "go_biological_process": "GO:0035995 detection of muscle stretch;GO:0060299 negative regulation of sarcomere organization;GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:0090279 regulation of calcium ion import;GO:1900826 negative regulation of membrane depolarization during cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KI43-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KI51-1", "uniprot_id": [ { "id": "PR15A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KI51", "type": "external" } ], "mass": 73053.0, "length": 670, "protein_name": "Protein phosphatase 1 regulatory subunit 15A", "gene_name": "PPP1R15A", "organism": "Bovine", "refseq_name": "protein phosphatase 1 regulatory subunit 15A", "refseq_ac": [ { "id": "NP_001039643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039643", "type": "external" } ], "gene_names_uniprotkb": "PPP1R15A; GADD34", "gene_names_refseq": "PPP1R15A", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 15A; Growth arrest and DNA damage-inducible protein GADD34", "protein_names_refseq": "growth arrest and DNA damage-inducible protein GADD34; protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A", "tax_id": 9913, "disease": "", "pathway": " (bta:514688)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006417 regulation of translation;GO:0006915 apoptotic process;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KI51-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KI84-1", "uniprot_id": [ { "id": "HARS1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KI84", "type": "external" } ], "mass": 57285.0, "length": 509, "protein_name": "Histidine--tRNA ligase, cytoplasmic", "gene_name": "HARS1", "organism": "Bovine", "refseq_name": "histidine--tRNA ligase, cytoplasmic", "refseq_ac": [ { "id": "NP_001039531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039531", "type": "external" } ], "gene_names_uniprotkb": "HARS1; HARS", "gene_names_refseq": "HARS1; HARSL; HARS", "protein_names_uniprotkb": "Histidine--tRNA ligase, cytoplasmic; 6.1.1.21; HisRS; Histidyl-tRNA synthetase", "protein_names_refseq": "hisRS; histidine--tRNA ligase, cytoplasmic; histidyl-tRNA synthetase, cytoplasmic", "tax_id": 9913, "disease": "", "pathway": " (bta:510937)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.21", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0004821 histidine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006427 histidyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KI84-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIA4-1", "uniprot_id": [ { "id": "SCD5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIA4", "type": "external" } ], "mass": 38215.0, "length": 335, "protein_name": "Stearoyl-CoA desaturase 5", "gene_name": "SCD5", "organism": "Bovine", "refseq_name": "stearoyl-CoA desaturase 5", "refseq_ac": [ { "id": "NP_001070413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070413", "type": "external" } ], "gene_names_uniprotkb": "SCD5", "gene_names_refseq": "SCD5", "protein_names_uniprotkb": "Stearoyl-CoA desaturase 5; 1.14.19.1; Acyl-CoA-desaturase 4; Stearoyl-CoA 9-desaturase", "protein_names_refseq": "acyl-CoA-desaturase 4; stearoyl-CoA 9-desaturase; stearoyl-CoA desaturase 5", "tax_id": 9913, "disease": "", "pathway": " (bta:617419); (R-BTA-75105)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17468887;22510410;25899038", "class_list": "", "function": "In this paper, we describe for the first time a second SCD isoform in cattle, which appears to be an ortholog of human SCD5 rather than a homolog of bovine SCD1 or any of the described murine SCD isoforms, [RefSeq, PubMed]; Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways., [UniProtKB, UniProtKB]; This is the first report of potential regulators of SCD5 transcription., [RefSeq, PubMed]; This is the first study examining a potential role for SCD5 in providing 18:1n-9 for brain lipids., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.1", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0004768 stearoyl-CoA 9-desaturase activity;GO:0016491 oxidoreductase activity;GO:0032896 palmitoyl-CoA 9-desaturase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006636 unsaturated fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2KIA4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KID2-1", "uniprot_id": [ { "id": "NTH_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KID2", "type": "external" } ], "mass": 33645.0, "length": 305, "protein_name": "Endonuclease III-like protein 1", "gene_name": "NTHL1", "organism": "Bovine", "refseq_name": "endonuclease III-like protein 1", "refseq_ac": [ { "id": "NP_001039862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039862", "type": "external" } ], "gene_names_uniprotkb": "NTHL1", "gene_names_refseq": "NTHL1", "protein_names_uniprotkb": "Endonuclease III-like protein 1; 3.2.2.-; 4.2.99.18; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; DNA glycosylase/AP lyase", "protein_names_refseq": "DNA glycoslyase/AP lyase; DNA glycosylase/AP lyase; bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase; bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; endonuclease III-like protein 1; nth endonuclease III-like 1", "tax_id": 9913, "disease": "", "pathway": " (bta:535203); (R-BTA-110329); (R-BTA-110357)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M5FK15", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006289 nucleotide-excision repair;GO:0006285 base-excision repair, AP site formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KID2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIE2-1", "uniprot_id": [ { "id": "HAX1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIE2", "type": "external" } ], "mass": 31415.0, "length": 279, "protein_name": "HCLS1-associated protein X-1", "gene_name": "HAX1", "organism": "Bovine", "refseq_name": "HCLS1-associated protein X-1", "refseq_ac": [ { "id": "NP_001039418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039418", "type": "external" } ], "gene_names_uniprotkb": "HAX1", "gene_names_refseq": "HAX-1; HAX1", "protein_names_uniprotkb": "HCLS1-associated protein X-1; HAX-1; HS1-associating protein X-1", "protein_names_refseq": "HCLS1-associated protein X-1; HS1-associating protein X-1", "tax_id": 9913, "disease": "", "pathway": " (bta:506895)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton;GO:0031965 nuclear membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0038158 granulocyte colony-stimulating factor signaling pathway;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIE2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIF8-1", "uniprot_id": [ { "id": "SYCM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIF8", "type": "external" } ], "mass": 61199.0, "length": 555, "protein_name": "Cysteine--tRNA ligase, mitochondrial", "gene_name": "CARS2", "organism": "Bovine", "refseq_name": "cysteine--tRNA ligase, mitochondrial", "refseq_ac": [ { "id": "NP_001039409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039409", "type": "external" } ], "gene_names_uniprotkb": "CARS2", "gene_names_refseq": "CARS2", "protein_names_uniprotkb": "Cysteine--tRNA ligase, mitochondrial; 6.1.1.16; CysRS; Cysteinyl-tRNA synthetase", "protein_names_refseq": "cysRS; cysteine--tRNA ligase, mitochondrial-like; cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial (putative); cysteinyl-tRNA synthetase, mitochondrial; probable cysteinyl-tRNA synthetase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:506598)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants., [UniProtKB, UniProtKB]; Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.16", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004817 cysteine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006423 cysteinyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIF8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIG5-1", "uniprot_id": [ { "id": "THAS_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIG5", "type": "external" } ], "mass": 60539.0, "length": 533, "protein_name": "Thromboxane-A synthase", "gene_name": "TBXAS1", "organism": "Bovine", "refseq_name": "thromboxane-A synthase", "refseq_ac": [ { "id": "NP_001039492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039492", "type": "external" } ], "gene_names_uniprotkb": "TBXAS1; CYP5A1", "gene_names_refseq": "TBXAS1", "protein_names_uniprotkb": "Thromboxane-A synthase; 4.2.1.152; 5.3.99.5; Cytochrome P450 5A1; Hydroperoxy icosatetraenoate dehydratase; TXA synthase; TXS", "protein_names_refseq": "TXA synthase; TXS; cytochrome P450 5A1; hydroperoxy icosatetraenoate dehydratase; thromboxane A synthase 1 (platelet); thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A); thromboxane-A synthase", "tax_id": 9913, "disease": "", "pathway": " (bta:509326)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.1", "type": "external" }, { "id": "5.3.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.4", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0004796 thromboxane-A synthase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006690 icosanoid metabolic process;GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIG5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KII6-1", "uniprot_id": [ { "id": "NGDN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KII6", "type": "external" } ], "mass": 35766.0, "length": 315, "protein_name": "Neuroguidin", "gene_name": "NGDN", "organism": "Bovine", "refseq_name": "neuroguidin", "refseq_ac": [ { "id": "NP_001039924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039924", "type": "external" } ], "gene_names_uniprotkb": "NGDN", "gene_names_refseq": "NGDN", "protein_names_uniprotkb": "Neuroguidin; EIF4E-binding protein", "protein_names_refseq": "EIF4E-binding protein; neuroguidin, EIF4E binding protein; neuroguidin", "tax_id": 9913, "disease": "", "pathway": " (bta:539602)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (By similarity). Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030424 axon;GO:0030425 dendrite;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0006417 regulation of translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KII6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIJ2-1", "uniprot_id": [ { "id": "MET18_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIJ2", "type": "external" } ], "mass": 42101.0, "length": 373, "protein_name": "Histidine protein methyltransferase 1 homolog", "gene_name": "METTL18", "organism": "Bovine", "refseq_name": "histidine protein methyltransferase 1 homolog", "refseq_ac": [ { "id": "NP_001073825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073825", "type": "external" } ], "gene_names_uniprotkb": "METTL18", "gene_names_refseq": "ASTP2; C16H1orf156; C1orf156; METTL18", "protein_names_uniprotkb": "Histidine protein methyltransferase 1 homolog; 2.1.1.85; Methyltransferase-like protein 18", "protein_names_refseq": "histidine protein methyltransferase 1 homolog; methyltransferase-like protein 18", "tax_id": 9913, "disease": "", "pathway": " (bta:783955)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation. Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" } ], "go_molecular_function": "GO:0018064 protein-L-histidine N-tele-methyltransferase activity;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:2000232 regulation of rRNA processing;GO:0006417 regulation of translation;GO:0006448 regulation of translational elongation;GO:0018026 peptidyl-lysine monomethylation;GO:0090069 regulation of ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIJ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIQ8-1", "uniprot_id": [ { "id": "CXL10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIQ8", "type": "external" } ], "mass": 11427.0, "length": 102, "protein_name": "C-X-C motif chemokine 10", "gene_name": "CXCL10", "organism": "Bovine", "refseq_name": "C-X-C motif chemokine 10 precursor", "refseq_ac": [ { "id": "NP_001040016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040016", "type": "external" } ], "gene_names_uniprotkb": "CXCL10", "gene_names_refseq": "CXCL10", "protein_names_uniprotkb": "C-X-C motif chemokine 10; Small-inducible cytokine B10", "protein_names_refseq": "C-X-C motif chemokine 10 precursor; C-X-C motif chemokine 10; chemokine (C-X-C motif) ligand 10; gamma interferon inducible protein 10; small-inducible cytokine B10", "tax_id": 9913, "disease": "", "pathway": " (bta:615107); (R-BTA-380108); (R-BTA-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "22909117;25982572;32122602", "class_list": "", "function": "IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB., [RefSeq, PubMed]; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The chemokines CCL2 and CXCL10 produced by bovine endometrial epithelial cells induce migration of bovine B lymphocytes, contributing to transuterine transmission of BLV infection., [RefSeq, PubMed]; These results demonstrated that bovine colonic cells seem capable to respond to E. bovis merozoite I infection by the upregulation of CXCL10 and GM-CSF gene transcription., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding;GO:0048248 CXCR3 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2KIQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIU0-1", "uniprot_id": [ { "id": "VTI1B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIU0", "type": "external" } ], "mass": 26709.0, "length": 232, "protein_name": "Vesicle transport through interaction with t-SNAREs homolog 1B", "gene_name": "VTI1B", "organism": "Bovine", "refseq_name": "vesicle transport through interaction with t-SNAREs homolog 1B", "refseq_ac": [ { "id": "NP_001073115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073115", "type": "external" } ], "gene_names_uniprotkb": "VTI1B", "gene_names_refseq": "VTI1B", "protein_names_uniprotkb": "Vesicle transport through interaction with t-SNAREs homolog 1B", "protein_names_refseq": "vesicle transport through interaction with t-SNAREs homolog 1B", "tax_id": 9913, "disease": "", "pathway": " (bta:780809)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE). On late endosomes, regulates trafficking from late endosomes to the lysosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:0042147 retrograde transport, endosome to Golgi;GO:1903076 regulation of protein localization to plasma membrane;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIU0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIV1-1", "uniprot_id": [ { "id": "S22A9_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIV1", "type": "external" } ], "mass": 61540.0, "length": 552, "protein_name": "Organic anion transporter 7", "gene_name": "SLC22A9", "organism": "Bovine", "refseq_name": "organic anion transporter 7", "refseq_ac": [ { "id": "NP_001039471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039471", "type": "external" } ], "gene_names_uniprotkb": "SLC22A9", "gene_names_refseq": "SLC22A25; SLC22A9; bOAT7", "protein_names_uniprotkb": "Organic anion transporter 7; Organic anion/short-chain fatty acid exchanger; Solute carrier family 22 member 9; bOAT7", "protein_names_refseq": "organic anion transporter 4; organic anion transporter 7; organic anion/short-chain fatty acid exchanger; solute carrier family 22 (organic anion/cation transporter), member 9; solute carrier family 22 member 9; solute carrier family 22, member 25", "tax_id": 9913, "disease": "", "pathway": " (bta:508494)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sodium-independent organic anion transporter, exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS). Can transport the statin pravastatin and may contribute to its disposition into the hepatocytes when the function of OATPs is compromised. It is specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate (propanoate), butyrate (butanoate) and valerate (pentanoate). May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs, in particular butanoate, at the sinusoidal membrane of hepatocytes., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity;GO:0015636 short-chain fatty acid transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0015711 organic anion transport;GO:0043252 sodium-independent organic anion transport;GO:0015913 short-chain fatty acid transmembrane transport;GO:0009914 hormone transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIV1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIX5-1", "uniprot_id": [ { "id": "ECSCR_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIX5", "type": "external" } ], "mass": 20639.0, "length": 197, "protein_name": "Endothelial cell-specific chemotaxis regulator", "gene_name": "ECSCR", "organism": "Bovine", "refseq_name": "endothelial cell-specific chemotaxis regulator isoform 3 precursor", "refseq_ac": [ { "id": "NP_001039564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039564", "type": "external" } ], "gene_names_uniprotkb": "ECSCR; ECSM2", "gene_names_refseq": "ECSCR; ECSM2", "protein_names_uniprotkb": "Endothelial cell-specific chemotaxis regulator; Endothelial cell-specific molecule 2", "protein_names_refseq": "endothelial cell-specific chemotaxis regulator isoform 3 precursor; endothelial cell-specific chemotaxis regulator; endothelial cell-specific molecule 2", "tax_id": 9913, "disease": "", "pathway": " (bta:511765)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006935 chemotaxis;GO:0030154 cell differentiation;GO:0006915 apoptotic process;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIX5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIY2-1", "uniprot_id": [ { "id": "CLD15_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIY2", "type": "external" } ], "mass": 25074.0, "length": 235, "protein_name": "Claudin-15", "gene_name": "CLDN15", "organism": "Bovine", "refseq_name": "claudin-15", "refseq_ac": [ { "id": "NP_001039651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039651", "type": "external" } ], "gene_names_uniprotkb": "CLDN15", "gene_names_refseq": "CLDN15", "protein_names_uniprotkb": "Claudin-15", "protein_names_refseq": "claudin-15", "tax_id": 9913, "disease": "", "pathway": " (bta:514998)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (By similarity). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and intestinal morphogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0160187 paracellular tight junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0070160 tight junction", "go_biological_process": "GO:1904729 regulation of intestinal lipid absorption;GO:0006811 monoatomic ion transport;GO:0160184 paracellular transport;GO:1903985 regulation of intestinal D-glucose absorption", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIY2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIZ8-1", "uniprot_id": [ { "id": "MCM6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIZ8", "type": "external" } ], "mass": 92930.0, "length": 821, "protein_name": "DNA replication licensing factor MCM6", "gene_name": "MCM6", "organism": "Bovine", "refseq_name": "DNA replication licensing factor MCM6", "refseq_ac": [ { "id": "NP_001039699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039699", "type": "external" } ], "gene_names_uniprotkb": "MCM6", "gene_names_refseq": "MCM6", "protein_names_uniprotkb": "DNA replication licensing factor MCM6; 3.6.4.12", "protein_names_refseq": "DNA replication licensing factor MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe); minichromosome maintenance deficient 6 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:517812)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006270 DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication;GO:1902969 mitotic DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIZ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ14-1", "uniprot_id": [ { "id": "PAF1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ14", "type": "external" } ], "mass": 60280.0, "length": 532, "protein_name": "RNA polymerase II-associated factor 1 homolog", "gene_name": "PAF1", "organism": "Bovine", "refseq_name": "RNA polymerase II-associated factor 1 homolog", "refseq_ac": [ { "id": "NP_001039758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039758", "type": "external" } ], "gene_names_uniprotkb": "PAF1", "gene_names_refseq": "PAF1", "protein_names_uniprotkb": "RNA polymerase II-associated factor 1 homolog", "protein_names_refseq": "Paf1, RNA polymerase II associated factor, homolog; RNA polymerase II-associated factor 1 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:528744); (R-BTA-674695); (R-BTA-75955); (R-BTA-8866654); (R-BTA-9943411)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0001650 fibrillar center;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071222 cellular response to lipopolysaccharide;GO:0016055 Wnt signaling pathway;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJ14-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ36-1", "uniprot_id": [ { "id": "DUS6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ36", "type": "external" } ], "mass": 42307.0, "length": 381, "protein_name": "Dual specificity protein phosphatase 6", "gene_name": "DUSP6", "organism": "Bovine", "refseq_name": "dual specificity protein phosphatase 6", "refseq_ac": [ { "id": "NP_001039660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039660", "type": "external" } ], "gene_names_uniprotkb": "DUSP6", "gene_names_refseq": "DUSP6", "protein_names_uniprotkb": "Dual specificity protein phosphatase 6; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 6", "tax_id": 9913, "disease": "", "pathway": " (bta:515310); (R-BTA-112409); (R-BTA-202670); (R-BTA-5675221)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "16305752;36474130", "class_list": "", "function": "Abundance of Dual Specificity Phosphatase (DUSP) 1 and DUSP6 mRNA Is Regulated by Hippo Signaling in Bovine Pre-ovulatory Granulosa Cells., [RefSeq, PubMed]; Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity;GO:0033550 MAP kinase tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060420 regulation of heart growth;GO:0043065 positive regulation of apoptotic process;GO:0051409 response to nitrosative stress;GO:0070373 negative regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2KJ36-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ56-1", "uniprot_id": [ { "id": "HOME1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ56", "type": "external" } ], "mass": 40370.0, "length": 354, "protein_name": "Homer protein homolog 1", "gene_name": "HOMER1", "organism": "Bovine", "refseq_name": "homer protein homolog 1", "refseq_ac": [ { "id": "NP_001069520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069520", "type": "external" } ], "gene_names_uniprotkb": "HOMER1", "gene_names_refseq": "HOMER1", "protein_names_uniprotkb": "Homer protein homolog 1; Homer-1", "protein_names_refseq": "homer 1; homer homolog 1; homer protein homolog 1; homer scaffolding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:535311); (R-BTA-6794361)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035256 G protein-coupled glutamate receptor binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0051262 protein tetramerization;GO:1902950 regulation of dendritic spine maintenance;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:2001256 regulation of store-operated calcium entry;GO:0007216 G protein-coupled glutamate receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJ56-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ63-1", "uniprot_id": [ { "id": "KLKB1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ63", "type": "external" } ], "mass": 70994.0, "length": 636, "protein_name": "Plasma kallikrein", "gene_name": "KLKB1", "organism": "Bovine", "refseq_name": "plasma kallikrein precursor", "refseq_ac": [ { "id": "NP_001039817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039817", "type": "external" } ], "gene_names_uniprotkb": "KLKB1", "gene_names_refseq": "KLKB1", "protein_names_uniprotkb": "Plasma kallikrein; 3.4.21.34; Fletcher factor; Kininogenin; Plasma prekallikrein", "protein_names_refseq": "fletcher factor; kallikrein B, plasma (Fletcher factor) 1; kininogenin; plasma kallikrein precursor; plasma kallikrein; plasma prekallikrein", "tax_id": 9913, "disease": "", "pathway": " (bta:533547); (R-BTA-1592389); (R-BTA-9855719); (R-BTA-9935598); (R-BTA-9970672)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin (By similarity)., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.4.21.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.7", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.21.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.38", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.21.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.22", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042803 protein homodimerization activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0007596 blood coagulation;GO:0042730 fibrinolysis;GO:0031639 plasminogen activation;GO:0051919 positive regulation of fibrinolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJ63-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ72-1", "uniprot_id": [ { "id": "UBP21_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ72", "type": "external" } ], "mass": 62619.0, "length": 565, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 21", "gene_name": "USP21", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 21", "refseq_ac": [ { "id": "NP_001039841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039841", "type": "external" } ], "gene_names_uniprotkb": "USP21", "gene_names_refseq": "USP21", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 21; 3.4.19.12; Deubiquitinating enzyme 21; Ubiquitin thioesterase 21; Ubiquitin-specific-processing protease 21", "protein_names_refseq": "deubiquitinating enzyme 21; ubiquitin carboxyl-terminal hydrolase 21; ubiquitin thioesterase 21; ubiquitin thiolesterase 21; ubiquitin-specific-processing protease 21", "tax_id": 9913, "disease": "", "pathway": " (bta:534273)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019784 deNEDDylase activity;GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding;GO:0008234 cysteine-type peptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJ72-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ83-1", "uniprot_id": [ { "id": "CBPN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ83", "type": "external" } ], "mass": 52669.0, "length": 462, "protein_name": "Carboxypeptidase N catalytic chain", "gene_name": "CPN1", "organism": "Bovine", "refseq_name": "carboxypeptidase N catalytic chain precursor", "refseq_ac": [ { "id": "NP_001069548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069548", "type": "external" } ], "gene_names_uniprotkb": "CPN1", "gene_names_refseq": "CPN1", "protein_names_uniprotkb": "Carboxypeptidase N catalytic chain; 3.4.17.3; CPN; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit", "protein_names_refseq": "CPN; carboxypeptidase N catalytic chain precursor; carboxypeptidase N catalytic chain; carboxypeptidase N small subunit; carboxypeptidase N, polypeptide 1", "tax_id": 9913, "disease": "", "pathway": " (bta:536753)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016485 protein processing;GO:0006518 peptide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJ83-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ98-1", "uniprot_id": [ { "id": "TTYH1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ98", "type": "external" } ], "mass": 49230.0, "length": 450, "protein_name": "Protein tweety homolog 1", "gene_name": "TTYH1", "organism": "Bovine", "refseq_name": "protein tweety homolog 1", "refseq_ac": [ { "id": "NP_001070483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070483", "type": "external" } ], "gene_names_uniprotkb": "TTYH1", "gene_names_refseq": "TTYH1", "protein_names_uniprotkb": "Protein tweety homolog 1; Volume-regulated anion channel subunit TTYH1", "protein_names_refseq": "protein tweety homolog 1; tweety homolog 1; volume-regulated anion channel subunit TTYH1", "tax_id": 9913, "disease": "", "pathway": " (bta:767943)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0072320 volume-sensitive chloride channel activity;GO:0005229 intracellularly calcium-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030868 smooth endoplasmic reticulum membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0015813 L-glutamate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJ98-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJC6-1", "uniprot_id": [ { "id": "METK1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJC6", "type": "external" } ], "mass": 43761.0, "length": 396, "protein_name": "S-adenosylmethionine synthase isoform type-1", "gene_name": "MAT1A", "organism": "Bovine", "refseq_name": "S-adenosylmethionine synthase isoform type-1", "refseq_ac": [ { "id": "NP_001039962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039962", "type": "external" } ], "gene_names_uniprotkb": "MAT1A", "gene_names_refseq": "MAT1A", "protein_names_uniprotkb": "S-adenosylmethionine synthase isoform type-1; 2.5.1.6; AdoMet synthase 1; MAT 1; Methionine adenosyltransferase 1", "protein_names_refseq": "MAT 1; S-adenosylmethionine synthase isoform type-1; adoMet synthase 1; adoMet synthetase 1; methionine adenosyltransferase 1; methionine adenosyltransferase I, alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:541078)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004478 methionine adenosyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0006556 S-adenosylmethionine biosynthetic process;GO:0009087 L-methionine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJC6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJD0-1", "uniprot_id": [ { "id": "TBB5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJD0", "type": "external" } ], "mass": 49671.0, "length": 444, "protein_name": "Tubulin beta-5 chain", "gene_name": "TUBB5", "organism": "Bovine", "refseq_name": "tubulin beta-5 chain", "refseq_ac": [ { "id": "NP_001040014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040014", "type": "external" } ], "gene_names_uniprotkb": "TUBB5", "gene_names_refseq": "TUBB5; TUBB", "protein_names_uniprotkb": "Tubulin beta-5 chain", "protein_names_refseq": "tubulin beta-2B chain; tubulin beta-5 chain; tubulin, beta 2A; tubulin, beta polypeptide", "tax_id": 9913, "disease": "", "pathway": " (bta:615087); (R-BTA-2565942); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-6798695); (R-BTA-8854518)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "16305752;18621829;2207090;41018975;6504138;7704569", "class_list": "", "function": "The axial elastic modulus of tubulin diminishes as the length of the monomer increases., [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:2207090, PubMed:6504138, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:2207090, PubMed:6504138, PubMed:7704569)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D9A3", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0045171 intercellular bridge", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0050807 regulation of synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q2KJD0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJD2-1", "uniprot_id": [ { "id": "VAMP3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJD2", "type": "external" } ], "mass": 11535.0, "length": 104, "protein_name": "Vesicle-associated membrane protein 3", "gene_name": "VAMP3", "organism": "Bovine", "refseq_name": "vesicle-associated membrane protein 3", "refseq_ac": [ { "id": "NP_001039380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039380", "type": "external" } ], "gene_names_uniprotkb": "VAMP3; SYB3", "gene_names_refseq": "VAMP3", "protein_names_uniprotkb": "Vesicle-associated membrane protein 3; Synaptobrevin-3; VAMP-3", "protein_names_refseq": "VAMP-3; synaptobrevin-3; vesicle-associated membrane protein 3 (cellubrevin); vesicle-associated membrane protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:505379)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0034446 substrate adhesion-dependent cell spreading;GO:0016192 vesicle-mediated transport;GO:0001921 positive regulation of receptor recycling;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJD2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJD6-1", "uniprot_id": [ { "id": "ENTR1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJD6", "type": "external" } ], "mass": 39871.0, "length": 359, "protein_name": "Endosome-associated-trafficking regulator 1", "gene_name": "ENTR1", "organism": "Bovine", "refseq_name": "endosome-associated-trafficking regulator 1", "refseq_ac": [ { "id": "NP_001039605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039605", "type": "external" } ], "gene_names_uniprotkb": "ENTR1; SDCCAG3", "gene_names_refseq": "ENTR1; SDCCAG3", "protein_names_uniprotkb": "Endosome-associated-trafficking regulator 1; Serologically defined colon cancer antigen 3 homolog", "protein_names_refseq": "endosome-associated-trafficking regulator 1; serologically defined colon cancer antigen 3 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:513180)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis. Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1. Plays a role in the formation of cilia. Involved in cargo protein localization, such as PKD2, at primary cilia (By similarity). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005813 centrosome;GO:0055037 recycling endosome;GO:0030496 midbody;GO:0036064 ciliary basal body", "go_biological_process": "GO:0015031 protein transport;GO:0051301 cell division;GO:0030030 cell projection organization;GO:1903566 positive regulation of protein localization to cilium;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJD6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJI2-1", "uniprot_id": [ { "id": "STT3A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJI2", "type": "external" } ], "mass": 80656.0, "length": 705, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "gene_name": "STT3A", "organism": "Bovine", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "refseq_ac": [ { "id": "NP_001039445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039445", "type": "external" } ], "gene_names_uniprotkb": "STT3A", "gene_names_refseq": "STT3A", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; 2.4.99.18; Oligosaccharyl transferase subunit STT3A; STT3-A", "protein_names_refseq": "STT3, subunit of the oligosaccharyltransferase complex, homolog A; STT3-A; STT3A, catalytic subunit of the oligosaccharyltransferase complex; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; integral membrane protein 1; oligosaccharyl transferase subunit STT3A", "tax_id": 9913, "disease": "", "pathway": " (bta:507815); (R-BTA-9768727); (R-BTA-9931295)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A. STT3A-containing OST-A complex is also required to prevent hyperglycosylation of some target proteins by preventing glycosylation of facultative sites before folding of target proteins is completed., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity", "go_cellular_component": "GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJI2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2M2T5-1", "uniprot_id": [ { "id": "COMD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2M2T5", "type": "external" } ], "mass": 20983.0, "length": 188, "protein_name": "COMM domain-containing protein 1", "gene_name": "COMMD1", "organism": "Bovine", "refseq_name": "COMM domain-containing protein 1", "refseq_ac": [ { "id": "NP_001039849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039849", "type": "external" } ], "gene_names_uniprotkb": "COMMD1", "gene_names_refseq": "COMMD1", "protein_names_uniprotkb": "COMM domain-containing protein 1", "protein_names_refseq": "COMM domain-containing protein 1; copper metabolism (Murr1) domain containing 1", "tax_id": 9913, "disease": "", "pathway": " (bta:534683)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (By similarity). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (By similarity). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (By similarity). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (By similarity). Promotes CFTR cell surface expression through regulation of its ubiquitination (By similarity). Down-regulates SOD1 activity by interfering with its homodimerization (By similarity). