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AtVQ5", "protein_names_refseq": "VQ motif-containing protein-like protein", "tax_id": 3702, "disease": "", "pathway": " (ath:AT1G32585)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11130712;22535423;27862469", "class_list": "", "function": "May function as negative regulator of plant defense., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006952 defense response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3ED38-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.100000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8XCM7-1", "uniprot_id": [ { "id": "B8XCM7_9MONO", "url": "https://www.uniprot.org/uniprot/B8XCM7", "type": "external" } ], "mass": 82905.0, "length": 739, "protein_name": "Nucleoprotein", "gene_name": "NP", "organism": "Ebola (BDBV)", "refseq_name": "nucleoprotein", "refseq_ac": [ { "id": "YP_003815432", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_003815432", "type": "external" } ], "gene_names_uniprotkb": "NP", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleoprotein; 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VP35 binds to and stabilizes monomeric NP, keeping it soluble. Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. The nucleocapsid is helical with a pitch of 10.81 NP per turn and a diameter of about 22nm. Each NP binds to six nucleotides of viral genomic RNA, three being exposed to the solvant and three hidden into the nucleocapsid. Also recruits host PPP2R5C phosphatase to dephosphorylate VP30 and thereby promote viral transcription. 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"refseq_name": "polymerase complex protein", "refseq_ac": [ { "id": "YP_003815433", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_003815433", "type": "external" } ], "gene_names_uniprotkb": "VP35", "gene_names_refseq": "", "protein_names_uniprotkb": "Polymerase cofactor VP35", "protein_names_refseq": "polymerase complex protein", "tax_id": 565995, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0044423 virion component;GO:0030430 host cell cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0039722 symbiont-mediated suppression of host toll-like receptor signaling pathway;GO:0039723 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity;GO:0039557 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity;GO:0039724 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B8XCM8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000010000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8XCM9-1", "uniprot_id": [ { "id": "B8XCM9_9MONO", "url": "https://www.uniprot.org/uniprot/B8XCM9", "type": "external" } ], "mass": 35458.0, "length": 326, "protein_name": "Matrix protein VP40", "gene_name": "VP40", "organism": "Ebola (BDBV)", "refseq_name": "matrix protein", "refseq_ac": [ { "id": "YP_003815434", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_003815434", "type": "external" } ], "gene_names_uniprotkb": "VP40", "gene_names_refseq": "", "protein_names_uniprotkb": "Matrix protein VP40; Membrane-associated protein VP40", "protein_names_refseq": "matrix protein", "tax_id": 565995, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an essential role virus particle assembly and budding. Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101. The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding. May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis)., [UniProtKB, UniProtKB]; Plays an essential role virus particle assembly and budding. Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0039660 structural constituent of virion", "go_cellular_component": "GO:1990904 ribonucleoprotein complex;GO:0055036 virion membrane;GO:0020002 host cell plasma membrane;GO:0033645 host cell endomembrane system;GO:0044185 host cell late endosome membrane", "go_biological_process": "GO:0039702 viral budding via host ESCRT complex;GO:0052170 symbiont-mediated suppression of host innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B8XCM9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000010000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8XCN0-1", "uniprot_id": [ { "id": "B8XCN0_9MONO", "url": "https://www.uniprot.org/uniprot/B8XCN0", "type": "external" } ], "mass": 75689.0, "length": 676, "protein_name": "Envelope glycoprotein", "gene_name": "GP", "organism": "Ebola (BDBV)", "refseq_name": "spike glycoprotein", "refseq_ac": [ { "id": "YP_003815435", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_003815435", "type": "external" } ], "gene_names_uniprotkb": "GP", "gene_names_refseq": "", "protein_names_uniprotkb": "Envelope glycoprotein; GP1,2", "protein_names_refseq": "spike glycoprotein", "tax_id": 565995, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "35927436;26806128;30184505;30206174;30996276;33852862", "class_list": "", "function": "Acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in GP2, releasing the fusion hydrophobic peptide., [UniProtKB, UniProtKB]; Functions as a decoy for anti-GP1,2 antibodies thereby contributing to viral immune evasion. Interacts and activates host macrophages and dendritic cells inducing up-regulation of cytokine transcription. This effect is mediated throught activation of host TLR4., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 10, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 8424, "biomarker_type": "", "glycan_count": 91, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019031 viral envelope;GO:0055036 virion membrane;GO:0020002 host cell plasma membrane", "go_biological_process": "GO:0039587 symbiont-mediated-mediated suppression of host tetherin activity;GO:0039654 fusion of virus membrane with host endosome membrane;GO:0075512 clathrin-dependent endocytosis of virus by host cell;GO:0098670 entry receptor-mediated virion attachment to host cell;GO:0052170 symbiont-mediated suppression of host innate immune response", "synthesized_glycan_count": 0, "hit_score": 10.8, "record_id": "B8XCN0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000010000000000000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8XCN1-1", "uniprot_id": [ { "id": "B8XCN1_9MONO", "url": "https://www.uniprot.org/uniprot/B8XCN1", "type": "external" } ], "mass": 42471.0, "length": 373, "protein_name": "", "gene_name": "GP", "organism": "Ebola (BDBV)", "refseq_name": "small secreted glycoprotein", "refseq_ac": [ { "id": "YP_003815436", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_003815436", "type": "external" } ], "gene_names_uniprotkb": "GP", "gene_names_refseq": "", "protein_names_uniprotkb": "", "protein_names_refseq": "small secreted glycoprotein", "tax_id": 565995, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B8XCN1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000010000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8XCN3-1", "uniprot_id": [ { "id": "B8XCN3_9MONO", "url": "https://www.uniprot.org/uniprot/B8XCN3", "type": "external" } ], "mass": 32839.0, "length": 289, "protein_name": "Transcriptional activator VP30", "gene_name": "VP30", "organism": "Ebola (BDBV)", "refseq_name": "minor nucleoprotein", "refseq_ac": [ { "id": "YP_003815438", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_003815438", "type": "external" } ], "gene_names_uniprotkb": "VP30", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcriptional activator VP30; Minor nucleoprotein VP30", "protein_names_refseq": "minor nucleoprotein", "tax_id": 565995, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA. Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Also assists stop-start transcription at gene junctions to promote transcription of downstream genes. Interaction with NP plays a critical role in transcription initiation by recognizing the RNA stem loop. Interaction with host RBBP6 interferes with NP-VP30 interaction and inhibits viral RNA synthesis. Also acts as a suppressor of RNA silencing by interacting with host DICER1 and TARBP2/TRBP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0019013 viral nucleocapsid;GO:0030430 host cell cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B8XCN3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000010000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8XCN4-1", "uniprot_id": [ { "id": "B8XCN4_9MONO", "url": "https://www.uniprot.org/uniprot/B8XCN4", "type": "external" } ], "mass": 28164.0, "length": 251, "protein_name": "Membrane-associated protein VP24", "gene_name": "VP24", "organism": "Ebola (BDBV)", "refseq_name": "membrane-associated protein", "refseq_ac": [ { "id": "YP_003815439", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_003815439", "type": "external" } ], "gene_names_uniprotkb": "VP24", "gene_names_refseq": "", "protein_names_uniprotkb": "Membrane-associated protein VP24", "protein_names_refseq": "membrane-associated protein", "tax_id": 565995, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0016020 membrane;GO:0055036 virion membrane;GO:0020002 host cell plasma membrane", "go_biological_process": "GO:0016032 viral process;GO:0052031 symbiont-mediated perturbation of host defense response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B8XCN4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000010000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8XCN5-1", "uniprot_id": [ { "id": "B8XCN5_9MONO", "url": "https://www.uniprot.org/uniprot/B8XCN5", "type": "external" } ], "mass": 251649.0, "length": 2210, "protein_name": "RNA-directed RNA polymerase L", "gene_name": "L", "organism": "Ebola (BDBV)", "refseq_name": "RNA-dependent RNA polymerase", "refseq_ac": [ { "id": "YP_003815440", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_003815440", "type": "external" } ], "gene_names_uniprotkb": "L", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA-directed RNA polymerase L; Large structural protein; PRNTase; Protein L; Replicase; Transcriptase", "protein_names_refseq": "RNA-dependent RNA polymerase", "tax_id": 565995, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003968 RNA-directed RNA polymerase activity;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity", "go_cellular_component": "GO:0044423 virion component;GO:0030430 host cell cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B8XCN5-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000010000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10894-1", "uniprot_id": [ { "id": "PLCB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P10894", "type": "external" } ], "mass": 138715.0, "length": 1216, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1", "gene_name": "PLCB1", "organism": "Bovine", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1", "refseq_ac": [ { "id": "NP_777242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777242", "type": "external" } ], "gene_names_uniprotkb": "PLCB1", "gene_names_refseq": "PLCB1", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; 3.1.4.11; PLC-154; PLC-beta-1; Phosphoinositide phospholipase C-beta-1; Phospholipase C-beta-1", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; PLC-154; PLC-I; PLC-beta-1; phosphoinositide phospholipase C-beta-1; phosphoinositide phospholipase C; phospholipase C, beta 1 (phosphoinositide-specific)", "tax_id": 9913, "disease": "", "pathway": " (bta:287026); (R-BTA-112043); (R-BTA-1855204); (R-BTA-399997); (R-BTA-4086398); (R-BTA-416476); (R-BTA-418217); (R-BTA-434316); (R-BTA-500657)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "2211670;2455601;34129193", "class_list": "", "function": "Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Investigation of high correlation with carcass traits of SNPs of the PLCB1, C/EBPalpha, and TDRKH genes and the combinations of SNPs using the MDR method in the Hanwoo., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005096 GTPase activator activity;GO:0005516 calmodulin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0031965 nuclear membrane;GO:0016020 membrane", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007613 memory;GO:0046330 positive regulation of JNK cascade;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P10894-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MKF1-1", "uniprot_id": [ { "id": "THTPA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8MKF1", "type": "external" } ], "mass": 23983.0, "length": 219, "protein_name": "Thiamine-triphosphatase", "gene_name": "THTPA", "organism": "Bovine", "refseq_name": "thiamine-triphosphatase", "refseq_ac": [ { "id": "NP_776895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776895", "type": "external" } ], "gene_names_uniprotkb": "THTPA", "gene_names_refseq": "THTPA", "protein_names_uniprotkb": "Thiamine-triphosphatase; 3.6.1.28; ThTPase", "protein_names_refseq": "thTPase; thiamine-triphosphatase", "tax_id": 9913, "disease": "", "pathway": " (bta:282090); (R-BTA-196819)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11827967", "class_list": "", "function": "Hydrolase highly specific for thiamine triphosphate (ThTP)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KJ88", "ec_number_list": [ { "id": "3.6.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.28", "type": "external" } ], "go_molecular_function": "GO:0050333 thiamine triphosphate phosphatase activity;GO:0000287 magnesium ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042357 thiamine diphosphate metabolic process;GO:0006772 thiamine metabolic process;GO:0009229 thiamine diphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8MKF1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58CU2-1", "uniprot_id": [ { "id": "E41L5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q58CU2", "type": "external" } ], "mass": 57169.0, "length": 502, "protein_name": "Band 4.1-like protein 5", "gene_name": "EPB41L5", "organism": "Bovine", "refseq_name": "band 4.1-like protein 5 isoform 3", "refseq_ac": [ { "id": "NP_001030461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030461", "type": "external" } ], "gene_names_uniprotkb": "EPB41L5", "gene_names_refseq": "EPB41L5", "protein_names_uniprotkb": "Band 4.1-like protein 5; Erythrocyte membrane protein band 4.1-like 5", "protein_names_refseq": "band 4.1-like protein 5 isoform 3; band 4.1-like protein 5", "tax_id": 9913, "disease": "", "pathway": " (bta:530941); (R-BTA-6794361)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16305752;17920587", "class_list": "", "function": "Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008092 cytoskeletal protein binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0031032 actomyosin structure organization;GO:0001837 epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q58CU2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB62-1", "uniprot_id": [ { "id": "ARP2_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB62", "type": "external" } ], "mass": 44761.0, "length": 394, "protein_name": "Actin-related protein 2", "gene_name": "ACTR2", "organism": "Bovine", "refseq_name": "actin-related protein 2", "refseq_ac": [ { "id": "NP_001095683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095683", "type": "external" } ], "gene_names_uniprotkb": "ACTR2; ARP2", "gene_names_refseq": "ACTR2; ARP2", "protein_names_uniprotkb": "Actin-related protein 2; Actin-like protein 2", "protein_names_refseq": "ARP2 actin related protein 2 homolog; actin-like protein 2; actin-related protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:538486); (R-BTA-2029482); (R-BTA-3928662); (R-BTA-5663213); (R-BTA-6798695); (R-BTA-8856828)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "11721045;12176354;14757065;15117967;15505213;15592479;17251352;17499050;23893131;26323303;26598519", "class_list": "", "function": "ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Conserved surface residues to search for functionally important structural elements, [RefSeq, PubMed]; Crystal structure of Arp2/3 complex, [RefSeq, PubMed]; Data show that L. monocytogenes motility can be separated into an Arp2/3-dependent nucleation phase, and an Arp2/3-independent elongation phase which is dependent upon fascin., [RefSeq, PubMed]; Domain rearrangements of Arp2 and Arp3 result in a closed conformational state consistent with an 'actin-dimer' model for the active state, [RefSeq, PubMed]; Interacts with contactin and N-WASp, [RefSeq, PubMed]; The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin., [RefSeq, PubMed]; These results demonstrate an important role for CRMP-1 in Listeria actin comet tail formation and open the possibility that CRMP-1 controls cell motility by modulating Arp2/3 activation., [RefSeq, PubMed]; WASp stabilizes p35-dependent closure of the complex, holding Arp2 and Arp3 closer together to nucleate an actin filament., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0035861 site of double-strand break", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0010592 positive regulation of lamellipodium assembly;GO:1905168 positive regulation of double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A7MB62-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7SIB2-1", "uniprot_id": [ { "id": "CO4A1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q7SIB2", "type": "external" } ], "mass": 160412.0, "length": 1669, "protein_name": "Collagen alpha-1(IV) chain", "gene_name": "COL4A1", "organism": "Bovine", "refseq_name": "collagen alpha-1(IV) chain precursor", "refseq_ac": [ { "id": "NP_001159983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159983", "type": "external" } ], "gene_names_uniprotkb": "COL4A1", "gene_names_refseq": "COL4A1", "protein_names_uniprotkb": "Collagen alpha-1(IV) chain", "protein_names_refseq": "collagen alpha-1(IV) chain precursor; collagen alpha-1(IV) chain; collagen, type IV, alpha 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282191); (R-BTA-1442490); (R-BTA-1566977); (R-BTA-1650814); (R-BTA-186797); (R-BTA-2022090); (R-BTA-216083); (R-BTA-2243919); (R-BTA-3000171)", "pathway_count": 9, "publication_count": 8, "publication_id_list": "11970952;15299013;19393038;19729652;1990011;20490867;24368846;6430279", "class_list": "", "function": "Alpha1.alpha2 stabilize the noncollagenous domain-1 by noncovalent forces and the absence of Met-Lys cross-links, [RefSeq, PubMed]; Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation., [UniProtKB, UniProtKB]; High shear stress up-regulates type IV collagen synthesis and down-regulates MMP-2 secretion in endothelial cells., [RefSeq, PubMed]; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 0, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 20, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 35, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "G1K238", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0005201 extracellular matrix structural constituent;GO:0048407 platelet-derived growth factor binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005587 collagen type IV trimer;GO:0005604 basement membrane;GO:0005581 collagen trimer", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization;GO:0007420 brain development;GO:0001569 branching involved in blood vessel morphogenesis;GO:0061304 retinal blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "Q7SIB2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42891-1", "uniprot_id": [ { "id": "ECE1_BOVIN", "url": "https://www.uniprot.org/uniprot/P42891", "type": "external" } ], "mass": 85517.0, "length": 754, "protein_name": "Endothelin-converting enzyme 1", "gene_name": "ECE1", "organism": "Bovine", "refseq_name": "endothelin-converting enzyme 1 isoform X2", "refseq_ac": [ { "id": "XP_005203129", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203129", "type": "external" } ], "gene_names_uniprotkb": "ECE1", "gene_names_refseq": "ECE1", "protein_names_uniprotkb": "Endothelin-converting enzyme 1; 3.4.24.71; ECE-1", "protein_names_refseq": "endothelin-converting enzyme 1 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-375276)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26806547;7805846", "class_list": "", "function": "Converts big endothelin-1 to endothelin-1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A2VDM9", "ec_number_list": [ { "id": "3.4.24.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.71", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005768 endosome;GO:0048471 perinuclear region of cytoplasm;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0016486 peptide hormone processing;GO:0071526 semaphorin-plexin signaling pathway;GO:0001921 positive regulation of receptor recycling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P42891-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95107-1", "uniprot_id": [ { "id": "WASL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q95107", "type": "external" } ], "mass": 54672.0, "length": 505, "protein_name": "Actin nucleation-promoting factor WASL", "gene_name": "WASL", "organism": "Bovine", "refseq_name": "actin nucleation-promoting factor WASL", "refseq_ac": [ { "id": "NP_776644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776644", "type": "external" } ], "gene_names_uniprotkb": "WASL", "gene_names_refseq": "WASL", "protein_names_uniprotkb": "Actin nucleation-promoting factor WASL; N-WASP; Neural Wiskott-Aldrich syndrome protein", "protein_names_refseq": "N-WASP; Wiskott-Aldrich syndrome like; actin nucleation-promoting factor WASL; neural Wiskott-Aldrich syndrome protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281577); (R-BTA-2029482); (R-BTA-203641); (R-BTA-373753); (R-BTA-3928662); (R-BTA-418885); (R-BTA-5663213); (R-BTA-8856828); (R-BTA-9013406); (R-BTA-9013424)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "17609109;24227886;8895577", "class_list": "", "function": "N-WASP WWCA domains can processively attach to growing barbed-end bundles and increase their diffusion-limited elongation rate., [RefSeq, PubMed]; Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:17609109). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0005789 endoplasmic reticulum membrane;GO:0098978 glutamatergic synapse;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0030036 actin cytoskeleton organization;GO:0030041 actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q95107-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28115-1", "uniprot_id": [ { "id": "GFAP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28115", "type": "external" } ], "mass": 49512.0, "length": 428, "protein_name": "Glial fibrillary acidic protein", "gene_name": "GFAP", "organism": "Bovine", "refseq_name": "glial fibrillary acidic protein", "refseq_ac": [ { "id": "NP_776490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776490", "type": "external" } ], "gene_names_uniprotkb": "GFAP", "gene_names_refseq": "GFAP", "protein_names_uniprotkb": "Glial fibrillary acidic protein; GFAP", "protein_names_refseq": "glial fibrillary acidic protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281189)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10571109;8010535", "class_list": "", "function": "GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5L4;Q866S9", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005882 intermediate filament;GO:0042995 cell projection;GO:0016020 membrane;GO:0044297 cell body", "go_biological_process": "GO:0045109 intermediate filament organization;GO:1904714 regulation of chaperone-mediated autophagy;GO:0048484 enteric nervous system development;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28115-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q863C3-1", "uniprot_id": [ { "id": "GRP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q863C3", "type": "external" } ], "mass": 14934.0, "length": 134, "protein_name": "Gastrin-releasing peptide", "gene_name": "GRP", "organism": "Bovine", "refseq_name": "gastrin-releasing peptide precursor", "refseq_ac": [ { "id": "NP_001094709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094709", "type": "external" } ], "gene_names_uniprotkb": "GRP", "gene_names_refseq": "GRP", "protein_names_uniprotkb": "Gastrin-releasing peptide; GRP-(18-27); GRP-10; GRP18-27; GRP", "protein_names_refseq": "gastrin-releasing peptide precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:615323); (R-BTA-375276); (R-BTA-381771); (R-BTA-416476)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "14692689;14997389;15007209;2755876", "class_list": "", "function": "GRP may be important both in the development of the fetal cervix and secretory activity of the epithelial cells of the cervix., [RefSeq, PubMed]; GRP may be important both in the endometrial remodeling during the estrous cycle and in the implantation and development of blastocysts, [RefSeq, PubMed]; Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake (By similarity). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The present results revealed the localization of GRP in the uterine gland cells at light- and electron-microscopic levels and suggested the release of GRP from the cell into the lumen of the gland by exocrine manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QQP2;Q7M2Y8", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034774 secretory granule lumen;GO:0043005 neuron projection;GO:0005576 extracellular region;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0051970 negative regulation of transmission of nerve impulse;GO:0007218 neuropeptide signaling pathway;GO:0048565 digestive tract development;GO:2000987 positive regulation of behavioral fear response;GO:0090277 positive regulation of peptide hormone secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q863C3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZX0-1", "uniprot_id": [ { "id": "PLM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZX0", "type": "external" } ], "mass": 10447.0, "length": 92, "protein_name": "Phospholemman", "gene_name": "FXYD1", "organism": "Bovine", "refseq_name": "phospholemman precursor", "refseq_ac": [ { "id": "NP_001069878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069878", "type": "external" } ], "gene_names_uniprotkb": "FXYD1; PLM", "gene_names_refseq": "FXYD1", "protein_names_uniprotkb": "Phospholemman; FXYD domain-containing ion transport regulator 1; Sodium/potassium-transporting ATPase subunit FXYD1", "protein_names_refseq": "phospholemman precursor; phospholemman; sodium/potassium-transporting ATPase subunit FXYD1", "tax_id": 9913, "disease": "", "pathway": " (bta:616139); (R-BTA-5578775); (R-BTA-936837)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12657675;25051342", "class_list": "", "function": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:12657675). Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (By similarity). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (By similarity). Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; The evolutionary conservation of G-quadruplex forming sequences with the confirmation of G-quadruplex formation in vitro by two FXYD1 homologues, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0099106 ion channel regulator activity", "go_cellular_component": "GO:0014704 intercalated disc;GO:0016324 apical plasma membrane;GO:0005901 caveola;GO:0042383 sarcolemma;GO:0030315 T-tubule", "go_biological_process": "GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:1903278 positive regulation of sodium ion export across plasma membrane;GO:0010734 negative regulation of protein glutathionylation;GO:0086036 regulation of cardiac muscle cell membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3SZX0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48018-1", "uniprot_id": [ { "id": "SYT1_BOVIN", "url": "https://www.uniprot.org/uniprot/P48018", "type": "external" } ], "mass": 47623.0, "length": 422, "protein_name": "Synaptotagmin-1", "gene_name": "SYT1", "organism": "Bovine", "refseq_name": "synaptotagmin-1", "refseq_ac": [ { "id": "NP_776617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776617", "type": "external" } ], "gene_names_uniprotkb": "SYT1", "gene_names_refseq": "SYT1", "protein_names_uniprotkb": "Synaptotagmin-1; Synaptotagmin I; SytI; p65", "protein_names_refseq": "p65; synaptotagmin I; synaptotagmin-1; sytI", "tax_id": 9913, "disease": "", "pathway": " (bta:281511); (R-BTA-181429); (R-BTA-181430); (R-BTA-210500); (R-BTA-212676); (R-BTA-264642); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-888590)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "12496268;1719959;8454654", "class_list": "", "function": "Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB, UniProtKB]; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone., [UniProtKB, UniProtKB, UniProtKB]; This protein binds to target SNAREs in synaptic vesicle exocytosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030136 clathrin-coated vesicle;GO:0030672 synaptic vesicle membrane;GO:0070382 exocytic vesicle", "go_biological_process": "GO:0030154 cell differentiation;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:2000300 regulation of synaptic vesicle exocytosis;GO:1903235 positive regulation of calcium ion-dependent exocytosis of neurotransmitter", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P48018-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00829-1", "uniprot_id": [ { "id": "ATPB_BOVIN", "url": "https://www.uniprot.org/uniprot/P00829", "type": "external" } ], "mass": 56284.0, "length": 528, "protein_name": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial", "gene_name": "ATP5F1B", "organism": "Bovine", "refseq_name": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial precursor", "refseq_ac": [ { "id": "NP_786990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786990", "type": "external" } ], "gene_names_uniprotkb": "ATP5F1B; ATP5B", "gene_names_refseq": "ATP5B; ATP5F1B", "protein_names_uniprotkb": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial; 7.1.2.2; ATP synthase F1 subunit beta", "protein_names_refseq": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial precursor; ATP synthase F(1) complex catalytic subunit beta, mitochondrial; ATP synthase subunit beta, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide; F1-ATPase beta-subunit; mitochondrial ATP synthase beta subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:327675); (R-BTA-1268020); (R-BTA-163210); (R-BTA-8949613); (R-BTA-9837999)", "pathway_count": 5, "publication_count": 26, "publication_id_list": "12923572;14633978;17570365;17895376;1827992;1833193;19801635;21452901;22733764;23407638;2458129;24798048;25681765;25851905;26439008;28100784;2864455;2896550;2898218;41018975;6223927;6298222;8065448;8790345;95168;9687365", "class_list": "", "function": "Analysis of a new catalytic intermediate in the pathway of ATP hydrolysis by F1-ATPase from bovine heart mitochondria, [RefSeq, PubMed]; Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Combining cryoelectron microscopy data with bioinformatic analysis allowed the authors to determine the fold of the a subunit, suggesting a proton translocation path through the FO region that involves both the a and b subunits. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular dynamics simulations of F1-ATPase suggest that the equilibrium conformation of a nucleotide-free beta-subunit is the open conformation and that the transition from the closed to the open conformation can occur in a few tens of nanoseconds., [RefSeq, PubMed]; Molecular dynamics simulations show that the nucleotide-free beta subunit, initially in the open, low-affinity state, undergoes a spontaneous closing transition to the half-open state in response to the gamma rotation in the synthesis direction., [RefSeq, PubMed]; Produces ATP from ADP in the presence of a proton gradient across the membrane., [UniProtKB, UniProtKB]; These data indicate that interaction with the alpha-phosphate is not crucial for efficient catalysis, but likely contributes to avoid formation of ADP-inhibited intermediates., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1JQA9;Q9T2U4;Q9T2U5", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism;GO:0043532 angiostatin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0001525 angiogenesis;GO:0043536 positive regulation of blood vessel endothelial cell migration;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P00829-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9TUI9-1", "uniprot_id": [ { "id": "APEL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9TUI9", "type": "external" } ], "mass": 8743.0, "length": 77, "protein_name": "Apelin", "gene_name": "APLN", "organism": "Bovine", "refseq_name": "apelin precursor", "refseq_ac": [ { "id": "NP_776928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776928", "type": "external" } ], "gene_names_uniprotkb": "APLN; APEL", "gene_names_refseq": "APLN", "protein_names_uniprotkb": "Apelin; APJ endogenous ligand", "protein_names_refseq": "APJ endogenous ligand; apelin precursor; apelin, AGTRL1 ligand; apelin; peptide ligand for APJ receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:282143); (R-BTA-375276); (R-BTA-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10525157;19223129;19461937;31326705;9792798", "class_list": "", "function": "APJ receptor in granulosa cells and both apelin and the APJ receptor in theca tissues are expressed in bovine ovary., [RefSeq, PubMed]; Peptide hormone that functions as endogenous ligand for the G protein-coupled apelin receptor (APLNR/APJ), that plays a role in cadiovascular homeostasis (PubMed:9792798). Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR. Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs. On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor. Apelin blunts cardiac hypertrophic induction from APLNR on response to pathological stimuli, but also induces myocardial hypertrophy under normal conditions (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The data suggest that apelin/APJ system is involved in the mechanism regulating angiogenesis during follicle maturation as well as during corpora lutea formation and function in the bovine ovary. Publication Status: Online-Only, [RefSeq, PubMed]; These results showed that serum Apelin-36 concentration decreased after parturition in dairy cow; alteration of Apelin-36 secretion after parturition may represent an endocrine adaptation in dairy cow during the lactating period., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0031704 apelin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0001525 angiogenesis;GO:0010629 negative regulation of gene expression;GO:1904022 positive regulation of G protein-coupled receptor internalization;GO:0045776 negative regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9TUI9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3Y5Z3-1", "uniprot_id": [ { "id": "ADIPO_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3Y5Z3", "type": "external" } ], "mass": 26133.0, "length": 240, "protein_name": "Adiponectin", "gene_name": "ADIPOQ", "organism": "Bovine", "refseq_name": "adiponectin precursor", "refseq_ac": [ { "id": "NP_777167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777167", "type": "external" } ], "gene_names_uniprotkb": "ADIPOQ; ACRP30; APM1", "gene_names_refseq": "ACRP30; ADID; ADIPOQ; APM1", "protein_names_uniprotkb": "Adiponectin; 30 kDa adipocyte complement-related protein; ACRP30; Adipocyte complement-related 30 kDa protein; Adipocyte, C1q and collagen domain-containing protein; Adipose most abundant gene transcript 1 protein; apM-1", "protein_names_refseq": "30 kDa adipocyte complement-related protein; adipocyte complement related 30kDa protein; adipocyte complement related protein of 30 kDa; adipocyte complement-related 30 kDa protein; adipocyte, C1q and collagen domain-containing protein; adiponectin D; adiponectin precursor; adipose most abundant gene transcript 1 protein; apM-1", "tax_id": 9913, "disease": "", "pathway": " (bta:282865)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11382781;14551684;15378692;18446445;24462180;25676879;25817801;28843695", "class_list": "", "function": "A 5bp deletion mutation within the bovine ACRP30 gene was firstly detected and confirmed in 991 cattle ., [RefSeq, PubMed]; Data suggest that genetic variation in promoter region of ADIPOQ (SNPs g.81966235C>T, g.81966377T>C, and g.81966364D>I) contribute to adiposity/marbling in skeletal muscle/meat (and thus meat quality) of Hanwoo beef cattle of North Korea., [RefSeq, PubMed]; Gobular adiponectin increased NO production in aortic endothlium by increasing NO synthase activity., [RefSeq, PubMed]; Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW (By similarity)., [UniProtKB]; Low level expression of adiponectin mRNA was found in all areas of bovine mammary gland tissues examined. AdipoR1 and AdipoR2 mRNAs were also detected in mammary tissues and their expression was particularly prominent in the parenchyma and cistern., [RefSeq, PubMed]; These data suggest differential contribution of adipose tissue depots to circulating adiponectin., [RefSeq, PubMed]; These data suggest that energy balance around parturition may regulate plasma adiponectin but do not support roles for lipid mobilization or sustained changes in the plasma concentration of leptin, insulin, growth hormone, or fatty acids., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 5, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A5D7A8;Q95MQ4", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0005179 hormone activity;GO:0033691 sialic acid binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm;GO:0071944 cell periphery", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0010875 positive regulation of cholesterol efflux;GO:0032869 cellular response to insulin stimulus;GO:0034612 response to tumor necrosis factor;GO:0050873 brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3Y5Z3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95N27-1", "uniprot_id": [ { "id": "PP16B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q95N27", "type": "external" } ], "mass": 63643.0, "length": 568, "protein_name": "Protein phosphatase 1 regulatory inhibitor subunit 16B", "gene_name": "PPP1R16B", "organism": "Bovine", "refseq_name": "protein phosphatase 1 regulatory inhibitor subunit 16B", "refseq_ac": [ { "id": "NP_777249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777249", "type": "external" } ], "gene_names_uniprotkb": "PPP1R16B", "gene_names_refseq": "PPP1R16B; TIMAP", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory inhibitor subunit 16B; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; bTIMAP", "protein_names_refseq": "CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; bTIMAP; protein phosphatase 1 regulatory inhibitor subunit 16B; protein phosphatase 1, regulatory (inhibitor) subunit 16B", "tax_id": 9913, "disease": "", "pathway": " (bta:282091)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12055102;17609201;21907835;23685145;26806547", "class_list": "", "function": "Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of the PI3K/AKT signaling pathway (By similarity). Involved in the regulation of angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (PubMed:26806547). Involved in the regulation of endothelial cell filopodia extension (PubMed:17609201). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (By similarity). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (By similarity). Involved in the dephosphorylation of EEF1A1 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; TIMAP can modify protein phosphorylation independent of its function as a PP1c regulatory subunit, namely by masking phosphorylation sites of binding partners like PP1c and LAMR1., [RefSeq, PubMed]; TIMAP is a target for PKA-primed GSK-3beta-mediated phosphorylation. This phosphorylation controls TIMAP association and activity of PP1c, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004857 enzyme inhibitor activity;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0061028 establishment of endothelial barrier;GO:0051489 regulation of filopodium assembly;GO:1903670 regulation of sprouting angiogenesis;GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q95N27-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MAZ5-1", "uniprot_id": [ { "id": "H13_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MAZ5", "type": "external" } ], "mass": 22154.0, "length": 221, "protein_name": "Histone H1.3", "gene_name": "H1-3", "organism": "Bovine", "refseq_name": "histone H1.3", "refseq_ac": [ { "id": "NP_001094536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094536", "type": "external" } ], "gene_names_uniprotkb": "H1-3", "gene_names_refseq": "H1-3; HIST1H1D", "protein_names_uniprotkb": "Histone H1.3", "protein_names_refseq": "histone H1.3; histone cluster 1, H1d", "tax_id": 9913, "disease": "", "pathway": " (bta:509275)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19393038;3134256", "class_list": "", "function": "Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000791 euchromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination;GO:0048024 regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A7MAZ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7R9-1", "uniprot_id": [ { "id": "PRCD_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7R9", "type": "external" } ], "mass": 5995.0, "length": 54, "protein_name": "Photoreceptor disk component PRCD", "gene_name": "PRCD", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PRCD", "gene_names_refseq": "", "protein_names_uniprotkb": "Photoreceptor disk component PRCD; Progressive rod-cone degeneration protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "19393038;23672200;27509380", "class_list": "", "function": "Involved in vision., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002046 opsin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0050908 detection of light stimulus involved in visual perception", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E1B7R9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZBF6-1", "uniprot_id": [ { "id": "ACADS_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3ZBF6", "type": "external" } ], "mass": 44552.0, "length": 412, "protein_name": "Short-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "ACADS", "organism": "Bovine", "refseq_name": "short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001029573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029573", "type": "external" } ], "gene_names_uniprotkb": "ACADS", "gene_names_refseq": "ACADS", "protein_names_uniprotkb": "Short-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.1; Butyryl-CoA dehydrogenase; SCAD", "protein_names_refseq": "SCAD; acyl-CoA dehydrogenase, C-2 to C-3 short chain; acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain; butyryl-CoA dehydrogenase; short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor; short-chain specific acyl-CoA dehydrogenase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:511222)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "6712627", "class_list": "", "function": "Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:6712627)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.4", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0050660 flavin adenine dinucleotide binding;GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0046359 butyrate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3ZBF6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5E9F8-1", "uniprot_id": [ { "id": "H33_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5E9F8", "type": "external" } ], "mass": 15328.0, "length": 136, "protein_name": "Histone H3.3", "gene_name": "H3-3A; H3-3B", "organism": "Bovine", "refseq_name": "histone H3.3", "refseq_ac": [ { "id": "NP_001014411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014411", "type": "external" } ], "gene_names_uniprotkb": "H3-3A; H3-3B; H3F3A; H3F3B", "gene_names_refseq": "H3-3A; H3-3B; H3F3A", "protein_names_uniprotkb": "Histone H3.3", "protein_names_refseq": "H3 histone, family 3A; histone H3.3", "tax_id": 9913, "disease": "", "pathway": " (bta:326601); (bta:617051); (R-BTA-201722); (R-BTA-212300); (R-BTA-2299718); (R-BTA-2559580); (R-BTA-2559582); (R-BTA-427359); (R-BTA-427413); (R-BTA-5250924); (R-BTA-5578749); (R-BTA-5625886); (R-BTA-68616); (R-BTA-73728); (R-BTA-73772); (R-BTA-8936459); (R-BTA-9018519); (R-BTA-9670095); (R-BTA-9764725); (R-BTA-983231); (R-BTA-9841922); (R-BTA-9843940); (R-BTA-9843970); (R-BTA-9909649); (R-BTA-9940951); (R-BTA-9943411); (R-BTA-9943962); (R-BTA-9970672)", "pathway_count": 28, "publication_count": 4, "publication_id_list": "10464286;12658628;16305752;29232016", "class_list": "", "function": "H3F3A mRNA abundance is stable whereas H3F3B and HIRA mRNA are relatively dynamic during early embryonic development. H3F3B mRNA quantity is also considerably higher than H3F3A. Immunofluorescence analysis revealed an even distribution of H3.3 between paternal and maternal pronuclei in zygotes, and subsequent stage-specific localization of H3.3 in early bovine embryos., [RefSeq, PubMed]; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IFS1;Q862G6;Q862V0;Q862W6", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000776 kinetochore;GO:0000781 chromosome, telomeric region;GO:0000786 nucleosome", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0030307 positive regulation of cell growth;GO:0006334 nucleosome assembly;GO:0007080 mitotic metaphase chromosome alignment;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5E9F8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66LN0-1", "uniprot_id": [ { "id": "PGES2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q66LN0", "type": "external" } ], "mass": 41738.0, "length": 372, "protein_name": "Prostaglandin E synthase 2", "gene_name": "PTGES2", "organism": "Bovine", "refseq_name": "prostaglandin E synthase 2", "refseq_ac": [ { "id": "NP_001160026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160026", "type": "external" } ], "gene_names_uniprotkb": "PTGES2; PGES2", "gene_names_refseq": "MPGES-2; PTGES2", "protein_names_uniprotkb": "Prostaglandin E synthase 2; 5.3.99.3; Membrane-associated prostaglandin E synthase-2; Microsomal prostaglandin E synthase 2; mPGE synthase-2; mPGES-2", "protein_names_refseq": "mPGE synthase-2; membrane-associated prostaglandin E synthase-2; microsomal prostaglandin E synthase-2; prostaglandin E synthase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:493639); (R-BTA-2162123); (R-BTA-6798695)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10446427;11866447;15744024;19393038", "class_list": "", "function": "Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:10446427, PubMed:11866447). The biological function and the GSH-dependent property of PTGES2 is still under debate (By similarity). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1N1J6", "ec_number_list": [ { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" } ], "go_molecular_function": "GO:0043295 glutathione binding;GO:0020037 heme binding;GO:0016829 lyase activity;GO:0050220 prostaglandin-E synthase activity;GO:0036134 12-hydroxyheptadecatrienoic acid synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005737 cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q66LN0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q865S1-1", "uniprot_id": [ { "id": "AP3D1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q865S1", "type": "external" } ], "mass": 136390.0, "length": 1207, "protein_name": "AP-3 complex subunit delta-1", "gene_name": "AP3D1", "organism": "Bovine", "refseq_name": "AP-3 complex subunit delta-1", "refseq_ac": [ { "id": "NP_776423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776423", "type": "external" } ], "gene_names_uniprotkb": "AP3D1; BLVR", "gene_names_refseq": "AP3D1; BLVR", "protein_names_uniprotkb": "AP-3 complex subunit delta-1; AP-3 complex subunit delta; Adaptor-related protein complex 3 subunit delta-1; BLV-R; BLVPCP1; Bovine leukemia virus cell receptor; Delta-adaptin", "protein_names_refseq": "AP-3 complex subunit delta-1; AP-3 complex subunit delta; BLV-R; BLVPCP1; adapter-related protein complex 3 subunit delta-1; adaptor related protein complex 3 delta 1 subunit; bovine leukemia virus, cell receptor; delta-adaptin", "tax_id": 9913, "disease": "", "pathway": " (bta:281023)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12692298;29928016;7998843;8063760;8380453", "class_list": "", "function": "A functional annotation of boAP3D1 cellular adaptor protein and BLV gp51, is reported. Publication Status: Online-Only, [RefSeq, PubMed]; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q03368;Q28876", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0043195 terminal bouton;GO:0010008 endosome membrane;GO:0030123 AP-3 adaptor complex;GO:0098830 presynaptic endosome", "go_biological_process": "GO:0008089 anterograde axonal transport;GO:0016182 synaptic vesicle budding from endosome;GO:0048490 anterograde synaptic vesicle transport;GO:0048499 synaptic vesicle membrane organization;GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q865S1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SPP7-1", "uniprot_id": [ { "id": "PGRP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8SPP7", "type": "external" } ], "mass": 21063.0, "length": 190, "protein_name": "Peptidoglycan recognition protein 1", "gene_name": "PGLYRP1", "organism": "Bovine", "refseq_name": "peptidoglycan recognition protein 1 precursor", "refseq_ac": [ { "id": "NP_776998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776998", "type": "external" } ], "gene_names_uniprotkb": "PGLYRP1; PGLYRP; PGRP", "gene_names_refseq": "PGLYRP1; PGLYRP", "protein_names_uniprotkb": "Peptidoglycan recognition protein 1; OBP; Oligosaccharide-binding protein; PGRP-S; Peptidoglycan recognition protein short", "protein_names_refseq": "OBP; PGRP-S; oligosaccharide-binding protein; peptidoglycal recognition protein 1; peptidoglycan recognition protein 1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:282305); (R-BTA-6798695); (R-BTA-6803157)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11880375;16394004;18639626;21749417;23820447", "class_list": "", "function": "Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6., [RefSeq, PubMed]; Bovine PGLYRP1 polymorphisms associates with resistance to Mycobacterium avium ssp. paratuberculosis., [RefSeq, PubMed]; Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity (PubMed:11880375, PubMed:16394004). Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Also promotes the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Polymorphisms in PGLYRP-1 gene were associated with mastitis resistance and 305-day milk yield, and the H3H3 haplotype would provide a useful genetic marker of combined haplotypes for mastitis resistance selection and breeding in Chinese Holstein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJC0;B5T256;B5T261", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042834 peptidoglycan binding;GO:0008745 N-acetylmuramoyl-L-alanine amidase activity;GO:0008270 zinc ion binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0016045 detection of bacterium", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8SPP7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95KV1-1", "uniprot_id": [ { "id": "IKKA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q95KV1", "type": "external" } ], "mass": 84344.0, "length": 740, "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "organism": "Bovine", "refseq_name": "inhibitor of nuclear factor kappa-B kinase subunit alpha", "refseq_ac": [ { "id": "NP_776446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776446", "type": "external" } ], "gene_names_uniprotkb": "CHUK; IKKA", "gene_names_refseq": "CHUK", "protein_names_uniprotkb": "Inhibitor of nuclear factor kappa-B kinase subunit alpha; 2.7.11.10; I-kappa-B kinase 1; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IKK1; IkBKA; NFKBIKA; Nuclear factor NF-kappa-B inhibitor kinase alpha", "protein_names_refseq": "I-kappa-B kinase 1; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IKK1; NFKBIKA; conserved helix-loop-helix ubiquitous kinase; i kappa-B kinase alpha; ikBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha; nuclear factor NF-kappa-B inhibitor kinase alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:281073); (R-BTA-1169091); (R-BTA-1810476); (R-BTA-202424); (R-BTA-2871837); (R-BTA-445989); (R-BTA-5357905); (R-BTA-5357956); (R-BTA-5607761); (R-BTA-5607764); (R-BTA-5676590); (R-BTA-5684264); (R-BTA-9020702); (R-BTA-933542); (R-BTA-937039); (R-BTA-937041); (R-BTA-975144); (R-BTA-9758274); (R-BTA-9833482); (R-BTA-9860276); (R-BTA-9860927); (R-BTA-9909505)", "pathway_count": 22, "publication_count": 1, "publication_id_list": "12459277", "class_list": "", "function": "Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor. Interacts with SASH1 (By similarity). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7YWD1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0008384 IkappaB kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0008385 IkappaB kinase complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0033209 tumor necrosis factor-mediated signaling pathway;GO:0071356 cellular response to tumor necrosis factor", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q95KV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95KV7-1", "uniprot_id": [ { "id": "NDUAD_BOVIN", "url": "https://www.uniprot.org/uniprot/Q95KV7", "type": "external" } ], "mass": 16673.0, "length": 144, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "gene_name": "NDUFA13", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "refseq_ac": [ { "id": "NP_788845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788845", "type": "external" } ], "gene_names_uniprotkb": "NDUFA13; GRIM19", "gene_names_refseq": "GRIM19; NDUFA13", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; CI-B16.6; Cell death regulatory protein GRIM-19; Complex I-B16.6; GRIM-19; Gene associated with retinoic-interferon-induced mortality 19 protein; NADH-ubiquinone oxidoreductase B16.6 subunit", "protein_names_refseq": "CI-B16.6; GRIM-19; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; NADH-ubiquinone oxidoreductase B16.6 subunit; cell death regulatory protein GRIM-19; cell death-regulatory protein GRIM19; complex I-B16.6; gene associated with retinoic-interferon-induced mortality 19 protein", "tax_id": 9913, "disease": "", "pathway": " (bta:338084); (R-BTA-611105); (R-BTA-6799198); (R-BTA-9837999)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11522775;18721790;28100784", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0G4", "ec_number_list": [], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006915 apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q95KV7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9BEA2-1", "uniprot_id": [ { "id": "ACSM1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9BEA2", "type": "external" } ], "mass": 64923.0, "length": 577, "protein_name": "Acyl-coenzyme A synthetase ACSM1, mitochondrial", "gene_name": "ACSM1", "organism": "Bovine", "refseq_name": "acyl-coenzyme A synthetase ACSM1, mitochondrial", "refseq_ac": [ { "id": "NP_777107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777107", "type": "external" } ], "gene_names_uniprotkb": "ACSM1; BUCS1; LAE; MACS1", "gene_names_refseq": "ACSM1; BUCS1", "protein_names_uniprotkb": "Acyl-coenzyme A synthetase ACSM1, mitochondrial; 6.2.1.25; 6.2.1.2; Acyl-CoA synthetase medium-chain family member 1; Benzoate--CoA ligase; Butyrate--CoA ligase 1; Butyryl-coenzyme A synthetase 1; Lipoate-activating enzyme; Middle-chain acyl-CoA synthetase 1; XL-III; XM-ligase 3; Xenobiotic/medium-chain fatty acid:CoA ligase XL-3", "protein_names_refseq": "XL-III; XM-ligase 3; acyl-coenzyme A synthetase ACSM1, mitochondrial; benzoate--CoA ligase; butyrate--CoA ligase 1; butyryl Coenzyme A synthetase 1; butyryl-coenzyme A synthetase 1; lipoate-activating enzyme; middle-chain acyl-CoA synthetase 1; xenobiotic/medium-chain fatty acid:CoA ligase XL-3", "tax_id": 9913, "disease": "", "pathway": " (bta:282576)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10561077;11382754;16378734", "class_list": "", "function": "Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10561077, PubMed:11382754). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10561077, PubMed:11382754). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (PubMed:11382754). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (PubMed:11382754)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32LF8;Q9TVB5;Q9XT43", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0102391 decanoate-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9BEA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9N0F3-1", "uniprot_id": [ { "id": "SYSM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9N0F3", "type": "external" } ], "mass": 58296.0, "length": 518, "protein_name": "Serine--tRNA ligase, mitochondrial", "gene_name": "SARS2", "organism": "Bovine", "refseq_name": "serine--tRNA ligase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776882", "type": "external" } ], "gene_names_uniprotkb": "SARS2; SARSM", "gene_names_refseq": "SARS2; SerRS", "protein_names_uniprotkb": "Serine--tRNA ligase, mitochondrial; 6.1.1.11; SerRSmt; SerRS; Seryl-tRNA synthetase; Seryl-tRNA(Ser/Sec) synthetase", "protein_names_refseq": "serRSmt; serine--tRNA ligase, mitochondrial precursor; serine--tRNA ligase, mitochondrial; seryl-tRNA synthetase, mitochondrial; seryl-tRNA(Ser/Sec) synthetase", "tax_id": 9913, "disease": "", "pathway": " (bta:282060)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10764807;16163389;16305752", "class_list": "", "function": "Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D7G7;Q58CP7;Q58DN2", "ec_number_list": [ { "id": "6.1.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.11", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004828 serine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006434 seryl-tRNA aminoacylation;GO:0070158 mitochondrial seryl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9N0F3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9N1F0-1", "uniprot_id": [ { "id": "IRAG1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9N1F0", "type": "external" } ], "mass": 98375.0, "length": 911, "protein_name": "Inositol 1,4,5-triphosphate receptor associated 1", "gene_name": "IRAG1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IRAG1; IRAG; MRVI1", "gene_names_refseq": "", "protein_names_uniprotkb": "Inositol 1,4,5-triphosphate receptor associated 1; Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate; JAW1-related protein MRVI1; Protein MRVI1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "10724174;11309393;12480535;16166082", "class_list": "", "function": "Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Also mediates NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9N1E9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9N1F0-1", "record_type": "protein", "filter_code": "0000000.0100100.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9TU23-1", "uniprot_id": [ { "id": "CE290_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9TU23", "type": "external" } ], "mass": 171787.0, "length": 1468, "protein_name": "Centrosomal protein of 290 kDa", "gene_name": "CEP290", "organism": "Bovine", "refseq_name": "centrosomal protein of 290 kDa", "refseq_ac": [ { "id": "NP_777147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777147", "type": "external" } ], "gene_names_uniprotkb": "CEP290; NPHP6", "gene_names_refseq": "CEP290", "protein_names_uniprotkb": "Centrosomal protein of 290 kDa; Cep290; Nephrocystin-6", "protein_names_refseq": "centrosomal protein of 290 kDa; nephrocystin-6", "tax_id": 9913, "disease": "", "pathway": " (bta:282707)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22940612;41018975", "class_list": "", "function": "Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. Required for efficient recruitment of RAB8A to primary cilium. In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5. Activates ATF4-mediated transcription., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P567", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005814 centriole", "go_biological_process": "GO:0015031 protein transport;GO:0090316 positive regulation of intracellular protein transport;GO:0045893 positive regulation of DNA-templated transcription;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9TU23-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9TU34-1", "uniprot_id": [ { "id": "ITPR1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9TU34", "type": "external" } ], "mass": 308318.0, "length": 2709, "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1", "gene_name": "ITPR1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ITPR1", "gene_names_refseq": "", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; IP3 receptor isoform 1; IP3R 1; Inositol 1,4,5-trisphosphate receptor type 1; InsP3R1; Type 1 InsP3 receptor; Type 1 inositol 1,4,5-trisphosphate receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:317697)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10724174;11309393;11584008;12480535;2174422", "class_list": "", "function": "Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (By similarity). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity). Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7M2U0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity;GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0007338 single fertilization;GO:0051209 release of sequestered calcium ion into cytosol;GO:0036444 calcium import into the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9TU34-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9XSK0-1", "uniprot_id": [ { "id": "CRX_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9XSK0", "type": "external" } ], "mass": 32253.0, "length": 299, "protein_name": "Cone-rod homeobox protein", "gene_name": "CRX", "organism": "Bovine", "refseq_name": "cone-rod homeobox protein", "refseq_ac": [ { "id": "NP_776329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776329", "type": "external" } ], "gene_names_uniprotkb": "CRX", "gene_names_refseq": "CRX", "protein_names_uniprotkb": "Cone-rod homeobox protein", "protein_names_refseq": "cone-rod homeobox protein; retina and pineal-specific transcription factor", "tax_id": 9913, "disease": "", "pathway": " (bta:280756)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18849347", "class_list": "", "function": "OTR1, OTX2 and CRX act as positive modulators of the BEST1 promoter in the retinal pigment epithelium., [RefSeq, PubMed]; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9XSK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07224-1", "uniprot_id": [ { "id": "PROS_BOVIN", "url": "https://www.uniprot.org/uniprot/P07224", "type": "external" } ], "mass": 75133.0, "length": 675, "protein_name": "Vitamin K-dependent protein S", "gene_name": "PROS1", "organism": "Bovine", "refseq_name": "vitamin K-dependent protein S precursor", "refseq_ac": [ { "id": "NP_776863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776863", "type": "external" } ], "gene_names_uniprotkb": "PROS1; PROS", "gene_names_refseq": "PROS1", "protein_names_uniprotkb": "Vitamin K-dependent protein S", "protein_names_refseq": "protein S (alpha); vitamin K-dependent protein S precursor; vitamin K-dependent protein S", "tax_id": 9913, "disease": "", "pathway": " (bta:282006); (R-BTA-114608); (R-BTA-159740); (R-BTA-159763); (R-BTA-159782); (R-BTA-202733); (R-BTA-9769735); (R-BTA-9769739); (R-BTA-9769743)", "pathway_count": 9, "publication_count": 4, "publication_id_list": "12888869;26495903;2937785;2940598", "class_list": "", "function": "Activated protein C(APC) combined with protein S(PS) had significant antithrombotic effect. APC combined with PS prolonged clotting time. Dependence on APC-cofactor activity of PS for expression of anticoagulant activity by APC., [RefSeq, PubMed]; Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007596 blood coagulation;GO:0042730 fibrinolysis;GO:0050819 negative regulation of coagulation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07224-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28055-1", "uniprot_id": [ { "id": "ARP19_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28055", "type": "external" } ], "mass": 12353.0, "length": 112, "protein_name": "cAMP-regulated phosphoprotein 19", "gene_name": "ARPP19", "organism": "Bovine", "refseq_name": "cAMP-regulated phosphoprotein 19 isoform 1", "refseq_ac": [ { "id": "NP_001106726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106726", "type": "external" } ], "gene_names_uniprotkb": "ARPP19", "gene_names_refseq": "ARPP-16; ARPP-19; ARPP19", "protein_names_uniprotkb": "cAMP-regulated phosphoprotein 19; ARPP-19", "protein_names_refseq": "cAMP-regulated phosphoprotein 19 isoform 1; cAMP-regulated phosphoprotein, 19kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:282658); (R-BTA-2465910)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "2160982", "class_list": "", "function": "Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q28054", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0051721 protein phosphatase 2A binding;GO:0019212 phosphatase inhibitor activity;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28055-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02510-1", "uniprot_id": [ { "id": "CRYAB_BOVIN", "url": "https://www.uniprot.org/uniprot/P02510", "type": "external" } ], "mass": 20037.0, "length": 175, "protein_name": "Alpha-crystallin B chain", "gene_name": "CRYAB", "organism": "Bovine", "refseq_name": "alpha-crystallin B chain", "refseq_ac": [ { "id": "NP_776715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776715", "type": "external" } ], "gene_names_uniprotkb": "CRYAB; CRYA2", "gene_names_refseq": "CRYAB", "protein_names_uniprotkb": "Alpha-crystallin B chain; Alpha(B)-crystallin", "protein_names_refseq": "alpha crystallin B; alpha(B)-crystallin; alpha-crystallin B chain; crystallin, alpha polypeptide 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281719); (R-BTA-3371571)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "1304359;1687959;1730617;19245863;19284785;19936900;21158410;21314599;21445944;21975426;24131013;2599111;26215735;26644245;30657688;3579961;38665916;4477528;7912928;8114688", "class_list": "", "function": "Alpha-crystallin is characterized by homogeneous distribution of scattering density in the domains inaccessible for water penetration, [RefSeq, PubMed]; Analysis of the structural, molecular and spectroscopic changes in alpha-crystallin protein as it slowly denatures due to aggregation induced by non-enzymatic glycation, [RefSeq, PubMed]; In the presence of alpha-crystallin or GroEL the kinetic of GAPDH aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation., [RefSeq, PubMed]; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The alphaB-crystallin content of bovine type I muscle fibers is quantitatively similar to that in the predominantly type I fibers of rat soleus muscle., [RefSeq, PubMed]; These results show that between pH 7 and 10 the protein undergoes a reversible thermal transition., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 2, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O46508;Q3SZQ9", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0032387 negative regulation of intracellular transport;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0009408 response to heat;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P02510-1", "record_type": "protein", "filter_code": "0000000.0010101.100000.010000000000000000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43249-1", "uniprot_id": [ { "id": "GRK5_BOVIN", "url": "https://www.uniprot.org/uniprot/P43249", "type": "external" } ], "mass": 67889.0, "length": 590, "protein_name": "G protein-coupled receptor kinase 5", "gene_name": "GRK5", "organism": "Bovine", "refseq_name": "G protein-coupled receptor kinase 5", "refseq_ac": [ { "id": "NP_776756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776756", "type": "external" } ], "gene_names_uniprotkb": "GRK5; GPRK5", "gene_names_refseq": "GPRK5; GRK5", "protein_names_uniprotkb": "G protein-coupled receptor kinase 5; 2.7.11.16; G protein-coupled receptor kinase GRK5", "protein_names_refseq": "G protein-coupled receptor kinase 5; g protein-coupled receptor kinase GRK5", "tax_id": 9913, "disease": "", "pathway": " (bta:281801); (R-BTA-418555)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "19008357;22952844;25332207;8120045", "class_list": "", "function": "GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity., [RefSeq, PubMed]; GRK5, acting in a kinase independent manner, is a facilitator of NFAT activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription., [RefSeq, PubMed]; Potential GRK5 interacting proteins and the association of GRK5 with DDB1 in cell and the regulation of GRK5 level by DDB1-CUL4 ubiquitin ligase complex-dependent proteolysis pathway, [RefSeq, PubMed]; Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors (Beta-2 adrenergic receptor), muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor, LRP6 during Wnt signaling (in vitro) (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008289 lipid binding;GO:0004703 G protein-coupled receptor kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0031965 nuclear membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0016055 Wnt signaling pathway;GO:0009966 regulation of signal transduction;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P43249-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42028-1", "uniprot_id": [ { "id": "NDUS8_BOVIN", "url": "https://www.uniprot.org/uniprot/P42028", "type": "external" } ], "mass": 23896.0, "length": 212, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial", "gene_name": "NDUFS8", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial", "refseq_ac": [ { "id": "NP_001289598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289598", "type": "external" } ], "gene_names_uniprotkb": "NDUFS8", "gene_names_refseq": "NDUFS8", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; 7.1.1.2; CI-23kD; Complex I-23kD; NADH-ubiquinone oxidoreductase 23 kDa subunit; TYKY subunit", "protein_names_refseq": "CI-23kD; NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; NADH dehydrogenase ubiquinone Fe-S 8; NADH-ubiquinone oxidoreductase 23 kDa subunit; TYKY subunit; complex I-23kD", "tax_id": 9913, "disease": "", "pathway": " (bta:287027); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10852722;18721790;1901022;25209663", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790). Essential for the catalytic activity and assembly of complex I (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32KV7", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I;GO:0016020 membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P42028-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07470-1", "uniprot_id": [ { "id": "CX7A1_BOVIN", "url": "https://www.uniprot.org/uniprot/P07470", "type": "external" } ], "mass": 9063.0, "length": 80, "protein_name": "Cytochrome c oxidase subunit 7A1, mitochondrial", "gene_name": "COX7A1", "organism": "Bovine", "refseq_name": "cytochrome c oxidase subunit 7A1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_788847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788847", "type": "external" } ], "gene_names_uniprotkb": "COX7A1; COX7AH; COX7A", "gene_names_refseq": "COX7A1; COX; VIIIC; VIIa-M", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7A1, mitochondrial; Cytochrome c oxidase subunit VIIIc; Cytochrome c oxidase subunit VIIa-H; Cytochrome c oxidase subunit VIIa-M; Cytochrome c oxidase subunit VIIa-heart; Cytochrome c oxidase subunit VIIa-muscle; VIIIC", "protein_names_refseq": "cytochrome c oxidase polypeptide VIIa-heart; cytochrome c oxidase subunit 7A1, mitochondrial precursor; cytochrome c oxidase subunit 7A1, mitochondrial; cytochrome c oxidase subunit VIIIc; cytochrome c oxidase subunit VIIa polypeptide 1 (muscle); cytochrome c oxidase subunit VIIa-H; cytochrome c oxidase subunit VIIa-M; cytochrome c oxidase subunit VIIa-heart; cytochrome c oxidase subunit VIIa-muscle", "tax_id": 9913, "disease": "", "pathway": " (bta:338086); (R-BTA-5628897); (R-BTA-611105); (R-BTA-9707564); (R-BTA-9864848)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10089392;10771420;1316159;1717471;20385840;26698328;27605664;27830641;3006725;31533957;8638158", "class_list": "", "function": "Component of the mitochondrial respiratory complex IV (CIV, also named cytochrome c oxidase complex), the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:10089392, PubMed:10771420, PubMed:20385840, PubMed:27605664, PubMed:27830641, PubMed:31533957, PubMed:8638158). The CIV complex is the component of the respiratory chain that catalyzes the reduction of oxygen to water (By similarity). Acts as an assembly factor that specifically drives the homodimerization of CIV complexes, mediating the formation of mitochondrial respiratory supercomplexes (respirasomes) containing two CIV: supercomplxes with two molecules of CIV show improved activity (By similarity). Despite being highly expressed in brown adipose tissue, not required for thermogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FUH9", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0016491 oxidoreductase activity;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV;GO:0098803 respiratory chain complex", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0006119 oxidative phosphorylation;GO:0097250 mitochondrial respirasome assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P07470-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00586-1", "uniprot_id": [ { "id": "THTR_BOVIN", "url": "https://www.uniprot.org/uniprot/P00586", "type": "external" } ], "mass": 33296.0, "length": 297, "protein_name": "Thiosulfate sulfurtransferase", "gene_name": "TST", "organism": "Bovine", "refseq_name": "thiosulfate sulfurtransferase", "refseq_ac": [ { "id": "NP_803455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803455", "type": "external" } ], "gene_names_uniprotkb": "TST", "gene_names_refseq": "TST", "protein_names_uniprotkb": "Thiosulfate sulfurtransferase; 2.8.1.1; Rhodanese", "protein_names_refseq": "rhodanese; thiosulfate sulfurtransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:280946); (R-BTA-1614558)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12433928;12962704;16305752;2002017;22076378;28100784;6575830;691057;711737;711738;8132546;8702871;9761843", "class_list": "", "function": "Active rhodanese lacking nonessential sulfhydryl groups contains an unstable C-terminal domain and can be bound, inactivated, and reactivated by GroEL, [RefSeq, PubMed]; Catalyzes the transfer of sulfur ion from thiosulfate to cyanide, although other thiol compounds, besides cyanide, can act as sulfur ion acceptors (PubMed:711738). It also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Has a pivotal role in cyanide detoxification (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Data suggest that inhibition of rhodanese activity is a result of the formation of stable S-nitrosorhodanese, and that low molecular weight nitric oxide donors are much more effective than such known inhibitors of this enzyme., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2KIM8;Q5E9C5", "ec_number_list": [ { "id": "2.8.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.1", "type": "external" } ], "go_molecular_function": "GO:0016783 sulfurtransferase activity;GO:0008097 5S rRNA binding;GO:0004792 thiosulfate-cyanide sulfurtransferase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0051029 rRNA transport;GO:0035928 rRNA import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P00586-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13271-1", "uniprot_id": [ { "id": "QCR8_BOVIN", "url": "https://www.uniprot.org/uniprot/P13271", "type": "external" } ], "mass": 9720.0, "length": 82, "protein_name": "Cytochrome b-c1 complex subunit 8", "gene_name": "UQCRQ", "organism": "Bovine", "refseq_name": "cytochrome b-c1 complex subunit 8", "refseq_ac": [ { "id": "NP_777230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777230", "type": "external" } ], "gene_names_uniprotkb": "UQCRQ", "gene_names_refseq": "QP-C; UQCRQ", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 8; Complex III subunit 8; Complex III subunit VIII; Ubiquinol-cytochrome c reductase complex 9.5 kDa protein; Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C", "protein_names_refseq": "complex III subunit 8; complex III subunit VIII; cytochrome b-c1 complex subunit 8; low molecular mass ubiquinone-binding protein (9.5kD); ubiquinol-cytochrome c reductase complex 9.5 kDa protein; ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C; ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:286885)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12269811;15312779;16024040;16924113;2164842;28100784;3009231;7592738;9204897;9651245", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBT9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0021766 hippocampus development;GO:0021680 cerebellar Purkinje cell layer development;GO:0021860 pyramidal neuron development;GO:0021854 hypothalamus development;GO:0021539 subthalamus development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P13271-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49951-1", "uniprot_id": [ { "id": "CLH1_BOVIN", "url": "https://www.uniprot.org/uniprot/P49951", "type": "external" } ], "mass": 191589.0, "length": 1675, "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "organism": "Bovine", "refseq_name": "clathrin heavy chain 1", "refseq_ac": [ { "id": "NP_776448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776448", "type": "external" } ], "gene_names_uniprotkb": "CLTC", "gene_names_refseq": "CLTC", "protein_names_uniprotkb": "Clathrin heavy chain 1", "protein_names_refseq": "clathrin heavy chain 1; clathrin, heavy chain (Hc); clathrin, heavy polypeptide (Hc)", "tax_id": 9913, "disease": "", "pathway": " (bta:281080); (R-BTA-177504); (R-BTA-190873); (R-BTA-196025); (R-BTA-2132295); (R-BTA-432720); (R-BTA-432722); (R-BTA-437239); (R-BTA-5099900); (R-BTA-5140745); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-8866427); (R-BTA-8964038); (R-BTA-9013420); (R-BTA-9013424)", "pathway_count": 16, "publication_count": 8, "publication_id_list": "11470803;15502813;20033059;20154091;25844500;34147763;7585943;8524399", "class_list": "", "function": "Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (PubMed:11470803, PubMed:15502813, PubMed:8524399)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Entry of bovine parainfluenza virus type 3 into MDBK cells occurs via clathrin-mediated endocytosis and macropinocytosis in a acid-dependent manner., [RefSeq, PubMed]; Structure of clathrin coat with bound Hsc70 and auxilin., [RefSeq, PubMed]; Three different clathrin-box motif peptides can each simultaneously bind not only to the previously characterized clathrin-box site but also to the W-box site and the beta-arrestin splice loop site on a single TD., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:1990763 arrestin family protein binding;GO:0097718 disordered domain specific binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005819 spindle;GO:0042470 melanosome;GO:0045334 clathrin-coated endocytic vesicle;GO:0030130 clathrin coat of trans-Golgi network vesicle", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006886 intracellular protein transport;GO:0051301 cell division;GO:0006914 autophagy;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P49951-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LG3-1", "uniprot_id": [ { "id": "MDHM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LG3", "type": "external" } ], "mass": 35668.0, "length": 338, "protein_name": "Malate dehydrogenase, mitochondrial", "gene_name": "MDH2", "organism": "Bovine", "refseq_name": "malate dehydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_001013605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013605", "type": "external" } ], "gene_names_uniprotkb": "MDH2", "gene_names_refseq": "MDH2", "protein_names_uniprotkb": "Malate dehydrogenase, mitochondrial; 1.1.1.37", "protein_names_refseq": "malate dehydrogenase 2, NAD (mitochondrial); malate dehydrogenase 2, mitochondrial; malate dehydrogenase, mitochondrial; mitochondrial malate dehydrogenase 2, NAD", "tax_id": 9913, "disease": "", "pathway": " (bta:281306); (R-BTA-71403); (R-BTA-9837999); (R-BTA-9856872)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "22076378;28100784", "class_list": "", "function": "Mitochondrial malate dehydrogenase that catalyzes the reversible conversion of malate to oxaloacetate using NAD(+) as a cofactor. Plays a central role in the tricarboxylic acid (TCA) cycle contributing to cellular respiration and energy production via the mitochondrial electron transport chain (By similarity). Also participates in the malate-aspartate NADH shuttle, facilitating transfer of reducing equivalents between cytosol and mitochondria to maintain redox balance (NAD(+)/NADH homeostasis) and support metabolic flux between compartments (By similarity). In addition to its metabolic role, binds to RNA in cells, associating with cytosolic RNAs including tRNAs and mRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "1.1.1.399", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.399", "type": "external" }, { "id": "1.1.1.95", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.95", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0030060 L-malate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0016020 membrane", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006094 gluconeogenesis;GO:0009060 aerobic respiration;GO:0006108 malate metabolic process;GO:0043490 malate-aspartate shuttle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q32LG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29626-1", "uniprot_id": [ { "id": "PTGIS_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29626", "type": "external" } ], "mass": 56629.0, "length": 500, "protein_name": "Prostacyclin synthase", "gene_name": "PTGIS", "organism": "Bovine", "refseq_name": "prostacyclin synthase", "refseq_ac": [ { "id": "NP_776869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776869", "type": "external" } ], "gene_names_uniprotkb": "PTGIS; CYP8", "gene_names_refseq": "PTGIS", "protein_names_uniprotkb": "Prostacyclin synthase; 4.2.1.152; 5.3.99.4; Hydroperoxy icosatetraenoate dehydratase; Prostaglandin I2 synthase", "protein_names_refseq": "hydroperoxy icosatetraenoate dehydratase; prostacyclin synthase; prostaglandin I2 (prostacyclin) synthase", "tax_id": 9913, "disease": "", "pathway": " (bta:282021); (R-BTA-211979); (R-BTA-2162123)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12562775;8051072;8074709;8280118", "class_list": "", "function": "Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2)., [UniProtKB, UniProtKB, UniProtKB]; Specific nitration at tyrosine 430 is revealed by high resolution mass spectrometry as basis for redox regulation of this enzyme., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5G0;Q28841", "ec_number_list": [ { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.1", "type": "external" }, { "id": "5.3.