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (By similarity). Can bind one copper ion per monomer (By similarity). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (By similarity). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (By similarity). Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0055037 recycling endosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0015031 protein transport;GO:0031398 positive regulation of protein ubiquitination;GO:2000009 negative regulation of protein localization to cell surface;GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2M2T5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2NKY8-1", "uniprot_id": [ { "id": "DHX30_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2NKY8", "type": "external" } ], "mass": 135946.0, "length": 1220, "protein_name": "ATP-dependent RNA helicase DHX30", "gene_name": "DHX30", "organism": "Bovine", "refseq_name": "ATP-dependent RNA helicase DHX30", "refseq_ac": [ { "id": "NP_001070003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070003", "type": "external" } ], "gene_names_uniprotkb": "DHX30", "gene_names_refseq": "DHX30", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX30; 3.6.4.13; DEAH box protein 30", "protein_names_refseq": "ATP-dependent RNA helicase DHX30; DEAH (Asp-Glu-Ala-His) box helicase 30; DEAH (Asp-Glu-Ala-His) box polypeptide 30; DEAH box protein 30; DEAH-box helicase 30; putative ATP-dependent RNA helicase DHX30", "tax_id": 9913, "disease": "", "pathway": " (bta:767607)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA dependent helicase. Plays an important role in the assembly of the mitochondrial large ribosomal subunit. Required for optimal function of the zinc-finger antiviral protein ZC3HAV1. Associates with mitochondrial DNA. Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0002151 G-quadruplex RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0007417 central nervous system development;GO:1902775 mitochondrial large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2NKY8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2NL05-1", "uniprot_id": [ { "id": "KIF2A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2NL05", "type": "external" } ], "mass": 74994.0, "length": 660, "protein_name": "Kinesin-like protein KIF2A", "gene_name": "KIF2A", "organism": "Bovine", "refseq_name": "kinesin-like protein KIF2A", "refseq_ac": [ { "id": "NP_001070541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070541", "type": "external" } ], "gene_names_uniprotkb": "KIF2A", "gene_names_refseq": "KIF2A", "protein_names_uniprotkb": "Kinesin-like protein KIF2A", "protein_names_refseq": "kinesin heavy chain member 2A; kinesin-like protein KIF2A", "tax_id": 9913, "disease": "", "pathway": " (bta:768014)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2NL05-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2NL29-1", "uniprot_id": [ { "id": "INO1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2NL29", "type": "external" } ], "mass": 60761.0, "length": 557, "protein_name": "Inositol-3-phosphate synthase 1", "gene_name": "ISYNA1", "organism": "Bovine", "refseq_name": "inositol-3-phosphate synthase 1", "refseq_ac": [ { "id": "NP_001039497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039497", "type": "external" } ], "gene_names_uniprotkb": "ISYNA1; INO1", "gene_names_refseq": "ISYNA1", "protein_names_uniprotkb": "Inositol-3-phosphate synthase 1; 5.5.1.4; IPS 1; MI-1-P synthase; MIP synthase; Myo-inositol 1-phosphate synthase", "protein_names_refseq": "IPS 1; MI-1-P synthase; MIP synthase; inositol-3-phosphate synthase 1; myo-inositol 1-phosphate synthase A1; myo-inositol-1-phosphate synthase", "tax_id": 9913, "disease": "", "pathway": " (bta:509394); (R-BTA-1855183)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "885873", "class_list": "", "function": "Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:885873). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.5.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.5.1.4", "type": "external" } ], "go_molecular_function": "GO:0004512 inositol-3-phosphate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006021 inositol biosynthetic process;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2NL29-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9N3-1", "uniprot_id": [ { "id": "NTM1A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9N3", "type": "external" } ], "mass": 25289.0, "length": 223, "protein_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "gene_name": "NTMT1", "organism": "Bovine", "refseq_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "refseq_ac": [ { "id": "NP_001033306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033306", "type": "external" } ], "gene_names_uniprotkb": "NTMT1; METTL11A", "gene_names_refseq": "C11H9orf32; C9orf32; METTL11A; NTM1A; NTMT1", "protein_names_uniprotkb": "N-terminal Xaa-Pro-Lys N-methyltransferase 1; 2.1.1.244; Alpha N-terminal protein methyltransferase 1A; Methyltransferase-like protein 11A; NTM1A; X-Pro-Lys N-terminal protein methyltransferase 1A", "protein_names_refseq": "N-terminal Xaa-Pro-Lys N-methyltransferase 1; X-Pro-Lys N-terminal protein methyltransferase 1A; alpha N-terminal protein methyltransferase 1A; methyltransferase like 11A; methyltransferase-like protein 11A", "tax_id": 9913, "disease": "", "pathway": " (bta:617042)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.244", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.244", "type": "external" } ], "go_molecular_function": "GO:0071885 N-terminal protein N-methyltransferase activity;GO:0008276 protein methyltransferase activity;GO:0042054 histone methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0018013 N-terminal peptidyl-glycine methylation;GO:0018016 N-terminal peptidyl-proline dimethylation;GO:0035572 N-terminal peptidyl-serine dimethylation;GO:0035573 N-terminal peptidyl-serine trimethylation;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2T9N3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9P4-1", "uniprot_id": [ { "id": "NASP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9P4", "type": "external" } ], "mass": 83688.0, "length": 777, "protein_name": "Nuclear autoantigenic sperm protein", "gene_name": "NASP", "organism": "Bovine", "refseq_name": "nuclear autoantigenic sperm protein", "refseq_ac": [ { "id": "NP_001033177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033177", "type": "external" } ], "gene_names_uniprotkb": "NASP", "gene_names_refseq": "NASP", "protein_names_uniprotkb": "Nuclear autoantigenic sperm protein; NASP", "protein_names_refseq": "nuclear autoantigenic sperm protein (histone-binding); nuclear autoantigenic sperm protein", "tax_id": 9913, "disease": "", "pathway": " (bta:512427)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26690724", "class_list": "", "function": "Component of the histone chaperone network (By similarity). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (By similarity). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA., [UniProtKB, UniProtKB, UniProtKB]; NASP mRNA expression is required for preimplantation development into the blastocyst stage in cattle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0015031 protein transport;GO:0006260 DNA replication;GO:0006335 DNA replication-dependent chromatin assembly;GO:0034080 CENP-A containing chromatin assembly;GO:0001824 blastocyst development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2T9P4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9S4-1", "uniprot_id": [ { "id": "PGP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9S4", "type": "external" } ], "mass": 34320.0, "length": 321, "protein_name": "Phosphoglycolate phosphatase", "gene_name": "PGP", "organism": "Bovine", "refseq_name": "glycerol-3-phosphate phosphatase", "refseq_ac": [ { "id": "NP_001033261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033261", "type": "external" } ], "gene_names_uniprotkb": "PGP", "gene_names_refseq": "AUM; G3PP; PGP", "protein_names_uniprotkb": "Phosphoglycolate phosphatase; 3.1.3.18; 3.1.3.21; 3.1.3.48; AUM; Aspartate-based ubiquitous Mg(2+)-dependent phosphatase; G3PP; Glycerol-3-phosphate phosphatase", "protein_names_refseq": "PGPase; aspartate-based ubiquitous Mg(2+)-dependent phosphatase; glycerol-3-phosphate phosphatase", "tax_id": 9913, "disease": "", "pathway": " (bta:538173); (R-BTA-1483206)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphatase with activity against multiple substrates (By similarity). Acts as a metabolite repair enzyme which eliminates toxic glycolytic side products (By similarity). Dephosphorylates 2-phosphoglycolate which is generated during the repair of oxidative DNA lesions (By similarity). This controls triosephosphate isomerase activity, glycerolipid partitioning and cell proliferation in the embryo and is required for embryonic development (By similarity). Dephosphorylates 4-phosphoerythronate, a side product which is produced by GAPDH and which inhibits 6-phosphogluconate dehydrogenase (By similarity). Dephosphorylation of 4-phosphoerythronate prevents the accumulation of high 4-phosphoerythronate levels which would otherwise inhibit the pentose phosphate pathway (By similarity). Dephosphorylates 2-phospho-L-lactate which is a product of a pyruvate kinase side reaction (By similarity). This prevents the inhibition of fructose-2,6-bisphosphate production and allows glycolysis to occur (By similarity). Has glycerol-3-phosphate phosphatase activity, hydrolyzing glycerol-3-phosphate into glycerol and thereby regulating the cellular levels of glycerol-3-phosphate, a metabolic intermediate of glucose, lipid and energy metabolism (By similarity). Has been shown to have tyrosine-protein phosphatase activity although the physiological relevance is unclear (By similarity). In vitro, has phosphatase activity toward ADP, ATP, GDP and GTP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0008967 phosphoglycolate phosphatase activity;GO:0000121 sn-glycerol 1-phosphatase activity;GO:0043136 sn-glycerol 3-phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0006114 glycerol biosynthetic process;GO:0045721 negative regulation of gluconeogenesis;GO:0110052 toxic metabolite repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2T9S4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9U2-1", "uniprot_id": [ { "id": "ODFP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9U2", "type": "external" } ], "mass": 75498.0, "length": 657, "protein_name": "Outer dense fiber protein 2", "gene_name": "ODF2", "organism": "Bovine", "refseq_name": "outer dense fiber protein 2", "refseq_ac": [ { "id": "NP_001033269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033269", "type": "external" } ], "gene_names_uniprotkb": "ODF2", "gene_names_refseq": "ODF2", "protein_names_uniprotkb": "Outer dense fiber protein 2; Cenexin; Outer dense fiber of sperm tails protein 2", "protein_names_refseq": "cenexin; outer dense fiber of sperm tails protein 2; outer dense fiber protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:539043)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005874 microtubule;GO:0036126 sperm flagellum;GO:0005814 centriole", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:1902017 regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2T9U2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9X7-1", "uniprot_id": [ { "id": "UB2E3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9X7", "type": "external" } ], "mass": 22913.0, "length": 207, "protein_name": "Ubiquitin-conjugating enzyme E2 E3", "gene_name": "UBE2E3", "organism": "Bovine", "refseq_name": "ubiquitin-conjugating enzyme E2 E3", "refseq_ac": [ { "id": "NP_001073251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073251", "type": "external" } ], "gene_names_uniprotkb": "UBE2E3", "gene_names_refseq": "UBE2E3", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 E3; 2.3.2.23; E2 ubiquitin-conjugating enzyme E3; Ubiquitin carrier protein E3; Ubiquitin-protein ligase E3", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme E3; ubiquitin carrier protein E3; ubiquitin-conjugating enzyme E2 E3; ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast); ubiquitin-protein ligase E3", "tax_id": 9913, "disease": "", "pathway": " (bta:534349); (R-BTA-8866652); (R-BTA-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070979 protein K11-linked ubiquitination;GO:0070936 protein K48-linked ubiquitination;GO:0070534 protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2T9X7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9Z0-1", "uniprot_id": [ { "id": "TRI17_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9Z0", "type": "external" } ], "mass": 54888.0, "length": 475, "protein_name": "E3 ubiquitin-protein ligase TRIM17", "gene_name": "TRIM17", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase TRIM17", "refseq_ac": [ { "id": "NP_001098481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098481", "type": "external" } ], "gene_names_uniprotkb": "TRIM17", "gene_names_refseq": "TRIM17", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM17; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM17; Tripartite motif-containing protein 17", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM17; RING-type E3 ubiquitin transferase TRIM17; tripartite motif-containing protein 17", "tax_id": 9913, "disease": "", "pathway": " (bta:618634)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation. Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation. Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (By similarity). Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death. In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities. Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (By similarity). Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0044790 suppression of viral release by host;GO:0045087 innate immune response;GO:0046598 positive regulation of viral entry into host cell;GO:0016567 protein ubiquitination;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2T9Z0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA03-1", "uniprot_id": [ { "id": "UB2J2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TA03", "type": "external" } ], "mass": 28848.0, "length": 259, "protein_name": "Ubiquitin-conjugating enzyme E2 J2", "gene_name": "UBE2J2", "organism": "Bovine", "refseq_name": "ubiquitin-conjugating enzyme E2 J2", "refseq_ac": [ { "id": "NP_001033132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033132", "type": "external" } ], "gene_names_uniprotkb": "UBE2J2", "gene_names_refseq": "UBE2J2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 J2; 2.3.2.23; E2 ubiquitin-conjugating enzyme J2", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme J2; ubiquitin-conjugating enzyme E2 J2; ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)", "tax_id": 9913, "disease": "", "pathway": " (bta:506103); (R-BTA-9609523); (R-BTA-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0036503 ERAD pathway;GO:0006986 response to unfolded protein;GO:0085020 protein K6-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TA03-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA10-1", "uniprot_id": [ { "id": "UB2D1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TA10", "type": "external" } ], "mass": 16602.0, "length": 147, "protein_name": "Ubiquitin-conjugating enzyme E2 D1", "gene_name": "UBE2D1", "organism": "Bovine", "refseq_name": "ubiquitin-conjugating enzyme E2 D1", "refseq_ac": [ { "id": "NP_001033256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033256", "type": "external" } ], "gene_names_uniprotkb": "UBE2D1", "gene_names_refseq": "UBE2D1", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 D1; (E3-independent) E2 ubiquitin-conjugating enzyme D1; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme D1; Ubiquitin carrier protein D1; Ubiquitin-protein ligase D1", "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme D1; E2 ubiquitin-conjugating enzyme D1; ubiquitin carrier protein D1; ubiquitin-conjugating enzyme E2 D1; ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); ubiquitin-protein ligase D1", "tax_id": 9913, "disease": "", "pathway": " (bta:535287); (R-BTA-1234176); (R-BTA-141430); (R-BTA-174048); (R-BTA-174084); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-176407); (R-BTA-176408); (R-BTA-176409); (R-BTA-176412); (R-BTA-179409); (R-BTA-201451); (R-BTA-2173795); (R-BTA-2467813); (R-BTA-2559582); (R-BTA-5357905); (R-BTA-5689896); (R-BTA-68867); (R-BTA-69017); (R-BTA-8866652); (R-BTA-8866654); (R-BTA-8951664); (R-BTA-9033241); (R-BTA-937041); (R-BTA-9705462); (R-BTA-983168); (R-BTA-9954709); (R-BTA-9954716)", "pathway_count": 30, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TA10-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA14-1", "uniprot_id": [ { "id": "PCP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TA14", "type": "external" } ], "mass": 56671.0, "length": 499, "protein_name": "Lysosomal Pro-X carboxypeptidase", "gene_name": "PRCP", "organism": "Bovine", "refseq_name": "lysosomal Pro-X carboxypeptidase precursor", "refseq_ac": [ { "id": "NP_001033253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033253", "type": "external" } ], "gene_names_uniprotkb": "PRCP", "gene_names_refseq": "PRCP", "protein_names_uniprotkb": "Lysosomal Pro-X carboxypeptidase; 3.4.16.2; PRCP; Proline carboxypeptidase; Prolylcarboxypeptidase", "protein_names_refseq": "lysosomal Pro-X carboxypeptidase precursor; lysosomal Pro-X carboxypeptidase; proline carboxypeptidase; prolylcarboxypeptidase (angiotensinase C)", "tax_id": 9913, "disease": "", "pathway": " (bta:534927)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0004185 serine-type carboxypeptidase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0043535 regulation of blood vessel endothelial cell migration;GO:0003085 negative regulation of systemic arterial blood pressure;GO:0060055 angiogenesis involved in wound healing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TA14-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA32-1", "uniprot_id": [ { "id": "TYSY_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TA32", "type": "external" } ], "mass": 39785.0, "length": 354, "protein_name": "Thymidylate synthase", "gene_name": "TYMS", "organism": "Bovine", "refseq_name": "thymidylate synthase", "refseq_ac": [ { "id": "NP_001032905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032905", "type": "external" } ], "gene_names_uniprotkb": "TYMS; TS", "gene_names_refseq": "TS; TYMS", "protein_names_uniprotkb": "Thymidylate synthase; 2.1.1.45; TSase; TS", "protein_names_refseq": "TSase; thymidylate synthase", "tax_id": 9913, "disease": "", "pathway": " (bta:507631)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11130975", "class_list": "", "function": "Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the mitochondrial and nuclear de novo thymidylate biosynthesis pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9N1D3", "ec_number_list": [ { "id": "2.1.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.45", "type": "external" } ], "go_molecular_function": "GO:0004799 thymidylate synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006231 dTMP biosynthetic process;GO:0032259 methylation;GO:0006235 dTTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2TA32-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBH7-1", "uniprot_id": [ { "id": "RAB4A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBH7", "type": "external" } ], "mass": 24393.0, "length": 218, "protein_name": "Ras-related protein Rab-4A", "gene_name": "RAB4A", "organism": "Bovine", "refseq_name": "ras-related protein Rab-4A", "refseq_ac": [ { "id": "NP_001033774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033774", "type": "external" } ], "gene_names_uniprotkb": "RAB4A", "gene_names_refseq": "RAB4A; RAB4", "protein_names_uniprotkb": "Ras-related protein Rab-4A; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-4A", "tax_id": 9913, "disease": "", "pathway": " (bta:615849); (R-BTA-1660499); (R-BTA-8854214); (R-BTA-8873719); (R-BTA-8875656)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "15331762;33709423", "class_list": "", "function": "A conserved haplotype in Wagyu cattle contains RAB4A whose encoded protein regulates glucose trafficking in muscle and fat cells., [RefSeq, PubMed]; Receptor recycling is mediated by AP-1/clathrin-coated vesicles and regulated by rab4 and rabaptin-5/rabex-5., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB4A is involved in protein transport. Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0055037 recycling endosome;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane;GO:0032593 insulin-responsive compartment;GO:0005886 plasma membrane", "go_biological_process": "GO:0015031 protein transport;GO:0030100 regulation of endocytosis;GO:0016192 vesicle-mediated transport;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2TBH7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBI2-1", "uniprot_id": [ { "id": "THAP4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBI2", "type": "external" } ], "mass": 63450.0, "length": 584, "protein_name": "Peroxynitrite isomerase THAP4", "gene_name": "THAP4", "organism": "Bovine", "refseq_name": "peroxynitrite isomerase THAP4", "refseq_ac": [ { "id": "NP_001033758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033758", "type": "external" } ], "gene_names_uniprotkb": "THAP4", "gene_names_refseq": "Nb(III); THAP4", "protein_names_uniprotkb": "Peroxynitrite isomerase THAP4; 5.99.-.-; Ferric nitrobindin; Nb(III); THAP domain-containing protein 4", "protein_names_refseq": "THAP domain-containing protein 4; ferric nitrobindin; peroxynitrite isomerase THAP4", "tax_id": 9913, "disease": "", "pathway": " (bta:507503)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.99.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.99.-.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0070026 nitric oxide binding;GO:0062213 peroxynitrite isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042126 nitrate metabolic process;GO:0006570 tyrosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBI2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBK5-1", "uniprot_id": [ { "id": "TMED1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBK5", "type": "external" } ], "mass": 25138.0, "length": 227, "protein_name": "Transmembrane emp24 domain-containing protein 1", "gene_name": "TMED1", "organism": "Bovine", "refseq_name": "transmembrane emp24 domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_001033652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033652", "type": "external" } ], "gene_names_uniprotkb": "TMED1", "gene_names_refseq": "TMED1", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 1; p24 family protein gamma-1; p24gamma1", "protein_names_refseq": "p24 family protein gamma-1; p24gamma1; transmembrane emp24 domain-containing protein 1 precursor; transmembrane emp24 domain-containing protein 1; transmembrane emp24 protein transport domain containing 1", "tax_id": 9913, "disease": "", "pathway": " (bta:538144)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1. Plays also a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBK5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBL8-1", "uniprot_id": [ { "id": "CDK10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBL8", "type": "external" } ], "mass": 41047.0, "length": 361, "protein_name": "Cyclin-dependent kinase 10", "gene_name": "CDK10", "organism": "Bovine", "refseq_name": "cyclin-dependent kinase 10", "refseq_ac": [ { "id": "NP_001033666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033666", "type": "external" } ], "gene_names_uniprotkb": "CDK10", "gene_names_refseq": "CDK10", "protein_names_uniprotkb": "Cyclin-dependent kinase 10; 2.7.11.22; Cell division protein kinase 10", "protein_names_refseq": "cell division protein kinase 10; cyclin-dependent kinase (CDC2-like) 10; cyclin-dependent kinase 10", "tax_id": 9913, "disease": "", "pathway": " (bta:615171)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0036064 ciliary basal body", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0032956 regulation of actin cytoskeleton organization;GO:0000086 G2/M transition of mitotic cell cycle;GO:0007346 regulation of mitotic cell cycle;GO:0018107 peptidyl-threonine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBL8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBM7-1", "uniprot_id": [ { "id": "MMP23_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBM7", "type": "external" } ], "mass": 43964.0, "length": 393, "protein_name": "Matrix metalloproteinase-23", "gene_name": "MMP23", "organism": "Bovine", "refseq_name": "matrix metalloproteinase-23", "refseq_ac": [ { "id": "NP_001033645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033645", "type": "external" } ], "gene_names_uniprotkb": "MMP23; MMP23B", "gene_names_refseq": "MMP23B; MMP23", "protein_names_uniprotkb": "Matrix metalloproteinase-23; 3.4.24.-; MMP-23; Matrix metallopeptidase 23B", "protein_names_refseq": "MMP-23; matrix metallopeptidase 23B; matrix metalloproteinase 23B; matrix metalloproteinase-23", "tax_id": 9913, "disease": "", "pathway": " (bta:527590)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBM7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBN1-1", "uniprot_id": [ { "id": "SMRD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBN1", "type": "external" } ], "mass": 58252.0, "length": 515, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "gene_name": "SMARCD1", "organism": "Bovine", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "refseq_ac": [ { "id": "NP_001033648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033648", "type": "external" } ], "gene_names_uniprotkb": "SMARCD1; BAF60A", "gene_names_refseq": "SMARCD1", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; 60 kDa BRG-1/Brm-associated factor subunit A; BAF60A; BRG1-associated factor 60A; SWI/SNF complex 60 kDa subunit", "protein_names_refseq": "60 kDa BRG-1/Brm-associated factor subunit A; BAF60A; BRG1-associated factor 60A; SWI/SNF complex 60 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:533232)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (By similarity). Interacts with AKIRIN2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex;GO:0071565 nBAF complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBN1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBN6-1", "uniprot_id": [ { "id": "PCID2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBN6", "type": "external" } ], "mass": 46814.0, "length": 408, "protein_name": "PCI domain-containing protein 2", "gene_name": "PCID2", "organism": "Bovine", "refseq_name": "PCI domain-containing protein 2", "refseq_ac": [ { "id": "NP_001033674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033674", "type": "external" } ], "gene_names_uniprotkb": "PCID2", "gene_names_refseq": "PCID2", "protein_names_uniprotkb": "PCI domain-containing protein 2; CSN12-like protein", "protein_names_refseq": "CSN12-like protein; PCI domain-containing protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:617943)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (By similarity). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070390 transcription export complex 2", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0015031 protein transport;GO:0048536 spleen development;GO:0006368 transcription elongation by RNA polymerase II;GO:0045814 negative regulation of gene expression, epigenetic", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBN6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MS29-1", "uniprot_id": [ { "id": "F1MS29_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MS29", "type": "external" } ], "mass": 123828.0, "length": 1096, "protein_name": "Focal adhesion kinase 1", "gene_name": "PTK2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTK2", "gene_names_refseq": "", "protein_names_uniprotkb": "Focal adhesion kinase 1; 2.7.10.2; Focal adhesion kinase-related nonkinase; Protein-tyrosine kinase 2; p125FAK; pp125FAK", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0005938 cell cortex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0007172 signal complex assembly;GO:0051239 regulation of multicellular organismal process;GO:0030154 cell differentiation;GO:0045595 regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MS29-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWZ3-1", "uniprot_id": [ { "id": "STX4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SWZ3", "type": "external" } ], "mass": 34400.0, "length": 297, "protein_name": "Syntaxin-4", "gene_name": "STX4", "organism": "Bovine", "refseq_name": "syntaxin-4", "refseq_ac": [ { "id": "NP_001030236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030236", "type": "external" } ], "gene_names_uniprotkb": "STX4", "gene_names_refseq": "STX4", "protein_names_uniprotkb": "Syntaxin-4", "protein_names_refseq": "syntaxin-4", "tax_id": 9913, "disease": "", "pathway": " (bta:508675); (R-BTA-114516); (R-BTA-199992); (R-BTA-449836)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity). Required for normal hearing (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. Required for normal hearing., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity;GO:0016230 sphingomyelin phosphodiesterase activator activity", "go_cellular_component": "GO:0032589 neuron projection membrane;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system;GO:0005901 caveola", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007605 sensory perception of sound;GO:0006887 exocytosis;GO:0034394 protein localization to cell surface;GO:0006906 vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWZ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MFK1-1", "uniprot_id": [ { "id": "F1MFK1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MFK1", "type": "external" } ], "mass": 110541.0, "length": 972, "protein_name": "Serine/threonine-protein kinase N2", "gene_name": "PKN2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PKN2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase N2; 2.7.11.13; PKN gamma; Protein kinase C-like 2; Protein-kinase C-related kinase 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5625740); (R-BTA-8980692); (R-BTA-9013106); (R-BTA-9856530)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042826 histone deacetylase binding;GO:0031267 small GTPase binding;GO:0070063 RNA polymerase binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0030027 lamellipodium;GO:0048471 perinuclear region of cytoplasm;GO:0032154 cleavage furrow;GO:0030496 midbody", "go_biological_process": "GO:0043297 apical junction assembly;GO:0010631 epithelial cell migration;GO:0006351 DNA-templated transcription;GO:0007155 cell adhesion;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MFK1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MFH7-1", "uniprot_id": [ { "id": "F1MFH7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MFH7", "type": "external" } ], "mass": 109187.0, "length": 983, "protein_name": "Ephrin type-A receptor 1", "gene_name": "EPHA1", "organism": "Bovine", "refseq_name": "ephrin type-A receptor 1 isoform X3", "refseq_ac": [ { "id": "XP_005205917", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205917", "type": "external" } ], "gene_names_uniprotkb": "EPHA1", "gene_names_refseq": "EPHA1", "protein_names_uniprotkb": "Ephrin type-A receptor 1; 2.7.10.1", "protein_names_refseq": "ephrin type-A receptor 1 isoform X3", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2682334); (R-BTA-3928663); (R-BTA-3928665)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0001968 fibronectin binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0030335 positive regulation of cell migration;GO:0030336 negative regulation of cell migration;GO:0045766 positive regulation of angiogenesis;GO:0051496 positive regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MFH7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LP2-1", "uniprot_id": [ { "id": "RADI_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LP2", "type": "external" } ], "mass": 68568.0, "length": 583, "protein_name": "Radixin", "gene_name": "RDX", "organism": "Bovine", "refseq_name": "radixin", "refseq_ac": [ { "id": "NP_001069217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069217", "type": "external" } ], "gene_names_uniprotkb": "RDX", "gene_names_refseq": "RDX", "protein_names_uniprotkb": "Radixin", "protein_names_refseq": "moesin B; radixin", "tax_id": 9913, "disease": "", "pathway": " (bta:517111)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29167409", "class_list": "", "function": "Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane., [UniProtKB]; Study defines a novel role for the sphingosine kinase-S1P-ERM pathways in phosphate-induced vascular smooth muscle cells matrix mineralization and shows that blocking these pathways with pharmacological inhibitors reduces mineralization; these results may inform new therapeutic approaches to inhibit or delay vascular calcification, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0050839 cell adhesion molecule binding;GO:0019904 protein domain specific binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045177 apical part of cell;GO:0030175 filopodium", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:1902115 regulation of organelle assembly;GO:0008360 regulation of cell shape;GO:0051693 actin filament capping;GO:2000643 positive regulation of early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32LP2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MNW2-1", "uniprot_id": [ { "id": "F1MNW2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MNW2", "type": "external" } ], "mass": 93988.0, "length": 838, "protein_name": "Fibroblast growth factor receptor", "gene_name": "FGFR2", "organism": "Bovine", "refseq_name": "fibroblast growth factor receptor 2 isoform X3", "refseq_ac": [ { "id": "XP_010818391", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010818391", "type": "external" } ], "gene_names_uniprotkb": "FGFR2", "gene_names_refseq": "FGFR2; FGFR", "protein_names_uniprotkb": "Fibroblast growth factor receptor; 2.7.10.1", "protein_names_refseq": "fibroblast growth factor receptor 2 isoform X3", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-109704); (R-BTA-1257604); (R-BTA-190375); (R-BTA-190377); (R-BTA-5654221); (R-BTA-5654695); (R-BTA-5654699); (R-BTA-5654700); (R-BTA-5654727); (R-BTA-5673001); (R-BTA-6811558)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" } ], "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0009986 cell surface", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0043410 positive regulation of MAPK cascade;GO:0006915 apoptotic process;GO:0010839 negative regulation of keratinocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MNW2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWW8-1", "uniprot_id": [ { "id": "TSP4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SWW8", "type": "external" } ], "mass": 105974.0, "length": 961, "protein_name": "Thrombospondin-4", "gene_name": "THBS4", "organism": "Bovine", "refseq_name": "thrombospondin-4 precursor", "refseq_ac": [ { "id": "NP_001029900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029900", "type": "external" } ], "gene_names_uniprotkb": "THBS4", "gene_names_refseq": "THBS4; TSP-4", "protein_names_uniprotkb": "Thrombospondin-4", "protein_names_refseq": "thrombospondin-4 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:541281); (R-BTA-186797)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14562182;15474480", "class_list": "", "function": "Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Thrombospondin-4 C-terminal peptide has a role in stimulating erythroid cell proliferation, [RefSeq, PubMed]; Thrombospondin-4 widely distributed in bovine eye where it may play role in functions of basement membranes in various tissues. Abundant in trabecular and uveo-scleral pathways. May play role in regulation of aqueous outflow resistance., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, 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"uniprot_canonical_ac": "F1MR06-1", "uniprot_id": [ { "id": "F1MR06_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MR06", "type": "external" } ], "mass": 115088.0, "length": 1047, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha", "gene_name": "ATP1A3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ATP1A3", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:282598); (R-BTA-5578775); (R-BTA-936837)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0008556 P-type potassium transmembrane transporter activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:1990535 neuron projection maintenance;GO:0006883 intracellular sodium ion homeostasis;GO:0030007 intracellular potassium ion homeostasis;GO:0036376 sodium ion export across plasma membrane;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MR06-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MI60-1", "uniprot_id": [ { "id": "F1MI60_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MI60", "type": "external" } ], "mass": 149266.0, "length": 1307, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "MAP4K4", "organism": "Bovine", "refseq_name": "mitogen-activated protein kinase kinase kinase kinase 4 isoform X13", "refseq_ac": [ { "id": "XP_059747653", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747653", "type": "external" } ], "gene_names_uniprotkb": "MAP4K4", "gene_names_refseq": "MAP4K4", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase kinase 4 isoform X13", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2559580)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000165 MAPK cascade;GO:0048812 neuron projection morphogenesis;GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MI60-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MVP8-1", "uniprot_id": [ { "id": "F1MVP8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MVP8", "type": "external" } ], "mass": 63505.0, "length": 581, "protein_name": "2-hydroxyacyl-CoA lyase 1", "gene_name": "HACL1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HACL1", "gene_names_refseq": "", "protein_names_uniprotkb": "2-hydroxyacyl-CoA lyase 1; 2-hydroxyphytanoyl-CoA lyase; 4.1.2.63; Phytanoyl-CoA 2-hydroxylase 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-389599); (R-BTA-9033241)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "4.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.-", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030976 thiamine pyrophosphate binding;GO:0106359 2-hydroxyacyl-CoA lyase activity;GO:0046872 metal ion binding;GO:0016829 lyase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0046395 carboxylic acid catabolic process;GO:0001561 fatty acid alpha-oxidation;GO:0006625 protein targeting to peroxisome;GO:1903512 phytanic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MVP8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MX48-1", "uniprot_id": [ { "id": "UVSSA_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MX48", "type": "external" } ], "mass": 76862.0, "length": 685, "protein_name": "UV-stimulated scaffold protein A", "gene_name": "UVSSA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "UVSSA", "gene_names_refseq": "", "protein_names_uniprotkb": "UV-stimulated scaffold protein A", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:510550); (R-BTA-6781823); (R-BTA-6782135); (R-BTA-6782210)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Acts as a key adapter that promotes recruitment of factors involved in TC-NER. Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites. Also promotes stabilization of ERCC6/CSB by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Mediates the recruitment of the TFIIH complex and other factors that are required for nucleotide excision repair to RNA polymerase II. Also required to inactivate stalled RNA polymerase II by blocking the access of TCEA1/TFIIS, thereby preventing reactivation of RNA polymerase II. Not involved in processing oxidative damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding;GO:0140463 chromatin-protein adaptor activity;GO:0140870 RNA polymerase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0090734 site of DNA damage;GO:0005654 nucleoplasm", "go_biological_process": "GO:0009411 response to UV;GO:0016567 protein ubiquitination;GO:0006283 transcription-coupled nucleotide-excision repair;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MX48-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MT22-1", "uniprot_id": [ { "id": "LGR5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MT22", "type": "external" } ], "mass": 99415.0, "length": 907, "protein_name": "Leucine-rich repeat-containing G protein-coupled receptor 5", "gene_name": "LGR5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LGR5", "gene_names_refseq": "", "protein_names_uniprotkb": "Leucine-rich repeat-containing G protein-coupled receptor 5", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:520189); (R-BTA-4641263)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016500 protein-hormone receptor activity;GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MT22-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZM9-1", "uniprot_id": [ { "id": "NAGK_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZM9", "type": "external" } ], "mass": 37268.0, "length": 344, "protein_name": "N-acetyl-D-glucosamine kinase", "gene_name": "NAGK", "organism": "Bovine", "refseq_name": "N-acetyl-D-glucosamine kinase", "refseq_ac": [ { "id": "NP_001029486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029486", "type": "external" } ], "gene_names_uniprotkb": "NAGK", "gene_names_refseq": "NAGK", "protein_names_uniprotkb": "N-acetyl-D-glucosamine kinase; 2.7.1.-; 2.7.1.59; 2.7.1.60; GlcNAc kinase; Muramyl dipeptide kinase; N-acetyl-D-mannosamine kinase; N-acetylglucosamine kinase", "protein_names_refseq": "N-acetyl-D-glucosamine kinase; N-acetyl-D-mannosamine kinase; glcNAc kinase; muramyl dipeptide kinase", "tax_id": 9913, "disease": "", "pathway": " (bta:508132); (R-BTA-446210)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (By similarity). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.60", "type": "external" }, { "id": "2.7.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0009384 N-acylmannosamine kinase activity;GO:0005524 ATP binding;GO:0045127 N-acetylglucosamine kinase activity;GO:0160047 muramyl dipeptide kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0045087 innate immune response;GO:0042742 defense response to bacterium;GO:0019262 N-acetylneuraminate catabolic process;GO:0032495 response to muramyl dipeptide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZM9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MF21-1", "uniprot_id": [ { "id": "PARI_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MF21", "type": "external" } ], "mass": 65429.0, "length": 582, "protein_name": "PCNA-interacting partner", "gene_name": "PARPBP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PARPBP; PARI", "gene_names_refseq": "", "protein_names_uniprotkb": "PCNA-interacting partner; PARI; PARP-1 binding protein; PARP1-binding protein; PARPBP", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:615510)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0005654 nucleoplasm", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MF21-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MK05-1", "uniprot_id": [ { "id": "RN170_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MK05", "type": "external" } ], "mass": 29690.0, "length": 259, "protein_name": "E3 ubiquitin-protein ligase RNF170", "gene_name": "RNF170", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RNF170", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF170; 2.3.2.27; RING finger protein 170; RING-type E3 ubiquitin transferase RNF170", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "E3 ubiquitin-protein ligase. Plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Selectively inhibits the TLR3-triggered innate immune response by promoting the 'Lys-48'-linked polyubiquitination and degradation of TLR3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0070936 protein K48-linked ubiquitination;GO:0034140 negative regulation of toll-like receptor 3 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MK05-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXH6-1", "uniprot_id": [ { "id": "F1MXH6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXH6", "type": "external" } ], "mass": 153264.0, "length": 1366, "protein_name": "mitogen-activated protein kinase kinase kinase", "gene_name": "MAP3K5", "organism": "Bovine", "refseq_name": "mitogen-activated protein kinase kinase kinase 5", "refseq_ac": [ { "id": "NP_001137553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137553", "type": "external" } ], "gene_names_uniprotkb": "MAP3K5", "gene_names_refseq": "ASK1; MAP3K5", "protein_names_uniprotkb": "mitogen-activated protein kinase kinase kinase; 2.7.11.25", "protein_names_refseq": "apoptosis signal-regulating kinase 1; mitogen-activated protein kinase kinase kinase 5", "tax_id": 9913, "disease": "", "pathway": " (bta:537380); (R-BTA-2559580)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:1990604 IRE1-TRAF2-ASK1 complex;GO:0005829 cytosol;GO:1902911 protein kinase complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0007254 JNK cascade;GO:0045893 positive regulation of DNA-templated transcription;GO:0070301 cellular response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXH6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGC0-1", "uniprot_id": [ { "id": "F1MGC0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGC0", "type": "external" } ], "mass": 50146.0, "length": 463, "protein_name": "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "gene_name": "SUCLA2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SUCLA2", "gene_names_refseq": "", "protein_names_uniprotkb": "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; 6.2.1.5; A-SCS; ATP-specific succinyl-CoA synthetase subunit beta; SCS-betaA; Succinyl-CoA synthetase beta-A chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-71403)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as an ATP-specific itaconyl- and malyl-CoA synthetase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.9", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0004775 succinate-CoA ligase (ADP-forming) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0009361 succinate-CoA ligase complex (ADP-forming);GO:0042709 succinate-CoA ligase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006108 malate metabolic process;GO:0110052 toxic metabolite repair;GO:0006104 succinyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGC0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBU3-1", "uniprot_id": [ { "id": "GOSR1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBU3", "type": "external" } ], "mass": 28542.0, "length": 250, "protein_name": "Golgi SNAP receptor complex member 1", "gene_name": "GOSR1", "organism": "Bovine", "refseq_name": "Golgi SNAP receptor complex member 1", "refseq_ac": [ { "id": "NP_001033614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033614", "type": "external" } ], "gene_names_uniprotkb": "GOSR1", "gene_names_refseq": "GOSR1", "protein_names_uniprotkb": "Golgi SNAP receptor complex member 1; 28 kDa Golgi SNARE protein; 28 kDa cis-Golgi SNARE p28", "protein_names_refseq": "28 kDa Golgi SNARE protein; 28 kDa cis-Golgi SNARE p28; Golgi SNAP receptor complex member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:511030); (R-BTA-6807878); (R-BTA-6811438)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "17337506", "class_list": "", "function": "Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005797 Golgi medial cisterna;GO:0005801 cis-Golgi network;GO:0031201 SNARE complex", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006906 vesicle fusion;GO:0048219 inter-Golgi cisterna vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2TBU3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MIM3-1", "uniprot_id": [ { "id": "F1MIM3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MIM3", "type": "external" } ], "mass": 102552.0, "length": 917, "protein_name": "hexokinase", "gene_name": "HKDC1", "organism": "Bovine", "refseq_name": "hexokinase HKDC1 isoform X1", "refseq_ac": [ { "id": "XP_059738582", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059738582", "type": "external" } ], "gene_names_uniprotkb": "HKDC1", "gene_names_refseq": "HKDC1", "protein_names_uniprotkb": "hexokinase; 2.7.1.1", "protein_names_refseq": "hexokinase HKDC1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-70171)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0004340 glucokinase activity;GO:0005524 ATP binding;GO:0005536 D-glucose binding;GO:0004396 hexokinase activity;GO:0008865 fructokinase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0001917 photoreceptor inner segment;GO:0005739 mitochondrion", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MIM3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHF8-1", "uniprot_id": [ { "id": "LS14A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHF8", "type": "external" } ], "mass": 50636.0, "length": 463, "protein_name": "Protein LSM14 homolog A", "gene_name": "LSM14A", "organism": "Bovine", "refseq_name": "protein LSM14 homolog A", "refseq_ac": [ { "id": "NP_001029826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029826", "type": "external" } ], "gene_names_uniprotkb": "LSM14A; RAP55A", "gene_names_refseq": "LSM14A", "protein_names_uniprotkb": "Protein LSM14 homolog A; Protein FAM61A; RNA-associated protein 55A", "protein_names_refseq": "LSM14A, SCD6 homolog A; RNA-associated protein 55A; protein LSM14 homolog A", "tax_id": 9913, "disease": "", "pathway": " (bta:538838)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex;GO:0072686 mitotic spindle", "go_biological_process": "GO:0090307 mitotic spindle assembly;GO:0017148 negative regulation of translation;GO:0033962 P-body assembly;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHF8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MLZ1-1", "uniprot_id": [ { "id": "F1MLZ1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MLZ1", "type": "external" } ], "mass": 31536.0, "length": 285, "protein_name": "Plasma membrane ascorbate-dependent reductase CYBRD1", "gene_name": "CYBRD1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CYBRD1", "gene_names_refseq": "", "protein_names_uniprotkb": "Plasma membrane ascorbate-dependent reductase CYBRD1; 7.2.1.3; Cytochrome b reductase 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:534257); (R-BTA-917937)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0140575 transmembrane monodehydroascorbate reductase activity;GO:0140571 transmembrane ascorbate ferrireductase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0031526 brush border membrane;GO:0016324 apical plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0060586 multicellular organismal-level iron ion homeostasis;GO:0140576 ascorbate homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MLZ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MW04-1", "uniprot_id": [ { "id": "F1MW04_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MW04", "type": "external" } ], "mass": 19007.0, "length": 167, "protein_name": "Epithelial membrane protein 2", "gene_name": "EMP2", "organism": "Bovine", "refseq_name": "epithelial membrane protein 2 isoform X1", "refseq_ac": [ { "id": "XP_059737203", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737203", "type": "external" } ], "gene_names_uniprotkb": "EMP2", "gene_names_refseq": "EMP2", "protein_names_uniprotkb": "Epithelial membrane protein 2", "protein_names_refseq": "epithelial membrane protein 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8J8YKN9;M5FHN3", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0045121 membrane raft;GO:0048471 perinuclear region of cytoplasm;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0008284 positive regulation of cell population proliferation;GO:0003093 regulation of glomerular filtration;GO:0006915 apoptotic process;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MW04-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1ML02-1", "uniprot_id": [ { "id": "F1ML02_BOVIN", "url": "https://www.uniprot.org/uniprot/F1ML02", "type": "external" } ], "mass": 110303.0, "length": 997, "protein_name": "Ephrin type-B receptor 3", "gene_name": "EPHB3", "organism": "Bovine", "refseq_name": "ephrin type-B receptor 3 precursor", "refseq_ac": [ { "id": "NP_001179725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179725", "type": "external" } ], "gene_names_uniprotkb": "EPHB3", "gene_names_refseq": "EPHB3", "protein_names_uniprotkb": "Ephrin type-B receptor 3; 2.7.10.1", "protein_names_refseq": "ephrin type-B receptor 3 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:540907); (R-BTA-2682334); (R-BTA-3928662); (R-BTA-3928664); (R-BTA-3928665)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005003 ephrin receptor activity;GO:0008046 axon guidance receptor activity;GO:0005005 transmembrane-ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0001525 angiogenesis;GO:0016477 cell migration;GO:0022407 regulation of cell-cell adhesion;GO:0001655 urogenital system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1ML02-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRU0-1", "uniprot_id": [ { "id": "F1MRU0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRU0", "type": "external" } ], "mass": 112610.0, "length": 989, "protein_name": "Receptor-type tyrosine-protein kinase FLT3", "gene_name": "FLT3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FLT3", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor-type tyrosine-protein kinase FLT3; 2.7.10.1; FL cytokine receptor; Fms-like tyrosine kinase 3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:512700); (R-BTA-109704); (R-BTA-1257604); (R-BTA-5673001); (R-BTA-6811558); (R-BTA-9607240); (R-BTA-9706369); (R-BTA-9706374)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0019838 growth factor binding", "go_cellular_component": "GO:0016020 membrane;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0030183 B cell differentiation;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MRU0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MTN1-1", "uniprot_id": [ { "id": "F1MTN1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MTN1", "type": "external" } ], "mass": 86536.0, "length": 784, "protein_name": "Integrin beta", "gene_name": "ITGB3", "organism": "Bovine", "refseq_name": "integrin beta-3 precursor", "refseq_ac": [ { "id": "NP_001193419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193419", "type": "external" } ], "gene_names_uniprotkb": "ITGB3", "gene_names_refseq": "INTB3; ITGB3", "protein_names_uniprotkb": "Integrin beta", "protein_names_refseq": "integrin beta 3 subunit; integrin beta-3 precursor; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)", "tax_id": 9913, "disease": "", "pathway": " (bta:282642); (R-BTA-114608); (R-BTA-1566948); (R-BTA-210990); (R-BTA-2129379); (R-BTA-216083); (R-BTA-2173789); (R-BTA-3000170); (R-BTA-3000178); (R-BTA-354192); (R-BTA-354194); (R-BTA-372708); (R-BTA-4420097); (R-BTA-5674135); (R-BTA-9769733); (R-BTA-9860927)", "pathway_count": 16, "publication_count": 4, "publication_id_list": "14724272;15331710;16928957;17039534", "class_list": "", "function": "Alphavbeta3 integrin engagement in vascular endothelium regulates Ca2+-dependent K+ current, [RefSeq, PubMed]; Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen., [RefSeq, PubMed]; Identified as receptor for foot-and-mouth disease virus, [RefSeq, PubMed]; The presence of these integrin subunits on the bovine oocyte vitelline membrane supports the hypothesis that sperm-oocyte interactions in the bovine are mediated by integrins., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, 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bone resorption;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1MTN1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEW1-1", "uniprot_id": [ { "id": "F1MEW1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEW1", "type": "external" } ], "mass": 89145.0, "length": 772, "protein_name": "Semaphorin 3A", "gene_name": "SEMA3A", "organism": "Bovine", "refseq_name": "semaphorin-3A precursor", "refseq_ac": [ { "id": "NP_001263630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263630", "type": "external" } ], "gene_names_uniprotkb": "SEMA3A", "gene_names_refseq": "SEMA3A", "protein_names_uniprotkb": "Semaphorin 3A", "protein_names_refseq": "sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; semaphorin-3A precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:537777); (R-BTA-399954); (R-BTA-399955); (R-BTA-399956)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0007411 axon guidance;GO:0048841 regulation of axon extension involved in axon guidance;GO:0021772 olfactory bulb development;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEW1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MH60-1", "uniprot_id": [ { "id": "F1MH60_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MH60", "type": "external" } ], "mass": 50306.0, "length": 443, "protein_name": "Sprouty related EVH1 domain containing 1", "gene_name": "SPRED1", "organism": "Bovine", "refseq_name": "sprouty-related, EVH1 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001179445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179445", "type": "external" } ], "gene_names_uniprotkb": "SPRED1", "gene_names_refseq": "SPRED1", "protein_names_uniprotkb": "Sprouty related EVH1 domain containing 1", "protein_names_refseq": "sprouty-related, EVH1 domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:519882)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005173 stem cell factor receptor binding;GO:0019901 protein kinase binding;GO:0004860 protein kinase inhibitor activity;GO:0019902 phosphatase binding;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:1902532 negative regulation of intracellular signal transduction;GO:0046580 negative regulation of Ras protein signal transduction;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MH60-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHJ2-1", "uniprot_id": [ { "id": "MAEA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHJ2", "type": "external" } ], "mass": 49396.0, "length": 434, "protein_name": "E3 ubiquitin-protein transferase MAEA", "gene_name": "MAEA", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein transferase MAEA", "refseq_ac": [ { "id": "NP_001029587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029587", "type": "external" } ], "gene_names_uniprotkb": "MAEA", "gene_names_refseq": "MAEA", "protein_names_uniprotkb": "E3 ubiquitin-protein transferase MAEA; 2.3.2.27; Macrophage erythroblast attacher", "protein_names_refseq": "E3 ubiquitin-protein transferase MAEA", "tax_id": 9913, "disease": "", "pathway": " (bta:511956); (R-BTA-9861718)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7E3P9", "ec_number_list": [ { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0007155 cell adhesion;GO:0033033 negative regulation of myeloid cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3MHJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZBH0-1", "uniprot_id": [ { "id": "TCPB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3ZBH0", "type": "external" } ], "mass": 57475.0, "length": 535, "protein_name": "T-complex protein 1 subunit beta", "gene_name": "CCT2", "organism": "Bovine", "refseq_name": "T-complex protein 1 subunit beta", "refseq_ac": [ { "id": "NP_001029411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029411", "type": "external" } ], "gene_names_uniprotkb": "CCT2", "gene_names_refseq": "CCT2", "protein_names_uniprotkb": "T-complex protein 1 subunit beta; 3.6.1.-; CCT-beta; TCP-1-beta", "protein_names_refseq": "CCT-beta; T-complex protein 1 subunit beta; TCP-1-beta; chaperonin containing TCP1, subunit 2 (beta)", "tax_id": 9913, "disease": "", "pathway": " (bta:505313); (R-BTA-390471); (R-BTA-5620922); (R-BTA-6798695); (R-BTA-6814122); (R-BTA-9013418); (R-BTA-9013422)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005874 microtubule;GO:0044297 cell body;GO:0005832 chaperonin-containing T-complex;GO:0002199 zona pellucida receptor complex", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding;GO:1904874 positive regulation of telomerase RNA localization to Cajal body", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3ZBH0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHL4-1", "uniprot_id": [ { "id": "SAHH_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHL4", "type": "external" } ], "mass": 47638.0, "length": 432, "protein_name": "Adenosylhomocysteinase", "gene_name": "AHCY", "organism": "Bovine", "refseq_name": "adenosylhomocysteinase", "refseq_ac": [ { "id": "NP_001029487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029487", "type": "external" } ], "gene_names_uniprotkb": "AHCY", "gene_names_refseq": "AHCY", "protein_names_uniprotkb": "Adenosylhomocysteinase; 3.13.2.1; AdoHcyase; S-adenosyl-L-homocysteine hydrolase", "protein_names_refseq": "S-adenosyl-L-homocysteine hydrolase; S-adenosylhomocysteine hydrolase; adenosylhomocysteinase; adoHcyase", "tax_id": 9913, "disease": "", "pathway": " (bta:508158); (R-BTA-156581); (R-BTA-1614635)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (By similarity). Binds copper ions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine. Binds copper ions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D9B8", "ec_number_list": [ { "id": "3.13.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.13.2.1", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0004013 adenosylhomocysteinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0042470 melanosome", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0033353 S-adenosylmethionine cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3MHL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32L09-1", "uniprot_id": [ { "id": "SHFL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32L09", "type": "external" } ], "mass": 33205.0, "length": 290, "protein_name": "Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog", "gene_name": "SHFL", "organism": "Bovine", "refseq_name": "shiftless antiviral inhibitor of ribosomal frameshifting protein homolog", "refseq_ac": [ { "id": "NP_001033270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033270", "type": "external" } ], "gene_names_uniprotkb": "SHFL; RYDEN", "gene_names_refseq": "C7H19orf66; RyDEN; SHFL", "protein_names_uniprotkb": "Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog; Repressor of yield of DENV protein homolog; RyDEN; SHFL", "protein_names_refseq": "UPF0515 protein C19orf66 homolog; chromosome 7 C19orf66 homolog; repressor of yield of DENV protein homolog; shiftless antiviral inhibitor of ribosomal frameshifting protein homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:539087)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (By similarity). May exhibit antiviral activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003723 RNA binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0034341 response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32L09-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHN8-1", "uniprot_id": [ { "id": "TRM5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHN8", "type": "external" } ], "mass": 56954.0, "length": 497, "protein_name": "tRNA (guanine(37)-N(1))-methyltransferase", "gene_name": "TRMT5", "organism": "Bovine", "refseq_name": "tRNA (guanine(37)-N(1))-methyltransferase", "refseq_ac": [ { "id": "NP_001029737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029737", "type": "external" } ], "gene_names_uniprotkb": "TRMT5; TRM5", "gene_names_refseq": "TRMT5", "protein_names_uniprotkb": "tRNA (guanine(37)-N(1))-methyltransferase; 2.1.1.228; M1G-methyltransferase; tRNA [GM37] methyltransferase; tRNA methyltransferase 5 homolog", "protein_names_refseq": "M1G-methyltransferase; TRM5 tRNA methyltransferase 5 homolog; tRNA (guanine(37)-N(1))-methyltransferase; tRNA (guanine(37)-N1)-methyltransferase; tRNA (guanine-N(1)-)-methyltransferase; tRNA [GM37] methyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:528221)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding., [UniProtKB, HAMAP, UniProtKB]; Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding., [UniProtKB, UniProtKB]; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.228", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.228", "type": "external" } ], "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0002939 tRNA N1-guanine methylation;GO:0070901 mitochondrial tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHN8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SX40-1", "uniprot_id": [ { "id": "PDLI7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SX40", "type": "external" } ], "mass": 46433.0, "length": 424, "protein_name": "PDZ and LIM domain protein 7", "gene_name": "DBN1; PDLIM7", "organism": "Bovine", "refseq_name": "PDZ and LIM domain protein 7 isoform 1", "refseq_ac": [ { "id": "NP_001017947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017947", "type": "external" } ], "gene_names_uniprotkb": "DBN1; PDLIM7; PDLIM7", "gene_names_refseq": "PDLIM7", "protein_names_uniprotkb": "PDZ and LIM domain protein 7", "protein_names_refseq": "PDZ and LIM domain 7 (enigma); PDZ and LIM domain protein 7 isoform 1; PDZ and LIM domain protein 7; enigma protein", "tax_id": 9913, "disease": "", "pathway": " (bta:533851); (R-BTA-8853659)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5E9L1", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005912 adherens junction;GO:0001725 stress fiber;GO:0030018 Z disc;GO:0031941 filamentous actin;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007507 heart development;GO:0030154 cell differentiation;GO:0030036 actin cytoskeleton organization;GO:0001503 ossification;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SX40-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWY0-1", "uniprot_id": [ { "id": "RN183_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SWY0", "type": "external" } ], "mass": 21492.0, "length": 188, "protein_name": "E3 ubiquitin-protein ligase RNF183", "gene_name": "RNF183", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase RNF183", "refseq_ac": [ { "id": "NP_001030499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030499", "type": "external" } ], "gene_names_uniprotkb": "RNF183", "gene_names_refseq": "RNF183", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF183; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF183; probable E3 ubiquitin-protein ligase RNF183", "tax_id": 9913, "disease": "", "pathway": " (bta:539200)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033106 cis-Golgi network membrane;GO:0005794 Golgi apparatus;GO:0005764 lysosome", "go_biological_process": "GO:0006915 apoptotic process;GO:0016567 protein ubiquitination;GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWY0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LH7-1", "uniprot_id": [ { "id": "NB5R4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LH7", "type": "external" } ], "mass": 59274.0, "length": 520, "protein_name": "Cytochrome b5 reductase 4", "gene_name": "CYB5R4", "organism": "Bovine", "refseq_name": "cytochrome b5 reductase 4", "refseq_ac": [ { "id": "NP_001033248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033248", "type": "external" } ], "gene_names_uniprotkb": "CYB5R4", "gene_names_refseq": "CYB5R4", "protein_names_uniprotkb": "Cytochrome b5 reductase 4; 1.6.2.2; Flavohemoprotein b5/b5R; b5+b5R; cb5/cb5R", "protein_names_refseq": "b5+b5R; cb5/cb5R; cytochrome b5 reductase 4; flavohemoprotein b5/b5R", "tax_id": 9913, "disease": "", "pathway": " (bta:533608); (R-BTA-1237044)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS) (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0090524 cytochrome-b5 reductase activity, acting on NADH", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006801 superoxide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32LH7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SX23-1", "uniprot_id": [ { "id": "LONP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SX23", "type": "external" } ], "mass": 94310.0, "length": 852, "protein_name": "Lon protease homolog 2, peroxisomal", "gene_name": "LONP2", "organism": "Bovine", "refseq_name": "lon protease homolog 2, peroxisomal", "refseq_ac": [ { "id": "NP_001029895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029895", "type": "external" } ], "gene_names_uniprotkb": "LONP2", "gene_names_refseq": "LONP2", "protein_names_uniprotkb": "Lon protease homolog 2, peroxisomal; 3.4.21.53; Lon protease 2; Lon protease-like protein 2; Peroxisomal Lon protease", "protein_names_refseq": "lon protease 2; lon protease homolog 2, peroxisomal; lon protease-like protein 2; peroxisomal Lon protease homolog 2", "tax_id": 9913, "disease": "", "pathway": " (bta:541085); (R-BTA-9033241)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0004252 serine-type endopeptidase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004176 ATP-dependent peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0016485 protein processing;GO:0006625 protein targeting to peroxisome;GO:0016558 protein import into peroxisome matrix;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0031998 regulation of fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SX23-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYY2-1", "uniprot_id": [ { "id": "TPST2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYY2", "type": "external" } ], "mass": 41967.0, "length": 377, "protein_name": "Protein-tyrosine sulfotransferase 2", "gene_name": "TPST2", "organism": "Bovine", "refseq_name": "protein-tyrosine sulfotransferase 2", "refseq_ac": [ { "id": "NP_001030506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030506", "type": "external" } ], "gene_names_uniprotkb": "TPST2", "gene_names_refseq": "TPST2", "protein_names_uniprotkb": "Protein-tyrosine sulfotransferase 2; 2.8.2.20; TPST-2; Tyrosylprotein sulfotransferase 2", "protein_names_refseq": "TPST-2; protein-tyrosine sulfotransferase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:540183); (R-BTA-156584); (R-BTA-163841)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22183414", "class_list": "", "function": "Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TPSP1 and TPSP2 provide an important posttranslational modification for vision., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.20", "type": "external" } ], "go_molecular_function": "GO:0008476 protein-tyrosine sulfotransferase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005783 endoplasmic reticulum;GO:0005796 Golgi lumen;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006478 peptidyl-tyrosine sulfation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SYY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32KY1-1", "uniprot_id": [ { "id": "DRC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32KY1", "type": "external" } ], "mass": 84070.0, "length": 712, "protein_name": "Dynein regulatory complex protein 1", "gene_name": "DRC1", "organism": "Bovine", "refseq_name": "dynein regulatory complex protein 1", "refseq_ac": [ { "id": "NP_001032680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032680", "type": "external" } ], "gene_names_uniprotkb": "DRC1; CCDC164", "gene_names_refseq": "C11H2orf39; C2orf39; CCDC164; DRC1", "protein_names_uniprotkb": "Dynein regulatory complex protein 1; Coiled-coil domain-containing protein 164", "protein_names_refseq": "coiled-coil domain containing 164; coiled-coil domain-containing protein 164; dynein regulatory complex protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:509524)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0V7L5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005930 axoneme;GO:0005858 axonemal dynein complex;GO:0005829 cytosol;GO:0036126 sperm flagellum", "go_biological_process": "GO:0060285 cilium-dependent cell motility;GO:0070286 axonemal dynein complex assembly;GO:0003352 regulation of cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32KY1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7N0-1", "uniprot_id": [ { "id": "CAD13_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3B7N0", "type": "external" } ], "mass": 78197.0, "length": 