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.4", "type": "external" } ], "go_molecular_function": "GO:0008116 prostaglandin-I synthase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005901 caveola;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006690 icosanoid metabolic process;GO:0045766 positive regulation of angiogenesis;GO:0050728 negative regulation of inflammatory response;GO:0071456 cellular response to hypoxia;GO:0045019 negative regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q29626-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00130-1", "uniprot_id": [ { "id": "QCR9_BOVIN", "url": "https://www.uniprot.org/uniprot/P00130", "type": "external" } ], "mass": 7458.0, "length": 64, "protein_name": "Cytochrome b-c1 complex subunit 9", "gene_name": "UQCR10", "organism": "Bovine", "refseq_name": "cytochrome b-c1 complex subunit 9", "refseq_ac": [ { "id": "NP_001107195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107195", "type": "external" } ], "gene_names_uniprotkb": "UQCR10", "gene_names_refseq": "UCRC; UQCR10", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 9; Complex III subunit 9; Complex III subunit X; Cytochrome c1 non-heme 7 kDa protein; Ubiquinol-cytochrome c reductase complex 7.2 kDa protein", "protein_names_refseq": "complex III subunit 9; complex III subunit X; cytochrome b-c1 complex subunit 9; cytochrome c1 non-heme 7 kDa protein; ubiquinol-cytochrome c reductase complex 7.2 kDa protein", "tax_id": 9913, "disease": "", "pathway": " (bta:616109); (R-BTA-611105); (R-BTA-9865881)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12269811;15312779;16024040;16924113;6305819;9204897;9651245", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZT3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P00130-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02371-1", "uniprot_id": [ { "id": "NDUA3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02371", "type": "external" } ], "mass": 9349.0, "length": 84, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3", "gene_name": "NDUFA3", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3", "refseq_ac": [ { "id": "NP_788832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788832", "type": "external" } ], "gene_names_uniprotkb": "NDUFA3", "gene_names_refseq": "CI-B9; NDUFA3", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3; CI-B9; Complex I-B9; NADH-ubiquinone oxidoreductase B9 subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3; NADH-ubiquinone oxidoreductase B9 subunit; complex I-B9", "tax_id": 9913, "disease": "", "pathway": " (bta:338064); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1518044;18721790;7958365", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZS6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02371-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00743-1", "uniprot_id": [ { "id": "FA10_BOVIN", "url": "https://www.uniprot.org/uniprot/P00743", "type": "external" } ], "mass": 54510.0, "length": 492, "protein_name": "Coagulation factor X", "gene_name": "F10; F7", "organism": "Bovine", "refseq_name": "coagulation factor X precursor", "refseq_ac": [ { "id": "NP_001073682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073682", "type": "external" } ], "gene_names_uniprotkb": "F10; F7; F7", "gene_names_refseq": "F10", "protein_names_uniprotkb": "Coagulation factor X; 3.4.21.6; Stuart factor", "protein_names_refseq": "coagulation factor X precursor; stuart factor", "tax_id": 9913, "disease": "", "pathway": " (bta:280787); (R-BTA-159740); (R-BTA-159763); (R-BTA-159782); (R-BTA-9769735); (R-BTA-9769739); (R-BTA-9769743)", "pathway_count": 7, "publication_count": 20, "publication_id_list": "1059093;1059122;1527084;1627540;18296445;22383955;2261466;25572019;28782177;34831181;37469515;3949800;4264286;6330671;6546930;6688526;6766735;6767721;8243461;8794734", "class_list": "", "function": "Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest factor Xa (FXa) and factor Va (FVa) compete to bind FXa on both PS model membranes and microparticles from activated platelets; this competition between dimerization/prothrombinase complex formation appears to regulate blood coagulation., [RefSeq, PubMed]; Factor Xa (fXa), a key serine protease of the coagulation system, was used as a model enzyme to test the canonical conformation hypothesis., [RefSeq, PubMed]; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (By similarity). Factor Xa activates pro-inflammatory and pro-fibrotic signaling pathways in a protease-activated receptor (PAR)-dependent manner (By similarity)., [UniProtKB, UniProtKB]; Identify potential phosphatidylserine-specific binding sites in the membrane binding domain of coagulation factor X., [RefSeq, PubMed]; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 11, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 18, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "3.4.21.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.22", "type": "external" }, { "id": "3.4.21.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6", "type": "external" }, { "id": "3.4.21.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.21", "type": "external" }, { "id": "4.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P00743-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00126-1", "uniprot_id": [ { "id": "QCR6_BOVIN", "url": "https://www.uniprot.org/uniprot/P00126", "type": "external" } ], "mass": 10624.0, "length": 91, "protein_name": "Cytochrome b-c1 complex subunit 6, mitochondrial", "gene_name": "UQCRH", "organism": "Bovine", "refseq_name": "cytochrome b-c1 complex subunit 6, mitochondrial", "refseq_ac": [ { "id": "NP_001029917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029917", "type": "external" } ], "gene_names_uniprotkb": "UQCRH", "gene_names_refseq": "UQCRH", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 6, mitochondrial; Complex III subunit 6; Complex III subunit VIII; Cytochrome c1 non-heme 11 kDa protein; Mitochondrial hinge protein; Ubiquinol-cytochrome c reductase complex 11 kDa protein", "protein_names_refseq": "complex III subunit 6; complex III subunit VIII; cytochrome b-c1 complex subunit 6, mitochondrial; cytochrome c1 non-heme 11 kDa protein; mitochondrial hinge protein; ubiquinol-cytochrome c reductase complex 11 kDa protein", "tax_id": 9913, "disease": "", "pathway": " (bta:613899); (R-BTA-611105); (R-BTA-9865881)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12269811;15312779;16024040;16924113;3003044;6126477;9204897;9651245", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZS4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III;GO:0098803 respiratory chain complex", "go_biological_process": "GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P00126-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61085-1", "uniprot_id": [ { "id": "UBE2K_BOVIN", "url": "https://www.uniprot.org/uniprot/P61085", "type": "external" } ], "mass": 22407.0, "length": 200, "protein_name": "Ubiquitin-conjugating enzyme E2 K", "gene_name": "UBE2K", "organism": "Bovine", "refseq_name": "ubiquitin-conjugating enzyme E2 K", "refseq_ac": [ { "id": "NP_776505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776505", "type": "external" } ], "gene_names_uniprotkb": "UBE2K; HIP2", "gene_names_refseq": "E2-25K; HIP2; HYPG; LIG; UBE2K", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 K; 2.3.2.23; E2 ubiquitin-conjugating enzyme K; HIP-2; Huntingtin-interacting protein 2; Ubiquitin carrier protein; Ubiquitin-conjugating enzyme E2(25K); Ubiquitin-conjugating enzyme E2-25 kDa; Ubiquitin-conjugating enzyme E2-25K; Ubiquitin-protein ligase", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme K; E2(25K); HIP-2; huntingtin interacting protein 2; ubiquitin carrier protein; ubiquitin-conjugating enzyme E2 K; ubiquitin-conjugating enzyme E2-25 kDa; ubiquitin-conjugating enzyme E2-25K; ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); ubiquitin-protein ligase", "tax_id": 9913, "disease": "", "pathway": " (bta:281225); (R-BTA-8866652); (R-BTA-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1322903;15723079;1714895;9535861;9657692", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53 (By similarity). Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PK22;O54806;P27924;Q16721;Q9CVV9", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P61085-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EA71-1", "uniprot_id": [ { "id": "RM49_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5EA71", "type": "external" } ], "mass": 19268.0, "length": 166, "protein_name": "Large ribosomal subunit protein mL49", "gene_name": "MRPL49", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein mL49", "refseq_ac": [ { "id": "NP_001014871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014871", "type": "external" } ], "gene_names_uniprotkb": "MRPL49", "gene_names_refseq": "MRPL49", "protein_names_uniprotkb": "Large ribosomal subunit protein mL49; 39S ribosomal protein L49, mitochondrial; L49mt; MRP-L49", "protein_names_refseq": "39S ribosomal protein L49, mitochondrial; L49mt; MRP-L49; large ribosomal subunit protein mL49", "tax_id": 9913, "disease": "", "pathway": " (bta:508359)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16305752;20601428", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5C6", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5EA71-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9N1Q8-1", "uniprot_id": [ { "id": "CABP5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9N1Q8", "type": "external" } ], "mass": 19628.0, "length": 173, "protein_name": "Calcium-binding protein 5", "gene_name": "CABP5", "organism": "Bovine", "refseq_name": "calcium-binding protein 5", "refseq_ac": [ { "id": "NP_777153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777153", "type": "external" } ], "gene_names_uniprotkb": "CABP5", "gene_names_refseq": "CABP3; CABP5", "protein_names_uniprotkb": "Calcium-binding protein 5; CaBP5", "protein_names_refseq": "calcium binding protein 3; calcium-binding protein 5", "tax_id": 9913, "disease": "", "pathway": " (bta:282715)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10625670;22039235", "class_list": "", "function": "Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials (By similarity). Involved in the transmission of light signals (By similarity). May positively regulate neurotransmitter vesicle endocytosis and exocytosis in a salt-dependent manner (By similarity). May play a role in the extension and network organization of neurites (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This study shows that CaBP5 interacts with Munc18-1 and myosin VI, two proteins involved in the synaptic vesicle cycle stimulating neurite outgrowth and vesicle exocytosis Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0007601 visual perception;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9N1Q8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M2N1-1", "uniprot_id": [ { "id": "ARP21_BOVIN", "url": "https://www.uniprot.org/uniprot/Q7M2N1", "type": "external" } ], "mass": 9641.0, "length": 89, "protein_name": "cAMP-regulated phosphoprotein 21", "gene_name": "ARPP21", "organism": "Bovine", "refseq_name": "cAMP-regulated phosphoprotein 21", "refseq_ac": [ { "id": "NP_001070418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070418", "type": "external" } ], "gene_names_uniprotkb": "ARPP21; RCS", "gene_names_refseq": "ARPP-21; ARPP21", "protein_names_uniprotkb": "cAMP-regulated phosphoprotein 21; ARPP-21; Regulator of calmodulin signaling", "protein_names_refseq": "cAMP-regulated phosphoprotein 21; cAMP-regulated phosphoprotein, 21kDa; cyclic AMP-regulated phosphoprotein, 21 kDa; regulator of calmodulin signaling", "tax_id": 9913, "disease": "", "pathway": " (bta:618648)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15499021;2552036;2552037", "class_list": "", "function": "May act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0003730 mRNA 3'-UTR binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7M2N1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17694-1", "uniprot_id": [ { "id": "NDUS2_BOVIN", "url": "https://www.uniprot.org/uniprot/P17694", "type": "external" } ], "mass": 52556.0, "length": 463, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "gene_name": "NDUFS2", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001068605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068605", "type": "external" } ], "gene_names_uniprotkb": "NDUFS2", "gene_names_refseq": "NDUFS2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; 7.1.1.2; CI-49kD; Complex I-49kD; NADH-ubiquinone oxidoreductase 49 kDa subunit", "protein_names_refseq": "CI-49kD; NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH-ubiquinone oxidoreductase 49 kDa subunit; complex I-49kD", "tax_id": 9913, "disease": "", "pathway": " (bta:327697); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10852722;18721790;23836892;2498081;25209663;25419630", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790). Essential for the catalytic activity and assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (By similarity). Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Data suggest that the active site domain of NDUFS2 (a 49 kDa subunit of mitochondrial complex I) in bovine heart mitochondria exhibits more than one access path by which ligands/chemicals can reach reactive residues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5K5", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051287 NAD binding;GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0048038 quinone binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042063 gliogenesis;GO:0022008 neurogenesis;GO:0061351 neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P17694-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02376-1", "uniprot_id": [ { "id": "NDUC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02376", "type": "external" } ], "mass": 8784.0, "length": 76, "protein_name": "NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial", "gene_name": "NDUFC1", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776989", "type": "external" } ], "gene_names_uniprotkb": "NDUFC1", "gene_names_refseq": "CI-KFYI; NDUFC1", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial; CI-KFYI; Complex I-KFYI; NADH-ubiquinone oxidoreductase KFYI subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1 (6kD, KFYI); NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial; NADH-ubiquinone oxidoreductase KFYI subunit; complex I-KFYI", "tax_id": 9913, "disease": "", "pathway": " (bta:282289); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10852722;1518044;18721790", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0H7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02376-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22027-1", "uniprot_id": [ { "id": "ATP5S_BOVIN", "url": "https://www.uniprot.org/uniprot/P22027", "type": "external" } ], "mass": 23293.0, "length": 200, "protein_name": "ATP synthase subunit s, mitochondrial", "gene_name": "DMAC2L", "organism": "Bovine", "refseq_name": "ATP synthase subunit s, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001007813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007813", "type": "external" } ], "gene_names_uniprotkb": "DMAC2L; ATP5S; ATPW", "gene_names_refseq": "ATP5S; DMAC2L; FB", "protein_names_uniprotkb": "ATP synthase subunit s, mitochondrial; ATP synthase-coupling factor B; Distal membrane arm assembly complex 2-like protein; FB; Mitochondrial ATP synthase regulatory component factor B", "protein_names_refseq": "ATP synthase subunit s, mitochondrial precursor; ATP synthase subunit s, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B); ATP synthase, H+ transporting, mitochondrial Fo complex subunit s; ATP synthase-coupling factor B; distal membrane arm assembly complex 2 like; distal membrane arm assembly complex 2-like protein; factor B; mitochondrial ATP synthase regulatory component factor B", "tax_id": 9913, "disease": "", "pathway": " (bta:493709); (R-BTA-163210); (R-BTA-8949613)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12361715;16579955;18319055;18768789;2148527", "class_list": "", "function": "Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Report the cocrystal structures of Coupling factor B (FB) bound with phenylarsine oxide and Cd(2+), two known inhibitors of the FB coupling activity, [RefSeq, PubMed]; The N-terminal domain and in particular the proximal N-terminal amino acids of bovine factor B are important for its coupling activity and protein-protein interactions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32L55;Q5S3X8", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0006754 ATP biosynthetic process;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P22027-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46470-1", "uniprot_id": [ { "id": "RGS7_BOVIN", "url": "https://www.uniprot.org/uniprot/O46470", "type": "external" } ], "mass": 54685.0, "length": 469, "protein_name": "Regulator of G protein signaling 7", "gene_name": "RGS7", "organism": "Bovine", "refseq_name": "regulator of G-protein signaling 7", "refseq_ac": [ { "id": "NP_776594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776594", "type": "external" } ], "gene_names_uniprotkb": "RGS7", "gene_names_refseq": "RGS7", "protein_names_uniprotkb": "Regulator of G protein signaling 7; RGS7", "protein_names_refseq": "regulator of G-protein signaling 7; regulator of G-protein signalling 7", "tax_id": 9913, "disease": "", "pathway": " (bta:281452); (R-BTA-418594); (R-BTA-6814122)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11032900;9459445;9731233", "class_list": "", "function": "GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis (By similarity). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2HJA0", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O46470-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06836-1", "uniprot_id": [ { "id": "NEUM_BOVIN", "url": "https://www.uniprot.org/uniprot/P06836", "type": "external" } ], "mass": 25066.0, "length": 242, "protein_name": "Neuromodulin", "gene_name": "GAP43", "organism": "Bovine", "refseq_name": "neuromodulin", "refseq_ac": [ { "id": "NP_976234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976234", "type": "external" } ], "gene_names_uniprotkb": "GAP43", "gene_names_refseq": "GAP43", "protein_names_uniprotkb": "Neuromodulin; Axonal membrane protein GAP-43; Calmodulin-binding protein P-57; Growth-associated protein 43", "protein_names_refseq": "axonal membrane protein GAP-43; calmodulin-binding protein P-57; neuromodulin", "tax_id": 9913, "disease": "", "pathway": " (bta:281777); (R-BTA-373760)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1824693;1828073;19146979;20109554;2140056;2962637;8399217;8454596", "class_list": "", "function": "Both the synthetic N-terminal peptide GAP-43(1-40) and the brain-derived fragment GAP-43-3 preserved the ability to oligomerize under the action of acidic phospholipids and SDS., [RefSeq, PubMed]; These results indicated the interaction of GAP-43 and Galpha(o) could accelerate conversion of depalmitoylated Galpha(o) but not palmitoylated Galpha(o) from oligomers to monomers, so as to increase the GTPgammaS binding activity of Galpha(o)., [RefSeq, PubMed]; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q17QB5;Q6XZP9", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008289 lipid binding;GO:0001786 phosphatidylserine binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0035727 lysophosphatidic acid binding", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0016198 axon choice point recognition;GO:0040008 regulation of growth;GO:0042246 tissue regeneration;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P06836-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02666-1", "uniprot_id": [ { "id": "CASB_BOVIN", "url": "https://www.uniprot.org/uniprot/P02666", "type": "external" } ], "mass": 25107.0, "length": 224, "protein_name": "Beta-casein", "gene_name": "CSN2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CSN2", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-casein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281099)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10690361;11529896;11678861;14714726;15545057;16083266;16624358;17510049;17517096;17720176;1804413;2833669;3271384;3278933;34019948;3814153;3900695;41018975;4411121;4557764;4997616;5064450;6397405;6897774;7496485;7600458;8248100", "class_list": "", "function": "Antioxidant peptide has antioxidant activity., [UniProtKB]; Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A., [UniProtKB]; Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide., [UniProtKB]; Important role in determination of the surface properties of the casein micelles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1YQZ8;A6N8V0;Q2TA13;Q5EEQ6;Q5EEQ7;Q6UN63;Q9BDG5;Q9TSD5", "ec_number_list": [], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0005509 calcium ion binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0005576 extracellular region", "go_biological_process": "GO:0008217 regulation of blood pressure;GO:0050728 negative regulation of inflammatory response;GO:0032570 response to progesterone;GO:0032355 response to estradiol;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P02666-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2M2T7-1", "uniprot_id": [ { "id": "RT24_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2M2T7", "type": "external" } ], "mass": 19079.0, "length": 167, "protein_name": "Small ribosomal subunit protein uS3m", "gene_name": "MRPS24", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein uS3m precursor", "refseq_ac": [ { "id": "NP_001040066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040066", "type": "external" } ], "gene_names_uniprotkb": "MRPS24", "gene_names_refseq": "MRPS24", "protein_names_uniprotkb": "Small ribosomal subunit protein uS3m; 28S ribosomal protein S24, mitochondrial; MRP-S24; S24mt", "protein_names_refseq": "28S ribosomal protein S24, mitochondrial; MRP-S24; S24mt; small ribosomal subunit protein uS3m precursor; small ribosomal subunit protein uS3m", "tax_id": 9913, "disease": "", "pathway": " (bta:617466); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10938081;11402041;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P82667;Q7M367", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2M2T7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63099-1", "uniprot_id": [ { "id": "CANB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P63099", "type": "external" } ], "mass": 19300.0, "length": 170, "protein_name": "Calcineurin subunit B type 1", "gene_name": "PPP3R1", "organism": "Bovine", "refseq_name": "calcineurin subunit B type 1", "refseq_ac": [ { "id": "NP_777008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777008", "type": "external" } ], "gene_names_uniprotkb": "PPP3R1; CNA2; CNB", "gene_names_refseq": "PPP3R1", "protein_names_uniprotkb": "Calcineurin subunit B type 1; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1", "protein_names_refseq": "calcineurin B; calcineurin subunit B type 1; protein phosphatase 2B regulatory subunit 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282321); (R-BTA-111447); (R-BTA-2025928); (R-BTA-2871809); (R-BTA-4086398); (R-BTA-5607763)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "16411749;1715244;293720;6321184;7543369;7803816", "class_list": "", "function": "Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P06705;P15117;Q08044", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019902 phosphatase binding;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity;GO:0019904 protein domain specific binding;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0042383 sarcolemma;GO:0005955 calcineurin complex;GO:0098978 glutamatergic synapse;GO:0098794 postsynapse", "go_biological_process": "GO:0033173 calcineurin-NFAT signaling cascade;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0099170 postsynaptic modulation of chemical synaptic transmission;GO:0098693 regulation of synaptic vesicle cycle;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P63099-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBR2-1", "uniprot_id": [ { "id": "RM20_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBR2", "type": "external" } ], "mass": 17535.0, "length": 149, "protein_name": "Large ribosomal subunit protein bL20m", "gene_name": "MRPL20", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein bL20m precursor", "refseq_ac": [ { "id": "NP_001033595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033595", "type": "external" } ], "gene_names_uniprotkb": "MRPL20", "gene_names_refseq": "MRPL20", "protein_names_uniprotkb": "Large ribosomal subunit protein bL20m; 39S ribosomal protein L20, mitochondrial; L20mt; MRP-L20", "protein_names_refseq": "39S ribosomal protein L20, mitochondrial; L20mt; MRP-L20; large ribosomal subunit protein bL20m precursor; large ribosomal subunit protein bL20m", "tax_id": 9913, "disease": "", "pathway": " (bta:506358); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11279069;16510155;20601428", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2TBR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C2B8-1", "uniprot_id": [ { "id": "RM55_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C2B8", "type": "external" } ], "mass": 15008.0, "length": 126, "protein_name": "Large ribosomal subunit protein mL55", "gene_name": "MRPL55", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MRPL55", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein mL55; 39S ribosomal protein L55, mitochondrial; L55mt; MRP-L55", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:506657); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "11551941", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C2B8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PC3-1", "uniprot_id": [ { "id": "RM27_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32PC3", "type": "external" } ], "mass": 16034.0, "length": 148, "protein_name": "Large ribosomal subunit protein bL27m", "gene_name": "MRPL27", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein bL27m precursor", "refseq_ac": [ { "id": "NP_001032530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032530", "type": "external" } ], "gene_names_uniprotkb": "MRPL27", "gene_names_refseq": "MRPL27", "protein_names_uniprotkb": "Large ribosomal subunit protein bL27m; 39S ribosomal protein L27, mitochondrial; L27mt; MRP-L27", "protein_names_refseq": "39S ribosomal protein L27, mitochondrial; L27mt; MRP-L27; large ribosomal subunit protein bL27m precursor; large ribosomal subunit protein bL27m", "tax_id": 9913, "disease": "", "pathway": " (bta:510058); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279069;16510155", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q32PC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJJ1-1", "uniprot_id": [ { "id": "RM28_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJJ1", "type": "external" } ], "mass": 30040.0, "length": 256, "protein_name": "Large ribosomal subunit protein bL28m", "gene_name": "MRPL28", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein bL28m precursor", "refseq_ac": [ { "id": "NP_001039461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039461", "type": "external" } ], "gene_names_uniprotkb": "MRPL28", "gene_names_refseq": "MRPL28", "protein_names_uniprotkb": "Large ribosomal subunit protein bL28m; 39S ribosomal protein L28, mitochondrial; L28mt; MRP-L28", "protein_names_refseq": "39S ribosomal protein L28, mitochondrial; L28mt; MRP-L28; large ribosomal subunit protein bL28m precursor; large ribosomal subunit protein bL28m", "tax_id": 9913, "disease": "", "pathway": " (bta:508216); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11551941;20601428", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2HJJ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61763-1", "uniprot_id": [ { "id": "STXB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P61763", "type": "external" } ], "mass": 67569.0, "length": 594, "protein_name": "Syntaxin-binding protein 1", "gene_name": "STXBP1", "organism": "Bovine", "refseq_name": "syntaxin-binding protein 1", "refseq_ac": [ { "id": "NP_777044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777044", "type": "external" } ], "gene_names_uniprotkb": "STXBP1; UNC18A", "gene_names_refseq": "STXBP1; Unc18-1", "protein_names_uniprotkb": "Syntaxin-binding protein 1; N-Sec1; Protein unc-18 homolog 1; Protein unc-18 homolog A; Unc-18A; Unc18-1; p67", "protein_names_refseq": "N-Sec1; p67; protein unc-18 homolog 1; protein unc-18 homolog A; syntaxin-binding protein 1; unc-18 homolog; unc-18-1; unc-18A", "tax_id": 9913, "disease": "", "pathway": " (bta:282378); (R-BTA-181429); (R-BTA-181430); (R-BTA-210500); (R-BTA-212676); (R-BTA-264642); (R-BTA-888590)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "22039235;8247129", "class_list": "", "function": "Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q28208;Q62759;Q64320;Q96TG8", "ec_number_list": [], "go_molecular_function": "GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0098793 presynapse", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0099525 presynaptic dense core vesicle exocytosis;GO:1903305 regulation of regulated secretory pathway;GO:0006904 vesicle docking involved in exocytosis;GO:0007412 axon target recognition", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61763-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46385-1", "uniprot_id": [ { "id": "SVIL_BOVIN", "url": "https://www.uniprot.org/uniprot/O46385", "type": "external" } ], "mass": 244892.0, "length": 2194, "protein_name": "Supervillin", "gene_name": "SVIL", "organism": "Bovine", "refseq_name": "supervillin", "refseq_ac": [ { "id": "NP_776615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776615", "type": "external" } ], "gene_names_uniprotkb": "SVIL", "gene_names_refseq": "SVIL", "protein_names_uniprotkb": "Supervillin; Archvillin; p205/p250", "protein_names_refseq": "archvillin; p205/p250; supervillin", "tax_id": 9913, "disease": "", "pathway": " (bta:281509)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12202484;12917436;16880273;17925381;20309963;9382871", "class_list": "", "function": "Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. In addition to its cytoskeletal activities, acts as a cofactor or scaffold for KDM1A, facilitating H3K9me2 demethylation and promoting gene activation, especially in neuronal contexts., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Supervillin (SV)--a peripheral membrane protein that binds myosin II and F-actin in such cells--negatively regulates stress fibers, focal adhesions, and cell-substrate adhesion, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0002102 podosome;GO:0032154 cleavage furrow;GO:0030496 midbody;GO:0042995 cell projection", "go_biological_process": "GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0051014 actin filament severing;GO:0032467 positive regulation of cytokinesis;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O46385-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B79-1", "uniprot_id": [ { "id": "DHX36_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B79", "type": "external" } ], "mass": 114826.0, "length": 1010, "protein_name": "ATP-dependent DNA/RNA helicase DHX36", "gene_name": "DHX36", "organism": "Bovine", "refseq_name": "ATP-dependent DNA/RNA helicase DHX36", "refseq_ac": [ { "id": "NP_001073720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073720", "type": "external" } ], "gene_names_uniprotkb": "DHX36", "gene_names_refseq": "DHX36; G4R1", "protein_names_uniprotkb": "ATP-dependent DNA/RNA helicase DHX36; 3.6.4.12; 3.6.4.13; DEAD/H box polypeptide 36; DEAH-box protein 36; G4-resolvase-1; G4R1; MLE-like protein 1; RNA helicase associated with AU-rich element protein", "protein_names_refseq": "ATP-dependent DNA/RNA helicase DHX36; ATP-dependent RNA helicase DHX36; DEAD/H box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH-box protein 36; G4-resolvase-1; MLE-like protein 1; RNA helicase associated with AU-rich element protein", "tax_id": 9913, "disease": "", "pathway": " (bta:509583); (R-BTA-3134963)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19393038;29899445", "class_list": "", "function": "Co-crystal structure of bovine DHX36 bound to a DNA with a G-quadruplex and a 3' single-stranded DNA segment; the N-terminal DHX36-specific motif folds into a DNA-binding-induced alpha-helix that, together with the OB-fold-like subdomain, selectively binds parallel G-quadruplexes, [RefSeq, PubMed]; Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:29899445). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (By similarity). G4 structures correspond to helical structures containing guanine tetrads (PubMed:29899445). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA) (By similarity) (PubMed:29899445). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (By similarity). Plays a role in transcriptional regulation. Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (By similarity). Plays a role in post-transcriptional regulation. Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (By similarity). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (By similarity). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (By similarity). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (By similarity). Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (By similarity). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for the early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0032727 positive regulation of interferon-alpha production;GO:2000767 positive regulation of cytoplasmic translation;GO:0051891 positive regulation of cardioblast differentiation;GO:1904582 positive regulation of intracellular mRNA localization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q05B79-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T0L3-1", "uniprot_id": [ { "id": "RM17_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T0L3", "type": "external" } ], "mass": 19746.0, "length": 172, "protein_name": "Large ribosomal subunit protein bL17m", "gene_name": "MRPL17", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein bL17m precursor", "refseq_ac": [ { "id": "NP_001029446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029446", "type": "external" } ], "gene_names_uniprotkb": "MRPL17", "gene_names_refseq": "MRPL17", "protein_names_uniprotkb": "Large ribosomal subunit protein bL17m; 39S ribosomal protein L17, mitochondrial; L17mt; MRP-L17", "protein_names_refseq": "39S ribosomal protein L17, mitochondrial; L17mt; MRP-L17; large ribosomal subunit protein bL17m precursor; large ribosomal subunit protein bL17m", "tax_id": 9913, "disease": "", "pathway": " (bta:506988); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10593885;16510155", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0003964 RNA-directed DNA polymerase activity", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3T0L3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28205-1", "uniprot_id": [ { "id": "TBCD_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28205", "type": "external" } ], "mass": 133014.0, "length": 1199, "protein_name": "Tubulin-specific chaperone D", "gene_name": "TBCD", "organism": "Bovine", "refseq_name": "tubulin-specific chaperone D", "refseq_ac": [ { "id": "NP_776619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776619", "type": "external" } ], "gene_names_uniprotkb": "TBCD", "gene_names_refseq": "TBCD", "protein_names_uniprotkb": "Tubulin-specific chaperone D; Beta-tubulin cofactor D; Tubulin-folding cofactor D", "protein_names_refseq": "beta-tubulin cofactor D; tubulin-specific chaperone D", "tax_id": 9913, "disease": "", "pathway": " (bta:281515)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12912990;17704193;18171676;20740604;8706133", "class_list": "", "function": "Cofactor D functions as a centrosomal protein and is required for the recruitment of the gamma-tubulin ring complex at centrosomes and organization of the mitotic spindle, [RefSeq, PubMed]; Data show that bovine and human TBCD have functionally identical roles in tubulin heterodimer assembly, and that the inability of human TBCD to disrupt microtubule integrity can be overcome by siRNA-mediated suppression of expression of Arl2., [RefSeq, PubMed]; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006457 protein folding;GO:0070830 bicellular tight junction assembly;GO:0000226 microtubule cytoskeleton organization;GO:0010812 negative regulation of cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q28205-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10279-1", "uniprot_id": [ { "id": "PRIO_BOVIN", "url": "https://www.uniprot.org/uniprot/P10279", "type": "external" } ], "mass": 28614.0, "length": 264, "protein_name": "Major prion protein", "gene_name": "PRNP", "organism": "Bovine", "refseq_name": "major prion protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_001258555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258555", "type": "external" } ], "gene_names_uniprotkb": "PRNP; PRP", "gene_names_refseq": "AltPrP; PRNP; PrP; prn", "protein_names_uniprotkb": "Major prion protein; Major scrapie-associated fibril protein 1; PrP", "protein_names_refseq": "alternative prion protein; major prion protein isoform 1 precursor; major prion protein; major scrapie-associated fibril protein 1; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein PrP; prion protein precursor PrP", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9609523)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10899999;11531705;1362024;14687883;14722726;15477588;15554701;16460908;1671225;16962610;17270205;17896076;18625065;23098297;27606840;2904126;29262866;30555062;31511544;35151978;8440932;9363892", "class_list": "", "function": "Data suggest that the E211K prion protein provides the opportunity for future analysis of physiological changes over time. Publication Status: Online-Only, [RefSeq, PubMed]; Deletion/insertion polymorphisms of the PRNP gene is associated with bovine spongiformencephalopathy., [RefSeq, PubMed]; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Post-transcriptional silencing of Bos taurus prion family genes and its impact on granulosa cell steroidogenesis., [RefSeq, PubMed]; Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma. Publication Status: Online-Only, [RefSeq, PubMed]; The data indicate a four-rung beta-solenoid structure as a key feature for the architecture of infectious mammalian prions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1YVV9;Q01880;Q0VD57;Q5UJJ5;Q5UJM6;Q5UK69;Q5UK71;Q6UL03;Q6UL04;Q6UL05;Q6UL06;Q7YRN3;Q8MJI7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005507 copper ion binding;GO:0002151 G-quadruplex RNA binding;GO:0140693 molecular condensate scaffold activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0098552 side of membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0050850 positive regulation of calcium-mediated signaling;GO:0071280 cellular response to copper ion;GO:1900449 regulation of glutamate receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P10279-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18973-1", "uniprot_id": [ { "id": "RABX5_BOVIN", "url": "https://www.uniprot.org/uniprot/O18973", "type": "external" } ], "mass": 57009.0, "length": 492, "protein_name": "Rab5 GDP/GTP exchange factor", "gene_name": "RABGEF1", "organism": "Bovine", "refseq_name": "rab5 GDP/GTP exchange factor", "refseq_ac": [ { "id": "NP_777016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777016", "type": "external" } ], "gene_names_uniprotkb": "RABGEF1; RABEX5", "gene_names_refseq": "RABEX5; RABGEF1", "protein_names_uniprotkb": "Rab5 GDP/GTP exchange factor; Rabex-5", "protein_names_refseq": "RAB guanine nucleotide exchange factor (GEF) 1; Rab5 guanine nucleotide exchange factor Rabex-5; rab5 GDP/GTP exchange factor; rabex-5", "tax_id": 9913, "disease": "", "pathway": " (bta:282335)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15331762;16407276;16462746;17699593;18772883;22705550;9323142", "class_list": "", "function": "Acts as a guanine-nucleotide releasing factor (GEF) for RAB5A by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP. Forms a complex with RABEP1 that acts as Rab4/Rab5 effector regulating endosome fusion. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Also functions as a ubiquitin ligase., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Data show that ubiquitin binding is essential for the recruitment of Rabex-5 from the cytosol to endosomes, independently of its guanine nucleotide exchange factor activity and of Rab5., [RefSeq, PubMed]; Rabex-5 can target to early endosomes via the EET domain and activate Rab5 in a Rabaptin-5-independent manner in vivo., [RefSeq, PubMed]; Rabex-5 is a ubiquitin ligase that binds ubiquitin and undergoes ubiquitination; the N-terminal region of Rabex-5 (residues 1-76) is important for ubiquitin binding and ubiquitination., [RefSeq, PubMed]; Receptor recycling is mediated by AP-1/clathrin-coated vesicles and regulated by rab4 and rabaptin-5/rabex-5., [RefSeq, PubMed]; The structure of the N-terminal portion of Rabex-5 bound to ubiquitin at 2.5-A resolution shows that Rabex-5-ubiquitin interactions occur at two sites, [RefSeq, PubMed]; These data suggest differential physiological roles of the two ubiquitin binding domains in Rabex-5., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0030139 endocytic vesicle;GO:0030425 dendrite", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0006612 protein targeting to membrane;GO:0016197 endosomal transport;GO:0098935 dendritic transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O18973-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04467-1", "uniprot_id": [ { "id": "CALB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P04467", "type": "external" } ], "mass": 29964.0, "length": 261, "protein_name": "Calbindin", "gene_name": "CALB1", "organism": "Bovine", "refseq_name": "calbindin", "refseq_ac": [ { "id": "NP_001069663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069663", "type": "external" } ], "gene_names_uniprotkb": "CALB1", "gene_names_refseq": "CALB1", "protein_names_uniprotkb": "Calbindin; Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type", "protein_names_refseq": "D-28K; calbindin 1, 28kDa; calbindin D28; calbindin; vitamin D-dependent calcium-binding protein, avian-type", "tax_id": 9913, "disease": "", "pathway": " (bta:539930)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12438114;3754823", "class_list": "", "function": "Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Calbindin D28K is expressed by the cell membrane in bovine chromaffin cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZA2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005499 vitamin D binding;GO:0099567 calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration;GO:0099534 calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0007614 short-term memory;GO:0010842 retina layer formation;GO:0007616 long-term memory;GO:0072205 metanephric collecting duct development;GO:0035502 metanephric part of ureteric bud development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P04467-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ81-1", "uniprot_id": [ { "id": "AP1M1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ81", "type": "external" } ], "mass": 48587.0, "length": 423, "protein_name": "AP-1 complex subunit mu-1", "gene_name": "AP1M1", "organism": "Bovine", "refseq_name": "AP-1 complex subunit mu-1", "refseq_ac": [ { "id": "NP_001039349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039349", "type": "external" } ], "gene_names_uniprotkb": "AP1M1", "gene_names_refseq": "AP1M1", "protein_names_uniprotkb": "AP-1 complex subunit mu-1; AP-mu chain family member mu1A; Adaptor protein complex AP-1 subunit mu-1; Adaptor-related protein complex 1 subunit mu-1; Clathrin assembly protein complex 1 mu-1 medium chain 1; Golgi adaptor HA1/AP1 adaptin mu-1 subunit; Mu-adaptin 1; Mu1A-adaptin", "protein_names_refseq": "AP-1 complex subunit mu-1; AP-mu chain family member mu1A; adapter-related protein complex 1 subunit mu-1; adaptor protein complex AP-1 mu-1 subunit; adaptor protein complex AP-1 subunit mu-1; adaptor related protein complex 1 mu 1 subunit; clathrin assembly protein complex 1 medium chain 1; clathrin assembly protein complex 1 mu-1 medium chain 1; golgi adaptor HA1/AP1 adaptin mu-1 subunit; mu-adaptin 1; mu1A-adaptin", "tax_id": 9913, "disease": "", "pathway": " (bta:504310); (R-BTA-2132295); (R-BTA-432720); (R-BTA-432722); (R-BTA-6798695)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "12604586", "class_list": "", "function": "Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005802 trans-Golgi network;GO:0030121 AP-1 adaptor complex;GO:0045202 synapse;GO:0030665 clathrin-coated vesicle membrane;GO:0030131 clathrin adaptor complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006896 Golgi to vacuole transport;GO:0016192 vesicle-mediated transport;GO:0032438 melanosome organization;GO:0035646 endosome to melanosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KJ81-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02675-1", "uniprot_id": [ { "id": "DPYL2_BOVIN", "url": "https://www.uniprot.org/uniprot/O02675", "type": "external" } ], "mass": 62278.0, "length": 572, "protein_name": "Dihydropyrimidinase-related protein 2", "gene_name": "DPYSL2", "organism": "Bovine", "refseq_name": "dihydropyrimidinase-related protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001069468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069468", "type": "external" } ], "gene_names_uniprotkb": "DPYSL2", "gene_names_refseq": "CRMP-2; DPYSL2; DRP-2; TOAD-64", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 2; DRP-2; Neural-specific protein NSP60", "protein_names_refseq": "collapsin response mediator protein 2; dihydropyrimidinase-related protein 2 isoform 2; dihydropyrimidinase-related protein 2; neural-specific protein NSP60; turned on after division 64", "tax_id": 9913, "disease": "", "pathway": " (bta:533746); (R-BTA-399956)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10818093;20801876", "class_list": "", "function": "Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q29RI7", "ec_number_list": [], "go_molecular_function": "GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0019901 protein kinase binding;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0120025 plasma membrane bounded cell projection;GO:0014069 postsynaptic density", "go_biological_process": "GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O02675-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63315-1", "uniprot_id": [ { "id": "TNNC1_BOVIN", "url": "https://www.uniprot.org/uniprot/P63315", "type": "external" } ], "mass": 18417.0, "length": 161, "protein_name": "Troponin C, slow skeletal and cardiac muscles", "gene_name": "TNNC1", "organism": "Bovine", "refseq_name": "troponin C, slow skeletal and cardiac muscles", "refseq_ac": [ { "id": "NP_001029523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029523", "type": "external" } ], "gene_names_uniprotkb": "TNNC1; TNNC", "gene_names_refseq": "TNNC1", "protein_names_uniprotkb": "Troponin C, slow skeletal and cardiac muscles; TN-C", "protein_names_refseq": "TN-C; troponin C type 1 (slow); troponin C, slow skeletal and cardiac muscles", "tax_id": 9913, "disease": "", "pathway": " (bta:509486); (R-BTA-390522)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1252434;18285522", "class_list": "", "function": "These results demonstrate that the L29Q mutation enhances the Ca(2+)-binding characteristics of cTnC and that when incorporated into cardiac myocytes, this mutant alters myocyte contractility., [RefSeq, PubMed]; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O14800;P02590;P04463;Q3SZB2", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0031013 troponin I binding;GO:0008092 cytoskeletal protein binding;GO:0031014 troponin T binding", "go_cellular_component": "GO:1990584 cardiac Troponin complex;GO:0097512 cardiac myofibril", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0060048 cardiac muscle contraction;GO:0086003 cardiac muscle cell contraction;GO:0055010 ventricular cardiac muscle tissue morphogenesis;GO:0032972 regulation of muscle filament sliding speed", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P63315-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15467-1", "uniprot_id": [ { "id": "RNAS4_BOVIN", "url": "https://www.uniprot.org/uniprot/P15467", "type": "external" } ], "mass": 16938.0, "length": 147, "protein_name": "Ribonuclease 4", "gene_name": "RNASE4", "organism": "Bovine", "refseq_name": "ribonuclease 4 precursor", "refseq_ac": [ { "id": "NP_001035680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035680", "type": "external" } ], "gene_names_uniprotkb": "RNASE4; ANG; RNS4", "gene_names_refseq": "RNASE4", "protein_names_uniprotkb": "Ribonuclease 4; 3.1.27.-; RNase 4; Ribonuclease BL4", "protein_names_refseq": "RNase 4; ribonuclease 4 precursor; ribonuclease 4; ribonuclease BL4; ribonuclease, RNase A family, 4", "tax_id": 9913, "disease": "", "pathway": " (bta:616089)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16305752;2358434", "class_list": "", "function": "Cleaves preferentially after uridine bases. Has antimicrobial activity against uropathogenic E.coli (UPEC). Probably contributes to urinary tract sterility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1N6N1;Q3T184;Q58DP6;Q9TV33", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region;GO:0005730 nucleolus", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P15467-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62261-1", "uniprot_id": [ { "id": "1433E_BOVIN", "url": "https://www.uniprot.org/uniprot/P62261", "type": "external" } ], "mass": 29174.0, "length": 255, "protein_name": "14-3-3 protein epsilon", "gene_name": "YWHAE", "organism": "Bovine", "refseq_name": "14-3-3 protein epsilon", "refseq_ac": [ { "id": "NP_776916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776916", "type": "external" } ], "gene_names_uniprotkb": "YWHAE", "gene_names_refseq": "YWHAE", "protein_names_uniprotkb": "14-3-3 protein epsilon; 14-3-3E", "protein_names_refseq": "14-3-3 protein epsilon; 14-3-3E; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide", "tax_id": 9913, "disease": "", "pathway": " (bta:282125); (R-BTA-111447); (R-BTA-2028269); (R-BTA-205025); (R-BTA-2565942); (R-BTA-3371453); (R-BTA-3371511); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-5625740); (R-BTA-5628897); (R-BTA-75035); (R-BTA-8854518); (R-BTA-8876198)", "pathway_count": 17, "publication_count": 1, "publication_id_list": "7931346", "class_list": "", "function": "Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:7931346). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:7931346). Binding generally results in the modulation of the activity of the binding partner (PubMed:7931346). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P29360;P42655;Q3ZC40;Q63631", "ec_number_list": [], "go_molecular_function": "GO:0050815 phosphoserine residue binding;GO:0050816 phosphothreonine residue binding;GO:0019904 protein domain specific binding;GO:0019903 protein phosphatase binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042470 melanosome", "go_biological_process": "GO:0007165 signal transduction;GO:0000165 MAPK cascade;GO:0034605 cellular response to heat;GO:0046827 positive regulation of protein export from nucleus;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62261-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T035-1", "uniprot_id": [ { "id": "ARPC3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T035", "type": "external" } ], "mass": 20547.0, "length": 178, "protein_name": "Actin-related protein 2/3 complex subunit 3", "gene_name": "ARPC3", "organism": "Bovine", "refseq_name": "actin-related protein 2/3 complex subunit 3", "refseq_ac": [ { "id": "NP_001029443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029443", "type": "external" } ], "gene_names_uniprotkb": "ARPC3", "gene_names_refseq": "ARPC3", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 3; Arp2/3 complex 21 kDa subunit; p21-ARC", "protein_names_refseq": "actin related protein 2/3 complex, subunit 3, 21kDa; actin-related protein 2/3 complex subunit 3; arp2/3 complex 21 kDa subunit; p21-ARC", "tax_id": 9913, "disease": "", "pathway": " (bta:506596); (R-BTA-2029482); (R-BTA-3928662); (R-BTA-5663213); (R-BTA-8856828)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "11721045;15505213;23893131", "class_list": "", "function": "Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks., [UniProtKB, UniProtKB]; The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0005885 Arp2/3 protein complex", "go_biological_process": "GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0030833 regulation of actin filament polymerization;GO:1900242 regulation of synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3T035-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ54-1", "uniprot_id": [ { "id": "PIPNA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ54", "type": "external" } ], "mass": 31849.0, "length": 270, "protein_name": "Phosphatidylinositol transfer protein alpha isoform", "gene_name": "PITPNA", "organism": "Bovine", "refseq_name": "phosphatidylinositol transfer protein alpha isoform", "refseq_ac": [ { "id": "NP_001040047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040047", "type": "external" } ], "gene_names_uniprotkb": "PITPNA", "gene_names_refseq": "PITPNA", "protein_names_uniprotkb": "Phosphatidylinositol transfer protein alpha isoform; PI-TP 35 kda isoform; PI-TP-alpha; Phosphatidylinositol-transfer protein 35 kDa isoform; PtdIns transfer protein alpha; PtdInsTP alpha", "protein_names_refseq": "PI-TP-alpha; phosphatidylinositol transfer protein alpha isoform; ptdIns transfer protein alpha; ptdInsTP alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:616550)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7654206", "class_list": "", "function": "Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:7654206). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (By similarity). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions. Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9TR37", "ec_number_list": [], "go_molecular_function": "GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding;GO:0008526 phosphatidylinositol transfer activity;GO:0008525 phosphatidylcholine transporter activity;GO:0120019 phosphatidylcholine transfer activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007409 axonogenesis;GO:0061024 membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2HJ54-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P569-1", "uniprot_id": [ { "id": "NUCB1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P569", "type": "external" } ], "mass": 54982.0, "length": 474, "protein_name": "Nucleobindin-1", "gene_name": "NUCB1", "organism": "Bovine", "refseq_name": "nucleobindin-1 precursor", "refseq_ac": [ { "id": "NP_001068667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068667", "type": "external" } ], "gene_names_uniprotkb": "NUCB1", "gene_names_refseq": "NUCB1", "protein_names_uniprotkb": "Nucleobindin-1", "protein_names_refseq": "nucleobindin-1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:505351); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "7890746", "class_list": "", "function": "Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (PubMed:7890746). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity)., [UniProtKB, PubMed, UniProtKB]; Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005509 calcium ion binding;GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0000139 Golgi membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0P569-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02318-1", "uniprot_id": [ { "id": "HSP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P02318", "type": "external" } ], "mass": 6758.0, "length": 51, "protein_name": "Sperm protamine P1", "gene_name": "PRM1", "organism": "Bovine", "refseq_name": "sperm protamine P1", "refseq_ac": [ { "id": "NP_776581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776581", "type": "external" } ], "gene_names_uniprotkb": "PRM1; PRM-1", "gene_names_refseq": "PRM1", "protein_names_uniprotkb": "Sperm protamine P1; Cysteine-rich protamine", "protein_names_refseq": "cysteine-rich protamine; sperm protamine P1", "tax_id": 9913, "disease": "", "pathway": " (bta:281423)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12912999;1988019;23044178;2436637;3335501;3730390;3829889;4675900", "class_list": "", "function": "Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex., [UniProtKB]; The number of clustered arginine residues present in the DNA binding domain is the most important factor affecting the condensation and stability of the DNA-protamine complex prior to the formation of inter-protamine disulfide cross-links., [RefSeq, PubMed]; This study was conducted to isolate high-quality RNA from mature spermatozoa and to monitor the expression profile of PRM1 and PRM2 gene in ejaculated spermatozoa of normal and motility impaired bulls., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0030261 chromosome condensation;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P02318-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23004-1", "uniprot_id": [ { "id": "QCR2_BOVIN", "url": "https://www.uniprot.org/uniprot/P23004", "type": "external" } ], "mass": 48149.0, "length": 453, "protein_name": "Cytochrome b-c1 complex subunit 2, mitochondrial", "gene_name": "UQCRC2", "organism": "Bovine", "refseq_name": "cytochrome b-c1 complex subunit 2, mitochondrial", "refseq_ac": [ { "id": "NP_001357536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001357536", "type": "external" } ], "gene_names_uniprotkb": "UQCRC2", "gene_names_refseq": "UQCRC2", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 2, mitochondrial; Complex III subunit 2; Core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2", "protein_names_refseq": "complex III subunit 2; core protein II; cytochrome b-c1 complex subunit 2, mitochondrial; ubiquinol-cytochrome c reductase core protein II; ubiquinol-cytochrome-c reductase complex core protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282394); (R-BTA-611105); (R-BTA-9837999); (R-BTA-9865881)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "11073949;12269811;15312779;16024040;16305752;16924113;1712295;22794312;28100784;2841307;2848575;29243944;9204897;9651245;9694818", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (PubMed:11073949, PubMed:9694818). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; ENO1, VDAC2, and UQCRC2 were significantly correlated with individual fertility in bulls., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCG7;Q5E9C7", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006508 proteolysis;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P23004-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P594-1", "uniprot_id": [ { "id": "PP2AB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P594", "type": "external" } ], "mass": 35561.0, "length": 309, "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform", "gene_name": "PPP2CB", "organism": "Bovine", "refseq_name": "serine/threonine-protein phosphatase 2A catalytic subunit beta isoform", "refseq_ac": [ { "id": "NP_001069325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069325", "type": "external" } ], "gene_names_uniprotkb": "PPP2CB", "gene_names_refseq": "PPP2CB", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; 3.1.3.16; PP2A-beta", "protein_names_refseq": "PP2A-beta; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform", "tax_id": 9913, "disease": "", "pathway": " (bta:524361); (R-BTA-113501); (R-BTA-1295596); (R-BTA-141430); (R-BTA-141444); (R-BTA-180024); (R-BTA-195253); (R-BTA-196299); (R-BTA-198753); (R-BTA-202670); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-389356); (R-BTA-389513); (R-BTA-432142); (R-BTA-4641262); (R-BTA-5663220); (R-BTA-5673000); (R-BTA-5675221); (R-BTA-6804757); (R-BTA-6811558); (R-BTA-69231); (R-BTA-69273); (R-BTA-9648025); (R-BTA-9833482)", "pathway_count": 25, "publication_count": 1, "publication_id_list": "12912990", "class_list": "", "function": "Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.1.1.233", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.233", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.89", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0P594-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DT3-1", "uniprot_id": [ { "id": "NTF3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DT3", "type": "external" } ], "mass": 28861.0, "length": 253, "protein_name": "Neurotrophin-3", "gene_name": "NTF3", "organism": "Bovine", "refseq_name": "neurotrophin-3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001071456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071456", "type": "external" } ], "gene_names_uniprotkb": "NTF3", "gene_names_refseq": "NT-3; NTF3", "protein_names_uniprotkb": "Neurotrophin-3; NT-3", "protein_names_refseq": "neurotrophin-3 isoform 1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:532393); (R-BTA-1257604); (R-BTA-6811558); (R-BTA-9034013); (R-BTA-9034793); (R-BTA-9603381)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Seems to promote the survival of visceral and proprioceptive sensory neurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding;GO:0005165 neurotrophin receptor binding;GO:0042056 chemoattractant activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0008021 synaptic vesicle;GO:0005576 extracellular region", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0048812 neuron projection morphogenesis;GO:0043524 negative regulation of neuron apoptotic process;GO:0050804 modulation of chemical synaptic transmission;GO:0021675 nerve development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DT3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00426-1", "uniprot_id": [ { "id": "COX5A_BOVIN", "url": "https://www.uniprot.org/uniprot/P00426", "type": "external" } ], "mass": 16735.0, "length": 152, "protein_name": "Cytochrome c oxidase subunit 5A, mitochondrial", "gene_name": "COX5A", "organism": "Bovine", "refseq_name": "cytochrome c oxidase subunit 5A, mitochondrial", "refseq_ac": [ { "id": "NP_001422038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422038", "type": "external" } ], "gene_names_uniprotkb": "COX5A", "gene_names_refseq": "COX5A", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 5A, mitochondrial; Cytochrome c oxidase polypeptide Va", "protein_names_refseq": "cytochrome c oxidase polypeptide Va; cytochrome c oxidase subunit 5A, mitochondrial; cytochrome c oxidase subunit Va; mitochondrial cytochrome c oxidase subunit 5a", "tax_id": 9913, "disease": "", "pathway": " (bta:444878); (R-BTA-5628897); (R-BTA-611105); (R-BTA-9707564); (R-BTA-9837999); (R-BTA-9864848)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "10089392;10771420;20385840;220224;26698328;27605664;28100784;2844245;31533957;8638158", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32LF6;Q6QRN2", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P00426-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13620-1", "uniprot_id": [ { "id": "ATP5H_BOVIN", "url": "https://www.uniprot.org/uniprot/P13620", "type": "external" } ], "mass": 18692.0, "length": 161, "protein_name": "ATP synthase peripheral stalk subunit d, mitochondrial", "gene_name": "ATP5PD", "organism": "Bovine", "refseq_name": "ATP synthase peripheral stalk subunit d, mitochondrial", "refseq_ac": [ { "id": "NP_777149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777149", "type": "external" } ], "gene_names_uniprotkb": "ATP5PD; ATP5H", "gene_names_refseq": "ATP5H; ATP5PD", "protein_names_uniprotkb": "ATP synthase peripheral stalk subunit d, mitochondrial; ATP synthase peripheral stalk subunit d; ATPase subunit d", "protein_names_refseq": "ATP synthase peripheral stalk subunit d, mitochondrial; ATP synthase subunit d, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d; ATP synthase, H+ transporting, mitochondrial Fo complex subunit D; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d; ATPase subunit d", "tax_id": 9913, "disease": "", "pathway": " (bta:282710); (R-BTA-163210); (R-BTA-8949613); (R-BTA-9837999)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "17570365;25851905;28100784;2890767", "class_list": "", "function": "Subunit d, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (Probable)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SX10", "ec_number_list": [], "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P13620-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08239-1", "uniprot_id": [ { "id": "GNAO_BOVIN", "url": "https://www.uniprot.org/uniprot/P08239", "type": "external" } ], "mass": 40067.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein G(o) subunit alpha", "gene_name": "GNAO1", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(o) subunit alpha", "refseq_ac": [ { "id": "NP_776750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776750", "type": "external" } ], "gene_names_uniprotkb": "GNAO1", "gene_names_refseq": "GNAO1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(o) subunit alpha; 3.6.5.-; GTP-binding protein G39", "protein_names_refseq": "GTP-binding protein G39; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide-binding protein G(o) subunit alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:281792); (R-BTA-4086398)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19146979;3090546;3106961;3113429;3121394;8654559", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (By similarity). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase (By similarity). Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity)., [UniProtKB, UniProtKB]; These results indicated the interaction of GAP-43 and Galpha(o) could accelerate conversion of depalmitoylated Galpha(o) but not palmitoylated Galpha(o) from oligomers to monomers, so as to increase the GTPgammaS binding activity of Galpha(o)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJS0", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0031821 G protein-coupled serotonin receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005834 heterotrimeric G-protein complex;GO:0016020 membrane", "go_biological_process": "GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007212 G protein-coupled dopamine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P08239-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28862-1", "uniprot_id": [ { "id": "SIAL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28862", "type": "external" } ], "mass": 34101.0, "length": 310, "protein_name": "Integrin-binding sialoprotein", "gene_name": "IBSP", "organism": "Bovine", "refseq_name": "integrin-binding sialoprotein precursor", "refseq_ac": [ { "id": "NP_776509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776509", "type": "external" } ], "gene_names_uniprotkb": "IBSP", "gene_names_refseq": "IBSP", "protein_names_uniprotkb": "Integrin-binding sialoprotein; BSP II; Bone sialoprotein 2; Bone sialoprotein II; Cell-binding sialoprotein", "protein_names_refseq": "BSP II; bone sialoprotein 2; cell-binding sialoprotein; integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II); integrin-binding sialoprotein precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281233); (R-BTA-216083)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15004024;2461939;37016135;7514841;8663267", "class_list": "", "function": "Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes adhesion and migration of various cells via the alpha-V/beta-3 integrin receptor (ITGAV:ITGB3)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Genome-wide association study reveals that the IBSP locus affects ear size in cattle., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0031982 vesicle;GO:0005576 extracellular region", "go_biological_process": "GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0071363 cellular response to growth factor stimulus;GO:0030282 bone mineralization;GO:0031214 biomineral tissue development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q28862-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RK1-1", "uniprot_id": [ { "id": "CISY_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RK1", "type": "external" } ], "mass": 51773.0, "length": 466, "protein_name": "Citrate synthase, mitochondrial", "gene_name": "CS", "organism": "Bovine", "refseq_name": "citrate synthase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001038186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038186", "type": "external" } ], "gene_names_uniprotkb": "CS", "gene_names_refseq": "CS", "protein_names_uniprotkb": "Citrate synthase, mitochondrial; 2.3.3.1; Citrate (Si)-synthase", "protein_names_refseq": "citrate (Si)-synthase; citrate synthase, mitochondrial precursor; citrate synthase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:280682); (R-BTA-71403); (R-BTA-9837999); (R-BTA-9854311)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "22076378;28100784", "class_list": "", "function": "Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0036440 citrate synthase activity;GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006101 citrate metabolic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q29RK1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46162-1", "uniprot_id": [ { "id": "DEFB4_BOVIN", "url": "https://www.uniprot.org/uniprot/P46162", "type": "external" } ], "mass": 7161.0, "length": 63, "protein_name": "Beta-defensin 4", "gene_name": "DEFB4A; DEFB4", "organism": "Bovine", "refseq_name": "beta-defensin 4 precursor", "refseq_ac": [ { "id": "NP_777200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777200", "type": "external" } ], "gene_names_uniprotkb": "DEFB4A; DEFB4; BNBD4", "gene_names_refseq": "BNBD-4; BNBD4; DEFB4A; DEFB4", "protein_names_uniprotkb": "Beta-defensin 4; BNBD-4; BNDB-4", "protein_names_refseq": "BNDB-4; beta-defensin 4 precursor; defensin, beta 4; neutrophil beta-defensin 4", "tax_id": 9913, "disease": "", "pathway": " (bta:286836)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17550357;23298865;25946365;26255277;8454635", "class_list": "", "function": "Bovine DEFB4 mRNA is upregulated by lipopolysaccharide in bovine neutrophils and mammary epithelial cells and by 1,25-dihydroxyvitamin D3 in bovine monocytes and mammary epithelial cells., [RefSeq, PubMed]; Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A., [UniProtKB]; Recombinant mature bovine neutrophil beta-defensin 4 inhibits mycobacterial growth and controls intracellular survival of mycobacteria., [RefSeq, PubMed]; Stimulation of umbilical-vein endothelial cells with S. aureus or LPS induced the expression of bovine neutrophil beta-defensin 4. This expression was regulated by the autocrine production of tumor necrosis factor-alpha., [RefSeq, PubMed]; The isolation of polymorphisms of BNBD-4 and milk production and somatic cell count are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P46162-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIE6-1", "uniprot_id": [ { "id": "HMCS2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIE6", "type": "external" } ], "mass": 56895.0, "length": 508, "protein_name": "Hydroxymethylglutaryl-CoA synthase, mitochondrial", "gene_name": "HMGCS2", "organism": "Bovine", "refseq_name": "hydroxymethylglutaryl-CoA synthase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001039348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039348", "type": "external" } ], "gene_names_uniprotkb": "HMGCS2", "gene_names_refseq": "HMGCS2; hmgCoA", "protein_names_uniprotkb": "Hydroxymethylglutaryl-CoA synthase, mitochondrial; 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase; HMG-CoA synthase", "protein_names_refseq": "3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial); HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase, mitochondrial precursor; hydroxymethylglutaryl-CoA synthase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:503684); (R-BTA-77111); (R-BTA-9837999)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22076378", "class_list": "", "function": "Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA., [UniProtKB, UniProtKB]; Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004421 hydroxymethylglutaryl-CoA synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0046951 ketone body biosynthetic process;GO:0006084 acetyl-CoA metabolic process;GO:0006695 cholesterol biosynthetic process;GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KIE6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52205-1", "uniprot_id": [ { "id": "ROM1_BOVIN", "url": "https://www.uniprot.org/uniprot/P52205", "type": "external" } ], "mass": 37418.0, "length": 351, "protein_name": "Rod outer segment membrane protein 1", "gene_name": "ROM1", "organism": "Bovine", "refseq_name": "rod outer segment membrane protein 1", "refseq_ac": [ { "id": "NP_776599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776599", "type": "external" } ], "gene_names_uniprotkb": "ROM1", "gene_names_refseq": "ROM1", "protein_names_uniprotkb": "Rod outer segment membrane protein 1; ROSP1", "protein_names_refseq": "ROSP1; rod outer segment membrane protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:281465)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10681511;1610568;24196967;8603840", "class_list": "", "function": "Plays a role in rod outer segment (ROS) morphogenesis (By similarity). May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (PubMed:24196967). Plays a role in the organization of the ROS and maintenance of ROS disk diameter (By similarity). Involved in the maintenance of the retina outer nuclear layer (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17QV8;Q28926;Q95134", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001917 photoreceptor inner segment;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P52205-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48305-1", "uniprot_id": [ { "id": "NDUB4_BOVIN", "url": "https://www.uniprot.org/uniprot/P48305", "type": "external" } ], "mass": 15184.0, "length": 129, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "gene_name": "NDUFB4", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "refseq_ac": [ { "id": "NP_787016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787016", "type": "external" } ], "gene_names_uniprotkb": "NDUFB4", "gene_names_refseq": "B15; NDUFB4", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4; CI-B15; Complex I-B15; NADH-ubiquinone oxidoreductase B15 subunit", "protein_names_refseq": "CI-B15; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4; NADH-ubiquinone oxidoreductase B15 subunit; complex I-B15", "tax_id": 9913, "disease": "", "pathway": " (bta:327706)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10852722;1518044;18721790;28100784", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q54A31", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P48305-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23935-1", "uniprot_id": [ { "id": "NDUA5_BOVIN", "url": "https://www.uniprot.org/uniprot/P23935", "type": "external" } ], "mass": 13316.0, "length": 116, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "gene_name": "NDUFA5", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "refseq_ac": [ { "id": "NP_787023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787023", "type": "external" } ], "gene_names_uniprotkb": "NDUFA5", "gene_names_refseq": "B13; NDUFA5", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; CI-13kD-B; Complex I subunit B13; Complex I-13kD-B; NADH-ubiquinone oxidoreductase 13 kDa-B subunit", "protein_names_refseq": "CI-13kD-B; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; NADH-ubiquinone oxidoreductase 13 kDa-B subunit; complex I subunit B13; complex I-13kD-B", "tax_id": 9913, "disease": "", "pathway": " (bta:327714); (R-BTA-611105); (R-BTA-6799198); (R-BTA-9013408)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10852722;1518044;18721790;1907966", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32P63", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P23935-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N131-1", "uniprot_id": [ { "id": "H11_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N131", "type": "external" } ], "mass": 22100.0, "length": 218, "protein_name": "Histone H1.1", "gene_name": "H1-1", "organism": "Bovine", "refseq_name": "histone H1.1", "refseq_ac": [ { "id": "XP_010816821", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010816821", "type": "external" } ], "gene_names_uniprotkb": "H1-1; HIST1H1A", "gene_names_refseq": "H1-1", "protein_names_uniprotkb": "Histone H1.1; Histone H1a", "protein_names_refseq": "histone H1.1", "tax_id": 9913, "disease": "", "pathway": " (bta:618164)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19393038;3134256;8003976", "class_list": "", "function": "Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0009986 cell surface;GO:0031982 vesicle;GO:0000791 euchromatin", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006334 nucleosome assembly;GO:0048260 positive regulation of receptor-mediated endocytosis;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G3N131-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18979-1", "uniprot_id": [ { "id": "GNAS3_BOVIN", "url": "https://www.uniprot.org/uniprot/O18979", "type": "external" } ], "mass": 27494.0, "length": 241, "protein_name": "Neuroendocrine secretory protein 55", "gene_name": "GNAS", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GNAS; GNAS1", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuroendocrine secretory protein 55; NESP55", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281793)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10729789;15627817;9111083", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0030133 transport vesicle", "go_biological_process": "GO:0040015 negative regulation of multicellular organism growth;GO:0071107 response to parathyroid hormone", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O18979-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46469-1", "uniprot_id": [ { "id": "RGS9_BOVIN", "url": "https://www.uniprot.org/uniprot/O46469", "type": "external" } ], "mass": 56680.0, "length": 484, "protein_name": "Regulator of G protein signaling 9", "gene_name": "RGS9", "organism": "Bovine", "refseq_name": "regulator of G-protein signaling 9", "refseq_ac": [ { "id": "NP_776595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776595", "type": "external" } ], "gene_names_uniprotkb": "RGS9", "gene_names_refseq": "RGS9", "protein_names_uniprotkb": "Regulator of G protein signaling 9; RGS9", "protein_names_refseq": "regulator of G-protein signaling 9", "tax_id": 9913, "disease": "", "pathway": " (bta:281453)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10051575;11234020;12119397;33453187;9459445", "class_list": "", "function": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction., [UniProtKB]; Structural information and membrane binding of truncated RGS9-1 Anchor Protein and its C-terminal hydrophobic segment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0097381 photoreceptor disc membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007212 G protein-coupled dopamine receptor signaling pathway;GO:0007601 visual perception;GO:0009968 negative regulation of signal transduction;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O46469-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O62647-1", "uniprot_id": [ { "id": "PNOC_BOVIN", "url": "https://www.uniprot.org/uniprot/O62647", "type": "external" } ], "mass": 20256.0, "length": 176, "protein_name": "Prepronociceptin", "gene_name": "PNOC", "organism": "Bovine", "refseq_name": "prepronociceptin precursor", "refseq_ac": [ { "id": "NP_776575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776575", "type": "external" } ], "gene_names_uniprotkb": "PNOC", "gene_names_refseq": "PNOC", "protein_names_uniprotkb": "Prepronociceptin; Orphanin FQ; PPNOC", "protein_names_refseq": "nociceptin; prepronociceptin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281414); (R-BTA-375276); (R-BTA-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23264212;9521323", "class_list": "", "function": "Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia., [UniProtKB, PubMed]; Has potent analgesic activity., [UniProtKB, UniProtKB]; Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development., [UniProtKB, UniProtKB]; The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031628 opioid receptor binding;GO:0001515 opioid peptide activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007268 chemical synaptic transmission;GO:0007600 sensory perception", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O62647-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00129-1", "uniprot_id": [ { "id": "QCR7_BOVIN", "url": "https://www.uniprot.org/uniprot/P00129", "type": "external" } ], "mass": 13476.0, "length": 111, "protein_name": "Cytochrome b-c1 complex subunit 7", "gene_name": "UQCRB", "organism": "Bovine", "refseq_name": "cytochrome b-c1 complex subunit 7", "refseq_ac": [ { "id": "NP_001029969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029969", "type": "external" } ], "gene_names_uniprotkb": "UQCRB", "gene_names_refseq": "UQCRB", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 7; Complex III subunit 7; Complex III subunit VII; QP-C; Ubiquinol-cytochrome c reductase complex 14 kDa protein", "protein_names_refseq": "QP-C; complex III subunit 7; complex III subunit VII; cytochrome b-c1 complex subunit 7; ubiquinol-cytochrome c reductase complex 14 kDa protein", "tax_id": 9913, "disease": "", "pathway": " (bta:616871); (R-BTA-611105); (R-BTA-9865881)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12269811;15312779;16024040;16924113;28100784;2981208;9204897;9651245", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZ83", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P00129-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00428-1", "uniprot_id": [ { "id": "COX5B_BOVIN", "url": "https://www.uniprot.org/uniprot/P00428", "type": "external" } ], "mass": 13834.0, "length": 129, "protein_name": "Cytochrome c oxidase subunit 5B, mitochondrial", "gene_name": "COX5B", "organism": "Bovine", "refseq_name": "cytochrome c oxidase subunit 5B, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001029218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029218", "type": "external" } ], "gene_names_uniprotkb": "COX5B", "gene_names_refseq": "COX5B", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 5B, mitochondrial; Cytochrome c oxidase polypeptide VIa; Cytochrome c oxidase polypeptide Vb", "protein_names_refseq": "cytochrome c oxidase polypeptide VIa; cytochrome c oxidase polypeptide Vb; cytochrome c oxidase subunit 5B, mitochondrial precursor; cytochrome c oxidase subunit 5B, mitochondrial; cytochrome c oxidase subunit Vb", "tax_id": 9913, "disease": "", "pathway": " (bta:287012)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10089392;10771420;20385840;26698328;27605664;28100784;2840351;2844245;31533957;6292069;8638158", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QL66;P11949;Q3T041", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P00428-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00732-1", "uniprot_id": [ { "id": "CBPB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P00732", "type": "external" } ], "mass": 47348.0, "length": 417, "protein_name": "Carboxypeptidase B", "gene_name": "CPB1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CPB1; CPB", "gene_names_refseq": "", "protein_names_uniprotkb": "Carboxypeptidase B; 3.4.17.2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2022377)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1057162;4565668;4833744;5344132;957425", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.17.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.2", "type": "external" }, { "id": "3.4.17.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.20", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P00732-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00744-1", "uniprot_id": [ { "id": "PROZ_BOVIN", "url": "https://www.uniprot.org/uniprot/P00744", "type": "external" } ], "mass": 43113.0, "length": 396, "protein_name": "Vitamin K-dependent protein Z", "gene_name": "PROZ", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PROZ", "gene_names_refseq": "", "protein_names_uniprotkb": "Vitamin K-dependent protein Z", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2129367;2511201;3888670", "class_list": "", "function": "Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P00744-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00847-1", "uniprot_id": [ { "id": "ATP6_BOVIN", "url": "https://www.uniprot.org/uniprot/P00847", "type": "external" } ], "mass": 24788.0, "length": 226, "protein_name": "ATP synthase F(0) complex subunit a", "gene_name": "MT-ATP6", "organism": "Bovine", "refseq_name": "ATP synthase F0 subunit 6", "refseq_ac": [ { "id": "YP_209210", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209210", "type": "external" } ], "gene_names_uniprotkb": "MT-ATP6; ATP6; ATPASE6; MTATP6", "gene_names_refseq": "ATP6", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit a; F-ATPase protein 6; Proton-conducting channel, ATP synthase F(0) complex subunit a", "protein_names_refseq": "ATP synthase F0 subunit 6", "tax_id": 9913, "disease": "", "pathway": " (bta:3283882); (R-BTA-163210); (R-BTA-5419276); (R-BTA-8949613); (R-BTA-9837999)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "17570365;2875870;7120390", "class_list": "", "function": "Subunit a, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. With the subunit c (ATP5MC1), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix. Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SFX8", "ec_number_list": [], "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism;GO:0015252 proton channel activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P00847-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01252-1", "uniprot_id": [ { "id": "PTMA_BOVIN", "url": "https://www.uniprot.org/uniprot/P01252", "type": "external" } ], "mass": 12072.0, "length": 110, "protein_name": "Prothymosin alpha", "gene_name": "PTMA", "organism": "Bovine", "refseq_name": "prothymosin alpha isoform X2", "refseq_ac": [ { "id": "XP_003585828", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585828", "type": "external" } ], "gene_names_uniprotkb": "PTMA", "gene_names_refseq": "PTMA", "protein_names_uniprotkb": "Prothymosin alpha", "protein_names_refseq": "prothymosin alpha isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:786336)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1426245;2901823;762108;8485135", "class_list": "", "function": "Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P01252-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02584-1", "uniprot_id": [ { "id": "PROF1_BOVIN", "url": "https://www.uniprot.org/uniprot/P02584", "type": "external" } ], "mass": 15057.0, "length": 140, "protein_name": "Profilin-1", "gene_name": "PFN1", "organism": "Bovine", "refseq_name": "profilin-1", "refseq_ac": [ { "id": "NP_001015592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015592", "type": "external" } ], "gene_names_uniprotkb": "PFN1", "gene_names_refseq": "PFN1", "protein_names_uniprotkb": "Profilin-1; Profilin I", "protein_names_refseq": "profilin I; profilin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:513895); (R-BTA-4086400); (R-BTA-5663220)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "16305752;16428279;16428297;16428331;19523483;30573663;3342873;446730;8046751;8413665;8918942", "class_list": "", "function": "Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity)., [UniProtKB, UniProtKB]; Biophysical analysis reveals that the open nucleotide pocket of the profilin/actin x-ray structure is unstable and closes in the absence of profilin, [RefSeq, PubMed]; Nitric oxide and free radicals produced under different conditions could alter the functions of profilin through nitration, such as its interaction with actin and poly (l-proline)., [RefSeq, PubMed]; Phosphorylation studies indicate that profilin dimers are not phosphorylated while teramers are preferentially phosphorylated over monomers., [RefSeq, PubMed]; Profilin regulates actin dynamics both within the cytoplasm and inside the nuclei of developing mammalian embryos., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCH4;Q5E942", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0030036 actin cytoskeleton organization;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P02584-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02720-1", "uniprot_id": [ { "id": "PPCT_BOVIN", "url": "https://www.uniprot.org/uniprot/P02720", "type": "external" } ], "mass": 24643.0, "length": 213, "protein_name": "Phosphatidylcholine transfer protein", "gene_name": "PCTP", "organism": "Bovine", "refseq_name": "phosphatidylcholine transfer protein", "refseq_ac": [ { "id": "NP_777260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777260", "type": "external" } ], "gene_names_uniprotkb": "PCTP; STARD2", "gene_names_refseq": "PCTP", "protein_names_uniprotkb": "Phosphatidylcholine transfer protein; PC-TP; START domain-containing protein 2; StAR-related lipid transfer protein 2; StARD2", "protein_names_refseq": "PC-TP; START domain-containing protein 2; phosphatidylcholine transfer protein; stAR-related lipid transfer protein 2; stARD2", "tax_id": 9913, "disease": "", "pathway": " (bta:317656); (R-BTA-1483191); (R-BTA-77289)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11551535;499208;7011810;7042332;7590292;8645232", "class_list": "", "function": "Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZA5", "ec_number_list": [], "go_molecular_function": "GO:0031210 phosphatidylcholine binding;GO:0008525 phosphatidylcholine transporter activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P02720-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03924-1", "uniprot_id": [ { "id": "NU6M_BOVIN", "url": "https://www.uniprot.org/uniprot/P03924", "type": "external" } ], "mass": 19078.0, "length": 175, "protein_name": "NADH-ubiquinone oxidoreductase chain 6", "gene_name": "MT-ND6", "organism": "Bovine", "refseq_name": "NADH dehydrogenase subunit 6", "refseq_ac": [ { "id": "YP_209216", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209216", "type": "external" } ], "gene_names_uniprotkb": "MT-ND6; MTND6; NADH6; ND6", "gene_names_refseq": "ND6", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 6; 7.1.1.2; NADH dehydrogenase subunit 6", "protein_names_refseq": "NADH dehydrogenase subunit 6", "tax_id": 9913, "disease": "", "pathway": " (bta:3283888); (R-BTA-5419276); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "25209663;7120390", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P03924-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04038-1", "uniprot_id": [ { "id": "COX6C_BOVIN", "url": "https://www.uniprot.org/uniprot/P04038", "type": "external" } ], "mass": 8610.0, "length": 74, "protein_name": "Cytochrome c oxidase subunit 6C", "gene_name": "COX6C", "organism": "Bovine", "refseq_name": "cytochrome c oxidase subunit 6C", "refseq_ac": [ { "id": "NP_001231040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231040", "type": "external" } ], "gene_names_uniprotkb": "COX6C", "gene_names_refseq": "COX6C", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6C; Cytochrome c oxidase polypeptide VIc; Cytochrome c oxidase subunit STA", "protein_names_refseq": "cytochrome c oxidase subunit 6C", "tax_id": 9913, "disease": "", "pathway": " (bta:614700); (R-BTA-5628897); (R-BTA-611105); (R-BTA-9707564); (R-BTA-9864848)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10089392;10771420;20385840;26698328;27605664;2844245;2988583;31533957;8638158", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JNM4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P04038-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04258-1", "uniprot_id": [ { "id": "CO3A1_BOVIN", "url": "https://www.uniprot.org/uniprot/P04258", "type": "external" } ], "mass": 93651.0, "length": 1049, "protein_name": "Collagen alpha-1(III) chain", "gene_name": "COL3A1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COL3A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(III) chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "488906;488907;488908;488909;488910;488911", "class_list": "", "function": "Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0021987 cerebral cortex development;GO:0030199 collagen fibril organization;GO:0035025 positive regulation of Rho protein signal transduction;GO:2001223 negative regulation of neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04258-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04972-1", "uniprot_id": [ { "id": "CNRG_BOVIN", "url": "https://www.uniprot.org/uniprot/P04972", "type": "external" } ], "mass": 9669.0, "length": 87, "protein_name": "Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "gene_name": "PDE6G", "organism": "Bovine", "refseq_name": "retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "refseq_ac": [ { "id": "NP_776846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776846", "type": "external" } ], "gene_names_uniprotkb": "PDE6G; PDEG", "gene_names_refseq": "PDE6G", "protein_names_uniprotkb": "Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Rod GMP-PDE gamma", "protein_names_refseq": "GMP-PDE gamma; phosphodiesterase 6G, cGMP-specific, rod, gamma; phosphodiesterase, cyclic GMP (rod receptor), gamma polypeptide; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "tax_id": 9913, "disease": "", "pathway": " (bta:281977); (R-BTA-2485179); (R-BTA-2514859); (R-BTA-4086398)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "11234020;11754897;12372317;20600113;25809480;3011376;3015681;30962282;31394113;31690623;33007200;38159849", "class_list": "", "function": "A structural basis for interpreting how mutations in rod PDE6 subunits can lead to retinal diseases, is discussed., [RefSeq, PubMed]; Analysis of the Rod PDE6 holoenzyme (subunit composition, alphabetagammagamma) reveals the mechanism of visual excitation, [RefSeq, PubMed]; Inhibitory gamma subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PubMed:33007200, PubMed:38159849). Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification (PubMed:33007200, PubMed:38159849)., [UniProtKB, PubMed, PubMed]; Physiological differences between rod and cone photoreceptor light responsiveness can be partially ascribed to ancient, highly conserved amino acid differences in the N-terminal regions of Pgamma isoforms, demonstrating for the first time a functional role for this region of Pgamma in the differential activation of rod and cone PDE6 by transducin., [RefSeq, PubMed]; Structural analysis of cGMP phosphodiesterase 6 alpha, beta and gamma interactions, [RefSeq, PubMed]; The 3D structure of the PDE6alphabetagamma complex was determined up to 18 A resolution from single-particle projections and was interpreted by model building to identify the probable location of isoprenylation, PDE6gamma subunits, and catalytic site, [RefSeq, PubMed]; The approximately 11 A map revealed previously unseen features of PDE6, and each domain was readily fit with high resolution structures. Erratum:[J Biol Chem. 2015 Jul 10;290(28):17131-2. doi: 10.1074/jbc.A115.647636. PMID: 26163476], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004857 enzyme inhibitor activity;GO:0008270 zinc ion binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "GO:0097381 photoreceptor disc membrane;GO:0001750 photoreceptor outer segment;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P04972-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05631-1", "uniprot_id": [ { "id": "ATPG_BOVIN", "url": "https://www.uniprot.org/uniprot/P05631", "type": "external" } ], "mass": 33072.0, "length": 298, "protein_name": "ATP synthase F(1) complex subunit gamma, mitochondrial", "gene_name": "ATP5F1C", "organism": "Bovine", "refseq_name": "ATP synthase F(1) complex subunit gamma, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001068604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068604", "type": "external" } ], "gene_names_uniprotkb": "ATP5F1C; ATP5C1; ATP5C", "gene_names_refseq": "ATP5C1; ATP5F1C", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit gamma, mitochondrial; ATP synthase F1 subunit gamma; F-ATPase gamma subunit", "protein_names_refseq": "ATP synthase F(1) complex subunit gamma, mitochondrial precursor; ATP synthase F(1) complex subunit gamma, mitochondrial; ATP synthase subunit gamma, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1; F-ATPase gamma subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:327668); (R-BTA-163210); (R-BTA-8949613); (R-BTA-9837999)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "12505149;12923572;14633978;17570365;17698806;17895376;1827992;20514864;23407638;2526651;25851905;28100784;2864455;41018975;8065448;8391483;8790345;95168;9687365", "class_list": "", "function": "Direction of F1-ATPase subunit gamma rotation, [RefSeq, PubMed]; Molecular dynamic analysis of interaction between the gamma-subunit and a C-terminal fragment of the beta-subunit of F1-ATPase, [RefSeq, PubMed]; Subunit gamma, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit delta, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The beneficial effects of dietary resveratrol may derive in part by preventing mitochondrial ATP synthesis in tumor cells, thereby inducing apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0B4", "ec_number_list": [], "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P05631-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06526-1", "uniprot_id": [ { "id": "TDT_BOVIN", "url": "https://www.uniprot.org/uniprot/P06526", "type": "external" } ], "mass": 58296.0, "length": 509, "protein_name": "DNA nucleotidylexotransferase", "gene_name": "DNTT", "organism": "Bovine", "refseq_name": "DNA nucleotidylexotransferase", "refseq_ac": [ { "id": "NP_803461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803461", "type": "external" } ], "gene_names_uniprotkb": "DNTT; TDT", "gene_names_refseq": "DNTT", "protein_names_uniprotkb": "DNA nucleotidylexotransferase; 2.7.7.31; TDT; Terminal addition enzyme; Terminal deoxynucleotidyltransferase; Terminal transferase", "protein_names_refseq": "DNA nucleotidylexotransferase; TDT; deoxynucleotidyltransferase, terminal; terminal addition enzyme; terminal deoxynucleotidyltransferase; terminal transferase", "tax_id": 9913, "disease": "", "pathway": " (bta:281120)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "22808041;2713339;2910867;3346221;3579900;3755527;6087320", "class_list": "", "function": "Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator (PubMed:3755527). One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells., [UniProtKB, UniProtKB, PubMed]; Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FUF8", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0003912 DNA nucleotidylexotransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006259 DNA metabolic process;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0006304 DNA modification", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P06526-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07552-1", "uniprot_id": [ { "id": "QCR10_BOVIN", "url": "https://www.uniprot.org/uniprot/P07552", "type": "external" } ], "mass": 6520.0, "length": 56, "protein_name": "Cytochrome b-c1 complex subunit 10", "gene_name": "UQCR11", "organism": "Bovine", "refseq_name": "cytochrome b-c1 complex subunit 10", "refseq_ac": [ { "id": "NP_776640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776640", "type": "external" } ], "gene_names_uniprotkb": "UQCR11; UQCR", "gene_names_refseq": "UQCR11; UQCR", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 10; Complex III subunit 10; Complex III subunit XI; Ubiquinol-cytochrome c reductase complex 6.4 kDa protein", "protein_names_refseq": "complex III subunit 10; complex III subunit XI; cytochrome b-c1 complex subunit 10; ubiquinol-cytochrome c reductase (6.4kD) subunit; ubiquinol-cytochrome c reductase complex 6.4 kDa protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281570); (R-BTA-611105); (R-BTA-9865881)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12269811;15312779;16924113;2995132;9161705;9204897;9651245", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1 stability., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A4P1;O18996;Q3T176", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P07552-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C0S4-1", "uniprot_id": [ { "id": "H2AZ_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C0S4", "type": "external" } ], "mass": 13553.0, "length": 128, "protein_name": "Histone H2A.Z", "gene_name": "H2AZ1", "organism": "Bovine", "refseq_name": "histone H2A.Z", "refseq_ac": [ { "id": "NP_777234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777234", "type": "external" } ], "gene_names_uniprotkb": "H2AZ1; H2AZ", "gene_names_refseq": "H2AFZ; H2AZ1", "protein_names_uniprotkb": "Histone H2A.Z; H2A/z", "protein_names_refseq": "H2A histone family, member Z; H2A/z; histone H2A.Z", "tax_id": 9913, "disease": "", "pathway": " (bta:287016); (R-BTA-9970672)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "2713375;3344202;6306766;6832364", "class_list": "", "function": "Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17317;Q32L66", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0C0S4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CH28-1", "uniprot_id": [ { "id": "UBC_BOVIN", "url": "https://www.uniprot.org/uniprot/P0CH28", "type": "external" } ], "mass": 77570.0, "length": 690, "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "organism": "Bovine", "refseq_name": "polyubiquitin-C", "refseq_ac": [ { "id": "NP_001193236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193236", "type": "external" } ], "gene_names_uniprotkb": "UBC", "gene_names_refseq": "UBC", "protein_names_uniprotkb": "Polyubiquitin-C", "protein_names_refseq": "polyubiquitin-C; polyubiquitin", "tax_id": 9913, "disease": "", "pathway": " (bta:444874); (R-BTA-110312); (R-BTA-110314); (R-BTA-110320); (R-BTA-1169091); (R-BTA-1234176); (R-BTA-1253288); (R-BTA-1295596); (R-BTA-1358803); (R-BTA-168638); (R-BTA-174048); (R-BTA-174084); (R-BTA-174113); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-179409); (R-BTA-182971); (R-BTA-187577); (R-BTA-195253); (R-BTA-201681); (R-BTA-202424); (R-BTA-205043); (R-BTA-209543); (R-BTA-209560); (R-BTA-2122948); (R-BTA-2173788); (R-BTA-2173791); (R-BTA-2173795); (R-BTA-2173796); (R-BTA-2467813); (R-BTA-2559582); (R-BTA-2672351); (R-BTA-2871837); (R-BTA-3134975); (R-BTA-349425); (R-BTA-3769402); (R-BTA-382556); (R-BTA-445989); (R-BTA-450302); (R-BTA-450321); (R-BTA-450408); (R-BTA-4608870); (R-BTA-4641257); (R-BTA-4641258); (R-BTA-4641263); (R-BTA-5205685); (R-BTA-532668); (R-BTA-5357905); (R-BTA-5357956); (R-BTA-5358346); (R-BTA-5607761); (R-BTA-5607764); (R-BTA-5610780); (R-BTA-5610785); (R-BTA-5632684); (R-BTA-5654726); (R-BTA-5654727); (R-BTA-5654732); (R-BTA-5654733); (R-BTA-5655862); (R-BTA-5656121); (R-BTA-5656169); (R-BTA-5668541); (R-BTA-5675221); (R-BTA-5675482); (R-BTA-5676590); (R-BTA-5684264); (R-BTA-5685942); (R-BTA-5687128); (R-BTA-5689603); (R-BTA-5689877); (R-BTA-5689880); (R-BTA-5689896); (R-BTA-5689901); (R-BTA-5693537); (R-BTA-5693565); (R-BTA-5693607); (R-BTA-5696394); (R-BTA-5696395); (R-BTA-5696397); (R-BTA-5696400); (R-BTA-6781823); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-6783310); (R-BTA-6804756); (R-BTA-6804757); (R-BTA-6804760); (R-BTA-6807004); (R-BTA-68867); (R-BTA-68949); (R-BTA-69017); (R-BTA-69231); (R-BTA-69481); (R-BTA-69601); (R-BTA-75815); (R-BTA-8849469); (R-BTA-8852276); (R-BTA-8854050); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-8863795); (R-BTA-8866427); (R-BTA-8866652); (R-BTA-8866654); (R-BTA-8939236); (R-BTA-8939902); (R-BTA-8941858); (R-BTA-8948747); (R-BTA-8948751); (R-BTA-8951664); (R-BTA-901032); (R-BTA-9010553); (R-BTA-9020702); (R-BTA-9033241); (R-BTA-909733); (R-BTA-912631); (R-BTA-917729); (R-BTA-917937); (R-BTA-936440); (R-BTA-936964); (R-BTA-937039); (R-BTA-937041); (R-BTA-937042); (R-BTA-937072); (R-BTA-9645460); (R-BTA-9646399); (R-BTA-9648002); (R-BTA-9664873); (R-BTA-9705462); (R-BTA-9706369); (R-BTA-9708530); (R-BTA-975144); (R-BTA-975163); (R-BTA-9755511); (R-BTA-9758274); (R-BTA-9762114); (R-BTA-9766229); (R-BTA-9770562); (R-BTA-9824878); (R-BTA-983168); (R-BTA-9861718); (R-BTA-9929356); (R-BTA-9929491); (R-BTA-9931269); (R-BTA-9931295); (R-BTA-9932298); (R-BTA-9954709); (R-BTA-9954716); (R-BTA-9958810)", "pathway_count": 151, "publication_count": 5, "publication_id_list": "1170880;1322903;1333954;1846490;6254502", "class_list": "", "function": "Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (By similarity). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97577;P02248;P02249;P02250;P0CG52;P62990;P80169;Q01235;Q24K23;Q28169;Q28170;Q29120;Q3T0V5;Q3ZCE3;Q862C1;Q862F4;Q862M4;Q862T5;Q862X8;Q91887;Q91888", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005741 mitochondrial outer membrane;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0019941 modification-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0CH28-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10123-1", "uniprot_id": [ { "id": "RLBP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P10123", "type": "external" } ], "mass": 36505.0, "length": 317, "protein_name": "Retinaldehyde-binding protein 1", "gene_name": "RLBP1", "organism": "Bovine", "refseq_name": "retinaldehyde-binding protein 1", "refseq_ac": [ { "id": "NP_776876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776876", "type": "external" } ], "gene_names_uniprotkb": "RLBP1; CRALBP", "gene_names_refseq": "CRALBP; RLBP1", "protein_names_uniprotkb": "Retinaldehyde-binding protein 1; Cellular retinaldehyde-binding protein", "protein_names_refseq": "cellular retinaldehyde-binding protein; retinaldehyde-binding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282038); (R-BTA-2187335); (R-BTA-2453902)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "16553463;1715867;3198594;3198595", "class_list": "", "function": "Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'., [UniProtKB]; Terminal peptide binds to eye proteins localized to the apical processes of the retinal pigment epithelium., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17QW7", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0019841 retinol binding;GO:0005502 11-cis retinal binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P10123-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10575-1", "uniprot_id": [ { "id": "GLRX1_BOVIN", "url": "https://www.uniprot.org/uniprot/P10575", "type": "external" } ], "mass": 11783.0, "length": 106, "protein_name": "Glutaredoxin-1", "gene_name": "GLRX", "organism": "Bovine", "refseq_name": "glutaredoxin-1", "refseq_ac": [ { "id": "NP_001032693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032693", "type": "external" } ], "gene_names_uniprotkb": "GLRX; GRX", "gene_names_refseq": "GLRXL; GLRX", "protein_names_uniprotkb": "Glutaredoxin-1; TTase; Thioltransferase", "protein_names_refseq": "TTase; glutaredoxin (thioltransferase); glutaredoxin-1; thioltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:515416)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2930571;30573663;6386471", "class_list": "", "function": "Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32KQ3", "ec_number_list": [], "go_molecular_function": "GO:0015038 glutathione disulfide oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P10575-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10730-1", "uniprot_id": [ { "id": "ANPRC_BOVIN", "url": "https://www.uniprot.org/uniprot/P10730", "type": "external" } ], "mass": 59766.0, "length": 537, "protein_name": "Atrial natriuretic peptide receptor 3", "gene_name": "NPR3", "organism": "Bovine", "refseq_name": "atrial natriuretic peptide receptor 3 precursor", "refseq_ac": [ { "id": "NP_776552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776552", "type": "external" } ], "gene_names_uniprotkb": "NPR3; ANPRC", "gene_names_refseq": "NPR3", "protein_names_uniprotkb": "Atrial natriuretic peptide receptor 3; ANP-C; ANPR-C; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; NPR-C", "protein_names_refseq": "ANP-C; ANPR-C; ANPRC; NPR-C; atrial natriuretic peptide C-type receptor; atrial natriuretic peptide clearance receptor; atrial natriuretic peptide receptor 3 precursor; atrial natriuretic peptide receptor 3; atrial natriuretic peptide receptor type C; atrionatriuretic peptide receptor C; natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); natriuretic peptide receptor C", "tax_id": 9913, "disease": "", "pathway": " (bta:281358)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1645726;2557006;2837487;8132555;8444892", "class_list": "", "function": "Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P20644", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0016941 natriuretic peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0008217 regulation of blood pressure;GO:0035810 positive regulation of urine volume;GO:0001501 skeletal system development;GO:0002158 osteoclast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P10730-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13605-1", "uniprot_id": [ { "id": "FMOD_BOVIN", "url": "https://www.uniprot.org/uniprot/P13605", "type": "external" } ], "mass": 43038.0, "length": 376, "protein_name": "Fibromodulin", "gene_name": "FMOD", "organism": "Bovine", "refseq_name": "fibromodulin precursor", "refseq_ac": [ { "id": "NP_776483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776483", "type": "external" } ], "gene_names_uniprotkb": "FMOD", "gene_names_refseq": "FMOD", "protein_names_uniprotkb": "Fibromodulin; Collagen-binding 59 kDa protein; FM; KSPG fibromodulin; Keratan sulfate proteoglycan fibromodulin", "protein_names_refseq": "FM; KSPG fibromodulin; collagen-binding 59 kDa protein; fibromodulin precursor; keratan sulfate proteoglycan fibromodulin", "tax_id": 9913, "disease": "", "pathway": " (bta:281168); (R-BTA-2022854); (R-BTA-2022857)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "14551184;14660626;16305752;17522997;19700767;21892771;2243109;2531085;27634037;8973659", "class_list": "", "function": "Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity)., [UniProtKB]; Fibromodulin and decorin have similarities and differences that may represent the biochemical basis of redundancy in small leucine-rich proteoglycan function, [RefSeq, PubMed]; MMP-13 treatment of fresh articular cartilage results in cleaved fibromodulin fragments, [RefSeq, PubMed]; Some nine tyrosine residues in the fibromodulin N-terminal domain are O-sulfated, a posttranslational modification often involved in protein interactions. Taken together, this study suggests a novel, regulatory function for tyrosine sulfation in Fibromodulin, which controls the interaction with collagen type I., [RefSeq, PubMed]; There are discrete populations of fibromodulin within articular cartilage, which may have differing impacts upon tissue processes., [RefSeq, PubMed]; Tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A7E3X1;Q3SWX6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P13605-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13789-1", "uniprot_id": [ { "id": "TNNT2_BOVIN", "url": "https://www.uniprot.org/uniprot/P13789", "type": "external" } ], "mass": 33914.0, "length": 285, "protein_name": "Troponin T, cardiac muscle", "gene_name": "TNNT2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TNNT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Troponin T, cardiac muscle; Cardiac muscle troponin T; TnTc; cTnT", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "2584239;3122824;6615417;7748902", "class_list": "", "function": "Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P13790", "ec_number_list": [], "go_molecular_function": "GO:0030172 troponin C binding;GO:0005523 tropomyosin binding;GO:0031013 troponin I binding", "go_cellular_component": "GO:0005861 troponin complex", "go_biological_process": "GO:0060048 cardiac muscle contraction;GO:0045214 sarcomere organization;GO:0006937 regulation of muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P13789-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17599-1", "uniprot_id": [ { "id": "SYN1_BOVIN", "url": "https://www.uniprot.org/uniprot/P17599", "type": "external" } ], "mass": 74518.0, "length": 706, "protein_name": "Synapsin-1", "gene_name": "SYN1", "organism": "Bovine", "refseq_name": "synapsin-1", "refseq_ac": [ { "id": "NP_776616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776616", "type": "external" } ], "gene_names_uniprotkb": "SYN1", "gene_names_refseq": "SYN1", "protein_names_uniprotkb": "Synapsin-1; Synapsin I", "protein_names_refseq": "synapsin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:281510)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12237306;14557263;15265865;15265868;1901592;2108963;24280219;2506642;3118371;9463376", "class_list": "", "function": "Interacts with rab3 protein; this interaction is likely to play a major role in the modulation of neurotransmitter release., [RefSeq, PubMed]; Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (By similarity). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Synapsin acts as a phosphorylation-modulated mediator of feedback regulation of Gz signaling by the synaptic machinery, [RefSeq, PubMed]; Synapsin-Rab3 interaction may participate in the regulation of synaptic vesicle trafficking within the nerve terminals., [RefSeq, PubMed]; These results raise the possibility that Ser(603) on synapsin I is alternatively phosphorylated by p21-activated kinases, not only by CaMKII, in neuronal cells in response to some stimulants., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0050808 synapse organization;GO:0007269 neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P17599-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17690-1", "uniprot_id": [ { "id": "APOH_BOVIN", "url": "https://www.uniprot.org/uniprot/P17690", "type": "external" } ], "mass": 38252.0, "length": 345, "protein_name": "Beta-2-glycoprotein 1", "gene_name": "APOH", "organism": "Bovine", "refseq_name": "beta-2-glycoprotein 1 precursor", "refseq_ac": [ { "id": "NP_776417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776417", "type": "external" } ], "gene_names_uniprotkb": "APOH", "gene_names_refseq": "APOH", "protein_names_uniprotkb": "Beta-2-glycoprotein 1; Apo-H; Apolipoprotein H; B2GPI; Beta(2)GPI; Beta-2-glycoprotein I", "protein_names_refseq": "B2GPI; apo-H; beta(2)GPI; beta-2-glycoprotein 1 precursor; beta-2-glycoprotein 1; beta-2-glycoprotein I", "tax_id": 9913, "disease": "", "pathway": " (bta:281006)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1567819;1751487;19674964;2327984", "class_list": "", "function": "Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q148G1;Q28052", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P17690-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19632-1", "uniprot_id": [ { "id": "PHOS_BOVIN", "url": "https://www.uniprot.org/uniprot/P19632", "type": "external" } ], "mass": 28231.0, "length": 245, "protein_name": "Phosducin", "gene_name": "PDC", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PDC", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosducin; 33 kDa phototransducing protein; PHD; Protein MEKA", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "10866677;2203790;2210381;2394752;2770450;9739091", "class_list": "", "function": "Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20940;Q28160", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007601 visual perception;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P19632-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20821-1", "uniprot_id": [ { "id": "GCSH_BOVIN", "url": "https://www.uniprot.org/uniprot/P20821", "type": "external" } ], "mass": 18791.0, "length": 173, "protein_name": "Glycine cleavage system H protein, mitochondrial", "gene_name": "GCSH", "organism": "Bovine", "refseq_name": "glycine cleavage system H protein, mitochondrial precursor", "refseq_ac": [ { "id": "NP_777269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777269", "type": "external" } ], "gene_names_uniprotkb": "GCSH", "gene_names_refseq": "GCSH", "protein_names_uniprotkb": "Glycine cleavage system H protein, mitochondrial; Lipoic acid-containing protein", "protein_names_refseq": "glycine cleavage system H protein, mitochondrial precursor; glycine cleavage system H protein, mitochondrial; glycine cleavage system protein H (aminomethyl carrier); lipoic acid-containing protein", "tax_id": 9913, "disease": "", "pathway": " (bta:317723); (R-BTA-6783984); (R-BTA-9857492)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "20516622;2211640;2553401;3080335", "class_list": "", "function": "The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST)., [UniProtKB, UniProtKB]; X-ray crystal structure of bovine H-protein, a component of the glycine cleavage system, was determined at 0.88 A resolution., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5G3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005960 glycine cleavage complex", "go_biological_process": "GO:0019464 glycine decarboxylation via glycine cleavage system", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20821-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23206-1", "uniprot_id": [ { "id": "COAA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P23206", "type": "external" } ], "mass": 65546.0, "length": 674, "protein_name": "Collagen alpha-1(X) chain", "gene_name": "COL10A1", "organism": "Bovine", "refseq_name": "collagen alpha-1(X) chain precursor", "refseq_ac": [ { "id": "NP_777059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777059", "type": "external" } ], "gene_names_uniprotkb": "COL10A1", "gene_names_refseq": "COL10A1", "protein_names_uniprotkb": "Collagen alpha-1(X) chain", "protein_names_refseq": "collagen alpha-1(X) chain precursor; collagen alpha-1(X) chain; collagen, type X, alpha 1 (Schmid metaphyseal chondrodysplasia); type X collagen alpha 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282416)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15464363;16905550;1703407", "class_list": "", "function": "TSG is an important modulator of BMP-regulated induced collagen II and X expression and cartilage development and chondrocyte differentiation, [RefSeq, PubMed]; The 4.6 kb promoter is able to drive specific expression of Col10a1 in hypertrophic cartilage., [RefSeq, PubMed]; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P23206-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25285-1", "uniprot_id": [ { "id": "GCST_BOVIN", "url": "https://www.uniprot.org/uniprot/P25285", "type": "external" } ], "mass": 42869.0, "length": 397, "protein_name": "Aminomethyltransferase, mitochondrial", "gene_name": "AMT", "organism": "Bovine", "refseq_name": "aminomethyltransferase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_803451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803451", "type": "external" } ], "gene_names_uniprotkb": "AMT", "gene_names_refseq": "AMT", "protein_names_uniprotkb": "Aminomethyltransferase, mitochondrial; 2.1.2.10; GCVT; Glycine cleavage system T protein", "protein_names_refseq": "GCVT; aminomethyltransferase (glycine cleavage system protein T); aminomethyltransferase, mitochondrial precursor; aminomethyltransferase, mitochondrial; glycine cleavage system T protein", "tax_id": 9913, "disease": "", "pathway": " (bta:280719); (R-BTA-6783984)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "2002038", "class_list": "", "function": "The glycine cleavage system catalyzes the degradation of glycine., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.10", "type": "external" } ], "go_molecular_function": "GO:0008483 transaminase activity;GO:0004047 aminomethyltransferase activity;GO:0031405 lipoic acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005960 glycine cleavage complex", "go_biological_process": "GO:0019464 glycine decarboxylation via glycine cleavage system;GO:0006546 glycine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P25285-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27628-1", "uniprot_id": [ { "id": "TUFT1_BOVIN", "url": "https://www.uniprot.org/uniprot/P27628", "type": "external" } ], "mass": 44343.0, "length": 390, "protein_name": "Tuftelin", "gene_name": "TUFT1", "organism": "Bovine", "refseq_name": "tuftelin", "refseq_ac": [ { "id": "NP_776904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776904", "type": "external" } ], "gene_names_uniprotkb": "TUFT1", "gene_names_refseq": "TUFT1", "protein_names_uniprotkb": "Tuftelin; Enamelin", "protein_names_refseq": "enamelin; tuftelin", "tax_id": 9913, "disease": "", "pathway": " (bta:282104)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1874744;9296268", "class_list": "", "function": "Involved in the structural organization of the epidermis (By similarity). Involved in the mineralization and structural organization of enamel., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97683", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005576 extracellular region;GO:0031674 I band;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0031214 biomineral tissue development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P27628-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33946-1", "uniprot_id": [ { "id": "ERD21_BOVIN", "url": "https://www.uniprot.org/uniprot/P33946", "type": "external" } ], "mass": 24574.0, "length": 212, "protein_name": "ER lumen protein-retaining receptor 1", "gene_name": "KDELR1", "organism": "Bovine", "refseq_name": "ER lumen protein-retaining receptor 1", "refseq_ac": [ { "id": "NP_001069963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069963", "type": "external" } ], "gene_names_uniprotkb": "KDELR1; KDELR", "gene_names_refseq": "KDELR1", "protein_names_uniprotkb": "ER lumen protein-retaining receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1", "protein_names_refseq": "ER lumen protein-retaining receptor 1; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL receptor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:618184); (R-BTA-6807878); (R-BTA-6811434)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8380600", "class_list": "", "function": "Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17QP2", "ec_number_list": [], "go_molecular_function": "GO:0005046 KDEL sequence binding;GO:0046923 ER retention sequence binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006621 protein retention in ER lumen", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P33946-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34942-1", "uniprot_id": [ { "id": "NDUAA_BOVIN", "url": "https://www.uniprot.org/uniprot/P34942", "type": "external" } ], "mass": 39264.0, "length": 343, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "gene_name": "NDUFA10", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor", "refseq_ac": [ { "id": "NP_788828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788828", "type": "external" } ], "gene_names_uniprotkb": "NDUFA10", "gene_names_refseq": "NDUFA10", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; CI-42kD; Complex I-42kD; NADH-ubiquinone oxidoreductase 42 kDa subunit", "protein_names_refseq": "CI-42kD; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; NADH-ubiquinone oxidoreductase 42 kDa subunit; complex I-42kD", "tax_id": 9913, "disease": "", "pathway": " (bta:338060)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10852722;15848193;1832859;18721790;28100784", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]; Site of phosphorylation in NDUFA10 from bovine heart mitochondria by tandem mass spectrometry, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P34942-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35466-1", "uniprot_id": [ { "id": "S10A4_BOVIN", "url": "https://www.uniprot.org/uniprot/P35466", "type": "external" } ], "mass": 11807.0, "length": 101, "protein_name": "Protein S100-A4", "gene_name": "S100A4", "organism": "Bovine", "refseq_name": "protein S100-A4", "refseq_ac": [ { "id": "NP_777020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777020", "type": "external" } ], "gene_names_uniprotkb": "S100A4; CAPL", "gene_names_refseq": "S100A4", "protein_names_uniprotkb": "Protein S100-A4; Metastasin; Placental calcium-binding protein homolog; S100 calcium-binding protein A4", "protein_names_refseq": "metastasin; placental calcium-binding protein homolog; protein S100-A4", "tax_id": 9913, "disease": "", "pathway": " (bta:282343)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8119967;9759666", "class_list": "", "function": "Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (By similarity). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBN9", "ec_number_list": [], "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0046914 transition metal ion binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35466-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35722-1", "uniprot_id": [ { "id": "NEUG_BOVIN", "url": "https://www.uniprot.org/uniprot/P35722", "type": "external" } ], "mass": 7549.0, "length": 78, "protein_name": "Neurogranin", "gene_name": "NRGN", "organism": "Bovine", "refseq_name": "neurogranin", "refseq_ac": [ { "id": "NP_001106784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106784", "type": "external" } ], "gene_names_uniprotkb": "NRGN", "gene_names_refseq": "NRGN", "protein_names_uniprotkb": "Neurogranin; B-50 immunoreactive C-kinase substrate; BICKS; NG; p17", "protein_names_refseq": "B-50 immunoreactive C-kinase substrate; BICKS; NG; neurogranin; p17; protein kinase C substrate, RC3", "tax_id": 9913, "disease": "", "pathway": " (bta:616955)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12689827;1824695;23828821;8454596", "class_list": "", "function": "Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium., [UniProtKB]; Interaction of Ca(2+)-free calmodulin (apoCaM) with the IQ motif corresponding to the calmodulin-binding domain of neurogranin has been studied by nuclear magnetic resonance (NMR) methods, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KI68", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P35722-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42029-1", "uniprot_id": [ { "id": "NDUA8_BOVIN", "url": "https://www.uniprot.org/uniprot/P42029", "type": "external" } ], "mass": 20091.0, "length": 172, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "gene_name": "NDUFA8", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "refseq_ac": [ { "id": "NP_787020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787020", "type": "external" } ], "gene_names_uniprotkb": "NDUFA8", "gene_names_refseq": "NDUFA8", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; CI-19kD; CI-PGIV; Complex I-19kD; Complex I-PGIV; NADH-ubiquinone oxidoreductase 19 kDa subunit", "protein_names_refseq": "CI-19kD; CI-PGIV; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; NADH-ubiquinone oxidoreductase 19 kDa subunit; complex I-19kD; complex I-PGIV", "tax_id": 9913, "disease": "", "pathway": " (bta:327710); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "1830204;18721790", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KJF6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P42029-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46163-1", "uniprot_id": [ { "id": "DEFB5_BOVIN", "url": "https://www.uniprot.org/uniprot/P46163", "type": "external" } ], "mass": 7228.0, "length": 64, "protein_name": "Beta-defensin 5", "gene_name": "DEFB5", "organism": "Bovine", "refseq_name": "beta-defensin 5 precursor", "refseq_ac": [ { "id": "NP_001124233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124233", "type": "external" } ], "gene_names_uniprotkb": "DEFB5; BNBD5", "gene_names_refseq": "BNDB-5; DEFB5", "protein_names_uniprotkb": "Beta-defensin 5; BNBD-5; BNDB-5", "protein_names_refseq": "BNBD-5; beta-defensin 5 precursor; neutrophil beta-defensin 5", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "14715566;21067816;8454635;9453661", "class_list": "", "function": "Has bactericidal activity. Active against E.coli ML35 but not against S.aureus 502A., [UniProtKB, PubMed]; MRNA abundances of TLR9, TLR2, and TLR4 together with those of beta-defensin 5 (BNBD5), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands, [RefSeq, PubMed]; This study aimed to evaluate endometrial mRNA levels of toll-like receptors and beta-defensin 5 in Holstein cows by quantitative real time RT-PCR., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97533", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P46163-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46165-1", "uniprot_id": [ { "id": "DEFB7_BOVIN", "url": "https://www.uniprot.org/uniprot/P46165", "type": "external" } ], "mass": 6964.0, "length": 62, "protein_name": "Beta-defensin 7", "gene_name": "DEFB7", "organism": "Bovine", "refseq_name": "beta-defensin 7 precursor", "refseq_ac": [ { "id": "NP_001095832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095832", "type": "external" } ], "gene_names_uniprotkb": "DEFB7", "gene_names_refseq": "BNBD-9; BNDB-9; BNDB9; DEFB7; DEFB8; DEFB9; bnbd3; bnbd7; bnbd8; bnbd9; defb401; defb404", "protein_names_uniprotkb": "Beta-defensin 7; BNBD-7; BNDB-7", "protein_names_refseq": "BNBD-7; BNBD-8; BNDB-7; BNDB-8; Beta-defensin 9; beta-defensin 401; beta-defensin 404; beta-defensin 7 precursor; beta-defensin 8; bovine neutrophil beta-defensin 3; bovine neutrophil beta-defensin 7; bovine neutrophil beta-defensin 9; defensin beta 8; neutrophil beta-defensin-9 like peptide", "tax_id": 9913, "disease": "", "pathway": " (bta:768320)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26255277;8454635", "class_list": "", "function": "Bovine beta-defensin 7 (DEFB7, BNDB7) gene expression is upregulated by 1,25-dihydroxyvitamin D3 in bovine monocytes and by lipopolysaccharide in bovine neutrophils and mammary epithelial cells., [RefSeq, PubMed]; Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32P80", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P46165-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51177-1", "uniprot_id": [ { "id": "GUC1B_BOVIN", "url": "https://www.uniprot.org/uniprot/P51177", "type": "external" } ], "mass": 23728.0, "length": 204, "protein_name": "Guanylyl cyclase-activating protein 2", "gene_name": "GUCA1B", "organism": "Bovine", "refseq_name": "guanylyl cyclase-activating protein 2", "refseq_ac": [ { "id": "NP_777211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777211", "type": "external" } ], "gene_names_uniprotkb": "GUCA1B; GCAP-2; GCAP2", "gene_names_refseq": "GCAP2; GUCA1B", "protein_names_uniprotkb": "Guanylyl cyclase-activating protein 2; GCAP 2; Guanylate cyclase activator 1B; Retinal guanylyl cyclase activator protein p24", "protein_names_refseq": "GCAP 2; guanylate cyclase activator 1B (retina); guanylyl cyclase-activating protein 2; retinal guanylyl cyclase activator protein p24", "tax_id": 9913, "disease": "", "pathway": " (bta:286851)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10383444;22631048;23815670;24026978;26001899;27104297;29440717;7559656;7665624;9620085;9651312", "class_list": "", "function": "Based on the distance constraints imposed by the cross-links, the study derived a 3D-structural model of the GCAP2 homodimer., [RefSeq, PubMed]; Data suggest that dimerization domain of GUCY2D operates as a calcium-sensitive regulatory module; GUCY2D requires correct conformation of monomer-monomer interface for interaction with guanylate cyclase activating proteins (GCAP1; GCAP2)., [RefSeq, PubMed]; Interaction between N-terminally myristoylated GCAP-2 and a peptide derived from the catalytic domain of full-length ROS-GC 1, [RefSeq, PubMed]; Mapping Calcium-Sensitive Regions in the Neuronal Calcium Sensor GCAP2 by Site-Specific Fluorescence Labeling., [RefSeq, PubMed]; Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (PubMed:7665624). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (PubMed:9651312). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; The C-terminal segment in GCAP2 confers target selectivity, facilitates membrane binding and provides sensitivity of the membrane localization of the protein to phosphorylation by rhodopsin kinase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008048 calcium sensitive guanylate cyclase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001917 photoreceptor inner segment;GO:0120199 cone photoreceptor outer segment", "go_biological_process": "GO:0007601 visual perception;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P51177-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53619-1", "uniprot_id": [ { "id": "COPD_BOVIN", "url": "https://www.uniprot.org/uniprot/P53619", "type": "external" } ], "mass": 57274.0, "length": 511, "protein_name": "Coatomer subunit delta", "gene_name": "ARCN1", "organism": "Bovine", "refseq_name": "coatomer subunit delta", "refseq_ac": [ { "id": "NP_001181942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181942", "type": "external" } ], "gene_names_uniprotkb": "ARCN1; COPD", "gene_names_refseq": "ARCN1", "protein_names_uniprotkb": "Coatomer subunit delta; Archain; Delta-COP; Delta-coat protein", "protein_names_refseq": "coat protein delta-cop; coatomer protein complex, subunit delta; coatomer subunit delta; delta-COP; delta-coat protein", "tax_id": 9913, "disease": "", "pathway": " (bta:533078); (R-BTA-6807878); (R-BTA-6811434)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8858162", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0051645 Golgi localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P53619-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53620-1", "uniprot_id": [ { "id": "COPG1_BOVIN", "url": "https://www.uniprot.org/uniprot/P53620", "type": "external" } ], "mass": 97386.0, "length": 874, "protein_name": "Coatomer subunit gamma-1", "gene_name": "COPG1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COPG1; COPG", "gene_names_refseq": "", "protein_names_uniprotkb": "Coatomer subunit gamma-1; Gamma-1-COP; Gamma-1-coat protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:338055)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1360908;14527408;16940185;1898986;8700856", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2T9Q0", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0009306 protein secretion;GO:0072384 organelle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P53620-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55859-1", "uniprot_id": [ { "id": "PNPH_BOVIN", "url": "https://www.uniprot.org/uniprot/P55859", "type": "external" } ], "mass": 32037.0, "length": 289, "protein_name": "Purine nucleoside phosphorylase", "gene_name": "PNP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PNP; NP", "gene_names_refseq": "", "protein_names_uniprotkb": "Purine nucleoside phosphorylase; 2.4.2.1; Inosine phosphorylase; Inosine-guanosine phosphorylase; PNP", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "16305752;7607309;9020983;9585525", "class_list": "", "function": "Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBH6;Q58DQ2", "ec_number_list": [ { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" } ], "go_molecular_function": "GO:0004731 purine-nucleoside phosphorylase activity;GO:0047975 guanosine phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006166 purine ribonucleoside salvage", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55859-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61157-1", "uniprot_id": [ { "id": "ARP3_BOVIN", "url": "https://www.uniprot.org/uniprot/P61157", "type": "external" } ], "mass": 47371.0, "length": 418, "protein_name": "Actin-related protein 3", "gene_name": "ACTR3", "organism": "Bovine", "refseq_name": "actin-related protein 3", "refseq_ac": [ { "id": "NP_776651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776651", "type": "external" } ], "gene_names_uniprotkb": "ACTR3; ARP3", "gene_names_refseq": "ACTR3", "protein_names_uniprotkb": "Actin-related protein 3; Actin-2; Actin-like protein 3", "protein_names_refseq": "ARP3 (actin-related protein 3, yeast) homolog; ARP3 actin related protein 3 homolog; actin-2; actin-like protein 3; actin-related protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:281597); (R-BTA-2029482); (R-BTA-3928662); (R-BTA-5663213); (R-BTA-8856828)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "11721045;12176354;1530599;15505213;23893131;26323303;26598519", "class_list": "", "function": "ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis., [UniProtKB, UniProtKB]; Crystal structure of Arp2/3 complex, [RefSeq, PubMed]; Interacts with contactin and N-WASp, [RefSeq, PubMed]; The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin., [RefSeq, PubMed]; These results demonstrate an important role for CRMP-1 in Listeria actin comet tail formation and open the possibility that CRMP-1 controls cell motility by modulating Arp2/3 activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJ90;P32391;Q08DS8", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0005885 Arp2/3 protein complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060271 cilium assembly;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0010592 positive regulation of lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P61157-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68301-1", "uniprot_id": [ { "id": "MT2_BOVIN", "url": "https://www.uniprot.org/uniprot/P68301", "type": "external" } ], "mass": 6028.0, "length": 61, "protein_name": "Metallothionein-2", "gene_name": "MT2A", "organism": "Bovine", "refseq_name": "metallothionein-2", "refseq_ac": [ { "id": "NP_001068608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068608", "type": "external" } ], "gene_names_uniprotkb": "MT2A; MT2", "gene_names_refseq": "MT-2; MT-II; MT2A; MT2", "protein_names_uniprotkb": "Metallothionein-2; MT-2; MT-II; Metallothionein-II", "protein_names_refseq": "metallothionein 2 A; metallothionein-2; metallothionein-II", "tax_id": 9913, "disease": "", "pathway": " (bta:404070); (R-BTA-5661231)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "30002300;4019500", "class_list": "", "function": "Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids., [UniProtKB]; These results reveal that melatonin and MT2 are essential regulator of bovine granulosa cells function by modulating reproduction-related genes expression, hormones secretion and other regulators of folliculogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09579;Q546G1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071276 cellular response to cadmium ion;GO:0071280 cellular response to copper ion;GO:0010273 detoxification of copper ion;GO:0006882 intracellular zinc ion homeostasis;GO:0071294 cellular response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P68301-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80195-1", "uniprot_id": [ { "id": "GLCM1_BOVIN", "url": "https://www.uniprot.org/uniprot/P80195", "type": "external" } ], "mass": 17152.0, "length": 153, "protein_name": "Glycosylation-dependent cell adhesion molecule 1", "gene_name": "GLYCAM1", "organism": "Bovine", "refseq_name": "glycosylation-dependent cell adhesion molecule 1 precursor", "refseq_ac": [ { "id": "NP_777253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777253", "type": "external" } ], "gene_names_uniprotkb": "GLYCAM1", "gene_names_refseq": "GLYCAM1; PP3", "protein_names_uniprotkb": "Glycosylation-dependent cell adhesion molecule 1; 28 kDa milk glycoprotein PP3; GlyCAM-1; Lactophorin; PP3; Proteose-peptone component 3", "protein_names_refseq": "28 kDa milk glycoprotein PP3; glyCAM-1; glycosylation-dependant cell adhesion molecule 1; glycosylation-dependent cell adhesion molecule 1 precursor; lactophorin; proteose-peptone component 3", "tax_id": 9913, "disease": "", "pathway": " (bta:282430)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12918977;15978734;22099394;37604312;7607540;7999787;8294608;8320368;9613824", "class_list": "", "function": "Data suggest that PP3 monomers associate through hydrophobic interactions via hydrophobic surface of amphipathic helix; PP3 tetramers may act as reservoirs of PP3 molecules in milk products., [RefSeq, PubMed]; PP3 purified from fat-free milk enhanced IgM production of HB4C5 cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P35451;Q32P62", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P80195-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80425-1", "uniprot_id": [ { "id": "FABPL_BOVIN", "url": "https://www.uniprot.org/uniprot/P80425", "type": "external" } ], "mass": 14227.0, "length": 127, "protein_name": "Fatty acid-binding protein, liver", "gene_name": "FABP1", "organism": "Bovine", "refseq_name": "fatty acid-binding protein, liver", "refseq_ac": [ { "id": "NP_787011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787011", "type": "external" } ], "gene_names_uniprotkb": "FABP1", "gene_names_refseq": "FABP1", "protein_names_uniprotkb": "Fatty acid-binding protein, liver; Fatty acid-binding protein 1; L-FABP; Liver-type fatty acid-binding protein", "protein_names_refseq": "L-FABP; fatty acid binding protein 1, liver; fatty acid-binding protein, liver; liver-type fatty acid-binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:327700); (R-BTA-163560); (R-BTA-189483); (R-BTA-400206); (R-BTA-9707564)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "8344916;8541331", "class_list": "", "function": "Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2M2U0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005504 fatty acid binding;GO:0015485 cholesterol binding;GO:0036042 long-chain fatty acyl-CoA binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0071456 cellular response to hypoxia;GO:0015908 fatty acid transport;GO:0070301 cellular response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P80425-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80724-1", "uniprot_id": [ { "id": "BASP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P80724", "type": "external" } ], "mass": 23011.0, "length": 227, "protein_name": "Brain acid soluble protein 1", "gene_name": "BASP1", "organism": "Bovine", "refseq_name": "brain acid soluble protein 1", "refseq_ac": [ { "id": "NP_777205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777205", "type": "external" } ], "gene_names_uniprotkb": "BASP1; NAP22", "gene_names_refseq": "BASP1; NAP22", "protein_names_uniprotkb": "Brain acid soluble protein 1; 22 kDa neuronal tissue-enriched acidic protein; Neuronal axonal membrane protein NAP-22", "protein_names_refseq": "22 kDa neuronal tissue-enriched acidic protein; brain acid soluble protein 1; neuronal axonal membrane protein NAP-22", "tax_id": 9913, "disease": "", "pathway": " (bta:286842); (R-BTA-9035034)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20109554;21156029;9310187;9749536", "class_list": "", "function": "BASP1 fragment truncated by the short N-terminal myristoylated peptide was unable to form oligomers., [RefSeq, PubMed]; Ion channel activity of brain abundant protein BASP1 in planar lipid bilayer, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O02692;Q08E19", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0030426 growth cone", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0045892 negative regulation of DNA-templated transcription;GO:0097435 supramolecular fiber organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P80724-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82918-1", "uniprot_id": [ { "id": "RT18B_BOVIN", "url": "https://www.uniprot.org/uniprot/P82918", "type": "external" } ], "mass": 29174.0, "length": 258, "protein_name": "Small ribosomal subunit protein mS40", "gene_name": "MRPS18B", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein mS40", "refseq_ac": [ { "id": "NP_001033613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033613", "type": "external" } ], "gene_names_uniprotkb": "MRPS18B", "gene_names_refseq": "MRPS18B", "protein_names_uniprotkb": "Small ribosomal subunit protein mS40; 28S ribosomal protein S18-2, mitochondrial; 28S ribosomal protein S18b, mitochondrial; MRP-S18-2; MRP-S18-b; Mrps18-b; S18mt-b", "protein_names_refseq": "28S ribosomal protein S18-2, mitochondrial; 28S ribosomal protein S18b, mitochondrial; MRP-S18-2; MRP-S18-b; S18mt-b; mrps18-b; small ribosomal subunit protein mS40", "tax_id": 9913, "disease": "", "pathway": " (bta:510824)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11279123;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TBM4", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82918-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84088-1", "uniprot_id": [ { "id": "CPLX2_BOVIN", "url": "https://www.uniprot.org/uniprot/P84088", "type": "external" } ], "mass": 15394.0, "length": 134, "protein_name": "Complexin-2", "gene_name": "CPLX2", "organism": "Bovine", "refseq_name": "complexin-2", "refseq_ac": [ { "id": "NP_776708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776708", "type": "external" } ], "gene_names_uniprotkb": "CPLX2", "gene_names_refseq": "CPLX2", "protein_names_uniprotkb": "Complexin-2; CPX II; Complexin II; Synaphin-1", "protein_names_refseq": "CPX II; complexin II; complexin-2; synaphin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:281711)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11929859;12200427;7654227", "class_list": "", "function": "Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09056;Q13329;Q28184;Q64386", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0043195 terminal bouton;GO:0043204 perikaryon;GO:0031201 SNARE complex", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0031915 positive regulation of synaptic plasticity;GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0016079 synaptic vesicle exocytosis;GO:0043303 mast cell degranulation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P84088-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02365-1", "uniprot_id": [ { "id": "NDUB3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02365", "type": "external" } ], "mass": 11141.0, "length": 98, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3", "gene_name": "NDUFB3", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3", "refseq_ac": [ { "id": "NP_788840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788840", "type": "external" } ], "gene_names_uniprotkb": "NDUFB3", "gene_names_refseq": "CI-B12; NDUFB3", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; CI-B12; Complex I-B12; NADH-ubiquinone oxidoreductase B12 subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; NADH-ubiquinone oxidoreductase B12 subunit; complex I-B12", "tax_id": 9913, "disease": "", "pathway": " (bta:338073); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1518044;15728260;18721790", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KJB0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02365-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02367-1", "uniprot_id": [ { "id": "NDUB6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02367", "type": "external" } ], "mass": 15524.0, "length": 128, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6", "gene_name": "NDUFB6", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6", "refseq_ac": [ { "id": "NP_786981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786981", "type": "external" } ], "gene_names_uniprotkb": "NDUFB6", "gene_names_refseq": "B17; NDUFB6", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; CI-B17; Complex I-B17; NADH-ubiquinone oxidoreductase B17 subunit", "protein_names_refseq": "CI-B17; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; NADH-ubiquinone oxidoreductase B17 subunit; complex I-B17", "tax_id": 9913, "disease": "", "pathway": " (bta:327665); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10852722;1518044;18721790", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T079", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042775 mitochondrial ATP synthesis coupled electron transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02367-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09139-1", "uniprot_id": [ { "id": "FABP7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q09139", "type": "external" } ], "mass": 14956.0, "length": 132, "protein_name": "Fatty acid-binding protein, brain", "gene_name": "FABP7", "organism": "Bovine", "refseq_name": "fatty acid-binding protein, brain", "refseq_ac": [ { "id": "NP_001071630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071630", "type": "external" } ], "gene_names_uniprotkb": "FABP7", "gene_names_refseq": "FABP7", "protein_names_uniprotkb": "Fatty acid-binding protein, brain; B-FABP; Brain-type fatty acid-binding protein; Fatty acid-binding protein 7", "protein_names_refseq": "B-FABP; brain-type fatty acid-binding protein; fatty acid binding protein 7, brain; fatty acid-binding protein, brain", "tax_id": 9913, "disease": "", "pathway": " (bta:777787); (R-BTA-163560)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "2266968;2806261", "class_list": "", "function": "FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Binds oleic and palmitic acids but not palmitoyl CoA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17QG9", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q09139-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMW2-1", "uniprot_id": [ { "id": "T184A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMW2", "type": "external" } ], "mass": 45604.0, "length": 414, "protein_name": "Transmembrane protein 184A", "gene_name": "TMEM184A", "organism": "Bovine", "refseq_name": "transmembrane protein 184A", "refseq_ac": [ { "id": "NP_001039737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039737", "type": "external" } ], "gene_names_uniprotkb": "TMEM184A", "gene_names_refseq": "TMEM184A", "protein_names_uniprotkb": "Transmembrane protein 184A", "protein_names_refseq": "transmembrane protein 184A", "tax_id": 9913, "disease": "", "pathway": " (bta:524484)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26769966", "class_list": "", "function": "Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0030658 transport vesicle membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1RMW2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27968-1", "uniprot_id": [ { "id": "DNJC3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27968", "type": "external" } ], "mass": 57704.0, "length": 504, "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "organism": "Bovine", "refseq_name": "dnaJ homolog subfamily C member 3 precursor", "refseq_ac": [ { "id": "NP_777181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777181", "type": "external" } ], "gene_names_uniprotkb": "DNAJC3; P58IPK", "gene_names_refseq": "DNAJC3", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 3; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 3; dnaJ homolog subfamily C member 3 precursor; dnaJ homolog subfamily C member 3; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; protein kinase inhibitor of 58 kDa; protein kinase inhibitor p58", "tax_id": 9913, "disease": "", "pathway": " (bta:286770)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7511204;8666242", "class_list": "", "function": "Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A (PubMed:7511204). May inhibit EIF2AK3/PERK activity (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN99", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0004860 protein kinase inhibitor activity;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0036494 positive regulation of translation initiation in response to endoplasmic reticulum stress;GO:0070417 cellular response to cold;GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:0006986 response to unfolded protein;GO:0034975 protein folding in endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q27968-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28022-1", "uniprot_id": [ { "id": "MFAP5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28022", "type": "external" } ], "mass": 19080.0, "length": 170, "protein_name": "Microfibrillar-associated protein 5", "gene_name": "MFAP5", "organism": "Bovine", "refseq_name": "microfibrillar-associated protein 5 precursor", "refseq_ac": [ { "id": "NP_776811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776811", "type": "external" } ], "gene_names_uniprotkb": "MFAP5; MAGP2", "gene_names_refseq": "MAGP2; MFAP5", "protein_names_uniprotkb": "Microfibrillar-associated protein 5; MAGP-2; MFAP-5; MP25; Microfibril-associated glycoprotein 2", "protein_names_refseq": "MAGP-2; MFAP-5; MP25; microfibril-associated glycoprotein-2; microfibrillar associated protein 5; microfibrillar-associated protein 5 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281908)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15131124;8557636", "class_list": "", "function": "May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results show MAGP-2 is covalently and periodically located along the fibrillin-containing microfibrils of the developing nuchal ligament, suggesting that it is an integral component of most if not all of the microfibrils in this elastic fiber-rich tissue, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZC93", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001527 microfibril", "go_biological_process": "GO:0048048 embryonic eye morphogenesis;GO:0060216 definitive hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28022-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBV3-1", "uniprot_id": [ { "id": "ETFB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBV3", "type": "external" } ], "mass": 27699.0, "length": 255, "protein_name": "Electron transfer flavoprotein subunit beta", "gene_name": "ETFB", "organism": "Bovine", "refseq_name": "electron transfer flavoprotein subunit beta", "refseq_ac": [ { "id": "NP_001033671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033671", "type": "external" } ], "gene_names_uniprotkb": "ETFB", "gene_names_refseq": "ETFB", "protein_names_uniprotkb": "Electron transfer flavoprotein subunit beta; Beta-ETF", "protein_names_refseq": "beta-ETF; electron transfer flavoprotein beta subunit; electron transfer flavoprotein subunit beta; electron-transfer-flavoprotein, beta polypeptide", "tax_id": 9913, "disease": "", "pathway": " (bta:617210)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25023281", "class_list": "", "function": "Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045251 electron transfer flavoprotein complex", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2TBV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LB5-1", "uniprot_id": [ { "id": "GPRL1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LB5", "type": "external" } ], "mass": 27167.0, "length": 241, "protein_name": "GLIPR1-like protein 1", "gene_name": "GLIPR1L1", "organism": "Bovine", "refseq_name": "GLIPR1-like protein 1 precursor", "refseq_ac": [ { "id": "NP_001069825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069825", "type": "external" } ], "gene_names_uniprotkb": "GLIPR1L1", "gene_names_refseq": "GLIPR1L1", "protein_names_uniprotkb": "GLIPR1-like protein 1", "protein_names_refseq": "GLI pathogenesis related 1 like 1; GLIPR1-like protein 1 precursor; GLIPR1-like protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:615034)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22552861;23785420", "class_list": "", "function": "Required for optimal fertilization at the stage of sperm-oocyte fusion, plays a role in optimizing acrosome function, the translocation of IZUMO1 during the acrosome reaction and the fertilization process (PubMed:22552861). Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation (PubMed:23785420). Also a component of the CD9-positive microvesicules found in the cauda region (PubMed:23785420)., [UniProtKB, PubMed, PubMed]; These results suggest that the N-glycosylation moiety of GliPr1L1 is processed during the transit in the epididymal caput., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0001669 acrosomal vesicle;GO:0098635 protein complex involved in cell-cell adhesion", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q32LB5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PI5-1", "uniprot_id": [ { "id": "2AAA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32PI5", "type": "external" } ], "mass": 65291.0, "length": 589, "protein_name": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "gene_name": "PPP2R1A", "organism": "Bovine", "refseq_name": "serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "refseq_ac": [ { "id": "NP_001032554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032554", "type": "external" } ], "gene_names_uniprotkb": "PPP2R1A", "gene_names_refseq": "PP2Aa; PPP2R1A", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; Medium tumor antigen-associated 61 kDa protein; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha; PP2Aa", "protein_names_refseq": "medium tumor antigen-associated 61 kDa protein; protein phosphatase 2, regulatory subunit A, alpha; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "tax_id": 9913, "disease": "", "pathway": " (bta:535321)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12912990", "class_list": "", "function": "The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (By similarity). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, acts as a scaffolding subunit for PPP2CA, which catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (By similarity). Regulates the recruitment of the SKA complex to kinetochores (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0051754 meiotic sister chromatid cohesion, centromeric;GO:0043029 T cell homeostasis;GO:0035331 negative regulation of hippo signaling;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32PI5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYX9-1", "uniprot_id": [ { "id": "ARPC5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYX9", "type": "external" } ], "mass": 16230.0, "length": 151, "protein_name": "Actin-related protein 2/3 complex subunit 5", "gene_name": "ARPC5", "organism": "Bovine", "refseq_name": "actin-related protein 2/3 complex subunit 5", "refseq_ac": [ { "id": "NP_001030524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030524", "type": "external" } ], "gene_names_uniprotkb": "ARPC5", "gene_names_refseq": "ARPC5", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 5; Arp2/3 complex 16 kDa subunit; p16-ARC", "protein_names_refseq": "actin related protein 2/3 complex, subunit 5, 16kDa; actin-related protein 2/3 complex subunit 5; arp2/3 complex 16 kDa subunit; p16-ARC", "tax_id": 9913, "disease": "", "pathway": " (bta:614345)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11721045;15505213;23893131", "class_list": "", "function": "Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB]; The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030863 cortical cytoskeleton;GO:0035861 site of double-strand break;GO:0005885 Arp2/3 protein complex", "go_biological_process": "GO:0016477 cell migration;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3SYX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85100-1", "uniprot_id": [ { "id": "MYL3_BOVIN", "url": "https://www.uniprot.org/uniprot/P85100", "type": "external" } ], "mass": 21939.0, "length": 199, "protein_name": "Myosin light chain 3", "gene_name": "MYL3", "organism": "Bovine", "refseq_name": "myosin light chain 3", "refseq_ac": [ { "id": "NP_001069969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069969", "type": "external" } ], "gene_names_uniprotkb": "MYL3", "gene_names_refseq": "MLC1SB; MYL3", "protein_names_uniprotkb": "Myosin light chain 3; MLC1SB; Myosin light chain 1, slow-twitch muscle B/ventricular isoform", "protein_names_refseq": "myosin light chain 3; myosin, light chain 3, alkali; ventricular, skeletal, slow", "tax_id": 9913, "disease": "", "pathway": " (bta:618352)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "3979397", "class_list": "", "function": "Regulatory light chain of myosin. Does not bind calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003774 cytoskeletal motor activity;GO:0003785 actin monomer binding", "go_cellular_component": "GO:0031674 I band;GO:0016460 myosin II complex;GO:0031672 A band;GO:0016459 myosin complex", "go_biological_process": "GO:0060048 cardiac muscle contraction;GO:0002026 regulation of the force of heart contraction;GO:0006942 regulation of striated muscle contraction;GO:0055010 ventricular cardiac muscle tissue morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P85100-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82917-1", "uniprot_id": [ { "id": "RT18C_BOVIN", "url": "https://www.uniprot.org/uniprot/P82917", "type": "external" } ], "mass": 16214.0, "length": 143, "protein_name": "Small ribosomal subunit protein bS18m", "gene_name": "MRPS18C", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein bS18m", "refseq_ac": [ { "id": "NP_001039973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039973", "type": "external" } ], "gene_names_uniprotkb": "MRPS18C", "gene_names_refseq": "MRPS18C", "protein_names_uniprotkb": "Small ribosomal subunit protein bS18m; 28S ribosomal protein S18-1, mitochondrial; 28S ribosomal protein S18c, mitochondrial; MRP-S18-1; MRP-S18-c; Mrps18-c; S18mt-c", "protein_names_refseq": "28S ribosomal protein S18-1, mitochondrial; 28S ribosomal protein S18c, mitochondrial; MRP-S18-1; MRP-S18-c; S18mt-c; mrps18-c; small ribosomal subunit protein bS18m", "tax_id": 9913, "disease": "", "pathway": " (bta:613561); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279123;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KI03", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82917-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82925-1", "uniprot_id": [ { "id": "RT31_BOVIN", "url": "https://www.uniprot.org/uniprot/P82925", "type": "external" } ], "mass": 43676.0, "length": 386, "protein_name": "Small ribosomal subunit protein mS31", "gene_name": "MRPS31", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein mS31", "refseq_ac": [ { "id": "NP_001069483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069483", "type": "external" } ], "gene_names_uniprotkb": "MRPS31", "gene_names_refseq": "MRPS31", "protein_names_uniprotkb": "Small ribosomal subunit protein mS31; 28S ribosomal protein S31, mitochondrial; MRP-S31; S31mt", "protein_names_refseq": "28S ribosomal protein S31, mitochondrial; MRP-S31; S31mt; small ribosomal subunit protein mS31", "tax_id": 9913, "disease": "", "pathway": " (bta:534185); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279123;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148G3", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82925-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60984-1", "uniprot_id": [ { "id": "GMFB_BOVIN", "url": "https://www.uniprot.org/uniprot/P60984", "type": "external" } ], "mass": 16713.0, "length": 142, "protein_name": "Glia maturation factor beta", "gene_name": "GMFB", "organism": "Bovine", "refseq_name": "glia maturation factor beta", "refseq_ac": [ { "id": "NP_001094707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094707", "type": "external" } ], "gene_names_uniprotkb": "GMFB", "gene_names_refseq": "GMFB", "protein_names_uniprotkb": "Glia maturation factor beta; GMF-beta", "protein_names_refseq": "GMF-beta; glia maturation factor beta", "tax_id": 9913, "disease": "", "pathway": " (bta:615255)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2196564", "class_list": "", "function": "This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7E313;P17774", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008083 growth factor activity;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0071846 actin filament debranching;GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P60984-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82669-1", "uniprot_id": [ { "id": "RT25_BOVIN", "url": "https://www.uniprot.org/uniprot/P82669", "type": "external" } ], "mass": 20055.0, "length": 173, "protein_name": "Small ribosomal subunit protein mS25", "gene_name": "MRPS25", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein mS25", "refseq_ac": [ { "id": "NP_001069447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069447", "type": "external" } ], "gene_names_uniprotkb": "MRPS25; RPMS25", "gene_names_refseq": "MRPS25; S25mt", "protein_names_uniprotkb": "Small ribosomal subunit protein mS25; 28S ribosomal protein S25, mitochondrial; MRP-S25; S25mt", "protein_names_refseq": "28S ribosomal protein S25, mitochondrial; MRP-S25; mitochondrial 28S ribosomal protein S25; small ribosomal subunit protein mS25", "tax_id": 9913, "disease": "", "pathway": " (bta:533011); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10938081;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32P88", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82669-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14790-1", "uniprot_id": [ { "id": "ATP68_BOVIN", "url": "https://www.uniprot.org/uniprot/P14790", "type": "external" } ], "mass": 6834.0, "length": 60, "protein_name": "ATP synthase F(0) complex subunit j, mitochondrial", "gene_name": "ATP5MJ", "organism": "Bovine", "refseq_name": "ATP synthase F(0) complex subunit j, mitochondrial", "refseq_ac": [ { "id": "NP_001106786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106786", "type": "external" } ], "gene_names_uniprotkb": "ATP5MJ; ATP5MPL; MP68", "gene_names_refseq": "ATP5MJ; ATP5MPL; C21H14orf2; MLQ; MP68", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit j, mitochondrial; 6.8 kDa mitochondrial proteolipid protein; 6.8 kDa mitochondrial proteolipid; MLQ", "protein_names_refseq": "6.8 kDa mitochondrial proteolipid protein; ATP synthase F(0) complex subunit j, mitochondrial; ATP synthase membrane subunit 6.8PL; ATP synthase subunit ATP5MJ, mitochondrial; ATP synthase subunit ATP5MPL, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:767909); (R-BTA-163210); (R-BTA-8949613)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17570365;17575325;2298292;25851905", "class_list": "", "function": "In the mitochondrial membrane, both AGP and MLQ proteins are almost quantitatively bound to ATP synthase.[MLQ], [RefSeq, PubMed]; Subunit j, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain. Minor subunit required to maintain the ATP synthase population in the mitochondria (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCB5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P14790-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82916-1", "uniprot_id": [ { "id": "RT17_BOVIN", "url": "https://www.uniprot.org/uniprot/P82916", "type": "external" } ], "mass": 14474.0, "length": 130, "protein_name": "Small ribosomal subunit protein uS17m", "gene_name": "MRPS17", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein uS17m", "refseq_ac": [ { "id": "NP_001019671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019671", "type": "external" } ], "gene_names_uniprotkb": "MRPS17; RPMS17", "gene_names_refseq": "MRPS17", "protein_names_uniprotkb": "Small ribosomal subunit protein uS17m; 28S ribosomal protein S17, mitochondrial; MRP-S17; S17mt", "protein_names_refseq": "28S ribosomal protein S17, mitochondrial; MRP-S17; S17mt; small ribosomal subunit protein uS17m", "tax_id": 9913, "disease": "", "pathway": " (bta:508143); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279123;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2NKU7;Q56K01", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82916-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97725-1", "uniprot_id": [ { "id": "NDUAC_BOVIN", "url": "https://www.uniprot.org/uniprot/O97725", "type": "external" } ], "mass": 17090.0, "length": 145, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12", "gene_name": "NDUFA12", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12", "refseq_ac": [ { "id": "NP_776731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776731", "type": "external" } ], "gene_names_uniprotkb": "NDUFA12", "gene_names_refseq": "DAP13; NDUFA12", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; CI-B17.2; CIB17.2; Complex I-B17.2; NADH-ubiquinone oxidoreductase subunit B17.2", "protein_names_refseq": "13kDa differentiation-associated protein; CI-B17.2; CIB17.2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; NADH-ubiquinone oxidoreductase subunit B17.2; complex I-B17.2", "tax_id": 9913, "disease": "", "pathway": " (bta:281742)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18721790;28100784;9827566", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T092", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O97725-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O62644-1", "uniprot_id": [ { "id": "LECT2_BOVIN", "url": "https://www.uniprot.org/uniprot/O62644", "type": "external" } ], "mass": 16320.0, "length": 151, "protein_name": "Leukocyte cell-derived chemotaxin-2", "gene_name": "LECT2", "organism": "Bovine", "refseq_name": "leukocyte cell-derived chemotaxin-2 precursor", "refseq_ac": [ { "id": "NP_776805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776805", "type": "external" } ], "gene_names_uniprotkb": "LECT2", "gene_names_refseq": "LECT2", "protein_names_uniprotkb": "Leukocyte cell-derived chemotaxin-2; ChM-II; Chondromodulin II; LECT-2; bChM-II; bLECT2", "protein_names_refseq": "LECT-2; bChM-II; bLECT2; cell-derived chemotaxin 2; chM-II; chondromodulin II; leukocyte cell-derived chemotaxin-2 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281899)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10050029;8798437;9524238", "class_list": "", "function": "Has a neutrophil chemotactic activity (PubMed:9524238). Also a positive regulator of chondrocyte proliferation (PubMed:10050029, PubMed:8798437)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBQ8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol", "go_biological_process": "GO:0006935 chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O62644-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02633-1", "uniprot_id": [ { "id": "S100G_BOVIN", "url": "https://www.uniprot.org/uniprot/P02633", "type": "external" } ], "mass": 8918.0, "length": 79, "protein_name": "Protein S100-G", "gene_name": "S100G", "organism": "Bovine", "refseq_name": "protein S100-G", "refseq_ac": [ { "id": "NP_776682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776682", "type": "external" } ], "gene_names_uniprotkb": "S100G; CALB3; S100D", "gene_names_refseq": "CABP; CALB3; S100D; S100G", "protein_names_uniprotkb": "Protein S100-G; CABP; Calbindin-D9k; S100 calcium-binding protein G; Vitamin D-dependent calcium-binding protein, intestinal", "protein_names_refseq": "calbindin 3, (vitamin D-dependent calcium binding protein); calbindin-D9k; protein S100-G; vitamin D-dependent calcium-binding protein, intestinal", "tax_id": 9913, "disease": "", "pathway": " (bta:281658)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "2067016;2200514;22931437;2350544;25880209;2710141;3722173;7240164;7312031;7666423;9194174;9390401", "class_list": "", "function": "TRPV6 and CaBP-9k are expressed during pregnancy in the bovine uterine endometrium and placentomes, suggesting a functional role for these proteins in Ca2+ metabolism during pregnancy. Publication Status: Online-Only, [RefSeq, PubMed]; The study explores ion-binding under native conditions, and demonstrates the ability to detect the chelation of a single calcium ion through the change that ion binding imparts on the effective charge of calbindin D9k., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17Q94", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0005499 vitamin D binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P02633-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C2B6-1", "uniprot_id": [ { "id": "RM51_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C2B6", "type": "external" } ], "mass": 15162.0, "length": 128, "protein_name": "Large ribosomal subunit protein mL51", "gene_name": "MRPL51", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein mL51 precursor", "refseq_ac": [ { "id": "NP_001094558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094558", "type": "external" } ], "gene_names_uniprotkb": "MRPL51", "gene_names_refseq": "L51mt; MRP-L51; MRPL51", "protein_names_uniprotkb": "Large ribosomal subunit protein mL51; 39S ribosomal protein L51, mitochondrial; L51mt; MRP-L51", "protein_names_refseq": "39S ribosomal protein L51, mitochondrial; large ribosomal subunit protein mL51 precursor; large ribosomal subunit protein mL51", "tax_id": 9913, "disease": "", "pathway": " (bta:513622); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11402041;11551941;20601428", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7MB58", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C2B6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DPE2-1", "uniprot_id": [ { "id": "EFCE2_BOVIN", "url": "https://www.uniprot.org/uniprot/P0DPE2", "type": "external" } ], "mass": 99637.0, "length": 883, "protein_name": "EEF1AKMT4-ECE2 readthrough transcript protein", "gene_name": "ECE2; EEF1AKMT4-ECE2; EEF1AKMT4", "organism": "Bovine", "refseq_name": "endothelin-converting enzyme 2 isoform 2a-1", "refseq_ac": [ { "id": "NP_776471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776471", "type": "external" } ], "gene_names_uniprotkb": "ECE2; EEF1AKMT4-ECE2; EEF1AKMT4", "gene_names_refseq": "ECE2; EEF1AKMT4-ECE2; EEF1AKMT4", "protein_names_uniprotkb": "EEF1AKMT4-ECE2 readthrough transcript protein; 3.4.24.71", "protein_names_refseq": "EEF1AKMT4-ECE2 readthrough transcript protein; endothelin-converting enzyme 2 isoform 2a-1", "tax_id": 9913, "disease": "", "pathway": " (bta:281134); (R-BTA-375276)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12054617;19393038;25370848;7797512", "class_list": "", "function": "Converts big endothelin-1 to endothelin-1 (PubMed:7797512). May also have methyltransferase activity (Probable)., [UniProtKB, PubMed]; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides (By similarity). May play a role in amyloid-beta processing (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2, EDN3) and EDN-converting enzymes (ECE1, ECE2) are expressed in epithelial cells; EDN receptors (EDNRA, EDNRB) are present in smooth-muscle. Expression of EDN1, EDN2, and ECE2 is highest on day of ovulation. EDN/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows., [RefSeq, PubMed]; Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2)., [UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A5PJH8;G8JKW4;Q10711;Q547G8;Q865C4", "ec_number_list": [ { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.4.24.