713, "protein_name": "Cadherin-13", "gene_name": "CDH13", "organism": "Bovine", "refseq_name": "cadherin-13 precursor", "refseq_ac": [ { "id": "NP_001030354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030354", "type": "external" } ], "gene_names_uniprotkb": "CDH13", "gene_names_refseq": "CDH13", "protein_names_uniprotkb": "Cadherin-13", "protein_names_refseq": "cadherin 13, H-cadherin (heart); cadherin-13 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:512302); (R-BTA-418990)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0042802 identical protein binding;GO:0030169 low-density lipoprotein particle binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0016342 catenin complex;GO:0098552 side of membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B7N0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZP8-1", "uniprot_id": [ { "id": "TAD2A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZP8", "type": "external" } ], "mass": 51469.0, "length": 443, "protein_name": "Transcriptional adapter 2-alpha", "gene_name": "TADA2A", "organism": "Bovine", "refseq_name": "transcriptional adapter 2-alpha", "refseq_ac": [ { "id": "NP_001029416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029416", "type": "external" } ], "gene_names_uniprotkb": "TADA2A; TADA2L", "gene_names_refseq": "TADA2A; TADA2L", "protein_names_uniprotkb": "Transcriptional adapter 2-alpha; ADA2-like protein; Transcriptional adapter 2-like", "protein_names_refseq": "ADA2-like protein; transcriptional adapter 2-alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:505401); (R-BTA-9772755)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0070461 SAGA-type complex;GO:0005634 nucleus;GO:0072686 mitotic spindle;GO:0140672 ATAC complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051726 regulation of cell cycle;GO:0045995 regulation of embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZP8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHN2-1", "uniprot_id": [ { "id": "CO9_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHN2", "type": "external" } ], "mass": 61998.0, "length": 548, "protein_name": "Complement component C9", "gene_name": "C9", "organism": "Bovine", "refseq_name": "complement component C9 precursor", "refseq_ac": [ { "id": "NP_001030441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030441", "type": "external" } ], "gene_names_uniprotkb": "C9", "gene_names_refseq": "C9", "protein_names_uniprotkb": "Complement component C9", "protein_names_refseq": "complement component 9; complement component C9 precursor; complement component C9", "tax_id": 9913, "disease": "", "pathway": " (bta:526766); (R-BTA-166665); (R-BTA-977606)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0031640 killing of cells of another organism;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation;GO:0006957 complement activation, alternative pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHN2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHM5-1", "uniprot_id": [ { "id": "TBB4B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHM5", "type": "external" } ], "mass": 49831.0, "length": 445, "protein_name": "Tubulin beta-4B chain", "gene_name": "TUBB2A; TUBB4B", "organism": "Bovine", "refseq_name": "tubulin beta-4B chain", "refseq_ac": [ { "id": "NP_001029835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029835", "type": "external" } ], "gene_names_uniprotkb": "TUBB2A; TUBB4B; TUBB2C; TUBB4B", "gene_names_refseq": "TUBB2A; TUBB2C; TUBB4B", "protein_names_uniprotkb": "Tubulin beta-4B chain; Tubulin beta-2C chain", "protein_names_refseq": "tubulin beta-2C chain; tubulin beta-4B chain; tubulin, beta 2A; tubulin, beta 2C", "tax_id": 9913, "disease": "", "pathway": " (bta:100295973); (bta:539149); (R-BTA-2132295); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-2565942); (R-BTA-3371497); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-5620924); (R-BTA-6798695); (R-BTA-6807878); (R-BTA-6811436); (R-BTA-8854518); (R-BTA-9646399); (R-BTA-9648025)", "pathway_count": 19, "publication_count": 6, "publication_id_list": "2207090;36541084;37327785;40651469;6504138;7704569", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:2207090, PubMed:6504138, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:2207090, PubMed:6504138, PubMed:7704569)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0097229 sperm end piece", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030317 flagellated sperm motility;GO:0000226 microtubule cytoskeleton organization;GO:0001764 neuron migration;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3MHM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32P99-1", "uniprot_id": [ { "id": "UBE2B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32P99", "type": "external" } ], "mass": 17312.0, "length": 152, "protein_name": "Ubiquitin-conjugating enzyme E2 B", "gene_name": "UBE2B", "organism": "Bovine", "refseq_name": "ubiquitin-conjugating enzyme E2 B", "refseq_ac": [ { "id": "NP_001032536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032536", "type": "external" } ], "gene_names_uniprotkb": "UBE2B", "gene_names_refseq": "UBE2B", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 B; 2.3.2.23; E2 ubiquitin-conjugating enzyme B; Ubiquitin carrier protein B; Ubiquitin-protein ligase B", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme B; ubiquitin carrier protein B; ubiquitin-conjugating enzyme E2 B; ubiquitin-conjugating enzyme E2B (RAD6 homolog); ubiquitin-protein ligase B", "tax_id": 9913, "disease": "", "pathway": " (bta:512207); (R-BTA-110314); (R-BTA-8866652); (R-BTA-8866654); (R-BTA-983168)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin-protein ligase (By similarity). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination (By similarity). Together with the E3 enzyme BRE1 (RNF20 and/or RNF40), plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1 (By similarity). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). May play a role in DNA repair (By similarity). Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164' (By similarity). In association with the E3 enzyme UBR4, is involved in N-end rule-dependent protein degradation (By similarity). May be involved in neurite outgrowth (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0033503 HULC complex;GO:0005737 cytoplasm;GO:0005657 replication fork", "go_biological_process": "GO:0006281 DNA repair;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0000209 protein polyubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32P99-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHI8-1", "uniprot_id": [ { "id": "TM10A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHI8", "type": "external" } ], "mass": 39573.0, "length": 338, "protein_name": "tRNA methyltransferase 10 homolog A", "gene_name": "TRMT10A", "organism": "Bovine", "refseq_name": "tRNA methyltransferase 10 homolog A", "refseq_ac": [ { "id": "NP_001030554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030554", "type": "external" } ], "gene_names_uniprotkb": "TRMT10A; RG9MTD2", "gene_names_refseq": "RG9MTD2; TRMT10A", "protein_names_uniprotkb": "tRNA methyltransferase 10 homolog A; 2.1.1.221; RNA (guanine-9-)-methyltransferase domain-containing protein 2; tRNA (guanine(9)-N(1))-methyltransferase TRMT10A", "protein_names_refseq": "RNA (guanine-9-) methyltransferase domain containing 2; RNA (guanine-9-)-methyltransferase domain-containing protein 2; tRNA (guanine(9)-N(1))-methyltransferase TRMT10A; tRNA methyltransferase 10 homolog A", "tax_id": 9913, "disease": "", "pathway": " (bta:616544)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.218", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0030488 tRNA methylation;GO:0002939 tRNA N1-guanine methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHI8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZM5-1", "uniprot_id": [ { "id": "NEUA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZM5", "type": "external" } ], "mass": 48438.0, "length": 434, "protein_name": "N-acylneuraminate cytidylyltransferase", "gene_name": "CMAS", "organism": "Bovine", "refseq_name": "N-acylneuraminate cytidylyltransferase", "refseq_ac": [ { "id": "NP_001030475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030475", "type": "external" } ], "gene_names_uniprotkb": "CMAS", "gene_names_refseq": "CMAS", "protein_names_uniprotkb": "N-acylneuraminate cytidylyltransferase; 2.7.7.43; CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase", "protein_names_refseq": "CMP-N-acetylneuraminic acid synthase; CMP-N-acetylneuraminic acid synthetase; CMP-NeuNAc synthase; CMP-NeuNAc synthetase; N-acylneuraminate cytidylyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:100336710); (R-BTA-4085001)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.43", "type": "external" } ], "go_molecular_function": "GO:0008781 N-acylneuraminate cytidylyltransferase activity;GO:0090632 N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity;GO:0090633 keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0006054 N-acetylneuraminate metabolic process;GO:0006055 CMP-N-acetylneuraminate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZM5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWY6-1", "uniprot_id": [ { "id": "STK25_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SWY6", "type": "external" } ], "mass": 48035.0, "length": 426, "protein_name": "Serine/threonine-protein kinase 25", "gene_name": "STK25", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase 25", "refseq_ac": [ { "id": "NP_001421692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421692", "type": "external" } ], "gene_names_uniprotkb": "STK25", "gene_names_refseq": "STK25", "protein_names_uniprotkb": "Serine/threonine-protein kinase 25; 2.7.11.1", "protein_names_refseq": "serine/threonine kinase 25 (STE20 homolog, yeast); serine/threonine-protein kinase 25", "tax_id": 9913, "disease": "", "pathway": " (bta:373543)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB]; Oxidant stress-activated serine/threonine kinase that plays a role in metabolic homeostasis, neuronal polarization, cell migration, Golgi organization, apoptosis or innate immunity. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Functions as an inhibitor of the PKA pathway by affecting phosphorylation of the PRKAR1A regulatory subunit, which in turn suppresses the kinase activity of the catalytic subunit. Positively regulates the TLR signaling by directly phosphorylating the transcription factor IRF5., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6V9V8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0090443 FAR/SIN/STRIPAK complex", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0051645 Golgi localization;GO:0051683 establishment of Golgi localization;GO:0090168 Golgi reassembly;GO:0036481 intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWY6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T0F7-1", "uniprot_id": [ { "id": "MTPN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T0F7", "type": "external" } ], "mass": 12895.0, "length": 118, "protein_name": "Myotrophin", "gene_name": "MTPN", "organism": "Bovine", "refseq_name": "myotrophin", "refseq_ac": [ { "id": "NP_976238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976238", "type": "external" } ], "gene_names_uniprotkb": "MTPN", "gene_names_refseq": "MTPN", "protein_names_uniprotkb": "Myotrophin", "protein_names_refseq": "myotrophin", "tax_id": 9913, "disease": "", "pathway": " (bta:541099)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0010557 positive regulation of macromolecule biosynthetic process;GO:2000812 regulation of barbed-end actin filament capping;GO:0030307 positive regulation of cell growth;GO:0051247 positive regulation of protein metabolic process;GO:0010613 positive regulation of cardiac muscle hypertrophy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T0F7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PC9-1", "uniprot_id": [ { "id": "AR2BP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32PC9", "type": "external" } ], "mass": 18772.0, "length": 163, "protein_name": "ADP-ribosylation factor-like protein 2-binding protein", "gene_name": "ARL2BP", "organism": "Bovine", "refseq_name": "ADP-ribosylation factor-like protein 2-binding protein", "refseq_ac": [ { "id": "NP_001069742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069742", "type": "external" } ], "gene_names_uniprotkb": "ARL2BP; BART1", "gene_names_refseq": "ARL2BP", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 2-binding protein; ARF-like 2-binding protein; Binder of ARF2 protein 1", "protein_names_refseq": "ADP-ribosylation factor-like 2 binding protein; ADP-ribosylation factor-like protein 2-binding protein; ARF-like 2-binding protein; binder of ARF2 protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:613462); (R-BTA-83936)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10488091;11809823", "class_list": "", "function": "Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IFR7", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein;GO:0051457 maintenance of protein location in nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q32PC9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZC4-1", "uniprot_id": [ { "id": "NSF1C_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZC4", "type": "external" } ], "mass": 40654.0, "length": 370, "protein_name": "NSFL1 cofactor p47", "gene_name": "NSFL1C", "organism": "Bovine", "refseq_name": "NSFL1 cofactor p47", "refseq_ac": [ { "id": "NP_001029729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029729", "type": "external" } ], "gene_names_uniprotkb": "NSFL1C", "gene_names_refseq": "NSFL1C", "protein_names_uniprotkb": "NSFL1 cofactor p47; p97 cofactor p47", "protein_names_refseq": "NSFL1 (p97) cofactor (p47); NSFL1 cofactor p47; p97 cofactor p47", "tax_id": 9913, "disease": "", "pathway": " (bta:526612); (R-BTA-9013407)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:1990730 VCP-NSFL1C complex;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005795 Golgi stack", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0000045 autophagosome assembly;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061025 membrane fusion;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZC4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHG1-1", "uniprot_id": [ { "id": "SPTC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHG1", "type": "external" } ], "mass": 52788.0, "length": 473, "protein_name": "Serine palmitoyltransferase 1", "gene_name": "SPTLC1", "organism": "Bovine", "refseq_name": "serine palmitoyltransferase 1", "refseq_ac": [ { "id": "NP_001029921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029921", "type": "external" } ], "gene_names_uniprotkb": "SPTLC1", "gene_names_refseq": "SPTLC1", "protein_names_uniprotkb": "Serine palmitoyltransferase 1; 2.3.1.50; LCB 1; Long chain base biosynthesis protein 1; SPT 1; SPT1; Serine-palmitoyl-CoA transferase 1", "protein_names_refseq": "LCB 1; SPT 1; SPT1; long chain base biosynthesis protein 1; serine palmitoyltransferase 1; serine palmitoyltransferase subunit 1; serine-palmitoyl-CoA transferase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:614165); (R-BTA-1660661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Required for adipocyte cell viability and metabolic homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.50", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.50", "type": "external" } ], "go_molecular_function": "GO:0004758 serine C-palmitoyltransferase activity;GO:0030170 pyridoxal phosphate binding", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0006665 sphingolipid metabolic process;GO:0046512 sphingosine biosynthetic process;GO:1904649 regulation of fat cell apoptotic process;GO:0006686 sphingomyelin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHG1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZG6-1", "uniprot_id": [ { "id": "CBAR1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZG6", "type": "external" } ], "mass": 33524.0, "length": 288, "protein_name": "CBY1-interacting BAR domain-containing protein 1", "gene_name": "CIBAR1", "organism": "Bovine", "refseq_name": "CBY1-interacting BAR domain-containing protein 1", "refseq_ac": [ { "id": "NP_001030519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030519", "type": "external" } ], "gene_names_uniprotkb": "CIBAR1; FAM92A1; FAM92A", "gene_names_refseq": "CIBAR1; FAM92A1; FAM92A", "protein_names_uniprotkb": "CBY1-interacting BAR domain-containing protein 1", "protein_names_refseq": "CBY1-interacting BAR domain-containing protein 1; family with sequence similarity 92 member A1; protein FAM92A1", "tax_id": 9913, "disease": "", "pathway": " (bta:614070)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a critical role in regulating mitochondrial ultrastructure and function by maintaining the integrity of mitochondrial morphology, particularly the organization of cristae (By similarity). Preferentially binds to negatively charged phospholipids like cardiolipin and phosphatidylinositol 4,5-bisphosphate enhancing its interaction with mitochondrial membranes (By similarity). Induces membrane curvature and tubulation, which are critical for maintaining mitochondrial ultrastructure and the organization of cristae (By similarity). Plays a crucial role in ciliogenesis (By similarity). May play a role in limb development through its role in ciliogenesis (By similarity). Plays a key role in the correct positioning of the annulus, a septin-based ring structure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (By similarity). This positioning is essential for proper sperm motility and function (By similarity). Interacts with CBY3 to form a complex which localizes to the curved membrane region of the flagellar pocket (By similarity). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (By similarity). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005929 cilium", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0060271 cilium assembly;GO:0035108 limb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZG6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B8S0-1", "uniprot_id": [ { "id": "NH2L1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3B8S0", "type": "external" } ], "mass": 14174.0, "length": 128, "protein_name": "NHP2-like protein 1", "gene_name": "SNU13", "organism": "Bovine", "refseq_name": "NHP2-like protein 1", "refseq_ac": [ { "id": "NP_001070472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070472", "type": "external" } ], "gene_names_uniprotkb": "SNU13; NHP2L1", "gene_names_refseq": "NHP2L1; SNU13", "protein_names_uniprotkb": "NHP2-like protein 1; High mobility group-like nuclear protein 2 homolog 1; U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 tri-snRNP 15.5 kDa protein", "protein_names_refseq": "NHP2 non-histone chromosome protein 2-like 1; NHP2-like protein 1; SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5); U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 tri-snRNP 15.5 kDa protein; high mobility group-like nuclear protein 2 homolog 1", "tax_id": 9913, "disease": "", "pathway": " (bta:767931); (R-BTA-6791226); (R-BTA-72163)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Common component of the spliceosome and rRNA processing machinery., [UniProtKB, UniProtKB, UniProtKB]; Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0030622 U4atac snRNA binding;GO:0034512 box C/D sno(s)RNA binding;GO:0030621 U4 snRNA binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0071011 precatalytic spliceosome;GO:0031428 box C/D methylation guide snoRNP complex;GO:0005690 U4atac snRNP", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA;GO:0042254 ribosome biogenesis;GO:0000492 box C/D snoRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B8S0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZH6-1", "uniprot_id": [ { "id": "TTLL9_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZH6", "type": "external" } ], "mass": 54111.0, "length": 461, "protein_name": "Probable tubulin polyglutamylase TTLL9", "gene_name": "TTLL9", "organism": "Bovine", "refseq_name": "probable tubulin polyglutamylase TTLL9", "refseq_ac": [ { "id": "NP_001030455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030455", "type": "external" } ], "gene_names_uniprotkb": "TTLL9", "gene_names_refseq": "TTLL9", "protein_names_uniprotkb": "Probable tubulin polyglutamylase TTLL9; 6.3.2.-; Tubulin--tyrosine ligase-like protein 9", "protein_names_refseq": "probable tubulin polyglutamylase TTLL9; tubulin tyrosine ligase-like family, member 9; tubulin--tyrosine ligase-like protein 9", "tax_id": 9913, "disease": "", "pathway": " (bta:529246)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins. Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity. Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0106438 protein-glutamic acid ligase activity, elongating", "go_cellular_component": "GO:0005874 microtubule;GO:0036064 ciliary basal body", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZH6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWZ6-1", "uniprot_id": [ { "id": "SBDS_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SWZ6", "type": "external" } ], "mass": 28718.0, "length": 250, "protein_name": "Ribosome maturation protein SBDS", "gene_name": "SBDS", "organism": "Bovine", "refseq_name": "ribosome maturation protein SBDS", "refseq_ac": [ { "id": "NP_001029611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029611", "type": "external" } ], "gene_names_uniprotkb": "SBDS", "gene_names_refseq": "SBDS", "protein_names_uniprotkb": "Ribosome maturation protein SBDS; Shwachman-Bodian-Diamond syndrome protein homolog", "protein_names_refseq": "SBDS, ribosome assembly guanine nucleotide exchange factor; ribosome maturation protein SBDS; shwachman-Bodian-Diamond syndrome protein homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:513237)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019843 rRNA binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation;GO:0006364 rRNA processing;GO:0030282 bone mineralization;GO:0007052 mitotic spindle organization;GO:0048539 bone marrow development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWZ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32S26-1", "uniprot_id": [ { "id": "BRD2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32S26", "type": "external" } ], "mass": 88122.0, "length": 803, "protein_name": "Bromodomain-containing protein 2", "gene_name": "BRD2", "organism": "Bovine", "refseq_name": "bromodomain-containing protein 2", "refseq_ac": [ { "id": "NP_001039331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039331", "type": "external" } ], "gene_names_uniprotkb": "BRD2", "gene_names_refseq": "BRD2", "protein_names_uniprotkb": "Bromodomain-containing protein 2", "protein_names_refseq": "bromodomain-containing protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:505358)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16573526", "class_list": "", "function": "Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures. Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation. Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation. Also recognizes and binds acetylated non-histone proteins, such as STAT3. Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin. In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation. Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140566 histone reader activity;GO:0140012 histone H4K5ac reader activity;GO:0004674 protein serine/threonine kinase activity;GO:0140033 acetylation-dependent protein binding;GO:0140011 histone H4K12ac reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32S26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LN1-1", "uniprot_id": [ { "id": "UBE2H_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LN1", "type": "external" } ], "mass": 20655.0, "length": 183, "protein_name": "Ubiquitin-conjugating enzyme E2 H", "gene_name": "UBE2H", "organism": "Bovine", "refseq_name": "ubiquitin-conjugating enzyme E2 H", "refseq_ac": [ { "id": "NP_001032703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032703", "type": "external" } ], "gene_names_uniprotkb": "UBE2H", "gene_names_refseq": "E2-20K; UBCH2; UBE2H", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 H; (E3-independent) E2 ubiquitin-conjugating enzyme H; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme H; Ubiquitin carrier protein H; Ubiquitin-protein ligase H", "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme H; E2 ubiquitin-conjugating enzyme H; ubiquitin carrier protein H; ubiquitin-conjugating enzyme E2 H; ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast); ubiquitin-conjugating enzyme E2H (homologous to yeast UBC8); ubiquitin-protein ligase H", "tax_id": 9913, "disease": "", "pathway": " (bta:539313); (R-BTA-8866652); (R-BTA-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0070979 protein K11-linked ubiquitination;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32LN1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LM6-1", "uniprot_id": [ { "id": "LIN7A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LM6", "type": "external" } ], "mass": 25997.0, "length": 233, "protein_name": "Protein lin-7 homolog A", "gene_name": "LIN7A", "organism": "Bovine", "refseq_name": "protein lin-7 homolog A", "refseq_ac": [ { "id": "NP_001073070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073070", "type": "external" } ], "gene_names_uniprotkb": "LIN7A", "gene_names_refseq": "LIN7A", "protein_names_uniprotkb": "Protein lin-7 homolog A; Lin-7A", "protein_names_refseq": "lin-7A; protein lin-7 homolog A", "tax_id": 9913, "disease": "", "pathway": " (bta:528379); (R-BTA-212676)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0097016 L27 domain binding", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane;GO:0045202 synapse;GO:0098793 presynapse", "go_biological_process": "GO:0015031 protein transport;GO:0007269 neurotransmitter secretion;GO:0006887 exocytosis;GO:0048489 synaptic vesicle transport;GO:0008582 regulation of synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32LM6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZX4-1", "uniprot_id": [ { "id": "CAH3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZX4", "type": "external" } ], "mass": 29370.0, "length": 260, "protein_name": "Carbonic anhydrase 3", "gene_name": "CA3", "organism": "Bovine", "refseq_name": "carbonic anhydrase 3", "refseq_ac": [ { "id": "NP_001029609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029609", "type": "external" } ], "gene_names_uniprotkb": "CA3", "gene_names_refseq": "CA3", "protein_names_uniprotkb": "Carbonic anhydrase 3; 4.2.1.1; CA-III; Carbonate dehydratase III; Carbonic anhydrase III", "protein_names_refseq": "CA-III; carbonate dehydratase III; carbonic anhydrase 3; carbonic anhydrase III, muscle specific", "tax_id": 9913, "disease": "", "pathway": " (bta:513212); (R-BTA-1475029)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZX4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32L60-1", "uniprot_id": [ { "id": "TRI13_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32L60", "type": "external" } ], "mass": 47078.0, "length": 407, "protein_name": "E3 ubiquitin-protein ligase TRIM13", "gene_name": "TRIM13", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase TRIM13", "refseq_ac": [ { "id": "NP_001033254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033254", "type": "external" } ], "gene_names_uniprotkb": "TRIM13; RFP2", "gene_names_refseq": "RFP2; TRIM13", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM13; 2.3.2.27; Putative tumor suppressor RFP2; RING-type E3 ubiquitin transferase TRIM13; Ret finger protein 2; Tripartite motif-containing protein 13", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM13; RING-type E3 ubiquitin transferase TRIM13; putative tumor suppressor RFP2; ret finger protein 2; tripartite motif-containing protein 13", "tax_id": 9913, "disease": "", "pathway": " (bta:535190)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation. Participates as well in T-cell receptor-mediated NF-kappa-B activation. In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MGY4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0097038 perinuclear endoplasmic reticulum", "go_biological_process": "GO:0045087 innate immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0016567 protein ubiquitination;GO:0016239 positive regulation of macroautophagy;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32L60-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SX21-1", "uniprot_id": [ { "id": "CLK3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SX21", "type": "external" } ], "mass": 58628.0, "length": 490, "protein_name": "Dual specificity protein kinase CLK3", "gene_name": "CLK3", "organism": "Bovine", "refseq_name": "dual specificity protein kinase CLK3", "refseq_ac": [ { "id": "NP_001029420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029420", "type": "external" } ], "gene_names_uniprotkb": "CLK3", "gene_names_refseq": "CLK3", "protein_names_uniprotkb": "Dual specificity protein kinase CLK3; 2.7.12.1; CDC-like kinase 3", "protein_names_refseq": "dual specificity protein kinase CLK3", "tax_id": 9913, "disease": "", "pathway": " (bta:505499)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0001669 acrosomal vesicle;GO:0005654 nucleoplasm", "go_biological_process": "GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SX21-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHY7-1", "uniprot_id": [ { "id": "RM10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHY7", "type": "external" } ], "mass": 29328.0, "length": 262, "protein_name": "Large ribosomal subunit protein uL10m", "gene_name": "MRPL10", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein uL10m", "refseq_ac": [ { "id": "NP_001179324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179324", "type": "external" } ], "gene_names_uniprotkb": "MRPL10", "gene_names_refseq": "L10mt; MRP-L10; MRPL10", "protein_names_uniprotkb": "Large ribosomal subunit protein uL10m; 39S ribosomal protein L10, mitochondrial; L10mt; MRP-L10", "protein_names_refseq": "39S ribosomal protein L10, mitochondrial; large ribosomal subunit protein uL10m", "tax_id": 9913, "disease": "", "pathway": " (bta:515014); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279069;11551941", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3MHY7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YDM1-1", "uniprot_id": [ { "id": "ARL1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2YDM1", "type": "external" } ], "mass": 20428.0, "length": 181, "protein_name": "ADP-ribosylation factor-like protein 1", "gene_name": "ARL1", "organism": "Bovine", "refseq_name": "ADP-ribosylation factor-like protein 1", "refseq_ac": [ { "id": "NP_001039694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039694", "type": "external" } ], "gene_names_uniprotkb": "ARL1", "gene_names_refseq": "ARL1", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 1", "protein_names_refseq": "ADP-ribosylation factor-like 1; ADP-ribosylation factor-like protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:517345); (R-BTA-6811440)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex. Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008047 enzyme activator activity;GO:0046872 metal ion binding;GO:1990583 phospholipase D activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0009404 toxin metabolic process;GO:0042147 retrograde transport, endosome to Golgi;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2YDM1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3LUH2-1", "uniprot_id": [ { "id": "CLC6A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3LUH2", "type": "external" } ], "mass": 23738.0, "length": 206, "protein_name": "C-type lectin domain family 6 member A", "gene_name": "CLEC6A", "organism": "Bovine", "refseq_name": "C-type lectin domain family 6 member A", "refseq_ac": [ { "id": "NP_001029651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029651", "type": "external" } ], "gene_names_uniprotkb": "CLEC6A; DECTIN2", "gene_names_refseq": "CLEC6A", "protein_names_uniprotkb": "C-type lectin domain family 6 member A; DC-associated C-type lectin 2; Dectin-2; Dendritic cell-associated C-type lectin 2", "protein_names_refseq": "C-type lectin domain family 6 member A; DC-associated C-type lectin 2; dectin-2; dendritic cell-associated C-type lectin 2", "tax_id": 9913, "disease": "", "pathway": " (bta:514979); (R-BTA-5621480); (R-BTA-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16213030", "class_list": "", "function": "Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (By similarity). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Also recognizes, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3LUH1", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005537 D-mannose binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0001819 positive regulation of cytokine production;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0002250 adaptive immune response;GO:0050832 defense response to fungus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3LUH2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBU2-1", "uniprot_id": [ { "id": "TMX2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBU2", "type": "external" } ], "mass": 34029.0, "length": 296, "protein_name": "Thioredoxin-related transmembrane protein 2", "gene_name": "TMX2", "organism": "Bovine", "refseq_name": "thioredoxin-related transmembrane protein 2", "refseq_ac": [ { "id": "NP_001015558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015558", "type": "external" } ], "gene_names_uniprotkb": "TMX2; TXNDC14", "gene_names_refseq": "TMX2; TXNDC14", "protein_names_uniprotkb": "Thioredoxin-related transmembrane protein 2; Thioredoxin domain-containing protein 14", "protein_names_refseq": "thioredoxin domain containing 14; thioredoxin domain-containing protein 14; thioredoxin-related transmembrane protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:509244)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5E937", "ec_number_list": [], "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2TBU2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBR7-1", "uniprot_id": [ { "id": "CENPS_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBR7", "type": "external" } ], "mass": 15951.0, "length": 138, "protein_name": "Centromere protein S", "gene_name": "CENPS", "organism": "Bovine", "refseq_name": "centromere protein S", "refseq_ac": [ { "id": "NP_001033665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033665", "type": "external" } ], "gene_names_uniprotkb": "CENPS; APITD1; FAAP16; MHF1", "gene_names_refseq": "APITD1; CENP-S; CENPS", "protein_names_uniprotkb": "Centromere protein S; Apoptosis-inducing TAF9-like domain-containing protein 1 homolog; CENP-S; FANCM-interacting histone fold protein 1", "protein_names_refseq": "FANCM-interacting histone fold protein 1; apoptosis-inducing TAF9-like domain-containing protein 1 homolog; apoptosis-inducing, TAF9-like domain 1; centromere protein S", "tax_id": 9913, "disease": "", "pathway": " (bta:613732); (R-BTA-141430); (R-BTA-141444); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-5663220); (R-BTA-606279); (R-BTA-6783310); (R-BTA-9648025); (R-BTA-9833482)", "pathway_count": 10, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0071821 FANCM-MHF complex;GO:0000776 kinetochore", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0006281 DNA repair;GO:0051301 cell division;GO:0006974 DNA damage response;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBR7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBR8-1", "uniprot_id": [ { "id": "CALR3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBR8", "type": "external" } ], "mass": 44512.0, "length": 384, "protein_name": "Calreticulin-3", "gene_name": "CALR3", "organism": "Bovine", "refseq_name": "calreticulin-3 precursor", "refseq_ac": [ { "id": "NP_001033603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033603", "type": "external" } ], "gene_names_uniprotkb": "CALR3", "gene_names_refseq": "CALR3", "protein_names_uniprotkb": "Calreticulin-3; Calsperin", "protein_names_refseq": "calreticulin-3 precursor; calsperin", "tax_id": 9913, "disease": "", "pathway": " (bta:508555)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006457 protein folding;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBR8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBT5-1", "uniprot_id": [ { "id": "RNH2A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBT5", "type": "external" } ], "mass": 33300.0, "length": 299, "protein_name": "Ribonuclease H2 subunit A", "gene_name": "RNASEH2A", "organism": "Bovine", "refseq_name": "ribonuclease H2 subunit A", "refseq_ac": [ { "id": "NP_001033623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033623", "type": "external" } ], "gene_names_uniprotkb": "RNASEH2A", "gene_names_refseq": "RNASEH2A", "protein_names_uniprotkb": "Ribonuclease H2 subunit A; 3.1.26.4; RNase H2 subunit A; RNase HI large subunit; Ribonuclease HI large subunit; Ribonuclease HI subunit A", "protein_names_refseq": "RNase H2 subunit A; RNase HI large subunit; ribonuclease H2 subunit A; ribonuclease HI large subunit; ribonuclease HI subunit A", "tax_id": 9913, "disease": "", "pathway": " (bta:512830)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9789007", "class_list": "", "function": "Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0032299 ribonuclease H2 complex", "go_biological_process": "GO:0006298 mismatch repair;GO:0043137 DNA replication, removal of RNA primer;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2TBT5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBU9-1", "uniprot_id": [ { "id": "RUVB2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBU9", "type": "external" } ], "mass": 51170.0, "length": 463, "protein_name": "RuvB-like 2", "gene_name": "RUVBL2", "organism": "Bovine", "refseq_name": "ruvB-like 2", "refseq_ac": [ { "id": "NP_001033615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033615", "type": "external" } ], "gene_names_uniprotkb": "RUVBL2", "gene_names_refseq": "RUVBL2", "protein_names_uniprotkb": "RuvB-like 2; 3.6.4.12", "protein_names_refseq": "ruvB-like 2", "tax_id": 9913, "disease": "", "pathway": " (bta:511048)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (By similarity). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (By similarity). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (By similarity). May also inhibit the transcriptional activity of ATF2 (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (By similarity). May play a role in regulating the composition of the U5 snRNP complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity;GO:0140296 general transcription initiation factor binding", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0031011 Ino80 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBU9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBW2-1", "uniprot_id": [ { "id": "COQ7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBW2", "type": "external" } ], "mass": 24361.0, "length": 217, "protein_name": "NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial", "gene_name": "COQ7", "organism": "Bovine", "refseq_name": "NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_001106712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106712", "type": "external" } ], "gene_names_uniprotkb": "COQ7", "gene_names_refseq": "COQ7", "protein_names_uniprotkb": "NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial; 1.14.13.253; 3-demethoxyubiquinone 3-hydroxylase (NADH); Timing protein clk-1 homolog; Ubiquinone biosynthesis monooxygenase COQ7", "protein_names_refseq": "3-demethoxyubiquinone 3-hydroxylase (NADH); 5-demethoxyubiquinone hydroxylase, mitochondrial; DMQ hydroxylase; NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial isoform 1 precursor; NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial; coenzyme Q biosynthesis protein 7 homolog; timing protein clk-1 homolog; ubiquinone biosynthesis monooxygenase COQ7; ubiquinone biosynthesis protein COQ7 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:504771)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydroxylation of the 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone at the C6 position and participates in the biosynthesis of ubiquinone. Catalyzes the reaction through a substrate-mediated reduction pathway, whereby NADH shuttles electrons to 5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzoquinone, which then transfers the electrons to the two Fe(3+) centers. The binding of 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone (DMQn) mediates reduction of the diiron center by nicotinamide adenine dinucleotide (NADH) and initiates oxygen activation for subsequent DMQ hydroxylation. The physiological substrates are 5-methoxy-2-methyl-3-(all-trans-nonaprenyl)benzoquinone (DMQ(9)) and 5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzoquinone (DMQ(10)), however in vitro the enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency (By similarity). Also has a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner (By similarity). Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis (By similarity)., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.13.253", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.253", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0160224 3-demethoxyubiquinone 3-hydroxylase (NADH) activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005634 nucleus;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:2000377 regulation of reactive oxygen species metabolic process;GO:0006744 ubiquinone biosynthetic process;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBW2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBW7-1", "uniprot_id": [ { "id": "SNX2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBW7", "type": "external" } ], "mass": 58454.0, "length": 519, "protein_name": "Sorting nexin-2", "gene_name": "SNX2", "organism": "Bovine", "refseq_name": "sorting nexin-2", "refseq_ac": [ { "id": "NP_001033608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033608", "type": "external" } ], "gene_names_uniprotkb": "SNX2", "gene_names_refseq": "SNX2", "protein_names_uniprotkb": "Sorting nexin-2", "protein_names_refseq": "sorting nexin-2", "tax_id": 9913, "disease": "", "pathway": " (bta:509769)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0031901 early endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0072673 lamellipodium morphogenesis;GO:0042147 retrograde transport, endosome to Golgi;GO:0034498 early endosome to Golgi transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBW7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2V8Y7-1", "uniprot_id": [ { "id": "NCS1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2V8Y7", "type": "external" } ], "mass": 21833.0, "length": 190, "protein_name": "Neuronal calcium sensor 1", "gene_name": "NCS1", "organism": "Bovine", "refseq_name": "neuronal calcium sensor 1", "refseq_ac": [ { "id": "NP_001035637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035637", "type": "external" } ], "gene_names_uniprotkb": "NCS1; FREQ", "gene_names_refseq": "FREQ; NCS-1; NCS1", "protein_names_uniprotkb": "Neuronal calcium sensor 1; Frequenin homolog; NCS-1", "protein_names_refseq": "frequenin homolog; frequenin-like protein; neuronal calcium sensor 1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "11526106;15576365;16733800;25714968", "class_list": "", "function": "C-terminal segment of NCS1 regulates reuptake of myristoyl group under Ca(2+)-free conditions and participates in organization of the target-binding pocket of the protein. We show putative role of NCS1 in photoreceptors as a modulator of GRK activity, [RefSeq, PubMed]; Frequenin (BovFrq) native to the bovine hippocampus has been purified, sequenced for its 9 internal fragments, cloned, and studied., [RefSeq, PubMed]; NCS-1-ARF1 interaction provides evidence for functional cross-talk between Ca(2+)-dependent and ARF-dependent pathways in TGN to plasma membrane traffic, [RefSeq, PubMed]; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005245 voltage-gated calcium channel activity;GO:0008048 calcium sensitive guanylate cyclase activator activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0009966 regulation of signal transduction;GO:0010975 regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q2V8Y7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2VWH6-1", "uniprot_id": [ { "id": "FEZF2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2VWH6", "type": "external" } ], "mass": 48842.0, "length": 458, "protein_name": "Fez family zinc finger protein 2", "gene_name": "FEZF2", "organism": "Bovine", "refseq_name": "fez family zinc finger protein 2", "refseq_ac": [ { "id": "NP_001033287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033287", "type": "external" } ], "gene_names_uniprotkb": "FEZF2; FEZL; ZNF312", "gene_names_refseq": "FEZF2; ZNF312", "protein_names_uniprotkb": "Fez family zinc finger protein 2; Forebrain embryonic zinc finger-like protein 2; Zinc finger protein 312; Zinc finger protein Fez-like", "protein_names_refseq": "fez family zinc finger protein 2; forebrain embryonic zinc finger-like protein 2; zinc finger protein 312", "tax_id": 9913, "disease": "", "pathway": " (bta:613683)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16611727;21427001", "class_list": "", "function": "Enhanced clinical mastitis resistance in Holsteins with a FEZL p.Gly105(12_13) polymorphism., [RefSeq, PubMed]; Transcription repressor. Binds to 5'GCAG-3' core sequence. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons (By similarity). May be responsible for mastitis resistance and innate immunity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2VWH7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003682 chromatin binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2VWH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32KM1-1", "uniprot_id": [ { "id": "TBG2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32KM1", "type": "external" } ], "mass": 51065.0, "length": 451, "protein_name": "Tubulin gamma-2 chain", "gene_name": "TUBG2", "organism": "Bovine", "refseq_name": "tubulin gamma-2 chain", "refseq_ac": [ { "id": "NP_001032704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032704", "type": "external" } ], "gene_names_uniprotkb": "TUBG2", "gene_names_refseq": "TUBG2", "protein_names_uniprotkb": "Tubulin gamma-2 chain; Gamma-2-tubulin", "protein_names_refseq": "gamma-2-tubulin; tubulin gamma-2 chain", "tax_id": 9913, "disease": "", "pathway": " (bta:540216); (R-BTA-380270); (R-BTA-380320)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (By similarity). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (By similarity). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0140490 microtubule nucleator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0034451 centriolar satellite", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007020 microtubule nucleation;GO:0007052 mitotic spindle organization;GO:0000070 mitotic sister chromatid segregation;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32KM1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32KR6-1", "uniprot_id": [ { "id": "FDFT_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32KR6", "type": "external" } ], "mass": 48304.0, "length": 417, "protein_name": "Squalene synthase", "gene_name": "FDFT1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FDFT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Squalene synthase; 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; SQS; SS", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.21", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051996 squalene synthase [NAD(P)H] activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0008299 isoprenoid biosynthetic process;GO:0045338 farnesyl diphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32KR6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32L23-1", "uniprot_id": [ { "id": "LIMK2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32L23", "type": "external" } ], "mass": 72165.0, "length": 638, "protein_name": "LIM domain kinase 2", "gene_name": "LIMK2", "organism": "Bovine", "refseq_name": "LIM domain kinase 2", "refseq_ac": [ { "id": "NP_001033187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033187", "type": "external" } ], "gene_names_uniprotkb": "LIMK2", "gene_names_refseq": "LIMK2", "protein_names_uniprotkb": "LIM domain kinase 2; 2.7.11.1; LIMK-2", "protein_names_refseq": "LIM domain kinase 2; LIMK-2", "tax_id": 9913, "disease": "", "pathway": " (bta:513539)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0072686 mitotic spindle", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0006468 protein phosphorylation;GO:0030036 actin cytoskeleton organization;GO:1900182 positive regulation of protein localization to nucleus;GO:0051650 establishment of vesicle localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32L23-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32L31-1", "uniprot_id": [ { "id": "HMGB3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32L31", "type": "external" } ], "mass": 22896.0, "length": 200, "protein_name": "High mobility group protein B3", "gene_name": "HMGB3", "organism": "Bovine", "refseq_name": "high mobility group protein B3 isoform 1", "refseq_ac": [ { "id": "NP_001069753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069753", "type": "external" } ], "gene_names_uniprotkb": "HMGB3", "gene_names_refseq": "HMGB3", "protein_names_uniprotkb": "High mobility group protein B3", "protein_names_refseq": "high mobility group protein B3 isoform 1; high mobility group protein B3", "tax_id": 9913, "disease": "", "pathway": " (bta:613729)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23206268", "class_list": "", "function": "HMGB3 expression is under complex transcriptional and post-transcriptional control by alternate promoter usage, alternative splicing mechanism and microRNAs in dairy cattle., [RefSeq, PubMed]; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003690 double-stranded DNA binding;GO:0000400 four-way junction DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006310 DNA recombination;GO:0006351 DNA-templated transcription;GO:0045087 innate immune response;GO:0032392 DNA geometric change", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32L31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32L48-1", "uniprot_id": [ { "id": "H2B1N_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32L48", "type": "external" } ], "mass": 13923.0, "length": 126, "protein_name": "Histone H2B type 1-N", "gene_name": "H2BC15", "organism": "Bovine", "refseq_name": "histone H2B type 1-N", "refseq_ac": [ { "id": "NP_001075211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075211", "type": "external" } ], "gene_names_uniprotkb": "H2BC15", "gene_names_refseq": "H2BC15; HIST1H2BB; HIST1H2BN", "protein_names_uniprotkb": "Histone H2B type 1-N", "protein_names_refseq": "histone H2B type 1-N; histone cluster 1, H2bn", "tax_id": 9913, "disease": "", "pathway": " (bta:614958)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2713375", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32L48-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32L57-1", "uniprot_id": [ { "id": "TUSC3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32L57", "type": "external" } ], "mass": 39536.0, "length": 347, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3", "gene_name": "TUSC3", "organism": "Bovine", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3 precursor", "refseq_ac": [ { "id": "NP_001074383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074383", "type": "external" } ], "gene_names_uniprotkb": "TUSC3", "gene_names_refseq": "TUSC3", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3; Magnesium uptake/transporter TUSC3; Oligosaccharyl transferase subunit TUSC3; Tumor suppressor candidate 3", "protein_names_refseq": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3 precursor; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3; magnesium uptake/transporter TUSC3; oligosaccharyl transferase subunit TUSC3", "tax_id": 9913, "disease": "", "pathway": " (bta:615007)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Also has oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Could indirectly play a role in Mg(2+) transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity;GO:0062062 oligosaccharyltransferase complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0015693 magnesium ion transport;GO:1903830 magnesium ion transmembrane transport;GO:0050890 cognition;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32L57-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LC4-1", "uniprot_id": [ { "id": "EMC5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LC4", "type": "external" } ], "mass": 18950.0, "length": 165, "protein_name": "ER membrane protein complex subunit 5", "gene_name": "MMGT1", "organism": "Bovine", "refseq_name": "ER membrane protein complex subunit 5 precursor", "refseq_ac": [ { "id": "NP_001073098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073098", "type": "external" } ], "gene_names_uniprotkb": "MMGT1; EMC5; TMEM32", "gene_names_refseq": "MMGT1; TMEM32", "protein_names_uniprotkb": "ER membrane protein complex subunit 5; Membrane magnesium transporter 1; Transmembrane protein 32", "protein_names_refseq": "ER membrane protein complex subunit 5 precursor; ER membrane protein complex subunit 5; transmembrane protein 32", "tax_id": 9913, "disease": "", "pathway": " (bta:617557)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. May be involved in Mg(2+) transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0072546 EMC complex;GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32LC4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LE5-1", "uniprot_id": [ { "id": "ASGL1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LE5", "type": "external" } ], "mass": 32050.0, "length": 308, "protein_name": "Isoaspartyl peptidase/L-asparaginase", "gene_name": "ASRGL1", "organism": "Bovine", "refseq_name": "isoaspartyl peptidase/L-asparaginase", "refseq_ac": [ { "id": "NP_001070503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070503", "type": "external" } ], "gene_names_uniprotkb": "ASRGL1", "gene_names_refseq": "ASRGL1", "protein_names_uniprotkb": "Isoaspartyl peptidase/L-asparaginase; 3.4.19.5; 3.5.1.1; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase", "protein_names_refseq": "L-asparaginase; L-asparagine amidohydrolase; asparaginase like 1; asparaginase-like protein 1; beta-aspartyl-peptidase; isoaspartyl dipeptidase; isoaspartyl peptidase/L-asparaginase", "tax_id": 9913, "disease": "", "pathway": " (bta:767970); (R-BTA-8964208)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.5", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" } ], "go_molecular_function": "GO:0004067 asparaginase activity;GO:0008798 beta-aspartyl-peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0006508 proteolysis;GO:0033345 L-asparagine catabolic process via L-aspartate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32LE5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LL2-1", "uniprot_id": [ { "id": "STML2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LL2", "type": "external" } ], "mass": 38733.0, "length": 356, "protein_name": "Stomatin-like protein 2, mitochondrial", "gene_name": "STOML2", "organism": "Bovine", "refseq_name": "stomatin-like protein 2, mitochondrial", "refseq_ac": [ { "id": "NP_001033157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033157", "type": "external" } ], "gene_names_uniprotkb": "STOML2", "gene_names_refseq": "STOML2", "protein_names_uniprotkb": "Stomatin-like protein 2, mitochondrial; SLP-2", "protein_names_refseq": "SLP-2; stomatin (EPB72)-like 2; stomatin-like protein 2, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:510324)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042608 T cell receptor binding;GO:1901612 cardiolipin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0035710 CD4-positive, alpha-beta T cell activation;GO:0010876 lipid localization;GO:1990046 stress-induced mitochondrial fusion;GO:0051259 protein complex oligomerization;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32LL2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LN5-1", "uniprot_id": [ { "id": "RN138_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LN5", "type": "external" } ], "mass": 28157.0, "length": 245, "protein_name": "E3 ubiquitin-protein ligase RNF138", "gene_name": "RNF138", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase RNF138", "refseq_ac": [ { "id": "NP_001033263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033263", "type": "external" } ], "gene_names_uniprotkb": "RNF138", "gene_names_refseq": "RNF138", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF138; 2.3.2.27; RING finger protein 138; RING-type E3 ubiquitin transferase RNF138", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF138; RING-type E3 ubiquitin transferase RNF138", "tax_id": 9913, "disease": "", "pathway": " (bta:538445); (R-BTA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0035861 site of double-strand break", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0016567 protein ubiquitination;GO:0000724 double-strand break repair via homologous recombination;GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32LN5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32P73-1", "uniprot_id": [ { "id": "RPB9_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32P73", "type": "external" } ], "mass": 14489.0, "length": 125, "protein_name": "DNA-directed RNA polymerase II subunit RPB9", "gene_name": "POLR2I", "organism": "Bovine", "refseq_name": "DNA-directed RNA polymerase II subunit RPB9", "refseq_ac": [ { "id": "NP_001069797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069797", "type": "external" } ], "gene_names_uniprotkb": "POLR2I", "gene_names_refseq": "POLR2I; RPB14.5; RPB9", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB9; DNA-directed RNA polymerase II subunit I; RNA polymerase II subunit B9", "protein_names_refseq": "DNA-directed RNA polymerase II 14.5 kDa polypeptide; DNA-directed RNA polymerase II subunit I; DNA-directed RNA polymerase II subunit RPB9; RNA polymerase II subunit B9; polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:614472)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16769904;26789250;28892040", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2I/RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006283 transcription-coupled nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q32P73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32P78-1", "uniprot_id": [ { "id": "RPAB5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32P78", "type": "external" } ], "mass": 7645.0, "length": 67, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC5", "gene_name": "POLR2L", "organism": "Bovine", "refseq_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC5", "refseq_ac": [ { "id": "NP_001107198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107198", "type": "external" } ], "gene_names_uniprotkb": "POLR2L", "gene_names_refseq": "POLR2L", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-directed RNA polymerase III subunit L; RNA polymerases I, II, and III subunit ABC5", "protein_names_refseq": "DNA-directed RNA polymerase III subunit L; DNA-directed RNA polymerases I, II, and III subunit RPABC5; RNA polymerase II subunit L; RNA polymerases I, II, and III subunit ABC5; RPB10; polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:617375); (R-BTA-112382); (R-BTA-113418); (R-BTA-5250924); (R-BTA-5578749); (R-BTA-674695); (R-BTA-6781823); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-6796648); (R-BTA-6803529); (R-BTA-6807505); (R-BTA-72086); (R-BTA-72163); (R-BTA-72165); (R-BTA-72203); (R-BTA-73762); (R-BTA-73772); (R-BTA-73776); (R-BTA-73779); (R-BTA-73863); (R-BTA-75953); (R-BTA-75955); (R-BTA-76042); (R-BTA-76061); (R-BTA-76066); (R-BTA-76071); (R-BTA-77075); (R-BTA-9018519); (R-BTA-9770562)", "pathway_count": 30, "publication_count": 3, "publication_id_list": "16769904;26789250;28892040", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q32P78-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PA4-1", "uniprot_id": [ { "id": "PHP14_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32PA4", "type": "external" } ], "mass": 13931.0, "length": 125, "protein_name": "14 kDa phosphohistidine phosphatase", "gene_name": "PHPT1", "organism": "Bovine", "refseq_name": "14 kDa phosphohistidine phosphatase", "refseq_ac": [ { "id": "NP_001069984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069984", "type": "external" } ], "gene_names_uniprotkb": "PHPT1; PHP14", "gene_names_refseq": "PHP14; PHPT1; PHP", "protein_names_uniprotkb": "14 kDa phosphohistidine phosphatase; 3.9.1.3; PHPT1; PHP; Phosphohistidine phosphatase 1; Protein histidine phosphatase", "protein_names_refseq": "14 kDa phosphohistidine phosphatase; 14kDa phosphohistidine phosphatase; protein histidine phosphatase", "tax_id": 9913, "disease": "", "pathway": " (bta:618691)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exhibits phosphohistidine phosphatase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.9.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.3", "type": "external" } ], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0051015 actin filament binding;GO:0044325 transmembrane transporter binding;GO:0019855 calcium channel inhibitor activity;GO:0101006 protein histidine phosphatase activity", "go_cellular_component": "GO:0061851 leading edge of lamellipodium;GO:0005829 cytosol", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:2000147 positive regulation of cell motility;GO:0097581 lamellipodium organization;GO:0050860 negative regulation of T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32PA4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PE0-1", "uniprot_id": [ { "id": "RPAB2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32PE0", "type": "external" } ], "mass": 14448.0, "length": 127, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC2", "gene_name": "POLR2F", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "POLR2F", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-directed RNA polymerase II subunit F; RNA polymerases I, II, and III subunit ABC2; RPB6 homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "16769904;26789250;28892040", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPABC2 is part of the clamp element and together with parts of POLR2A/RPB1 and POLR2B/RPB2 forms a pocket to which the POLR2D/RPB4-POLR2G/RPB7 subcomplex binds., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q32PE0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PG7-1", "uniprot_id": [ { "id": "TM175_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32PG7", "type": "external" } ], "mass": 51966.0, "length": 479, "protein_name": "Endosomal/lysosomal proton channel TMEM175", "gene_name": "TMEM175", "organism": "Bovine", "refseq_name": "endosomal/lysosomal proton channel TMEM175", "refseq_ac": [ { "id": "NP_001069081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069081", "type": "external" } ], "gene_names_uniprotkb": "TMEM175", "gene_names_refseq": "TMEM175", "protein_names_uniprotkb": "Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175", "protein_names_refseq": "endosomal/lysomomal potassium channel TMEM175; endosomal/lysosomal potassium channel TMEM175; endosomal/lysosomal proton channel TMEM175", "tax_id": 9913, "disease": "", "pathway": " (bta:513317)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH. Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis. Regulation of lumenal pH stability is required for autophagosome-lysosome fusion. Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes. Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors. The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation. The lysoK(GF) complex is required to protect neurons against stress-induced damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1ME05", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022841 potassium ion leak channel activity;GO:0005267 potassium channel activity;GO:0050544 arachidonate binding;GO:0015252 proton channel activity", "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0070050 neuron cellular homeostasis;GO:0035752 lysosomal lumen pH elevation;GO:0090385 phagosome-lysosome fusion;GO:0071805 potassium ion transmembrane transport;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32PG7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PH7-1", "uniprot_id": [ { "id": "SUV92_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32PH7", "type": "external" } ], "mass": 46551.0, "length": 410, "protein_name": "Histone-lysine N-methyltransferase SUV39H2", "gene_name": "SUV39H2", "organism": "Bovine", "refseq_name": "histone-lysine N-methyltransferase SUV39H2", "refseq_ac": [ { "id": "NP_001032556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032556", "type": "external" } ], "gene_names_uniprotkb": "SUV39H2", "gene_names_refseq": "SUV39H2", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SUV39H2; 2.1.1.-; Su(var)3-9 homolog 2; Suppressor of variegation 3-9 homolog 2", "protein_names_refseq": "histone-lysine N-methyltransferase SUV39H2; su(var)3-9 homolog 2; suppressor of variegation 3-9 homolog 2", "tax_id": 9913, "disease": "", "pathway": " (bta:536936); (R-BTA-3214841)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H2 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length (By similarity). May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0046974 histone H3K9 methyltransferase activity;GO:0140947 histone H3K9me2 methyltransferase activity;GO:0140258 histone H3K14ub reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005721 pericentric heterochromatin;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0031508 pericentric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32PH7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PI8-1", "uniprot_id": [ { "id": "RT27_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32PI8", "type": "external" } ], "mass": 47955.0, "length": 415, "protein_name": "Small ribosomal subunit protein mS27", "gene_name": "MRPS27", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein mS27", "refseq_ac": [ { "id": "NP_001033197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033197", "type": "external" } ], "gene_names_uniprotkb": "MRPS27", "gene_names_refseq": "MRPS27", "protein_names_uniprotkb": "Small ribosomal subunit protein mS27; 28S ribosomal protein S27, mitochondrial; MRP-S27; Mitochondrial ribosomal protein S27; S27mt", "protein_names_refseq": "28S ribosomal protein S27, mitochondrial; MRP-S27; S27mt; small ribosomal subunit protein mS27", "tax_id": 9913, "disease": "", "pathway": " (bta:514740)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11344316", "class_list": "", "function": "RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Overexpressed in hepatocellular carcinoma tissues compared with adjacent non-tumoral liver tissues., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P82677", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006417 regulation of translation;GO:0008283 cell population proliferation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32PI8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PJ2-1", "uniprot_id": [ { "id": "APOA4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32PJ2", "type": "external" } ], "mass": 43018.0, "length": 380, "protein_name": "Apolipoprotein A-IV", "gene_name": "APOA4", "organism": "Bovine", "refseq_name": "apolipoprotein A-IV precursor", "refseq_ac": [ { "id": "NP_001032557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032557", "type": "external" } ], "gene_names_uniprotkb": "APOA4", "gene_names_refseq": "APOA4", "protein_names_uniprotkb": "Apolipoprotein A-IV; Apo-AIV; ApoA-IV; Apolipoprotein A4", "protein_names_refseq": "apo-AIV; apoA-IV; apolipoprotein A-IV precursor; apolipoprotein A-IV", "tax_id": 9913, "disease": "", "pathway": " (bta:537301)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle;GO:0042627 chylomicron;GO:0034362 low-density lipoprotein particle;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0033700 phospholipid efflux;GO:0042157 lipoprotein metabolic process;GO:0033344 cholesterol efflux;GO:0006950 response to stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32PJ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32S24-1", "uniprot_id": [ { "id": "COBA2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32S24", "type": "external" } ], "mass": 172238.0, "length": 1736, "protein_name": "Collagen alpha-2(XI) chain", "gene_name": "COL11A2", "organism": "Bovine", "refseq_name": "collagen alpha-2(XI) chain precursor", "refseq_ac": [ { "id": "NP_001039664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039664", "type": "external" } ], "gene_names_uniprotkb": "COL11A2", "gene_names_refseq": "COL11A2", "protein_names_uniprotkb": "Collagen alpha-2(XI) chain", "protein_names_refseq": "collagen alpha-2(XI) chain precursor; collagen alpha-2(XI) chain; collagen, type XI, alpha 2", "tax_id": 9913, "disease": "", "pathway": " (bta:515435)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16573526", "class_list": "", "function": "May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 2, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0007605 sensory perception of sound;GO:0048705 skeletal system morphogenesis;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32S24-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7L6-1", "uniprot_id": [ { "id": "SRSF6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3B7L6", "type": "external" } ], "mass": 39647.0, "length": 345, "protein_name": "Serine/arginine-rich splicing factor 6", "gene_name": "SRSF6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SRSF6; SFRS6", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 6; Splicing factor, arginine/serine-rich 6", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:507828)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0045617 negative regulation of keratinocyte differentiation;GO:0061041 regulation of wound healing;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0006376 mRNA splice site recognition;GO:0010837 regulation of keratinocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B7L6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7L8-1", "uniprot_id": [ { "id": "RBM22_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3B7L8", "type": "external" } ], "mass": 46930.0, "length": 420, "protein_name": "Pre-mRNA-splicing factor RBM22", "gene_name": "RBM22", "organism": "Bovine", "refseq_name": "pre-mRNA-splicing factor RBM22", "refseq_ac": [ { "id": "NP_001032907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032907", "type": "external" } ], "gene_names_uniprotkb": "RBM22", "gene_names_refseq": "RBM22", "protein_names_uniprotkb": "Pre-mRNA-splicing factor RBM22; RNA-binding motif protein 22", "protein_names_refseq": "pre-mRNA-splicing factor RBM22", "tax_id": 9913, "disease": "", "pathway": " (bta:512330)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0008270 zinc ion binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0071007 U2-type catalytic step 2 spliceosome;GO:0000974 Prp19 complex", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0033120 positive regulation of RNA splicing;GO:0046827 positive regulation of protein export from nucleus;GO:0071466 cellular response to xenobiotic stimulus;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B7L8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7M2-1", "uniprot_id": [ { "id": "GLO2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3B7M2", "type": "external" } ], "mass": 34089.0, "length": 308, "protein_name": "Hydroxyacylglutathione hydrolase, mitochondrial", "gene_name": "HAGH", "organism": "Bovine", "refseq_name": "hydroxyacylglutathione hydrolase, mitochondrial", "refseq_ac": [ { "id": "NP_001030351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030351", "type": "external" } ], "gene_names_uniprotkb": "HAGH", "gene_names_refseq": "HAGH", "protein_names_uniprotkb": "Hydroxyacylglutathione hydrolase, mitochondrial; 3.1.2.6; Glx II; Glyoxalase II", "protein_names_refseq": "glx II; glyoxalase II; hydroxyacylglutathione hydrolase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:509274); (R-BTA-70268)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.6", "type": "external" } ], "go_molecular_function": "GO:0004416 hydroxyacylglutathione hydrolase activity;GO:0046872 metal ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B7M2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7N1-1", "uniprot_id": [ { "id": "CHD1L_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3B7N1", "type": "external" } ], "mass": 101424.0, "length": 897, "protein_name": "ATP-dependent chromatin remodeler CHD1L", "gene_name": "CHD1L", "organism": "Bovine", "refseq_name": "ATP-dependent chromatin remodeler CHD1L", "refseq_ac": [ { "id": "NP_001032909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032909", "type": "external" } ], "gene_names_uniprotkb": "CHD1L", "gene_names_refseq": "CHD1L", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD1L; 3.6.4.