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.71", "type": "external" } ], "go_molecular_function": "GO:0008168 methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity;GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0030658 transport vesicle membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0032259 methylation;GO:0007507 heart development;GO:0016485 protein processing;GO:0016486 peptide hormone processing;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0DPE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21752-1", "uniprot_id": [ { "id": "TYB10_BOVIN", "url": "https://www.uniprot.org/uniprot/P21752", "type": "external" } ], "mass": 4805.0, "length": 42, "protein_name": "Thymosin beta-10", "gene_name": "TMSB10", "organism": "Bovine", "refseq_name": "thymosin beta-10", "refseq_ac": [ { "id": "NP_777048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777048", "type": "external" } ], "gene_names_uniprotkb": "TMSB10", "gene_names_refseq": "TMSB10", "protein_names_uniprotkb": "Thymosin beta-10; Thymosin beta-9", "protein_names_refseq": "thymosin beta-10; thymosin beta-9", "tax_id": 9913, "disease": "", "pathway": " (bta:282385)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20883646;3818171;6952223;9108730", "class_list": "", "function": "Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity)., [UniProtKB]; TMSB4 and/or TMSB10 ovarian expression patterns suggest that these two thymosins may be involved in cumulus modifications during maturation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9GMC3", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P21752-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25417-1", "uniprot_id": [ { "id": "CYTB_BOVIN", "url": "https://www.uniprot.org/uniprot/P25417", "type": "external" } ], "mass": 11140.0, "length": 98, "protein_name": "Cystatin-B", "gene_name": "CSTB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CSTB; CST6", "gene_names_refseq": "", "protein_names_uniprotkb": "Cystatin-B; Stefin-B", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:512805)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1515072;1544453", "class_list": "", "function": "This is an intracellular thiol proteinase inhibitor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32PC6", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P25417-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30274-1", "uniprot_id": [ { "id": "CCNA2_BOVIN", "url": "https://www.uniprot.org/uniprot/P30274", "type": "external" } ], "mass": 48262.0, "length": 430, "protein_name": "Cyclin-A2", "gene_name": "CCNA2", "organism": "Bovine", "refseq_name": "cyclin-A2", "refseq_ac": [ { "id": "NP_001068591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068591", "type": "external" } ], "gene_names_uniprotkb": "CCNA2", "gene_names_refseq": "CCNA2; CCNA", "protein_names_uniprotkb": "Cyclin-A2; Cyclin-A", "protein_names_refseq": "cyclin-A2; cyclin-A", "tax_id": 9913, "disease": "", "pathway": " (bta:281667)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1333843;15615710;15736128;8591034", "class_list": "", "function": "B-Myb represses SMC elastin gene expression and cyclin A plays a role in the developmental regulation of elastin gene expression in the aorta, [RefSeq, PubMed]; Essential for the control of the cell cycle at G1/S and G2/M transition (By similarity). Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle (By similarity)., [UniProtKB, UniProtKB]; Inconstant elongation of the poly(A) tail was observed for cyclin A2 transcripts after maturation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17QS7", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0000082 G1/S transition of mitotic cell cycle;GO:0006275 regulation of DNA replication;GO:0044843 cell cycle G1/S phase transition", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P30274-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38584-1", "uniprot_id": [ { "id": "TTL_BOVIN", "url": "https://www.uniprot.org/uniprot/P38584", "type": "external" } ], "mass": 43270.0, "length": 377, "protein_name": "Tubulin--tyrosine ligase", "gene_name": "TTL", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TTL", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubulin--tyrosine ligase; 6.3.2.25; TTL", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8093886", "class_list": "", "function": "Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.25", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0004835 tubulin-tyrosine ligase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005876 spindle microtubule", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P38584-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46164-1", "uniprot_id": [ { "id": "DEFB6_BOVIN", "url": "https://www.uniprot.org/uniprot/P46164", "type": "external" } ], "mass": 4839.0, "length": 42, "protein_name": "Beta-defensin 6", "gene_name": "DEFB6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DEFB6", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-defensin 6; BNBD-6; BNDB-6", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8454635", "class_list": "", "function": "Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P46164-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82649-1", "uniprot_id": [ { "id": "RT22_BOVIN", "url": "https://www.uniprot.org/uniprot/P82649", "type": "external" } ], "mass": 40665.0, "length": 359, "protein_name": "Small ribosomal subunit protein mS22", "gene_name": "MRPS22", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein mS22", "refseq_ac": [ { "id": "NP_001039784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039784", "type": "external" } ], "gene_names_uniprotkb": "MRPS22", "gene_names_refseq": "MRPS22", "protein_names_uniprotkb": "Small ribosomal subunit protein mS22; 28S ribosomal protein S22, mitochondrial; MRP-S22; S22mt", "protein_names_refseq": "28S ribosomal protein S22, mitochondrial; MRP-S22; S22mt; small ribosomal subunit protein mS22", "tax_id": 9913, "disease": "", "pathway": " (bta:532044)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10938081;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2NL06", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82649-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82911-1", "uniprot_id": [ { "id": "RT11_BOVIN", "url": "https://www.uniprot.org/uniprot/P82911", "type": "external" } ], "mass": 20838.0, "length": 197, "protein_name": "Small ribosomal subunit protein uS11m", "gene_name": "MRPS11", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein uS11m", "refseq_ac": [ { "id": "NP_001030250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030250", "type": "external" } ], "gene_names_uniprotkb": "MRPS11", "gene_names_refseq": "MRPS11", "protein_names_uniprotkb": "Small ribosomal subunit protein uS11m; 28S ribosomal protein S11, mitochondrial; MRP-S11; S11mt", "protein_names_refseq": "28S ribosomal protein S11, mitochondrial; MRP-S11; S11mt; small ribosomal subunit protein uS11m", "tax_id": 9913, "disease": "", "pathway": " (bta:509816)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11279123;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0Q7", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0043043 peptide biosynthetic process;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82911-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82913-1", "uniprot_id": [ { "id": "RT15_BOVIN", "url": "https://www.uniprot.org/uniprot/P82913", "type": "external" } ], "mass": 29190.0, "length": 256, "protein_name": "Small ribosomal subunit protein uS15m", "gene_name": "MRPS15", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MRPS15; RPMS15", "gene_names_refseq": "", "protein_names_uniprotkb": "Small ribosomal subunit protein uS15m; 28S ribosomal protein S15, mitochondrial; MRP-S15; S15mt", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "11279123;11402041;19393038;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1BBB4", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P82913-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82919-1", "uniprot_id": [ { "id": "RT18A_BOVIN", "url": "https://www.uniprot.org/uniprot/P82919", "type": "external" } ], "mass": 22281.0, "length": 196, "protein_name": "Large ribosomal subunit protein mL66", "gene_name": "MRPS18A", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein mL66 precursor", "refseq_ac": [ { "id": "NP_001094699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094699", "type": "external" } ], "gene_names_uniprotkb": "MRPS18A", "gene_names_refseq": "MRP-S18-3; MRPS18A", "protein_names_uniprotkb": "Large ribosomal subunit protein mL66; 28S ribosomal protein S18-3, mitochondrial; 28S ribosomal protein S18a, mitochondrial; MRP-S18-3; MRP-S18-a; Mrps18a; S18mt-a", "protein_names_refseq": "28S ribosomal protein S18-3, mitochondrial; 28S ribosomal protein S18a, mitochondrial; MRP-S18-a; S18mt-a; large ribosomal subunit protein mL66 precursor; large ribosomal subunit protein mL66", "tax_id": 9913, "disease": "", "pathway": " (bta:614102)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11279123;11402041;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QLH4", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P82919-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82920-1", "uniprot_id": [ { "id": "RT21_BOVIN", "url": "https://www.uniprot.org/uniprot/P82920", "type": "external" } ], "mass": 10676.0, "length": 87, "protein_name": "Small ribosomal subunit protein bS21m", "gene_name": "MRPS21", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein bS21m", "refseq_ac": [ { "id": "NP_001106778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106778", "type": "external" } ], "gene_names_uniprotkb": "MRPS21; RPMS21", "gene_names_refseq": "MRPS21", "protein_names_uniprotkb": "Small ribosomal subunit protein bS21m; 28S ribosomal protein S21, mitochondrial; MRP-S21; S21mt", "protein_names_refseq": "28S ribosomal protein S21, mitochondrial; MRP-S21; S21mt; small ribosomal subunit protein bS21m", "tax_id": 9913, "disease": "", "pathway": " (bta:614343); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279123;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2HJ36", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82920-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82926-1", "uniprot_id": [ { "id": "RT33_BOVIN", "url": "https://www.uniprot.org/uniprot/P82926", "type": "external" } ], "mass": 12453.0, "length": 106, "protein_name": "Small ribosomal subunit protein mS33", "gene_name": "MRPS33", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein mS33", "refseq_ac": [ { "id": "NP_001032694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032694", "type": "external" } ], "gene_names_uniprotkb": "MRPS33", "gene_names_refseq": "MRP-S33; MRPS33; S33mt", "protein_names_uniprotkb": "Small ribosomal subunit protein mS33; 28S ribosomal protein S33, mitochondrial; MRP-S33; S33mt", "protein_names_refseq": "28S ribosomal protein S33, mitochondrial; ganglioside-induced differentiation-associated-protein 3; mitochondrial 28S ribosomal protein S33; small ribosomal subunit protein mS33", "tax_id": 9913, "disease": "", "pathway": " (bta:523435); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279123;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32LL3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82926-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82928-1", "uniprot_id": [ { "id": "RT28_BOVIN", "url": "https://www.uniprot.org/uniprot/P82928", "type": "external" } ], "mass": 21041.0, "length": 189, "protein_name": "Small ribosomal subunit protein bS1m", "gene_name": "MRPS28", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein bS1m", "refseq_ac": [ { "id": "NP_001039866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039866", "type": "external" } ], "gene_names_uniprotkb": "MRPS28", "gene_names_refseq": "MRPS28", "protein_names_uniprotkb": "Small ribosomal subunit protein bS1m; 28S ribosomal protein S28, mitochondrial; MRP-S28; S28mt", "protein_names_refseq": "28S ribosomal protein S28, mitochondrial; MRP-S28; S28mt; small ribosomal subunit protein bS1m", "tax_id": 9913, "disease": "", "pathway": " (bta:535290); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10751423;10938081;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KI96", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P82928-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC21-1", "uniprot_id": [ { "id": "RM15_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC21", "type": "external" } ], "mass": 33674.0, "length": 297, "protein_name": "Large ribosomal subunit protein uL15m", "gene_name": "MRPL15", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein uL15m precursor", "refseq_ac": [ { "id": "NP_001068913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068913", "type": "external" } ], "gene_names_uniprotkb": "MRPL15", "gene_names_refseq": "MRPL15", "protein_names_uniprotkb": "Large ribosomal subunit protein uL15m; 39S ribosomal protein L15, mitochondrial; L15mt; MRP-L15", "protein_names_refseq": "39S ribosomal protein L15, mitochondrial; L15mt; MRP-L15; large ribosomal subunit protein uL15m precursor; large ribosomal subunit protein uL15m", "tax_id": 9913, "disease": "", "pathway": " (bta:510347); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10593885;11279069", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VC21-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCM5-1", "uniprot_id": [ { "id": "ITIH1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCM5", "type": "external" } ], "mass": 101237.0, "length": 906, "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H1", "gene_name": "ITIH1", "organism": "Bovine", "refseq_name": "inter-alpha-trypsin inhibitor heavy chain H1 precursor", "refseq_ac": [ { "id": "NP_001068821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068821", "type": "external" } ], "gene_names_uniprotkb": "ITIH1", "gene_names_refseq": "ITIH1", "protein_names_uniprotkb": "Inter-alpha-trypsin inhibitor heavy chain H1; ITI heavy chain H1; ITI-HC1; Inter-alpha-inhibitor heavy chain 1", "protein_names_refseq": "ITI heavy chain H1; ITI-HC1; inter-alpha (globulin) inhibitor H1; inter-alpha-inhibitor heavy chain 1; inter-alpha-trypsin inhibitor heavy chain H1 precursor; inter-alpha-trypsin inhibitor heavy chain H1", "tax_id": 9913, "disease": "", "pathway": " (bta:508356)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19674964", "class_list": "", "function": "May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 1, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006953 acute-phase response;GO:0030212 hyaluronan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0VCM5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0100000010011.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26285-1", "uniprot_id": [ { "id": "F262_BOVIN", "url": "https://www.uniprot.org/uniprot/P26285", "type": "external" } ], "mass": 60811.0, "length": 531, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2", "gene_name": "PFKFB2", "organism": "Bovine", "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2", "refseq_ac": [ { "id": "NP_777237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777237", "type": "external" } ], "gene_names_uniprotkb": "PFKFB2", "gene_names_refseq": "PFKFB2", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme; PFK/FBPase 2", "protein_names_refseq": "6-phosphofructo-2-kinase /fructose-2,6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme; 6PF-2-K/Fru-2,6-P2ase 2; PFK-2/FBPase-2; PFK/FBPase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:287019); (R-BTA-9634600)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "20687898;2164212;2539378;27802586;2846551;8179334", "class_list": "", "function": "Crystal structure of human and cattle heart PFKFB2 and the inhibitory influence of citrate on substrate binding has been described., [RefSeq, PubMed]; SGK3 is not required for insulin-induced PFK-2 activation and that this effect is likely mediated by PKBalpha., [RefSeq, PubMed]; Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.105", "type": "external" }, { "id": "3.1.3.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.46", "type": "external" } ], "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0003873 6-phosphofructo-2-kinase activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006000 fructose metabolic process;GO:0006096 glycolytic process;GO:0006003 fructose 2,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P26285-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62871-1", "uniprot_id": [ { "id": "GBB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P62871", "type": "external" } ], "mass": 37377.0, "length": 340, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "gene_name": "GNB1", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "refseq_ac": [ { "id": "NP_786971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786971", "type": "external" } ], "gene_names_uniprotkb": "GNB1", "gene_names_refseq": "GNB1; HG2A", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Transducin beta chain 1", "protein_names_refseq": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; guanine nucleotide-binding protein, beta-1 subunit; heterotrimeric guanine nucleotide-binding protein 2A; transducin beta chain 1", "tax_id": 9913, "disease": "", "pathway": " (bta:281201); (R-BTA-1296041); (R-BTA-202040); (R-BTA-2485179); (R-BTA-381676); (R-BTA-381753); (R-BTA-381771); (R-BTA-392170); (R-BTA-392451); (R-BTA-392851); (R-BTA-400042); (R-BTA-4086398); (R-BTA-416476); (R-BTA-416482); (R-BTA-418217); (R-BTA-418555); (R-BTA-418592); (R-BTA-418594); (R-BTA-418597); (R-BTA-420092); (R-BTA-428930); (R-BTA-432040); (R-BTA-456926); (R-BTA-500657); (R-BTA-6814122); (R-BTA-8964315); (R-BTA-8964616); (R-BTA-9009391); (R-BTA-9717207); (R-BTA-9856530); (R-BTA-997272)", "pathway_count": 31, "publication_count": 9, "publication_id_list": "12486123;12764189;2414128;27088923;28655769;3083416;8521505;8552196;9739091", "class_list": "", "function": "Data suggest that a hetero-multimer complex forms between light-activated rhodopsin and light-activated heterotrimeric transducin (T-alpha-1, Gnb1, Gngt1); the stoichiometry is 1:1 rhodopsin:transducin. The complex appears to form on native rod outer segment membranes upon light activation., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The PIP2-induced orientation of the GRK2-Gbeta1gamma2 complex is therefore most likely caused by specific interactions between PIP2 and the GRK2 PH domain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04697;P04901;Q3MHF1", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0045202 synapse;GO:0097381 photoreceptor disc membrane;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0071380 cellular response to prostaglandin E stimulus;GO:0071870 cellular response to catecholamine stimulus;GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P62871-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04116-1", "uniprot_id": [ { "id": "MYPR_BOVIN", "url": "https://www.uniprot.org/uniprot/P04116", "type": "external" } ], "mass": 30015.0, "length": 277, "protein_name": "Myelin proteolipid protein", "gene_name": "PLP1", "organism": "Bovine", "refseq_name": "myelin proteolipid protein", "refseq_ac": [ { "id": "NP_776574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776574", "type": "external" } ], "gene_names_uniprotkb": "PLP1; PLP", "gene_names_refseq": "PLP1; PLP", "protein_names_uniprotkb": "Myelin proteolipid protein; Lipophilin; PLP", "protein_names_refseq": "lipophilin; myelin proteolipid protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281410)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "1281423;1692031;1695508;1700073;1711121;1717653;2450106;2473918;3840591;6195969;6206491;6642431;7540658;9130268;9800346", "class_list": "", "function": "This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2VDT3;Q3ZBU4;Q9TSH8", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043209 myelin sheath", "go_biological_process": "GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression;GO:0022010 central nervous system myelination;GO:0042552 myelination;GO:0048469 cell maturation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P04116-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5I5-1", "uniprot_id": [ { "id": "HOGA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5I5", "type": "external" } ], "mass": 35217.0, "length": 327, "protein_name": "4-hydroxy-2-oxoglutarate aldolase, mitochondrial", "gene_name": "HOGA1", "organism": "Bovine", "refseq_name": "4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001068705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068705", "type": "external" } ], "gene_names_uniprotkb": "HOGA1; DHDPSL", "gene_names_refseq": "C10orf65; DHDPSL; HOGA1; NPL2", "protein_names_uniprotkb": "4-hydroxy-2-oxoglutarate aldolase, mitochondrial; 4.1.3.16; DHDPS-like protein; Dihydrodipicolinate synthase-like; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase", "protein_names_refseq": "4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor; DHDPS-like protein; N-acetylneuraminate pyruvate lyase 2 (putative); dihydrodipicolinate synthase-like, mitochondrial; probable 2-keto-4-hydroxyglutarate aldolase; probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; probable KHG-aldolase", "tax_id": 9913, "disease": "", "pathway": " (bta:506001); (R-BTA-389661)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1587831;16305752;20797690;21998747;25372828", "class_list": "", "function": "Catalyzes the final step in the metabolic pathway of hydroxyproline., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Native HOGA was purified from bovine kidney using a novel microtitration protocol to obtain diffraction-quality crystals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0V7M3", "ec_number_list": [ { "id": "4.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0008700 (R,S)-4-hydroxy-2-oxoglutarate aldolase activity;GO:0106009 (4S)-4-hydroxy-2-oxoglutarate aldolase activity;GO:0016833 oxo-acid-lyase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009436 glyoxylate catabolic process;GO:0044281 small molecule metabolic process;GO:0033609 oxalate metabolic process;GO:0042866 pyruvate biosynthetic process;GO:0019470 trans-4-hydroxy-L-proline catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q0P5I5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28327-1", "uniprot_id": [ { "id": "GRK1_BOVIN", "url": "https://www.uniprot.org/uniprot/P28327", "type": "external" } ], "mass": 62934.0, "length": 561, "protein_name": "Rhodopsin kinase GRK1", "gene_name": "GRK1", "organism": "Bovine", "refseq_name": "rhodopsin kinase GRK1", "refseq_ac": [ { "id": "NP_776598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776598", "type": "external" } ], "gene_names_uniprotkb": "GRK1; RHOK", "gene_names_refseq": "GRK1; RHOK", "protein_names_uniprotkb": "Rhodopsin kinase GRK1; 2.7.11.14; G protein-coupled receptor kinase 1; RK", "protein_names_refseq": "RK; rhodopsin kinase GRK1", "tax_id": 9913, "disease": "", "pathway": " (bta:281457); (R-BTA-2514859)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12686556;14561760;1527025;15355976;1656454;16675451;17020884;1730692;18339619;20966068;21299498;22684056;22846544;24189072;26001899;26584024", "class_list": "", "function": "A novel rhodopsin-kinase-binding site within the C-terminal region of recoverin., [RefSeq, PubMed]; Crystalline dimer interface was disrupted with a L166K mutation and the structure of GRK1-L166K was determined in complex with Mg(2+) . ATP to 2.5 A resolution, [RefSeq, PubMed]; Recoverin and rhodopsin kinase have roles in a Ca2+-dependent feedback loop in membrane rafts from rod outer segments, [RefSeq, PubMed]; Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:12686556, PubMed:16675451, PubMed:21299498). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Similar to transducin activation, rhodopsin phosphorylation by GRK1 and high affinity arrestin-1 binding only requires a rhodopsin monomer, [RefSeq, PubMed]; The C-terminal segment in GCAP2 confers target selectivity, facilitates membrane binding and provides sensitivity of the membrane localization of the protein to phosphorylation by rhodopsin kinase., [RefSeq, PubMed]; The methylation status of GRK1 is affected by nucleotide binding and by the levels of free Ca2 + via recoverin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.14", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0050254 rhodopsin kinase activity;GO:0004703 G protein-coupled receptor kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0097381 photoreceptor disc membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0009966 regulation of signal transduction;GO:0022400 regulation of opsin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P28327-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56722-1", "uniprot_id": [ { "id": "PTPRN_BOVIN", "url": "https://www.uniprot.org/uniprot/P56722", "type": "external" } ], "mass": 105908.0, "length": 979, "protein_name": "Receptor-type tyrosine-protein phosphatase-like N", "gene_name": "PTPRN", "organism": "Bovine", "refseq_name": "receptor-type tyrosine-protein phosphatase-like N precursor", "refseq_ac": [ { "id": "NP_001068599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068599", "type": "external" } ], "gene_names_uniprotkb": "PTPRN", "gene_names_refseq": "PTPRN", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase-like N; ICA512; Islet cell autoantigen 512; R-PTP-N", "protein_names_refseq": "ICA512; R-PTP-N; islet cell autoantigen 512; receptor-type tyrosine-protein phosphatase-like N precursor; receptor-type tyrosine-protein phosphatase-like N", "tax_id": 9913, "disease": "", "pathway": " (bta:286810)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10457160;8641276", "class_list": "", "function": "ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4. Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3. ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis., [UniProtKB, UniProtKB]; ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2., [UniProtKB, UniProtKB, UniProtKB]; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. Seems to lack intrinsic enzyme activity. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q0VD45", "ec_number_list": [], "go_molecular_function": "GO:0030507 spectrin binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030141 secretory granule", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000302 response to reactive oxygen species;GO:0051046 regulation of secretion;GO:0001553 luteinization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P56722-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14769-1", "uniprot_id": [ { "id": "GGTA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P14769", "type": "external" } ], "mass": 43247.0, "length": 368, "protein_name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase", "gene_name": "GGTA1", "organism": "Bovine", "refseq_name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase", "refseq_ac": [ { "id": "NP_803477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803477", "type": "external" } ], "gene_names_uniprotkb": "GGTA1", "gene_names_refseq": "GGTA1", "protein_names_uniprotkb": "N-acetyllactosaminide alpha-1,3-galactosyltransferase; 2.4.1.87; Galactosyltransferase; UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase", "protein_names_refseq": "N-acetyllactosaminide alpha-1,3-galactosyltransferase; UDP-galactose:beta-D-galactosyl-1, 4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase; alpha-galactosyltransferase 1 (glycoprotein); alpha1,3-galactosyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:281780)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11179209;11592969;12011052;23578032;2503516", "class_list": "glycogene;glycosyltransferase", "function": "Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isoglobotrihexosylceramide or isogloboside 3 (iGb3)., [UniProtKB, UniProtKB]; The results suggest that in alpha1,3-GalT the substrate-assisted catalysis would be necessary in both mechanisms, because the nucleophilic strength of Glu317 is reduced by the interactions it makes to ensure proper acceptor binding., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.87", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.87", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016757 glycosyltransferase activity;GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031982 vesicle;GO:0032580 Golgi cisterna membrane;GO:0031985 Golgi cisterna", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 43, "hit_score": 0.6, "record_id": "P14769-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68827-1", "uniprot_id": [ { "id": "NAGPA_BOVIN", "url": "https://www.uniprot.org/uniprot/P68827", "type": "external" } ], "mass": 57223.0, "length": 527, "protein_name": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase", "gene_name": "NAGPA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NAGPA", "gene_names_refseq": "", "protein_names_uniprotkb": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; 3.1.4.45; Mannose 6-phosphate-uncovering enzyme; Phosphodiester alpha-GlcNAcase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "8294420;8294421;9722550", "class_list": "", "function": "Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.45", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.45", "type": "external" } ], "go_molecular_function": "GO:0003944 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0033299 secretion of lysosomal enzymes", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P68827-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27957-1", "uniprot_id": [ { "id": "TPPP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27957", "type": "external" } ], "mass": 23473.0, "length": 218, "protein_name": "Tubulin polymerization-promoting protein", "gene_name": "TPPP", "organism": "Bovine", "refseq_name": "tubulin polymerization-promoting protein", "refseq_ac": [ { "id": "NP_776401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776401", "type": "external" } ], "gene_names_uniprotkb": "TPPP", "gene_names_refseq": "TPPP; p25", "protein_names_uniprotkb": "Tubulin polymerization-promoting protein; 25 kDa brain-specific protein; 3.6.5.-; TPPP; p25-alpha", "protein_names_refseq": "25 kDa brain-specific protein; brain-specific protein p25 alpha; p25-alpha; tubulin polymerization-promoting protein", "tax_id": 9913, "disease": "", "pathway": " (bta:280968)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14623963;17027006;17693641;1909972;7647094", "class_list": "", "function": "Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (By similarity). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (By similarity). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (By similarity). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (By similarity). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:14623963). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (By similarity). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (By similarity). Plays a role in cell proliferation by regulating the G1/S-phase transition (By similarity). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2VDP9;Q9TRW3;Q9TRW4", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005815 microtubule organizing center;GO:0072686 mitotic spindle", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0051301 cell division;GO:0031334 positive regulation of protein-containing complex assembly;GO:0014003 oligodendrocyte development;GO:0032288 myelin assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q27957-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48452-1", "uniprot_id": [ { "id": "PP2BA_BOVIN", "url": "https://www.uniprot.org/uniprot/P48452", "type": "external" } ], "mass": 58672.0, "length": 521, "protein_name": "Protein phosphatase 3 catalytic subunit alpha", "gene_name": "PPP3CA", "organism": "Bovine", "refseq_name": "protein phosphatase 3 catalytic subunit alpha", "refseq_ac": [ { "id": "NP_777212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777212", "type": "external" } ], "gene_names_uniprotkb": "PPP3CA", "gene_names_refseq": "PPP3CA", "protein_names_uniprotkb": "Protein phosphatase 3 catalytic subunit alpha; 3.1.3.16; CAM-PRP catalytic subunit; CNA alpha; Calcineurin A alpha; Calmodulin-dependent calcineurin A subunit alpha isoform; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform", "protein_names_refseq": "CAM-PRP catalytic subunit; CNA alpha; calcineurin A alpha; protein phosphatase 3 catalytic subunit alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:286852); (R-BTA-2025928); (R-BTA-2871809); (R-BTA-4086398); (R-BTA-5607763)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "1328240;15967565;16411749;16705489;1715244;7543369", "class_list": "", "function": "Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:1328240, PubMed:15967565, PubMed:16411749, PubMed:1715244). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (By similarity). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (PubMed:1328240). Dephosphorylates and activates transcription factor NFATC1 (By similarity). Dephosphorylates and inactivates transcription factor ELK1 (By similarity). Dephosphorylates DARPP32 (By similarity). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (By similarity). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (By similarity). Negatively regulates SLC9A1 activity (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The calmodulin binding region from residues 389 to 420 was modeled based on the structure of two other proteins having calmodulin binding domains with the same 1-8-14 structural motif as calcineurin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08DM4;Q309F2", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0046983 protein dimerization activity;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043197 dendritic spine;GO:0042383 sarcolemma;GO:0030018 Z disc", "go_biological_process": "GO:0016311 dephosphorylation;GO:0051592 response to calcium ion;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation;GO:0048741 skeletal muscle fiber development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P48452-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62157-1", "uniprot_id": [ { "id": "CALM_BOVIN", "url": "https://www.uniprot.org/uniprot/P62157", "type": "external" } ], "mass": 16838.0, "length": 149, "protein_name": "Calmodulin", "gene_name": "CALM1; CALM3; CALM", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CALM1; CALM3; CALM; CAM", "gene_names_refseq": "", "protein_names_uniprotkb": "Calmodulin; CaM", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:100297344); (bta:520277); (bta:617095)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "11320306;11457842;12658628;1519061;3058479;3375233;37011209;7356670;7634090;7803388;8022785;8259515;8262263;8341712;9305950;9438860;9716384", "class_list": "", "function": "Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding. Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02593;P70667;P99014;Q08D84;Q2KJE6;Q61379;Q61380", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0005513 detection of calcium ion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P62157-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20004-1", "uniprot_id": [ { "id": "ACON_BOVIN", "url": "https://www.uniprot.org/uniprot/P20004", "type": "external" } ], "mass": 85359.0, "length": 780, "protein_name": "Aconitate hydratase, mitochondrial", "gene_name": "ACO2", "organism": "Bovine", "refseq_name": "aconitate hydratase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776402", "type": "external" } ], "gene_names_uniprotkb": "ACO2", "gene_names_refseq": "ACO2", "protein_names_uniprotkb": "Aconitate hydratase, mitochondrial; 4.2.1.3; Aconitase; Citrate hydro-lyase", "protein_names_refseq": "aconitase 2, mitochondrial; aconitate hydratase, mitochondrial precursor; aconitate hydratase, mitochondrial; citrate hydro-lyase", "tax_id": 9913, "disease": "", "pathway": " (bta:280976); (R-BTA-71403); (R-BTA-9837999); (R-BTA-9854311)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "1547214;2511202;3372519", "class_list": "", "function": "Catalyzes the isomerization of citrate to isocitrate via cis-aconitate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZZ1", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0003994 aconitate hydratase activity;GO:0005506 iron ion binding;GO:0051538 3 iron, 4 sulfur cluster binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0008198 ferrous iron binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006101 citrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P20004-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10096-1", "uniprot_id": [ { "id": "G3P_BOVIN", "url": "https://www.uniprot.org/uniprot/P10096", "type": "external" } ], "mass": 35868.0, "length": 333, "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase", "gene_name": "GAPDH", "organism": "Bovine", "refseq_name": "glyceraldehyde-3-phosphate dehydrogenase", "refseq_ac": [ { "id": "NP_001029206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029206", "type": "external" } ], "gene_names_uniprotkb": "GAPDH; GAPD", "gene_names_refseq": "GAPDH; GAPD", "protein_names_uniprotkb": "Glyceraldehyde-3-phosphate dehydrogenase; 1.2.1.12; 2.6.99.-; GAPDH; Peptidyl-cysteine S-nitrosylase GAPDH", "protein_names_refseq": "glyceraldehyde phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase; peptidyl-cysteine S-nitrosylase GAPDH", "tax_id": 9913, "disease": "", "pathway": " (bta:281181); (R-BTA-70171); (R-BTA-70263)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1201027;12488440;15342727;17027006;17927910;24059522", "class_list": "", "function": "Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis. Also shows nitrosylase activity, thereby playing a role in nuclear functions (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; GAPDH phosphorylates the long intracellular loop of GABA(A) receptor alpha1 subunit at Ser-416 & Thr-337. The neuronal membrane-attached GAPDH is a dual-purpose enzyme, a glycolytic dehydrogenase, & a receptor-associated kinase., [RefSeq, PubMed]; GAPDH with CytOx could be the point of interest as it has already been shown that GAPDH protein damage results in a marked decrease in cellular ATP levels, [RefSeq, PubMed]; Present in, and accounts for, glycolysis and glutamate accumulation into synaptic vesicles, [RefSeq, PubMed]; Results show that expression of GAPD increased during the late fattening stage of of hanwoo steers and it is involved in metabolic pathways such as glycolysis and the TCA cycle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P79130;Q3ZCB1", "ec_number_list": [ { "id": "1.2.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.12", "type": "external" }, { "id": "2.6.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.99.-", "type": "external" } ], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0097718 disordered domain specific binding;GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0051402 neuron apoptotic process;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0050821 protein stabilization;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P10096-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25500-1", "uniprot_id": [ { "id": "PAPOA_BOVIN", "url": "https://www.uniprot.org/uniprot/P25500", "type": "external" } ], "mass": 82441.0, "length": 739, "protein_name": "Poly(A) polymerase alpha", "gene_name": "PAPOLA", "organism": "Bovine", "refseq_name": "poly(A) polymerase alpha", "refseq_ac": [ { "id": "NP_788820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788820", "type": "external" } ], "gene_names_uniprotkb": "PAPOLA; PAP", "gene_names_refseq": "PAPOLA", "protein_names_uniprotkb": "Poly(A) polymerase alpha; 2.7.7.19; PAP-alpha; Polynucleotide adenylyltransferase alpha", "protein_names_refseq": "PAP-alpha; poly (A) polymerase beta (testis specific); poly(A) polymerase alpha; polynucleotide adenylyltransferase alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:338051); (R-BTA-73856); (R-BTA-77595); (R-BTA-9770562)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10944102;15328606;17172643;1756732;1896071;8665867;9463383", "class_list": "", "function": "Polymerase that creates the 3'-poly(A) tail of mRNA's., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 41, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway;GO:0006397 mRNA processing;GO:0031123 RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P25500-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15396-1", "uniprot_id": [ { "id": "ENPP3_BOVIN", "url": "https://www.uniprot.org/uniprot/P15396", "type": "external" } ], "mass": 99523.0, "length": 874, "protein_name": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 3", "gene_name": "ENPP3", "organism": "Bovine", "refseq_name": "ectonucleotide pyrophosphatase/phosphodiesterase family member 3", "refseq_ac": [ { "id": "NP_001069391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069391", "type": "external" } ], "gene_names_uniprotkb": "ENPP3", "gene_names_refseq": "ENPP3", "protein_names_uniprotkb": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; 3.1.4.1; 3.6.1.-; 3.6.1.9; Alkaline phosphodiesterase I; Dinucleoside polyphosphatase; E-NPP 3; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; PD-Ibeta; Phosphodiesterase I beta; Phosphodiesterase I/nucleotide pyrophosphatase 3", "protein_names_refseq": "E-NPP 3; NPPase; PD-Ibeta; alkaline phosphodiesterase I; dinucleoside polyphosphatase; ectonucleotide pyrophosphatase/phosphodiesterase family member 3; nucleotide diphosphatase; phosphodiesterase I beta; phosphodiesterase I/nucleotide pyrophosphatase 3", "tax_id": 9913, "disease": "", "pathway": " (bta:529405)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2989287", "class_list": "", "function": "Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Also hydrolyzes extracellular 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production, and is therefore involved in the regulation of innate immune response (By similarity). 2',3'-cGAMP appears to be further processed to GMP, AMP and inorganic phosphate (By similarity). Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation (By similarity). Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q0II99", "ec_number_list": [ { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.91", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91", "type": "external" }, { "id": "3.1.3.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89", "type": "external" }, { "id": "3.1.3.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99", "type": "external" }, { "id": "3.1.3.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" }, { "id": "3.6.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.76", "type": "external" }, { "id": "3.6.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.17", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.6.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59", "type": "external" }, { "id": "3.6.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.52", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.10", "type": "external" }, { "id": "3.6.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.61", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "2.7.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.77", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.7.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.51", "type": "external" }, { "id": "3.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.2.1", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "3.6.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.60", "type": "external" } ], "go_molecular_function": "GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0036219 GTP diphosphatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0055062 phosphate ion homeostasis;GO:0046034 ATP metabolic process;GO:0009143 nucleoside triphosphate catabolic process;GO:0070667 negative regulation of mast cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P15396-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28204-1", "uniprot_id": [ { "id": "KCMA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28204", "type": "external" } ], "mass": 130063.0, "length": 1166, "protein_name": "Calcium-activated potassium channel subunit alpha-1", "gene_name": "KCNMA1", "organism": "Bovine", "refseq_name": "calcium-activated potassium channel subunit alpha-1", "refseq_ac": [ { "id": "NP_777105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777105", "type": "external" } ], "gene_names_uniprotkb": "KCNMA1; KCNMA", "gene_names_refseq": "KCNMA1", "protein_names_uniprotkb": "Calcium-activated potassium channel subunit alpha-1; BK channel; BKCA alpha; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; Slo homolog; Slo-alpha; Slo1; Slowpoke homolog; bSlo", "protein_names_refseq": "BK channel; BKCA alpha; KCa1.1; bSlo; calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel, subfamily M subunit alpha-1; k(VCA)alpha; maxi K channel; maxiK; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; slo homolog; slo-alpha; slo1; slowpoke homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:282573); (R-BTA-1296052)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11514553;16341213;19473978;8973172", "class_list": "", "function": "Analysis of SLO3 K+ channels shows evolutionary divergence for an RCK1 region of critical function, [RefSeq, PubMed]; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95J89;Q95J90;Q95J91", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0005267 potassium channel activity;GO:0015269 calcium-activated potassium channel activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043195 terminal bouton", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0034465 response to carbon monoxide;GO:0006970 response to osmotic stress;GO:0019228 neuronal action potential;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q28204-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07516-1", "uniprot_id": [ { "id": "PPR1B_BOVIN", "url": "https://www.uniprot.org/uniprot/P07516", "type": "external" } ], "mass": 22614.0, "length": 202, "protein_name": "Protein phosphatase 1 regulatory subunit 1B", "gene_name": "PPP1R1B", "organism": "Bovine", "refseq_name": "protein phosphatase 1 regulatory subunit 1B", "refseq_ac": [ { "id": "NP_777072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777072", "type": "external" } ], "gene_names_uniprotkb": "PPP1R1B", "gene_names_refseq": "PPP1R1B", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 1B; DARPP-32; Dopamine- and cAMP-regulated neuronal phosphoprotein", "protein_names_refseq": "DARPP-32; dopamine and cAMP regulated; dopamine- and cAMP-regulated neuronal phosphoprotein; protein phosphatase 1 regulatory subunit 1B; protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)", "tax_id": 9913, "disease": "", "pathway": " (bta:282459); (R-BTA-180024)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "3339428;3511054;7826384", "class_list": "", "function": "Inhibitor of protein-phosphatase 1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17QN1", "ec_number_list": [], "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0032839 dendrite cytoplasm;GO:1904115 axon cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P07516-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04975-1", "uniprot_id": [ { "id": "CLCB_BOVIN", "url": "https://www.uniprot.org/uniprot/P04975", "type": "external" } ], "mass": 25082.0, "length": 228, "protein_name": "Clathrin light chain B", "gene_name": "CLTB", "organism": "Bovine", "refseq_name": "clathrin light chain B", "refseq_ac": [ { "id": "NP_776702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776702", "type": "external" } ], "gene_names_uniprotkb": "CLTB; CLTLB", "gene_names_refseq": "CLTB; CLTLB", "protein_names_uniprotkb": "Clathrin light chain B; Lcb", "protein_names_refseq": "clathrin light chain B; clathrin, light chain (Lcb); clathrin, light polypeptide B (light chain B); lcb", "tax_id": 9913, "disease": "", "pathway": " (bta:281698); (R-BTA-190873); (R-BTA-196025); (R-BTA-432720); (R-BTA-5099900); (R-BTA-5140745); (R-BTA-8856825); (R-BTA-8856828)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "12426379;16460735;20033059;2434865;2930486;3128543;3821891", "class_list": "", "function": "Based on circular dichroism data, mapping and mutagenesis, bovine LCa and LCb were represented as alpha-helices, aligned along the heavy chain. A structural model of the interaction was generated with new implications for LC control of clathrin assembly., [RefSeq, PubMed]; CLTLB purified from bovine brain postmicrotubule supernatant and identified by mass spectrometry potently inhibited a catalytic activity of a major protein phosphatase (PP) that was copurified with microtubules and recognized by antiPP1 antibodies, [RefSeq, PubMed]; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Structure of clathrin coat with bound Hsc70 and auxilin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0030118 clathrin coat;GO:0030125 clathrin vesicle coat;GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0030130 clathrin coat of trans-Golgi network vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0072583 clathrin-dependent endocytosis;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04975-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15101-1", "uniprot_id": [ { "id": "DOPO_BOVIN", "url": "https://www.uniprot.org/uniprot/P15101", "type": "external" } ], "mass": 68141.0, "length": 610, "protein_name": "Dopamine beta-hydroxylase", "gene_name": "DBH", "organism": "Bovine", "refseq_name": "dopamine beta-hydroxylase precursor", "refseq_ac": [ { "id": "NP_851338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851338", "type": "external" } ], "gene_names_uniprotkb": "DBH", "gene_names_refseq": "DBH", "protein_names_uniprotkb": "Dopamine beta-hydroxylase; 1.14.17.1; Dopamine beta-monooxygenase", "protein_names_refseq": "dopamine beta-hydroxylase precursor; dopamine beta-monooxygenase", "tax_id": 9913, "disease": "", "pathway": " (bta:280758); (R-BTA-209905)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12379149;12966104;16305752;1688549;1693949;2207088;2295597;2555337;2620060;2909511;4525162;7918370;843373", "class_list": "", "function": "Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase, [RefSeq, PubMed]; The present study presents evidence for the conclusion that the catalytic activity of dopamine beta-hydroxylase (DBH; dopamine beta-mono-oxygenase, EC 1.14.17.1) is regulated independently by pH and by anions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8A8;Q28094;Q9TVD1", "ec_number_list": [ { "id": "1.14.17.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.17.1", "type": "external" } ], "go_molecular_function": "GO:0005507 copper ion binding;GO:0031418 L-ascorbic acid binding;GO:0004500 dopamine beta-monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034774 secretory granule lumen;GO:0030658 transport vesicle membrane;GO:0030667 secretory granule membrane;GO:0042584 chromaffin granule membrane", "go_biological_process": "GO:0042420 dopamine catabolic process;GO:0006589 octopamine biosynthetic process;GO:0042421 norepinephrine biosynthetic process;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P15101-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29172-1", "uniprot_id": [ { "id": "TAU_BOVIN", "url": "https://www.uniprot.org/uniprot/P29172", "type": "external" } ], "mass": 46333.0, "length": 448, "protein_name": "Microtubule-associated protein tau", "gene_name": "MAPT", "organism": "Bovine", "refseq_name": "microtubule-associated protein tau", "refseq_ac": [ { "id": "NP_776531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776531", "type": "external" } ], "gene_names_uniprotkb": "MAPT; TAU", "gene_names_refseq": "MAPT; tau", "protein_names_uniprotkb": "Microtubule-associated protein tau; Neurofibrillary tangle protein; PHF-tau; Paired helical filament-tau", "protein_names_refseq": "PHF-tau; microtubule-associated protein tau; neurofibrillary tangle protein; paired helical filament-tau", "tax_id": 9913, "disease": "", "pathway": " (bta:281296)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21267651;22403409;23434582;2498649;2498650;27452526;8455212;8910513", "class_list": "", "function": "Findings suggest that the endothelin-1-induced down-regulation of NaV1.7 (SCN9A) diminishes NaV1.7-related catecholamine secretion and dephosphorylation of tau., [RefSeq, PubMed]; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization., [UniProtKB]; Show that cathepsin D cleaves both tau and beta-amyloid precursor protein (APP). Both tau and APP are involved in the pathogenesis of Alzheimer's disease, [RefSeq, PubMed]; The energy landscape of Tau-mediated, GTP-dependent 'active' microtubule bundles, is reported. Publication Status: Online-Only, [RefSeq, PubMed]; The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 41, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P29173;Q28185;Q28186;Q28187;Q28188;Q28189;Q28190;Q32KT2", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P29172-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62803-1", "uniprot_id": [ { "id": "H4_BOVIN", "url": "https://www.uniprot.org/uniprot/P62803", "type": "external" } ], "mass": 11367.0, "length": 103, "protein_name": "Histone H4", "gene_name": "H4C16", "organism": "Bovine", "refseq_name": "H4 clustered histone 4", "refseq_ac": [ { "id": "NP_001093194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093194", "type": "external" } ], "gene_names_uniprotkb": "H4C16; H4-16", "gene_names_refseq": "H4C4", "protein_names_uniprotkb": "Histone H4; H4.1", "protein_names_refseq": "H4 clustered histone 4; histone H4-like", "tax_id": 9913, "disease": "", "pathway": " (bta:115945166); (bta:115945168); (bta:115945170); (bta:115945172); (bta:280691); (bta:516742); (bta:518961); (bta:526789); (bta:527388); (bta:527645); (bta:528329); (bta:530773); (bta:617875); (bta:617905); (R-BTA-110330); (R-BTA-110331); (R-BTA-171306); (R-BTA-201722); (R-BTA-212300); (R-BTA-2299718); (R-BTA-2559580); (R-BTA-2559582); (R-BTA-2559586); (R-BTA-3214815); (R-BTA-3214841); (R-BTA-3214842); (R-BTA-3214847); (R-BTA-3214858); (R-BTA-427359); (R-BTA-427413); (R-BTA-4551638); (R-BTA-5250924); (R-BTA-5578749); (R-BTA-5625886); (R-BTA-5693565); (R-BTA-5693571); (R-BTA-5693607); (R-BTA-606279); (R-BTA-68616); (R-BTA-69473); (R-BTA-73728); (R-BTA-73772); (R-BTA-8936459); (R-BTA-9018519); (R-BTA-9670095); (R-BTA-9764725); (R-BTA-9841922); (R-BTA-9843940); (R-BTA-9843970); (R-BTA-9909649); (R-BTA-9940951); (R-BTA-9943411); (R-BTA-9943962); (R-BTA-9970672)", "pathway_count": 54, "publication_count": 5, "publication_id_list": "10878337;4321977;5780842;5817359;9524213", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJ80;A5PK53;A8QFF4;P02304;P02305", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62803-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08168-1", "uniprot_id": [ { "id": "ARRS_BOVIN", "url": "https://www.uniprot.org/uniprot/P08168", "type": "external" } ], "mass": 45275.0, "length": 404, "protein_name": "S-arrestin", "gene_name": "SAG", "organism": "Bovine", "refseq_name": "S-arrestin", "refseq_ac": [ { "id": "NP_851343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851343", "type": "external" } ], "gene_names_uniprotkb": "SAG", "gene_names_refseq": "S-AG; SAG", "protein_names_uniprotkb": "S-arrestin; 48 kDa protein; Retinal S-antigen; Rod photoreceptor arrestin; S-AG", "protein_names_refseq": "48 kDa protein; S-antigen; S-arrestin; arrestin1; retina and pineal gland (arrestin); retinal S-antigen; rod photoreceptor arrestin", "tax_id": 9913, "disease": "", "pathway": " (bta:280922); (R-BTA-2514859)", "pathway_count": 2, "publication_count": 32, "publication_id_list": "10219246;1343765;1379981;15969447;1692780;1696531;1701801;1712808;1723632;21288033;22275358;22306737;2344622;23604253;2444731;2468451;24724832;2478582;25205354;26510463;2790968;28220785;2910351;2950857;30679635;3080338;3478675;7515057;7693817;8003967;8495487;9495348", "class_list": "", "function": "Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G proteins by competing with G proteins for the same binding site on RHO (PubMed:25205354, PubMed:8003967). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Conformational changes are involved in the arrestin-rhodopsin binding interface through multiple docking modes., [RefSeq, PubMed]; Data indicate molecular dynamics simulations and site-directed fluorescence experiments on arrestin-1 interactions with rhodopsin, showing that loops within the C-edge of arrestin function as a membrane anchor. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest functionality for mutant R171 in stabilizing the inactive arrestin-1 conformation as well as the rhodopsin-arrestin-1 complex. Publication Status: Online-Only, [RefSeq, PubMed]; K2A mutations in arrestin-1, -2, and -3 significantly reduced their binding to active phosphorhodopsin., [RefSeq, PubMed]; Maintenance of low levels of the active monomer is the biological role of arrestin-1 self-association, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0001664 G protein-coupled receptor binding;GO:0051219 phosphoprotein binding;GO:0002046 opsin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007165 signal transduction;GO:0007600 sensory perception;GO:0002031 G protein-coupled receptor internalization;GO:0009416 response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P08168-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q10741-1", "uniprot_id": [ { "id": "ADA10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q10741", "type": "external" } ], "mass": 84188.0, "length": 748, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "organism": "Bovine", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 10 preproprotein", "refseq_ac": [ { "id": "NP_776921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776921", "type": "external" } ], "gene_names_uniprotkb": "ADAM10; MADM", "gene_names_refseq": "ADAM 10; ADAM10", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 10; 3.4.24.81; ADAM 10; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; Myelin-associated metalloproteinase", "protein_names_refseq": "disintegrin and metalloproteinase domain-containing protein 10 preproprotein; disintegrin and metalloproteinase domain-containing protein 10; kuzbanian protein homolog; mammalian disintegrin-metalloprotease; myelin-associated metalloproteinase", "tax_id": 9913, "disease": "", "pathway": " (bta:282132); (R-BTA-1474228); (R-BTA-381426); (R-BTA-6798695); (R-BTA-8957275)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10097139;11481247;16239146;16777847;18381078;21325636;23035126;27503072;8694785", "class_list": "", "function": "Data show that ADAM10 and APLP2 are expressed in proximal tubule cells, and that ADAM10 activity has a pronounced effect on expression of specific brush-border proteins., [RefSeq, PubMed]; Intracellular trafficking of ADAM10 critically requires a novel sorting signal within its cytoplasmic domain., [RefSeq, PubMed]; N-glycosylation is crucial for ADAM10 processing and resistance to proteolysis, and results suggest that it is required for full-enzyme activity., [RefSeq, PubMed]; Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis. Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity (By similarity). Cleaves the membrane-bound precursor of TNF at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:10097139). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (By similarity). Also controls the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Required for the development of type 1 transitional B cells into marginal zone B cells, probably by cleaving Notch (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (By similarity). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (By similarity). Regulates leukocyte transmigration as a sheddase for the adherens junction protein VE-cadherin/CDH5 in endothelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A8E663", "ec_number_list": [ { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0017124 SH3 domain binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005886 plasma membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006509 membrane protein ectodomain proteolysis;GO:0007162 negative regulation of cell adhesion;GO:0007219 Notch signaling pathway;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q10741-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28056-1", "uniprot_id": [ { "id": "ASPH_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28056", "type": "external" } ], "mass": 84999.0, "length": 754, "protein_name": "Aspartyl/asparaginyl beta-hydroxylase", "gene_name": "ASPH", "organism": "Bovine", "refseq_name": "aspartyl/asparaginyl beta-hydroxylase", "refseq_ac": [ { "id": "NP_777182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777182", "type": "external" } ], "gene_names_uniprotkb": "ASPH", "gene_names_refseq": "ASPH", "protein_names_uniprotkb": "Aspartyl/asparaginyl beta-hydroxylase; 1.14.11.16; ASP beta-hydroxylase; Aspartate beta-hydroxylase; Peptide-aspartate beta-dioxygenase", "protein_names_refseq": "ASP beta-hydroxylase; aspartyl/asparaginyl beta-hydroxylase; peptide-aspartate beta-dioxygenase", "tax_id": 9913, "disease": "", "pathway": " (bta:286771); (R-BTA-2672351); (R-BTA-5578775)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "1378441;1856229", "class_list": "", "function": "Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.22", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.14.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.16", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0062101 peptidyl-aspartic acid 3-dioxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane;GO:0005886 plasma membrane;GO:0032541 cortical endoplasmic reticulum", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:0045862 positive regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28056-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11024-1", "uniprot_id": [ { "id": "NNTM_BOVIN", "url": "https://www.uniprot.org/uniprot/P11024", "type": "external" } ], "mass": 113854.0, "length": 1086, "protein_name": "NAD(P) transhydrogenase, mitochondrial", "gene_name": "NNT", "organism": "Bovine", "refseq_name": "NAD(P) transhydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776368", "type": "external" } ], "gene_names_uniprotkb": "NNT", "gene_names_refseq": "NNT", "protein_names_uniprotkb": "NAD(P) transhydrogenase, mitochondrial; 7.1.1.1; Nicotinamide nucleotide transhydrogenase; Pyridine nucleotide transhydrogenase", "protein_names_refseq": "NAD(P) transhydrogenase, mitochondrial precursor; NAD(P) transhydrogenase, mitochondrial; pyridine nucleotide transhydrogenase", "tax_id": 9913, "disease": "", "pathway": " (bta:280878); (R-BTA-71403)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10581554;2005110;28100784;3196335;3277960;3325062;3426633", "class_list": "", "function": "The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4FUB4", "ec_number_list": [ { "id": "7.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.1", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0050661 NADP binding;GO:0008750 proton-translocating NAD(P)+ transhydrogenase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0072593 reactive oxygen species metabolic process;GO:0006740 NADPH regeneration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P11024-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20000-1", "uniprot_id": [ { "id": "ALDH2_BOVIN", "url": "https://www.uniprot.org/uniprot/P20000", "type": "external" } ], "mass": 56653.0, "length": 520, "protein_name": "Aldehyde dehydrogenase, mitochondrial", "gene_name": "ALDH2", "organism": "Bovine", "refseq_name": "aldehyde dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001068835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068835", "type": "external" } ], "gene_names_uniprotkb": "ALDH2", "gene_names_refseq": "ALDH2", "protein_names_uniprotkb": "Aldehyde dehydrogenase, mitochondrial; 1.2.1.3; ALDH class 2; ALDH-E2; ALDHI", "protein_names_refseq": "ALDH class 2; ALDH-E2; ALDHI; aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase, mitochondrial precursor; aldehyde dehydrogenase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:508629); (R-BTA-380612); (R-BTA-71384); (R-BTA-9837999)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "1449496;1689984;18450747;2540003;27679490;27918674;9195888", "class_list": "", "function": "ACADM and ALDH2 were predicted to be the target genes of miR-224, [RefSeq, PubMed]; ALDH2-catalyzed NO formation is necessary and sufficient for nitroglycerin bioactivation in vascular smooth muscle cells., [RefSeq, PubMed]; Analysis of bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases ALDH1 and ALDH2, [RefSeq, PubMed]; Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZC6", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0106435 carboxylesterase activity;GO:0008957 phenylacetaldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006068 ethanol catabolic process;GO:0046185 aldehyde catabolic process;GO:0006067 ethanol metabolic process;GO:1905627 regulation of serotonin biosynthetic process;GO:0018937 nitroglycerin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P20000-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24627-1", "uniprot_id": [ { "id": "TRFL_BOVIN", "url": "https://www.uniprot.org/uniprot/P24627", "type": "external" } ], "mass": 78056.0, "length": 708, "protein_name": "Lactotransferrin", "gene_name": "LTF", "organism": "Bovine", "refseq_name": "lactotransferrin precursor", "refseq_ac": [ { "id": "NP_851341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851341", "type": "external" } ], "gene_names_uniprotkb": "LTF", "gene_names_refseq": "LTF; Lf", "protein_names_uniprotkb": "Lactotransferrin; 3.4.21.-; Lactoferrin", "protein_names_refseq": "lactoferrin; lactotransferrin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280846); (R-BTA-6798695); (R-BTA-6799990); (R-BTA-6803157)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "14650542;15166119;15222473;1599934;1718281;2001696;20345905;23662732;2805645;30761635;31570109;31678680;32242775;36385664;8206385;8980754;9254046;9398529;9521752", "class_list": "", "function": "Bovine Lactoferrin can Decrease the In Vitro Biofilm Production and Show Synergy with Antibiotics Against Listeria and Escherichia coli Isolates., [RefSeq, PubMed]; Has opioid antagonist activity. Shows higher degrees of preference for kappa-receptors than for mu-receptors., [UniProtKB, UniProtKB]; Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Lactoferrin derived from bovine milk was internalized by rectal epithelial cells and translocated to the nuclei. Moreover, nuclear translocation of bLF was significantly enhanced when the epithelial cells were inoculated with EHEC, as demonstrated by confocal fluorescence microscopy and confirmed by Raman microscopy and 3D imaging. Publication Status: Online-Only, [RefSeq, PubMed]; Lactoferrin gene polymorphisms associated with clinical mastitis in Honduran Holstein inheritance cows., [RefSeq, PubMed]; Major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection. Can inhibit papillomavirus infections. Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling. Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells. Stimulates VEGFA-mediated endothelial cell migration and proliferation. Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs). Also binds specifically to pneumococcal surface protein A (PspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA., [UniProtKB, UniProtKB]; Native and iron-saturated bovine lactoferrin differently hinder migration in a model of human glioblastoma by reverting epithelial-to-mesenchymal transition-like process and inhibiting interleukin-6/STAT3 axis., [RefSeq, PubMed]; Results provide evidence that LTF possess metal-dependent DNase and metal-independent RNase activities. The discovery of LF nuclease activities may contribute to understanding the multiple physiological functions of this extremely polyfunctional LF including its protective role against microbial and viral infections., [RefSeq, PubMed]; The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 13, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 30, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q1JQC9;Q29629;Q6LEC7;Q9MZY3", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0005506 iron ion binding;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0042581 specific granule", "go_biological_process": "GO:0006508 proteolysis;GO:0019731 antibacterial humoral response;GO:0019732 antifungal humoral response;GO:0043066 negative regulation of apoptotic process;GO:0033690 positive regulation of osteoblast proliferation", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "P24627-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62958-1", "uniprot_id": [ { "id": "HINT1_BOVIN", "url": "https://www.uniprot.org/uniprot/P62958", "type": "external" } ], "mass": 13779.0, "length": 126, "protein_name": "Adenosine 5'-monophosphoramidase HINT1", "gene_name": "HINT1", "organism": "Bovine", "refseq_name": "adenosine 5'-monophosphoramidase HINT1", "refseq_ac": [ { "id": "NP_787006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787006", "type": "external" } ], "gene_names_uniprotkb": "HINT1; HINT; PKCI1", "gene_names_refseq": "HINT1", "protein_names_uniprotkb": "Adenosine 5'-monophosphoramidase HINT1; 17 kDa inhibitor of protein kinase C; 3.4.22.-; 3.9.1.-; Desumoylating isopeptidase HINT1; Histidine triad nucleotide-binding protein 1; PKCI-1; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1", "protein_names_refseq": "17 kDa inhibitor of protein kinase C; PKCI-1; adenosine 5'-monophosphoramidase HINT1; adenosine 5'-monophosphoramidase; desumoylating isopeptidase HINT1; protein kinase C inhibitor 1; protein kinase C-interacting protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:327693)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1472710;1899836;2307677", "class_list": "", "function": "Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (By similarity). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (By similarity). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (By similarity). In addition, functions as a scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (By similarity). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RANGAP1 and RGS17 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P16436;Q3T060", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "2.7.7.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.51", "type": "external" }, { "id": "3.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0016787 hydrolase activity;GO:0000166 nucleotide binding;GO:0043530 adenosine 5'-monophosphoramidase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0006355 regulation of DNA-templated transcription;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator;GO:0009154 purine ribonucleotide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62958-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48644-1", "uniprot_id": [ { "id": "AL1A1_BOVIN", "url": "https://www.uniprot.org/uniprot/P48644", "type": "external" } ], "mass": 54806.0, "length": 501, "protein_name": "Aldehyde dehydrogenase 1A1", "gene_name": "ALDH1A1", "organism": "Bovine", "refseq_name": "aldehyde dehydrogenase 1A1", "refseq_ac": [ { "id": "NP_776664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776664", "type": "external" } ], "gene_names_uniprotkb": "ALDH1A1", "gene_names_refseq": "ALDH1A1; ALDH1", "protein_names_uniprotkb": "Aldehyde dehydrogenase 1A1; 1.2.1.19; 1.2.1.28; 1.2.1.36; 1.2.1.3; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; RALDH 1; RalDH1; Retinal dehydrogenase 1", "protein_names_refseq": "3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; RALDH 1; aldehyde dehydrogenase 1, soluble; aldehyde dehydrogenase 1A1; aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase, cytosolic; ralDH1; retinal dehydrogenase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:281615); (R-BTA-5365859); (R-BTA-70350); (R-BTA-71384)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "16305752;18450747;31646946;7786847", "class_list": "", "function": "ALDH1A1 effect on Yan Yellow Cattle preadipocyte differentiation., [RefSeq, PubMed]; Analysis of bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases ALDH1 and ALDH2, [RefSeq, PubMed]; Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:7786847). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (PubMed:7786847). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (Probable). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7E3P6;Q3MHL5", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0018479 benzaldehyde dehydrogenase (NAD+) activity;GO:0019145 aminobutyraldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030424 axon;GO:0045202 synapse", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0006081 aldehyde metabolic process;GO:0042572 retinol metabolic process;GO:0036438 maintenance of lens transparency;GO:0009449 gamma-aminobutyric acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P48644-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28175-1", "uniprot_id": [ { "id": "RPE65_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28175", "type": "external" } ], "mass": 60970.0, "length": 533, "protein_name": "Retinoid isomerohydrolase", "gene_name": "RPE65", "organism": "Bovine", "refseq_name": "retinoid isomerohydrolase", "refseq_ac": [ { "id": "NP_776878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776878", "type": "external" } ], "gene_names_uniprotkb": "RPE65", "gene_names_refseq": "RPE65", "protein_names_uniprotkb": "Retinoid isomerohydrolase; 3.1.1.64; 5.3.3.22; All-trans-retinyl-palmitate hydrolase; Lutein isomerase; Meso-zeaxanthin isomerase; Retinal pigment epithelium-specific 65 kDa protein; Retinol isomerase", "protein_names_refseq": "RPE65, retinoid isomerohydrolase; all-trans-retinyl-palmitate hydrolase; lutein isomerase; meso-zeaxanthin isomerase; retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein (65kD); retinal pigment epithelium-specific protein 65kDa; retinoid isomerohydrolase; retinol isomerase", "tax_id": 9913, "disease": "", "pathway": " (bta:282043)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12755618;14529294;15186777;16096063;16379027;19049981;19805034;19892706;20100834;20510285;23012475;30914787;8340400;8397208", "class_list": "", "function": "Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16096063, PubMed:19805034, PubMed:20100834). Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (PubMed:15186777)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Data indicate that Structural differences between delipidated and nondelipidated RPE65 uncovered key residues involved in substrate uptake and processing., [RefSeq, PubMed]; Oxidative stress during the visual cycle results in cleavage of RPE65, [RefSeq, PubMed]; Quenching of protein fluorescence is used to demonstrate quantitatively that RPE65 functions by binding to and mobilizing the highly hydrophobic all-trans-retinyl esters, allowing them to enter the visual cycle. Erratum:[Biochemistry. 2004 Jun 8;43(22):7226], [RefSeq, PubMed]; Retinoid binding role for RPE65, [RefSeq, PubMed]; Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups., [RefSeq, PubMed]; The dual roles of RPE65 S-palmitoylation in membrane association and visual cycle function. Publication Status: Online-Only, [RefSeq, PubMed]; The enzymatic activity of native RPE65 strongly depends on its membrane binding and phospholipid environment, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A140T8B8;Q05661", "ec_number_list": [ { "id": "3.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.64", "type": "external" }, { "id": "5.3.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.22", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0031210 phosphatidylcholine binding;GO:0001786 phosphatidylserine binding;GO:0003834 beta-carotene 15,15'-dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001895 retina homeostasis;GO:0042574 retinal metabolic process;GO:0050908 detection of light stimulus involved in visual perception;GO:1901827 zeaxanthin biosynthetic process;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q28175-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21793-1", "uniprot_id": [ { "id": "PGS2_BOVIN", "url": "https://www.uniprot.org/uniprot/P21793", "type": "external" } ], "mass": 39879.0, "length": 360, "protein_name": "Decorin", "gene_name": "DCN", "organism": "Bovine", "refseq_name": "decorin precursor", "refseq_ac": [ { "id": "NP_776331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776331", "type": "external" } ], "gene_names_uniprotkb": "DCN", "gene_names_refseq": "DCN", "protein_names_uniprotkb": "Decorin; Bone proteoglycan II; PG-S2", "protein_names_refseq": "PG-S2; bone proteoglycan II; decorin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280760); (R-BTA-1474228); (R-BTA-1971475); (R-BTA-2022870); (R-BTA-2022923); (R-BTA-2024101); (R-BTA-3000178)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "11723132;12658628;15501918;16305752;20386503;21659473;23608680;25012297;2914936;30022402;3435485;3936484;6654908;8907183;9895299", "class_list": "", "function": "Data show that biglycan, collagen type I, collagen type II, decorin, and versican were significantly affected by vibration duration, frequency, and amplitude., [RefSeq, PubMed]; Downregulation associated with proliferation, remodeling and vascularization of placental tissues, [RefSeq, PubMed]; May affect the rate of fibrils formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The concentration of decorin is gestation time-dependent in healthy bovine placenta., [RefSeq, PubMed]; The inclusion of decorin proteoglycan during fibrillogenesis of type I collagen increases the modulus and tensile strength of resulting collagen gels., [RefSeq, PubMed]; These findings reveal a novel role of DCN as an antagonistic ligand for VEGFR-2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3MHN1;Q5U7W0;Q861V7;Q862D9;Q862E8;Q862L4;Q862R5", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005539 glycosaminoglycan binding;GO:0098633 collagen fibril binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0010508 positive regulation of autophagy;GO:1904027 negative regulation of collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P21793-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12624-1", "uniprot_id": [ { "id": "MARCS_BOVIN", "url": "https://www.uniprot.org/uniprot/P12624", "type": "external" } ], "mass": 31665.0, "length": 333, "protein_name": "Myristoylated alanine-rich C-kinase substrate", "gene_name": "MARCKS", "organism": "Bovine", "refseq_name": "myristoylated alanine-rich C-kinase substrate", "refseq_ac": [ { "id": "NP_001069744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069744", "type": "external" } ], "gene_names_uniprotkb": "MARCKS; MACS", "gene_names_refseq": "ACAMP-81; MARCKS", "protein_names_uniprotkb": "Myristoylated alanine-rich C-kinase substrate; ACAMP-81; MARCKS", "protein_names_refseq": "myristoylated alanine-rich C-kinase substrate", "tax_id": 9913, "disease": "", "pathway": " (bta:613548)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "1396720;1540183;1560845;18799624;18977358;2034276;22773836;22927426;2473066;2726763;2734111;8034575;8463217", "class_list": "", "function": "A critical role for H(2)O(2) in angiotensin-II signaling to the endothelial cytoskeleton in a novel pathway that is critically dependent on MARCKS, Rac1, and c-Abl., [RefSeq, PubMed]; MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability., [RefSeq, PubMed]; Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes. Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis. During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (By similarity). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Protein kinase C mediated inhibition of endothelial L-arginine transport is mediated by MARCKS protein, [RefSeq, PubMed]; These findings demonstrate a critical role for MARCKS-phosphatidylinositol-4,5-diphosphate signaling in regulating dendrite development., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZI0", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0005080 protein kinase C binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0032432 actin filament bundle", "go_biological_process": "GO:0007015 actin filament organization;GO:0006915 apoptotic process;GO:0007417 central nervous system development;GO:0051017 actin filament bundle assembly;GO:0021915 neural tube development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P12624-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12344-1", "uniprot_id": [ { "id": "AATM_BOVIN", "url": "https://www.uniprot.org/uniprot/P12344", "type": "external" } ], "mass": 47514.0, "length": 430, "protein_name": "Aspartate aminotransferase, mitochondrial", "gene_name": "GOT2", "organism": "Bovine", "refseq_name": "aspartate aminotransferase, mitochondrial", "refseq_ac": [ { "id": "NP_777231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777231", "type": "external" } ], "gene_names_uniprotkb": "GOT2", "gene_names_refseq": "GOT2", "protein_names_uniprotkb": "Aspartate aminotransferase, mitochondrial; 2.6.1.1; FABP-1; FABPpm; Fatty acid-binding protein; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; Transaminase A; mAspAT", "protein_names_refseq": "FABP-1; FABPpm; aspartate aminotransferase 2; aspartate aminotransferase, mitochondrial; fatty acid-binding protein; glutamate oxaloacetate transaminase 2; kynurenine aminotransferase 4; kynurenine aminotransferase IV; kynurenine--oxoglutarate transaminase 4; kynurenine--oxoglutarate transaminase IV; mAspAT; plasma membrane-associated fatty acid-binding protein; transaminase A", "tax_id": 9913, "disease": "", "pathway": " (bta:286886); (R-BTA-389661); (R-BTA-8963693); (R-BTA-8964539); (R-BTA-9856872)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "16305752;22076378;28100784;446759;7641080;965157", "class_list": "", "function": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D967;Q3T0Q1", "ec_number_list": [ { "id": "2.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.1", "type": "external" }, { "id": "2.