-; Chromo domain-containing protein 1-like", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD1L; chromo domain-containing protein 1-like", "tax_id": 9913, "disease": "", "pathway": " (bta:524787)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MFS2", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000166 nucleotide binding;GO:0016887 ATP hydrolysis activity;GO:0031491 nucleosome binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0005694 chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B7N1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHI4-1", "uniprot_id": [ { "id": "PHAX_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHI4", "type": "external" } ], "mass": 44578.0, "length": 394, "protein_name": "Phosphorylated adapter RNA export protein", "gene_name": "PHAX", "organism": "Bovine", "refseq_name": "phosphorylated adapter RNA export protein", "refseq_ac": [ { "id": "NP_001160034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160034", "type": "external" } ], "gene_names_uniprotkb": "PHAX; RNUXA", "gene_names_refseq": "PHAX; RNUXA", "protein_names_uniprotkb": "Phosphorylated adapter RNA export protein; RNA U small nuclear RNA export adapter protein", "protein_names_refseq": "RNA U small nuclear RNA export adapter protein; RNA U, small nuclear RNA export adaptor (phosphorylation regulated); phosphorylated adapter RNA export protein", "tax_id": 9913, "disease": "", "pathway": " (bta:507478); (R-BTA-6807505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0140262 mRNA cap binding complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0015030 Cajal body;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0015031 protein transport;GO:0006408 snRNA export from nucleus;GO:0043489 RNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHI4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHL3-1", "uniprot_id": [ { "id": "RBBP4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHL3", "type": "external" } ], "mass": 47656.0, "length": 425, "protein_name": "Histone-binding protein RBBP4", "gene_name": "RBBP4", "organism": "Bovine", "refseq_name": "histone-binding protein RBBP4", "refseq_ac": [ { "id": "NP_001070481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070481", "type": "external" } ], "gene_names_uniprotkb": "RBBP4", "gene_names_refseq": "RBBP4", "protein_names_uniprotkb": "Histone-binding protein RBBP4; CAF-1 subunit C; Chromatin assembly factor 1 subunit C; Nucleosome-remodeling factor subunit RBAP48; RBBP-4; Retinoblastoma-binding protein 4", "protein_names_refseq": "CAF-1 subunit C; RBBP-4; chromatin assembly factor 1 subunit C; histone-binding protein RBBP4; nucleosome-remodeling factor subunit RBAP48; retinoblastoma binding protein 4", "tax_id": 9913, "disease": "", "pathway": " (bta:767940); (R-BTA-1538133); (R-BTA-212300); (R-BTA-2559580); (R-BTA-3214815); (R-BTA-3214841); (R-BTA-606279); (R-BTA-6804758); (R-BTA-73762); (R-BTA-8943724); (R-BTA-8953750); (R-BTA-9764725); (R-BTA-9909649); (R-BTA-9937850); (R-BTA-9940951)", "pathway_count": 15, "publication_count": 2, "publication_id_list": "16305752;8602529", "class_list": "", "function": "Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (By similarity). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (By similarity). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (By similarity). Component of the PRC2 complex, which promotes repression of homeotic genes during development (By similarity). Component of the NURF (nucleosome remodeling factor) complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D9B1", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex;GO:0033186 CAF-1 complex;GO:0000781 chromosome, telomeric region;GO:0016581 NuRD complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3MHL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHL9-1", "uniprot_id": [ { "id": "MSRB1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHL9", "type": "external" } ], "mass": 12833.0, "length": 116, "protein_name": "Methionine-R-sulfoxide reductase B1", "gene_name": "MSRB1", "organism": "Bovine", "refseq_name": "methionine-R-sulfoxide reductase B1", "refseq_ac": [ { "id": "NP_001029982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029982", "type": "external" } ], "gene_names_uniprotkb": "MSRB1; SEPX1", "gene_names_refseq": "MSRB1; SEPX1", "protein_names_uniprotkb": "Methionine-R-sulfoxide reductase B1; 1.8.4.12; 1.8.4.14; MsrB1; SelX; Selenoprotein X", "protein_names_refseq": "methionine-R-sulfoxide reductase B1; selX; selenoprotein X, 1", "tax_id": 9913, "disease": "", "pathway": " (bta:618441)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages., [UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Oct 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.12", "type": "external" }, { "id": "1.8.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.14", "type": "external" } ], "go_molecular_function": "GO:0033743 peptide-methionine (R)-S-oxide reductase activity;GO:0033745 L-methionine-(R)-S-oxide reductase activity;GO:0003779 actin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0045087 innate immune response;GO:0030041 actin filament polymerization;GO:0030091 protein repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHL9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHM6-1", "uniprot_id": [ { "id": "CTNA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHM6", "type": "external" } ], "mass": 100133.0, "length": 906, "protein_name": "Catenin alpha-1", "gene_name": "CTNNA1", "organism": "Bovine", "refseq_name": "catenin alpha-1", "refseq_ac": [ { "id": "NP_001030443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030443", "type": "external" } ], "gene_names_uniprotkb": "CTNNA1", "gene_names_refseq": "CTNNA1", "protein_names_uniprotkb": "Catenin alpha-1", "protein_names_refseq": "catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha-1", "tax_id": 9913, "disease": "", "pathway": " (bta:526848)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005198 structural molecule activity;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:1900181 negative regulation of protein localization to nucleus;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHM6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHN0-1", "uniprot_id": [ { "id": "PSB6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHN0", "type": "external" } ], "mass": 25542.0, "length": 239, "protein_name": "Proteasome subunit beta type-6", "gene_name": "PSMB6", "organism": "Bovine", "refseq_name": "proteasome subunit beta type-6", "refseq_ac": [ { "id": "NP_001029541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029541", "type": "external" } ], "gene_names_uniprotkb": "PSMB6", "gene_names_refseq": "PSMB6", "protein_names_uniprotkb": "Proteasome subunit beta type-6; 3.4.25.1", "protein_names_refseq": "proteasome (prosome, macropain) subunit, beta type, 6; proteasome subunit beta 6; proteasome subunit beta type-6", "tax_id": 9913, "disease": "", "pathway": " (bta:510069); (R-BTA-1169091); (R-BTA-1234176); (R-BTA-1236974); (R-BTA-1236978); (R-BTA-174084); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-187577); (R-BTA-195253); (R-BTA-202424); (R-BTA-2467813); (R-BTA-2871837); (R-BTA-349425); (R-BTA-350562); (R-BTA-382556); (R-BTA-450408); (R-BTA-4608870); (R-BTA-4641257); (R-BTA-4641258); (R-BTA-5358346); (R-BTA-5607761); (R-BTA-5607764); (R-BTA-5610780); (R-BTA-5610785); (R-BTA-5632684); (R-BTA-5668541); (R-BTA-5676590); (R-BTA-5687128); (R-BTA-5689603); (R-BTA-5689880); (R-BTA-68867); (R-BTA-68949); (R-BTA-69017); (R-BTA-69481); (R-BTA-69601); (R-BTA-75815); (R-BTA-8852276); (R-BTA-8854050); (R-BTA-8939236); (R-BTA-8939902); (R-BTA-8941858); (R-BTA-8948751); (R-BTA-8951664); (R-BTA-9020702); (R-BTA-9755511); (R-BTA-9762114); (R-BTA-9766229); (R-BTA-983168); (R-BTA-9907900); (R-BTA-9912633); (R-BTA-9929356); (R-BTA-9929491); (R-BTA-9931269); (R-BTA-9932298); (R-BTA-9954709)", "pathway_count": 57, "publication_count": 1, "publication_id_list": "12015144", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "4.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.17", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005839 proteasome core complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3MHN0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHN7-1", "uniprot_id": [ { "id": "NEIL3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHN7", "type": "external" } ], "mass": 67384.0, "length": 606, "protein_name": "Endonuclease 8-like 3", "gene_name": "NEIL3", "organism": "Bovine", "refseq_name": "endonuclease 8-like 3", "refseq_ac": [ { "id": "NP_001029662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029662", "type": "external" } ], "gene_names_uniprotkb": "NEIL3", "gene_names_refseq": "NEIL3", "protein_names_uniprotkb": "Endonuclease 8-like 3; 3.2.2.-; 4.2.99.18; DNA glycosylase/AP lyase Neil3; Endonuclease VIII-like 3; Nei-like protein 3", "protein_names_refseq": "DNA glycosylase/AP lyase Neil3; endonuclease 8-like 3; endonuclease VIII-like 3; nei endonuclease VIII-like 3; nei-like protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:515343); (R-BTA-110330); (R-BTA-110331)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (By similarity). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1N383", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0019104 DNA N-glycosylase activity;GO:0003690 double-stranded DNA binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006284 base-excision repair;GO:0036297 interstrand cross-link repair;GO:0000012 single strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3MHN7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHP5-1", "uniprot_id": [ { "id": "DRG1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHP5", "type": "external" } ], "mass": 40542.0, "length": 367, "protein_name": "Developmentally-regulated GTP-binding protein 1", "gene_name": "DRG1", "organism": "Bovine", "refseq_name": "developmentally-regulated GTP-binding protein 1", "refseq_ac": [ { "id": "NP_001029863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029863", "type": "external" } ], "gene_names_uniprotkb": "DRG1", "gene_names_refseq": "DRG1; NEDD-3", "protein_names_uniprotkb": "Developmentally-regulated GTP-binding protein 1; 3.6.5.-; DRG-1; NEDD-3; Neural precursor cell expressed developmentally down-regulated protein 3; TRAFAC GTPase DRG1; Translation factor GTPase DRG1", "protein_names_refseq": "DRG-1; TRAFAC GTPase DRG1; developmentally-regulated GTP-binding protein 1; neural precursor cell expressed developmentally down-regulated protein 3; translation factor GTPase DRG1", "tax_id": 9913, "disease": "", "pathway": " (bta:540161); (R-BTA-9629569)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "1.14.11.63", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.63", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0031116 positive regulation of microtubule polymerization;GO:1901673 regulation of mitotic spindle assembly;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHP5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHQ0-1", "uniprot_id": [ { "id": "USH1C_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHQ0", "type": "external" } ], "mass": 62065.0, "length": 551, "protein_name": "Harmonin", "gene_name": "USH1C", "organism": "Bovine", "refseq_name": "harmonin", "refseq_ac": [ { "id": "NP_001030459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030459", "type": "external" } ], "gene_names_uniprotkb": "USH1C", "gene_names_refseq": "USH1C", "protein_names_uniprotkb": "Harmonin; Usher syndrome type-1C protein homolog", "protein_names_refseq": "Usher syndrome 1C (autosomal recessive, severe); harmonin; usher syndrome type-1C protein homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:530709)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005929 cilium", "go_biological_process": "GO:0050885 neuromuscular process controlling balance;GO:0007605 sensory perception of sound;GO:1904106 protein localization to microvillus;GO:1904970 brush border assembly;GO:0032532 regulation of microvillus length", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHQ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHR0-1", "uniprot_id": [ { "id": "LYPA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHR0", "type": "external" } ], "mass": 24596.0, "length": 230, "protein_name": "Acyl-protein thioesterase 1", "gene_name": "LYPLA1", "organism": "Bovine", "refseq_name": "acyl-protein thioesterase 1", "refseq_ac": [ { "id": "NP_001029860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029860", "type": "external" } ], "gene_names_uniprotkb": "LYPLA1", "gene_names_refseq": "LYPLA1", "protein_names_uniprotkb": "Acyl-protein thioesterase 1; 3.1.2.-; 3.1.2.22; APT-1; LPL-I; LysoPLA I; Lysophospholipase 1; Lysophospholipase I; Palmitoyl-protein hydrolase", "protein_names_refseq": "APT-1; LPL-I; acyl-protein thioesterase 1; lysoPLA I; lysophospholipase I; palmitoyl-protein hydrolase", "tax_id": 9913, "disease": "", "pathway": " (bta:539992)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC) (By similarity). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0042997 negative regulation of Golgi to plasma membrane protein transport;GO:0002084 protein depalmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHR0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHR2-1", "uniprot_id": [ { "id": "DCK_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHR2", "type": "external" } ], "mass": 30329.0, "length": 260, "protein_name": "Deoxycytidine kinase", "gene_name": "DCK", "organism": "Bovine", "refseq_name": "deoxycytidine kinase", "refseq_ac": [ { "id": "NP_001029745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029745", "type": "external" } ], "gene_names_uniprotkb": "DCK", "gene_names_refseq": "DCK", "protein_names_uniprotkb": "Deoxycytidine kinase; 2.7.1.113; 2.7.1.74; 2.7.1.76; Deoxyadenosine kinase; Deoxyguanosine kinase; dCK", "protein_names_refseq": "deoxyadenosine kinase; deoxycytidine kinase; deoxyguanosine kinase", "tax_id": 9913, "disease": "", "pathway": " (bta:530642); (R-BTA-73614); (R-BTA-74217)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.113", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.113", "type": "external" }, { "id": "2.7.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.76", "type": "external" }, { "id": "2.7.1.74", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.74", "type": "external" } ], "go_molecular_function": "GO:0004138 deoxyguanosine kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0004137 deoxycytidine kinase activity;GO:0004136 deoxyadenosine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0032261 purine nucleotide salvage;GO:0006220 pyrimidine nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHR2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHX5-1", "uniprot_id": [ { "id": "SUCB2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHX5", "type": "external" } ], "mass": 46691.0, "length": 432, "protein_name": "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "gene_name": "SUCLG2", "organism": "Bovine", "refseq_name": "succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001029811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029811", "type": "external" } ], "gene_names_uniprotkb": "SUCLG2", "gene_names_refseq": "G-SCS; GTPSCS; SUCLG2", "protein_names_uniprotkb": "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; 6.2.1.-; 6.2.1.4; G-SCS; GTP-specific succinyl-CoA synthetase subunit beta; GTPSCS; Itaconyl--CoA ligase [GDP-forming] subunit beta; Malyl--CoA ligase [GDP-forming] subunit beta; SCS-betaG; Succinyl-CoA synthetase beta-G chain", "protein_names_refseq": "GTP-specific succinyl-CoA synthetase subunit beta; SCS-betaG; itaconyl--CoA ligase [GDP-forming] subunit beta; malyl--CoA ligase [GDP-forming] subunit beta; succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial precursor; succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; succinate-CoA ligase GDP-forming beta subunit; succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial; succinyl-CoA synthetase beta-G chain", "tax_id": 9913, "disease": "", "pathway": " (bta:537713); (R-BTA-71403); (R-BTA-9837999)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as a GTP-specific itaconyl- and malyl-CoA synthetase., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "6.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.9", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0004776 succinate-CoA ligase (GDP-forming) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042709 succinate-CoA ligase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006104 succinyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHX5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHX6-1", "uniprot_id": [ { "id": "OS9_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHX6", "type": "external" } ], "mass": 75779.0, "length": 667, "protein_name": "Protein OS-9", "gene_name": "OS9", "organism": "Bovine", "refseq_name": "protein OS-9 precursor", "refseq_ac": [ { "id": "NP_001029397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029397", "type": "external" } ], "gene_names_uniprotkb": "OS9", "gene_names_refseq": "OS9", "protein_names_uniprotkb": "Protein OS-9", "protein_names_refseq": "amplified in osteosarcoma; osteosarcoma amplified 9, endoplasmic reticulum associated protein; protein OS-9 precursor; protein OS-9", "tax_id": 9913, "disease": "", "pathway": " (bta:504832)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 as well as hyperglycosylated HSP90B1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:0034976 response to endoplasmic reticulum stress;GO:0006621 protein retention in ER lumen", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHX6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHZ4-1", "uniprot_id": [ { "id": "TGFI1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHZ4", "type": "external" } ], "mass": 49452.0, "length": 456, "protein_name": "Transforming growth factor beta-1-induced transcript 1 protein", "gene_name": "TGFB1I1", "organism": "Bovine", "refseq_name": "transforming growth factor beta-1-induced transcript 1 protein", "refseq_ac": [ { "id": "NP_001030390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030390", "type": "external" } ], "gene_names_uniprotkb": "TGFB1I1", "gene_names_refseq": "TGFB1I1", "protein_names_uniprotkb": "Transforming growth factor beta-1-induced transcript 1 protein; Hic-5; Hydrogen peroxide-inducible clone 5 protein", "protein_names_refseq": "hic-5; hydrogen peroxide-inducible clone 5 protein; transforming growth factor beta-1-induced transcript 1 protein", "tax_id": 9913, "disease": "", "pathway": " (bta:515834)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15333043;17337598", "class_list": "", "function": "Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding;GO:0050681 nuclear androgen receptor binding;GO:0048495 Roundabout binding;GO:0070411 I-SMAD binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005911 cell-cell junction;GO:0005925 focal adhesion;GO:0016363 nuclear matrix", "go_biological_process": "GO:0030154 cell differentiation;GO:0034446 substrate adhesion-dependent cell spreading;GO:0043542 endothelial cell migration;GO:0016055 Wnt signaling pathway;GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3MHZ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MI03-1", "uniprot_id": [ { "id": "OGFD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MI03", "type": "external" } ], "mass": 62747.0, "length": 542, "protein_name": "Prolyl 3-hydroxylase OGFOD1", "gene_name": "OGFOD1", "organism": "Bovine", "refseq_name": "prolyl 3-hydroxylase OGFOD1", "refseq_ac": [ { "id": "NP_001160085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160085", "type": "external" } ], "gene_names_uniprotkb": "OGFOD1", "gene_names_refseq": "OGFOD1", "protein_names_uniprotkb": "Prolyl 3-hydroxylase OGFOD1; 1.14.11.-; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1; uS12 prolyl 3-hydroxylase", "protein_names_refseq": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1; prolyl 3-hydroxylase OGFOD1; uS12 prolyl 3-hydroxylase", "tax_id": 9913, "disease": "", "pathway": " (bta:514141); (R-BTA-9629569)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0031543 peptidyl-proline dioxygenase activity;GO:0031544 peptidyl-proline 3-dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0008283 cell population proliferation;GO:0034063 stress granule assembly;GO:0018126 protein hydroxylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MI03-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWX5-1", "uniprot_id": [ { "id": "CADH6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SWX5", "type": "external" } ], "mass": 88309.0, "length": 790, "protein_name": "Cadherin-6", "gene_name": "CDH6", "organism": "Bovine", "refseq_name": "cadherin-6 precursor", "refseq_ac": [ { "id": "NP_001029812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029812", "type": "external" } ], "gene_names_uniprotkb": "CDH6", "gene_names_refseq": "CDH6", "protein_names_uniprotkb": "Cadherin-6", "protein_names_refseq": "cadherin 6, type 2, K-cadherin (fetal kidney); cadherin-6 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:537946); (R-BTA-418990)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWX5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWY3-1", "uniprot_id": [ { "id": "IMDH2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SWY3", "type": "external" } ], "mass": 55763.0, "length": 514, "protein_name": "Inosine-5'-monophosphate dehydrogenase 2", "gene_name": "IMPDH2", "organism": "Bovine", "refseq_name": "inosine-5'-monophosphate dehydrogenase 2", "refseq_ac": [ { "id": "NP_001029588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029588", "type": "external" } ], "gene_names_uniprotkb": "IMPDH2", "gene_names_refseq": "IMPDH2", "protein_names_uniprotkb": "Inosine-5'-monophosphate dehydrogenase 2; 1.1.1.205; IMP dehydrogenase 2; IMPD 2; IMPDH 2; IMPDH-II", "protein_names_refseq": "IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMPD 2; IMPDH 2; IMPDH-II; inosine-5'-monophosphate dehydrogenase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:511969); (R-BTA-6798695); (R-BTA-73817); (R-BTA-9748787)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "1.7.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0003938 IMP dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007623 circadian rhythm;GO:0006177 GMP biosynthetic process;GO:0006183 GTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWY3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWZ4-1", "uniprot_id": [ { "id": "EXOS9_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SWZ4", "type": "external" } ], "mass": 49150.0, "length": 440, "protein_name": "Exosome complex component RRP45", "gene_name": "EXOSC9", "organism": "Bovine", "refseq_name": "exosome complex component RRP45", "refseq_ac": [ { "id": "NP_001030225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030225", "type": "external" } ], "gene_names_uniprotkb": "EXOSC9", "gene_names_refseq": "EXOSC9", "protein_names_uniprotkb": "Exosome complex component RRP45; Exosome component 9", "protein_names_refseq": "exosome complex component RRP45; exosome complex exonuclease RRP45", "tax_id": 9913, "disease": "", "pathway": " (bta:508005)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000176 nuclear exosome (RNase complex);GO:0000228 nuclear chromosome;GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0034473 U1 snRNA 3'-end processing;GO:0034476 U5 snRNA 3'-end processing;GO:0016075 rRNA catabolic process;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWZ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWZ7-1", "uniprot_id": [ { "id": "TCAB1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SWZ7", "type": "external" } ], "mass": 59108.0, "length": 540, "protein_name": "Telomerase Cajal body protein 1", "gene_name": "WRAP53", "organism": "Bovine", "refseq_name": "telomerase Cajal body protein 1", "refseq_ac": [ { "id": "NP_001030245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030245", "type": "external" } ], "gene_names_uniprotkb": "WRAP53; TCAB1; WDR79", "gene_names_refseq": "WDR79; WRAP53", "protein_names_uniprotkb": "Telomerase Cajal body protein 1; WD repeat-containing protein 79; WD40 repeat-containing protein antisense to TP53 gene homolog", "protein_names_refseq": "WD repeat domain 79; WD repeat-containing protein 79; WD repeat-containing protein WRAP53; WD40 repeat-containing protein antisense to TP53 gene homolog; WD40 repeat-containing protein encoded by RNA antisense to p53; telomerase Cajal body protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:509631)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity. In addition, also controls telomerase holoenzyme complex localization to Cajal body. During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity. In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies. Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks. Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0035861 site of double-strand break;GO:0015030 Cajal body;GO:0005697 telomerase holoenzyme complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0090666 scaRNA localization to Cajal body;GO:0034337 RNA folding;GO:0032203 telomere formation via telomerase;GO:1904867 protein localization to Cajal body", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWZ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWZ8-1", "uniprot_id": [ { "id": "LMO4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SWZ8", "type": "external" } ], "mass": 17994.0, "length": 165, "protein_name": "LIM domain transcription factor LMO4", "gene_name": "LMO4", "organism": "Bovine", "refseq_name": "LIM domain transcription factor LMO4", "refseq_ac": [ { "id": "NP_001029923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029923", "type": "external" } ], "gene_names_uniprotkb": "LMO4", "gene_names_refseq": "LMO4", "protein_names_uniprotkb": "LIM domain transcription factor LMO4; LIM domain only protein 4; LMO-4", "protein_names_refseq": "LIM domain only protein 4; LIM domain transcription factor LMO4; LMO-4", "tax_id": 9913, "disease": "", "pathway": " (bta:614212)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription cofactor. Plays a role in establishing motor neuron identity, in concert with MNX1, acting, at least in part, to disrupt LDB1-LHX3 complexes thereby negatively modulating interneuron genes in motor neurons., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031252 cell leading edge", "go_biological_process": "GO:0050793 regulation of developmental process;GO:0021520 spinal cord motor neuron cell fate specification;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0033674 positive regulation of kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWZ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SX14-1", "uniprot_id": [ { "id": "GELS_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SX14", "type": "external" } ], "mass": 80731.0, "length": 731, "protein_name": "Gelsolin", "gene_name": "GSN", "organism": "Bovine", "refseq_name": "gelsolin isoform b", "refseq_ac": [ { "id": "NP_001029799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029799", "type": "external" } ], "gene_names_uniprotkb": "GSN", "gene_names_refseq": "GSN", "protein_names_uniprotkb": "Gelsolin; ADF; Actin-depolymerizing factor; Brevin", "protein_names_refseq": "ADF; actin-depolymerizing factor; brevin; gelsolin (amyloidosis, Finnish type); gelsolin isoform b", "tax_id": 9913, "disease": "", "pathway": " (bta:535077)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26495903;34019948", "class_list": "", "function": "Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (By similarity). Plays a role in ciliogenesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007417 central nervous system development;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0060271 cilium assembly;GO:0051014 actin filament severing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3SX14-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SX26-1", "uniprot_id": [ { "id": "TRIP6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SX26", "type": "external" } ], "mass": 50883.0, "length": 481, "protein_name": "Thyroid receptor-interacting protein 6", "gene_name": "TRIP6", "organism": "Bovine", "refseq_name": "thyroid receptor-interacting protein 6", "refseq_ac": [ { "id": "NP_001030546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030546", "type": "external" } ], "gene_names_uniprotkb": "TRIP6", "gene_names_refseq": "TRIP6", "protein_names_uniprotkb": "Thyroid receptor-interacting protein 6; TR-interacting protein 6; TRIP-6", "protein_names_refseq": "TR-interacting protein 6; TRIP-6; thyroid receptor-interacting protein 6", "tax_id": 9913, "disease": "", "pathway": " (bta:615869)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0019900 kinase binding;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005925 focal adhesion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0030335 positive regulation of cell migration;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SX26-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SX43-1", "uniprot_id": [ { "id": "RRAGA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SX43", "type": "external" } ], "mass": 36566.0, "length": 313, "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "organism": "Bovine", "refseq_name": "ras-related GTP-binding protein A", "refseq_ac": [ { "id": "NP_001030576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030576", "type": "external" } ], "gene_names_uniprotkb": "RRAGA", "gene_names_refseq": "RRAGA", "protein_names_uniprotkb": "Ras-related GTP-binding protein A; 3.6.5.-; Rag A; RagA", "protein_names_refseq": "rag A; ragA; ras-related GTP-binding protein A", "tax_id": 9913, "disease": "", "pathway": " (bta:618207); (R-BTA-1632852); (R-BTA-165159); (R-BTA-166208); (R-BTA-380972); (R-BTA-5628897); (R-BTA-8866654); (R-BTA-8943724); (R-BTA-9639288)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagA/RRAGA is in its active form when GTP-bound RagA/RRAGA forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagA/RRAGA heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF signaling pathway leading to induction of cell death., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:1990131 Gtr1-Gtr2 GTPase complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006915 apoptotic process;GO:0010507 negative regulation of autophagy;GO:0008104 intracellular protein localization;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SX43-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYT1-1", "uniprot_id": [ { "id": "DPH1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYT1", "type": "external" } ], "mass": 47978.0, "length": 438, "protein_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1", "gene_name": "DPH1", "organism": "Bovine", "refseq_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1", "refseq_ac": [ { "id": "NP_001070367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070367", "type": "external" } ], "gene_names_uniprotkb": "DPH1", "gene_names_refseq": "DPH1-OVCA2; DPH1", "protein_names_uniprotkb": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; 2.5.1.108; Diphthamide biosynthesis protein 1; Diphtheria toxin resistance protein 1; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1", "protein_names_refseq": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1; diphthamide biosynthesis protein 1; diphtheria toxin resistance protein 1; diptheria toxin resistance protein required for diphthamide biosynthesis-like 1", "tax_id": 9913, "disease": "", "pathway": " (bta:534099)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.108", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0120513 2-(3-amino-3-carboxypropyl)histidine synthase complex", "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SYT1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYT8-1", "uniprot_id": [ { "id": "NCPR_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYT8", "type": "external" } ], "mass": 77021.0, "length": 678, "protein_name": "NADPH--cytochrome P450 reductase", "gene_name": "POR", "organism": "Bovine", "refseq_name": "NADPH--cytochrome P450 reductase", "refseq_ac": [ { "id": "NP_001030467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030467", "type": "external" } ], "gene_names_uniprotkb": "POR", "gene_names_refseq": "P450R; POR", "protein_names_uniprotkb": "NADPH--cytochrome P450 reductase; 1.6.2.4; CPR; P450R", "protein_names_refseq": "CPR; NADPH--cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; cytochrome P450 reductase", "tax_id": 9913, "disease": "", "pathway": " (bta:532512)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.4", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0010181 FMN binding;GO:0050661 NADP binding;GO:0003958 NADPH-hemoprotein reductase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009725 response to hormone;GO:0006809 nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SYT8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYU1-1", "uniprot_id": [ { "id": "NOC2L_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYU1", "type": "external" } ], "mass": 84744.0, "length": 746, "protein_name": "Nucleolar complex protein 2 homolog", "gene_name": "NOC2L", "organism": "Bovine", "refseq_name": "nucleolar complex protein 2 homolog", "refseq_ac": [ { "id": "NP_001029498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029498", "type": "external" } ], "gene_names_uniprotkb": "NOC2L; NIR", "gene_names_refseq": "NOC2L", "protein_names_uniprotkb": "Nucleolar complex protein 2 homolog; NOC2-like protein; Novel INHAT repressor; Protein NOC2 homolog", "protein_names_refseq": "NOC2-like protein; novel INHAT repressor; nucleolar complex associated 2 homolog; nucleolar complex protein 2 homolog; protein NOC2 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:508638); (R-BTA-6804756)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030690 Noc1p-Noc2p complex;GO:0030691 Noc2p-Noc3p complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0042273 ribosomal large subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SYU1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYU2-1", "uniprot_id": [ { "id": "EF2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYU2", "type": "external" } ], "mass": 95368.0, "length": 858, "protein_name": "Elongation factor 2", "gene_name": "EEF2", "organism": "Bovine", "refseq_name": "elongation factor 2", "refseq_ac": [ { "id": "NP_001068589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068589", "type": "external" } ], "gene_names_uniprotkb": "EEF2", "gene_names_refseq": "EEF2; EF-2", "protein_names_uniprotkb": "Elongation factor 2; 3.6.5.-; EF-2", "protein_names_refseq": "elongation factor 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281138); (R-BTA-156902); (R-BTA-5358493); (R-BTA-6798695); (R-BTA-8876725)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "21394738", "class_list": "", "function": "Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Eukaryotic elongation factor-2 (eEF2) may be a limiting factor in milk protein synthesis (Review) Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.5.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.108", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": 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"type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "6.3.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.14", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "2.1.1.314", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.314", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0005840 ribosome", "go_biological_process": "GO:0045727 positive regulation of translation;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SYU2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYW1-1", "uniprot_id": [ { "id": "AP1M2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYW1", "type": "external" } ], "mass": 48150.0, "length": 423, "protein_name": "AP-1 complex subunit mu-2", "gene_name": "AP1M2", "organism": "Bovine", "refseq_name": "AP-1 complex subunit mu-2", "refseq_ac": [ { "id": "NP_001029683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029683", "type": "external" } ], "gene_names_uniprotkb": "AP1M2", "gene_names_refseq": "AP1M2", "protein_names_uniprotkb": "AP-1 complex subunit mu-2; AP-mu chain family member mu1B; Adaptor protein complex AP-1 subunit mu-2; Adaptor-related protein complex 1 subunit mu-2; Clathrin assembly protein complex 1 mu-2 medium chain 2; Golgi adaptor HA1/AP1 adaptin mu-2 subunit; Mu-adaptin 2; Mu1B-adaptin", "protein_names_refseq": "AP-1 complex subunit mu-2; AP-mu chain family member mu1B; adaptor protein complex AP-1 mu-2 subunit; adaptor protein complex AP-1 subunit mu-2; adaptor related protein complex 1 mu 2 subunit; clathrin assembly protein complex 1 medium chain 2; clathrin assembly protein complex 1 mu-2 medium chain 2; golgi adaptor HA1/AP1 adaptin mu-2 subunit; mu-adaptin 2; mu1B-adaptin", "tax_id": 9913, "disease": "", "pathway": " (bta:515766); (R-BTA-2132295); (R-BTA-432720); (R-BTA-432722)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "12604586", "class_list": "", "function": "Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005802 trans-Golgi network;GO:0030121 AP-1 adaptor complex;GO:0030665 clathrin-coated vesicle membrane;GO:0030131 clathrin adaptor complex;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006896 Golgi to vacuole transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SYW1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYW2-1", "uniprot_id": [ { "id": "CO2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYW2", "type": "external" } ], "mass": 82906.0, "length": 750, "protein_name": "Complement C2", "gene_name": "C2", "organism": "Bovine", "refseq_name": "complement C2 precursor", "refseq_ac": [ { "id": "NP_001029664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029664", "type": "external" } ], "gene_names_uniprotkb": "C2", "gene_names_refseq": "C2", "protein_names_uniprotkb": "Complement C2; C3/C5 convertase", "protein_names_refseq": "C3/C5 convertase; complement C2 precursor; complement component 2", "tax_id": 9913, "disease": "", "pathway": " (bta:515440); (R-BTA-166663); (R-BTA-174577); (R-BTA-977606)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic component of the complement C3 and C5 convertase complexes. Following complement activation, recruited to the surface of pathogens by complement C4b opsonin to form the C3 convertase, or C3b and C4b opsonins to form the C5 convertase. As part of the C3 convertase, cleaves and activate C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. As part of the C5 convertase, cleaves and activate C5 into C5a anaphylatoxin and C5b component of the membrane attack complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Component C2 is part of the classical, lectin and GZMK complement systems., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0009986 cell surface;GO:0005601 classical-complement-pathway C3/C5 convertase complex;GO:0106139 symbiont cell surface;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0009617 response to bacterium;GO:0001867 complement activation, lectin pathway;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SYW2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYY9-1", "uniprot_id": [ { "id": "LMBD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYY9", "type": "external" } ], "mass": 62022.0, "length": 543, "protein_name": "Lysosomal cobalamin transport escort protein LMBD1", "gene_name": "LMBRD1", "organism": "Bovine", "refseq_name": "lysosomal cobalamin transport escort protein LMBD1", "refseq_ac": [ { "id": "NP_001030264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030264", "type": "external" } ], "gene_names_uniprotkb": "LMBRD1", "gene_names_refseq": "LMBD1; LMBRD1", "protein_names_uniprotkb": "Lysosomal cobalamin transport escort protein LMBD1; LMBD1; LMBR1 domain-containing protein 1", "protein_names_refseq": "LMBR1 domain-containing protein 1; lysosomal cobalamin transport escort protein LMBD1; probable lysosomal cobalamin transporter", "tax_id": 9913, "disease": "", "pathway": " (bta:510495)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035612 AP-2 adaptor complex binding;GO:0031419 cobalamin binding;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030136 clathrin-coated vesicle;GO:0045334 clathrin-coated endocytic vesicle", "go_biological_process": "GO:0072583 clathrin-dependent endocytosis;GO:0007369 gastrulation;GO:0038016 insulin receptor internalization;GO:0061462 protein localization to lysosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SYY9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYZ3-1", "uniprot_id": [ { "id": "CR3L3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYZ3", "type": "external" } ], "mass": 48689.0, "length": 456, "protein_name": "Cyclic AMP-responsive element-binding protein 3-like protein 3", "gene_name": "CREB3L3", "organism": "Bovine", "refseq_name": "cyclic AMP-responsive element-binding protein 3-like protein 3", "refseq_ac": [ { "id": "NP_001029604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029604", "type": "external" } ], "gene_names_uniprotkb": "CREB3L3", "gene_names_refseq": "CREB3L3", "protein_names_uniprotkb": "Cyclic AMP-responsive element-binding protein 3-like protein 3; cAMP-responsive element-binding protein 3-like protein 3", "protein_names_refseq": "cAMP-responsive element-binding protein 3-like protein 3; cyclic AMP-responsive element-binding protein 3-like protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:513010); (R-BTA-8874211)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression (By similarity). Regulates FGF21 transcription (By similarity). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006986 response to unfolded protein;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SYZ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZB8-1", "uniprot_id": [ { "id": "H3CL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZB8", "type": "external" } ], "mass": 15678.0, "length": 136, "protein_name": "Histone H3.3C-like", "gene_name": "", "organism": "Bovine", "refseq_name": "histone H3.3C-like", "refseq_ac": [ { "id": "NP_001069659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069659", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "H3-3D; H3-5; H3F3C", "protein_names_uniprotkb": "Histone H3.3C-like", "protein_names_refseq": "H3.5 histone; histone H3-like; histone H3.3C-like; histone H3.3C", "tax_id": 9913, "disease": "", "pathway": " (bta:539855)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007080 mitotic metaphase chromosome alignment;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZB8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZC2-1", "uniprot_id": [ { "id": "PSB9_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZC2", "type": "external" } ], "mass": 23404.0, "length": 219, "protein_name": "Proteasome subunit beta type-9", "gene_name": "PSMB9", "organism": "Bovine", "refseq_name": "proteasome subunit beta type-9", "refseq_ac": [ { "id": "NP_001029560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029560", "type": "external" } ], "gene_names_uniprotkb": "PSMB9", "gene_names_refseq": "LMP2; PSMB9", "protein_names_uniprotkb": "Proteasome subunit beta type-9; 3.4.25.1; Proteasome subunit beta-1i", "protein_names_refseq": "proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2); proteasome subunit beta 9; proteasome subunit beta type-9; proteasome subunit beta-1i; proteasome subunit, beta type 9 (large multifuntional protease 2)", "tax_id": 9913, "disease": "", "pathway": " (bta:510593); (R-BTA-1236974); (R-BTA-1236978); (R-BTA-9907900); (R-BTA-9912633)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "16573526", "class_list": "", "function": "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:1990111 spermatoproteasome complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005839 proteasome core complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SZC2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZF8-1", "uniprot_id": [ { "id": "SMD2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZF8", "type": "external" } ], "mass": 13527.0, "length": 118, "protein_name": "Small nuclear ribonucleoprotein Sm D2", "gene_name": "SNRPD2", "organism": "Bovine", "refseq_name": "small nuclear ribonucleoprotein Sm D2", "refseq_ac": [ { "id": "NP_001029648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029648", "type": "external" } ], "gene_names_uniprotkb": "SNRPD2", "gene_names_refseq": "SNRPD2", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein Sm D2; Sm-D2; snRNP core protein D2", "protein_names_refseq": "sm-D2; small nuclear ribonucleoprotein D2 polypeptide 16.5kDa; small nuclear ribonucleoprotein Sm D2; snRNP core protein D2", "tax_id": 9913, "disease": "", "pathway": " (bta:514932); (R-BTA-191859); (R-BTA-72163); (R-BTA-72165); (R-BTA-9770562); (R-BTA-9943411)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005829 cytosol;GO:0034709 methylosome;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZF8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZI8-1", "uniprot_id": [ { "id": "IVD_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZI8", "type": "external" } ], "mass": 46498.0, "length": 426, "protein_name": "Isovaleryl-CoA dehydrogenase, mitochondrial", "gene_name": "IVD", "organism": "Bovine", "refseq_name": "isovaleryl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001029554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029554", "type": "external" } ], "gene_names_uniprotkb": "IVD", "gene_names_refseq": "IVD", "protein_names_uniprotkb": "Isovaleryl-CoA dehydrogenase, mitochondrial; 1.3.8.1; 1.3.8.4; Butyryl-CoA dehydrogenase; IVD", "protein_names_refseq": "butyryl-CoA dehydrogenase; isovaleryl Coenzyme A dehydrogenase; isovaleryl-CoA dehydrogenase, mitochondrial precursor; isovaleryl-CoA dehydrogenase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:510440); (R-BTA-70895)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "A mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism, where isovaleryl-CoA (3-methylbutanoyl-CoA) is metabolized to 3-methylbut-2-enoyl-CoA. To a lesser extent, it also participates in the first step in fatty acid beta-oxidation, in which it catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of other saturated short-chain acyl-CoA thioesters such as pentanoyl-CoA, hexanoyl-CoA and butanoyl-CoA, using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.4", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" } ], "go_molecular_function": "GO:0008470 3-methylbutanoyl-CoA dehydrogenase activity;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0009083 branched-chain amino acid catabolic process;GO:0006552 L-leucine catabolic process;GO:0044281 small molecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZI8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZJ0-1", "uniprot_id": [ { "id": "ARLY_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZJ0", "type": "external" } ], "mass": 52743.0, "length": 473, "protein_name": "Argininosuccinate lyase", "gene_name": "ASL", "organism": "Bovine", "refseq_name": "argininosuccinate lyase", "refseq_ac": [ { "id": "NP_001029600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029600", "type": "external" } ], "gene_names_uniprotkb": "ASL", "gene_names_refseq": "ASAL; ASL", "protein_names_uniprotkb": "Argininosuccinate lyase; 4.3.2.1; ASAL; Arginosuccinase", "protein_names_refseq": "argininosuccinate lyase; arginosuccinase", "tax_id": 9913, "disease": "", "pathway": " (bta:512771); (R-BTA-70635)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues (By similarity). Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.1", "type": "external" } ], "go_molecular_function": "GO:0004056 argininosuccinate lyase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0000050 urea cycle;GO:0006526 L-arginine biosynthetic process;GO:0042450 L-arginine biosynthetic process via ornithine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZJ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZP2-1", "uniprot_id": [ { "id": "MARE2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZP2", "type": "external" } ], "mass": 36988.0, "length": 326, "protein_name": "Microtubule-associated protein RP/EB family member 2", "gene_name": "MAPRE2", "organism": "Bovine", "refseq_name": "microtubule-associated protein RP/EB family member 2", "refseq_ac": [ { "id": "NP_001029546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029546", "type": "external" } ], "gene_names_uniprotkb": "MAPRE2", "gene_names_refseq": "MAPRE2", "protein_names_uniprotkb": "Microtubule-associated protein RP/EB family member 2", "protein_names_refseq": "microtubule-associated protein RP/EB family member 2", "tax_id": 9913, "disease": "", "pathway": " (bta:510159)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (By similarity). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation. Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0051233 spindle midzone;GO:0005815 microtubule organizing center;GO:0005881 cytoplasmic microtubule;GO:0035371 microtubule plus-end", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051301 cell division;GO:0051225 spindle assembly;GO:0035372 protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZP2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZR8-1", "uniprot_id": [ { "id": "SRSF3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZR8", "type": "external" } ], "mass": 19330.0, "length": 164, "protein_name": "Serine/arginine-rich splicing factor 3", "gene_name": "SRSF3", "organism": "Bovine", "refseq_name": "serine/arginine-rich splicing factor 3", "refseq_ac": [ { "id": "NP_001029872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029872", "type": "external" } ], "gene_names_uniprotkb": "SRSF3; SFRS3", "gene_names_refseq": "SFRS3; SRSF3", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 3; Splicing factor, arginine/serine-rich 3", "protein_names_refseq": "serine/arginine-rich splicing factor 3; splicing factor, arginine/serine-rich 3", "tax_id": 9913, "disease": "", "pathway": " (bta:540276); (R-BTA-159236); (R-BTA-72163); (R-BTA-72203); (R-BTA-9770562)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0160134 protein-RNA sequence-specific adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0008380 RNA splicing;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZR8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZW1-1", "uniprot_id": [ { "id": "TSSK1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZW1", "type": "external" } ], "mass": 41569.0, "length": 367, "protein_name": "Testis-specific serine/threonine-protein kinase 1", "gene_name": "TSSK1B", "organism": "Bovine", "refseq_name": "testis-specific serine/threonine-protein kinase 1", "refseq_ac": [ { "id": "NP_001077179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077179", "type": "external" } ], "gene_names_uniprotkb": "TSSK1B; TSSK1", "gene_names_refseq": "TSK1; TSSK1B", "protein_names_uniprotkb": "Testis-specific serine/threonine-protein kinase 1; 2.7.11.1; TSK-1; TSK1; TSSK-1; Testis-specific kinase 1", "protein_names_refseq": "TSK-1; TSSK-1; testis-specific kinase 1; testis-specific serine kinase 1; testis-specific serine/threonine-protein kinase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:529193)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031514 motile cilium;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007286 spermatid development;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZW1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T000-1", "uniprot_id": [ { "id": "YKT6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T000", "type": "external" } ], "mass": 22467.0, "length": 198, "protein_name": "Synaptobrevin homolog YKT6", "gene_name": "YKT6", "organism": "Bovine", "refseq_name": "synaptobrevin homolog YKT6", "refseq_ac": [ { "id": "NP_001030219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030219", "type": "external" } ], "gene_names_uniprotkb": "YKT6", "gene_names_refseq": "YKT6", "protein_names_uniprotkb": "Synaptobrevin homolog YKT6; 2.3.1.-", "protein_names_refseq": "SNARE protein Ykt6; synaptobrevin homolog YKT6", "tax_id": 9913, "disease": "", "pathway": " (bta:507409); (R-BTA-204005); (R-BTA-6807878); (R-BTA-6811438); (R-BTA-8980692); (R-BTA-9013148); (R-BTA-9013408); (R-BTA-9013423)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment (By similarity). Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5 (By similarity). Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5 (By similarity). Has a S-palmitoyl transferase activity (By similarity). Essential for the structural and functional organization of the Golgi apparatus (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0005484 SNAP receptor activity;GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006903 vesicle targeting;GO:0006904 vesicle docking involved in exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T000-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T013-1", "uniprot_id": [ { "id": "BNI3L_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T013", "type": "external" } ], "mass": 23846.0, "length": 219, "protein_name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like", "gene_name": "BNIP3L", "organism": "Bovine", "refseq_name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like", "refseq_ac": [ { "id": "NP_001029786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029786", "type": "external" } ], "gene_names_uniprotkb": "BNIP3L", "gene_names_refseq": "BNIP3L", "protein_names_uniprotkb": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like", "protein_names_refseq": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BCL2/adenovirus E1B 19kD-interacting protein 3-like; BCL2/adenovirus E1B 19kDa interacting protein 3-like", "tax_id": 9913, "disease": "", "pathway": " (bta:534615); (R-BTA-6803204)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May function as a tumor suppressor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D9C5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0051607 defense response to virus;GO:0035694 mitochondrial protein catabolic process;GO:0043067 regulation of programmed cell death;GO:0097345 mitochondrial outer membrane permeabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3T013-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T014-1", "uniprot_id": [ { "id": "PMGE_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T014", "type": "external" } ], "mass": 30061.0, "length": 259, "protein_name": "Bisphosphoglycerate mutase", "gene_name": "BPGM", "organism": "Bovine", "refseq_name": "bisphosphoglycerate mutase", "refseq_ac": [ { "id": "NP_001030479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030479", "type": "external" } ], "gene_names_uniprotkb": "BPGM", "gene_names_refseq": "BPGM", "protein_names_uniprotkb": "Bisphosphoglycerate mutase; 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; 5.4.2.11; 5.4.2.4; BPG-dependent PGAM; BPGM", "protein_names_refseq": "2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; BPG-dependent PGAM; bisphosphoglycerate mutase", "tax_id": 9913, "disease": "", "pathway": " (bta:533785)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" } ], "go_molecular_function": "GO:0004082 bisphosphoglycerate mutase activity;GO:0004619 phosphoglycerate mutase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T014-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MJJ0-1", "uniprot_id": [ { "id": "F1MJJ0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MJJ0", "type": "external" } ], "mass": 510109.0, "length": 4486, "protein_name": "Dynein axonemal heavy chain 9", "gene_name": "DNAH17; DNAH9", "organism": "Bovine", "refseq_name": "dynein axonemal heavy chain 9 isoform X1", "refseq_ac": [ { "id": "XP_024836319", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836319", "type": "external" } ], "gene_names_uniprotkb": "DNAH17; DNAH9; DNAH9", "gene_names_refseq": "Bv2; DNAH9", "protein_names_uniprotkb": "Dynein axonemal heavy chain 9", "protein_names_refseq": "dynein axonemal heavy chain 9 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "39743588", "class_list": "", "function": "Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Key component of dynein, a family of motor proteins essential for movement along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of cilia. Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating., [UniProtKB, UniProtKB]; Force generating protein required for cilia beating in respiratory epithelia. Produces force towards the minus ends of microtubules. Key component of dynein, a family of motor proteins essential for movement along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of cilia., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005930 axoneme;GO:0030286 dynein complex;GO:0097729 9+2 motile cilium;GO:0097229 sperm end piece", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MJJ0-1", "record_type": "protein", "filter_code": "0000000.0000100.000100.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MKW9-1", "uniprot_id": [ { "id": "F1MKW9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MKW9", "type": "external" } ], "mass": 105350.0, "length": 969, "protein_name": "Nuclear factor NF-kappa-B p105 subunit", "gene_name": "NFKB1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NFKB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear factor NF-kappa-B p105 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1169091); (R-BTA-1810476); (R-BTA-193692); (R-BTA-202424); (R-BTA-209560); (R-BTA-2871837); (R-BTA-3134963); (R-BTA-3214841); (R-BTA-445989); (R-BTA-448706); (R-BTA-5607764); (R-BTA-5621575); (R-BTA-5684264); (R-BTA-6798695); (R-BTA-9020702); (R-BTA-933542); (R-BTA-9860927); (R-BTA-9958825)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor. Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B. Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding;GO:0003682 chromatin binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex;GO:0033256 I-kappaB/NF-kappaB complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0010557 positive regulation of macromolecule biosynthetic process;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0071222 cellular response to lipopolysaccharide;GO:0071356 cellular response to tumor necrosis factor", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MKW9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MW45-1", "uniprot_id": [ { "id": "F1MW45_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MW45", "type": "external" } ], "mass": 77559.0, "length": 685, "protein_name": "ATP-dependent RNA helicase", "gene_name": "DDX55", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DDX55", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent RNA helicase; 3.6.4.13", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable ATP-binding RNA helicase. Has ATPase activity and is involved in the maturation of precursor large subunit rRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RNA helicase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MW45-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MKT2-1", "uniprot_id": [ { "id": "F1MKT2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MKT2", "type": "external" } ], "mass": 82722.0, "length": 744, "protein_name": "Zona pellucida sperm-binding protein 2", "gene_name": "ZP2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ZP2", "gene_names_refseq": "", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 2; Zona pellucida glycoprotein 2; Zona pellucida protein A", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2534343)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035804 structural constituent of egg coat;GO:0032190 acrosin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0035805 egg coat;GO:0005783 endoplasmic reticulum;GO:0005771 multivesicular body", "go_biological_process": "GO:0007338 single fertilization;GO:0007339 binding of sperm to zona pellucida;GO:0060468 prevention of polyspermy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MKT2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MKI1-1", "uniprot_id": [ { "id": "F1MKI1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MKI1", "type": "external" } ], "mass": 160888.0, "length": 1505, "protein_name": "Copper-transporting ATPase 2", "gene_name": "ATP7B", "organism": "Bovine", "refseq_name": "copper-transporting ATPase 2 isoform X1", "refseq_ac": [ { "id": "XP_002691840", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691840", "type": "external" } ], "gene_names_uniprotkb": "ATP7B", "gene_names_refseq": "ATP7B", "protein_names_uniprotkb": "Copper-transporting ATPase 2; 7.2.2.8; Copper pump 2", "protein_names_refseq": "copper-transporting ATPase 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:518075)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.8", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005507 copper ion binding;GO:0140581 P-type monovalent copper transporter activity;GO:0008551 P-type cadmium transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005770 late endosome;GO:0005802 trans-Golgi network;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0010273 detoxification of copper ion;GO:0015677 copper ion import;GO:0051208 sequestering of calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MKI1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXG4-1", "uniprot_id": [ { "id": "F1MXG4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXG4", "type": "external" } ], "mass": 83160.0, "length": 740, "protein_name": "Protein O-mannosyl-transferase TMTC4", "gene_name": "TMTC4", "organism": "Bovine", "refseq_name": "protein O-mannosyl-transferase TMTC4 isoform X1", "refseq_ac": [ { "id": "XP_024855712", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855712", "type": "external" } ], "gene_names_uniprotkb": "TMTC4", "gene_names_refseq": "TMTC4", "protein_names_uniprotkb": "Protein O-mannosyl-transferase TMTC4; 2.4.1.109; Transmembrane O-mannosyltransferase targeting cadherins 4; Transmembrane and tetratricopeptide repeat-containing 4", "protein_names_refseq": "protein O-mannosyl-transferase TMTC4 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0030968 endoplasmic reticulum unfolded protein response;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXG4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MT67-1", "uniprot_id": [ { "id": "F1MT67_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MT67", "type": "external" } ], "mass": 129824.0, "length": 1174, "protein_name": "NLR family pyrin domain containing 5", "gene_name": "NLRP5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NLRP5", "gene_names_refseq": "", "protein_names_uniprotkb": "NLR family pyrin domain containing 5", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MT67-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MFD2-1", "uniprot_id": [ { "id": "F1MFD2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MFD2", "type": "external" } ], "mass": 204591.0, "length": 1859, "protein_name": "Inactive histone-lysine N-methyltransferase 2E", "gene_name": "KMT2E", "organism": "Bovine", "refseq_name": "inactive histone-lysine N-methyltransferase 2E", "refseq_ac": [ { "id": "NP_001075920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075920", "type": "external" } ], "gene_names_uniprotkb": "KMT2E", "gene_names_refseq": "KMT2E; MLL5", "protein_names_uniprotkb": "Inactive histone-lysine N-methyltransferase 2E", "protein_names_refseq": "inactive histone-lysine N-methyltransferase 2E; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)", "tax_id": 9913, "disease": "", "pathway": " (bta:539121)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry. Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition. During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 0, "predicted_o_glycosites": 11, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005813 centrosome;GO:0016607 nuclear speck;GO:0005694 chromosome;GO:0005829 cytosol;GO:0000791 euchromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:0010468 regulation of gene expression;GO:0051726 regulation of cell cycle;GO:0002446 neutrophil mediated immunity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MFD2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MKX7-1", "uniprot_id": [ { "id": "F1MKX7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MKX7", "type": "external" } ], "mass": 108430.0, "length": 951, "protein_name": "5'-3' exoribonuclease", "gene_name": "XRN2", "organism": "Bovine", "refseq_name": "5'-3' exoribonuclease 2", "refseq_ac": [ { "id": "NP_001179401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179401", "type": "external" } ], "gene_names_uniprotkb": "XRN2", "gene_names_refseq": "XRN2", "protein_names_uniprotkb": "5'-3' exoribonuclease; 3.1.13.-", "protein_names_refseq": "5'-3' exoribonuclease 2", "tax_id": 9913, "disease": "", "pathway": " (bta:517417); (R-BTA-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" } ], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0004534 5'-3' RNA exonuclease activity;GO:0008270 zinc ion binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006397 mRNA processing;GO:0007283 spermatogenesis;GO:0006353 DNA-templated transcription termination;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0006369 termination of RNA polymerase II transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MKX7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MMA0-1", "uniprot_id": [ { "id": "F1MMA0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MMA0", "type": "external" } ], "mass": 95473.0, "length": 895, "protein_name": "Interleukin enhancer binding factor 3", "gene_name": "ILF3", "organism": "Bovine", "refseq_name": "interleukin enhancer-binding factor 3 isoform X2", "refseq_ac": [ { "id": "XP_024850364", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850364", "type": "external" } ], "gene_names_uniprotkb": "ILF3", "gene_names_refseq": "ILF3", "protein_names_uniprotkb": "Interleukin enhancer binding factor 3", "protein_names_refseq": "interleukin enhancer-binding factor 3 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:614936); (R-BTA-9762293); (R-BTA-9833482)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003725 double-stranded RNA binding;GO:0001618 virus receptor activity;GO:0003727 single-stranded RNA binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MMA0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPW9-1", "uniprot_id": [ { "id": "F1MPW9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPW9", "type": "external" } ], "mass": 259856.0, "length": 2349, "protein_name": "C2 domain-containing protein 3", "gene_name": "C2CD3", "organism": "Bovine", "refseq_name": "C2 domain-containing protein 3 isoform X1", "refseq_ac": [ { "id": "XP_059730975", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730975", "type": "external" } ], "gene_names_uniprotkb": "C2CD3", "gene_names_refseq": "C2CD3", "protein_names_uniprotkb": "C2 domain-containing protein 3", "protein_names_refseq": "C2 domain-containing protein 3 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5620912)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation. Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005814 centriole;GO:0034451 centriolar satellite;GO:0005815 microtubule organizing center;GO:0036064 ciliary basal body", "go_biological_process": "GO:0060271 cilium assembly;GO:0071539 protein localization to centrosome;GO:0061511 centriole elongation;GO:1905515 non-motile cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MPW9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1ML98-1", "uniprot_id": [ { "id": "F1ML98_BOVIN", "url": "https://www.uniprot.org/uniprot/F1ML98", "type": "external" } ], "mass": 110707.0, "length": 974, "protein_name": "BICD cargo adaptor 1", "gene_name": "BICD1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "BICD1", "gene_names_refseq": "", "protein_names_uniprotkb": "BICD cargo adaptor 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6811436)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008093 cytoskeletal anchor activity;GO:0070840 dynein complex binding;GO:0019901 protein kinase binding;GO:0031267 small GTPase binding;GO:0034452 dynactin binding", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1904781 positive regulation of protein localization to centrosome;GO:0048260 positive regulation of receptor-mediated endocytosis;GO:0019068 virion assembly;GO:0070507 regulation of microtubule cytoskeleton organization;GO:0072385 minus-end-directed organelle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1ML98-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQ60-1", "uniprot_id": [ { "id": "F1MQ60_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQ60", "type": "external" } ], "mass": 39683.0, "length": 347, "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase", "gene_name": "B3GAT1", "organism": "Bovine", "refseq_name": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X1", "refseq_ac": [ { "id": "XP_024831284", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831284", "type": "external" } ], "gene_names_uniprotkb": "B3GAT1", "gene_names_refseq": "B3GAT1; glcat-p", "protein_names_uniprotkb": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; 2.4.1.135", "protein_names_refseq": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1971475)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.135", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.135", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 21, "hit_score": 0.1, "record_id": "F1MQ60-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MR37-1", "uniprot_id": [ { "id": "F1MR37_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MR37", "type": "external" } ], "mass": 263041.0, "length": 2380, "protein_name": "Voltage-dependent T-type calcium channel subunit alpha", "gene_name": "CACNA1G", "organism": "Bovine", "refseq_name": "voltage-dependent T-type calcium channel subunit alpha-1G", "refseq_ac": [ { "id": "NP_001180069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180069", "type": "external" } ], "gene_names_uniprotkb": "CACNA1G", "gene_names_refseq": "CACNA1G", "protein_names_uniprotkb": "Voltage-dependent T-type calcium channel subunit alpha", "protein_names_refseq": "calcium channel, voltage-dependent, alpha 1G subunit; voltage-dependent T-type calcium channel subunit alpha-1G", "tax_id": 9913, "disease": "", "pathway": " (bta:282411); (R-BTA-445355)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19520861", "class_list": "", "function": "CaV3.1 structural analysis and comparison to CaV1.2 channel, [RefSeq, PubMed]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the `low-voltage activated (LVA)` group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008332 low voltage-gated calcium channel activity;GO:0046872 metal ion binding;GO:0097110 scaffold protein binding;GO:0008331 high voltage-gated calcium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "GO:0070509 calcium ion import;GO:0042391 regulation of membrane potential;GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MR37-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MS53-1", "uniprot_id": [ { "id": "F1MS53_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MS53", "type": "external" } ], "mass": 182674.0, "length": 1637, "protein_name": "Rap guanine nucleotide exchange factor 6", "gene_name": "RAPGEF6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RAPGEF6", "gene_names_refseq": "", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 6", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:789597)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0030742 GTP-dependent protein binding;GO:0070300 phosphatidic acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005829 cytosol;GO:0016324 apical plasma membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0032486 Rap protein signal transduction;GO:0031175 neuron projection development;GO:0007265 Ras protein signal transduction;GO:1903698 positive regulation of microvillus assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MS53-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MMW4-1", "uniprot_id": [ { "id": "F1MMW4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MMW4", "type": "external" } ], "mass": 71496.0, "length": 646, "protein_name": "A-kinase anchoring protein 8 like", "gene_name": "AKAP8L", "organism": "Bovine", "refseq_name": "A-kinase anchor protein 8-like isoform X4", "refseq_ac": [ { "id": "XP_002688606", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688606", "type": "external" } ], "gene_names_uniprotkb": "AKAP8L", "gene_names_refseq": "AKAP8L", "protein_names_uniprotkb": "A-kinase anchoring protein 8 like", "protein_names_refseq": "A-kinase anchor protein 8-like isoform X4", "tax_id": 9913, "disease": "", "pathway": " (bta:539700)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0005521 lamin binding", "go_cellular_component": "GO:0016363 nuclear matrix;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007076 mitotic chromosome condensation;GO:0044839 cell cycle G2/M phase transition;GO:0010793 regulation of mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MMW4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEV5-1", "uniprot_id": [ { "id": "F1MEV5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEV5", "type": "external" } ], "mass": 65105.0, "length": 566, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1", "gene_name": "PFKFB1", "organism": "Bovine", "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X2", "refseq_ac": [ { "id": "XP_024843539", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843539", "type": "external" } ], "gene_names_uniprotkb": "PFKFB1", "gene_names_refseq": "PFKFB1", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1", "protein_names_refseq": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9634600)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003873 6-phosphofructo-2-kinase activity;GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;GO:0005829 cytosol", "go_biological_process": "GO:0006000 fructose metabolic process;GO:0006003 fructose 2,6-bisphosphate metabolic process;GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEV5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXA4-1", "uniprot_id": [ { "id": "F1MXA4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXA4", "type": "external" } ], "mass": 80611.0, "length": 724, "protein_name": "Adducin 2", "gene_name": "ADD2", "organism": "Bovine", "refseq_name": "beta-adducin isoform X1", "refseq_ac": [ { "id": "XP_005212585", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212585", "type": "external" } ], "gene_names_uniprotkb": "ADD2", "gene_names_refseq": "ADD2", "protein_names_uniprotkb": "Adducin 2", "protein_names_refseq": "beta-adducin isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5223345)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005200 structural constituent of cytoskeleton;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0044853 plasma membrane raft;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0051016 barbed-end actin filament capping;GO:0051017 actin filament bundle assembly;GO:0007416 synapse assembly;GO:0050901 leukocyte tethering or rolling;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXA4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MI44-1", "uniprot_id": [ { "id": "F1MI44_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MI44", "type": "external" } ], "mass": 95319.0, "length": 877, "protein_name": "Cadherin-related family member 1", "gene_name": "CDHR1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CDHR1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin-related family member 1; Photoreceptor cadherin; Protocadherin-21", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016342 catenin complex;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0045494 photoreceptor cell maintenance;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MI44-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { 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"2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005956 protein kinase CK2 complex;GO:0031519 PcG protein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:1905818 regulation of chromosome separation;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MJ55-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MFF9-1", "uniprot_id": [ { "id": "F1MFF9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MFF9", "type": "external" } ], "mass": 222914.0, "length": 1954, "protein_name": "Chromodomain helicase DNA binding protein 5", "gene_name": "CHD5", "organism": "Bovine", "refseq_name": "chromodomain-helicase-DNA-binding protein 5 isoform X2", "refseq_ac": [ { "id": "XP_024832538", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832538", "type": "external" } ], "gene_names_uniprotkb": "CHD5", "gene_names_refseq": "CHD5", "protein_names_uniprotkb": "Chromodomain helicase DNA binding protein 5", "protein_names_refseq": "chromodomain-helicase-DNA-binding protein 5 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:530880)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0061628 histone H3K27me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MFF9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MTY4-1", "uniprot_id": [ { "id": "F1MTY4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MTY4", "type": "external" } ], "mass": 117171.0, "length": 1054, "protein_name": "Protein transport protein sec16", "gene_name": "SEC16B", "organism": "Bovine", "refseq_name": "protein transport protein Sec16B isoform X1", "refseq_ac": [ { "id": "XP_015330609", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330609", "type": "external" } ], "gene_names_uniprotkb": "SEC16B", "gene_names_refseq": "LZTR2; Rgpr; SEC16B", "protein_names_uniprotkb": "Protein transport protein sec16", "protein_names_refseq": "protein transport protein Sec16B isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-204005)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0012507 ER to Golgi transport vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0007031 peroxisome organization;GO:0016192 vesicle-mediated transport;GO:0010628 positive regulation of gene expression;GO:0016559 peroxisome fission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MTY4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MTT3-1", "uniprot_id": [ { "id": "F1MTT3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MTT3", "type": "external" } ], "mass": 67235.0, "length": 612, "protein_name": "Coagulation factor XII", "gene_name": "F12", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "F12", "gene_names_refseq": "", "protein_names_uniprotkb": "Coagulation factor XII; 3.4.21.38; Hageman factor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9855719); (R-BTA-9935598); (R-BTA-9970672)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.38", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005791 rough endoplasmic reticulum", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0042730 fibrinolysis;GO:0010756 positive regulation of plasminogen activation;GO:0030194 positive regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MTT3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MVI0-1", "uniprot_id": [ { "id": "F1MVI0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MVI0", "type": "external" } ], "mass": 113306.0, "length": 1018, "protein_name": "Contactin-1", "gene_name": "CNTN1", "organism": "Bovine", "refseq_name": "contactin-1 isoform X1", "refseq_ac": [ { "id": "XP_010803359", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010803359", "type": "external" } ], "gene_names_uniprotkb": "CNTN1", "gene_names_refseq": "CNTN1", "protein_names_uniprotkb": "Contactin-1; Neural cell surface protein F3", "protein_names_refseq": "contactin-1 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane;GO:0098978 glutamatergic synapse;GO:0030424 axon;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0032289 central nervous system myelin formation;GO:0007626 locomotory behavior;GO:0098609 cell-cell adhesion;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MVI0-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MIQ5-1", "uniprot_id": [ { "id": "F1MIQ5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MIQ5", "type": "external" } ], "mass": 62094.0, "length": 551, "protein_name": "Harmonin", "gene_name": "USH1C", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "USH1C", "gene_names_refseq": "", "protein_names_uniprotkb": "Harmonin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030507 spectrin binding", "go_cellular_component": "GO:0042995 cell projection;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005903 brush border;GO:0005902 microvillus", "go_biological_process": "GO:0030154 cell differentiation;GO:0050885 neuromuscular process controlling balance;GO:0007605 sensory perception of sound;GO:1904106 protein localization to microvillus;GO:1904970 brush border assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MIQ5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MJT4-1", "uniprot_id": [ { "id": "F1MJT4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MJT4", "type": "external" } ], "mass": 61961.0, "length": 559, "protein_name": "Perforin-1", "gene_name": "PRF1", "organism": "Bovine", "refseq_name": "perforin-1 isoform X1", "refseq_ac": [ { "id": "XP_005226391", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226391", "type": "external" } ], "gene_names_uniprotkb": "PRF1", "gene_names_refseq": "PRF1", "protein_names_uniprotkb": "Perforin-1; 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"uniprot_canonical_ac": "F1MY79-1", "uniprot_id": [ { "id": "F1MY79_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MY79", "type": "external" } ], "mass": 81790.0, "length": 745, "protein_name": "Semaphorin-4A", "gene_name": "SEMA4A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SEMA4A", "gene_names_refseq": "", "protein_names_uniprotkb": "Semaphorin-4A", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-416700)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0002250 adaptive immune response;GO:0045063 T-helper 1 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MY79-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MF33-1", "uniprot_id": [ { "id": "F1MF33_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MF33", "type": "external" } ], "mass": 64129.0, "length": 554, "protein_name": "Intraflagellar transport protein 56", "gene_name": "IFT56; TTC26", "organism": "Bovine", "refseq_name": "intraflagellar transport protein 56 isoform X1", "refseq_ac": [ { "id": "XP_002687045", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687045", "type": "external" } ], "gene_names_uniprotkb": "IFT56; TTC26; TTC26", "gene_names_refseq": "TTC26", "protein_names_uniprotkb": "Intraflagellar transport protein 56; Tetratricopeptide repeat protein 26", "protein_names_refseq": "intraflagellar transport protein 56 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:508011); (R-BTA-5620924)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0120170 intraciliary transport particle B binding", "go_cellular_component": "GO:0005929 cilium;GO:0005813 centrosome;GO:0036064 ciliary basal body;GO:0097546 ciliary base;GO:0030991 intraciliary transport particle A", "go_biological_process": "GO:0015031 protein transport;GO:0007224 smoothened signaling pathway;GO:0035735 intraciliary transport involved in cilium assembly;GO:0061512 protein localization to cilium;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MF33-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGI6-1", "uniprot_id": [ { "id": "F1MGI6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGI6", "type": "external" } ], "mass": 65441.0, "length": 588, "protein_name": "Tyrosine-protein kinase RYK", "gene_name": "RYK", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RYK", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase RYK; 2.7.10.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005109 frizzled binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane", "go_biological_process": "GO:0060071 Wnt signaling pathway, planar cell polarity pathway;GO:0043410 positive regulation of MAPK cascade;GO:0022038 corpus callosum development;GO:0036518 chemorepulsion of dopaminergic neuron axon;GO:1904948 midbrain dopaminergic neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGI6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MFB7-1", "uniprot_id": [ { "id": "F1MFB7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MFB7", "type": "external" } ], "mass": 57646.0, "length": 511, "protein_name": "4-aminobutyrate aminotransferase, mitochondrial", "gene_name": "ABAT", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ABAT", "gene_names_refseq": "", "protein_names_uniprotkb": "4-aminobutyrate aminotransferase, mitochondrial; (S)-3-amino-2-methylpropionate transaminase; 2.6.1.19; 2.6.1.22; GABA aminotransferase; Gamma-amino-N-butyrate transaminase; L-AIBAT", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-916853)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8J8YN34;M5FHM7", "ec_number_list": [ { "id": "2.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.19", "type": "external" }, { "id": "2.6.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.22", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0034386 4-aminobutyrate:2-oxoglutarate transaminase activity;GO:0047298 (S)-3-amino-2-methylpropionate transaminase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0032144 4-aminobutyrate transaminase complex", "go_biological_process": "GO:0009448 gamma-aminobutyric acid metabolic process;GO:0050877 nervous system process;GO:0009450 gamma-aminobutyric acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MFB7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHG1-1", "uniprot_id": [ { "id": "F1MHG1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHG1", "type": "external" } ], "mass": 76209.0, "length": 675, "protein_name": "Membrane-type matrix metalloproteinase 1", "gene_name": "MMP15", "organism": "Bovine", "refseq_name": "matrix metalloproteinase-15 precursor", "refseq_ac": [ { "id": "NP_001178363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178363", "type": "external" } ], "gene_names_uniprotkb": "MMP15", "gene_names_refseq": "MMP15", "protein_names_uniprotkb": "Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase", "protein_names_refseq": "matrix metallopeptidase 15 (membrane-inserted); matrix metalloproteinase 15 (membrane-inserted); matrix metalloproteinase-15 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:282887); (R-BTA-1442490); (R-BTA-1592389)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process;GO:0035987 endodermal cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHG1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MSD7-1", "uniprot_id": [ { "id": "F1MSD7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MSD7", "type": "external" } ], "mass": 136116.0, "length": 1194, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase", "gene_name": "PLCB4", "organism": "Bovine", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4", "refseq_ac": [ { "id": "NP_001159982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159982", "type": "external" } ], "gene_names_uniprotkb": "PLCB4", "gene_names_refseq": "PLCB4", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; 3.1.4.11", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; PCL-C1; PLC-beta-4; phosphoinositide phospholipase C-beta-4; phosphoinositide phospholipase C", "tax_id": 9913, "disease": "", "pathway": " (bta:281985); (R-BTA-112043); (R-BTA-1855204); (R-BTA-416476)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding;GO:0120548 phosphatidylinositol phospholipase C activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process;GO:0050804 modulation of chemical synaptic transmission;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MSD7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MX88-1", "uniprot_id": [ { "id": "F1MX88_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MX88", "type": "external" } ], "mass": 75042.0, "length": 679, "protein_name": "Solute carrier family 25 member 13", "gene_name": "SLC25A13", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC25A13", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 25 member 13", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8963693); (R-BTA-9856872)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange for L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation. Lacks transport activity towards gamma-aminobutyric acid (GABA)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005313 L-glutamate transmembrane transporter activity;GO:0015183 L-aspartate transmembrane transporter activity;GO:0042802 identical protein binding;GO:0000514 3-sulfino-L-alanine: proton, glutamate antiporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015810 aspartate transmembrane transport;GO:0015813 L-glutamate transmembrane transport;GO:0043490 malate-aspartate shuttle;GO:0051592 response to calcium ion;GO:0006754 ATP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MX88-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MNQ8-1", "uniprot_id": [ { "id": "F1MNQ8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MNQ8", "type": "external" } ], "mass": 36470.0, "length": 317, "protein_name": "Syntaxin 2", "gene_name": "STX2", "organism": "Bovine", "refseq_name": "syntaxin-2 isoform X1", "refseq_ac": [ { "id": "XP_010812170", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812170", "type": "external" } ], "gene_names_uniprotkb": "STX2", "gene_names_refseq": "STX2", "protein_names_uniprotkb": "Syntaxin 2", "protein_names_refseq": "syntaxin-2 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0031201 SNARE complex;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0048278 vesicle docking;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MNQ8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MG93-1", "uniprot_id": [ { "id": "F1MG93_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MG93", "type": "external" } ], "mass": 102040.0, "length": 958, "protein_name": "Chordin", "gene_name": "CHRD", "organism": "Bovine", "refseq_name": "chordin isoform X1", "refseq_ac": [ { "id": "XP_024851073", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851073", "type": "external" } ], "gene_names_uniprotkb": "CHRD", "gene_names_refseq": "CHRD", "protein_names_uniprotkb": "Chordin", "protein_names_refseq": "chordin isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:509942)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036122 BMP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0048731 system development;GO:0007389 pattern specification process;GO:0021513 spinal cord dorsal/ventral patterning;GO:0045785 positive regulation of cell adhesion;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MG93-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEW3-1", "uniprot_id": [ { "id": "F1MEW3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEW3", "type": "external" } ], "mass": 216540.0, "length": 2001, "protein_name": "Microtubule-associated protein", "gene_name": "MAP2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MAP2", "gene_names_refseq": "", "protein_names_uniprotkb": "Microtubule-associated protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0002162 dystroglycan binding;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005874 microtubule;GO:0043005 neuron projection;GO:0005829 cytosol", "go_biological_process": "GO:0031175 neuron projection development;GO:0000226 microtubule cytoskeleton organization;GO:0048813 dendrite morphogenesis;GO:0021954 central nervous system neuron development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEW3-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MMX5-1", "uniprot_id": [ { "id": "F1MMX5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MMX5", "type": "external" } ], "mass": 135521.0, "length": 1192, "protein_name": "Phospholipid-transporting ATPase", "gene_name": "ATP8B4", "organism": "Bovine", "refseq_name": "probable phospholipid-transporting ATPase IM isoform X1", "refseq_ac": [ { "id": "XP_002691019", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691019", "type": "external" } ], "gene_names_uniprotkb": "ATP8B4", "gene_names_refseq": "ATP8B4", "protein_names_uniprotkb": "Phospholipid-transporting ATPase; 7.6.2.1", "protein_names_refseq": "probable phospholipid-transporting ATPase IM isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:100137953); (R-BTA-6798695); (R-BTA-936837)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1MQK2", "ec_number_list": [ { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0012505 endomembrane system;GO:0005886 plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0015914 phospholipid transport;GO:0045332 phospholipid translocation;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MMX5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MU34-1", "uniprot_id": [ { "id": "F1MU34_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MU34", "type": "external" } ], "mass": 107064.0, "length": 942, "protein_name": "Aminopeptidase", "gene_name": "ERAP1", "organism": "Bovine", "refseq_name": "endoplasmic reticulum aminopeptidase 1 isoform X1", "refseq_ac": [ { "id": "XP_010805927", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805927", "type": "external" } ], "gene_names_uniprotkb": "ERAP1", "gene_names_refseq": "ERAP1", "protein_names_uniprotkb": "Aminopeptidase; 3.4.11.-", "protein_names_refseq": "endoplasmic reticulum aminopeptidase 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-983170)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" } ], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity;GO:0005138 interleukin-6 receptor binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0002250 adaptive immune response;GO:0006509 membrane protein ectodomain proteolysis;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MU34-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MNT4-1", "uniprot_id": [ { "id": "F1MNT4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MNT4", "type": "external" } ], "mass": 197415.0, "length": 1786, "protein_name": "Laminin subunit beta-1", "gene_name": "LAMB1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LAMB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Laminin subunit beta-1; Laminin B1 chain; Laminin-1 subunit beta; Laminin-10 subunit beta; Laminin-12 subunit beta; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin-8 subunit beta", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of the cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005606 laminin-1 complex;GO:0043259 laminin-10 complex;GO:0005615 extracellular space", "go_biological_process": "GO:0007155 cell adhesion;GO:0031175 neuron projection development;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MNT4-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQ31-1", "uniprot_id": [ { "id": "F1MQ31_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQ31", "type": "external" } ], "mass": 99526.0, "length": 912, "protein_name": "Brevican core protein", "gene_name": "BCAN", "organism": "Bovine", "refseq_name": "brevican core protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_776421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776421", "type": "external" } ], "gene_names_uniprotkb": "BCAN", "gene_names_refseq": "BCAN", "protein_names_uniprotkb": "Brevican core protein", "protein_names_refseq": "brevican core protein isoform 1 precursor; brevican core protein; chondroitin sulfate proteoglycan BEHAB/brevican", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1474228); (R-BTA-1971475); (R-BTA-2022870); (R-BTA-2022923); (R-BTA-2024101); (R-BTA-3000178)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0072534 perineuronal net;GO:0005615 extracellular space;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0060074 synapse maturation;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQ31-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHN8-1", "uniprot_id": [ { "id": "F1MHN8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHN8", "type": "external" } ], "mass": 64761.0, "length": 583, "protein_name": "CD166 antigen", "gene_name": "ALCAM", "organism": "Bovine", "refseq_name": "CD166 antigen isoform X1", "refseq_ac": [ { "id": "XP_059742006", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742006", "type": "external" } ], "gene_names_uniprotkb": "ALCAM", "gene_names_refseq": "ALCAM", "protein_names_uniprotkb": "CD166 antigen; Activated leukocyte cell adhesion molecule", "protein_names_refseq": "CD166 antigen isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0042101 T cell receptor complex;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007155 cell adhesion;GO:0002250 adaptive immune response;GO:0031175 neuron projection development;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHN8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MU32-1", "uniprot_id": [ { "id": "F1MU32_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MU32", "type": "external" } ], "mass": 60135.0, "length": 526, "protein_name": "Hexosyltransferase", "gene_name": "CSGALNACT1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CSGALNACT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2022870)", "pathway_count": 1, "publication_count": 0, 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"missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0015020 glucuronosyltransferase activity;GO:0008955 peptidoglycan glycosyltransferase activity;GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0019276 UDP-N-acetylgalactosamine metabolic process;GO:0046398 UDP-glucuronate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MU32-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MK24-1", "uniprot_id": [ { "id": "F1MK24_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MK24", "type": "external" } ], "mass": 86575.0, "length": 774, "protein_name": "Metal transporter", "gene_name": "CNNM4", "organism": "Bovine", "refseq_name": "metal transporter CNNM4 precursor", "refseq_ac": [ { "id": "NP_001192825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192825", "type": "external" } ], "gene_names_uniprotkb": "CNNM4", "gene_names_refseq": "CNNM4", "protein_names_uniprotkb": "Metal transporter", "protein_names_refseq": "cyclin M4; metal transporter CNNM4 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:522382)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Metal transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, 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"glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015081 sodium ion transmembrane transporter activity;GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0010960 magnesium ion homeostasis;GO:0015693 magnesium ion transport;GO:0030003 intracellular monoatomic cation homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MK24-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MMS0-1", "uniprot_id": [ { "id": "F1MMS0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MMS0", "type": "external" } ], "mass": 130898.0, "length": 1172, "protein_name": "DNA 5'-3' helicase", "gene_name": "BRIP1", "organism": "Bovine", "refseq_name": "Fanconi anemia group J protein", "refseq_ac": [ { "id": "XP_010814039", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814039", "type": "external" } ], "gene_names_uniprotkb": "BRIP1", "gene_names_refseq": "BRIP1", "protein_names_uniprotkb": "DNA 5'-3' helicase; 5.6.2.3; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein C-terminal helicase 1; DNA 5'-3' helicase FANCJ", "protein_names_refseq": "Fanconi anemia group J protein", "tax_id": 9913, "disease": "", "pathway": " (bta:783256); (R-BTA-5685938); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5693568); (R-BTA-5693579); (R-BTA-5693607); (R-BTA-5693616); (R-BTA-6804756); (R-BTA-69473)", "pathway_count": 10, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, 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"external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003678 DNA helicase activity;GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0005657 replication fork", "go_biological_process": "GO:0006139 nucleobase-containing compound metabolic process;GO:1990918 double-strand break repair involved in meiotic recombination;GO:0006289 nucleotide-excision repair;GO:0106300 protein-DNA covalent cross-linking repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MMS0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MJP2-1", "uniprot_id": [ { "id": "F1MJP2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MJP2", "type": "external" } ], "mass": 39627.0, "length": 347, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "ARK2C; RNF165", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ARK2C; RNF165; RNF165", "gene_names_refseq": "", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030513 positive regulation of BMP signaling pathway;GO:0008045 motor neuron axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MJP2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHR3-1", "uniprot_id": [ { "id": "F1MHR3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHR3", "type": "external" } ], "mass": 56184.0, "length": 512, "protein_name": "Aldehyde dehydrogenase 1A1", "gene_name": "ALDH1A3", "organism": "Bovine", "refseq_name": "retinaldehyde dehydrogenase 3", "refseq_ac": [ { "id": "XP_024838028", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838028", "type": "external" } ], "gene_names_uniprotkb": "ALDH1A3", "gene_names_refseq": "ALDH1A3", "protein_names_uniprotkb": "Aldehyde dehydrogenase 1A1; 1.2.1.19; 1.2.1.28; 1.2.1.36; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase family 1 member A3; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; Retinaldehyde dehydrogenase 3", "protein_names_refseq": "retinaldehyde dehydrogenase 3", "tax_id": 9913, "disease": "", "pathway": " (bta:507093); (R-BTA-5365859)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively. High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity. Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" } ], "go_molecular_function": "GO:0018479 benzaldehyde dehydrogenase (NAD+) activity;GO:0019145 aminobutyraldehyde dehydrogenase (NAD+) activity;GO:0042803 protein homodimerization activity;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030424 axon;GO:0005654 nucleoplasm", "go_biological_process": "GO:0043584 nose development;GO:0051289 protein homotetramerization;GO:0006081 aldehyde metabolic process;GO:0002138 retinoic acid biosynthetic process;GO:0031076 embryonic camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHR3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MVW5-1", "uniprot_id": [ { "id": "F1MVW5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MVW5", "type": "external" } ], "mass": 86185.0, "length": 765, "protein_name": "Protein transport protein SEC23", "gene_name": "SEC23A", "organism": "Bovine", "refseq_name": "protein transport protein Sec23A", "refseq_ac": [ { "id": "NP_001422014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422014", "type": "external" } ], "gene_names_uniprotkb": "SEC23A", "gene_names_refseq": "SEC23A", "protein_names_uniprotkb": "Protein transport protein SEC23", "protein_names_refseq": "SEC23-related protein A; Sec23 homolog A, coat complex II component; protein transport protein Sec23A", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-204005); (R-BTA-2132295); (R-BTA-5694530); (R-BTA-983170)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0030127 COPII vesicle coat;GO:0000139 Golgi membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0090114 COPII-coated vesicle budding;GO:0090110 COPII-coated vesicle cargo loading;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MVW5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MF78-1", "uniprot_id": [ { "id": "F1MF78_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MF78", "type": "external" } ], "mass": 797892.0, "length": 6920, "protein_name": "Nesprin-2", "gene_name": "SYNE2", "organism": "Bovine", "refseq_name": "nesprin-2 isoform X1", "refseq_ac": [ { "id": "XP_010807810", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807810", "type": "external" } ], "gene_names_uniprotkb": "SYNE2", "gene_names_refseq": "SYNE2", "protein_names_uniprotkb": "Nesprin-2; KASH domain-containing protein 2; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element protein; Synaptic nuclear envelope protein 2", "protein_names_refseq": "nesprin-2 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0140444 cytoskeleton-nuclear membrane anchor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030018 Z disc", "go_biological_process": "GO:0051642 centrosome localization;GO:0007097 nuclear migration;GO:0021817 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;GO:0031022 nuclear migration along microfilament;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MF78-1", "record_type": "protein", "filter_code": "0000000.0000000.000010.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MS24-1", "uniprot_id": [ { "id": "F1MS24_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MS24", "type": "external" } ], "mass": 73225.0, "length": 653, "protein_name": "Rab proteins geranylgeranyltransferase component A", "gene_name": "CHM", "organism": "Bovine", "refseq_name": "rab proteins geranylgeranyltransferase component A 1", "refseq_ac": [ { "id": "NP_001192318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192318", "type": "external" } ], "gene_names_uniprotkb": "CHM", "gene_names_refseq": "CHM", "protein_names_uniprotkb": "Rab proteins geranylgeranyltransferase component A", "protein_names_refseq": "CHM, Rab escort protein 1; rab proteins geranylgeranyltransferase component A 1", "tax_id": 9913, "disease": "", "pathway": " (bta:519552); (R-BTA-6803205); (R-BTA-8873719); (R-BTA-8876198)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005092 GDP-dissociation inhibitor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005968 Rab-protein geranylgeranyltransferase complex;GO:0005634 nucleus", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007264 small GTPase-mediated signal transduction;GO:0006612 protein targeting to membrane;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MS24-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MLP3-1", "uniprot_id": [ { "id": "F1MLP3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MLP3", "type": "external" } ], "mass": 35144.0, "length": 318, "protein_name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase", "gene_name": "BST1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "BST1", "gene_names_refseq": "", "protein_names_uniprotkb": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase; 3.2.2.6", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:616757); (R-BTA-163125); (R-BTA-196807); (R-BTA-6798695)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.11.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.9", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.4.50", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.50", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0016740 transferase activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating;GO:0016849 phosphorus-oxygen lyase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0001931 uropod", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0030890 positive regulation of B cell proliferation;GO:0050727 regulation of inflammatory response;GO:0001952 regulation of cell-matrix adhesion;GO:0050848 regulation of calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MLP3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true } ]