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.3", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006533 L-aspartate catabolic process;GO:0006536 glutamate metabolic process;GO:0006869 lipid transport;GO:0006531 aspartate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P12344-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10522-1", "uniprot_id": [ { "id": "MYP0_BOVIN", "url": "https://www.uniprot.org/uniprot/P10522", "type": "external" } ], "mass": 27452.0, "length": 248, "protein_name": "Myelin protein P0", "gene_name": "MPZ", "organism": "Bovine", "refseq_name": "myelin protein P0 isoform MPZ precursor", "refseq_ac": [ { "id": "NP_001072975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072975", "type": "external" } ], "gene_names_uniprotkb": "MPZ", "gene_names_refseq": "MPZ", "protein_names_uniprotkb": "Myelin protein P0; MPP; Myelin peripheral protein; Myelin protein zero", "protein_names_refseq": "MPP; myelin peripheral protein; myelin protein P0 isoform MPZ precursor; myelin protein P0; myelin protein zero (Charcot-Marie-Tooth neuropathy 1B)", "tax_id": 9913, "disease": "", "pathway": " (bta:539462)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1700069;2435734;8808799", "class_list": "", "function": "Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05B76", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0042552 myelination;GO:0098609 cell-cell adhesion;GO:0098743 cell aggregation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P10522-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35705-1", "uniprot_id": [ { "id": "PRDX3_BOVIN", "url": "https://www.uniprot.org/uniprot/P35705", "type": "external" } ], "mass": 28195.0, "length": 257, "protein_name": "Thioredoxin-dependent peroxide reductase, mitochondrial", "gene_name": "PRDX3", "organism": "Bovine", "refseq_name": "thioredoxin-dependent peroxide reductase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776857", "type": "external" } ], "gene_names_uniprotkb": "PRDX3; AOP1", "gene_names_refseq": "MTAP; PRDX3", "protein_names_uniprotkb": "Thioredoxin-dependent peroxide reductase, mitochondrial; 1.11.1.24; AOP-1; Antioxidant protein 1; Peroxiredoxin-3; Protein SP-22; Thioredoxin-dependent peroxiredoxin 3", "protein_names_refseq": "5'-methylthioadenosine phosphorylase; AOP-1; MTA phosphorylase; MTAPase; antioxidant protein 1; thioredoxin-dependent peroxide reductase, mitochondrial precursor; thioredoxin-dependent peroxide reductase, mitochondrial; thioredoxin-dependent peroxiredoxin 3", "tax_id": 9913, "disease": "", "pathway": " (bta:281998); (R-BTA-3299685)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12773537;16271889;22823939;25906064;8089078;8912927", "class_list": "", "function": "Data suggest that during ectogenesis of blastocysts infected with bovine Herpesvirus type 5, expression of AOP-1 is induced; this effect may be involved in inhibition of apoptosis in infected blastocysts/embryos. Publication Status: Online-Only, [RefSeq, PubMed]; PRDX3, also known as SP-22, is a mitochondrial 2-CYS peroxiredoxin organized as a decameric toroid, [RefSeq, PubMed]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (By similarity). Required for the maintenance of physical strength (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZA8", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0008379 thioredoxin peroxidase activity;GO:0140824 thioredoxin-dependent peroxiredoxin activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005769 early endosome;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0051881 regulation of mitochondrial membrane potential;GO:0042542 response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35705-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04272-1", "uniprot_id": [ { "id": "ANXA2_BOVIN", "url": "https://www.uniprot.org/uniprot/P04272", "type": "external" } ], "mass": 38612.0, "length": 339, "protein_name": "Annexin A2", "gene_name": "ANXA2", "organism": "Bovine", "refseq_name": "annexin A2", "refseq_ac": [ { "id": "NP_777141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777141", "type": "external" } ], "gene_names_uniprotkb": "ANXA2; ANX2", "gene_names_refseq": "ANXA2", "protein_names_uniprotkb": "Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; PAP-IV; Placental anticoagulant protein IV; Protein I; p36", "protein_names_refseq": "PAP-IV; annexin A2; annexin II; annexin-2; calpactin I heavy chain; calpactin-1 heavy chain; chromobindin-8; lipocortin II; p36; placental anticoagulant protein IV; protein I", "tax_id": 9913, "disease": "", "pathway": " (bta:282689); (R-BTA-6798695); (R-BTA-75205); (R-BTA-9860927)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "16305752;26323692;28102235;28771726;2942542;2945590;30610889;34331392", "class_list": "", "function": "Annexin A2-induced actin bundling is apparently essential for generating active exocytotic sites., [RefSeq, PubMed]; AnxA2 functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c/Cyclin D1 signaling pathway., [RefSeq, PubMed]; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; ClfA binds with AnnexinA2 and this interaction could mediate S. aureus invasion into bovine mammary epithelial cells. Publication Status: Online-Only, [RefSeq, PubMed]; Dephosphorylation of annexin A2 by protein phosphatase 1 regulates endothelial cell barrier., [RefSeq, PubMed]; Expression of AnxA2-Y23A inhibited the formation of lipid microdomains, whereas the expression of AnxA2-Y23E altered actin filaments associated with docked granules. These results suggest that phosphorylation/dephosphorylation switch at Tyr23 in AnxA2 is critical for calcium-regulated exocytosis in neuroendocrine cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCC7;Q5E9B0", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005509 calcium ion binding;GO:0008092 cytoskeletal protein binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0065010 extracellular membrane-bounded organelle;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0007155 cell adhesion;GO:0031214 biomineral tissue development;GO:0070588 calcium ion transmembrane transport;GO:0070509 calcium ion import", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P04272-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62808-1", "uniprot_id": [ { "id": "H2B1_BOVIN", "url": "https://www.uniprot.org/uniprot/P62808", "type": "external" } ], "mass": 13906.0, "length": 126, "protein_name": "Histone H2B type 1", "gene_name": "H2BC16", "organism": "Bovine", "refseq_name": "histone H2B type 1", "refseq_ac": [ { "id": "NP_001032546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032546", "type": "external" } ], "gene_names_uniprotkb": "H2BC16", "gene_names_refseq": "H2BC19; H2B", "protein_names_uniprotkb": "Histone H2B type 1", "protein_names_refseq": "histone H2B type 1; histone H2B-like", "tax_id": 9913, "disease": "", "pathway": " (bta:100295221); (bta:104968456); (bta:104975676); (bta:505183); (bta:506306); (bta:615043); (bta:616776); (bta:616868); (bta:787269); (bta:787465); (R-BTA-110330); (R-BTA-110331); (R-BTA-171306); (R-BTA-201722); (R-BTA-212300); (R-BTA-2299718); (R-BTA-2559580); (R-BTA-2559582); (R-BTA-2559586); (R-BTA-3214815); (R-BTA-3214847); (R-BTA-427359); (R-BTA-427413); (R-BTA-5250924); (R-BTA-5578749); (R-BTA-5625886); (R-BTA-5689880); (R-BTA-5693565); (R-BTA-5693571); (R-BTA-5693607); (R-BTA-606279); (R-BTA-68616); (R-BTA-69473); (R-BTA-73728); (R-BTA-73772); (R-BTA-8866654); (R-BTA-8936459); (R-BTA-9018519); (R-BTA-9670095); (R-BTA-9764725); (R-BTA-9841922); (R-BTA-9843940); (R-BTA-9843970); (R-BTA-9909649); (R-BTA-9940951); (R-BTA-9943411); (R-BTA-9943962); (R-BTA-9970672)", "pathway_count": 48, "publication_count": 5, "publication_id_list": "12777396;16305752;2713375;4644305;6320184", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1L599;A5PJG5;P02278;Q32PE8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0070062 extracellular exosome;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62808-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80025-1", "uniprot_id": [ { "id": "PERL_BOVIN", "url": "https://www.uniprot.org/uniprot/P80025", "type": "external" } ], "mass": 80642.0, "length": 712, "protein_name": "Lactoperoxidase", "gene_name": "LPO", "organism": "Bovine", "refseq_name": "lactoperoxidase precursor", "refseq_ac": [ { "id": "NP_776358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776358", "type": "external" } ], "gene_names_uniprotkb": "LPO", "gene_names_refseq": "LPO", "protein_names_uniprotkb": "Lactoperoxidase; 1.11.1.7; LPO", "protein_names_refseq": "lactoperoxidase precursor; lactoperoxydase", "tax_id": 9913, "disease": "", "pathway": " (bta:280844); (R-BTA-8941413)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10924350;11597409;11756449;19167310;19339248;20461536;2050150;22132121;2222811;22886082;24928513;28594102;33882424;354515;5338806;9083001;9774411", "class_list": "", "function": "Bovine LPO enzyme was effectively inhibited by phenolic molecules. Ki values of these natural products were found as 0.20 +/- 0.09, 0.22 +/- 0.17, 0.49 +/- 0.11, 0.49 +/- 0.27, and 1.20 +/- 0.25 muM, respectively. Tetrakis and digoxin exhibited noncompetitive inhibition, and other molecules showed competitive inhibition., [RefSeq, PubMed]; Establish urate as a likely physiological substrate for LPO that will influence host defense and give rise to reactive electrophilic metabolites, [RefSeq, PubMed]; Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (Probable) (PubMed:5338806). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (Probable) (PubMed:354515). Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism (PubMed:354515, PubMed:5338806). The lactoperoxidase-SCN(-)-H2O2 system shows antibacterial properties against some streptococci strains (PubMed:5338806). The lactoperoxidase-I(-)-H2O2 system shows antibacterial properties against E.coli (PubMed:354515). May protect the udder from infection and may promote growth in newborns (By similarity). May be implicated in airway host defense against infection (By similarity). May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; LPO serve as a catalytic sink for HOCl (hypochlorous acid), while HOCl serves to modulate LPO catalytic activity, bioavailability, and function., [RefSeq, PubMed]; Results describe the crystal structure of the complex of lactoperoxidase and 3-amino-1,2,4-triazole (amitrole), which revealed the presence of two ligand molecules, one in the substrate binding site and the second in the hydrophobic channel., [RefSeq, PubMed]; Studied the 3-dimensional structure of CO-LPO at 2.0A resolution and infrared (IR) spectra of the iron-bound CO stretch from pH 3 to 8.8 at 1 cm(-1) resolution., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0020037 heme binding;GO:0036393 thiocyanate peroxidase activity;GO:0004601 peroxidase activity;GO:0140825 lactoperoxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0019731 antibacterial humoral response;GO:0042742 defense response to bacterium;GO:0042744 hydrogen peroxide catabolic process;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P80025-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04752-1", "uniprot_id": [ { "id": "STF1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q04752", "type": "external" } ], "mass": 51613.0, "length": 461, "protein_name": "Steroidogenic factor 1", "gene_name": "NR5A1", "organism": "Bovine", "refseq_name": "steroidogenic factor 1", "refseq_ac": [ { "id": "NP_776828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776828", "type": "external" } ], "gene_names_uniprotkb": "NR5A1; AD4BP; FTZF1", "gene_names_refseq": "NR5A1; SF-1", "protein_names_uniprotkb": "Steroidogenic factor 1; Adrenal 4-binding protein; Fushi tarazu factor homolog 1; Nuclear receptor subfamily 5 group A member 1; SF-1; STF-1; Steroid hormone receptor Ad4BP", "protein_names_refseq": "STF-1; adrenal 4-binding protein; fushi tarazu factor homolog 1; steroid hormone receptor Ad4BP; steroidogenic factor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:281948); (R-BTA-383280); (R-BTA-4090294)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1406703;17176485;18409030;19455657;21622533;25726440;8463279", "class_list": "", "function": "GATA4 and GATA6 mRNA and proteins could be detected in bovine corpus luteum (CL). GATA6 showed a marked decrease at the regressed luteal stage, like NR5A1, NR5A2, and the other steroidogenic markers., [RefSeq, PubMed]; Involvement of Ad4BP/SF-1, DAX-1, and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells., [RefSeq, PubMed]; The SF-1 and beta-catenin pathway convergence on StarD7 expression may have important implications in the phospholipid uptake and transport, contributing to the normal trophoblast development., [RefSeq, PubMed]; The role of the NR5A1 activating functions AF-1 & AF-2 was studied in luteinizing bovine theca cells. The regulation of the 3 NR5A1-controlled genes CYPA11, STAR, & INSL3 apparently is not dependent on NR5A1 activating functions AF-1 or AF-2. Publication Status: Online-Only, [RefSeq, PubMed]; These results indicate that PCBs impair the secretory function of ovarian steroidogenic cells by disrupting steroidogenesis and increasing OT secretion, and the receptor SF-1 appears to be essentially involved in these processes., [RefSeq, PubMed]; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0007530 sex determination;GO:2000020 positive regulation of male gonad development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q04752-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10103-1", "uniprot_id": [ { "id": "HMGB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P10103", "type": "external" } ], "mass": 24908.0, "length": 215, "protein_name": "High mobility group protein B1", "gene_name": "HMGB1", "organism": "Bovine", "refseq_name": "high mobility group protein B1", "refseq_ac": [ { "id": "NP_788785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788785", "type": "external" } ], "gene_names_uniprotkb": "HMGB1; HMG1", "gene_names_refseq": "HMGB1", "protein_names_uniprotkb": "High mobility group protein B1; HMG-1; High mobility group protein 1", "protein_names_refseq": "HMG-1; high mobility group protein 1; high mobility group protein B1", "tax_id": 9913, "disease": "", "pathway": " (bta:282691); (R-BTA-140342); (R-BTA-3000471); (R-BTA-445989); (R-BTA-5620971); (R-BTA-5686938); (R-BTA-6798695); (R-BTA-879415); (R-BTA-933542)", "pathway_count": 9, "publication_count": 21, "publication_id_list": "14532127;16305752;16966386;17417641;18599803;20014975;21634123;22875364;22941653;23446148;23519706;2365081;23994764;25048472;26639899;31544976;3194213;34008469;6141822;7202717;7409193", "class_list": "", "function": "Beta-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture., [RefSeq, PubMed]; HMGB1 can act as an adjuvant in modulating the bovine immune system and thus lays a foundation for using HMGB1 as an adjuvant in various bovine vaccine preparations., [RefSeq, PubMed]; In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Involved in oxidative stress-mediated autophagy. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; In the extracellular compartment (following either active secretion or passive release)involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (By similarity). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (PubMed:16966386). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (By similarity). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways (PubMed:17417641). Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10. Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2. In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes. Contributes to tumor proliferation by association with ACER/RAGE. Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (By similarity). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells (PubMed:17417641). Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (PubMed:20014975). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells. In adaptive immunity may be involved in enhancing immunity through activation of effector T-cells and suppression of regulatory T (TReg) cells. In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression. Also reported to limit proliferation of T-cells. Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production. Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106. During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA. Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (PubMed:22941653). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities. Facilitates binding of TP53 to DNA. May be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1. Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Single-nucleotide polymorphism in the 3'-untranslated region of the HMGB1 gene affects the binding of target bta-miR-223 and is involved in mastitis., [RefSeq, PubMed]; The mechanisms of interaction of the non-histone chromosomal protein HMGB1 and linker histone H1 with DNA have been studied using circular dichroism and absorption spectroscopy., [RefSeq, PubMed]; Toll-like receptors and high mobility group box 1 in granulosa cells during bovine follicle maturation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D9G8;Q3ZC39", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0050786 RAGE receptor binding;GO:0042056 chemoattractant activity;GO:0003684 damaged DNA binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0000793 condensed chromosome", "go_biological_process": "GO:0002270 plasmacytoid dendritic cell activation;GO:0002840 regulation of T cell mediated immune response to tumor cell;GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0032727 positive regulation of interferon-alpha production;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P10103-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79106-1", "uniprot_id": [ { "id": "PAFA2_BOVIN", "url": "https://www.uniprot.org/uniprot/P79106", "type": "external" } ], "mass": 43865.0, "length": 392, "protein_name": "Platelet-activating factor acetylhydrolase 2, cytoplasmic", "gene_name": "PAFAH2", "organism": "Bovine", "refseq_name": "platelet-activating factor acetylhydrolase 2, cytoplasmic", "refseq_ac": [ { "id": "NP_776995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776995", "type": "external" } ], "gene_names_uniprotkb": "PAFAH2", "gene_names_refseq": "PAFAH2", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase 2, cytoplasmic; 2.3.1.149; 3.1.1.47; PAF acetylhydrolase II; PAF:lysophospholipid transacetylase; PAF:sphingosine transacetylase; Platelet-activating factor acetyltransferase PAFAH2; SD-PLA2; Serine-dependent phospholipase A2", "protein_names_refseq": "PAF acetylhydrolase II; PAF:lysophospholipid transacetylase; PAF:sphingosine transacetylase; SD-PLA2; platelet-activating factor acetylhydrolase 2, 40kDa; platelet-activating factor acetylhydrolase 2, cytoplasmic; platelet-activating factor acetyltransferase PAFAH2; serine-dependent phospholipase A2", "tax_id": 9913, "disease": "", "pathway": " (bta:282299); (R-BTA-418346)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16305752;7673213;8955149;9218411;9405438", "class_list": "", "function": "Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PubMed:7673213, PubMed:8955149, PubMed:9405438). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (PubMed:7673213). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5E9S1", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0047179 platelet-activating factor acetyltransferase activity;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P79106-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P67774-1", "uniprot_id": [ { "id": "PP2AA_BOVIN", "url": "https://www.uniprot.org/uniprot/P67774", "type": "external" } ], "mass": 35594.0, "length": 309, "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "gene_name": "PPP2CA", "organism": "Bovine", "refseq_name": "serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "refseq_ac": [ { "id": "NP_851374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851374", "type": "external" } ], "gene_names_uniprotkb": "PPP2CA", "gene_names_refseq": "PPP2CA", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; 3.1.3.16; PP2A-alpha", "protein_names_refseq": "PP2A-alpha; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "tax_id": 9913, "disease": "", "pathway": " (bta:282320); (R-BTA-113501); (R-BTA-1295596); (R-BTA-141430); (R-BTA-141444); (R-BTA-180024); (R-BTA-195253); (R-BTA-196299); (R-BTA-198753); (R-BTA-202670); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-2995383); (R-BTA-389356); (R-BTA-389513); (R-BTA-432142); (R-BTA-4641262); (R-BTA-5663220); (R-BTA-5673000); (R-BTA-5675221); (R-BTA-6804757); (R-BTA-6811558); (R-BTA-69231); (R-BTA-69273); (R-BTA-9648025); (R-BTA-975957); (R-BTA-9833482); (R-BTA-9860927)", "pathway_count": 28, "publication_count": 5, "publication_id_list": "24606881;26569399;3037526;7681598;8396127", "class_list": "", "function": "Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (By similarity). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as AXIN1, p53/TP53, PIM3, WEE1. Activates RAF1 by dephosphorylating it at 'Ser-259'. Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC. Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (By similarity). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promoting PIM3 ubiquitination and proteasomal degradation. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex. The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Changes in PP2A activity due to methylation and tyrosine phosphorylation occur in sperm; these changes may play an important role in the regulation of sperm function Publication Status: Online-Only, [RefSeq, PubMed]; The findings demonstrate an endothelial VEGF resistance mechanism conferred by palmitic acid, which comprises ceramide-induced, PP2A-mediated dephosphorylation of critical activation sites on enzymes central to vascular homeostasis and angiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QLI7;P05323;P13197", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.1.1.233", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.233", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.89", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0004722 protein serine/threonine phosphatase activity;GO:0050811 GABA receptor binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P67774-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15690-1", "uniprot_id": [ { "id": "NDUS1_BOVIN", "url": "https://www.uniprot.org/uniprot/P15690", "type": "external" } ], "mass": 79442.0, "length": 727, "protein_name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "gene_name": "NDUFS1", "organism": "Bovine", "refseq_name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor", "refseq_ac": [ { "id": "NP_777245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777245", "type": "external" } ], "gene_names_uniprotkb": "NDUFS1", "gene_names_refseq": "NDUFS1", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; 7.1.1.2; CI-75kD; Complex I-75kD", "protein_names_refseq": "CI-75kD; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase); NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; complex I-75kD", "tax_id": 9913, "disease": "", "pathway": " (bta:288380); (R-BTA-611105); (R-BTA-6799198); (R-BTA-9837999)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10852722;18721790;19961238;20513438;20599678;2514801;25209663", "class_list": "", "function": "Bovine heart NADH-ubiquinone oxidoreductase contains one molecule of ubiquinone with ten isoprene units as one of the cofactors, [RefSeq, PubMed]; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790). Essential for catalysing the entry and efficient transfer of electrons within complex I (By similarity). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Data show that during NADH-ubiquinone oxidoreductase (Complex I) catalytic electron transfer from NADH to DBQ, the superoxide generation site was mostly shifted to the SQ., [RefSeq, PubMed]; Data suggest that Q(Nf) plays a role in a 'direct' redox-driven proton pump, while Q(Ns) triggers an 'indirect' conformation-driven proton pump in NADH-ubiquinone oxidoreductase (complex I)., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VCP7", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042773 ATP synthesis coupled electron transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P15690-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05752-1", "uniprot_id": [ { "id": "NDUA7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05752", "type": "external" } ], "mass": 12677.0, "length": 113, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7", "gene_name": "NDUFA7", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7", "refseq_ac": [ { "id": "NP_788831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788831", "type": "external" } ], "gene_names_uniprotkb": "NDUFA7; CI-B14-5A", "gene_names_refseq": "NDUFA7", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7; CI-B14.5a; Complex I-B14.5a; NADH-ubiquinone oxidoreductase subunit B14.5a", "protein_names_refseq": "CI-B14.5a; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7; NADH-ubiquinone oxidoreductase subunit B14.5a; complex I-B14.5a", "tax_id": 9913, "disease": "", "pathway": " (bta:338063); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10852722;1426273;18721790;28100784", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H7C3", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042773 ATP synthesis coupled electron transport;GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q05752-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32871-1", "uniprot_id": [ { "id": "PK3CA_BOVIN", "url": "https://www.uniprot.org/uniprot/P32871", "type": "external" } ], "mass": 124328.0, "length": 1068, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "gene_name": "PIK3CA", "organism": "Bovine", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "refseq_ac": [ { "id": "NP_776999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776999", "type": "external" } ], "gene_names_uniprotkb": "PIK3CA", "gene_names_refseq": "PIK3CA", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; 2.7.1.137; 2.7.1.153; 2.7.11.1; PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; PtdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA; p110alpha", "protein_names_refseq": "PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PI3K; p110alpha; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase, catalytic, alpha polypeptide; ptdIns-3-kinase p110; ptdIns-3-kinase subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein kinase PIK3CA", "tax_id": 9913, "disease": "", "pathway": " (bta:282306); (R-BTA-109704); (R-BTA-112399); (R-BTA-114604); (R-BTA-1250342); (R-BTA-1257604); (R-BTA-1433557); (R-BTA-1660499); (R-BTA-180292); (R-BTA-186763); (R-BTA-1963642); (R-BTA-198203); (R-BTA-201556); (R-BTA-202424); (R-BTA-2029485); (R-BTA-210993); (R-BTA-2424491); (R-BTA-2730905); (R-BTA-389357); (R-BTA-416476); (R-BTA-4420097); (R-BTA-512988); (R-BTA-5654689); (R-BTA-5654695); (R-BTA-5654710); (R-BTA-5654720); (R-BTA-5673001); (R-BTA-6811558); (R-BTA-8851907); (R-BTA-8853659); (R-BTA-9009391); (R-BTA-9013404); (R-BTA-9027276); (R-BTA-912526); (R-BTA-912631); (R-BTA-9607240); (R-BTA-9927354)", "pathway_count": 37, "publication_count": 7, "publication_id_list": "1322797;14729945;15178440;16055506;17626883;24325755;26427433", "class_list": "", "function": "Crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains, [RefSeq, PubMed]; Data show that both class I and III phosphoinositide 3-kinases (PI3Ks) re present in trafficking vesicles., [RefSeq, PubMed]; Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:1322797, PubMed:14729945). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway (By similarity). In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (PubMed:14729945, PubMed:15178440). Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Production of PtdIns3P by PI3K-C2alpha is required for acquisition of fusion competence in neurosecretion., [RefSeq, PubMed]; There are multiple conformations in equilibrium during the course of PI3K SH3 domain unfolding., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030295 protein kinase activator activity;GO:0043560 insulin receptor substrate binding;GO:0016303 1-phosphatidylinositol-3-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0048471 perinuclear region of cytoplasm;GO:0014704 intercalated disc", "go_biological_process": "GO:0030835 negative regulation of actin filament depolymerization;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0086003 cardiac muscle cell contraction;GO:0001525 angiogenesis;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32871-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06002-1", "uniprot_id": [ { "id": "BFSP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q06002", "type": "external" } ], "mass": 83181.0, "length": 757, "protein_name": "Filensin", "gene_name": "BFSP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "BFSP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Filensin; Beaded filament structural protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "19393038;19875662;28259670;7504675;7588880;8491777", "class_list": "", "function": "Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Involved in altering the calcium regulation of MIP water permeability (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MH65", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0005882 intermediate filament", "go_biological_process": "GO:0045109 intermediate filament organization;GO:0070307 lens fiber cell development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06002-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03968-1", "uniprot_id": [ { "id": "FGF1_BOVIN", "url": "https://www.uniprot.org/uniprot/P03968", "type": "external" } ], "mass": 17493.0, "length": 155, "protein_name": "Fibroblast growth factor 1", "gene_name": "FGF1", "organism": "Bovine", "refseq_name": "fibroblast growth factor 1", "refseq_ac": [ { "id": "NP_001300935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300935", "type": "external" } ], "gene_names_uniprotkb": "FGF1; AFGF; FGFA; HBGF-1", "gene_names_refseq": "ECGF; EDGF II; EDGF; FGF-1; FGF1; FGF2B; HBGF-1; aFGF", "protein_names_uniprotkb": "Fibroblast growth factor 1; Acidic eye-derived growth factor II; Acidic fibroblast growth factor; ECGF; EDGF II; Endothelial cell growth factor; FGF-1; HBGF-1; Heparin-binding growth factor 1; Prostatropin; aFGF", "protein_names_refseq": "acidic eye-derived growth factor II; acidic fibroblast growth factor; endothelial cell growth factor beta and alpha chains; endothelial growth factor; fibroblast growth factor 1 (acidic); fibroblast growth factor 1; fibroblast growth factor 2B; fibroblast growth factor, acidic; heparin-binding growth factor 1; prostatropin", "tax_id": 9913, "disease": "", "pathway": " (bta:281160); (R-BTA-109704); (R-BTA-1257604); (R-BTA-190322); (R-BTA-190370); (R-BTA-190371); (R-BTA-190372); (R-BTA-190373); (R-BTA-190375); (R-BTA-190377); (R-BTA-5654219); (R-BTA-5654221); (R-BTA-5654227); (R-BTA-5654228); (R-BTA-5654687); (R-BTA-5654688); (R-BTA-5654689); (R-BTA-5654693); (R-BTA-5654695); (R-BTA-5654699); (R-BTA-5654700); (R-BTA-5654704); (R-BTA-5654706); (R-BTA-5654710); (R-BTA-5654712); (R-BTA-5654719); (R-BTA-5654720); (R-BTA-5654726); (R-BTA-5654727); (R-BTA-5654732); (R-BTA-5654733); (R-BTA-5673001); (R-BTA-6811558)", "pathway_count": 33, "publication_count": 13, "publication_id_list": "11039909;1280126;16415522;1702556;2425435;2714282;2849564;3205724;3532107;3768327;4065099;4071057;9712834", "class_list": "", "function": "FGF1 and FGF7 may be involved differently in the process of follicle maturation and CL formation, which is strongly dependent on angiogenesis, [RefSeq, PubMed]; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBL8", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0044548 S100 protein binding;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P03968-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62739-1", "uniprot_id": [ { "id": "ACTA_BOVIN", "url": "https://www.uniprot.org/uniprot/P62739", "type": "external" } ], "mass": 42009.0, "length": 377, "protein_name": "Actin, aortic smooth muscle", "gene_name": "ACTA2", "organism": "Bovine", "refseq_name": "actin, aortic smooth muscle", "refseq_ac": [ { "id": "NP_001029674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029674", "type": "external" } ], "gene_names_uniprotkb": "ACTA2; ACTSA; ACTVS", "gene_names_refseq": "ACTA2", "protein_names_uniprotkb": "Actin, aortic smooth muscle; 3.6.4.-; Alpha-actin-2", "protein_names_refseq": "actin, alpha 2, smooth muscle, aorta; actin, aortic smooth muscle; alpha actin 2", "tax_id": 9913, "disease": "", "pathway": " (bta:515610); (R-BTA-445355); (R-BTA-9764561); (R-BTA-9913351); (R-BTA-9958825)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "499690", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P03996;P04108;Q3ZCA0;Q862W5", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0009615 response to virus;GO:0030240 skeletal muscle thin filament assembly;GO:0048741 skeletal muscle fiber development;GO:0090131 mesenchyme migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62739-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62326-1", "uniprot_id": [ { "id": "TYB4_BOVIN", "url": "https://www.uniprot.org/uniprot/P62326", "type": "external" } ], "mass": 5053.0, "length": 44, "protein_name": "Thymosin beta-4", "gene_name": "TMSB4X; TMSB4", "organism": "Bovine", "refseq_name": "thymosin beta-4", "refseq_ac": [ { "id": "NP_001002885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002885", "type": "external" } ], "gene_names_uniprotkb": "TMSB4X; TMSB4; THYB4", "gene_names_refseq": "TMSB4X", "protein_names_uniprotkb": "Thymosin beta-4; Ac-Ser-Asp-Lys-Pro; AcSDKP; N-acetyl-SDKP; Seraspenide; T beta-4", "protein_names_refseq": "thymosin beta 4, X chromosome; thymosin beta-4", "tax_id": 9913, "disease": "", "pathway": " (bta:282386); (R-BTA-114608)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "1551869;16677835;2253778;2261438;2915977;6940133;8269922", "class_list": "", "function": "Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Potent inhibitor of bone marrow derived stem cell differentiation (PubMed:2915977). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (PubMed:2915977)., [UniProtKB, PubMed]; Tbeta4 induces apoptotic-related gene expression in leukemic cells, and results in the inhibition of proliferation and induction of differentiation and apoptosis of leukemic cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2VDY8;P01253;P01254;Q56JV5;Q63576", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding;GO:0140311 protein sequestering activity;GO:0003788 actin monomer sequestering activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0050728 negative regulation of inflammatory response;GO:0090303 positive regulation of wound healing;GO:0030334 regulation of cell migration;GO:0071385 cellular response to glucocorticoid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P62326-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04409-1", "uniprot_id": [ { "id": "KPCA_BOVIN", "url": "https://www.uniprot.org/uniprot/P04409", "type": "external" } ], "mass": 76837.0, "length": 672, "protein_name": "Protein kinase C alpha type", "gene_name": "PRKCA", "organism": "Bovine", "refseq_name": "protein kinase C alpha type", "refseq_ac": [ { "id": "NP_776860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776860", "type": "external" } ], "gene_names_uniprotkb": "PRKCA", "gene_names_refseq": "PKRCA; PRKCA", "protein_names_uniprotkb": "Protein kinase C alpha type; 2.7.11.13; PKC-A; PKC-alpha", "protein_names_refseq": "PKC-A; PKC-alpha; protein kinase C alpha type", "tax_id": 9913, "disease": "", "pathway": " (bta:282001)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "24708997;24859649;29608914;30387146;3045562;31960444;3755547;8349635;9013603", "class_list": "", "function": "AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production., [RefSeq, PubMed]; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation. In cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Depending on the cell type, exhibits anti-apoptotic function and protects cells from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, or mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (By similarity). Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Endoplasmic reticulum distribution during bovine oocyte activation is regulated by protein kinase C via actin filaments., [RefSeq, PubMed]; Mechanical stress induced biphasic and directional PKCalpha translocation, [RefSeq, PubMed]; Significant changes in thin filament Ca2+-sensitivity, structure and kinetics are brought about through PKC phosphorylation of cardiac troponin T., [RefSeq, PubMed]; The results of this study indicate the involvement of PKCalpha in the Ca (2+) signaling pathway in response to mechanical stress in endothelial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0030165 PDZ domain binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0045785 positive regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P04409-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04896-1", "uniprot_id": [ { "id": "GNAS2_BOVIN", "url": "https://www.uniprot.org/uniprot/P04896", "type": "external" } ], "mass": 45709.0, "length": 394, "protein_name": "Guanine nucleotide-binding protein G(s) subunit alpha isoforms short", "gene_name": "GNAS", "organism": "Bovine", "refseq_name": "SCG6 (secretogranin VI) isoform SCG6 precursor", "refseq_ac": [ { "id": "NP_001258700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258700", "type": "external" } ], "gene_names_uniprotkb": "GNAS; GNAS1", "gene_names_refseq": "GNAS1; GNAS; NESP55; SCG6", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; 3.6.5.-; Adenylate cyclase-stimulating G alpha protein", "protein_names_refseq": "SCG6 (secretogranin VI) isoform SCG6 precursor; adenylate cyclase-stimulating G alpha protein; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; neuroendocrine secretory protein 55; secretogranin VI; stimulatory G-protein alpha subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:281793)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10427002;11087399;12574119;15591060;16766715;19243146;2022671;21214909;21772288;21956331;3015900;3080331;3081893;32818430;9395396;9417641", "class_list": "", "function": "Application of peptide amide hydrogen-deuterium exchange mass spectrometry to probe changes in the structure of the heterotrimeric bovine G protein, Gs on formation of a complex with agonist-bound human beta(2) adrenergic receptor Publication Status: Online-Only, [RefSeq, PubMed]; Crystal structure of the active state ternary complex composed of agonist-occupied monomeric beta2 adrenergic receptor and nucleotide-free Gs heterotrimer Publication Status: Online-Only, [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (Probable) (PubMed:11087399, PubMed:2022671, PubMed:9395396). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (Probable) (PubMed:11087399, PubMed:2022671, PubMed:9395396). Signaling by an activated GPCR promotes GDP release and GTP binding (Probable) (PubMed:11087399, PubMed:2022671, PubMed:9395396). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (Probable) (PubMed:11087399, PubMed:2022671, PubMed:9395396). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (Probable) (PubMed:11087399, PubMed:2022671, PubMed:9395396). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (Probable) (PubMed:11087399, PubMed:2022671, PubMed:9395396). Functions downstream of beta-adrenergic receptors (By similarity). Stimulates the Ras signaling pathway via RAPGEF2 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound beta1-Adrenergic Receptor., [RefSeq, PubMed]; The results presented here indicate an important role for the imprinted GNAS cluster in underlying complex Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0II85;Q3SZE7", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0005159 insulin-like growth factor receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P04896-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04985-1", "uniprot_id": [ { "id": "ELN_BOVIN", "url": "https://www.uniprot.org/uniprot/P04985", "type": "external" } ], "mass": 64229.0, "length": 747, "protein_name": "Elastin", "gene_name": "ELN", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ELN", "gene_names_refseq": "", "protein_names_uniprotkb": "Elastin; Tropoelastin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "11723132;1632791;16478991;2031719;2543440;26601954;2992576;3032943;3665402;6150137", "class_list": "", "function": "Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04986;P04987;Q28096;Q28097;Q28098;Q28099;Q28101;Q29421", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0071953 elastic fiber", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P04985-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05059-1", "uniprot_id": [ { "id": "CMGA_BOVIN", "url": "https://www.uniprot.org/uniprot/P05059", "type": "external" } ], "mass": 50015.0, "length": 449, "protein_name": "Chromogranin-A", "gene_name": "CHGA", "organism": "Bovine", "refseq_name": "chromogranin-A precursor", "refseq_ac": [ { "id": "NP_851348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851348", "type": "external" } ], "gene_names_uniprotkb": "CHGA", "gene_names_refseq": "CHGA", "protein_names_uniprotkb": "Chromogranin-A; CgA; Pituitary secretory protein I; SP-I", "protein_names_refseq": "SP-I; cgA; chromogranin A (parathyroid secretory protein 1); chromogranin-A precursor; pituitary secretory protein I", "tax_id": 9913, "disease": "", "pathway": " (bta:281070)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "10527498;10753865;10781584;11451958;11584008;12795588;14759560;15723172;16140299;1710890;1779968;18469147;18500827;1986917;1996343;21436258;2387861;25810338;2756155;3018587;3474638;3755681;7535395;7646465;8240272;8243650;8910482;9074643;9115255;9294131;9786174;9809795", "class_list": "", "function": "Cateslytin adopts a dominant beta-sheet character upon interaction with negatively charged membranes, whereas it is essentially unstructured in water as are most short linear antimicrobial peptides., [RefSeq, PubMed]; Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart., [RefSeq, PubMed]; Completely inhibits catecholamine release from chromaffin cells., [UniProtKB, PubMed]; Determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2+) homeostasis in secretory cells, [RefSeq, PubMed]; Has antibacterial activity against Gram-positive bacteria M.luteus, B.megaterium. Not active against Gram-positive bacteria B.cereus, B.subtilis, S.pyogenes, M.fortuitum, S.aureus and L.monocytogenes and against Gram-negative bacteria E.coli, E.cloacae, S.typhimurium, K.pneumoniae and P.aeruginosa. Possesses antifungal activity against N.crassa, A.fumigatus, A.brassicicola, N.hematococca, F.culmorum and F.oxyporum and against the yeast S.cerevisiae and C.albicans. Inactive against A.benhamiae., [UniProtKB, PubMed]; Has antibacterial activity against M.luteus. Not active against E.coli., [UniProtKB, PubMed]; Has antifungal activity against N.crassa, A.fumigatus, A.brassicicola, N.hematococca, F.culmorum, F.oxyporum, A.benhamiae, C.neoformans, as well as against yeasts C.albicans, and C.tropicalis. Seems to be inactive against C.glabrata. Interacts with the fungal cell wall, crosses the plasma membrane and accumulates in fungal cells where it inhibits calcineurin activity., [UniProtKB, PubMed]; Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:9294131, PubMed:9786174). Displays antibacterial activity against Gram-positive bacteria M.luteus and B.megaterium, and Gram-negative bacteria E.coli, and antifungal activity against a variety of filamentous fungi including A.fumigatus, N.hematococca, F.culmorum, F.oxyporum, T.mentagrophytes and several forms of Candida: C.albicans, C.tropicalis, C.glabrata and C.neoform (PubMed:15723172). Can induce mast cell migration, degranulation and production of cytokines and chemokines (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (PubMed:21436258)., [UniProtKB, PubMed]; Strongly inhibits glucose induced insulin release from the pancreas., [UniProtKB, PubMed]; Vasoconstriction-Inhibiting Factor (VIF), a degradation product of chromogranin A, is a vasoregulatory peptide that modulates the vasoconstrictive effects of angiotensin II by acting on the angiotensin II type 2 receptor., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P79392;Q2KJ52", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030133 transport vesicle", "go_biological_process": "GO:0030155 regulation of cell adhesion;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0046888 negative regulation of hormone secretion", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "P05059-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06624-1", "uniprot_id": [ { "id": "MIP_BOVIN", "url": "https://www.uniprot.org/uniprot/P06624", "type": "external" } ], "mass": 28223.0, "length": 263, "protein_name": "Lens fiber major intrinsic protein", "gene_name": "MIP", "organism": "Bovine", "refseq_name": "lens fiber major intrinsic protein", "refseq_ac": [ { "id": "NP_776362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776362", "type": "external" } ], "gene_names_uniprotkb": "MIP", "gene_names_refseq": "AQP0; MIP; MP22; MP26", "protein_names_uniprotkb": "Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26", "protein_names_refseq": "MIP26; aquaporin-0; lens fiber major intrinsic protein", "tax_id": 9913, "disease": "", "pathway": " (bta:280859); (R-BTA-432047)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "15377788;16309700;19883592;19961829;2176601;23893133;2415383;25044119;27378310;28259670;30790544;3882455;6207938;9375569", "class_list": "", "function": "AQP-0 and connexins can be segregated in the membrane by protein-lipid interactions as modified by AQP-0 homo-oligomerization, [RefSeq, PubMed]; Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:23893133, PubMed:30790544). Specifically expressed in lens fiber cells, this aquaporin is crucial for maintaining lens water homeostasis and transparency. Beyond water permeability, it also acts as a cell-to-cell adhesion molecule, forming thin junctions between lens fiber cells that are essential for maintaining the ordered structure and transparency of the lens (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Determined the pseudoatomic structure of full-length aquaporin-0 (AQP0) in complex with calmodulin, using electron microscopy to elucidate how this signaling protein modulates water-channel function., [RefSeq, PubMed]; In the presence of alpha-crystallin, this conversion to beta-sheet is minimized, suggesting that the protein structure that binds to the molecular chaperone is mostly the alpha-helical structure of AQP0., [RefSeq, PubMed]; The data evidence a broad lipidation profile of AQP0 that is both species and site independent, suggesting a chemical-based ester aminolysis mechanism to explain such modifications., [RefSeq, PubMed]; Tyr23 is a dominate factor leading to the low water permeability in AQP0., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0015250 water channel activity;GO:0005212 structural constituent of eye lens;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0006833 water transport;GO:0036438 maintenance of lens transparency", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P06624-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07507-1", "uniprot_id": [ { "id": "MGP_BOVIN", "url": "https://www.uniprot.org/uniprot/P07507", "type": "external" } ], "mass": 12217.0, "length": 103, "protein_name": "Matrix Gla protein", "gene_name": "MGP", "organism": "Bovine", "refseq_name": "matrix Gla protein precursor", "refseq_ac": [ { "id": "NP_777132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777132", "type": "external" } ], "gene_names_uniprotkb": "MGP", "gene_names_refseq": "MGP", "protein_names_uniprotkb": "Matrix Gla protein; MGP", "protein_names_refseq": "matrix Gla protein precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:282660)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12658628;14587031;15456771;15982861;1939157;19661459;21161195;3387234;3877721;8061611", "class_list": "", "function": "Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation., [UniProtKB]; Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein., [RefSeq, PubMed]; MGP has a novel binding activity for vitronectin, [RefSeq, PubMed]; MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF expression, [RefSeq, PubMed]; Selective CaSR activation, either by extracellular calcium or AMG 641, increased MGP expression in vivo in the arterial wall and in vitro in bovine vascular smooth muscle cells., [RefSeq, PubMed]; The effect of MGP on calcification and osteogenic differentiation is determined by availability of BMP-2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q54A30", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030154 cell differentiation;GO:0001503 ossification;GO:0030500 regulation of bone mineralization;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P07507-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07514-1", "uniprot_id": [ { "id": "NB5R3_BOVIN", "url": "https://www.uniprot.org/uniprot/P07514", "type": "external" } ], "mass": 34122.0, "length": 301, "protein_name": "NADH-cytochrome b5 reductase 3", "gene_name": "CYB5R3", "organism": "Bovine", "refseq_name": "NADH-cytochrome b5 reductase 3", "refseq_ac": [ { "id": "NP_001096720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096720", "type": "external" } ], "gene_names_uniprotkb": "CYB5R3; DIA1", "gene_names_refseq": "CYB5R3", "protein_names_uniprotkb": "NADH-cytochrome b5 reductase 3; 1.6.2.2; B5R; Cytochrome b5 reductase; Diaphorase-1", "protein_names_refseq": "B5R; NADH-cytochrome b5 reductase 3; diaphorase-1", "tax_id": 9913, "disease": "", "pathway": " (bta:515773); (R-BTA-196836); (R-BTA-211945); (R-BTA-6798695)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1370824;3654589;3900065;6436247;6643503", "class_list": "", "function": "Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H7G0", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0071949 FAD binding;GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0090524 cytochrome-b5 reductase activity, acting on NADH;GO:0050421 nitrite reductase (NO-forming) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005811 lipid droplet;GO:1903958 nitric-oxide synthase complex", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0006809 nitric oxide biosynthetic process;GO:0016126 sterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07514-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07589-1", "uniprot_id": [ { "id": "FINC_BOVIN", "url": "https://www.uniprot.org/uniprot/P07589", "type": "external" } ], "mass": 272154.0, "length": 2478, "protein_name": "Fibronectin", "gene_name": "FN1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FN1", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibronectin; FN", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "19674964;25128524;3780752;6218503;6304699", "class_list": "", "function": "Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling., [UniProtKB, UniProtKB]; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 8, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0043394 proteoglycan binding;GO:0097718 disordered domain specific binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007044 cell-substrate junction assembly;GO:0001525 angiogenesis;GO:0007399 nervous system development;GO:0007507 heart development;GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P07589-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08037-1", "uniprot_id": [ { "id": "B4GT1_BOVIN", "url": "https://www.uniprot.org/uniprot/P08037", "type": "external" } ], "mass": 44843.0, "length": 402, "protein_name": "Beta-1,4-galactosyltransferase 1", "gene_name": "B4GALT1", "organism": "Bovine", "refseq_name": "beta-1,4-galactosyltransferase 1", "refseq_ac": [ { "id": "NP_803478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803478", "type": "external" } ], "gene_names_uniprotkb": "B4GALT1; GALT; GGTB2", "gene_names_refseq": "B4GALT1; GGTB2", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 1; 2.4.1.-; 2.4.1.22; 2.4.1.275; 2.4.1.38; 2.4.1.90; Beta-1,4-GalTase 1; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; Beta4Gal-T1; Lactose synthase A protein; N-acetyllactosamine synthase; Nal synthase; Neolactotriaosylceramide beta-1,4-galactosyltransferase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1; b4Gal-T1", "protein_names_refseq": "N-acetyllactosamine synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1; b4Gal-T1; beta-1,4-GalTase 1; beta-1,4-galactosyltransferase 1; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; beta-galactosyltransferase 2 (glycoprotein); beta4Gal-T1; glycoprotein-4-beta-galactosyltransferase 2; lactose synthase A protein; nal synthase; neolactotriaosylceramide beta-1,4-galactosyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:281781); (R-BTA-2022854); (R-BTA-2534343); (R-BTA-5653890); (R-BTA-6798695); (R-BTA-975577)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "10393171;11419947;12051854;12927542;1898734;2105947;2117606;22311019;2419911;2502398;2503823;25462875;3014508;35872821;9405390", "class_list": "glycogene;glycosyltransferase", "function": "Galactosyltransferase acting in the Golgi stacks. Catalyzes the transfer of galactose (Gal) from UDP-alpha-D-galactose in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type N-linked glycans (By similarity) (PubMed:9405390). Adds one Gal residue to both GlcNAc beta(1->2)-linked to the alpha(1->3) and alpha(1->6) mannose antennae of complex-type N-glycans, enabling the formation of mono- and di-galactosylated glycoforms (By similarity). Galactosylates complex-type N-glycans attached on the fragment crystallizable (Fc) of immunoglobulin-gamma isotypes (IgGs), a prerequisite for antibody glycan sialylation and related anti-inflammatory effector functions. Can also transfer a Gal residue to free GlcNAc to form N-acetyllactosamine (By similarity). With LALBA/alpha-lactalbumin forms the lactose synthase complex responsible for production of large amounts of lactose in the lactating mammary gland. Interaction with LALBA alters the sugar substrate specificity of the catalytic domain, enabling high affinity binding of glucose and its transformation to lactose (By similarity) (PubMed:12927542)., [UniProtKB, PubMed, PubMed, UniProtKB]; Hypothesized that engineering B4GALT1 to block cleavage and secretion would enhance its retention and its function; to test this hypothesis, replaced CTS domains of bovine B4GALT1 with those from human FUT7, which is not cleaved and secreted., [RefSeq, PubMed]; The beta4galt1 gene is potentially associated with milk production traits in dairy cows and should be considered for further studies on genetics of the milk production traits., [RefSeq, PubMed]; The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, like those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. Acts as a sperm receptor for ZP3 O-linked glycans on the zona pellucida leading to activation of G protein signaling and acrosome reaction., [UniProtKB, UniProtKB]; The secreted form is proficient in galactosyltransferase activity and could be involved in glycan remodeling in biological fluids., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VC05;Q8MIG0", "ec_number_list": [ { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0016323 basolateral plasma membrane;GO:0009897 external side of plasma membrane;GO:0030175 filopodium", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006487 protein N-linked glycosylation;GO:0009312 oligosaccharide biosynthetic process;GO:0005989 lactose biosynthetic process;GO:1901137 carbohydrate derivative biosynthetic process", "synthesized_glycan_count": 10444, "hit_score": 1.7, "record_id": "P08037-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08057-1", "uniprot_id": [ { "id": "TNNI3_BOVIN", "url": "https://www.uniprot.org/uniprot/P08057", "type": "external" } ], "mass": 24054.0, "length": 212, "protein_name": "Troponin I, cardiac muscle", "gene_name": "TNNI3", "organism": "Bovine", "refseq_name": "troponin I, cardiac muscle", "refseq_ac": [ { "id": "NP_001035607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035607", "type": "external" } ], "gene_names_uniprotkb": "TNNI3", "gene_names_refseq": "TNNI3", "protein_names_uniprotkb": "Troponin I, cardiac muscle; Cardiac troponin I", "protein_names_refseq": "cardiac troponin I; troponin I, cardiac muscle-like; troponin I, cardiac muscle", "tax_id": 9913, "disease": "", "pathway": " (bta:511094)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19496907;22489623;2373082;2967699;3042023", "class_list": "", "function": "An Ala8Val mutation enhances the effect of cardiac troponin I pseudophosphorylation on the rate of dissociation of calcium from reconstituted thin filaments., [RefSeq, PubMed]; Serum cardiac troponin I cannot be used to distinguish cattle with pericarditis from cattle with other primary cardiac diseases or noncardiac, intrathoracic disorders., [RefSeq, PubMed]; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZG22", "ec_number_list": [], "go_molecular_function": "GO:0030172 troponin C binding;GO:0000287 magnesium ion binding;GO:0003779 actin binding;GO:0005524 ATP binding;GO:0042030 ATPase inhibitor activity", "go_cellular_component": "GO:1990584 cardiac Troponin complex;GO:0097512 cardiac myofibril;GO:0005861 troponin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0060048 cardiac muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P08057-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08487-1", "uniprot_id": [ { "id": "PLCG1_BOVIN", "url": "https://www.uniprot.org/uniprot/P08487", "type": "external" } ], "mass": 148313.0, "length": 1291, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "gene_name": "PLCG1", "organism": "Bovine", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "refseq_ac": [ { "id": "NP_776850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776850", "type": "external" } ], "gene_names_uniprotkb": "PLCG1", "gene_names_refseq": "PLCG1", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 3.1.4.11; PLC-148; PLC-II; PLC-gamma-1; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; Phospholipase C-gamma-1", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; PLC-II; PLC-gamma-1; phosphoinositide phospholipase C-gamma-1; phosphoinositide phospholipase C; phospholipase C-II", "tax_id": 9913, "disease": "", "pathway": " (bta:281987)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1689310;1689311;1708307;17116690;2173144;2831461;8181064;8631863;9281317", "class_list": "", "function": "Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (By similarity). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PLC-gamma1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal Src homology (SH2C) domain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0120548 phosphatidylinositol phospholipase C activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0032587 ruffle membrane;GO:0001726 ruffle", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0009395 phospholipid catabolic process;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P08487-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09867-1", "uniprot_id": [ { "id": "ROA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P09867", "type": "external" } ], "mass": 34196.0, "length": 320, "protein_name": "Heterogeneous nuclear ribonucleoprotein A1", "gene_name": "HNRNPA1", "organism": "Bovine", "refseq_name": "heterogeneous nuclear ribonucleoprotein A1", "refseq_ac": [ { "id": "NP_001039376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039376", "type": "external" } ], "gene_names_uniprotkb": "HNRNPA1; HNRPA1", "gene_names_refseq": "HNRNPA1; HNRPA1; hnRNP A1", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein A1; Helix-destabilizing protein; Single-strand RNA-binding protein; UP1; Unwinding protein 1; hnRNP A1; hnRNP core protein A1", "protein_names_refseq": "UP1; helix-destabilizing protein; heterogeneous nuclear ribonucleoprotein A1; hnRNP core protein A1; single-strand RNA-binding protein; unwinding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:505093); (R-BTA-6803529); (R-BTA-72163); (R-BTA-72203); (R-BTA-9770562)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "2994041;3032834;3941105", "class_list": "", "function": "Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KJC4", "ec_number_list": [], "go_molecular_function": "GO:0035198 miRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0051028 mRNA transport;GO:1903936 cellular response to sodium arsenite", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P09867-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C0S9-1", "uniprot_id": [ { "id": "H2A1_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C0S9", "type": "external" } ], "mass": 14091.0, "length": 130, "protein_name": "Histone H2A type 1", "gene_name": "", "organism": "Bovine", "refseq_name": "H2A clustered histone 14", "refseq_ac": [ { "id": "NP_001092190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092190", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "H2AC14; HIST1H2AG", "protein_names_uniprotkb": "Histone H2A type 1; H2A.1b", "protein_names_refseq": "H2A clustered histone 14; histone cluster 1, H2ag", "tax_id": 9913, "disease": "", "pathway": " (bta:104968446); (bta:104975683); (bta:529277); (bta:616611); (bta:616790); (bta:618824); (R-BTA-3214815); (R-BTA-3214847); (R-BTA-3214858); (R-BTA-5689603); (R-BTA-5689880); (R-BTA-5689901)", "pathway_count": 12, "publication_count": 8, "publication_id_list": "1010839;1999173;265581;2713375;4555425;4568599;4667695;4856314", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJH1;P02261", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P0C0S9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CG53-1", "uniprot_id": [ { "id": "UBB_BOVIN", "url": "https://www.uniprot.org/uniprot/P0CG53", "type": "external" } ], "mass": 34308.0, "length": 305, "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "organism": "Bovine", "refseq_name": "polyubiquitin-B", "refseq_ac": [ { "id": "NP_776558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776558", "type": "external" } ], "gene_names_uniprotkb": "UBB", "gene_names_refseq": "UBB", "protein_names_uniprotkb": "Polyubiquitin-B", "protein_names_refseq": "polyubiquitin-B; polyubiquitin", "tax_id": 9913, "disease": "", "pathway": " (bta:281370); (R-BTA-110312); (R-BTA-110314); (R-BTA-110320); (R-BTA-1169091); (R-BTA-1234176); (R-BTA-1253288); (R-BTA-1295596); (R-BTA-1358803); (R-BTA-156827); (R-BTA-168638); (R-BTA-174048); (R-BTA-174084); (R-BTA-174113); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-179409); (R-BTA-1799339); (R-BTA-182971); (R-BTA-187577); (R-BTA-195253); (R-BTA-201681); (R-BTA-202424); (R-BTA-205043); (R-BTA-209543); (R-BTA-209560); (R-BTA-2122948); (R-BTA-2173788); (R-BTA-2173791); (R-BTA-2173795); (R-BTA-2173796); (R-BTA-2467813); (R-BTA-2559582); (R-BTA-2672351); (R-BTA-2871837); (R-BTA-3134975); (R-BTA-349425); (R-BTA-3769402); (R-BTA-382556); (R-BTA-445989); (R-BTA-450302); (R-BTA-450321); (R-BTA-450408); (R-BTA-4608870); (R-BTA-4641257); (R-BTA-4641258); (R-BTA-4641263); (R-BTA-5205685); (R-BTA-532668); (R-BTA-5357905); (R-BTA-5357956); (R-BTA-5358346); (R-BTA-5607761); (R-BTA-5607764); (R-BTA-5610780); (R-BTA-5610785); (R-BTA-5632684); (R-BTA-5654726); (R-BTA-5654727); (R-BTA-5654732); (R-BTA-5654733); (R-BTA-5655862); (R-BTA-5656121); (R-BTA-5656169); (R-BTA-5668541); (R-BTA-5675221); (R-BTA-5675482); (R-BTA-5676590); (R-BTA-5684264); (R-BTA-5685942); (R-BTA-5687128); (R-BTA-5689603); (R-BTA-5689877); (R-BTA-5689880); (R-BTA-5689896); (R-BTA-5689901); (R-BTA-5693537); (R-BTA-5693565); (R-BTA-5693607); (R-BTA-5696394); (R-BTA-5696395); (R-BTA-5696397); (R-BTA-5696400); (R-BTA-6781823); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-6783310); (R-BTA-6791226); (R-BTA-6804756); (R-BTA-6804757); (R-BTA-6804760); (R-BTA-6807004); (R-BTA-68867); (R-BTA-68949); (R-BTA-69017); (R-BTA-69231); (R-BTA-69481); (R-BTA-69601); (R-BTA-72649); (R-BTA-72689); (R-BTA-72695); (R-BTA-72702); (R-BTA-72706); (R-BTA-75815); (R-BTA-8849469); (R-BTA-8852276); (R-BTA-8854050); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-8863795); (R-BTA-8866427); (R-BTA-8866652); (R-BTA-8866654); (R-BTA-8939236); (R-BTA-8939902); (R-BTA-8941858); (R-BTA-8948747); (R-BTA-8948751); (R-BTA-8951664); (R-BTA-901032); (R-BTA-9010553); (R-BTA-9020702); (R-BTA-9033241); (R-BTA-909733); (R-BTA-912631); (R-BTA-917729); (R-BTA-917937); (R-BTA-936440); (R-BTA-936964); (R-BTA-937039); (R-BTA-937041); (R-BTA-937042); (R-BTA-937072); (R-BTA-9645460); (R-BTA-9646399); (R-BTA-9648002); (R-BTA-9664873); (R-BTA-9705462); (R-BTA-9706369); (R-BTA-9708530); (R-BTA-975144); (R-BTA-975163); (R-BTA-9755511); (R-BTA-9758274); (R-BTA-975956); (R-BTA-975957); (R-BTA-9762114); (R-BTA-9766229); (R-BTA-9770562); (R-BTA-9824878); (R-BTA-983168); (R-BTA-9861718); (R-BTA-9929356); (R-BTA-9929491); (R-BTA-9931269); (R-BTA-9931295); (R-BTA-9932298); (R-BTA-9954709); (R-BTA-9954714); (R-BTA-9954716); (R-BTA-9958810)", "pathway_count": 162, "publication_count": 8, "publication_id_list": "1170880;12658628;1333954;1846490;26116755;28924046;6254502;8382528", "class_list": "", "function": "Data suggest ordered binding of UBCH7-ubiquitin to E6AP Site 1 (for E6AP-Cys820/ubiquitin thioester formation) and E6AP Site 2 (for subsequent chain elongation); proximal indexation accounts for radially symmetric structure of E6AP, requirement for oligomerization in polyubiquitin chain formation, and mechanistic rationale for Cys820-ubiquitin thioester as platform in chain assembly. (E6AP = ubiquitin-protein ligase E6AP), [RefSeq, PubMed]; Exists either covalently attached to another protein, or free (unanchored) (By similarity). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains) (PubMed:26116755). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B (By similarity). Linear polymer chains formed via attachment by the initiator Met lead to cell signaling (By similarity). Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed (By similarity). When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97577;P02248;P02249;P02250;P62990;P80169;Q01235;Q24K23;Q28169;Q28170;Q29120;Q3T0V5;Q3ZCE3;Q862C1;Q862F4;Q862M4;Q862T5;Q862X8;Q91887;Q91888", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005741 mitochondrial outer membrane;GO:0043025 neuronal cell body;GO:0043005 neuron projection;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0019941 modification-dependent protein catabolic process;GO:1902527 positive regulation of protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P0CG53-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10152-1", "uniprot_id": [ { "id": "ANG1_BOVIN", "url": "https://www.uniprot.org/uniprot/P10152", "type": "external" } ], "mass": 16970.0, "length": 148, "protein_name": "Angiogenin-1", "gene_name": "ANG1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ANG1; ANG", "gene_names_refseq": "", "protein_names_uniprotkb": "Angiogenin-1; 3.1.27.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "2775757;3064806;3197838;7708754;8688423", "class_list": "", "function": "Secreted ribonuclease that can either promote or restrict cell proliferation of target cells, depending on the context. Endocytosed in target cells via its receptor PLXNB2 and translocates to the cytoplasm or nucleus. Under stress conditions, localizes to the cytoplasm and promotes the assembly of stress granules (SGs): specifically cleaves a subset of tRNAs within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs), resulting in translation repression and inhibition of cell proliferation (By similarity). tiRNas also prevent formation of apoptosome, thereby promoting cell survival (By similarity). Preferentially cleaves RNAs between a pyrimidine and an adenosine residue, suggesting that it cleaves the anticodon loop of tRNA(Ala) (32-UUAGCAU-38) after positions 33 and 36. Cleaves a subset of tRNAs, including tRNA(Ala), tRNA(Glu), tRNA(Gly), tRNA(Lys), tRNA(Val), tRNA(His), tRNA(Asp) and tRNA(Sec). Under growth conditions and in differentiated cells, translocates to the nucleus and stimulates ribosomal RNA (rRNA) transcription, including that containing the initiation site sequences of 45S rRNA, thereby promoting cell growth and proliferation. Angiogenin induces vascularization of normal and malignant tissues via its ability to promote rRNA transcription (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9GKP9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:0001525 angiogenesis;GO:0019731 antibacterial humoral response;GO:0030154 cell differentiation;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P10152-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10175-1", "uniprot_id": [ { "id": "COX8B_BOVIN", "url": "https://www.uniprot.org/uniprot/P10175", "type": "external" } ], "mass": 7639.0, "length": 70, "protein_name": "Cytochrome c oxidase subunit 8B, mitochondrial", "gene_name": "COX8B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COX8B; COX8H", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 8B, mitochondrial; Cytochrome c oxidase polypeptide VIII-heart; Cytochrome c oxidase subunit 8-1; Cytochrome c oxidase subunit 8H; IX; VIIIb", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:615757)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10089392;10771420;1689292;20385840;2176624;26698328;27605664;31533957;6327490;7766994;8638158", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KI98", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P10175-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10731-1", "uniprot_id": [ { "id": "AMD_BOVIN", "url": "https://www.uniprot.org/uniprot/P10731", "type": "external" } ], "mass": 108177.0, "length": 972, "protein_name": "Peptidyl-glycine alpha-amidating monooxygenase", "gene_name": "PAM", "organism": "Bovine", "refseq_name": "peptidyl-glycine alpha-amidating monooxygenase precursor", "refseq_ac": [ { "id": "NP_776373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776373", "type": "external" } ], "gene_names_uniprotkb": "PAM", "gene_names_refseq": "PAM", "protein_names_uniprotkb": "Peptidyl-glycine alpha-amidating monooxygenase; PAL; PAM; Peptidylamidoglycolate lyase", "protein_names_refseq": "peptidyl-glycine alpha-amidating monooxygenase precursor; peptidyl-glycine alpha-amidating monooxygenase", "tax_id": 9913, "disease": "", "pathway": " (bta:280890)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2059626;23971190;3153462", "class_list": "", "function": "Bifunctional enzyme that catalyzes amidation of the C-terminus of proteins (By similarity). Alpha-amidation is present at the C-terminus of many endocrine hormones and neuropeptides and is required for their activity (PubMed:2059626). C-terminal amidation also takes place in response to protein fragmentation triggered by oxidative stress, promoting degradation of amidated protein fragments by the proteasome (By similarity). Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme (By similarity). The first step, catalyzed by peptidyl alpha-hydroxylating monooxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S stereochemistry) at the alpha-carbon (C-alpha) of the C-terminal glycine of the peptidylglycine substrate (By similarity). The second step, catalyzed by the peptidylglycine amidoglycolate lyase (PAL) domain, is the zinc-dependent cleavage of the N-C-alpha bond, producing the alpha-amidated peptide and glyoxylate (PubMed:2059626). Similarly, catalyzes the two-step conversion of an N-fatty acylglycine to a primary fatty acid amide and glyoxylate (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; These data suggest that cortisol affects oxytocin synthesis and secretion in bovine ovarian cells, by acting on the expression of key genes, that may impair ovary, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.17.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.17.3", "type": "external" }, { "id": "4.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.5", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0004504 peptidylglycine monooxygenase activity;GO:0004598 peptidylamidoglycolate lyase activity;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0030658 transport vesicle membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0001519 peptide amidation;GO:0062112 fatty acid primary amide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P10731-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10897-1", "uniprot_id": [ { "id": "CY561_BOVIN", "url": "https://www.uniprot.org/uniprot/P10897", "type": "external" } ], "mass": 27904.0, "length": 252, "protein_name": "Transmembrane ascorbate-dependent reductase CYB561", "gene_name": "CYB561", "organism": "Bovine", "refseq_name": "transmembrane ascorbate-dependent reductase CYB561", "refseq_ac": [ { "id": "NP_777262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777262", "type": "external" } ], "gene_names_uniprotkb": "CYB561", "gene_names_refseq": "CYB561", "protein_names_uniprotkb": "Transmembrane ascorbate-dependent reductase CYB561; 7.2.1.3; Chromomembrin B; Cytochrome b-561; Cytochrome b561", "protein_names_refseq": "chromomembrin B; cytochrome b-561; transmembrane ascorbate-dependent reductase CYB561", "tax_id": 9913, "disease": "", "pathway": " (bta:317663)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12438163;12653566;12768340;1623014;16428304;17602662;18501187;21401125;2460342;3597367;7465055;9287327", "class_list": "", "function": "A detailed characterization of cyt b561 using electron paramagnetic resonance (EPR) and optical spectroscopy on the wild-type and mutant forms of the cytochrome expressed in insect cells, [RefSeq, PubMed]; Amino-terminal peptide showed that the initial Met residue was acetylated but there was no other posttranslational modification in the amino-terminal region, [RefSeq, PubMed]; Cyb561 from chromaffin cell membranes has high and low potential hemes as demonstrated by electron paramagnetic resonance and circular dichroism., [RefSeq, PubMed]; Importance of the two well-conserved Cys residues near the intravesicular heme center, [RefSeq, PubMed]; The functional and structural roles of the EM3 residues and several adjacent residues (residues 70-85) in the bovine cytochrome, [RefSeq, PubMed]; The pH-induced alteration and the destruction of heme in cytochrome b561 under oxidative conditions may play a significant role in the amplification of oxidative stress in catecholaminergic neurons., [RefSeq, PubMed]; These results indicate that His92 can be considered part of the b(H) heme center, and His110 part of the b(L) heme center, in adrenal cyt b(561)., [RefSeq, PubMed]; Transmembrane reductase that probably uses ascorbate as an electron donor to reduce Fe(3+) into Fe(2+) and could play a role in iron transport (By similarity). It is also able to reduce extracellular monodehydro-L-ascorbate and could be involved in the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes (PubMed:1623014, PubMed:18501187, PubMed:3597367)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5F5", "ec_number_list": [ { "id": "7.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0140575 transmembrane monodehydroascorbate reductase activity;GO:0140571 transmembrane ascorbate ferrireductase activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0042584 chromaffin granule membrane", "go_biological_process": "GO:0140576 ascorbate homeostasis;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P10897-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11064-1", "uniprot_id": [ { "id": "PPAC_BOVIN", "url": "https://www.uniprot.org/uniprot/P11064", "type": "external" } ], "mass": 18055.0, "length": 158, "protein_name": "Low molecular weight phosphotyrosine protein phosphatase", "gene_name": "ACP1", "organism": "Bovine", "refseq_name": "low molecular weight phosphotyrosine protein phosphatase", "refseq_ac": [ { "id": "NP_776403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776403", "type": "external" } ], "gene_names_uniprotkb": "ACP1", "gene_names_refseq": "ACP1", "protein_names_uniprotkb": "Low molecular weight phosphotyrosine protein phosphatase; 3.1.3.2; 3.1.3.48; LMW-PTPase; LMW-PTP; Low molecular weight cytosolic acid phosphatase", "protein_names_refseq": "LMW-PTPase; LMW-PTP; acid phosphatase 1, soluble; low molecular weight cytosolic acid phosphatase; low molecular weight phosphotyrosine protein phosphatase; phosphatase 1, soluble; ptpase", "tax_id": 9913, "disease": "", "pathway": " (bta:280977)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1339287;1526287;2644264;8052313;8110762;8132604;8135752;8172896;8319676;8993313", "class_list": "", "function": "Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P11064-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11151-1", "uniprot_id": [ { "id": "LIPL_BOVIN", "url": "https://www.uniprot.org/uniprot/P11151", "type": "external" } ], "mass": 53378.0, "length": 478, "protein_name": "Lipoprotein lipase", "gene_name": "LPL", "organism": "Bovine", "refseq_name": "lipoprotein lipase precursor", "refseq_ac": [ { "id": "NP_001068588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068588", "type": "external" } ], "gene_names_uniprotkb": "LPL", "gene_names_refseq": "LPL", "protein_names_uniprotkb": "Lipoprotein lipase; 3.1.1.32; 3.1.1.34; LPL; Phospholipase A1", "protein_names_refseq": "lipoprotein lipase precursor; phospholipase A1", "tax_id": 9913, "disease": "", "pathway": " (bta:280843); (R-BTA-8963889); (R-BTA-8963901); (R-BTA-975634)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10727238;16179346;2142941;2674142;27845686;27854545;2885834;29899144;30703449;31477272;3536511;9188470;9555944", "class_list": "", "function": "Isothermal titration calorimetry (ITC) can be used for quantitative measurements of LPL activity and interactions under in vivo-like conditions, for comparisons of the properties of plasma samples from patients and control subjects as substrates for LPL, as well as for testing of drug candidates developed with the aim to affect the LPL system., [RefSeq, PubMed]; Key enzyme in triglyceride metabolism (PubMed:10727238, PubMed:16179346, PubMed:9188470). Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:10727238, PubMed:16179346, PubMed:9188470). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (PubMed:9188470)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; MiR-224 regulated the adipogenic differentiation of bovine preadipocytes by targeting LPL., [RefSeq, PubMed]; MiR-29b targets LPL and TDG genes and regulates apoptosis and triglyceride production in mammary epithelial cells., [RefSeq, PubMed]; This report describes a novel mechanism of action for stimulation of LPL activity by apoC-II mimetic peptides., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q17R03", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0034185 apolipoprotein binding;GO:0042803 protein homodimerization activity;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0034361 very-low-density lipoprotein particle;GO:0042627 chylomicron", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:1904179 positive regulation of adipose tissue development;GO:0001523 retinoid metabolic process;GO:0006641 triglyceride metabolic process;GO:0045600 positive regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P11151-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11541-1", "uniprot_id": [ { "id": "PDE6A_BOVIN", "url": "https://www.uniprot.org/uniprot/P11541", "type": "external" } ], "mass": 99341.0, "length": 859, "protein_name": "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha", "gene_name": "PDE6A", "organism": "Bovine", "refseq_name": "rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha", "refseq_ac": [ { "id": "NP_001001526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001526", "type": "external" } ], "gene_names_uniprotkb": "PDE6A; PDEA", "gene_names_refseq": "PDE6A", "protein_names_uniprotkb": "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; 3.1.4.35; GMP-PDE alpha; PDE V-B1", "protein_names_refseq": "GMP-PDE alpha; PDE V-B1; phosphodiesterase 6A, cGMP-specific, rod, alpha; phosphodiesterase, cyclic GMP (rod receptor), alpha polypeptide; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:281973)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12372317;15668239;2155175;25809480;2822478;2826095;31394113;31690623;33007200;38159849", "class_list": "", "function": "A structural basis for interpreting how mutations in rod PDE6 subunits can lead to retinal diseases, is discussed., [RefSeq, PubMed]; Analysis of the Rod PDE6 holoenzyme (subunit composition, alphabetagammagamma) reveals the mechanism of visual excitation, [RefSeq, PubMed]; Catalytic alpha subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PDE6G) (PubMed:33007200, PubMed:38159849). Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification (PubMed:33007200, PubMed:38159849). Decreased cytosolic cGMP levels result in closure of cGMP-gated cation channels at the plasma membrane, leading to rod photoreceptor hyperpolarization (Probable)., [UniProtKB, PubMed, PubMed]; Structural analysis of cGMP phosphodiesterase 6 alpha, beta and gamma interactions, [RefSeq, PubMed]; Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6. Erratum:[Mol Cell. 2021 Jun 3;81(11):2496. doi: 10.1016/j.molcel.2021.05.006. PMID: 34087182], [RefSeq, PubMed]; The approximately 11 A map revealed previously unseen features of PDE6, and each domain was readily fit with high resolution structures. Erratum:[J Biol Chem. 2015 Jul 10;290(28):17131-2. doi: 10.1074/jbc.A115.647636. PMID: 26163476], [RefSeq, PubMed]; The unique Palphabeta heterodimer contributes to the sophisticated regulation in visual transduction through interaction with Pgamma, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0097381 photoreceptor disc membrane;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0060041 retina development in camera-type eye;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P11541-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12763-1", "uniprot_id": [ { "id": "FETUA_BOVIN", "url": "https://www.uniprot.org/uniprot/P12763", "type": "external" } ], "mass": 38419.0, "length": 359, "protein_name": "Alpha-2-HS-glycoprotein", "gene_name": "AHSG", "organism": "Bovine", "refseq_name": "alpha-2-HS-glycoprotein precursor", "refseq_ac": [ { "id": "NP_776409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776409", "type": "external" } ], "gene_names_uniprotkb": "AHSG; FETUA", "gene_names_refseq": "AHSG", "protein_names_uniprotkb": "Alpha-2-HS-glycoprotein; Asialofetuin; Fetuin-A", "protein_names_refseq": "alpha-2-HS-glycoprotein precursor; asialofetuin; fetuin-A", "tax_id": 9913, "disease": "", "pathway": " (bta:280988); (R-BTA-114608); (R-BTA-381426); (R-BTA-6798695); (R-BTA-8957275)", "pathway_count": 5, "publication_count": 39, "publication_id_list": "11801660;1372525;1380674;15240697;15253437;16075062;16393994;1689725;1691598;19358553;19674964;21156141;23345538;23662732;24279413;2436943;2445744;2447075;2461366;2477056;2477057;24907489;25456591;29016670;29966421;30573663;33889819;37217939;4137945;6165360;7513972;7527189;7690196;8053566;8119729;83994;8606061;8746565;9266717", "class_list": "", "function": "Comparing the proteoform profile and post-translational modifications of human and bovine serum fetuin, we observe that, although the gene structures of these two proteins are alike, they represent quite distinct proteins when their glycoproteoform profile is also taken into consideration, [RefSeq, PubMed]; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone., [UniProtKB]; Site-specific analysis of the O-glycosylation of bovine fetuin by electron-transfer dissociation mass spectrometry., [RefSeq, PubMed]; These experiments revealed a second mechanism of long-term mineral ion stabilization by the fetuin-A that is complementary to the formation of calciprotein particles., [RefSeq, PubMed]; Two glycoproteins, AHSG and HPX, represent a pivotal glycoprotein of the cytoprotective activity for WN1316, showing a concrete evidence for the novel glycan-independent function of serum glycoproteins in neuroprotective drug efficacy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 6, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 38, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 70, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A6QLF7", "ec_number_list": [], "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0065010 extracellular membrane-bounded organelle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006953 acute-phase response;GO:0050727 regulation of inflammatory response;GO:0050766 positive regulation of phagocytosis;GO:0030502 negative regulation of bone mineralization", "synthesized_glycan_count": 0, "hit_score": 12.1, "record_id": "P12763-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13272-1", "uniprot_id": [ { "id": "UCRI_BOVIN", "url": "https://www.uniprot.org/uniprot/P13272", "type": "external" } ], "mass": 29547.0, "length": 274, "protein_name": "Cytochrome b-c1 complex subunit Rieske, mitochondrial", "gene_name": "UQCRFS1", "organism": "Bovine", "refseq_name": "cytochrome b-c1 complex subunit Rieske, mitochondrial precursor", "refseq_ac": [ { "id": "NP_777238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777238", "type": "external" } ], "gene_names_uniprotkb": "UQCRFS1", "gene_names_refseq": "RISP; UQCRFS1", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit Rieske, mitochondrial; 7.1.1.8; 8 kDa subunit 9; Complex III subunit 5; Complex III subunit IX; Cytochrome b-c1 complex subunit 11; Cytochrome b-c1 complex subunit 5; RISP; Rieske iron-sulfur protein; Rieske protein UQCRFS1; UQCRFS1 MTS; UQCRFS1 mitochondrial targeting sequence; Ubiquinol-cytochrome c reductase 8 kDa protein; Ubiquinol-cytochrome c reductase iron-sulfur subunit", "protein_names_refseq": "Rieske iron-sulfur protein; Rieske protein UQCRFS1; complex III subunit 5; cytochrome b-c1 complex subunit 5; cytochrome b-c1 complex subunit Rieske, mitochondrial precursor; cytochrome b-c1 complex subunit Rieske, mitochondrial; ubiquinol-cytochrome c reductase iron-sulfur subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:287020); (R-BTA-611105); (R-BTA-9865881)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "11073949;12269811;15312779;15766251;15865449;15878858;16024040;16924113;2157409;2996928;3036596;8386158;8736555;9204897;9651245", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer. One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS) (PubMed:2996928, PubMed:8386158). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; In the normal catalytic cycle of the bc(1) complex, the [2Fe-2S] cluster may function as a proton-exiting gate, [RefSeq, PubMed]; This is the first direct demonstration that histidine is the redox-linked protonation site of the Rieske iron-sulfur protein subunit of cytochrome bc1., [RefSeq, PubMed]; Three hydrogen-bond mutant Rieske clusters all have decreased cluster reduction potentials and increased cluster pK values consistent with the removal of a hydrogen-bonding dipole, which preferentially stabilizes the most negatively charged state., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KN53;P07588;Q1LZH6", "ec_number_list": [ { "id": "7.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P13272-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13608-1", "uniprot_id": [ { "id": "PGCA_BOVIN", "url": "https://www.uniprot.org/uniprot/P13608", "type": "external" } ], "mass": 246362.0, "length": 2364, "protein_name": "Aggrecan core protein", "gene_name": "ACAN", "organism": "Bovine", "refseq_name": "aggrecan core protein precursor", "refseq_ac": [ { "id": "NP_776406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776406", "type": "external" } ], "gene_names_uniprotkb": "ACAN; AGC1", "gene_names_refseq": "ACAN; AGC1", "protein_names_uniprotkb": "Aggrecan core protein; CSPCP; Cartilage-specific proteoglycan core protein", "protein_names_refseq": "CSPCP; aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122); aggrecan core protein precursor; aggrecan core protein; aggrecan epidermal growth factor-like domain-1; cartilage-specific proteoglycan core protein", "tax_id": 9913, "disease": "", "pathway": " (bta:280985)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "16167996;2022637;21081100;21289569;24032649;24843873;2528543;3111460;3530809;37003165;6489519;8349621;8943283;9308898", "class_list": "", "function": "Data show that expression of mRNAs for aggrecan, collagen type II, and versican were significantly effected by the intervention., [RefSeq, PubMed]; Self-adhesion between highly negatively charged aggrecan macromolecules extracted from bovine cartilage extracellular matrix, was investigated., [RefSeq, PubMed]; Structural changes in collagen and aggrecan during extended aging may improve beef tenderness., [RefSeq, PubMed]; The subsequent presentation of aggregan from ECM leads to CD4(+) T-cell activation and effector cell formation., [RefSeq, PubMed]; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage., [UniProtKB]", "predicted_glycosites": 23, "predicted_n_glycosites": 9, "predicted_o_glycosites": 14, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "P79117;Q28159;Q6XL66", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0045202 synapse;GO:0072534 perineuronal net", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P13608-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14099-1", "uniprot_id": [ { "id": "PDE2A_BOVIN", "url": "https://www.uniprot.org/uniprot/P14099", "type": "external" } ], "mass": 103228.0, "length": 921, "protein_name": "cGMP-dependent 3',5'-cyclic phosphodiesterase", "gene_name": "PDE2A", "organism": "Bovine", "refseq_name": "cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3", "refseq_ac": [ { "id": "NP_001137318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137318", "type": "external" } ], "gene_names_uniprotkb": "PDE2A", "gene_names_refseq": "CGS-PDE; PDE2A; cGSPDE", "protein_names_uniprotkb": "cGMP-dependent 3',5'-cyclic phosphodiesterase; 3.1.4.17; CGS-PDE; Cyclic GMP-stimulated phosphodiesterase; cGSPDE", "protein_names_refseq": "c-GMP stimulated phosphodiesterase; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3; cGMP-dependent 3',5'-cyclic phosphodiesterase; cyclic GMP-stimulated phosphodiesterase; phosphodiesterase 2A, cGMP-stimulated", "tax_id": 9913, "disease": "", "pathway": " (bta:281971)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1654333;2176866;3025833;6276403", "class_list": "", "function": "Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L., [UniProtKB, UniProtKB]; cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1654333, PubMed:6276403). Has a higher efficiency with cGMP compared to cAMP (By similarity). Plays a role in cell growth and migration (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q28064", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0061028 establishment of endothelial barrier;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0043116 negative regulation of vascular permeability", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P14099-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14100-1", "uniprot_id": [ { "id": "PDE1A_BOVIN", "url": "https://www.uniprot.org/uniprot/P14100", "type": "external" } ], "mass": 60843.0, "length": 530, "protein_name": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A", "gene_name": "PDE1A", "organism": "Bovine", "refseq_name": "dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A", "refseq_ac": [ { "id": "NP_776839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776839", "type": "external" } ], "gene_names_uniprotkb": "PDE1A", "gene_names_refseq": "PDE1A; PDE1", "protein_names_uniprotkb": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; 3.1.4.17; 61 kDa Cam-PDE; Cam-PDE 1A", "protein_names_refseq": "61 kDa Cam-PDE; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; calmodulin-dependent phosphodiesterase type 1; cam-PDE 1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; nucleotide phosphodiesterase, 3'-5'-cyclic; phosphodiesterase 1A, calmodulin-dependent", "tax_id": 9913, "disease": "", "pathway": " (bta:281969); (R-BTA-111957); (R-BTA-418457); (R-BTA-418555)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12514091;1651111;1651112;17467927;26513204;3025833;7678006;8537356", "class_list": "", "function": "Although cAMP regulation by PDE 1 may occur early during capacitation, downstream events appear to prevent full capacitation from occurring prematurely., [RefSeq, PubMed]; Analysis of calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) splice variants from bovine cardiac muscle, [RefSeq, PubMed]; Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP., [UniProtKB, PubMed]; The original finding was the identification and purification of a vinpocetine and muscarinic antagonist-inhibited and CaM-activated plasma membrane-bound PDE1A, linked to M(2)AChR., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08E30;Q28063", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity;GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P14100-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16068-1", "uniprot_id": [ { "id": "GCYB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P16068", "type": "external" } ], "mass": 70502.0, "length": 619, "protein_name": "Guanylate cyclase soluble subunit beta-1", "gene_name": "GUCY1B1", "organism": "Bovine", "refseq_name": "guanylate cyclase soluble subunit beta-1", "refseq_ac": [ { "id": "NP_777066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777066", "type": "external" } ], "gene_names_uniprotkb": "GUCY1B1; GUC1B3; GUCY1B3", "gene_names_refseq": "GUCY1B1; GUCY1B3", "protein_names_uniprotkb": "Guanylate cyclase soluble subunit beta-1; 4.6.1.2; GCS-beta-1; GCS-beta-3; Guanylate cyclase soluble subunit beta-3; Soluble guanylate cyclase small subunit", "protein_names_refseq": "GCS-beta-1; GCS-beta-3; NO-sensitive GC beta 1 subunit; guanylate cyclase 1, soluble, beta 3; guanylate cyclase soluble subunit beta-1; guanylate cyclase soluble subunit beta-3; nitric oxide-sensitive guanylyl cyclase beta 1 subunit; soluble guanylate cyclase small subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:282433); (R-BTA-445355)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "22223482;26134567;2903071;7908439;9391039;9521770", "class_list": "", "function": "Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP., [UniProtKB, PubMed]; These results suggest a means by which the hsp90beta interaction could prevent apo-sGCbeta1 from associating with its partner sGCalpha1 subunit while enabling structural changes to assist heme insertion into the H-NOX domain., [RefSeq, PubMed]; We concluded that the alpha-subunit and the beta(1)(191-619) domain exert structural strains on the heme domain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2VDM4", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008074 guanylate cyclase complex, soluble", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0071732 cellular response to nitric oxide;GO:0038060 nitric oxide-cGMP-mediated signaling;GO:0070482 response to oxygen levels", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P16068-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16116-1", "uniprot_id": [ { "id": "ALDR_BOVIN", "url": "https://www.uniprot.org/uniprot/P16116", "type": "external" } ], "mass": 35919.0, "length": 315, "protein_name": "Aldo-keto reductase family 1 member B1", "gene_name": "AKR1B1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AKR1B1", "gene_names_refseq": "", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member B1; 1.1.1.21; 1.1.1.300; 1.1.1.372; 1.1.1.54; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; AR; Aldehyde reductase; Aldose reductase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:317748)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16305752;19393038;2105951;2515032;8431420", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids and xenobiotics substrates. It catalyzes the reduction of glucose to sorbitol, the first step of the polyol pathway, an alternative route of glucose metabolism that converts glucose to fructose. This pathway becomes highly active under elevated glucose levels, such as during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MVU2;Q5E962", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.357", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.188", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.188", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" }, { "id": "1.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.19", "type": "external" }, { "id": "1.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.20", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" } ], "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0036130 prostaglandin H2 endoperoxidase reductase activity;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0047956 glycerol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0001523 retinoid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P16116-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16386-1", "uniprot_id": [ { "id": "LIPS_BOVIN", "url": "https://www.uniprot.org/uniprot/P16386", "type": "external" } ], "mass": 82641.0, "length": 756, "protein_name": "Hormone-sensitive lipase", "gene_name": "LIPE", "organism": "Bovine", "refseq_name": "hormone-sensitive lipase", "refseq_ac": [ { "id": "NP_001073689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073689", "type": "external" } ], "gene_names_uniprotkb": "LIPE", "gene_names_refseq": "LIPE; REH; hsl", "protein_names_uniprotkb": "Hormone-sensitive lipase; 3.1.1.23; 3.1.1.79; HSL; Monoacylglycerol lipase LIPE; REH; Retinyl ester hydrolase", "protein_names_refseq": "hormone-sensitive lipase; lipase, hormone-sensitive; monoacylglycerol lipase LIPE; retinyl ester hydrolase", "tax_id": 9913, "disease": "", "pathway": " (bta:286879)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18755148;24213829;2537200;30190510;3345839;33810070;37615121", "class_list": "", "function": "Detection of two SNPs of the LIPE gene in Holstein-Friesian cows with divergent milk production., [RefSeq, PubMed]; Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (By similarity). Shows a preferential hydrolysis of DAGs over TAGs and MAGs (By similarity). Preferentially hydrolyzes fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs and FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Polymorphisms in HSL might be one of important genetic factors that influence carcass yield and meat quality in beef cattle., [RefSeq, PubMed]; Results demonstrate that HSL contribution to basal lipolysis is negligible prepartum. However, HSL is a major driver of SCAT lipolytic responses postpartum. Lower basal lipolysis postpartum suggests that reduced lipogenesis is an important contributor to fatty acid release from SCAT. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest that HSL was regulated by fatty acids and some hormones in mammary epithelial cells and thereby play an important role of lipid and energy metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1YWA8;Q562H4", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.71", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0047372 monoacylglycerol lipase activity;GO:0004806 triacylglycerol lipase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0016042 lipid catabolic process;GO:0046340 diacylglycerol catabolic process;GO:0019433 triglyceride catabolic process;GO:0046485 ether lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P16386-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17810-1", "uniprot_id": [ { "id": "PRPH2_BOVIN", "url": "https://www.uniprot.org/uniprot/P17810", "type": "external" } ], "mass": 39123.0, "length": 346, "protein_name": "Peripherin-2", "gene_name": "PRPH2", "organism": "Bovine", "refseq_name": "peripherin-2", "refseq_ac": [ { "id": "NP_001159959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159959", "type": "external" } ], "gene_names_uniprotkb": "PRPH2; RDS", "gene_names_refseq": "PRPH2; RDS", "protein_names_uniprotkb": "Peripherin-2; Retinal degeneration slow protein", "protein_names_refseq": "peripherin-2; retinal degeneration slow protein; retinal degeneration, slow; retinitis pigmentosa 7", "tax_id": 9913, "disease": "", "pathway": " (bta:280907)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10681511;14767063;17260955;2372552;24196967;28325841", "class_list": "", "function": "Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (PubMed:24196967). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity)., [UniProtKB, UniProtKB, PubMed]; Significantly strengthens the evidence that peripherin-2/rds functions directly to shape the high-curvature rim domains of the outer segment disk; that the protein's C terminus may modulate membrane curvature-generating activity present in other protein domains, [RefSeq, PubMed]; The C terminus of peripherin/rds has roles in targeting and maintaining ROS structure and is potentially involved in retinal degenerations, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0072659 protein localization to plasma membrane;GO:0007601 visual perception;GO:0051604 protein maturation;GO:0051258 protein polymerization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P17810-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19120-1", "uniprot_id": [ { "id": "HSP7C_BOVIN", "url": "https://www.uniprot.org/uniprot/P19120", "type": "external" } ], "mass": 71241.0, "length": 650, "protein_name": "Heat shock cognate 71 kDa protein", "gene_name": "HSPA8", "organism": "Bovine", "refseq_name": "heat shock cognate 71 kDa protein", "refseq_ac": [ { "id": "NP_776770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776770", "type": "external" } ], "gene_names_uniprotkb": "HSPA8; HSC70", "gene_names_refseq": "HSPA10; HSPA8; Hsc70", "protein_names_uniprotkb": "Heat shock cognate 71 kDa protein; 3.6.4.10; Heat shock 70 kDa protein 8", "protein_names_refseq": "Hsc70 ATPase; heat shock 70 kDa protein 8; heat shock 70kDa protein 8; heat shock 70kd protein 10 (HSC71); heat shock cognate 71 kD protein; heat shock cognate 71 kDa protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281831); (R-BTA-3371453); (R-BTA-3371497); (R-BTA-3371568); (R-BTA-3371571); (R-BTA-450408); (R-BTA-6798695); (R-BTA-72163); (R-BTA-8856828); (R-BTA-8876725); (R-BTA-888590); (R-BTA-9833482)", "pathway_count": 12, "publication_count": 15, "publication_id_list": "10451379;16305752;17996706;18550409;19812207;20033059;20434583;21278753;2143562;2216746;41018975;8175707;8524399;9585559;9799500", "class_list": "", "function": "Elevated expression of bovine heat shock cognate (hsc)70 protein increases diabetes and inflammation following islet beta cell damage in a transgenic mouse model., [RefSeq, PubMed]; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2. KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded. In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (PubMed:17996706, PubMed:8524399)., [UniProtKB, PubMed, PubMed, UniProtKB]; Single-particle fluorescence imaging tracks the dynamics of Hsc70 and its clathrin substrate in real time., [RefSeq, PubMed]; Structure of clathrin coat with bound Hsc70 and auxilin., [RefSeq, PubMed]; The interaction of the molecular chaperone Hsc70 (HSPA8) with recombinant PrP was investigated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D968;Q3MHM4", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" 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"3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "4.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.15", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": 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"external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0045892 negative regulation of DNA-templated transcription;GO:0008380 RNA splicing;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P19120-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19427-1", "uniprot_id": [ { "id": "DERM_BOVIN", "url": "https://www.uniprot.org/uniprot/P19427", "type": "external" } ], "mass": 24012.0, "length": 201, "protein_name": "Dermatopontin", "gene_name": "DPT", "organism": "Bovine", "refseq_name": "dermatopontin precursor", "refseq_ac": [ { "id": "NP_001039368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039368", "type": "external" } ], "gene_names_uniprotkb": "DPT", "gene_names_refseq": "DPT", "protein_names_uniprotkb": "Dermatopontin; 22 kDa extracellular matrix protein; Dermatan sulfate proteoglycan-associated protein 22K; TRAMP; Tyrosine-rich acidic matrix protein", "protein_names_refseq": "22 kDa extracellular matrix protein; TRAMP; dermatan sulfate proteoglycan-associated protein 22K; dermatopontin precursor; tyrosine-rich acidic matrix protein", "tax_id": 9913, "disease": "", "pathway": " (bta:504963)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1939376;2925615;8907183;9895299", "class_list": "", "function": "Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29S18", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "", "go_biological_process": "GO:0007155 cell adhesion;GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P19427-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19483-1", "uniprot_id": [ { "id": "ATPA_BOVIN", "url": "https://www.uniprot.org/uniprot/P19483", "type": "external" } ], "mass": 59720.0, "length": 553, "protein_name": "ATP synthase F(1) complex subunit alpha, mitochondrial", "gene_name": "ATP5F1A", "organism": "Bovine", "refseq_name": "ATP synthase F(1) complex subunit alpha, mitochondrial precursor", "refseq_ac": [ { "id": "NP_777109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777109", "type": "external" } ], "gene_names_uniprotkb": "ATP5F1A; ATP5A1; ATP5A2", "gene_names_refseq": "ATP5A1; ATP5F1A", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit alpha, mitochondrial; ATP synthase F1 subunit alpha", "protein_names_refseq": "ATP synthase F(1) complex subunit alpha, mitochondrial precursor; ATP synthase F(1) complex subunit alpha, mitochondrial; ATP synthase alpha subunit; ATP synthase subunit alpha, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle", "tax_id": 9913, "disease": "", "pathway": " (bta:282578)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "12923572;1420306;14633978;17570365;17698806;17895376;23055519;23407638;2527557;25851905;26439008;28100784;2864455;2896000;31554800;41018975;8065448;8790345;95168;9687365", "class_list": "", "function": "Combining cryoelectron microscopy data with bioinformatic analysis allowed the authors to determine the fold of the a subunit, suggesting a proton translocation path through the FO region that involves both the a and b subunits. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that bovine F-ATP synthase was capable to hydrolyze Ca2+-ATP. Publication Status: Online-Only, [RefSeq, PubMed]; F1-ATPase at the cell surface of colonic epithelial cells has a role in mediating cell proliferation, [RefSeq, PubMed]; Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (PubMed:23407638). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity)., [UniProtKB, PubMed, UniProtKB]; The beneficial effects of dietary resveratrol may derive in part by preventing mitochondrial ATP synthesis in tumor cells, thereby inducing apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P05629;P19482;Q1JQC4", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043531 ADP binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P19483-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19754-1", "uniprot_id": [ { "id": "ADCY1_BOVIN", "url": "https://www.uniprot.org/uniprot/P19754", "type": "external" } ], "mass": 123979.0, "length": 1134, "protein_name": "Adenylate cyclase type 1", "gene_name": "ADCY1", "organism": "Bovine", "refseq_name": "adenylate cyclase type 1", "refseq_ac": [ { "id": "NP_776654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776654", "type": "external" } ], "gene_names_uniprotkb": "ADCY1", "gene_names_refseq": "AC1; ADCY1", "protein_names_uniprotkb": "Adenylate cyclase type 1; 4.6.1.1; AC1; ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase", "protein_names_refseq": "ATP pyrophosphate-lyase 1; adenylate cyclase 1 (brain); adenylate cyclase type 1; adenylate cyclase type I; adenylyl cyclase 1; ca(2+)/calmodulin-activated adenylyl cyclase", "tax_id": 9913, "disease": "", "pathway": " (bta:281601); (R-BTA-163615); (R-BTA-170660); (R-BTA-170670); (R-BTA-418597); (R-BTA-5610787)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "19029295;2022671;2472670;8119955;9391039", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:19029295, PubMed:2022671, PubMed:2472670, PubMed:8119955). Mediates responses to increased cellular Ca(2+)/calmodulin levels (PubMed:19029295, PubMed:2022671). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0098793 presynapse", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P19754-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19879-1", "uniprot_id": [ { "id": "MIME_BOVIN", "url": "https://www.uniprot.org/uniprot/P19879", "type": "external" } ], "mass": 34196.0, "length": 299, "protein_name": "Mimecan", "gene_name": "OGN", "organism": "Bovine", "refseq_name": "mimecan precursor", "refseq_ac": [ { "id": "NP_776371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776371", "type": "external" } ], "gene_names_uniprotkb": "OGN; OIF", "gene_names_refseq": "OGN", "protein_names_uniprotkb": "Mimecan; Osteoglycin", "protein_names_refseq": "mimecan precursor; mimecan; osteoglycin (osteoinductive factor); osteoglycin (osteoinductive factor, mimecan); osteoglycin preproprotein", "tax_id": 9913, "disease": "", "pathway": " (bta:280884); (R-BTA-2022854); (R-BTA-2022857)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10373482;2139877;2180954;2372374;2584240;9346963", "class_list": "", "function": "Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A5D9E8;O18818", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix", "go_biological_process": "GO:0060348 bone development;GO:0061975 articular cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P19879-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20274-1", "uniprot_id": [ { "id": "LMIP_BOVIN", "url": "https://www.uniprot.org/uniprot/P20274", "type": "external" } ], "mass": 19684.0, "length": 173, "protein_name": "Lens fiber membrane intrinsic protein", "gene_name": "LIM2", "organism": "Bovine", "refseq_name": "lens fiber membrane intrinsic protein", "refseq_ac": [ { "id": "NP_776527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776527", "type": "external" } ], "gene_names_uniprotkb": "LIM2", "gene_names_refseq": "LIM2", "protein_names_uniprotkb": "Lens fiber membrane intrinsic protein; MP18; MP19; MP20; MP21; MP23", "protein_names_refseq": "MP18; MP19; MP20; MP21; MP23; intrinsic membrane protein 2; lens fiber membrane intrinsic protein; lens intrinsic membrane protein 2, 19kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:281282)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15671292;2276272;2473922;2584203", "class_list": "", "function": "Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 2, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 2, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 2, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 2, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P20274-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0010000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21146-1", "uniprot_id": [ { "id": "GRK2_BOVIN", "url": "https://www.uniprot.org/uniprot/P21146", "type": "external" } ], "mass": 79647.0, "length": 689, "protein_name": "G protein-coupled receptor kinase 2", "gene_name": "GRK2", "organism": "Bovine", "refseq_name": "beta-adrenergic receptor kinase 1", "refseq_ac": [ { "id": "NP_777135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777135", "type": "external" } ], "gene_names_uniprotkb": "GRK2; ADRBK1", "gene_names_refseq": "ADRBK1; GRK2", "protein_names_uniprotkb": "G protein-coupled receptor kinase 2; 2.7.11.15; 2.7.11.16; Beta-ARK-1; Beta-adrenergic receptor kinase 1", "protein_names_refseq": "adrenergic, beta, receptor kinase 1; beta-ARK-1; beta-adrenergic receptor kinase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282682); (R-BTA-111933); (R-BTA-416476); (R-BTA-418555); (R-BTA-5635838); (R-BTA-8856825)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10508278;12764189;15157420;21659505;21826651;23467820;2552582;27088923;9826657", "class_list": "", "function": "Indicate that the anti-proliferative function of elevated GRK2 in hepatocellular carcinoma is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent., [RefSeq, PubMed]; Mitochondrial-targeted GRK2 is essential for prodeath signaling occurring after oxidative stress in myocytes and assigning a novel role for this GRK., [RefSeq, PubMed]; Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:10508278, PubMed:21659505). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:10508278, PubMed:21659505). Phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (By similarity). Phosphorylates catecholamine-activated ADRB2 to regulate physiological cardiomyocyte contraction rate responses (By similarity). Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (PubMed:10508278). Key regulator of LPAR1 signaling (By similarity). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO) signaling pathway by mediating phosphorylation of SMO, facilitating SMO trafficking into the cilium and the stimulation of SMO activity (PubMed:21659505). Also positively regulates SMO signaling by mediating phosphorylation of GPR161, a key inhibitor SMO signaling, promoting ciliary export of GPR161 (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; The PIP2-induced orientation of the GRK2-Gbeta1gamma2 complex is therefore most likely caused by specific interactions between PIP2 and the GRK2 PH domain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0001664 G protein-coupled receptor binding;GO:0031694 alpha-2A adrenergic receptor binding;GO:0004703 G protein-coupled receptor kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0006886 intracellular protein transport;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P21146-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21457-1", "uniprot_id": [ { "id": "RECO_BOVIN", "url": "https://www.uniprot.org/uniprot/P21457", "type": "external" } ], "mass": 23333.0, "length": 202, "protein_name": "Recoverin", "gene_name": "RCVRN", "organism": "Bovine", "refseq_name": "recoverin", "refseq_ac": [ { "id": "NP_776590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776590", "type": "external" } ], "gene_names_uniprotkb": "RCVRN; RCV1", "gene_names_refseq": "RCV1; RCVRN", "protein_names_uniprotkb": "Recoverin; p26", "protein_names_refseq": "p26; recoverin", "tax_id": 9913, "disease": "", "pathway": " (bta:281447); (R-BTA-2514859)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "11462170;11980481;12686556;1385864;1386601;1454850;16675451;1672047;1672637;17015448;17020884;17078090;18034895;1959664;21299498;21465563;24189072;25772009;26584024;7630423;8097896;8242744;8392055;8430337;9296500", "class_list": "", "function": "(15) N NMR relaxation data suggest that Ca(2+)-free recoverin undergoes millisecond conformational dynamics at particular amide sites throughout the protein., [RefSeq, PubMed]; A novel rhodopsin-kinase-binding site within the C-terminal region of recoverin., [RefSeq, PubMed]; Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (PubMed:1672047, PubMed:1672637). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (PubMed:12686556, PubMed:16675451, PubMed:1672047, PubMed:1672637, PubMed:17015448, PubMed:21299498, PubMed:8392055). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Properties of the charged carboxy-terminus are consistent with a role of this region as an internal effector region that prolongs the time recoverin stays on the membrane by influencing its Ca2+-sensitivity Publication Status: Online-Only, [RefSeq, PubMed]; Time-resolved fluorescence shows biexponential fluorescence decay. The slower time constant was affected by Ca2+-induced conformational changes in WT & RecE85Q (disabled EF-hand 2), & not RecE121Q (EF-hand 3 nonfunctional) with a clamped myristoyl group., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0043204 perikaryon;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007601 visual perception;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P21457-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21809-1", "uniprot_id": [ { "id": "PGS1_BOVIN", "url": "https://www.uniprot.org/uniprot/P21809", "type": "external" } ], "mass": 41590.0, "length": 369, "protein_name": "Biglycan", "gene_name": "BGN", "organism": "Bovine", "refseq_name": "biglycan precursor", "refseq_ac": [ { "id": "NP_847888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_847888", "type": "external" } ], "gene_names_uniprotkb": "BGN", "gene_names_refseq": "BGN", "protein_names_uniprotkb": "Biglycan; Bone/cartilage proteoglycan I; Leucine-rich PG I; PG-S1", "protein_names_refseq": "PG-S1; biglycan precursor; bone/cartilage proteoglycan I; leucine-rich PG I", "tax_id": 9913, "disease": "", "pathway": " (bta:280733); (R-BTA-1971475); (R-BTA-2022870); (R-BTA-2022923); (R-BTA-2024101); (R-BTA-3000178)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "11723132;16305752;16547006;20386503;2656687;2914936;8673009", "class_list": "", "function": "Data show that biglycan, collagen type I, collagen type II, decorin, and versican were significantly affected by vibration duration, frequency, and amplitude., [RefSeq, PubMed]; May be involved in collagen fiber assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "P79259;Q17QB0;Q5BIM3", "ec_number_list": [], "go_molecular_function": "GO:0050840 extracellular matrix binding;GO:0019955 cytokine binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0030133 transport vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P21809-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22457-1", "uniprot_id": [ { "id": "FA7_BOVIN", "url": "https://www.uniprot.org/uniprot/P22457", "type": "external" } ], "mass": 48961.0, "length": 447, "protein_name": "Coagulation factor VII", "gene_name": "F7", "organism": "Bovine", "refseq_name": "coagulation factor VII precursor", "refseq_ac": [ { "id": "NP_001029978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029978", "type": "external" } ], "gene_names_uniprotkb": "F7", "gene_names_refseq": "F7", "protein_names_uniprotkb": "Coagulation factor VII; 3.4.21.21; Serum prothrombin conversion accelerator", "protein_names_refseq": "coagulation factor VII precursor; serum prothrombin conversion accelerator", "tax_id": 9913, "disease": "", "pathway": " (bta:617960); (R-BTA-159740); (R-BTA-159763); (R-BTA-159782); (R-BTA-9769735); (R-BTA-9769739)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "16305752;2129367;3049594;3149637", "class_list": "", "function": "Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A6H6Y5;Q58DL3", "ec_number_list": [ { "id": "3.4.21.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.22", "type": "external" }, { "id": "3.4.21.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6", "type": "external" }, { "id": "3.4.21.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.21", "type": "external" }, { "id": "4.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016485 protein processing;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P22457-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23389-1", "uniprot_id": [ { "id": "SCG1_BOVIN", "url": "https://www.uniprot.org/uniprot/P23389", "type": "external" } ], "mass": 73340.0, "length": 646, "protein_name": "Secretogranin-1", "gene_name": "CHGB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CHGB", "gene_names_refseq": "", "protein_names_uniprotkb": "Secretogranin-1; CgB; Chromogranin-B; Secretogranin I; SgI", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281071)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11584008;1350945;15174145;1554736;1982622;2025642;7744058;8218367;8603705;9136897", "class_list": "", "function": "Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. The 16 pairs of basic AA distributed throughout its sequence may be used as proteolytic cleavage sites., [UniProtKB]; Secretolytin has antibacterial activity., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O02707", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0030658 transport vesicle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P23389-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23439-1", "uniprot_id": [ { "id": "PDE6B_BOVIN", "url": "https://www.uniprot.org/uniprot/P23439", "type": "external" } ], "mass": 98331.0, "length": 853, "protein_name": "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta", "gene_name": "PDE6B", "organism": "Bovine", "refseq_name": "rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta", "refseq_ac": [ { "id": "NP_776843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776843", "type": "external" } ], "gene_names_uniprotkb": "PDE6B; PDEB", "gene_names_refseq": "PDE6B", "protein_names_uniprotkb": "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; 3.1.4.35; GMP-PDE beta", "protein_names_refseq": "GMP-PDE beta; phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant); phosphodiesterase, cyclic GMP (rod receptor), beta polypeptide; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta", "tax_id": 9913, "disease": "", "pathway": " (bta:281974)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12372317;15668239;2161230;2165490;25809480;31394113;31690623;33007200;38159849", "class_list": "", "function": "A structural basis for interpreting how mutations in rod PDE6 subunits can lead to retinal diseases, is discussed., [RefSeq, PubMed]; Analysis of the Rod PDE6 holoenzyme (subunit composition, alphabetagammagamma) reveals the mechanism of visual excitation, [RefSeq, PubMed]; Catalytic beta subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PDE6G) (PubMed:33007200, PubMed:38159849). Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification (PubMed:33007200, PubMed:38159849). Decreased cytosolic cGMP levels result in closure of cGMP-gated cation channels at the plasma membrane, leading to rod photoreceptor hyperpolarization (Probable). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Structural analysis of cGMP phosphodiesterase 6 alpha, beta and gamma interactions, [RefSeq, PubMed]; Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6. Erratum:[Mol Cell. 2021 Jun 3;81(11):2496. doi: 10.1016/j.molcel.2021.05.006. PMID: 34087182], [RefSeq, PubMed]; The approximately 11 A map revealed previously unseen features of PDE6, and each domain was readily fit with high resolution structures. Erratum:[J Biol Chem. 2015 Jul 10;290(28):17131-2. doi: 10.1074/jbc.A115.647636. PMID: 26163476], [RefSeq, PubMed]; The unique Palphabeta heterodimer contributes to the sophisticated regulation in visual transduction through interaction with Pgamma, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0097381 photoreceptor disc membrane;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0060041 retina development in camera-type eye;GO:0043153 entrainment of circadian clock by photoperiod;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P23439-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23727-1", "uniprot_id": [ { "id": "P85A_BOVIN", "url": "https://www.uniprot.org/uniprot/P23727", "type": "external" } ], "mass": 83497.0, "length": 724, "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "PIK3R1", "organism": "Bovine", "refseq_name": "phosphatidylinositol 3-kinase regulatory subunit alpha", "refseq_ac": [ { "id": "NP_777000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777000", "type": "external" } ], "gene_names_uniprotkb": "PIK3R1", "gene_names_refseq": "PIK3R1", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory subunit p85-alpha", "protein_names_refseq": "PI3-kinase p85 subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha); phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:282307); (R-BTA-109704); (R-BTA-112399); (R-BTA-114604); (R-BTA-1250342); (R-BTA-1257604); (R-BTA-1266695); (R-BTA-1433557); (R-BTA-1660499); (R-BTA-180292); (R-BTA-186763); (R-BTA-1963642); (R-BTA-198203); (R-BTA-201556); (R-BTA-202424); (R-BTA-2029485); (R-BTA-210993); (R-BTA-2424491); (R-BTA-2730905); (R-BTA-389357); (R-BTA-416476); (R-BTA-430116); (R-BTA-4420097); (R-BTA-512988); (R-BTA-5654689); (R-BTA-5654695); (R-BTA-5654710); (R-BTA-5654720); (R-BTA-5673001); (R-BTA-6811558); (R-BTA-8851907); (R-BTA-8853659); (R-BTA-8980692); (R-BTA-9009391); (R-BTA-9013106); (R-BTA-9013148); (R-BTA-9013404); (R-BTA-9013408); (R-BTA-9013409); (R-BTA-9013420); (R-BTA-9013423); (R-BTA-9013424); (R-BTA-9027276); (R-BTA-9035034); (R-BTA-912526); (R-BTA-912631); (R-BTA-9607240); (R-BTA-9696264); (R-BTA-9696270); (R-BTA-9696273); (R-BTA-983695); (R-BTA-9927354)", "pathway_count": 52, "publication_count": 9, "publication_id_list": "1323062;1330535;1375321;14729945;1707345;22366926;7684655;8952511;9512716", "class_list": "", "function": "Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The p85alpha regulatory subunit of PI3K mediates cAMP-PKA and retinoic acid biological effects on MCF7 cell growth and migration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005158 insulin receptor binding;GO:0042802 identical protein binding;GO:0005159 insulin-like growth factor receptor binding;GO:0046935 1-phosphatidylinositol-3-kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005942 phosphatidylinositol 3-kinase complex;GO:0005943 phosphatidylinositol 3-kinase complex, class IA;GO:0005829 cytosol;GO:0005911 cell-cell junction", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0033120 positive regulation of RNA splicing;GO:0015031 protein transport;GO:0032869 cellular response to insulin stimulus;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P23727-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27424-1", "uniprot_id": [ { "id": "MFAP2_BOVIN", "url": "https://www.uniprot.org/uniprot/P27424", "type": "external" } ], "mass": 20709.0, "length": 183, "protein_name": "Microfibrillar-associated protein 2", "gene_name": "MFAP2", "organism": "Bovine", "refseq_name": "microfibrillar-associated protein 2 precursor", "refseq_ac": [ { "id": "NP_776813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776813", "type": "external" } ], "gene_names_uniprotkb": "MFAP2; MAGP1; MAGP", "gene_names_refseq": "MFAP2", "protein_names_uniprotkb": "Microfibrillar-associated protein 2; MAGP-1; MAGP; MFAP-2; Microfibril-associated glycoprotein 1; Tropoelastin-binding protein", "protein_names_refseq": "MAGP-1; MAGP; MFAP-2; microfibril-associated glycoprotein 1; microfibrillar associated protein 2; microfibrillar-associated protein 2 precursor; precursor; tropoelastin-binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281912)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11284693;11723132;15131124;2019589;3015971;8286390", "class_list": "", "function": "Component of the elastin-associated microfibrils., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001527 microfibril", "go_biological_process": "GO:0048048 embryonic eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P27424-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28088-1", "uniprot_id": [ { "id": "EDNRB_BOVIN", "url": "https://www.uniprot.org/uniprot/P28088", "type": "external" } ], "mass": 49371.0, "length": 441, "protein_name": "Endothelin receptor type B", "gene_name": "EDNRB", "organism": "Bovine", "refseq_name": "endothelin receptor type B precursor", "refseq_ac": [ { "id": "NP_776734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776734", "type": "external" } ], "gene_names_uniprotkb": "EDNRB", "gene_names_refseq": "EDNRB", "protein_names_uniprotkb": "Endothelin receptor type B; ET-BR; ET-B; Endothelin receptor non-selective type", "protein_names_refseq": "ET-BR; ET-B; endothelin B receptor; endothelin receptor non-selective type; endothelin receptor type B precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281750); (R-BTA-375276); (R-BTA-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15838292;1653249;1660473;22921266;8529649;9422751", "class_list": "", "function": "Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy., [RefSeq, PubMed]; Elevated local expression of ET-1 and Ednra/Ednrb during the peri-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport., [RefSeq, PubMed]; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VCB3;Q9TSB9", "ec_number_list": [], "go_molecular_function": "GO:0004962 endothelin receptor activity;GO:0017046 peptide hormone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0014043 negative regulation of neuron maturation;GO:0035645 enteric smooth muscle cell differentiation;GO:0048484 enteric nervous system development;GO:0086100 endothelin receptor signaling pathway;GO:1904383 response to sodium phosphate", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P28088-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28339-1", "uniprot_id": [ { "id": "DPOD1_BOVIN", "url": "https://www.uniprot.org/uniprot/P28339", "type": "external" } ], "mass": 123709.0, "length": 1106, "protein_name": "DNA polymerase delta catalytic subunit", "gene_name": "POLD1", "organism": "Bovine", "refseq_name": "DNA polymerase delta catalytic subunit", "refseq_ac": [ { "id": "NP_776852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776852", "type": "external" } ], "gene_names_uniprotkb": "POLD1", "gene_names_refseq": "POLD1", "protein_names_uniprotkb": "DNA polymerase delta catalytic subunit; 2.7.7.7; 3'-5' exodeoxyribonuclease; 3.1.11.-", "protein_names_refseq": "3'-5' exodeoxyribonuclease; DAN polymerase delta 1, catalytic subunit; DNA polymerase delta catalytic subunit; DNA-directed DNA polymerase delta 1; polymerase (DNA directed), delta 1, catalytic subunit 125kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:281990)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10751307;11593007;12522211;1721537", "class_list": "", "function": "As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0008296 3'-5'-DNA exonuclease activity;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0043625 delta DNA polymerase complex", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0006287 base-excision repair, gap-filling;GO:0045004 DNA replication proofreading;GO:0055089 fatty acid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P28339-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29473-1", "uniprot_id": [ { "id": "NOS3_BOVIN", "url": "https://www.uniprot.org/uniprot/P29473", "type": "external" } ], "mass": 133287.0, "length": 1205, "protein_name": "Nitric oxide synthase 3", "gene_name": "NOS3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NOS3", "gene_names_refseq": "", "protein_names_uniprotkb": "Nitric oxide synthase 3; 1.14.13.39; Constitutive NOS; EC-NOS; Endothelial NOS; NOS type III; NOSIII; Nitric oxide synthase, endothelial; cNOS; eNOS", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 15, "publication_id_list": "11051558;11331003;11331290;11590164;11695891;12384459;1378626;1379225;1385480;17071725;22496241;28844813;7682550;8524847;9875848", "class_list": "", "function": "Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0007596 blood coagulation;GO:0045776 negative regulation of blood pressure;GO:0007263 nitric oxide mediated signal transduction;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P29473-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30404-1", "uniprot_id": [ { "id": "PPIF_BOVIN", "url": "https://www.uniprot.org/uniprot/P30404", "type": "external" } ], "mass": 22019.0, "length": 208, "protein_name": "Peptidyl-prolyl cis-trans isomerase F, mitochondrial", "gene_name": "PPIF", "organism": "Bovine", "refseq_name": "peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001001597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001597", "type": "external" } ], "gene_names_uniprotkb": "PPIF; CYP3", "gene_names_refseq": "CyP-D; CypD; PPIF", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase F, mitochondrial; 5.2.1.8; CyP-D; Cyclophilin D; Cyclophilin F; CypD; PPIase F; Rotamase F", "protein_names_refseq": "PPIase F; cyclophilin D; cyclophilin F; peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor; peptidyl-prolyl cis-trans isomerase F, mitochondrial; peptidyl-prolyl cis-trans isomerase, mitochondrial; rotamase F", "tax_id": 9913, "disease": "", "pathway": " (bta:414346)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18765728;19801635;21220005;7679902", "class_list": "", "function": "LKT-mediated cell death involve dynamin-2 and cyclophilin D., [RefSeq, PubMed]; Mannheimia haemolytica leukotoxin binds cyclophilin D on bovine neutrophil mitochondria., [RefSeq, PubMed]; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (By similarity). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PMK8", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005757 mitochondrial permeability transition pore complex", "go_biological_process": "GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death;GO:0002931 response to ischemia;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P30404-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31096-1", "uniprot_id": [ { "id": "OSTP_BOVIN", "url": "https://www.uniprot.org/uniprot/P31096", "type": "external" } ], "mass": 30904.0, "length": 278, "protein_name": "Osteopontin", "gene_name": "SPP1", "organism": "Bovine", "refseq_name": "osteopontin precursor", "refseq_ac": [ { "id": "NP_776612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776612", "type": "external" } ], "gene_names_uniprotkb": "SPP1; OPN", "gene_names_refseq": "OPN; OST; SPP1", "protein_names_uniprotkb": "Osteopontin; Bone sialoprotein 1; SPP-1; Secreted phosphoprotein 1", "protein_names_refseq": "SPP-1; bone sialoprotein 1; bone sialoprotein I; early T-lymphocyte activation 1; osteopontin precursor; osteopontin-K; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)", "tax_id": 9913, "disease": "", "pathway": " (bta:281499)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15867146;15998908;1721033;24327307;24928493;24961487;25316140;28561851;8320368;8535240;8663267;9880554", "class_list": "", "function": "Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity., [UniProtKB, UniProtKB]; Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk., [RefSeq, PubMed]; Major non-collagenous bone protein that binds tightly to hydroxyapatite (Probable). Appears to form an integral part of the mineralized matrix (Probable). Probably important to cell-matrix interaction (Probable)., [UniProtKB, PubMed]; Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells., [RefSeq, PubMed]; Results suggest a mechanism of the interaction of UO2(2+) with bone metabolism and a new role for osteopontin (OPN) as a metal transporter., [RefSeq, PubMed]; Study first addressed in detail the LF/fOPN interaction and proposed a LF:fOPN 4/1 maximal stoichiometry., [RefSeq, PubMed]; This implies that a majority of the acidic residues within OPN must be engaged in calcium interaction under physiological conditions., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 37, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q56NM9;Q8SPS6", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005125 cytokine activity;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007155 cell adhesion;GO:0045780 positive regulation of bone resorption;GO:0031214 biomineral tissue development;GO:0001649 osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P31096-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31976-1", "uniprot_id": [ { "id": "EZRI_BOVIN", "url": "https://www.uniprot.org/uniprot/P31976", "type": "external" } ], "mass": 68760.0, "length": 581, "protein_name": "Ezrin", "gene_name": "EZR", "organism": "Bovine", "refseq_name": "ezrin", "refseq_ac": [ { "id": "NP_776642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776642", "type": "external" } ], "gene_names_uniprotkb": "EZR; VIL2", "gene_names_refseq": "EZR; VIL2", "protein_names_uniprotkb": "Ezrin; Cytovillin; Villin-2; p81", "protein_names_refseq": "cytovillin; ezrin; p81; villin 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281574); (R-BTA-373752)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14625392;19038867;26116960;29167409;8660651", "class_list": "", "function": "Ezrin and CK18 are downregulated during implantation in cattle. The expression changes represent a temporal depolarization, which could be important for an establishment of bovine pregnancy., [RefSeq, PubMed]; Ezrin-dependent, membrane-specific translocation and activation of calpain by VEGF precedes AMPK and AKT-dependent phosphorylation of eNOSs1179 and production of NO., [RefSeq, PubMed]; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity)., [UniProtKB]; Study defines a novel role for the sphingosine kinase-S1P-ERM pathways in phosphate-induced vascular smooth muscle cells matrix mineralization and shows that blocking these pathways with pharmacological inhibitors reduces mineralization; these results may inform new therapeutic approaches to inhibit or delay vascular calcification, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCB9", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding;GO:0050839 cell adhesion molecule binding;GO:0034236 protein kinase A catalytic subunit binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:1902115 regulation of organelle assembly;GO:0051017 actin filament bundle assembly;GO:0008360 regulation of cell shape;GO:2000643 positive regulation of early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P31976-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37359-1", "uniprot_id": [ { "id": "MT3_BOVIN", "url": "https://www.uniprot.org/uniprot/P37359", "type": "external" } ], "mass": 6937.0, "length": 68, "protein_name": "Metallothionein-3", "gene_name": "MT3", "organism": "Bovine", "refseq_name": "metallothionein-3", "refseq_ac": [ { "id": "NP_001106775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106775", "type": "external" } ], "gene_names_uniprotkb": "MT3", "gene_names_refseq": "MT3", "protein_names_uniprotkb": "Metallothionein-3; GIF; Growth inhibitory factor; MT-3; MT-III; Metallothionein-III", "protein_names_refseq": "GIF; MT-3; MT-III; growth inhibitory factor; metallothionein-3; metallothionein-III", "tax_id": 9913, "disease": "", "pathway": " (bta:613320); (R-BTA-5661231)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8200454", "class_list": "", "function": "Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JNL9", "ec_number_list": [], "go_molecular_function": "GO:0046870 cadmium ion binding;GO:0008270 zinc ion binding;GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0008021 synaptic vesicle;GO:0016234 inclusion body", "go_biological_process": "GO:0006829 zinc ion transport;GO:0001934 positive regulation of protein phosphorylation;GO:0010628 positive regulation of gene expression;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P37359-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42026-1", "uniprot_id": [ { "id": "NDUS7_BOVIN", "url": "https://www.uniprot.org/uniprot/P42026", "type": "external" } ], "mass": 23771.0, "length": 216, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "gene_name": "NDUFS7", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001033111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033111", "type": "external" } ], "gene_names_uniprotkb": "NDUFS7", "gene_names_refseq": "NDUFS7", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; 7.1.1.2; CI-20kD; Complex I-20kD; NADH-ubiquinone oxidoreductase 20 kDa subunit; PSST subunit", "protein_names_refseq": "CI-20kD; NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial precursor; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; NADH-ubiquinone oxidoreductase 20 kDa subunit; PSST subunit; complex I-20kD", "tax_id": 9913, "disease": "", "pathway": " (bta:338079); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10852722;1577158;18721790;23836892;25209663;28100784", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790). Essential for the catalytic activity of complex I (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TBS6", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0048038 quinone binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0009060 aerobic respiration;GO:0015990 electron transport coupled proton transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P42026-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43033-1", "uniprot_id": [ { "id": "LIS1_BOVIN", "url": "https://www.uniprot.org/uniprot/P43033", "type": "external" } ], "mass": 46613.0, "length": 410, "protein_name": "Platelet-activating factor acetylhydrolase IB subunit beta", "gene_name": "PAFAH1B1", "organism": "Bovine", "refseq_name": "platelet-activating factor acetylhydrolase IB subunit beta", "refseq_ac": [ { "id": "NP_777088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777088", "type": "external" } ], "gene_names_uniprotkb": "PAFAH1B1; LIS1; PAFAHA", "gene_names_refseq": "LIS-1; LIS1; MDCR; PAFAH1B1", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase IB subunit beta; LIS-1; Lissencephaly-1 protein; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha", "protein_names_refseq": "Miller-Dieker syndrome chromosome region; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; lissencephaly-1 protein; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); platelet-activating factor acetylhydrolase IB subunit alpha; platelet-activating factor acetylhydrolase IB subunit beta", "tax_id": 9913, "disease": "", "pathway": " (bta:282513)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10542206;10940388;11056532;14584027;23262398;8028668", "class_list": "", "function": "PAFAH Ib phospholipase A2 subunits have distinct roles in maintaining Golgi structure and function., [RefSeq, PubMed]; Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in the PAF inactivation (PubMed:10542206). Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (PubMed:10542206). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing (By similarity). Required for pronuclear migration during fertilization. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (By similarity). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, HAMAP]; Results suggest that LIS1 is essential to mediate genomic union in a process that involves the dynein-dynactin complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008201 heparin binding;GO:0046982 protein heterodimerization activity;GO:0070840 dynein complex binding;GO:0043274 phospholipase binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0005874 microtubule;GO:0031965 nuclear membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0051301 cell division;GO:0016042 lipid catabolic process;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P43033-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45478-1", "uniprot_id": [ { "id": "PPT1_BOVIN", "url": "https://www.uniprot.org/uniprot/P45478", "type": "external" } ], "mass": 34142.0, "length": 306, "protein_name": "Palmitoyl-protein thioesterase 1", "gene_name": "PPT1", "organism": "Bovine", "refseq_name": "palmitoyl-protein thioesterase 1 precursor", "refseq_ac": [ { "id": "NP_776579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776579", "type": "external" } ], "gene_names_uniprotkb": "PPT1; CLN1; PPT", "gene_names_refseq": "CLN1; PPT1", "protein_names_uniprotkb": "Palmitoyl-protein thioesterase 1; 3.1.2.22; 3.1.2.2; PPT-1; Palmitoyl-protein hydrolase 1", "protein_names_refseq": "PPT-1; palmitoyl protein thioesterase; palmitoyl-protein hydrolase 1; palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile); palmitoyl-protein thioesterase 1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281421)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10781062;30573663;7916016;8663305", "class_list": "", "function": "Has thioesterase activity against fatty acid thioesters with 14 -18 carbons, including palmitoyl-CoA, S-palmitoyl-N-acetylcysteamine, and palmitoylated proteins (PubMed:7916016). In contrast to PPT2, PPT1 can hydrolyze palmitoylated proteins and palmitoylcysteine (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A7YWB2", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" } ], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0120146 sulfatide binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0031579 membrane raft organization;GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0015031 protein transport;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P45478-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46065-1", "uniprot_id": [ { "id": "GUC1A_BOVIN", "url": "https://www.uniprot.org/uniprot/P46065", "type": "external" } ], "mass": 23510.0, "length": 205, "protein_name": "Guanylyl cyclase-activating protein 1", "gene_name": "GUCA1A", "organism": "Bovine", "refseq_name": "guanylyl cyclase-activating protein 1", "refseq_ac": [ { "id": "NP_776971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776971", "type": "external" } ], "gene_names_uniprotkb": "GUCA1A; GCAP1; GUCA1", "gene_names_refseq": "GUCA1A", "protein_names_uniprotkb": "Guanylyl cyclase-activating protein 1; GCAP 1; Guanylate cyclase activator 1A", "protein_names_refseq": "GCAP 1; guanylate cyclase activator 1A (retina); guanylyl cyclase-activating protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282243); (R-BTA-2514859)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10821676;16793776;23815670;26703466;29513743;7520254;8626484;9620085;9651312", "class_list": "", "function": "Data suggest that GCAP1 (Mg2+ vs. Ca2+) exhibits conformational changes in Ca2+ switch helix that are important in activation of RetGC1 (photoreceptor guanylate cyclase); myristoylation of GCAP1 is important as well in attaining activator conformation., [RefSeq, PubMed]; Data suggest that dimerization domain of GUCY2D operates as a calcium-sensitive regulatory module; GUCY2D requires correct conformation of monomer-monomer interface for interaction with guanylate cyclase activating proteins (GCAP1; GCAP2)., [RefSeq, PubMed]; EPR double electron-electron resonance and site-directed mutagenesis analysis determined an atomic resolution structural model of a GCAP1 dimer. It has intermolecular hydrophobic contacts involving the side chain atoms of H19, Y22, F73 and V77. Mutating any of these at the dimer interface abolished dimerization. Dimerization may affect compartmentalization of GCAP1 in the photoreceptors and/or affect cyclase regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Presence of bound magnesium (Mg2+) in guanylate cyclase activator protein GCAP-1 is essential for its ability to stimulate retinal guanylyl cyclase., [RefSeq, PubMed]; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:26703466, PubMed:7520254, PubMed:8626484, PubMed:9651312). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (PubMed:7520254, PubMed:8626484). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030249 guanylate cyclase regulator activity;GO:0008048 calcium sensitive guanylate cyclase activator activity", "go_cellular_component": "GO:0016020 membrane;GO:0001917 photoreceptor inner segment;GO:0120199 cone photoreceptor outer segment", "go_biological_process": "GO:0031284 positive regulation of guanylate cyclase activity;GO:0071277 cellular response to calcium ion;GO:0007601 visual perception;GO:0009966 regulation of signal transduction;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P46065-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46193-1", "uniprot_id": [ { "id": "ANXA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P46193", "type": "external" } ], "mass": 38952.0, "length": 346, "protein_name": "Annexin A1", "gene_name": "ANXA1", "organism": "Bovine", "refseq_name": "annexin A1", "refseq_ac": [ { "id": "NP_786978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786978", "type": "external" } ], "gene_names_uniprotkb": "ANXA1; ANX1", "gene_names_refseq": "ANXA1; p35", "protein_names_uniprotkb": "Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35", "protein_names_refseq": "annexin A1; annexin I; annexin-1; calpactin II; calpactin-2; chromobindin-9; lipocortin I; phospholipase A2 inhibitory protein", "tax_id": 9913, "disease": "", "pathway": " (bta:327662)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16305752;20359522;20400246;23565988;25827591;32458119;7678738;8286349", "class_list": "", "function": "Annexins A1 and A2 are proteins produced by airway epithelial cells that may prevent inflammation in the healthy lung and be relevant to development of pneumonia in stressed cattle. Publication Status: Online-Only, [RefSeq, PubMed]; Because annexins I and II are abundant and have functions important to the maintenance of placentation, the down-regulation of the annexin genes in the cultured NT (nuclear transfer)trophectoderm may be related to the frequent failures of NT pregnancies., [RefSeq, PubMed]; Calves that later developed pneumonia had significantly lower levels of annexin A1 and annexin A2, which are potential biomarkers of increased susceptibility to pneumonia in recently weaned and transported feedlot cattle. Publication Status: Online-Only, [RefSeq, PubMed]; Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2., [UniProtKB, UniProtKB]; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T cells. Promotes the differentiation of T cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). In the context of antitumor immunity, interacts with FPR1 on dendritic cells allowing for tumor-associated antigens uptake and cross-presentation to T cells to mount an antitumor specific T cell response., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Ubiquitination of annexin A1 may play an important role in mutagenesis, an initial step of cell transformation., [RefSeq, PubMed]; WISP1 promotes bovine MDSC differentiation via recruitment of ANXA1 for the regulation of the TGF-beta signalling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBF5;Q58DU6", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0019834 phospholipase A2 inhibitor activity;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0045087 innate immune response;GO:0046883 regulation of hormone secretion;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P46193-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51866-1", "uniprot_id": [ { "id": "PECA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P51866", "type": "external" } ], "mass": 82586.0, "length": 739, "protein_name": "Platelet endothelial cell adhesion molecule", "gene_name": "PECAM1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PECAM1", "gene_names_refseq": "", "protein_names_uniprotkb": "Platelet endothelial cell adhesion molecule; PECAM-1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "12972546;8558001", "class_list": "", "function": "Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-689 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0006955 immune response;GO:0007155 cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0071260 cellular response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51866-1", "record_type": "protein", "filter_code": "0000000.0100100.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52505-1", "uniprot_id": [ { "id": "ACPM_BOVIN", "url": "https://www.uniprot.org/uniprot/P52505", "type": "external" } ], "mass": 17402.0, "length": 156, "protein_name": "Acyl carrier protein, mitochondrial", "gene_name": "NDUFAB1", "organism": "Bovine", "refseq_name": "acyl carrier protein, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001035578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035578", "type": "external" } ], "gene_names_uniprotkb": "NDUFAB1", "gene_names_refseq": "NDUFAB1; SDAP", "protein_names_uniprotkb": "Acyl carrier protein, mitochondrial; ACP; CI-SDAP; NADH-ubiquinone oxidoreductase 9.6 kDa subunit", "protein_names_refseq": "ACP; CI-SDAP; NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa; NADH-ubiquinone oxidoreductase 9.6 kDa subunit; acyl carrier protein, mitochondrial precursor; acyl carrier protein, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:327702)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10852722;16109413;18721790;1907568", "class_list": "", "function": "Carrier of the growing fatty acid chain in fatty acid biosynthesis (PubMed:1907568). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:10852722, PubMed:18721790, PubMed:1907568). Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Data report that SDAP is found in the soluble (matrix) fraction of bovine heart mitochondria and is therefore available to serve as an acyl carrier protein to carry the intermediates of type II fatty acid synthesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T150", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0016491 oxidoreductase activity;GO:0000035 acyl binding;GO:0000036 acyl carrier activity;GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0044571 [2Fe-2S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P52505-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54131-1", "uniprot_id": [ { "id": "ACHA7_BOVIN", "url": "https://www.uniprot.org/uniprot/P54131", "type": "external" } ], "mass": 56003.0, "length": 499, "protein_name": "Neuronal acetylcholine receptor subunit alpha-7", "gene_name": "CHRNA7", "organism": "Bovine", "refseq_name": "neuronal acetylcholine receptor subunit alpha-7 precursor", "refseq_ac": [ { "id": "NP_776940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776940", "type": "external" } ], "gene_names_uniprotkb": "CHRNA7", "gene_names_refseq": "CHRNA7; nAChR7", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-7; Nicotinic acetylcholine receptor subunit alpha-7; nAChR7", "protein_names_refseq": "alpha 7 nicotinic acetylcholine receptor; cholinergic receptor, nicotinic, alpha polypeptide 7; neuronal acetylcholine receptor subunit alpha-7 precursor; neuronal acetylcholine receptor subunit alpha-7; nicotinic acetylcholine receptor subunit alpha-7", "tax_id": 9913, "disease": "", "pathway": " (bta:282178)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12438113;15611071;16129734;19063861;20043866;20932358;21420959;21729697;21790604;7620615", "class_list": "", "function": "A network of interactions formed by residues Lys-46, Asp-128, Asp-135, Asp-266, and possibly others appears to link agonist binding to channel gating, [RefSeq, PubMed]; Bovine chromaffin cells have an alpha3alpha7beta4 nicotinic receptor, [RefSeq, PubMed]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA7 forms homopentameric neuronal acetylcholine receptors abundantly expressed in the central nervous system, characterized by fast desensitization and high calcium permeability. Also forms heteropentamers with CHRNB2, mainly expressed in basal forebrain cholinergic neurons. Involved in the modulation of calcium-dependent signaling pathways and influences the release of neurotransmitters, including dopamine, glutamate and GABA. Also expressed in non-neuronal cells such as immune cells like lymphocytes, monocytes and macrophages. In T cells, activation induces metabotropic signaling that results in an increase of intracellular Ca2+ concentrations, independent of ionotropic receptor functions. In macrophages, required for acetylcholine-mediated inhibition of TNF and other inflammatory cytokine release. Once activated by acetylcholine, nicotine or other agonists, selectively inhibits production of pro-inflammatory cytokines while leaving anti-inflammatory cytokines undisturbed. Stimulates the cholinergic anti-inflammatory pathway, controlling inflammation by inhibiting NFKB nuclear translocation and activating the JAK2-STAT3 pathway, independently of ion channel activity. Also expressed in the urothelium where it modulates reflex bladder activity by increasing intracellular calcium through internal stores and decreasing basal ATP release (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Cultured bovine retinal pigment epitheliumcells expressed nicotinic receptors containing alpha7 subunit, [RefSeq, PubMed]; Data show that basic residues at positions 208 and 210 are necessary for the assembly of alpha7 receptors., [RefSeq, PubMed]; Deletion of a small cytoplasmic fragment close to the fourth transmembrane segment of the nicotinic alpha7 receptor (Glu437 to Arg447) abolished membrane expression, [RefSeq, PubMed]; Involvement of Lys145 in the early steps of channel activation by acetylcholine, [RefSeq, PubMed]; Loop 9 has a different role in the function of homomeric and heteromeric receptors., [RefSeq, PubMed]; Slowly desensitizing mutant alpha7L248T could be an interesting tool for the study of channel activation in alpha7 receptors, [RefSeq, PubMed]; We conclude that residues in the M2 segment and flanking regions contribute to the unusual properties of the CHRNA7 receptor, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0015643 toxic substance binding;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0030425 dendrite;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007271 synaptic transmission, cholinergic;GO:0008284 positive regulation of cell population proliferation;GO:0035094 response to nicotine;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P54131-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55203-1", "uniprot_id": [ { "id": "GUC2D_BOVIN", "url": "https://www.uniprot.org/uniprot/P55203", "type": "external" } ], "mass": 120369.0, "length": 1110, "protein_name": "Retinal guanylyl cyclase 1", "gene_name": "GUCY2D", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GUCY2D; GUC2D", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinal guanylyl cyclase 1; 4.6.1.2; GC-E; Guanylate cyclase 2D, retinal; Guanylate cyclase E; RETGC-1; ROS-GC; Rod outer segment membrane guanylate cyclase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "7916565;8102054;9256080", "class_list": "", "function": "Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:8102054). May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O02809", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042622 photoreceptor outer segment membrane;GO:0120200 rod photoreceptor outer segment", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0007168 receptor guanylyl cyclase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P55203-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56560-1", "uniprot_id": [ { "id": "AOFB_BOVIN", "url": "https://www.uniprot.org/uniprot/P56560", "type": "external" } ], "mass": 58421.0, "length": 520, "protein_name": "Amine oxidase [flavin-containing] B", "gene_name": "MAOB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MAOB", "gene_names_refseq": "", "protein_names_uniprotkb": "Amine oxidase [flavin-containing] B; 1.4.3.21; 1.4.3.4; MAO-B; Monoamine oxidase type B", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:338445)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11049757;2719656;2764901;8003474", "class_list": "", "function": "Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:8003474). Preferentially degrades benzylamine and phenylethylamine (PubMed:8003474)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5K2;Q864W3", "ec_number_list": [ { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "1.4.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.21", "type": "external" }, { "id": "1.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.4", "type": "external" } ], "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0042428 serotonin metabolic process;GO:0019607 phenylethylamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P56560-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56658-1", "uniprot_id": [ { "id": "ADA_BOVIN", "url": "https://www.uniprot.org/uniprot/P56658", "type": "external" } ], "mass": 40919.0, "length": 363, "protein_name": "Adenosine deaminase", "gene_name": "ADA", "organism": "Bovine", "refseq_name": "adenosine deaminase", "refseq_ac": [ { "id": "NP_776312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776312", "type": "external" } ], "gene_names_uniprotkb": "ADA", "gene_names_refseq": "ADA", "protein_names_uniprotkb": "Adenosine deaminase; 3.5.4.4; Adenosine aminohydrolase", "protein_names_refseq": "adenosine aminohydrolase; adenosine deaminase", "tax_id": 9913, "disease": "", "pathway": " (bta:280712)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11067872;12554940;14709046;15139750;15213224;15239652;15695814;16033254;16060665;17536804;18549808;18774942;23240012;28103965;28504100;8877857", "class_list": "", "function": "Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (By similarity). Plays an important role in purine metabolism and in adenosine homeostasis (By similarity). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (By similarity). Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (PubMed:23240012). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (By similarity). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase, [RefSeq, PubMed]; Data demonstrate that dipeptidyl peptidase II can form a complex with adenosine deaminase, but with one order of magnitude higher dissociation constant than that of DPPIV., [RefSeq, PubMed]; It was concluded that oxidative stress occurs in cattle experimentally infected by F. hepatica, mainly due to excessive ROS production in the course of fasciolosis, contributing to hepatic damage, and that increased in hepatic adenosine deaminase (ADA) activity may contribute to the inflammatory process., [RefSeq, PubMed]; Study concludes that dictyocaulosis alters NTPDase, 5'-nucleotidase, and ADA activities of cow naturally infected by the parasite Dictyocaulus viviparus, in consequence the enzymes act as inflammatory markers, [RefSeq, PubMed]; The transition-state structures of PfADA, HsADA, and bovine ADA (BtADA) solved using competitive kinetic isotope effects (KIE) and density functional calculations, [RefSeq, PubMed]; This is the first report that an inhibitor molecule (EHNA) with a nucleoside framework binds to the open form of ADA and the first observation of conformational change of ADA in the crystalline state., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9MYY1", "ec_number_list": [ { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" } ], "go_molecular_function": "GO:0004000 adenosine deaminase activity;GO:0008270 zinc ion binding;GO:0046936 2'-deoxyadenosine deaminase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005764 lysosome;GO:0009897 external side of plasma membrane;GO:0060205 cytoplasmic vesicle lumen;GO:0070161 anchoring junction", "go_biological_process": "GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0006154 adenosine catabolic process;GO:0007155 cell adhesion;GO:0009117 nucleotide metabolic process;GO:0046103 inosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P56658-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56965-1", "uniprot_id": [ { "id": "DDAH1_BOVIN", "url": "https://www.uniprot.org/uniprot/P56965", "type": "external" } ], "mass": 31289.0, "length": 285, "protein_name": "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1", "gene_name": "DDAH1", "organism": "Bovine", "refseq_name": "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1", "refseq_ac": [ { "id": "NP_001095671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095671", "type": "external" } ], "gene_names_uniprotkb": "DDAH1", "gene_names_refseq": "DDAH1", "protein_names_uniprotkb": "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; 3.5.3.18; DDAH-1; DDAHI; Dimethylargininase-1; Dimethylarginine dimethylaminohydrolase 1", "protein_names_refseq": "DDAH-1; DDAHI; N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; dimethylargininase-1", "tax_id": 9913, "disease": "", "pathway": " (bta:537391); (R-BTA-203615)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11546769;12441345;16698551;17881609;19820234;8849684;9537995", "class_list": "", "function": "DDAH-1 and DDAH-2 manifest their effects through different mechanisms, the former of which is largely ADMA-dependent and the latter ADMA-independent., [RefSeq, PubMed]; Demonstrate a critical role for DDAH-1 and endogenous methylarginines in the pathogenesis of endothelial dysfunction., [RefSeq, PubMed]; Dimethylargininase-1 inhibited upon specific Cys-S-nitrosylation., [RefSeq, PubMed]; High-resolution crystal structures of DDAH isoform 1 was presented., [RefSeq, PubMed]; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QQU7;P81020", "ec_number_list": [ { "id": "3.5.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.18", "type": "external" } ], "go_molecular_function": "GO:0016403 dimethylargininase activity;GO:0008270 zinc ion binding;GO:0016597 amino acid binding;GO:0030235 nitric-oxide synthase regulator activity", "go_cellular_component": "", "go_biological_process": "GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0006809 nitric oxide biosynthetic process;GO:0000052 citrulline metabolic process;GO:0006525 arginine metabolic process;GO:0017014 protein nitrosylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P56965-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58874-1", "uniprot_id": [ { "id": "OPT_BOVIN", "url": "https://www.uniprot.org/uniprot/P58874", "type": "external" } ], "mass": 35731.0, "length": 321, "protein_name": "Opticin", "gene_name": "OPTC", "organism": "Bovine", "refseq_name": "opticin precursor", "refseq_ac": [ { "id": "NP_991339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991339", "type": "external" } ], "gene_names_uniprotkb": "OPTC; OPT", "gene_names_refseq": "OPTC; SLRP", "protein_names_uniprotkb": "Opticin; Oculoglycan", "protein_names_refseq": "oculoglycan; opticin precursor; small leucine-rich repeat protein", "tax_id": 9913, "disease": "", "pathway": " (bta:404034); (R-BTA-1474228)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10636917;12951322;18164633", "class_list": "", "function": "Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (PubMed:10636917, PubMed:12951322). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Opticin is a stable dimer in solution [OPTC, opticin], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P83285;Q6X8P9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0060348 bone development;GO:0061975 articular cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P58874-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61823-1", "uniprot_id": [ { "id": "RNAS1_BOVIN", "url": "https://www.uniprot.org/uniprot/P61823", "type": "external" } ], "mass": 16461.0, "length": 150, "protein_name": "Ribonuclease pancreatic", "gene_name": "RNASE1", "organism": "Bovine", "refseq_name": "ribonuclease pancreatic precursor", "refseq_ac": [ { "id": "NP_001014408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014408", "type": "external" } ], "gene_names_uniprotkb": "RNASE1; RNS1", "gene_names_refseq": "LOC282340; RAC2; RNASE1; RNS1", "protein_names_uniprotkb": "Ribonuclease pancreatic; 4.6.1.18; RNase 1; RNase A", "protein_names_refseq": "RNase 1; RNase A; ribonuclease A (pancreatic); ribonuclease A C2; ribonuclease pancreatic precursor; ribonuclease pancreatic", "tax_id": 9913, "disease": "", "pathway": " (bta:282340)", "pathway_count": 1, "publication_count": 34, "publication_id_list": "10222001;10820257;11087402;11238647;11305910;11513604;11742124;11838679;13989651;14235531;14342316;1841699;19358553;2265605;22905393;23238807;23381689;23382559;23662732;24292629;2775743;2776756;2838818;3401445;3961503;4030761;4835726;5460889;5801478;6276380;7479688;7954510;8587129;9154942", "class_list": "", "function": "Effect of D-amino acids on the functional activity and conformational stability of ribonuclease-A, [RefSeq, PubMed]; Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA., [UniProtKB, PubMed]; Investigation of structure/stability of native pancreatic RNase A compared to specific analogs: Results suggest that a reverse turn (Asn113-Pro114) exhibits great control over unfolding, conformational stability, and enzymatic activity of RNase A., [RefSeq, PubMed]; Overexpression of bovine RNase in Toll-like receptor (TLR)7 transgenic mice results in reduction in splenomegaly, reduced numbers of activated B and T cells, fewer immune deposits in the kidney, reduced liver inflammation, and increased survival., [RefSeq, PubMed]; The initials steps of the molecular mechanism of Urea-RNase A interaction passes through the establishment of a three center four electron adduct., [RefSeq, PubMed]; Thermal unfolding of ribonuclease A (RNase) was analyzed in various osmolyte solutions of glycine, proline, sarcosine, N,N-dimethylglycine, betaine, myo-inositol, taurine, and trimethylamine-N-oxide (TMAO)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 11, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 4, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 23, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6QPW8;P00656;Q9TSF2", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004540 RNA nuclease activity;GO:0004522 ribonuclease A activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 6.0, "record_id": "P61823-1", "record_type": "protein", "filter_code": "0000000.0110101.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62894-1", "uniprot_id": [ { "id": "CYC_BOVIN", "url": "https://www.uniprot.org/uniprot/P62894", "type": "external" } ], "mass": 11704.0, "length": 105, "protein_name": "Cytochrome c", "gene_name": "CYCS", "organism": "Bovine", "refseq_name": "cytochrome c", "refseq_ac": [ { "id": "NP_001039526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039526", "type": "external" } ], "gene_names_uniprotkb": "CYCS; CYC", "gene_names_refseq": "CYCS; cytc", "protein_names_uniprotkb": "Cytochrome c", "protein_names_refseq": "cytochrome c", "tax_id": 9913, "disease": "", "pathway": " (bta:100847700); (bta:510767); (R-BTA-111457); (R-BTA-111458); (R-BTA-111459); (R-BTA-111461); (R-BTA-2151201); (R-BTA-3299685); (R-BTA-5620971); (R-BTA-5628897); (R-BTA-611105); (R-BTA-9627069); (R-BTA-9707564)", "pathway_count": 13, "publication_count": 10, "publication_id_list": "16866357;17634981;18471988;18540683;21320451;21974717;22091532;28405769;34087710;5933874", "class_list": "", "function": "Data using ribose 5-P suggest that glycation of cyt c (at lysines in ATP binding site) results in cyto c being less able to transfer electrons to cytochrome oxidase and in reduced affinity of cyt c for cardiolipin-containing liposomes., [RefSeq, PubMed]; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain., [UniProtKB]; It was found from temporal changes of the anti-Stokes Ultraviolet resonance Raman intensities that the energy flow from the heme to Trp59 and the energy release from Trp59 took place with the time constants of 1-3 and ~8 ps, respectively. Erratum:[J Phys Chem B. 2014 May 29;118(21):5797], [RefSeq, PubMed]; Peroxidase activity shown by cardiolipin-bound cytochrome c is indicative of a less packed protein tertiary conformation in the complex, [RefSeq, PubMed]; Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity)., [UniProtKB]; Structural evaluation of cytochrome c by Raman spectroscopy and its relationship with apoptosis and protein degradation in postmortem bovine muscle., [RefSeq, PubMed]; The presence of structural collective motions on a picosecond timescale for the heme protein, cytochrome c, as a function of oxidation and hydration, was investigated., [RefSeq, PubMed]; This study determines the apoptosis process mediated by cytochrome c after its release from mitochondria and the factors that affect the activation processes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P00006;Q2KJD4", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006915 apoptotic process;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P62894-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63026-1", "uniprot_id": [ { "id": "VAMP2_BOVIN", "url": "https://www.uniprot.org/uniprot/P63026", "type": "external" } ], "mass": 12649.0, "length": 116, "protein_name": "Vesicle-associated membrane protein 2", "gene_name": "VAMP2", "organism": "Bovine", "refseq_name": "vesicle-associated membrane protein 2", "refseq_ac": [ { "id": "NP_776908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776908", "type": "external" } ], "gene_names_uniprotkb": "VAMP2; SYB2", "gene_names_refseq": "VAMP2", "protein_names_uniprotkb": "Vesicle-associated membrane protein 2; Synaptobrevin-2; VAMP-2", "protein_names_refseq": "VAMP-2; synaptobrevin-2; vesicle-associated membrane protein 2 (synaptobrevin 2); vesicle-associated membrane protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282116); (R-BTA-181429); (R-BTA-181430); (R-BTA-199992); (R-BTA-210500); (R-BTA-212676); (R-BTA-264642); (R-BTA-432720); (R-BTA-432722); (R-BTA-449836); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-888590); (R-BTA-9609523)", "pathway_count": 14, "publication_count": 6, "publication_id_list": "14563208;18716205;21926345;2560644;8365494;8455717", "class_list": "", "function": "Lengthening juxtamembrane region of synaptobrevin-2 severely reduced occurrence of rapid single events, leaving slow ones unchanged. It also impaired increase in fast-fusion mode that normally follows elevation of intracellular Ca2+ levels., [RefSeq, PubMed]; SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:8455717). VAMP2 is a v-SNARE assembling into a SNARE complex with the t-SNAREs SNAP25 and STX1A to mediate the fusion of synaptic vesicles with the presynaptic plasma membrane in neurotransmitter release (By similarity). Also functions in compensatory endocytosis for synaptic vesicle recycling. In adipocytes, it is involved in the insulin-dependent exocytosis of GLUT4 storage vesicles (By similarity). Independently of its SNARE activity, it could modulate the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; VAMP-2 is critical to lysosome fusion in membrane raft clustering, and this VAMP-2-mediated lysosome-MR signalosomes contribute to redox regulation of coronary endothelial function., [RefSeq, PubMed]; VAMP2 is restricted from forming the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex in chromaffin granules from adrenal medullae to the same degree as in brain-purified synaptic vesicles., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P19065;Q9TRF2", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031982 vesicle;GO:0005901 caveola;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:1902259 regulation of delayed rectifier potassium channel activity;GO:0007165 signal transduction;GO:0042311 vasodilation;GO:0017004 cytochrome complex assembly;GO:0035493 SNARE complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P63026-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63212-1", "uniprot_id": [ { "id": "GBG2_BOVIN", "url": "https://www.uniprot.org/uniprot/P63212", "type": "external" } ], "mass": 7850.0, "length": 71, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2", "gene_name": "GNG2", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2", "refseq_ac": [ { "id": "NP_776497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776497", "type": "external" } ], "gene_names_uniprotkb": "GNG2", "gene_names_refseq": "GNG2; HG3F1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; G gamma-I", "protein_names_refseq": "g gamma-I; guanine nucleotide binding protein (G protein), gamma 2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; heterotrimeric guanine nucleotide-binding protein 3F1", "tax_id": 9913, "disease": "", "pathway": " (bta:281203); (R-BTA-1296041); (R-BTA-202040); (R-BTA-381676); (R-BTA-392170); (R-BTA-392451); (R-BTA-392851); (R-BTA-400042); (R-BTA-4086398); (R-BTA-416476); (R-BTA-416482); (R-BTA-418217); (R-BTA-418555); (R-BTA-418592); (R-BTA-418594); (R-BTA-418597); (R-BTA-420092); (R-BTA-428930); (R-BTA-432040); (R-BTA-456926); (R-BTA-500657); (R-BTA-6814122); (R-BTA-8964315); (R-BTA-8964616); (R-BTA-9009391); (R-BTA-9856530); (R-BTA-997272)", "pathway_count": 27, "publication_count": 7, "publication_id_list": "12764189;1903391;2499046;2506169;7626050;8439334;8521505", "class_list": "", "function": "Determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits, [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P16874;Q2KI31;Q61013;Q9TS47", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0071380 cellular response to prostaglandin E stimulus;GO:0071870 cellular response to catecholamine stimulus;GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P63212-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63258-1", "uniprot_id": [ { "id": "ACTG_BOVIN", "url": "https://www.uniprot.org/uniprot/P63258", "type": "external" } ], "mass": 41793.0, "length": 375, "protein_name": "Actin, cytoplasmic 2", "gene_name": "ACTG1", "organism": "Bovine", "refseq_name": "actin, cytoplasmic 2", "refseq_ac": [ { "id": "NP_001028790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028790", "type": "external" } ], "gene_names_uniprotkb": "ACTG1; ACTG", "gene_names_refseq": "ACTG1", "protein_names_uniprotkb": "Actin, cytoplasmic 2; 3.6.4.-; Gamma-actin", "protein_names_refseq": "actin, cytoplasmic 2; gamma-actin", "tax_id": 9913, "disease": "", "pathway": " (bta:404122); (R-BTA-114608); (R-BTA-190873); (R-BTA-196025); (R-BTA-2029482); (R-BTA-3928662); (R-BTA-418990); (R-BTA-4420097); (R-BTA-446353); (R-BTA-5250924); (R-BTA-5626467); (R-BTA-5663213); (R-BTA-5663220); (R-BTA-5674135); (R-BTA-5689603); (R-BTA-5696394); (R-BTA-8856828); (R-BTA-9035034); (R-BTA-9764561); (R-BTA-9913351); (R-BTA-9933937); (R-BTA-9933939); (R-BTA-9933946); (R-BTA-9933947); (R-BTA-9934037); (R-BTA-9953170); (R-BTA-9958825)", "pathway_count": 27, "publication_count": 3, "publication_id_list": "213279;23924371;28929980", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data indicate that the complex formation of actin by thymosin beta4 is more likely to be flexible than rigid and is localized along the subdomains 1 to 3 of actin., [RefSeq, PubMed]; Data show that the level of actin/PLC-zeta interaction was twice as high in G-actin that reflected an increase in affinity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QL78;P02571;P14104;P99022;Q3SZC9", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0019901 protein kinase binding;GO:0098973 structural constituent of postsynaptic actin cytoskeleton", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0048870 cell motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P63258-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68138-1", "uniprot_id": [ { "id": "ACTS_BOVIN", "url": "https://www.uniprot.org/uniprot/P68138", "type": "external" } ], "mass": 42051.0, "length": 377, "protein_name": "Actin, alpha skeletal muscle", "gene_name": "ACTA1", "organism": "Bovine", "refseq_name": "actin, alpha skeletal muscle", "refseq_ac": [ { "id": "NP_776650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776650", "type": "external" } ], "gene_names_uniprotkb": "ACTA1; ACTA", "gene_names_refseq": "ACTA1", "protein_names_uniprotkb": "Actin, alpha skeletal muscle; 3.6.4.-; Alpha-actin-1", "protein_names_refseq": "actin, alpha skeletal muscle; alpha-actin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:281592); (R-BTA-390522); (R-BTA-9764561); (R-BTA-9913351); (R-BTA-9958825)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "499690;7626220", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, 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"type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0030240 skeletal muscle thin filament assembly;GO:0048741 skeletal muscle fiber development;GO:0090131 mesenchyme migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P68138-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68401-1", "uniprot_id": [ { "id": "PA1B2_BOVIN", "url": "https://www.uniprot.org/uniprot/P68401", "type": "external" } ], "mass": 25569.0, "length": 229, "protein_name": "Platelet-activating factor acetylhydrolase IB subunit alpha2", "gene_name": "PAFAH1B2P68402", "organism": "Bovine", "refseq_name": "platelet-activating factor acetylhydrolase IB subunit alpha2", "refseq_ac": [ { "id": "NP_777089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777089", "type": "external" } ], "gene_names_uniprotkb": "PAFAH1B2P68402; PAFAHB", "gene_names_refseq": "PAFAH1B2P68402; PAFAH1B2", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase IB subunit alpha2; 3.1.1.47; PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH subunit beta", "protein_names_refseq": "PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH subunit beta; platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa); platelet-activating factor acetylhydrolase IB subunit alpha2; platelet-activating factor acetylhydrolase IB subunit beta", "tax_id": 9913, "disease": "", "pathway": " (bta:282514); (R-BTA-6798695); (R-BTA-6811436)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10542206;11522926;8537406", "class_list": "", "function": "Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF (PubMed:10542206). The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition (PubMed:10542206). The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) (PubMed:10542206). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (PubMed:10542206). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O00687;Q29459;Q3ZBB8", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": 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"url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0047179 platelet-activating factor acetyltransferase activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0016042 lipid catabolic process;GO:0016239 positive regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P68401-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68432-1", "uniprot_id": [ { "id": "H31_BOVIN", "url": "https://www.uniprot.org/uniprot/P68432", "type": "external" } ], "mass": 15404.0, "length": 136, "protein_name": "Histone H3.1", "gene_name": "", "organism": "Bovine", "refseq_name": "histone H3", "refseq_ac": [ { "id": "NP_001361459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001361459", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "LOC115945165", "protein_names_uniprotkb": "Histone H3.1", "protein_names_refseq": "histone H3", "tax_id": 9913, "disease": "", "pathway": " (bta:107131750); (bta:115945165); (bta:115945167); (bta:115945169); (bta:115945171); (bta:517139); (bta:616800); (bta:616819); (bta:788250); (R-BTA-110330); (R-BTA-110331); (R-BTA-1266695); (R-BTA-171306); (R-BTA-201722); (R-BTA-212300); (R-BTA-2299718); (R-BTA-2559580); (R-BTA-2559582); (R-BTA-2559586); (R-BTA-3214815); (R-BTA-3214841); (R-BTA-3214842); (R-BTA-3214847); (R-BTA-3214858); (R-BTA-3247509); (R-BTA-427359); (R-BTA-427413); (R-BTA-5250924); (R-BTA-5578749); (R-BTA-5625886); (R-BTA-5693565); (R-BTA-5693571); (R-BTA-5693607); (R-BTA-68616); (R-BTA-69473); (R-BTA-73728); (R-BTA-73772); (R-BTA-8936459); (R-BTA-9018519); (R-BTA-9670095); (R-BTA-9764725); (R-BTA-983231); (R-BTA-9841922); (R-BTA-9843940); (R-BTA-9843970); (R-BTA-9909649); (R-BTA-9940951); (R-BTA-9943411); (R-BTA-9943962); (R-BTA-9970672)", "pathway_count": 50, "publication_count": 5, "publication_id_list": "10464286;1167550;4700459;4735579;4735580", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02295;P02296;P16106", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P68432-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79114-1", "uniprot_id": [ { "id": "MYO10_BOVIN", "url": "https://www.uniprot.org/uniprot/P79114", "type": "external" } ], "mass": 235839.0, "length": 2052, "protein_name": "Unconventional myosin-X", "gene_name": "MYO10", "organism": "Bovine", "refseq_name": "unconventional myosin-X", "refseq_ac": [ { "id": "NP_776819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776819", "type": "external" } ], "gene_names_uniprotkb": "MYO10", "gene_names_refseq": "MYO10", "protein_names_uniprotkb": "Unconventional myosin-X; Unconventional myosin-10", "protein_names_refseq": "unconventional myosin-10; unconventional myosin-X; unconventionnal myosin-X", "tax_id": 9913, "disease": "", "pathway": " (bta:281935)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10984435;11457842;11854753;15156152;15705568;15961399;16894163;20081229;20364131;20392702;20930142;21666676;24753602;25122759;27276269;27566544;27580874", "class_list": "", "function": "A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial Tip., [RefSeq, PubMed]; At low optical trap loads, we observed staircase-like processive movements of myosin-10 interacting with the actin filament, consisting of up to six approximately 35-nm steps per binding interaction., [RefSeq, PubMed]; Kinetic analysis of function of Myosin X as a high duty ratio motor, [RefSeq, PubMed]; Myosin X is a membrane-associated molecular motor, [RefSeq, PubMed]; Myosin X is monomeric and the band 4.1-ezrin-radixin-moesin (FERM) and pleckstrin homology (PH) domains bind to the head intramolecularly, forming an inhibited conformation. Publication Status: Online-Only, [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (By similarity). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate, which are then moved relative to actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation (By similarity). Plays a role in formation of the podosome belt in osteoclasts., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Single alpha-helices domain of MYO10 unfolds progressively as the length is increased and refolds progressively as the length is reduced., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005938 cell cortex;GO:0030027 lamellipodium;GO:0030175 filopodium;GO:0001726 ruffle", "go_biological_process": "GO:0007165 signal transduction;GO:0008360 regulation of cell shape;GO:0051489 regulation of filopodium assembly;GO:0030705 cytoskeleton-dependent intracellular transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P79114-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79345-1", "uniprot_id": [ { "id": "NPC2_BOVIN", "url": "https://www.uniprot.org/uniprot/P79345", "type": "external" } ], "mass": 16640.0, "length": 149, "protein_name": "NPC intracellular cholesterol transporter 2", "gene_name": "NPC2", "organism": "Bovine", "refseq_name": "NPC intracellular cholesterol transporter 2 precursor", "refseq_ac": [ { "id": "NP_776343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776343", "type": "external" } ], "gene_names_uniprotkb": "NPC2", "gene_names_refseq": "HE1; NPC2", "protein_names_uniprotkb": "NPC intracellular cholesterol transporter 2; EPV20; Epididymal secretory protein E1; Niemann Pick type C2 protein homolog", "protein_names_refseq": "EPV20; NPC intracellular cholesterol transporter 2 precursor; Niemann-Pick disease, type C2; epididymal secretory protein E1; niemann Pick type C2 protein homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:280815); (R-BTA-6798695); (R-BTA-8964038)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12591954;16305752;17552909;17573352;18823126;20179319;22065762;25339683;27551080;29580834;9030770", "class_list": "", "function": "Analysis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease, [RefSeq, PubMed]; BNPC2 has a loosely packed region penetrating from the surface into the hydrophobic core that forms adjacent small cavities and represents an incipient cholesterol-binding site, [RefSeq, PubMed]; Data show that the effects of the lipids on cholesterol transfer mediated by NPC2 were similar to their effect on membrane fusion induced by NPC2 and saposin-C., [RefSeq, PubMed]; Data suggest ASM (acid sphingomyelinase) activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2 (Niemann Pick protein type C2); hydrolysis of sphingomyelin by ASM may be crucial for endosomal lipid degradation/sorting., [RefSeq, PubMed]; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:17552909, PubMed:29580834). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (By similarity). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17573352). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; NPC2 plays an important role in endo/lysosomal cholesterol trafficking by markedly accelerating the rates of cholesterol transport. Rates of sterol transfer from and between membranes were increased by as much as 2 orders of magnitude by NPC2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3T091;Q58DR4", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0032367 intracellular cholesterol transport;GO:0033344 cholesterol efflux;GO:0030301 cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P79345-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80746-1", "uniprot_id": [ { "id": "ITAV_BOVIN", "url": "https://www.uniprot.org/uniprot/P80746", "type": "external" } ], "mass": 116132.0, "length": 1048, "protein_name": "Integrin alpha-V", "gene_name": "ITGAV", "organism": "Bovine", "refseq_name": "integrin alpha-V precursor", "refseq_ac": [ { "id": "NP_776792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776792", "type": "external" } ], "gene_names_uniprotkb": "ITGAV", "gene_names_refseq": "ITGAV", "protein_names_uniprotkb": "Integrin alpha-V; Vitronectin receptor subunit alpha", "protein_names_refseq": "integrin alpha V subunit; integrin alpha-V precursor; integrin alpha-V; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); vitronectin receptor subunit alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:281875)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10906183;12551988;15331710;16928957;18045932;18703797;9154926", "class_list": "", "function": "Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen., [RefSeq, PubMed]; Identified as receptor for foot-and-mouth disease virus, [RefSeq, PubMed]; Specific substitutions show that the stable binding between foot-and-mouth disease virus VP1 and integrin alphavbeta6 is dependent on a helical structure and, specifically, two leucine residues at positions +1 and RGD +4 from the RGD motif., [RefSeq, PubMed]; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). ITGAV:ITGB3 acts as a receptor for CD40LG (By similarity). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results demonstrate the critical role of the RhoA/alphavbeta5 integrin pathway in mediating Pseudomonas aeruginosa-induced lung vascular permeability., [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q0PDN6;Q9GK48;Q9MZD6", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0015026 coreceptor activity;GO:0046872 metal ion binding;GO:0001618 virus receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0034683 integrin alphav-beta3 complex;GO:0034684 integrin alphav-beta5 complex;GO:0034685 integrin alphav-beta6 complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007229 integrin-mediated signaling pathway;GO:0007160 cell-matrix adhesion;GO:0033627 cell adhesion mediated by integrin;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P80746-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81644-1", "uniprot_id": [ { "id": "APOA2_BOVIN", "url": "https://www.uniprot.org/uniprot/P81644", "type": "external" } ], "mass": 11202.0, "length": 100, "protein_name": "Apolipoprotein A-II", "gene_name": "APOA2", "organism": "Bovine", "refseq_name": "apolipoprotein A-II precursor", "refseq_ac": [ { "id": "NP_001039381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039381", "type": "external" } ], "gene_names_uniprotkb": "APOA2", "gene_names_refseq": "APOA2", "protein_names_uniprotkb": "Apolipoprotein A-II; Antimicrobial peptide BAMP-1; Apo-AII; ApoA-II; Apolipoprotein A-II(1-76); Apolipoprotein A2", "protein_names_refseq": "antimicrobial peptide BAMP-1; apo-AII; apoA-II; apolipoprotein A-II precursor; apolipoprotein A-II", "tax_id": 9913, "disease": "", "pathway": " (bta:505394); (R-BTA-381426); (R-BTA-8957275); (R-BTA-8963888); (R-BTA-8963901); (R-BTA-975634)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "11801660;16075062;24004543;26495903;9538260", "class_list": "", "function": "May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Has antimicrobial activity., [UniProtKB]; The bovine APOA2 gene may be a strong candidate gene for body traits in the cattle breeding program., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2NKV9", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0031072 heat shock protein binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0034361 very-low-density lipoprotein particle;GO:0034366 spherical high-density lipoprotein particle;GO:0042627 chylomicron", "go_biological_process": "GO:0033700 phospholipid efflux;GO:0042157 lipoprotein metabolic process;GO:0009395 phospholipid catabolic process;GO:0050995 negative regulation of lipid catabolic process;GO:0006656 phosphatidylcholine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P81644-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84080-1", "uniprot_id": [ { "id": "ARF1_BOVIN", "url": "https://www.uniprot.org/uniprot/P84080", "type": "external" } ], "mass": 20697.0, "length": 181, "protein_name": "ADP-ribosylation factor 1", "gene_name": "ARF1", "organism": "Bovine", "refseq_name": "ADP-ribosylation factor 1", "refseq_ac": [ { "id": "NP_788826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788826", "type": "external" } ], "gene_names_uniprotkb": "ARF1", "gene_names_refseq": "ARF1", "protein_names_uniprotkb": "ADP-ribosylation factor 1; 3.6.5.2", "protein_names_refseq": "ADP-ribosylation factor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:338058); (R-BTA-1660499); (R-BTA-1660514); (R-BTA-199992); (R-BTA-2132295); (R-BTA-432720); (R-BTA-432722); (R-BTA-6807878); (R-BTA-6811434); (R-BTA-6811438); (R-BTA-9845576)", "pathway_count": 11, "publication_count": 10, "publication_id_list": "11703931;12388765;14654833;17942688;18250197;20529868;24058294;3133654;8505331;9109679", "class_list": "", "function": "Binding of cargo signal peptides to AP-1 induces a conformational change in its core domain that greatly enhances its interaction with Arf-1-GTP., [RefSeq, PubMed]; Data show that AP-1 recruitment to the cell membrane was found to be dependent on myristoylated ADP-ribosylation factor (ARF1), GTP or nonhydrolyzable GTP-analogs, tyrosine signals, and small amounts of phosphoinositides., [RefSeq, PubMed]; Small GTPase involved in protein trafficking between different compartments (By similarity). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (PubMed:8505331). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (By similarity). Also plays a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The ARF1 machinery also might produce movement- and fission-promoting forces through actin polymerization., [RefSeq, PubMed]; Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D7F1;P10947;P32889;Q3SZG1", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.1.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0060292 long-term synaptic depression;GO:0097061 dendritic spine organization;GO:0016192 vesicle-mediated transport;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P84080-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00194-1", "uniprot_id": [ { "id": "CNGA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q00194", "type": "external" } ], "mass": 79602.0, "length": 690, "protein_name": "Cyclic nucleotide-gated channel alpha-1", "gene_name": "CNGA1", "organism": "Bovine", "refseq_name": "cyclic nucleotide-gated channel alpha-1", "refseq_ac": [ { "id": "NP_776703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776703", "type": "external" } ], "gene_names_uniprotkb": "CNGA1; CNCG1; CNCG", "gene_names_refseq": "CNCG1; CNGA1; CNG", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated cation channel subunit alpha; cGMP-gated cation channel alpha-1", "protein_names_refseq": "CNG channel alpha-1; CNG-1; CNG1; cGMP-gated cation channel alpha-1; cyclic nucleotide gated chanel (photoreceptor), cGMP gated 1, alpha; cyclic nucleotide gated channel (photoreceptor), cGMP gated; cyclic nucleotide gated channel alpha 1; cyclic nucleotide-gated cation channel 1; cyclic nucleotide-gated channel alpha-1; cyclic nucleotide-gated channel, photoreceptor; rod photoreceptor cGMP-gated cation channel subunit alpha; rod photoreceptor cGMP-gated channel subunit alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:281700); (R-BTA-2485179); (R-BTA-2514859)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10352032;10366613;11764791;12432397;1316156;1370452;14602825;15381690;21878911;2481236;25963832;26100907;26969165;34969975;37011209;7543681", "class_list": "", "function": "Conformation changes of CNGA1 associated with its gating function are reported. Erratum:[Nat Commun. 2017 Sep 29;8:16162. doi: 10.1038/ncomms16162. PMID: 28959942] Publication Status: Online-Only, [RefSeq, PubMed]; Data show that when Pro365 is replaced with a threonine in cyclic nucleotide gated channel alpha 1 (CNGA1), cesium Cs+ permeation is nearly abolished., [RefSeq, PubMed]; Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels., [UniProtKB, PubMed, PubMed, PubMed]; The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry, [RefSeq, PubMed]; The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods., [RefSeq, PubMed]; These results suggest that restraining the A' helix to the plasma membrane potentiates CNGA1 channel opening., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005272 sodium channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment;GO:0017071 intracellular cyclic nucleotide activated cation channel complex;GO:1902495 transmembrane transporter complex;GO:0120200 rod photoreceptor outer segment", "go_biological_process": "GO:0006816 calcium ion transport;GO:0007601 visual perception;GO:0098655 monoatomic cation transmembrane transport;GO:0006812 monoatomic cation transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q00194-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.1000000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01314-1", "uniprot_id": [ { "id": "AKT1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q01314", "type": "external" } ], "mass": 55748.0, "length": 480, "protein_name": "RAC-alpha serine/threonine-protein kinase", "gene_name": "AKT1", "organism": "Bovine", "refseq_name": "RAC-alpha serine/threonine-protein kinase", "refseq_ac": [ { "id": "NP_776411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776411", "type": "external" } ], "gene_names_uniprotkb": "AKT1; PKB", "gene_names_refseq": "AKT1; AKT", "protein_names_uniprotkb": "RAC-alpha serine/threonine-protein kinase; 2.7.11.1; PKB alpha; PKB; Protein kinase B alpha; Protein kinase B; RAC-PK-alpha", "protein_names_refseq": "PKB alpha; RAC-PK-alpha; RAC-alpha serine/threonine-protein kinase; protein kinase B alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:280991)", "pathway_count": 1, "publication_count": 34, "publication_id_list": "12200236;14588144;15501927;15808505;15824471;16183860;16373398;1718748;17210830;17763874;18071915;18161856;18397796;19428794;20163929;21525255;23482611;24895572;24925969;26409042;26515369;28133865;28337827;28710500;28922408;29310676;29473848;30196810;30473339;31208179;31212969;32630550;32846937;35142310", "class_list": "", "function": "AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (By similarity). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (By similarity). AKT also regulates the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT also regulates cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating the mTORC1 signaling pathway, and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Also regulates the mTORC1 signaling pathway by catalyzing phosphorylation of CASTOR1 and DEPDC5. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Part of a positive feedback loop of mTORC2 signaling by mediating phosphorylation of MAPKAP1/SIN1, promoting mTORC2 activation (By similarity). AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (By similarity). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor 1 (IGF1) (By similarity). AKT mediates the antiapoptotic effects of IGF1 (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (By similarity). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53. Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility. Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation. Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (By similarity). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (By similarity). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (By similarity). Acts as a negative regulator of the cGAS-STING pathway by mediating phosphorylation of CGAS during mitosis, leading to its inhibition (By similarity). Acts as a regulator of mitochondrial calcium uptake by mediating phosphorylation of MICU1 in the mitochondrial intermembrane space, impairing MICU1 maturation (By similarity). Acts as an inhibitor of tRNA methylation by mediating phosphorylation of the N-terminus of METTL1, thereby inhibiting METTL1 methyltransferase activity (By similarity). In response to LPAR1 receptor pathway activation, phosphorylates Rabin8/RAB3IP which alters its activity and phosphorylates WDR44 which induces WDR44 binding to Rab11, thereby switching Rab11 vesicular function from preciliary trafficking to endocytic recycling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling, [RefSeq, PubMed]; PI3K/Akt and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide, [RefSeq, PubMed]; The measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence. Publication Status: Online-Only, [RefSeq, PubMed]; The role of the PI3K/Akt/mTOR pathway in inflammatory regulation is independent of the activation of TLRs/NF-kappaB. Cross-talk between PI3K/Akt/mTOR and TLRs/NF-kappaB signaling pathways promote inflammation., [RefSeq, PubMed]; These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production., [RefSeq, PubMed]; Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2., [RefSeq, PubMed]; Thus, activation of STAT3 and inactivation of AKT signaling are involved in structural regression of the corpus luteum., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5ER96", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0099104 potassium channel activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005758 mitochondrial intermembrane space;GO:0005886 plasma membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1902018 negative regulation of cilium assembly;GO:0006417 regulation of translation;GO:0007399 nervous system development;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q01314-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02337-1", "uniprot_id": [ { "id": "BDH_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02337", "type": "external" } ], "mass": 38391.0, "length": 344, "protein_name": "D-beta-hydroxybutyrate dehydrogenase, mitochondrial", "gene_name": "BDH1", "organism": "Bovine", "refseq_name": "D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001029772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029772", "type": "external" } ], "gene_names_uniprotkb": "BDH1; BDH", "gene_names_refseq": "BDH1", "protein_names_uniprotkb": "D-beta-hydroxybutyrate dehydrogenase, mitochondrial; 1.1.1.30; 3-hydroxybutyrate dehydrogenase; BDH", "protein_names_refseq": "3-hydroxybutyrate dehydrogenase, type 1; BDH; D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor; D-beta-hydroxybutyrate dehydrogenase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:534090); (R-BTA-77108); (R-BTA-77111); (R-BTA-9837999)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1639787;2550053;3527172;6822516;718894", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBX3", "ec_number_list": [ { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003858 3-hydroxybutyrate dehydrogenase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0099617 matrix side of mitochondrial inner membrane", "go_biological_process": "GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q02337-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03247-1", "uniprot_id": [ { "id": "APOE_BOVIN", "url": "https://www.uniprot.org/uniprot/Q03247", "type": "external" } ], "mass": 35980.0, "length": 316, "protein_name": "Apolipoprotein E", "gene_name": "APOE", "organism": "Bovine", "refseq_name": "apolipoprotein E precursor", "refseq_ac": [ { "id": "NP_776416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776416", "type": "external" } ], "gene_names_uniprotkb": "APOE", "gene_names_refseq": "APOE", "protein_names_uniprotkb": "Apolipoprotein E; Apo-E", "protein_names_refseq": "apo-E; apolipoprotein E precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281004)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12655114;14662312;15375048;16075062;16305752;1908018;19674964;24377799;26495903;30573663;8422503", "class_list": "", "function": "APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE also has a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells., [UniProtKB, UniProtKB]; After calving the apolipoprotein B(100) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP) and apolipoprotein E messenger RNA abundance were higher in the liver, [RefSeq, PubMed]; ApoE-containing particles, which increased during the lactating stage, were not associated with HDL particles, and lipid-free forms were included in cow plasma, [RefSeq, PubMed]; Bovine apoE contents in triglyceride-rich lipoproteins are modulated by nutritional treatment and closely associated with triglyceride-rich lipoprotein metabolism, [RefSeq, PubMed]; Nonesterified fatty acids significantly inhibit the expression of ApoB100, ApoE, MTP, and LDLR, thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 4, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3T006;Q5E967", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0050750 low-density lipoprotein particle receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0034363 intermediate-density lipoprotein particle;GO:0034364 high-density lipoprotein particle;GO:0070062 extracellular exosome", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0033700 phospholipid efflux;GO:0042158 lipoprotein biosynthetic process;GO:0033344 cholesterol efflux;GO:0034380 high-density lipoprotein particle assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q03247-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07722-1", "uniprot_id": [ { "id": "PLCB4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q07722", "type": "external" } ], "mass": 117110.0, "length": 1023, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4", "gene_name": "PLCB4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PLCB4", "gene_names_refseq": "", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; 3.1.4.11; PCL-C1; PLC-beta-4; Phosphoinositide phospholipase C-beta-4; Phospholipase C-beta-4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "8327481;8389372;8407970", "class_list": "", "function": "Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G protein-coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q07721;Q07723;Q07724", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding;GO:0120548 phosphatidylinositol phospholipase C activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling;GO:0046488 phosphatidylinositol metabolic process;GO:0160135 phospholipase C-activating endothelin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q07722-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIG7-1", "uniprot_id": [ { "id": "RAB5A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIG7", "type": "external" } ], "mass": 23689.0, "length": 215, "protein_name": "Ras-related protein Rab-5A", "gene_name": "RAB5A", "organism": "Bovine", "refseq_name": "ras-related protein Rab-5A", "refseq_ac": [ { "id": "NP_001069654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069654", "type": "external" } ], "gene_names_uniprotkb": "RAB5A", "gene_names_refseq": "RAB5A", "protein_names_uniprotkb": "Ras-related protein Rab-5A; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-5A", "tax_id": 9913, "disease": "", "pathway": " (bta:539764); (R-BTA-1660499); (R-BTA-8856828); (R-BTA-8873719); (R-BTA-8876198); (R-BTA-983231)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "16476778", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:16476778). RAB5A is required for the fusion of plasma membranes and early endosomes and involved in early endocytic trafficking. Required for EEA1 recruitment to early endosomes. Recruits FERRY complex to early endosomes, where FERRY links early endosomes with a subgroup of mRNAs to enable mRNA intracellular distribution (By similarity). Recruits RABEP1/Rabaptin-5 effector to early endosomes, thereby promoting endocytic membrane fusion (By similarity). Required for EGF and transferrin endocytosis and trafficking through early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (By similarity). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0006909 phagocytosis;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0IIG7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8E7-1", "uniprot_id": [ { "id": "STRA6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8E7", "type": "external" } ], "mass": 73762.0, "length": 668, "protein_name": "Receptor for retinol uptake STRA6", "gene_name": "STRA6", "organism": "Bovine", "refseq_name": "receptor for retinol uptake STRA6", "refseq_ac": [ { "id": "NP_001069198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069198", "type": "external" } ], "gene_names_uniprotkb": "STRA6", "gene_names_refseq": "STRA6", "protein_names_uniprotkb": "Receptor for retinol uptake STRA6; Retinol-binding protein receptor STRA6; Stimulated by retinoic acid gene 6 protein homolog", "protein_names_refseq": "receptor for retinol uptake STRA6; retinol-binding protein receptor STRA6; stimulated by retinoic acid 6; stimulated by retinoic acid gene 6 homolog; stimulated by retinoic acid gene 6 protein homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:515911)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16305752;17255476;18387951;18419130;32300017", "class_list": "", "function": "Functions as a retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:17255476, PubMed:18419130). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; STRA6 was identified in retinal pigment epithelium cells as a specific membrane receptor for retinol binding protein (RBP); STRA6 binds to RBP with high affinity and has robust vitamin A uptake activity from the vitamin A-RBP complex, [RefSeq, PubMed]; Study identifies an essential functional domain in STRA6, [RefSeq, PubMed]; We found that the major protein repeatedly identified as STRA6-associated protein is calmodulin, consistent with the cryogenic electron microscopy (cryo-EM) study of zebrafish STRA6 associated with calmodulin, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5PK38", "ec_number_list": [], "go_molecular_function": "GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0034632 retinol transmembrane transporter activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0034633 retinol transport;GO:0043010 camera-type eye development;GO:0071939 vitamin A import into cell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q0V8E7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17R13-1", "uniprot_id": [ { "id": "ACK1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17R13", "type": "external" } ], "mass": 114868.0, "length": 1039, "protein_name": "Activated CDC42 kinase 1", "gene_name": "TNK2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TNK2; ACK1; ACK2", "gene_names_refseq": "", "protein_names_uniprotkb": "Activated CDC42 kinase 1; 2.7.10.2; 2.7.11.1; ACK-1; Activated CDC42 kinase 2; Tyrosine kinase non-receptor protein 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:280710)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11799118;9312079", "class_list": "", "function": "Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O02742", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0016310 phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q17R13-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27974-1", "uniprot_id": [ { "id": "AUXI_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27974", "type": "external" } ], "mass": 99512.0, "length": 910, "protein_name": "Auxilin", "gene_name": "DNAJC6", "organism": "Bovine", "refseq_name": "auxilin", "refseq_ac": [ { "id": "NP_777261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777261", "type": "external" } ], "gene_names_uniprotkb": "DNAJC6", "gene_names_refseq": "DNAJC6", "protein_names_uniprotkb": "Auxilin; 3.1.3.-; DnaJ homolog subfamily C member 6", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 6; auxilin; dnaJ homolog subfamily C member 6; putative tyrosine-protein phosphatase auxilin", "tax_id": 9913, "disease": "", "pathway": " (bta:317659)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11470803;12741832;12791276;15023062;15502813;16895969;17978091;17996706;20033059;20826345;21482805;25233425;7705342;8524399", "class_list": "", "function": "Auxilin binding produces a local change in heavy-chain contacts, creating a detectable global distortion of the clathrin coat [auxilin], [RefSeq, PubMed]; Coats assembled from recombinant clathrin are good substrates for ATP- and auxilin-dependent, Hsc70-catalyzed uncoating., [RefSeq, PubMed]; Data suggest that anionic lipids (such as phosphatidylinositol phosphates) play crucial role in localization of peripheral membrane proteins (such as auxilin-1, PTEN [phosphatase and tensin homolog], and talin-1). [review-like article], [RefSeq, PubMed]; May act as a protein phosphatase and/or a lipid phosphatase (Probable). Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking (PubMed:11470803, PubMed:8524399). Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion (PubMed:15023062, PubMed:15502813, PubMed:21482805, PubMed:7705342, PubMed:8524399). The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8 (PubMed:15023062, PubMed:17996706, PubMed:21482805, PubMed:8524399). This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex (PubMed:21482805). The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia (PubMed:21482805). Then, dissociates from the released triskelia and be recycled to initiate another cycle of HSPA8's recruitment (PubMed:21482805, PubMed:8524399). Also acts during the early steps of clathrin-coated vesicle (CCV) formation through its interaction with the GTP bound form of DNM1 (PubMed:12791276)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Results describe the recruitment dynamics of GAK and auxilin to clathrin-coated pits during endocytosis., [RefSeq, PubMed]; Structure of clathrin coat with bound Hsc70 and auxilin., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0017124 SH3 domain binding;GO:0019904 protein domain specific binding;GO:0031072 heat shock protein binding;GO:0030276 clathrin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0030136 clathrin-coated vesicle;GO:0031982 vesicle;GO:0098793 presynapse", "go_biological_process": "GO:0072583 clathrin-dependent endocytosis;GO:0046907 intracellular transport;GO:0036465 synaptic vesicle recycling;GO:0072318 clathrin coat disassembly;GO:0016191 synaptic vesicle uncoating", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q27974-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27979-1", "uniprot_id": [ { "id": "RDH5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27979", "type": "external" } ], "mass": 35037.0, "length": 318, "protein_name": "Retinol dehydrogenase 5", "gene_name": "RDH5", "organism": "Bovine", "refseq_name": "retinol dehydrogenase 5", "refseq_ac": [ { "id": "NP_776591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776591", "type": "external" } ], "gene_names_uniprotkb": "RDH5; RDH1", "gene_names_refseq": "9cRDH; P32; RDH5", "protein_names_uniprotkb": "Retinol dehydrogenase 5; 1.1.1.209; 1.1.1.315; 1.1.1.53; 11-cis RDH; 11-cis RoDH; 11-cis retinol dehydrogenase; 9-cis retinol dehydrogenase; 9cRDH; P32", "protein_names_refseq": "11-cis RDH; 11-cis RoDH; 11-cis retinol dehydrogenase; 9-cis retinol dehydrogenase; retinol dehydrogenase 5 (11-cis and 9-cis); retinol dehydrogenase 5 (11-cis/9-cis); retinol dehydrogenase 5", "tax_id": 9913, "disease": "", "pathway": " (bta:281448); (R-BTA-2453902); (R-BTA-5365859)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "19393038;7544779;7836368;9654122;9914166", "class_list": "", "function": "Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:7544779, PubMed:7836368, PubMed:9654122). Has no activity towards all-trans retinal (PubMed:9654122). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE) (By similarity). Also recognizes steroids (androsterone, androstanediol) as its substrates (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1ML51;Q28004", "ec_number_list": [ { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.357", "type": "external" }, { "id": "1.1.1.188", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.188", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.225", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0047023 androsterone dehydrogenase [NAD(P)+] activity;GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity;GO:0106429 11-cis-retinol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0042572 retinol metabolic process;GO:0007601 visual perception;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q27979-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28021-1", "uniprot_id": [ { "id": "ROCK2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28021", "type": "external" } ], "mass": 160800.0, "length": 1388, "protein_name": "Rho-associated protein kinase 2", "gene_name": "ROCK2", "organism": "Bovine", "refseq_name": "rho-associated protein kinase 2", "refseq_ac": [ { "id": "NP_776877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776877", "type": "external" } ], "gene_names_uniprotkb": "ROCK2", "gene_names_refseq": "ROCK-II; ROCK2", "protein_names_uniprotkb": "Rho-associated protein kinase 2; 2.7.11.39; ROCK-II; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; p164 ROCK-2", "protein_names_refseq": "p164 ROCK-2; rho-associated protein kinase 2; rho-associated, coiled-coil-containing protein kinase 2; rho-associated, coiled-coil-containing protein kinase II", "tax_id": 9913, "disease": "", "pathway": " (bta:282041)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10209029;10818093;10873572;12954645;15475381;16574662;8641286;8702756;9456324;9565595", "class_list": "", "function": "Nucleus-localized ROCK2 targets p300 for phosphorylation to regulate its acetyltransferase activity, [RefSeq, PubMed]; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; RhoA/Rho-kinase pathway is an important component of TGF-beta-induced effects on endothelial myosin light chain phosphorylation, cytoskeletal reorganization, and barrier integrity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0072518 Rho-dependent protein serine/threonine kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0032956 regulation of actin cytoskeleton organization;GO:0030036 actin cytoskeleton organization;GO:0007266 Rho protein signal transduction;GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q28021-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28024-1", "uniprot_id": [ { "id": "GBG12_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28024", "type": "external" } ], "mass": 8057.0, "length": 72, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12", "gene_name": "GNG12", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12", "refseq_ac": [ { "id": "NP_777210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777210", "type": "external" } ], "gene_names_uniprotkb": "GNG12; GNGT12", "gene_names_refseq": "GNG12", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; Gamma-S1", "protein_names_refseq": "gamma-S1; guanine nucleotide binding protein (G protein), gamma 12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12", "tax_id": 9913, "disease": "", "pathway": " (bta:286850); (R-BTA-1296041); (R-BTA-202040); (R-BTA-381676); (R-BTA-392170); (R-BTA-392451); (R-BTA-392851); (R-BTA-400042); (R-BTA-4086398); (R-BTA-416476); (R-BTA-416482); (R-BTA-418217); (R-BTA-418555); (R-BTA-418592); (R-BTA-418594); (R-BTA-418597); (R-BTA-420092); (R-BTA-428930); (R-BTA-432040); (R-BTA-456926); (R-BTA-500657); (R-BTA-6814122); (R-BTA-8964315); (R-BTA-8964616); (R-BTA-9009391); (R-BTA-9856530); (R-BTA-997272)", "pathway_count": 27, "publication_count": 2, "publication_id_list": "30282607;7493986", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]; Overexpressing or inhibiting GNG12 demonstrated that cell growth, casein synthesis and activation of the mTORC1 signaling pathway were all up-regulated by GNG12. Cell growth, casein synthesis and mTORC1 signaling pathway were decreased in response to Leu absence, but these decreases were partially restored by GNG12 overexpression, and those effects were partially reversed by inhibiting GNG12., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJE1", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28024-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28046-1", "uniprot_id": [ { "id": "SCIN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28046", "type": "external" } ], "mass": 80578.0, "length": 715, "protein_name": "Scinderin", "gene_name": "SCIN", "organism": "Bovine", "refseq_name": "scinderin", "refseq_ac": [ { "id": "NP_776602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776602", "type": "external" } ], "gene_names_uniprotkb": "SCIN", "gene_names_refseq": "SCIN", "protein_names_uniprotkb": "Scinderin; Adseverin; SC", "protein_names_refseq": "SC; adseverin; scinderin", "tax_id": 9913, "disease": "", "pathway": " (bta:281478)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1651929;1847925;31090208;8119933;8780652", "class_list": "", "function": "Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+) (PubMed:1651929, PubMed:1847925, PubMed:8780652). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (PubMed:8780652). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; These findings demonstrate that adseverin regulates features indicative of redifferentiation in passaged articular chondrocytes through modulation of the actin cytoskeleton., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q27948", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton;GO:0002102 podosome", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0007417 central nervous system development;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q28046-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28113-1", "uniprot_id": [ { "id": "FUT2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28113", "type": "external" } ], "mass": 39320.0, "length": 344, "protein_name": "Galactoside alpha-(1,2)-fucosyltransferase 2", "gene_name": "FUT2", "organism": "Bovine", "refseq_name": "galactoside alpha-(1,2)-fucosyltransferase 2", "refseq_ac": [ { "id": "NP_803466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803466", "type": "external" } ], "gene_names_uniprotkb": "FUT2", "gene_names_refseq": "FUT2; Se; sec1", "protein_names_uniprotkb": "Galactoside alpha-(1,2)-fucosyltransferase 2; 2.4.1.344; 2.4.1.69; Alpha(1,2)FT 2; Fucosyltransferase 2; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; Secretor factor; Se; Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2; Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2", "protein_names_refseq": "GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; alpha(1,2)FT 2; alpha(1-2) fucosyltransferase sec1; fucosyltransferase 2 (secretor status included); galactoside 2-alpha-L-fucosyltransferase 2; galactoside alpha-(1,2)-fucosyltransferase 2; secretor factor; type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2; type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2", "tax_id": 9913, "disease": "", "pathway": " (bta:281175)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10814703;20506485", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:10814703). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (By similarity). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:20506485)., [UniProtKB, PubMed, UniProtKB, PubMed]; Data show that si-RNA induced down-regulation of FUT1 and FUT2 reduced expression of fucosylated nucleolin glycoforms and their exposure at the cell surface., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.344", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.344", "type": "external" }, { "id": "2.4.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.69", "type": "external" } ], "go_molecular_function": "GO:0031127 alpha-(1,2)-fucosyltransferase activity;GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0036066 protein O-linked glycosylation via fucose", "synthesized_glycan_count": 1540, "hit_score": 0.3, "record_id": "Q28113-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28146-1", "uniprot_id": [ { "id": "NRX1A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28146", "type": "external" } ], "mass": 167939.0, "length": 1530, "protein_name": "Neurexin-1", "gene_name": "NRXN1", "organism": "Bovine", "refseq_name": "neurexin-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_776829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776829", "type": "external" } ], "gene_names_uniprotkb": "NRXN1", "gene_names_refseq": "NRXN1", "protein_names_uniprotkb": "Neurexin-1; Neurexin I-alpha; Neurexin-1-alpha", "protein_names_refseq": "neurexin-1 isoform 1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281950)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1621094;16772286;18334217;21552542;21620716;21620717;7695896;8699246", "class_list": "", "function": "Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may affect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom., [UniProtKB, UniProtKB]; Crystallographic analysis of the second LNS/LG domain from neurexin 1alpha, [RefSeq, PubMed]; Structural basis for neuroligin binding Publication Status: Online-Only, [RefSeq, PubMed]; The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function, [RefSeq, PubMed]; The structure of neurexin 1alpha reveals features promoting a role as synaptic organizer, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0097109 neuroligin family protein binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0098820 trans-synaptic protein complex", "go_biological_process": "GO:0097116 gephyrin clustering involved in postsynaptic density assembly;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q28146-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28147-1", "uniprot_id": [ { "id": "PP1R8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28147", "type": "external" } ], "mass": 38521.0, "length": 351, "protein_name": "Nuclear inhibitor of protein phosphatase 1", "gene_name": "PPP1R8", "organism": "Bovine", "refseq_name": "nuclear inhibitor of protein phosphatase 1", "refseq_ac": [ { "id": "NP_777007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777007", "type": "external" } ], "gene_names_uniprotkb": "PPP1R8; NIPP1", "gene_names_refseq": "PPP1R8", "protein_names_uniprotkb": "Nuclear inhibitor of protein phosphatase 1; NIPP-1; Protein phosphatase 1 regulatory inhibitor subunit 8", "protein_names_refseq": "NIPP-1; nuclear inhibitor of protein phosphatase 1; protein phosphatase 1, regulatory inhibitor subunit 8", "tax_id": 9913, "disease": "", "pathway": " (bta:282319)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10318819;7499293;9268347;9407077", "class_list": "", "function": "Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0003677 DNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q28147-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28165-1", "uniprot_id": [ { "id": "PABP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28165", "type": "external" } ], "mass": 32766.0, "length": 306, "protein_name": "Polyadenylate-binding protein 2", "gene_name": "PABPN1", "organism": "Bovine", "refseq_name": "polyadenylate-binding protein 2", "refseq_ac": [ { "id": "NP_776994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776994", "type": "external" } ], "gene_names_uniprotkb": "PABPN1; PAB2; PABP2", "gene_names_refseq": "PABPN1", "protein_names_uniprotkb": "Polyadenylate-binding protein 2; Nuclear poly(A)-binding protein 1; PABII; PABP-2; Poly(A)-binding protein 2; Poly(A)-binding protein II; Polyadenylate-binding nuclear protein 1", "protein_names_refseq": "PABII; PABP-2; nuclear poly(A)-binding protein 1; poly(A)-binding protein 2; poly(A)-binding protein II; polyadenylate-binding nuclear protein 1; polyadenylate-binding protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282298); (R-BTA-73856); (R-BTA-77595); (R-BTA-9770562); (R-BTA-9930044)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10224081;10481015;10688363;12637556;12853485;14627730;18495660;19509282;7479061", "class_list": "", "function": "C-terminal domain containing the methylated arginine residues is known to promote PAPBN1 self-association, and arginine methylation has been reported to inhibit self-association of an orthologous protein, [RefSeq, PubMed]; Fibril formation from trinucleotide expansion, [RefSeq, PubMed]; Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (PubMed:10481015, PubMed:7479061). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length (PubMed:12637556). Increases the affinity of poly(A) polymerase for RNA (PubMed:12637556, PubMed:12853485). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (By similarity). Binds to poly(A) and to poly(G) with high affinity (PubMed:12637556, PubMed:7479061). May protect the poly(A) tail from degradation (PubMed:7479061). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; PABPN1 measures the length of the tail and is responsible for disrupting the CPSF-poly(A) polymerase interaction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KN38", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0070063 RNA polymerase binding;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:1990904 ribonucleoprotein complex;GO:0042405 nuclear inclusion body", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006397 mRNA processing;GO:0000165 MAPK cascade;GO:0071222 cellular response to lipopolysaccharide;GO:1904247 positive regulation of polynucleotide adenylyltransferase activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q28165-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28177-1", "uniprot_id": [ { "id": "BFSP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28177", "type": "external" } ], "mass": 45950.0, "length": 415, "protein_name": "Phakinin", "gene_name": "BFSP2", "organism": "Bovine", "refseq_name": "phakinin", "refseq_ac": [ { "id": "NP_776673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776673", "type": "external" } ], "gene_names_uniprotkb": "BFSP2", "gene_names_refseq": "BFSP2; LIFL-L", "protein_names_uniprotkb": "Phakinin; 49 kDa cytoskeletal protein; Beaded filament structural protein 2; CP47; CP49; LIFL-L; Lens fiber cell beaded filament protein CP 47; Lens fiber cell beaded filament protein CP 49; Lens intermediate filament-like light", "protein_names_refseq": "49 kDa cytoskeletal protein; CP 47; CP47; CP49; beaded filament structural protein 2, phakinin; lens fiber cell beaded filament protein CP 47; lens fiber cell beaded filament protein CP 49; lens intermediate filament-like light; phakinin", "tax_id": 9913, "disease": "", "pathway": " (bta:281645)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19875662;7504675;7588880;7679620", "class_list": "", "function": "Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Plays a role in maintenance of retinal lens optical clarity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05B61", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0005882 intermediate filament", "go_biological_process": "GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q28177-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28193-1", "uniprot_id": [ { "id": "FURIN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28193", "type": "external" } ], "mass": 87251.0, "length": 797, "protein_name": "Furin", "gene_name": "FURIN", "organism": "Bovine", "refseq_name": "furin precursor", "refseq_ac": [ { "id": "NP_776561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776561", "type": "external" } ], "gene_names_uniprotkb": "FURIN; FUR; PACE", "gene_names_refseq": "FURIN; PACE", "protein_names_uniprotkb": "Furin; 3.4.21.75; Dibasic-processing enzyme; PACE; Paired basic amino acid residue-cleaving enzyme; Trans Golgi network protease furin", "protein_names_refseq": "dibasic-processing enzyme; furin precursor; furin, membrane associated receptor protein; paired basic amino acid cleaving enzyme; paired basic amino acid residue-cleaving enzyme; trans Golgi network protease furin", "tax_id": 9913, "disease": "", "pathway": " (bta:281374)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7806563", "class_list": "", "function": "Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:7806563). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0046872 metal ion binding;GO:1904399 heparan sulfate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0016486 peptide hormone processing;GO:0006465 signal peptide processing;GO:0140447 cytokine precursor processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28193-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29451-1", "uniprot_id": [ { "id": "MA2B1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29451", "type": "external" } ], "mass": 112919.0, "length": 999, "protein_name": "Lysosomal alpha-mannosidase", "gene_name": "MAN2B1", "organism": "Bovine", "refseq_name": "lysosomal alpha-mannosidase precursor", "refseq_ac": [ { "id": "NP_776986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776986", "type": "external" } ], "gene_names_uniprotkb": "MAN2B1; MANB", "gene_names_refseq": "MAN2B1; MANB", "protein_names_uniprotkb": "Lysosomal alpha-mannosidase; 3.2.1.24; Laman; Lysosomal acid alpha-mannosidase; Mannosidase alpha class 2B member 1; Mannosidase alpha-B", "protein_names_refseq": "laman; lysosomal acid alpha-mannosidase; lysosomal alpha-mannosidase precursor; lysosomal alpha-mannosidase; mannosidase alpha-B; mannosidase, alpha B, lysosomal", "tax_id": 9913, "disease": "", "pathway": " (bta:282272); (R-BTA-6798695); (R-BTA-8853383)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12634058;19393038;9208932", "class_list": "glycogene;glycosylhydrolase", "function": "A previously undetected mechanism of low-pH activation and a role in lysosomal transport, [RefSeq, PubMed]; Can hydrolyze a variety of glycan substrates containing terminal alpha-mannosidic linkages. Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues on oligosaccharides generated by N-glycoprotein degradation pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "F1MMX7;O02848;O19138", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0006013 mannose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q29451-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.1000000011000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29455-1", "uniprot_id": [ { "id": "DNJC5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29455", "type": "external" } ], "mass": 22133.0, "length": 198, "protein_name": "DnaJ homolog subfamily C member 5", "gene_name": "DNAJC5", "organism": "Bovine", "refseq_name": "dnaJ homolog subfamily C member 5", "refseq_ac": [ { "id": "NP_776958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776958", "type": "external" } ], "gene_names_uniprotkb": "DNAJC5", "gene_names_refseq": "DNAJC5", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 5; CSP; Cysteine string protein", "protein_names_refseq": "CSP; DnaJ (Hsp40) homolog, subfamily C, member 5; cysteine string protein; dnaJ homolog subfamily C member 5", "tax_id": 9913, "disease": "", "pathway": " (bta:282216); (R-BTA-6798695); (R-BTA-888590)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11604405;18596047;25800794;26198635;8631751;8702643;9395474", "class_list": "", "function": "Acts as a general chaperone in regulated exocytosis (PubMed:9395474). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VCC7;Q29456", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031594 neuromuscular junction;GO:0042470 melanosome", "go_biological_process": "GO:0006457 protein folding;GO:0098693 regulation of synaptic vesicle cycle", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q29455-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29460-1", "uniprot_id": [ { "id": "PA1B3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29460", "type": "external" } ], "mass": 25865.0, "length": 232, "protein_name": "Platelet-activating factor acetylhydrolase IB subunit alpha1", "gene_name": "PAFAH1B3", "organism": "Bovine", "refseq_name": "platelet-activating factor acetylhydrolase IB subunit alpha1", "refseq_ac": [ { "id": "NP_777090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777090", "type": "external" } ], "gene_names_uniprotkb": "PAFAH1B3; PAFAHG", "gene_names_refseq": "PAFAH1B3", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase IB subunit alpha1; 3.1.1.47; PAF acetylhydrolase 29 kDa subunit; PAF-AH 29 kDa subunit; PAF-AH subunit gamma; PAFAH subunit gamma", "protein_names_refseq": "PAF acetylhydrolase 29 kDa subunit; PAF-AH 29 kDa subunit; PAF-AH subunit gamma; PAFAH subunit gamma; platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa); platelet-activating factor acetylhydrolase IB subunit alpha1; platelet-activating factor acetylhydrolase IB subunit gamma", "tax_id": 9913, "disease": "", "pathway": " (bta:282515); (R-BTA-6811436)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10542206;30008286;8083218;8985254", "class_list": "", "function": "Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF (PubMed:10542206). The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition (PubMed:10542206). Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) (PubMed:10542206). Plays an important role during the development of brain., [UniProtKB, PubMed]; In conclusion, our results show that one of the catalytic subunits of PAFAH1B, namely PAFAH1B3, is present in bovine, oocytes and that it plays a functional role in spindle formation and meiotic progression during bovine oocyte maturation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VCF0", "ec_number_list": [ { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0047179 platelet-activating factor acetyltransferase activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q29460-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29W19-1", "uniprot_id": [ { "id": "PACA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29W19", "type": "external" } ], "mass": 19464.0, "length": 176, "protein_name": "Pituitary adenylate cyclase-activating polypeptide", "gene_name": "ADCYAP1", "organism": "Bovine", "refseq_name": "pituitary adenylate cyclase-activating polypeptide precursor", "refseq_ac": [ { "id": "NP_001040020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040020", "type": "external" } ], "gene_names_uniprotkb": "ADCYAP1; PACAP", "gene_names_refseq": "ADCYAP1; PACAP", "protein_names_uniprotkb": "Pituitary adenylate cyclase-activating polypeptide; PACAP; PRP-48", "protein_names_refseq": "adenylate cyclase activating polypeptide 1 (pituitary); pituitary adenylate cyclase-activating polypeptide precursor; pituitary adenylate cyclase-activating polypeptide", "tax_id": 9913, "disease": "", "pathway": " (bta:615187)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12438167;23800469", "class_list": "", "function": "PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1) (By similarity). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (PubMed:23800469). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). PACAP exists in two bioactive forms from proteolysis of the same precursor protein, PACAP27 and PACAP38, which differ by eleven amino acid residues in the C-terminus (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; PACAP stimulates secretoneurin release and secretogranin II gene transcription in bovine adrenochromaffin cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016521 pituitary adenylate cyclase activating polypeptide activity;GO:0005184 neuropeptide hormone activity;GO:0051428 peptide hormone receptor binding;GO:0031891 type 1 vasoactive intestinal polypeptide receptor binding;GO:0031892 type 2 vasoactive intestinal polypeptide receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0043204 perikaryon;GO:0043005 neuron projection", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0031175 neuron projection development;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q29W19-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2M2T1-1", "uniprot_id": [ { "id": "H2B1K_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2M2T1", "type": "external" } ], "mass": 13875.0, "length": 126, "protein_name": "Histone H2B type 1-K", "gene_name": "H2BC12", "organism": "Bovine", "refseq_name": "histone H2B type 1-K", "refseq_ac": [ { "id": "NP_001071531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071531", "type": "external" } ], "gene_names_uniprotkb": "H2BC12", "gene_names_refseq": "H2BC12; HIST1H2BK; HIST1H2BN", "protein_names_uniprotkb": "Histone H2B type 1-K", "protein_names_refseq": "H2B histone family, member T; histone H2B type 1-K; histone cluster 1, H2bk; histone cluster 1, H2bn", "tax_id": 9913, "disease": "", "pathway": " (bta:616627)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12777396;2713375", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2M2T1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9S0-1", "uniprot_id": [ { "id": "TBB3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9S0", "type": "external" } ], "mass": 50433.0, "length": 450, "protein_name": "Tubulin beta-3 chain", "gene_name": "TUBB3", "organism": "Bovine", "refseq_name": "tubulin beta-3 chain", "refseq_ac": [ { "id": "NP_001070595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070595", "type": "external" } ], "gene_names_uniprotkb": "TUBB3", "gene_names_refseq": "TUBB3; TUBB4", "protein_names_uniprotkb": "Tubulin beta-3 chain", "protein_names_refseq": "tubulin beta-3 chain; tubulin, beta, 3; tubulin, beta, 4", "tax_id": 9913, "disease": "", "pathway": " (bta:768070); (R-BTA-2132295); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-3371497); (R-BTA-5620924); (R-BTA-6807878); (R-BTA-6811436); (R-BTA-9646399); (R-BTA-9648025)", "pathway_count": 10, "publication_count": 4, "publication_id_list": "2052551;2207090;6504138;7704569", "class_list": "", "function": "Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (By similarity). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569). TUBB3 plays a critical role in proper axon guidance and maintenance (By similarity). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Plays a role in dorsal root ganglion axon projection towards the spinal cord (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0030027 lamellipodium;GO:0030426 growth cone;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0007411 axon guidance;GO:0038007 netrin-activated signaling pathway;GO:1990791 dorsal root ganglion development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q2T9S0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BM58-1", "uniprot_id": [ { "id": "PRAX_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BM58", "type": "external" } ], "mass": 142695.0, "length": 1349, "protein_name": "Periaxin", "gene_name": "PRX", "organism": "Bovine", "refseq_name": "periaxin isoform X2", "refseq_ac": [ { "id": "XP_003587302", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587302", "type": "external" } ], "gene_names_uniprotkb": "PRX", "gene_names_refseq": "PRX", "protein_names_uniprotkb": "Periaxin", "protein_names_refseq": "periaxin isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:520296)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14625392;19393038", "class_list": "", "function": "Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0070161 anchoring junction", "go_biological_process": "GO:0032287 peripheral nervous system myelin maintenance;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E1BM58-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8NN94-1", "uniprot_id": [ { "id": "RM34_BOVIN", "url": "https://www.uniprot.org/uniprot/A8NN94", "type": "external" } ], "mass": 10754.0, "length": 96, "protein_name": "Large ribosomal subunit protein bL34m", "gene_name": "MRPL34", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein bL34m", "refseq_ac": [ { "id": "NP_001103657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103657", "type": "external" } ], "gene_names_uniprotkb": "MRPL34", "gene_names_refseq": "L34mt; MRP-L34; MRPL34", "protein_names_uniprotkb": "Large ribosomal subunit protein bL34m; 39S ribosomal protein L34, mitochondrial; L34mt; MRP-L34", "protein_names_refseq": "39S ribosomal protein L34, mitochondrial; large ribosomal subunit protein bL34m", "tax_id": 9913, "disease": "", "pathway": " (bta:786454); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279069;16510155", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A8NN94-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00741-1", "uniprot_id": [ { "id": "FA9_BOVIN", "url": "https://www.uniprot.org/uniprot/P00741", "type": "external" } ], "mass": 52046.0, "length": 462, "protein_name": "Coagulation factor IX", "gene_name": "F9", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "F9", "gene_names_refseq": "", "protein_names_uniprotkb": "Coagulation factor IX; 3.4.21.22; Christmas factor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-159740); (R-BTA-159763); (R-BTA-159782); (R-BTA-9769735); (R-BTA-9769739); (R-BTA-9769743); (R-BTA-9935598)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "12695512;19393038;2105311;2129367;291916;3149637;6287289;6688526;6782101;6853476", "class_list": "", "function": "Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 5, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "F1MFL4", "ec_number_list": [ { "id": "3.4.21.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.22", "type": "external" }, { "id": "3.4.21.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6", "type": "external" }, { "id": "3.4.21.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.21", "type": "external" }, { "id": "4.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90", "type": "external" }, { "id": "1.14.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.16", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P00741-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZ47-1", "uniprot_id": [ { "id": "RM33_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZ47", "type": "external" } ], "mass": 7490.0, "length": 65, "protein_name": "Large ribosomal subunit protein bL33m", "gene_name": "MRPL33", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein bL33m", "refseq_ac": [ { "id": "NP_001106779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106779", "type": "external" } ], "gene_names_uniprotkb": "MRPL33", "gene_names_refseq": "L33mt; MRP-L33; MRPL33", "protein_names_uniprotkb": "Large ribosomal subunit protein bL33m; 39S ribosomal protein L33, mitochondrial; L33mt; MRP-L33", "protein_names_refseq": "39S ribosomal protein L33, mitochondrial; large ribosomal subunit protein bL33m", "tax_id": 9913, "disease": "", "pathway": " (bta:101904449); (bta:614711)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11279069;16510155", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3SZ47-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPQ5-1", "uniprot_id": [ { "id": "RM01_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPQ5", "type": "external" } ], "mass": 36657.0, "length": 325, "protein_name": "Large ribosomal subunit protein uL1m", "gene_name": "MRPL1", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein uL1m precursor", "refseq_ac": [ { "id": "NP_001095314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095314", "type": "external" } ], "gene_names_uniprotkb": "MRPL1", "gene_names_refseq": "L1mt; MRP-L1; MRPL1", "protein_names_uniprotkb": "Large ribosomal subunit protein uL1m; 39S ribosomal protein L1, mitochondrial; L1mt; MRP-L1", "protein_names_refseq": "39S ribosomal protein L1, mitochondrial; large ribosomal subunit protein uL1m precursor; large ribosomal subunit protein uL1m", "tax_id": 9913, "disease": "", "pathway": " (bta:504835); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "16510155", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome;GO:0003723 RNA binding", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:0006417 regulation of translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QPQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLP2-1", "uniprot_id": [ { "id": "SAHH3_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLP2", "type": "external" } ], "mass": 66774.0, "length": 611, "protein_name": "S-adenosylhomocysteine hydrolase-like protein 2", "gene_name": "AHCYL2", "organism": "Bovine", "refseq_name": "adenosylhomocysteinase 3", "refseq_ac": [ { "id": "NP_001094613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094613", "type": "external" } ], "gene_names_uniprotkb": "AHCYL2", "gene_names_refseq": "AHCYL2; IRBIT2", "protein_names_uniprotkb": "S-adenosylhomocysteine hydrolase-like protein 2; IP(3)Rs binding protein released with IP(3) 2; IRBIT2; Long-IRBIT", "protein_names_refseq": "IP(3)Rs binding protein released with IP(3) 2; S-adenosylhomocysteine hydrolase-like 2; adenosylhomocysteinase 3; adoHcyase 3; long-IRBIT; putative adenosylhomocysteinase 3", "tax_id": 9913, "disease": "", "pathway": " (bta:532836); (R-BTA-425381)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19393038;24472682", "class_list": "", "function": "Regulatory protein that interacts with and modulates the activity of membrane ion transporters, including the sodium-bicarbonate cotransporter SLC4A4, through phosphorylation-dependent binding (PubMed:24472682). Functions as a homolog of AHCYL1 to regulate bicarbonate transport and intracellular pH homeostasis via direct interactions rather than enzymatic activity (By similarity). On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; The cytosolic ionic conditions appropriate for AHCYL2 to function might be different from IRBIT., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0043005 neuron projection", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0033353 S-adenosylmethionine cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A6QLP2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9N0H5-1", "uniprot_id": [ { "id": "ARRC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9N0H5", "type": "external" } ], "mass": 42880.0, "length": 389, "protein_name": "Arrestin-C", "gene_name": "ARR3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ARR3", "gene_names_refseq": "", "protein_names_uniprotkb": "Arrestin-C; Cone arrestin; Retinal cone arrestin-3; X-arrestin; cArr", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281011)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10745092;25772009", "class_list": "", "function": "May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0002031 G protein-coupled receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9N0H5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01131-1", "uniprot_id": [ { "id": "LDLR_BOVIN", "url": "https://www.uniprot.org/uniprot/P01131", "type": "external" } ], "mass": 92869.0, "length": 845, "protein_name": "Low-density lipoprotein receptor", "gene_name": "LDLR", "organism": "Bovine", "refseq_name": "low-density lipoprotein receptor precursor", "refseq_ac": [ { "id": "NP_001160002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160002", "type": "external" } ], "gene_names_uniprotkb": "LDLR", "gene_names_refseq": "LDLR", "protein_names_uniprotkb": "Low-density lipoprotein receptor; LDL receptor", "protein_names_refseq": "LDL receptor; low-density lipoprotein receptor precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281276); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-8964026); (R-BTA-8964038)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "19393038;24377799;3755212;6143315;6313699;6327078", "class_list": "", "function": "Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nonesterified fatty acids significantly inhibit the expression of ApoB100, ApoE, MTP, and LDLR, thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1MZ58", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding;GO:0005509 calcium ion binding;GO:0030229 very-low-density lipoprotein particle receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0009986 cell surface", "go_biological_process": "GO:1903979 negative regulation of microglial cell activation;GO:1905167 positive regulation of lysosomal protein catabolic process;GO:0001523 retinoid metabolic process;GO:0008203 cholesterol metabolic process;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P01131-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02465-1", "uniprot_id": [ { "id": "CO1A2_BOVIN", "url": "https://www.uniprot.org/uniprot/P02465", "type": "external" } ], "mass": 129064.0, "length": 1364, "protein_name": "Collagen alpha-2(I) chain", "gene_name": "COL1A2", "organism": "Bovine", "refseq_name": "collagen alpha-2(I) chain precursor", "refseq_ac": [ { "id": "NP_776945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776945", "type": "external" } ], "gene_names_uniprotkb": "COL1A2", "gene_names_refseq": "COL1A2", "protein_names_uniprotkb": "Collagen alpha-2(I) chain; Alpha-2 type I collagen", "protein_names_refseq": "alpha-2 type I collagen; collagen 1 alpha 2 chain; collagen alpha-2(I) chain precursor; collagen alpha-2(I) chain; collagen, type I, alpha 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282188); (R-BTA-114604); (R-BTA-1650814); (R-BTA-430116)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12373276;16154140;16928957;1721846;173531;4412529;4435743;4609475;9628255", "class_list": "", "function": "Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen., [RefSeq, PubMed]; In advanced stage granulomas in Mycobacterium bovis-infected cattle, there was an increase in the expression of type I procollagen, [RefSeq, PubMed]; Type I collagen is a member of group I collagen (fibrillar forming collagen)., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 1, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A6QP13;O62649", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0005201 extracellular matrix structural constituent;GO:0002020 protease binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005584 collagen type I trimer;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001501 skeletal system development;GO:0030199 collagen fibril organization;GO:0043588 skin development;GO:0008217 regulation of blood pressure;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P02465-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00514-1", "uniprot_id": [ { "id": "KAP0_BOVIN", "url": "https://www.uniprot.org/uniprot/P00514", "type": "external" } ], "mass": 42893.0, "length": 380, "protein_name": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "gene_name": "PRKAR1A", "organism": "Bovine", "refseq_name": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "refseq_ac": [ { "id": "NP_001069826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069826", "type": "external" } ], "gene_names_uniprotkb": "PRKAR1A", "gene_names_refseq": "PRKAR1A", "protein_names_uniprotkb": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "protein_names_refseq": "cAMP-dependent protein kinase type I-alpha regulatory subunit; cAMP-dependent protein kinase, regulatory subunit alpha 1; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)", "tax_id": 9913, "disease": "", "pathway": " (bta:615074); (R-BTA-163615); (R-BTA-164378); (R-BTA-180024); (R-BTA-432040); (R-BTA-442720); (R-BTA-5610787); (R-BTA-9634597); (R-BTA-983231); (R-BTA-9856530)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "16305752;26618408;27028580;28661131;3030405;34006641;3667618;6190178;6487597;7638597", "class_list": "", "function": "Data suggest PRKAR1A contains two structurally homologous cAMP-binding domains that exhibit marked differences in dynamic profiles in activation/inhibition of Prkaca; conservation of structure does not necessarily imply conservation of dynamics. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this 'Flipback' conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit), [RefSeq, PubMed]; Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations., [RefSeq, PubMed]; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D9F4;Q17QP8", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0071377 cellular response to glucagon stimulus;GO:0046007 negative regulation of activated T cell proliferation;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P00514-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02662-1", "uniprot_id": [ { "id": "CASA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P02662", "type": "external" } ], "mass": 24529.0, "length": 214, "protein_name": "Alpha-S1-casein", "gene_name": "CSN1S1", "organism": "Bovine", "refseq_name": "alpha-S1-casein precursor", "refseq_ac": [ { "id": "NP_851372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851372", "type": "external" } ], "gene_names_uniprotkb": "CSN1S1", "gene_names_refseq": "CSN1S1; CSN1", "protein_names_uniprotkb": "Alpha-S1-casein", "protein_names_refseq": "alpha-S1-casein precursor; alpha-S1-casein; casein alpha-S1", "tax_id": 9913, "disease": "", "pathway": " (bta:282208); (R-BTA-5223345)", "pathway_count": 2, "publication_count": 32, "publication_id_list": "11174208;11678861;11945462;12170271;1299613;1343827;15541041;15858219;1658736;1710568;17228168;18992943;19454699;23755758;25200775;27065254;3022833;30580950;34019948;36307246;37604312;3838718;41018975;4331376;4797901;5064450;6328443;6897774;8836334;8841384;9512346;9600504", "class_list": "", "function": "Antioxidant peptide has 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity., [UniProtKB, UniProtKB]; Identification of genomic regions associated with alphaS1-casein phosphorylation., [RefSeq, PubMed]; Important role in the capacity of milk to transport calcium phosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Report proteomic detection of bovine alpha-S1-casein in term and preterm human colostrum., [RefSeq, PubMed]; The results give insight in phosphorylation of alpha(S1)-CN-8P and alpha(S1)-CN-9P, which seem to be regulated by a different set of genes., [RefSeq, PubMed]; There were no associations between x genotype and fertility related traits in this study., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5YK80;A8WCP1;A8WCP2;A8WCP3;A8WCP4;A8WCP5;A8WCP6;A8WCP7;A8WCP8;A8WCP9;A8WCQ0;A8WCQ1;A8WCQ2;A8WCQ3;A8WCQ4;A8WCQ5;A8WCQ6;A8WCQ7;A8WCQ8;A8WCQ9;A8WCR0;A8WCR1;A8WCR2;A8WCR3;A8WCR4;A8WCR5;A8WCR6;A8WCR7;A8WCR8;A8WCR9;A8WCS0;A8WCS1;Q28048;Q28069;Q32LE8;Q7M2U6;Q9TRH5", "ec_number_list": [], "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0005576 extracellular region", "go_biological_process": "GO:1902904 negative regulation of supramolecular fiber organization;GO:0032570 response to progesterone;GO:0050821 protein stabilization;GO:0032355 response to estradiol;GO:0060416 response to growth hormone", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P02662-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00517-1", "uniprot_id": [ { "id": "KAPCA_BOVIN", "url": "https://www.uniprot.org/uniprot/P00517", "type": "external" } ], "mass": 40620.0, "length": 351, "protein_name": "cAMP-dependent protein kinase catalytic subunit alpha", "gene_name": "PRKACA", "organism": "Bovine", "refseq_name": "cAMP-dependent protein kinase catalytic subunit alpha", "refseq_ac": [ { "id": "NP_777009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777009", "type": "external" } ], "gene_names_uniprotkb": "PRKACA", "gene_names_refseq": "PRKACA", "protein_names_uniprotkb": "cAMP-dependent protein kinase catalytic subunit alpha; 2.7.11.11; PKA C-alpha", "protein_names_refseq": "PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase, cAMP-dependent, catalytic, alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:282322); (R-BTA-163615); (R-BTA-164378); (R-BTA-180024); (R-BTA-2565942); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-381676); (R-BTA-392517); (R-BTA-422356); (R-BTA-432040); (R-BTA-4420097); (R-BTA-442720); (R-BTA-512988); (R-BTA-5578775); (R-BTA-5610785); (R-BTA-5610787); (R-BTA-5620912); (R-BTA-5621575); (R-BTA-5687128); (R-BTA-8853659); (R-BTA-8854518); (R-BTA-8963896); (R-BTA-9634597); (R-BTA-983231); (R-BTA-9837999); (R-BTA-9856530)", "pathway_count": 29, "publication_count": 14, "publication_id_list": "10684253;11152138;1420367;14656443;15096524;23410952;26522383;31484930;6262777;6286662;6311252;8824261;9438863;9521123", "class_list": "", "function": "Data indicate that mitochondrial cAMP-dependent protein kinase (PKA) activity is regulated by the protease calpain., [RefSeq, PubMed]; Data show that the response of the energy landscape upon cyclic AMP (cAMP) binding is domain specific of protein kinase A (PKA). Publication Status: Online-Only, [RefSeq, PubMed]; PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1, [RefSeq, PubMed]; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (By similarity). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (By similarity). Acts as a key inhibitor of smoothened signaling pathway by mediating phosphorylation of GLI (GLI1, GLI2 and GLI3) transcription factors in absence of hedgehog (DHH, IHH or SHH) morphogens: GLI phosphorylation promotes their processing and prevents transcriptional activation of smoothened target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Also inhibits the smoothened signaling pathway in embryonic development by catalyzing phosphorylation of OFD1 in ciliogenesis (By similarity). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR. Phosphorylates AKAP19 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet", "go_biological_process": "GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate;GO:0006397 mRNA processing;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0010898 positive regulation of triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P00517-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00735-1", "uniprot_id": [ { "id": "THRB_BOVIN", "url": "https://www.uniprot.org/uniprot/P00735", "type": "external" } ], "mass": 70506.0, "length": 625, "protein_name": "Prothrombin", "gene_name": "F2", "organism": "Bovine", "refseq_name": "prothrombin precursor", "refseq_ac": [ { "id": "NP_776302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776302", "type": "external" } ], "gene_names_uniprotkb": "F2", "gene_names_refseq": "F2", "protein_names_uniprotkb": "Prothrombin; 3.4.21.5; Coagulation factor II", "protein_names_refseq": "prothrombin precursor; prothrombin; thrombin", "tax_id": 9913, "disease": "", "pathway": " (bta:280685); (R-BTA-159740); (R-BTA-159763); (R-BTA-159782); (R-BTA-202733); (R-BTA-375276); (R-BTA-416476); (R-BTA-456926); (R-BTA-9769733); (R-BTA-9769735); (R-BTA-9769739); (R-BTA-9769743); (R-BTA-977606)", "pathway_count": 13, "publication_count": 18, "publication_id_list": "12923575;1517214;1518046;1547238;1560020;1856869;22004609;23161548;23812842;3000440;33672736;3379642;36724509;3741841;447725;6326805;8947023;9342325", "class_list": "", "function": "Functional Characterization of Antithrombin Mutations by Monitoring of Thrombin Inhibition Kinetics. Publication Status: Online-Only, [RefSeq, PubMed]; Novel pyranosic sulfated arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated polysaccharides and glycosaminoglycans, [RefSeq, PubMed]; The signaling pathways of MAPK, MSK1, and NF-kappaB play important roles in thrombin-induced iNOS expression in alveolar macrophages, [RefSeq, PubMed]; The weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface., [RefSeq, PubMed]; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (By similarity). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3MHK7", "ec_number_list": [ { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "3.4.21.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6", "type": "external" }, { "id": "3.4.21.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.21", "type": "external" }, { "id": "4.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0070051 fibrinogen binding;GO:0008201 heparin binding;GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006953 acute-phase response;GO:0030168 platelet activation;GO:0030194 positive regulation of blood coagulation;GO:0051258 protein polymerization", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P00735-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZBF7-1", "uniprot_id": [ { "id": "TEBP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3ZBF7", "type": "external" } ], "mass": 18697.0, "length": 160, "protein_name": "Prostaglandin E synthase 3", "gene_name": "PTGES3", "organism": "Bovine", "refseq_name": "prostaglandin E synthase 3", "refseq_ac": [ { "id": "NP_001007807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007807", "type": "external" } ], "gene_names_uniprotkb": "PTGES3", "gene_names_refseq": "CPGES; PTGES3", "protein_names_uniprotkb": "Prostaglandin E synthase 3; 5.3.99.3; Cytosolic prostaglandin E2 synthase; cPGES", "protein_names_refseq": "cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; prostaglandin E synthase 3 (cytosolic); prostaglandin E synthase 3", "tax_id": 9913, "disease": "", "pathway": " (bta:493638); (R-BTA-2162123); (R-BTA-3371497); (R-BTA-3371511); (R-BTA-3371568); (R-BTA-8937144); (R-BTA-8939211); (R-BTA-9018519)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "15744024", "class_list": "", "function": "CPGES1 is not the only prostaglandin synthase present in the bovine endometrium but is the main enzyme associated with increased prostaglandin E production in vitro., [RefSeq, PubMed]; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66LN1", "ec_number_list": [ { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" } ], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0070182 DNA polymerase binding;GO:0051879 Hsp90 protein binding;GO:0050220 prostaglandin-E synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005697 telomerase holoenzyme complex;GO:0101031 protein folding chaperone complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0051131 chaperone-mediated protein complex assembly;GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3ZBF7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BPK6-1", "uniprot_id": [ { "id": "MYO6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BPK6", "type": "external" } ], "mass": 149616.0, "length": 1295, "protein_name": "Unconventional myosin-VI", "gene_name": "MYO6", "organism": "Bovine", "refseq_name": "unconventional myosin-VI isoform X1", "refseq_ac": [ { "id": "XP_005210731", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210731", "type": "external" } ], "gene_names_uniprotkb": "MYO6", "gene_names_refseq": "MYO6", "protein_names_uniprotkb": "Unconventional myosin-VI; Unconventional myosin-6", "protein_names_refseq": "unconventional myosin-VI isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:535127); (R-BTA-190873); (R-BTA-399719); (R-BTA-9013418); (R-BTA-9013420); (R-BTA-9013422)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "19393038;22039235", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (By similarity). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (By similarity). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (By similarity). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Required for the correct localization of CLIC5 and RDX at the stereocilium base (By similarity). Modulates RNA polymerase II-dependent transcription (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E1BPK6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97593-1", "uniprot_id": [ { "id": "SMC1A_BOVIN", "url": "https://www.uniprot.org/uniprot/O97593", "type": "external" } ], "mass": 143248.0, "length": 1233, "protein_name": "Structural maintenance of chromosomes protein 1A", "gene_name": "SMC1A", "organism": "Bovine", "refseq_name": "structural maintenance of chromosomes protein 1A", "refseq_ac": [ { "id": "NP_777039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777039", "type": "external" } ], "gene_names_uniprotkb": "SMC1A; SMC1L1; SMC1", "gene_names_refseq": "SMC-1A; SMC1A; SMC1L1", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 1A; SMC protein 1A; SMC-1A", "protein_names_refseq": "SMC protein 1A; SMC-protein; SMC1 structural maintenance of chromosomes 1-like 1; structural maintenance of chromosomes protein 1A", "tax_id": 9913, "disease": "", "pathway": " (bta:282370); (R-BTA-2467813); (R-BTA-2468052); (R-BTA-2470946); (R-BTA-2500257); (R-BTA-3108214)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "10072753;15087462;16043481;8670910", "class_list": "", "function": "Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (By similarity). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint., [UniProtKB]; Only the transition into the coiled-coil region rather than the entire coiled-coil region is necessary for DNA binding, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036033 mediator complex binding", "go_cellular_component": "GO:0030893 meiotic cohesin complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000776 kinetochore;GO:0031981 nuclear lumen", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division;GO:0009314 response to radiation;GO:0072423 response to DNA damage checkpoint signaling;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O97593-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00760-1", "uniprot_id": [ { "id": "TRY1_BOVIN", "url": "https://www.uniprot.org/uniprot/P00760", "type": "external" } ], "mass": 25785.0, "length": 246, "protein_name": "Serine protease 1", "gene_name": "LOC615026; PRSS1", "organism": "Bovine", "refseq_name": "serine protease 1 precursor", "refseq_ac": [ { "id": "NP_001107199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107199", "type": "external" } ], "gene_names_uniprotkb": "LOC615026; PRSS1; TRP1; TRY1; TRYP1", "gene_names_refseq": "PRSS1", "protein_names_uniprotkb": "Serine protease 1; 3.4.21.4; Anionic trypsin I; Anionic trypsin-I; Beta-trypsin; Cationic trypsin; Pretrypsinogen I; Trypsin I; Trypsin-I", "protein_names_refseq": "anionic trypsin I; beta-trypsin; pretrypsinogen I; serine protease 1 precursor; serine protease 1; trypsin I; trypsin, beta", "tax_id": 9913, "disease": "", "pathway": " (bta:615026); (bta:780933)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "1092332;11057674;17087724;17640870;20886466;23335990;25823683;32787139;4399051;512;556951;5892911;5967094", "class_list": "", "function": "Isothermal titration calorimetry was used to obtain Michaelis-Menten plots for the trypsin-catalyzed hydrolysis of several substrates at different temperatures (278-318K)., [RefSeq, PubMed]; The identification of fluorinated fragments binding to the serine protease trypsin, and the X-ray structures of the complexes are presented., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H6Y3", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0097655 serpin family protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0097180 serine protease inhibitor complex;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P00760-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00593-1", "uniprot_id": [ { "id": "PA21B_BOVIN", "url": "https://www.uniprot.org/uniprot/P00593", "type": "external" } ], "mass": 16002.0, "length": 145, "protein_name": "Phospholipase A2", "gene_name": "PLA2G1B", "organism": "Bovine", "refseq_name": "phospholipase A2 preproprotein", "refseq_ac": [ { "id": "NP_777071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777071", "type": "external" } ], "gene_names_uniprotkb": "PLA2G1B", "gene_names_refseq": "PLA2G1B", "protein_names_uniprotkb": "Phospholipase A2; 3.1.1.4; Group IB phospholipase A2; Phosphatidylcholine 2-acylhydrolase 1B", "protein_names_refseq": "group IB phospholipase A2; phosphatidylcholine 2-acylhydrolase 1B; phospholipase A2 preproprotein; phospholipase A2, group IB (pancreas)", "tax_id": 9913, "disease": "", "pathway": " (bta:282457); (R-BTA-1482788); (R-BTA-1482801); (R-BTA-1482839); (R-BTA-1482922); (R-BTA-1482925); (R-BTA-1483166)", "pathway_count": 7, "publication_count": 14, "publication_id_list": "10074343;10074344;10089353;16552140;16790927;22037357;22732705;3562249;620674;712836;7265241;7464926;9115986;9369492", "class_list": "", "function": "Phospholipase A2 isoforms are differentially regulated; they selectively participate in retinal signaling in an experimental model of age-related macular degeneration., [RefSeq, PubMed]; Results suggest the hydrophobic surfactant protein, SP-B, protects alveolar surfactant phospholiopids from hydrolysis mediated by multiple sPLA(2) in both vesicles (alveolar subphase) and monomolecular films (air-liquid interface), [RefSeq, PubMed]; Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). May act in an autocrine and paracrine manner (By similarity). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The crystal structure of the triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2 complexed with an organic molecule, p-methoxybenzoic acid (anisic acid), is reported., [RefSeq, PubMed]; The quadruple mutant of phospholipase A2 has monoclinic or trigonal crystal structures and results suggested evidence for the involvement of the second calcium and surface loop in interfacial binding., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity;GO:0032052 bile acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005576 extracellular region", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006633 fatty acid biosynthetic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P00593-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77836-1", "uniprot_id": [ { "id": "MGT4A_BOVIN", "url": "https://www.uniprot.org/uniprot/O77836", "type": "external" } ], "mass": 61618.0, "length": 535, "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "organism": "Bovine", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "refseq_ac": [ { "id": "NP_803486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803486", "type": "external" } ], "gene_names_uniprotkb": "MGAT4A", "gene_names_refseq": "MGAT4A", "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A; 2.4.1.145; GlcNAc-T IVa; GnT-IVa; N-acetylglucosaminyltransferase IVa; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa", "protein_names_refseq": "N-acetylglucosaminyltransferase IVa; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A; glcNAc-T IVa; gnT-IVa; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A", "tax_id": 9913, "disease": "", "pathway": " (bta:282276); (R-BTA-381426); (R-BTA-8957275); (R-BTA-975577)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "9278430;9565571", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (PubMed:9278430, PubMed:9565571). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0008453 alanine-glyoxylate transaminase activity;GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum;GO:0005795 Golgi stack", "go_biological_process": "GO:0046487 glyoxylate metabolic process;GO:0006487 protein N-linked glycosylation;GO:0006491 N-glycan processing", "synthesized_glycan_count": 3884, "hit_score": 0.4, "record_id": "O77836-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.1000000010001.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02459-1", "uniprot_id": [ { "id": "CO2A1_BOVIN", "url": "https://www.uniprot.org/uniprot/P02459", "type": "external" } ], "mass": 141828.0, "length": 1487, "protein_name": "Collagen alpha-1(II) chain", "gene_name": "COL2A1", "organism": "Bovine", "refseq_name": "collagen alpha-1(II) chain isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_001001135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001135", "type": "external" } ], "gene_names_uniprotkb": "COL2A1", "gene_names_refseq": "CB11; COL2A1", "protein_names_uniprotkb": "Collagen alpha-1(II) chain; Alpha-1 type II collagen", "protein_names_refseq": "alpha-1 type II collagen; collagen alpha-1(II) chain isoform 1 preproprotein; collagen alpha-1(II) chain; collagen, type II, alpha 1; pro-alpha 1(II)", "tax_id": 9913, "disease": "", "pathway": " (bta:407142); (R-BTA-1442490); (R-BTA-1566977); (R-BTA-1650814); (R-BTA-186797); (R-BTA-2022090); (R-BTA-216083); (R-BTA-3000171); (R-BTA-3000178); (R-BTA-8874081); (R-BTA-8948216)", "pathway_count": 11, "publication_count": 13, "publication_id_list": "10479530;22773005;24375478;2582365;2714276;27296271;29017490;32738771;37003165;4857180;7511638;782511;833147", "class_list": "", "function": "A first example of a dominant COL2A1 splice site variant as candidate causal mutation of a severe lethal chondrodysplasia phenotype Publication Status: Online-Only, [RefSeq, PubMed]; Denaturation of the chimeric collagen increased its affinity for fibronectin, as seen for mammalian collagens., [RefSeq, PubMed]; Spontaneous missense mutation within COL2A1 in chondrodysplasia Publication Status: Online-Only, [RefSeq, PubMed]; Structural changes in collagen and aggrecan during extended aging may improve beef tenderness., [RefSeq, PubMed]; Two subsystems of meniscal collagen and their different thermal stabilities., [RefSeq, PubMed]; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 1, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 5, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q28070;Q9XT24;Q9XT25", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0043394 proteoglycan binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0048407 platelet-derived growth factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0007417 central nervous system development;GO:0007601 visual perception;GO:0030199 collagen fibril organization;GO:0007605 sensory perception of sound;GO:0048705 skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P02459-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01001-1", "uniprot_id": [ { "id": "ISK6_BOVIN", "url": "https://www.uniprot.org/uniprot/P01001", "type": "external" } ], "mass": 8663.0, "length": 80, "protein_name": "Serine protease inhibitor Kazal-type 6", "gene_name": "SPINK6", "organism": "Bovine", "refseq_name": "serine protease inhibitor Kazal-type 6 isoform X2", "refseq_ac": [ { "id": "XP_015327798", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015327798", "type": "external" } ], "gene_names_uniprotkb": "SPINK6", "gene_names_refseq": "SPINK6", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 6; Acrosin inhibitor 2; Acrosin inhibitor IIA; BUSI-II", "protein_names_refseq": "serine protease inhibitor Kazal-type 6 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:100335759); (R-BTA-6809371)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "3839023;500016;6306249;6306250;6699915;6864793;6864794", "class_list": "", "function": "Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8. Inhibits acrosin, trypsin, and chymotrypsin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P01001-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02453-1", "uniprot_id": [ { "id": "CO1A1_BOVIN", "url": "https://www.uniprot.org/uniprot/P02453", "type": "external" } ], "mass": 138938.0, "length": 1463, "protein_name": "Collagen alpha-1(I) chain", "gene_name": "COL1A1", "organism": "Bovine", "refseq_name": "collagen alpha-1(I) chain precursor", "refseq_ac": [ { "id": "NP_001029211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029211", "type": "external" } ], "gene_names_uniprotkb": "COL1A1", "gene_names_refseq": "COL1A1", "protein_names_uniprotkb": "Collagen alpha-1(I) chain; Alpha-1 type I collagen", "protein_names_refseq": "alpha-1 type I collagen; collagen alpha-1(I) chain precursor; collagen alpha-1(I) chain; collagen, type I, alpha 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282187)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10517180;10605045;1164916;11946479;1721846;22773005;23220534;24861866;25645914;26495903;26567337;26601954;4115172;4343807;4343808;4359390;4673951;7514515", "class_list": "", "function": "The experiment results demonstrated that the aggregates of collagen incurred in the range of 0.30-0.45 mg/mL, while the more complicated ones emerged at higher concentrations of collagen (0.75 and 1.05 mg/mL)., [RefSeq, PubMed]; The present findings suggest that prolyl 3-hydroxylation incrementally regulates collagen fibril diameter in tendon., [RefSeq, PubMed]; These observations support a signaling network among JNKs, Smads, Snail1, and cortactin to regulate the invasion of MDA-MB-231 cells embedded in 3D collagen I, which may be targeted during screening of anti-invasion reagents., [RefSeq, PubMed]; Two subsystems of meniscal collagen and their different thermal stabilities., [RefSeq, PubMed]; Type I collagen is a member of group I collagen (fibrillar forming collagen)., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3MHM2", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0048407 platelet-derived growth factor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0005584 collagen type I trimer;GO:0005576 extracellular region", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0007601 visual perception;GO:0030199 collagen fibril organization;GO:0045893 positive regulation of DNA-templated transcription;GO:0001568 blood vessel development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P02453-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6Q1T7-1", "uniprot_id": [ { "id": "FUT1_BOVIN", "url": "https://www.uniprot.org/uniprot/F6Q1T7", "type": "external" } ], "mass": 40754.0, "length": 360, "protein_name": "Galactoside alpha-(1,2)-fucosyltransferase 1", "gene_name": "FUT1", "organism": "Bovine", "refseq_name": "galactoside alpha-(1,2)-fucosyltransferase 1", "refseq_ac": [ { "id": "NP_803465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803465", "type": "external" } ], "gene_names_uniprotkb": "FUT1", "gene_names_refseq": "FUT1", "protein_names_uniprotkb": "Galactoside alpha-(1,2)-fucosyltransferase 1; 2.4.1.344; 2.4.1.69; Alpha(1,2)FT 1; Blood group H alpha 2-fucosyltransferase; Fucosyltransferase 1; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1; Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1", "protein_names_refseq": "GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; alpha(1,2)FT 1; alpha(1-2) fucosyltransferase 1; blood group H alpha 2-fucosyltransferase; fucosyltransferase 1 (H blood group); fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group); galactoside 2-alpha-L-fucosyltransferase 1; galactoside alpha-(1,2)-fucosyltransferase 1; type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1; type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1", "tax_id": 9913, "disease": "", "pathway": " (bta:281174); (R-BTA-9033807); (R-BTA-9840309)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10814703;11606704;20506485", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:10814703). H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity). Preferentially fucosylates soluble lactose and to a lesser extent, fucosylates glycolipids gangliosides GA1 and GM1a (PubMed:10814703)., [UniProtKB, PubMed, UniProtKB]; Data show that si-RNA induced down-regulation of FUT1 and FUT2 reduced expression of fucosylated nucleolin glycoforms and their exposure at the cell surface., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9TTY7", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.344", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.344", "type": "external" }, { "id": "2.4.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.69", "type": "external" } ], "go_molecular_function": "GO:0031127 alpha-(1,2)-fucosyltransferase activity;GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0006629 lipid metabolic process;GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0010595 positive regulation of endothelial cell migration", "synthesized_glycan_count": 1540, "hit_score": 0.4, "record_id": "F6Q1T7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02817-1", "uniprot_id": [ { "id": "AMELX_BOVIN", "url": "https://www.uniprot.org/uniprot/P02817", "type": "external" } ], "mass": 24119.0, "length": 213, "protein_name": "Amelogenin, X isoform", "gene_name": "AMELX", "organism": "Bovine", "refseq_name": "amelogenin, X isoform precursor", "refseq_ac": [ { "id": "NP_001014984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014984", "type": "external" } ], "gene_names_uniprotkb": "AMELX", "gene_names_refseq": "AMELX; AMLX; amelogenin", "protein_names_uniprotkb": "Amelogenin, X isoform; Class I amelogenin", "protein_names_refseq": "X-chromosomal amelogenin; amelogenin (X chromosome); amelogenin (amelogenesis imperfecta 1, X-linked); amelogenin, X isoform precursor; class I amelogenin", "tax_id": 9913, "disease": "", "pathway": " (bta:281620); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1989679;1996994;2598664;6732825;8250931", "class_list": "", "function": "Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030345 structural constituent of tooth enamel", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0032967 positive regulation of collagen biosynthetic process;GO:0001649 osteoblast differentiation;GO:0001837 epithelial to mesenchymal transition;GO:0002062 chondrocyte differentiation;GO:0070166 enamel mineralization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P02817-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJW8-1", "uniprot_id": [ { "id": "RPB2_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJW8", "type": "external" } ], "mass": 133867.0, "length": 1174, "protein_name": "DNA-directed RNA polymerase II subunit RPB2", "gene_name": "POLR2B", "organism": "Bovine", "refseq_name": "DNA-directed RNA polymerase II subunit RPB2", "refseq_ac": [ { "id": "NP_001092552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092552", "type": "external" } ], "gene_names_uniprotkb": "POLR2B", "gene_names_refseq": "POLR2B; rpB2", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB2; 2.7.7.48; 2.7.7.6; 3'-5' exoribonuclease; 3.1.13.-; RNA-directed RNA polymerase II subunit RPB2", "protein_names_refseq": "3'-5' exoribonuclease; DNA directed RNA polymerase II polypeptide B; DNA-directed RNA polymerase II subunit RPB2; RNA-directed RNA polymerase II subunit RPB2; polymerase (RNA) II (DNA directed) polypeptide B, 140kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:538184); (R-BTA-112382); (R-BTA-113418); (R-BTA-5578749); (R-BTA-674695); (R-BTA-6781823); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-6796648); (R-BTA-6803529); (R-BTA-6807505); (R-BTA-72086); (R-BTA-72163); (R-BTA-72165); (R-BTA-72203); (R-BTA-73776); (R-BTA-73779); (R-BTA-75953); (R-BTA-75955); (R-BTA-76042); (R-BTA-77075); (R-BTA-9018519); (R-BTA-9770562)", "pathway_count": 23, "publication_count": 4, "publication_id_list": "16769904;26789250;28892040;9604937", "class_list": "", "function": "Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (PubMed:16769904, PubMed:26789250). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (PubMed:16769904, PubMed:26789250). Forms Pol II active center together with the largest subunit POLR2A/RPB1. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:16769904, PubMed:26789250). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:9604937)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB, UniProtKB]; RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MPP6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.1.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.56", "type": "external" }, { "id": "2.1.1.348", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0003968 RNA-directed RNA polymerase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005665 RNA polymerase II, core complex;GO:0000781 chromosome, telomeric region;GO:0005654 nucleoplasm;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006354 DNA-templated transcription elongation;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A5PJW8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00191-1", "uniprot_id": [ { "id": "CP21A_BOVIN", "url": "https://www.uniprot.org/uniprot/P00191", "type": "external" } ], "mass": 56077.0, "length": 496, "protein_name": "Steroid 21-hydroxylase", "gene_name": "CYP21A2; CYP21", "organism": "Bovine", "refseq_name": "steroid 21-hydroxylase", "refseq_ac": [ { "id": "NP_001013614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013614", "type": "external" } ], "gene_names_uniprotkb": "CYP21A2; CYP21; CYP21A1; CYP21A2", "gene_names_refseq": "CYP21A2; CYP21", "protein_names_uniprotkb": "Steroid 21-hydroxylase; 1.14.14.16; 21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21", "protein_names_refseq": "21-OHase; P-450c21; P450-C21; cytochrome P-450c21; cytochrome P450 21; cytochrome P450 XXI; cytochrome P450, family 21; cytochrome P450, subfamily XXI (steroid 21-hydroxylase); cytochrome P450-C21; steroid 21-hydroxylase", "tax_id": 9913, "disease": "", "pathway": " (bta:281741); (R-BTA-193993); (R-BTA-194002); (R-BTA-211976)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "22262854;2424492;25855791;3005319;3487086;6654880", "class_list": "", "function": "A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:22262854, PubMed:25855791). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:22262854, PubMed:25855791)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.16", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.16", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0005496 steroid binding;GO:0020037 heme binding;GO:0004509 steroid 21-monooxygenase activity;GO:0008395 steroid hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0006704 glucocorticoid biosynthetic process;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P00191-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26882-1", "uniprot_id": [ { "id": "PPID_BOVIN", "url": "https://www.uniprot.org/uniprot/P26882", "type": "external" } ], "mass": 40620.0, "length": 370, "protein_name": "Peptidyl-prolyl cis-trans isomerase D", "gene_name": "PPID", "organism": "Bovine", "refseq_name": "peptidyl-prolyl cis-trans isomerase D", "refseq_ac": [ { "id": "NP_776578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776578", "type": "external" } ], "gene_names_uniprotkb": "PPID; CYPD", "gene_names_refseq": "CYP-40; PPID", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase D; 40 kDa peptidyl-prolyl cis-trans isomerase; 5.2.1.8; CYP-40; Cyclophilin-40; Cyclophilin-related protein; Estrogen receptor-binding cyclophilin; PPIase D; Rotamase D", "protein_names_refseq": "40 kDa peptidyl-prolyl cis-trans isomerase; PPIase D; cyclophilin-40; cyclophilin-related protein; estrogen receptor-binding cyclophilin; peptidyl-prolyl cis-trans isomerase D; peptidylprolyl isomerase D (cyclophilin D); rotamase D", "tax_id": 9913, "disease": "", "pathway": " (bta:281420); (R-BTA-8939211)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11377203;1544925;15497503;16650407;20188096;8509368;8514757;8621687;9915798", "class_list": "", "function": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q28077;Q2HJ45", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0008134 transcription factor binding;GO:0030331 nuclear estrogen receptor binding;GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding;GO:0016018 cyclosporin A binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0015031 protein transport;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0050714 positive regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P26882-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01239-1", "uniprot_id": [ { "id": "PRL_BOVIN", "url": "https://www.uniprot.org/uniprot/P01239", "type": "external" } ], "mass": 25793.0, "length": 229, "protein_name": "Prolactin", "gene_name": "PRL", "organism": "Bovine", "refseq_name": "prolactin precursor", "refseq_ac": [ { "id": "NP_776378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776378", "type": "external" } ], "gene_names_uniprotkb": "PRL", "gene_names_refseq": "GHA1; PRL; Prol", "protein_names_uniprotkb": "Prolactin; PRL", "protein_names_refseq": "growth hormone A1; prolactin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280901); (R-BTA-1170546); (R-BTA-982772)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12561222;31920159;31953323;32069836;4608931;5507606;6086257;6274859;6299665;6897772;8250856", "class_list": "", "function": "A dependency between PRL gene polymorphism and breeding parameters in Polish Black-and-White Holstein-Friesian cows., [RefSeq, PubMed]; PRL/microRNA-183/IRS1 Pathway Regulates Milk Fat Metabolism in Cow Mammary Epithelial Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Prolactin acts primarily on the mammary gland by promoting lactation., [UniProtKB]; Protein secondary structure determines the temporal relationship between folding and disulfide formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QLX8;Q29417;Q95112", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0005576 extracellular region", "go_biological_process": "GO:1903576 response to L-arginine;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0009058 biosynthetic process;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P01239-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02522-1", "uniprot_id": [ { "id": "CRBB2_BOVIN", "url": "https://www.uniprot.org/uniprot/P02522", "type": "external" } ], "mass": 23298.0, "length": 205, "protein_name": "Beta-crystallin B2", "gene_name": "CRYBB2", "organism": "Bovine", "refseq_name": "beta-crystallin B2", "refseq_ac": [ { "id": "NP_777232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777232", "type": "external" } ], "gene_names_uniprotkb": "CRYBB2", "gene_names_refseq": "CRYBB2", "protein_names_uniprotkb": "Beta-crystallin B2; Beta-B2 crystallin; Beta-crystallin Bp", "protein_names_refseq": "beta-B2 crystallin; beta-crystallin B2; beta-crystallin Bp", "tax_id": 9913, "disease": "", "pathway": " (bta:287011)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17651443;17937660;19085379;19206113;2234050;3427982;7035168;8477703;8954094", "class_list": "", "function": "Combined with previously reported observations of alpha-crystallin quaternary structure have led us to propose a structural model of how activated alpha-crystallin chaperones unfolded betaB2-crystallin, [RefSeq, PubMed]; Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB]; Detection & sructure of the betaB2-B3-crystallin heterodimer; results suggest the betaB2 subunit adopts a more compacted form than in its monomeric form in order for much of its structure to be enveloped by the betaB3 subunit within the heterodimer, [RefSeq, PubMed]; Mass spectrometry analysis and a database search identified carbamylated proteins originating from alphaA-crystallin, betaB2- and gammaS-(betaS)-crystallins., [RefSeq, PubMed]; Results show that both betaB2- and betaA3-crystallin bind calcium with moderate affinity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 11, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens;GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P02522-1", "record_type": "protein", "filter_code": "0000000.0010101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDL6-1", "uniprot_id": [ { "id": "AT1A2_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDL6", "type": "external" } ], "mass": 112179.0, "length": 1020, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-2", "gene_name": "ATP1A2", "organism": "Bovine", "refseq_name": "sodium/potassium-transporting ATPase subunit alpha-2", "refseq_ac": [ { "id": "NP_001074993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074993", "type": "external" } ], "gene_names_uniprotkb": "ATP1A2", "gene_names_refseq": "ATP1A2", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-2; 7.2.2.13; Na(+)/K(+) ATPase alpha-2 subunit; Sodium pump subunit alpha-2", "protein_names_refseq": "ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; Na(+)/K(+) ATPase alpha-2 subunit; sodium pump subunit alpha-2; sodium/potassium-transporting ATPase subunit alpha-2", "tax_id": 9913, "disease": "", "pathway": " (bta:515161); (R-BTA-5578775); (R-BTA-936837)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12657675;19101784", "class_list": "", "function": "Biochemical and biophysical characteristics of the alpha(2)beta(1) isozyme of Na(+)/K(+)-ATPase from caveolae vesicles of pulmonary smooth muscle plasma membrane were studied during solubilization and purification, [RefSeq, PubMed]; Catalytic subunit of the Na(+)/K(+)-ATPase that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle (By similarity). It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.13", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity;GO:0030955 potassium ion binding;GO:0005391 P-type sodium:potassium-exchanging transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043025 neuronal cell body;GO:0031090 organelle membrane", "go_biological_process": "GO:0008015 blood circulation;GO:0008016 regulation of heart contraction;GO:0006883 intracellular sodium ion homeostasis;GO:0010996 response to auditory stimulus;GO:0007154 cell communication", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2VDL6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFH6-1", "uniprot_id": [ { "id": "PPLA_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFH6", "type": "external" } ], "mass": 6054.0, "length": 52, "protein_name": "Phospholamban", "gene_name": "PLN", "organism": "Bovine", "refseq_name": "phospholamban", "refseq_ac": [ { "id": "NP_001096789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096789", "type": "external" } ], "gene_names_uniprotkb": "PLN", "gene_names_refseq": "PLB; PLN", "protein_names_uniprotkb": "Phospholamban; PLB", "protein_names_refseq": "Cardiac phospholamban; phospholamban", "tax_id": 9913, "disease": "", "pathway": " (bta:100125240)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17060615", "class_list": "", "function": "Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle. Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Also inhibits the activity of ATP2A3/SERCA3. Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation. In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0042030 ATPase inhibitor activity", "go_cellular_component": "GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016529 sarcoplasmic reticulum;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:1901895 negative regulation of ATPase-coupled calcium transmembrane transporter activity;GO:0008542 visual learning;GO:0006874 intracellular calcium ion homeostasis;GO:0010459 negative regulation of heart rate;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4IFH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H782-1", "uniprot_id": [ { "id": "TEKT3_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H782", "type": "external" } ], "mass": 56681.0, "length": 490, "protein_name": "Tektin-3", "gene_name": "TEKT3", "organism": "Bovine", "refseq_name": "tektin-3", "refseq_ac": [ { "id": "NP_001092489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092489", "type": "external" } ], "gene_names_uniprotkb": "TEKT3; OMC45", "gene_names_refseq": "OMC45; TEKT3", "protein_names_uniprotkb": "Tektin-3", "protein_names_refseq": "tektin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:522915)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19478333;26268136;27883267;34715025;37327785", "class_list": "", "function": "Identify/characterize OMC45, a constituent of the intra-acrosomal framework of the bovine sperm acrosome which plays a role in the regulation of hydrolases released during the acrosome reaction., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (PubMed:34715025, PubMed:37327785). Required for normal sperm mobility (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Translocation of TEKT3 to the equatorial segment may be a capacitation- or hyperactivation-associated phenomenon in bull spermatozoa., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 5, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0002080 acrosomal membrane;GO:0005879 axonemal microtubule", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0060378 regulation of brood size;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A6H782-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQJ8-1", "uniprot_id": [ { "id": "ZC12A_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQJ8", "type": "external" } ], "mass": 64263.0, "length": 583, "protein_name": "Ribonuclease ZC3H12A", "gene_name": "ZC3H12A", "organism": "Bovine", "refseq_name": "ribonuclease ZC3H12A", "refseq_ac": [ { "id": "NP_001095657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095657", "type": "external" } ], "gene_names_uniprotkb": "ZC3H12A", "gene_names_refseq": "ZC3H12A", "protein_names_uniprotkb": "Ribonuclease ZC3H12A; 3.1.-.-; Zinc finger CCCH domain-containing protein 12A", "protein_names_refseq": "Zinc finger CCCH domain-containing protein 12A; ribonuclease ZC3H12A", "tax_id": 9913, "disease": "", "pathway": " (bta:535344)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30590418", "class_list": "", "function": "Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA. Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (By similarity). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (By similarity). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (By similarity). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (By similarity). Affects the overall ubiquitination of cellular proteins. Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Also induces deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (By similarity). Prevents stress granules (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock, and energy deprivation. Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state. May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (By similarity). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (By similarity). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Findings indicate that monocyte chemoattractant protein-induced protein 1 (MCPIP1) may regulate the inflammatory response of bovine mammary epithelial cells during infection, suggeting a therapeutic target for bovine mastitis to reduce the damage caused by inflammatory reactions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0000932 P-body", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:1990869 cellular response to chemokine;GO:2000320 negative regulation of T-helper 17 cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QQJ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C7EXK4-1", "uniprot_id": [ { "id": "AT8A2_BOVIN", "url": "https://www.uniprot.org/uniprot/C7EXK4", "type": "external" } ], "mass": 129037.0, "length": 1148, "protein_name": "Phospholipid-transporting ATPase IB", "gene_name": "ATP8A2", "organism": "Bovine", "refseq_name": "phospholipid-transporting ATPase IB isoform 2", "refseq_ac": [ { "id": "NP_001157274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157274", "type": "external" } ], "gene_names_uniprotkb": "ATP8A2", "gene_names_refseq": "ATP8A2", "protein_names_uniprotkb": "Phospholipid-transporting ATPase IB; 7.6.2.1; ATPase class I type 8A member 2; P4-ATPase flippase complex alpha subunit ATP8A2", "protein_names_refseq": "ATPase class I type 8A member 2; ATPase, aminophospholipid transporter-like, class I, type 8A, member 2; P4-ATPase flippase complex alpha subunit ATP8A2; phospholipid-transporting ATPase IB isoform 2; probable phospholipid-transporting ATPase IB", "tax_id": 9913, "disease": "", "pathway": " (bta:508723)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19778899;21454556;22307598;24706822;26592152;31371510", "class_list": "", "function": "CDC50A is the beta-subunit of ATP8A2 and is crucial for the correct folding, stable expression, export from endoplasmic reticulum, and phosphatidylserine flippase activity of ATP8A2, [RefSeq, PubMed]; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:19778899, PubMed:24706822, PubMed:26592152, PubMed:31371510). Able to translocate phosphatidylserine, but not phosphatidylcholine (By similarity). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:19778899, PubMed:24706822, PubMed:26592152, PubMed:31371510). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (PubMed:31371510). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Mutations in mammalian P4-ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit, [RefSeq, PubMed]; P4-ATPase Atp8a2 is a phosphatidylserine flippase in photoreceptor disc membranes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 33, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090555 phosphatidylethanolamine flippase activity;GO:0090556 phosphatidylserine floppase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0097381 photoreceptor disc membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0048666 neuron development;GO:0140331 aminophospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "C7EXK4-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MSG6-1", "uniprot_id": [ { "id": "RPGF2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MSG6", "type": "external" } ], "mass": 165144.0, "length": 1486, "protein_name": "Rap guanine nucleotide exchange factor 2", "gene_name": "RAPGEF2", "organism": "Bovine", "refseq_name": "rap guanine nucleotide exchange factor 2", "refseq_ac": [ { "id": "NP_001178255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178255", "type": "external" } ], "gene_names_uniprotkb": "RAPGEF2; NRAPGEP; PDZGEF1", "gene_names_refseq": "PDZ-GEF1; RA-GEF-1; RAPGEF2; nRap GEP", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 2; CNrasGEF; Cyclic nucleotide ras GEF; Neural RAP guanine nucleotide exchange protein; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ-GEF1; RA-GEF-1; Ras/Rap1-associating GEF-1; nRap GEP", "protein_names_refseq": "CNrasGEF; PDZ domain-containing guanine nucleotide exchange factor 1; Rap guanine nucleotide exchange factor (GEF) 2; cyclic nucleotide ras GEF; neural RAP guanine nucleotide exchange protein; rap guanine nucleotide exchange factor 2; ras/Rap1-associating GEF-1", "tax_id": 9913, "disease": "", "pathway": " (bta:100139484); (R-BTA-5673001)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10873669;19393038;23800469", "class_list": "", "function": "Data indicate that Rapgef2 is a cAMP-binding protein present in chromaffin cells. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions (By similarity). Binds to cAMP., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0050699 WW domain binding;GO:0030165 PDZ domain binding;GO:0031697 beta-1 adrenergic receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0048022 negative regulation of melanin biosynthetic process;GO:0061028 establishment of endothelial barrier;GO:0032486 Rap protein signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1MSG6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MZY8-1", "uniprot_id": [ { "id": "RPB1_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MZY8", "type": "external" } ], "mass": 217192.0, "length": 1970, "protein_name": "DNA-directed RNA polymerase II subunit RPB1", "gene_name": "POLR2A", "organism": "Bovine", "refseq_name": "DNA-directed RNA polymerase II subunit RPB1", "refseq_ac": [ { "id": "NP_001193242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193242", "type": "external" } ], "gene_names_uniprotkb": "POLR2A", "gene_names_refseq": "POLR2A", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB1; 2.7.7.48; 2.7.7.6; 3'-5' exoribonuclease; 3.1.13.-; RNA-directed RNA polymerase II subunit RPB1", "protein_names_refseq": "3'-5' exoribonuclease; DNA-directed RNA polymerase II subunit RPB1; RNA-directed RNA polymerase II subunit RPB1; polymerase (RNA) II (DNA directed) polypeptide A (220kD); polymerase (RNA) II (DNA directed) polypeptide A, 220kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:282312); (R-BTA-112382); (R-BTA-113418); (R-BTA-5578749); (R-BTA-674695); (R-BTA-6781823); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-6796648); (R-BTA-6803529); (R-BTA-6807505); (R-BTA-72086); (R-BTA-72163); (R-BTA-72165); (R-BTA-72203); (R-BTA-73776); (R-BTA-73779); (R-BTA-75953); (R-BTA-75955); (R-BTA-76042); (R-BTA-77075); (R-BTA-9018519); (R-BTA-9770562)", "pathway_count": 23, "publication_count": 5, "publication_id_list": "16769904;19393038;26789250;28892040;9604937", "class_list": "", "function": "Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (PubMed:16769904, PubMed:26789250). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:16769904, PubMed:26789250). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (PubMed:16769904, PubMed:26789250). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:9604937). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 44, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.1.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.56", "type": "external" }, { "id": "2.1.1.348", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0003968 RNA-directed RNA polymerase activity;GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0001046 core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0000791 euchromatin;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0042789 mRNA transcription by RNA polymerase II;GO:0006369 termination of RNA polymerase II transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3MZY8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02740-1", "uniprot_id": [ { "id": "GUC2F_BOVIN", "url": "https://www.uniprot.org/uniprot/O02740", "type": "external" } ], "mass": 124262.0, "length": 1103, "protein_name": "Retinal guanylyl cyclase 2", "gene_name": "GUCY2F", "organism": "Bovine", "refseq_name": "retinal guanylyl cyclase 2 precursor", "refseq_ac": [ { "id": "NP_776974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776974", "type": "external" } ], "gene_names_uniprotkb": "GUCY2F; GUC2F", "gene_names_refseq": "GUCY2F", "protein_names_uniprotkb": "Retinal guanylyl cyclase 2; 4.6.1.2; GC-F; Guanylate cyclase 2F, retinal; Guanylate cyclase F; RETGC-2; ROS-GC2; Rod outer segment membrane guanylate cyclase 2", "protein_names_refseq": "GC-F; RETGC-2; ROS-GC2; guanylate cyclase F; retinal guanylyl cyclase 2 precursor; retinal guanylyl cyclase 2; rod outer segment membrane guanylate cyclase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282246)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25767116;9175772;9571173", "class_list": "", "function": "Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:9175772, PubMed:9571173). Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:9175772, PubMed:9571173). May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; The findings define a new regulatory mechanism of the ROS-GC system that affects visual transduction and is likely to affect the course of retinal diseases caused by cGMP toxicity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0001653 peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0120200 rod photoreceptor outer segment", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0007168 receptor guanylyl cyclase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O02740-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18738-1", "uniprot_id": [ { "id": "DAG1_BOVIN", "url": "https://www.uniprot.org/uniprot/O18738", "type": "external" } ], "mass": 97321.0, "length": 895, "protein_name": "Dystroglycan 1", "gene_name": "DAG1", "organism": "Bovine", "refseq_name": "dystroglycan 1 precursor", "refseq_ac": [ { "id": "NP_776587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776587", "type": "external" } ], "gene_names_uniprotkb": "DAG1", "gene_names_refseq": "DAG1; RAB7", "protein_names_uniprotkb": "Dystroglycan 1; Dystroglycan; Dystrophin-associated glycoprotein 1", "protein_names_refseq": "RAB7, member RAS oncogene family; dystroglycan 1 precursor; dystrophin-associated glycoprotein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:281439)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10075729;16709410;41018975;8798547;8999917", "class_list": "", "function": "Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. As a receptor for laminin is involved in extracellular matrix assembly, and activation of the PI3K/AKT pathway regulating cell apoptotic signals in muscle (By similarity). Binding of laminin LAMA1 to alpha-dystroglycan also initiates a signaling cascade in which Src kinases, c-Src or c-Fyn, phosphorylate syntrophin modifying its interaction with the adapter protein GRB2; this triggers recruitment of guanyl-nucleotide exchange factor SOS1 and activation of RAC1, finally resulting in c-Jun phosphorylation by MAPK8/JNK1 (By similarity). As a receptor for laminin LAMA1 is also involved in epithelium branching morphogenesis in salivary glang and lung (By similarity). Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells (PubMed:8798547). Also acts as a receptor for laminin LAMA5 (PubMed:16709410). In muscle cells, it is a receptor for laminin-1 (also known as laminin-111 or EHS laminin) and is involved in the stimulation of agrin-induced acetylcholine receptor (AChR) clustering, and formation of the synaptic basement membrane. It is required for acetylcholinesterase (AChE) localization at the neuromuscular junctions (NMJ) through its binding with perlecan (HSPG2) and is, therefore, involved in the down-regulation of colinergic synaptic transmission (By similarity). In the retina, it is required for the formation of photoreceptor ribbon synapses through its interaction with pikachurin (EGFLAM) (By similarity). Also involved in the positive regulation of cartilage formation through agrin (AGRN) binding and up-regulation of SOX9, a transcription factor that plays a key role in chondrocytes differentiation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, PubMed]; The dystroglycan complex is involved in a number of signaling events and processes including laminin deposition and extracellular matrix assembly, acetylcholine receptor clustering, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, epithelial polarization, and epithelium branching morphogenesis (By similarity). Required for the formation of photoreceptor ribbon synapses, and long-term maintenance of inhibitory synapses in cerebellar Purkinje cells (By similarity). Also involved in the positive regulation of cartilage formation through agrin (AGRN) binding and up-regulation of SOX9, a transcription factor that plays a key role in chondrocytes differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity (By similarity)., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 4, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0043236 laminin binding;GO:0005055 laminin receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0035022 positive regulation of Rac protein signal transduction;GO:0021675 nerve development;GO:0007411 axon guidance;GO:0002009 morphogenesis of an epithelium;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O18738-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18964-1", "uniprot_id": [ { "id": "SYNJ1_BOVIN", "url": "https://www.uniprot.org/uniprot/O18964", "type": "external" } ], "mass": 143695.0, "length": 1300, "protein_name": "Polyphosphatidylinositol phosphatase SYNJ1", "gene_name": "SYNJ1", "organism": "Bovine", "refseq_name": "synaptojanin-1", "refseq_ac": [ { "id": "NP_776893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776893", "type": "external" } ], "gene_names_uniprotkb": "SYNJ1", "gene_names_refseq": "SYNJ1", "protein_names_uniprotkb": "Polyphosphatidylinositol phosphatase SYNJ1; 3.1.3.-; 3.1.3.95; Inositol polyphosphate-5-phosphatase G; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase SYNJ1; Phosphatidylinositol-4-phosphatase SYNJ1; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1; Synaptojanin-1; p150", "protein_names_refseq": "p150; synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1; synaptojanin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:282087)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19393038;19922587;9199318", "class_list": "", "function": "Phosphatase that hydrolyzes phosphate groups from the inositol ring of phosphoinositides and inositol phosphates, in a domain-specific manner (PubMed:9199318). The 5-PPase domain catalyzes removal of the 5-phosphate from substrates such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) (PubMed:9199318). The SAC domain hydrolyzes phosphates at the 3- and 4-positions of the inositol ring, targeting phosphatidylinositol-3-phosphate (PI(3)P), phosphatidylinositol-4-phosphate (PI(4)P), and phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2) (By similarity). Plays a role in the phosphatidylinositol metabolic process during an unconventional endocytic mechanism, the ultrafast endocytosis where it participates in the rapide neck formation of the newly generated synaptic vesicle through its phosphoinositide 5-phosphatase activity. Also, participates in the clathrin uncoating of synaptc vesicle formed via budding from synaptic endosomes after ultrafast endocytosis through combined activity of its phosphatase domains (By similarity). Additionally, regulates actin filament rearrangement by hydrolyzing PIP2 bound to actin regulatory proteins (PubMed:9199318)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Study concludes that the bSYNJ1_C3981T SNP can be ruled out as a functional mutation for polledness in German Holstein, Limousin, Charolais and Pinzgauer cattle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MC12", "ec_number_list": [ { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0098793 presynapse", "go_biological_process": "GO:0031161 phosphatidylinositol catabolic process;GO:0046856 phosphatidylinositol dephosphorylation;GO:0036465 synaptic vesicle recycling;GO:0046488 phosphatidylinositol metabolic process;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O18964-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77788-1", "uniprot_id": [ { "id": "NFM_BOVIN", "url": "https://www.uniprot.org/uniprot/O77788", "type": "external" } ], "mass": 103210.0, "length": 926, "protein_name": "Neurofilament medium polypeptide", "gene_name": "NEFM", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NEFM; NEF3; NFM", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurofilament medium polypeptide; 160 kDa neurofilament protein; NF-M; Neurofilament 3; Neurofilament triplet M protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "14967049", "class_list": "", "function": "Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 35, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0030424 axon;GO:0005882 intermediate filament;GO:0099160 postsynaptic intermediate filament cytoskeleton", "go_biological_process": "GO:0033693 neurofilament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O77788-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77834-1", "uniprot_id": [ { "id": "PRDX6_BOVIN", "url": "https://www.uniprot.org/uniprot/O77834", "type": "external" } ], "mass": 25067.0, "length": 224, "protein_name": "Peroxiredoxin-6", "gene_name": "PRDX6", "organism": "Bovine", "refseq_name": "peroxiredoxin-6", "refseq_ac": [ { "id": "NP_777068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777068", "type": "external" } ], "gene_names_uniprotkb": "PRDX6; AOP2; GPX; PHGPX", "gene_names_refseq": "AOP2; LPCAT-5; PRDX6", "protein_names_uniprotkb": "Peroxiredoxin-6; 1-Cys PRX; 1-Cys peroxiredoxin; 1.11.1.27; 2.3.1.23; 3.1.1.4; Acidic calcium-independent phospholipase A2; Antioxidant protein 2; Ciliary body glutathione peroxidase; Glutathione-dependent peroxiredoxin; LPC acyltransferase 5; LPCAT-5; Lyso-PC acyltransferase 5; Lysophosphatidylcholine acyltransferase 5; NSGPx; Non-selenium glutathione peroxidase; PHGPx; aiPLA2", "protein_names_refseq": "1-Cys PRX; 1-Cys peroxiredoxin; LPC acyltransferase 5; NSGPx; PHGPx; aiPLA2; anti-oxidant protein 2 (non-selenium glutathione peroxidase, acidic calcium-independent phospholipase A2); antioxidant protein 2; ciliary body glutathione peroxidase; glutathione-dependent peroxiredoxin; lyso-PC acyltransferase 5; lysophosphatidylcholine acyltransferase 5; peroxiredoxin-6", "tax_id": 9913, "disease": "", "pathway": " (bta:282438); (R-BTA-3299685); (R-BTA-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10409692;12810819;15004285;15240427;16305752;22306096;2373154;9748299;9787801", "class_list": "", "function": "DsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by iPLA2., [RefSeq, PubMed]; PRDX6 upregulation in cumulus-oocyte complexes during in vitro maturation is mutually regulated by both cell types., [RefSeq, PubMed]; Study demonstrated involvement of cytosolic and calcium-independent phospholipase A(2) and the contribution of cyclooxygenase-2 products in E. coli invasion of brain microvascular endothelial cells, [RefSeq, PubMed]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10409692, PubMed:2373154). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10409692). Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10409692, PubMed:2373154, PubMed:9787801). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5E9F3", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0051920 peroxiredoxin activity;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0000302 response to reactive oxygen species;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O77834-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97594-1", "uniprot_id": [ { "id": "SMC3_BOVIN", "url": "https://www.uniprot.org/uniprot/O97594", "type": "external" } ], "mass": 142024.0, "length": 1218, "protein_name": "Structural maintenance of chromosomes protein 3", "gene_name": "SMC3", "organism": "Bovine", "refseq_name": "structural maintenance of chromosomes protein 3", "refseq_ac": [ { "id": "NP_776720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776720", "type": "external" } ], "gene_names_uniprotkb": "SMC3; CSPG6; SMC3L1", "gene_names_refseq": "CSPG6; SMC-3; SMC3", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 3; Chondroitin sulfate proteoglycan 6; SMC protein 3; SMC-3", "protein_names_refseq": "SMC protein 3; bamacan; chondroitin sulfate proteoglycan 6 (bamacan); structural maintenance of chromosomes protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:281729)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10072753;16043481", "class_list": "", "function": "Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003690 double-stranded DNA binding;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0030892 mitotic cohesin complex;GO:0030893 meiotic cohesin complex;GO:0000775 chromosome, centromeric region;GO:0016363 nuclear matrix;GO:0000785 chromatin", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division;GO:0006275 regulation of DNA replication;GO:0051321 meiotic cell cycle;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O97594-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97859-1", "uniprot_id": [ { "id": "NEUR3_BOVIN", "url": "https://www.uniprot.org/uniprot/O97859", "type": "external" } ], "mass": 47917.0, "length": 428, "protein_name": "Sialidase-3", "gene_name": "NEU3", "organism": "Bovine", "refseq_name": "sialidase-3", "refseq_ac": [ { "id": "NP_776547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776547", "type": "external" } ], "gene_names_uniprotkb": "NEU3", "gene_names_refseq": "NEU3", "protein_names_uniprotkb": "Sialidase-3; 3.2.1.18; Ganglioside sialidase; Membrane sialidase; N-acetyl-alpha-neuraminidase 3; Neuraminidase 3", "protein_names_refseq": "N-acetyl-alpha-neuraminidase 3; ganglioside sialidase; membrane sialidase; sialidase 3 (membrane sialidase); sialidase-3", "tax_id": 9913, "disease": "", "pathway": " (bta:281349)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9988745", "class_list": "glycogene;glycosylhydrolase", "function": "Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:9988745). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" } ], "go_molecular_function": "GO:0004308 exo-alpha-sialidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0009313 oligosaccharide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O97859-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00125-1", "uniprot_id": [ { "id": "CY1_BOVIN", "url": "https://www.uniprot.org/uniprot/P00125", "type": "external" } ], "mass": 35297.0, "length": 325, "protein_name": "Cytochrome c1, heme protein, mitochondrial", "gene_name": "CYC1", "organism": "Bovine", "refseq_name": "cytochrome c1, heme protein, mitochondrial", "refseq_ac": [ { "id": "NP_001033179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033179", "type": "external" } ], "gene_names_uniprotkb": "CYC1", "gene_names_refseq": "CYC1", "protein_names_uniprotkb": "Cytochrome c1, heme protein, mitochondrial; 7.1.1.8; Complex III subunit 4; Complex III subunit IV; Cytochrome b-c1 complex subunit 4; Cytochrome c-1; Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit", "protein_names_refseq": "complex III subunit 4; complex III subunit IV; cytochrome b-c1 complex subunit 4; cytochrome c-1; cytochrome c1, heme protein, mitochondrial; ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:512500); (R-BTA-611105); (R-BTA-9865881)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12269811;12435729;15312779;16024040;16924113;24114362;28100784;6286615;9204897;9651245", "class_list": "", "function": "An analysis of eight structures of mitochondrial bc(1) with bound quinol oxidation (Q(o)) site inhibitors revealed that the presence of inhibitors causes a bidirectional repositioning of the cd1 helix in the cytochrome b subunit., [RefSeq, PubMed]; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c., [UniProtKB, UniProtKB]; Cytochrome c has a role in elimination of reactive oxygen species and hydrogen peroxide from mitochondria, and thus in apoptosis, [RefSeq, PubMed]; Holocytochrome c can interact with tRNA but not apocytochrome c that lacks the heme domain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TBM2", "ec_number_list": [ { "id": "7.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.8", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P00125-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00157-1", "uniprot_id": [ { "id": "CYB_BOVIN", "url": "https://www.uniprot.org/uniprot/P00157", "type": "external" } ], "mass": 42591.0, "length": 379, "protein_name": "Cytochrome b", "gene_name": "MT-CYB", "organism": "Bovine", "refseq_name": "cytochrome b", "refseq_ac": [ { "id": "YP_209217", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209217", "type": "external" } ], "gene_names_uniprotkb": "MT-CYB; COB; CYTB; MTCYB", "gene_names_refseq": "CYTB", "protein_names_uniprotkb": "Cytochrome b; Complex III subunit 3; Complex III subunit III; Cytochrome b-c1 complex subunit 3; Ubiquinol-cytochrome-c reductase complex cytochrome b subunit", "protein_names_refseq": "cytochrome b", "tax_id": 9913, "disease": "", "pathway": " (bta:3283889); (R-BTA-5419276); (R-BTA-611105); (R-BTA-9865881)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "1225597;12269811;1327781;15312779;16024040;16924113;189810;1901092;20025846;7120390;9204897;9485330;9651245", "class_list": "", "function": "Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SE06", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0008121 quinol-cytochrome-c reductase activity;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0022904 respiratory electron transport chain;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P00157-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00366-1", "uniprot_id": [ { "id": "DHE3_BOVIN", "url": "https://www.uniprot.org/uniprot/P00366", "type": "external" } ], "mass": 61512.0, "length": 558, "protein_name": "Glutamate dehydrogenase 1, mitochondrial", "gene_name": "GLUD1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GLUD1; GLUD", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutamate dehydrogenase 1, mitochondrial; 1.4.1.3; GDH 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281785)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10425679;11254391;12653548;14659072;22076378;28100784;429360;4365183;4735572;4856315", "class_list": "", "function": "Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:14659072, PubMed:4365183). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYY0;Q7YS29;Q8HZ49", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0004352 glutamate dehydrogenase (NAD+) activity;GO:0004353 glutamate dehydrogenase [NAD(P)+] activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006541 glutamine metabolic process;GO:0006538 L-glutamate catabolic process;GO:0072350 tricarboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P00366-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00396-1", "uniprot_id": [ { "id": "COX1_BOVIN", "url": "https://www.uniprot.org/uniprot/P00396", "type": "external" } ], "mass": 57032.0, "length": 514, "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "MT-CO1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MT-CO1; COI; COXI; MTCO1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 1; 7.1.1.9; Cytochrome c oxidase polypeptide I", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "10089392;10338009;10771420;20385840;2165784;23537388;26698328;27605664;31533957;7120390;8638158", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006119 oxidative phosphorylation;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P00396-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00429-1", "uniprot_id": [ { "id": "CX6B1_BOVIN", "url": "https://www.uniprot.org/uniprot/P00429", "type": "external" } ], "mass": 10156.0, "length": 86, "protein_name": "Cytochrome c oxidase subunit 6B1", "gene_name": "COX6B1", "organism": "Bovine", "refseq_name": "cytochrome c oxidase subunit 6B1", "refseq_ac": [ { "id": "NP_788848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788848", "type": "external" } ], "gene_names_uniprotkb": "COX6B1; COX6B", "gene_names_refseq": "COX6B1; COX6B", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6B1; COX VIb-1; Cytochrome c oxidase polypeptide VII; Cytochrome c oxidase subunit AED; Cytochrome c oxidase subunit VIb isoform 1", "protein_names_refseq": "COX VIb-1; Cytochrome c oxidase polypeptide VII; Cytochrome c oxidase subunit AED; cytochrome c oxidase subunit 6B1; cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)", "tax_id": 9913, "disease": "", "pathway": " (bta:100270792)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10089392;10771420;20385840;229067;2548168;26698328;27605664;2844245;31533957;6262305;8638158", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q54A32", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P00429-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00430-1", "uniprot_id": [ { "id": "COX7C_BOVIN", "url": "https://www.uniprot.org/uniprot/P00430", "type": "external" } ], "mass": 7331.0, "length": 63, "protein_name": "Cytochrome c oxidase subunit 7C, mitochondrial", "gene_name": "COX7C", "organism": "Bovine", "refseq_name": "cytochrome c oxidase subunit 7C, mitochondrial", "refseq_ac": [ { "id": "XP_005209785", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209785", "type": "external" } ], "gene_names_uniprotkb": "COX7C; COX7CP1", "gene_names_refseq": "COX7C", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7C, mitochondrial; Cytochrome c oxidase polypeptide VIIIA; Cytochrome c oxidase polypeptide VIIc", "protein_names_refseq": "cytochrome c oxidase subunit 7C, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:101902937); (bta:101903567); (bta:327718); (R-BTA-5628897); (R-BTA-611105); (R-BTA-9707564); (R-BTA-9864848)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "10089392;10771420;1655579;20385840;213363;2554257;26698328;27605664;2844245;31533957;8638158;9092564", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0U0;Q56K07", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P00430-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00442-1", "uniprot_id": [ { "id": "SODC_BOVIN", "url": "https://www.uniprot.org/uniprot/P00442", "type": "external" } ], "mass": 15683.0, "length": 152, "protein_name": "Superoxide dismutase [Cu-Zn]", "gene_name": "SOD1", "organism": "Bovine", "refseq_name": "superoxide dismutase [Cu-Zn]", "refseq_ac": [ { "id": "NP_777040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777040", "type": "external" } ], "gene_names_uniprotkb": "SOD1", "gene_names_refseq": "SOD1L1; SOD1", "protein_names_uniprotkb": "Superoxide dismutase [Cu-Zn]; 1.15.1.1; 1.8.-.-; Hydrogen sulfide oxidase", "protein_names_refseq": "Cu-Zn superoxide dismutase; hydrogen sulfide oxidase; superoxide dismutase 1, soluble; superoxide dismutase [Cu-Zn]", "tax_id": 9913, "disease": "", "pathway": " (bta:281495); (R-BTA-114608); (R-BTA-3299685)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10092461;1055410;12906825;1619651;1958215;2263495;26872685;29464366;30079537;31079924;4279916;4436313;518876;6316150;7175933;7643403", "class_list": "", "function": "A pi-H pathway assembled across the beta-sheets from both subunits in the SOD-dimer protein connecting the two Cu-centers and thus the two half-reactions, is described., [RefSeq, PubMed]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (PubMed:518876).Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying H2S and limiting the accumulation of reactive sulfur species (RSS) such as persulfides and polysulfide (By similarity)., [UniProtKB, PubMed, UniProtKB]; Results indicate that variants of the PRLH and SOD1 genes are associated with heat tolerance in Chinese cattle., [RefSeq, PubMed]; The present study aims to evaluate the peritoneal fluid impact from infertile women with minimal and mild endometriosis and from fertile control women without endometriosis on SOD1, CAT, GSR gene's expression in experimental bovine oocytes matured in vitro., [RefSeq, PubMed]; The three-dimensional structure of bSOD1 reveals the imidazole ring of His19 localized within 5A from the alpha-carbon of Gly31 providing a structural basis that copper ion, most likely coordinated by His19, catalyzes the specific cleavage reaction, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCF4", "ec_number_list": [ { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0005507 copper ion binding;GO:0030346 protein phosphatase 2B binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0000303 response to superoxide;GO:0007283 spermatogenesis;GO:0007626 locomotory behavior;GO:0040014 regulation of multicellular organism growth;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P00442-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00515-1", "uniprot_id": [ { "id": "KAP2_BOVIN", "url": "https://www.uniprot.org/uniprot/P00515", "type": "external" } ], "mass": 45094.0, "length": 401, "protein_name": "cAMP-dependent protein kinase type II-alpha regulatory subunit", "gene_name": "PRKAR2A", "organism": "Bovine", "refseq_name": "cAMP-dependent protein kinase type II-alpha regulatory subunit", "refseq_ac": [ { "id": "NP_001178296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178296", "type": "external" } ], "gene_names_uniprotkb": "PRKAR2A", "gene_names_refseq": "PRKAR2A", "protein_names_uniprotkb": "cAMP-dependent protein kinase type II-alpha regulatory subunit", "protein_names_refseq": "cAMP-dependent protein kinase type II-alpha regulatory subunit; protein kinase, cAMP-dependent, regulatory, type 2, alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:100139910); (R-BTA-163615); (R-BTA-164378); (R-BTA-180024); (R-BTA-432040); (R-BTA-442720); (R-BTA-5610787); (R-BTA-9634597); (R-BTA-983231); (R-BTA-9856530)", "pathway_count": 10, "publication_count": 4, "publication_id_list": "15046986;1654846;3030405;6283532", "class_list": "", "function": "Angle X-ray scattering studies indicate RIalpha, RIIalpha, and RIIbeta homodimers differ markedly in overall shape despite extensive sequence homology and similar molecular masses;cAMP binding does not cause large conformational changes(Prkar1a, Prkar2a), [RefSeq, PubMed]; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P00515-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00516-1", "uniprot_id": [ { "id": "KGP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P00516", "type": "external" } ], "mass": 76419.0, "length": 671, "protein_name": "cGMP-dependent protein kinase 1", "gene_name": "PRKG1", "organism": "Bovine", "refseq_name": "cGMP-dependent protein kinase 1", "refseq_ac": [ { "id": "NP_776861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776861", "type": "external" } ], "gene_names_uniprotkb": "PRKG1; PRKG1B; PRKGR1A; PRKGR1B", "gene_names_refseq": "CGKI; PRKG1; cGK 1; cGKI-beta", "protein_names_uniprotkb": "cGMP-dependent protein kinase 1; 2.7.11.12; cGK 1; cGK1; cGKI; cGMP-dependent protein kinase I", "protein_names_refseq": "CGK 1 alpha; cGK 1 beta; cGK1; cGKI-alpha; cGMP-dependent protein kinase 1, alpha isozyme; cGMP-dependent protein kinase 1, beta isozyme; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; protein kinase, cGMP-dependent, type I", "tax_id": 9913, "disease": "", "pathway": " (bta:282004); (R-BTA-392517); (R-BTA-418457)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10724174;11309393;12480535;1325910;16166082;21292805;21893290;21926339;23709600;2537306;2546820;2822399;6091741;6274862;6304091;9099696", "class_list": "", "function": "Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication, [RefSeq, PubMed]; NADPH regulation of PKG1-alpha dimerization may contribute to vascular responses to hypoxia that are associated with changes in NADPH redox., [RefSeq, PubMed]; Report roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia., [RefSeq, PubMed]; Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle (By similarity)., [UniProtKB]; The data suggest that PKG-I expression is subjected to post-transcriptional regulation in VSMC through the 3'UTR of its mRNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P21136", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004692 cGMP-dependent protein kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0005246 calcium channel regulator activity;GO:0030553 cGMP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0090331 negative regulation of platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P00516-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00639-1", "uniprot_id": [ { "id": "DNAS1_BOVIN", "url": "https://www.uniprot.org/uniprot/P00639", "type": "external" } ], "mass": 31346.0, "length": 282, "protein_name": "Deoxyribonuclease-1", "gene_name": "DNASE1", "organism": "Bovine", "refseq_name": "deoxyribonuclease-1 precursor", "refseq_ac": [ { "id": "NP_776959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776959", "type": "external" } ], "gene_names_uniprotkb": "DNASE1; DNL1", "gene_names_refseq": "DNASE1", "protein_names_uniprotkb": "Deoxyribonuclease-1; 3.1.21.1; DNase I; Deoxyribonuclease I", "protein_names_refseq": "DNase I; deoxyribonuclease I; deoxyribonuclease-1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:282217)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14680812;1518054;1748997;19850052;2395459;27570054;29551685;3352748;3560229;3713845;4734471;4735137;4856650;4976790;5166750;9469931", "class_list": "", "function": "Ascorbic acid has the ability to inhibit DNase I, one of the main endonucleases involved in DNA fragmentation during apoptosis., [RefSeq, PubMed]; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2395459, PubMed:3352748, PubMed:4976790, PubMed:5166750). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:2395459). Binds specifically to G-actin and blocks actin polymerization (PubMed:2395459). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Specificity in DNA-DNase I interaction is mediated by DNA flexibility, which influences the induced-fit transitions required to form productive complexes., [RefSeq, PubMed]; The practical capability of this assay system was successfully demonstrated by its use to determine DNase I activity in bovine urine., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5PK44;Q8MJ27", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003779 actin binding;GO:0004530 deoxyribonuclease I activity", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005635 nuclear envelope", "go_biological_process": "GO:0002283 neutrophil activation involved in immune response;GO:0070948 regulation of neutrophil mediated cytotoxicity;GO:0006915 apoptotic process;GO:0006308 DNA catabolic process;GO:0002673 regulation of acute inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P00639-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00727-1", "uniprot_id": [ { "id": "AMPL_BOVIN", "url": "https://www.uniprot.org/uniprot/P00727", "type": "external" } ], "mass": 56289.0, "length": 519, "protein_name": "Cytosol aminopeptidase", "gene_name": "LAP3", "organism": "Bovine", "refseq_name": "cytosol aminopeptidase", "refseq_ac": [ { "id": "NP_776523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776523", "type": "external" } ], "gene_names_uniprotkb": "LAP3", "gene_names_refseq": "LAP-3; LAP3; PEPS", "protein_names_uniprotkb": "Cytosol aminopeptidase; 3.4.11.1; 3.4.11.5; 3.4.13.23; Cysteinylglycine-S-conjugate dipeptidase; LAP-3; LAP; Leucine aminopeptidase 3; Leucyl aminopeptidase; Peptidase S; Proline aminopeptidase; Prolyl aminopeptidase", "protein_names_refseq": "LAP; cysteinylglycine-S-conjugate dipeptidase; cytosol aminopeptidase; leucyl aminopeptidase; peptidase S; proline aminopeptidase; prolyl aminopeptidase", "tax_id": 9913, "disease": "", "pathway": " (bta:781648)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14583094;1548695;16519517;17157838;21110109;21918843;22304649;2395881;7085616;7085617;7578088;7619821;8357796;8369298;8506345", "class_list": "", "function": "Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides (PubMed:14583094, PubMed:16519517). The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme (PubMed:16519517). For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates (PubMed:16519517). Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status (PubMed:14583094)., [UniProtKB, PubMed, PubMed]; In this density functional theory study, reaction mechanisms of a co-catalytic binuclear metal center (Zn1-Zn2) containing enzyme leucine aminopeptidase for two different metal bridging nucleophiles (H(2)O and -OH) have been investigated., [RefSeq, PubMed]; Promoter polymorphism and milk production, [RefSeq, PubMed]; The LAP3 gene possibly contributed to conducting association analysis and can be used as molecular marker in milk production traits and other performance for animal breeding., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2HJH5;Q2PC24", "ec_number_list": [ { "id": "3.4.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.1", "type": "external" }, { "id": "3.4.11.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.5", "type": "external" }, { "id": "3.4.13.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.23", "type": "external" }, { "id": "3.4.13.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.18", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0004180 carboxypeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0008233 peptidase activity;GO:0097718 disordered domain specific binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P00727-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00730-1", "uniprot_id": [ { "id": "CBPA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P00730", "type": "external" } ], "mass": 47082.0, "length": 419, "protein_name": "Carboxypeptidase A1", "gene_name": "CPA1", "organism": "Bovine", "refseq_name": "carboxypeptidase A1 precursor", "refseq_ac": [ { "id": "NP_777175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777175", "type": "external" } ], "gene_names_uniprotkb": "CPA1; CPA", "gene_names_refseq": "CPA1", "protein_names_uniprotkb": "Carboxypeptidase A1; 3.4.17.1", "protein_names_refseq": "carboxypeptidase A1 (pancreatic); carboxypeptidase A1 precursor; pancreatic procarboxypeptidase A", "tax_id": 9913, "disease": "", "pathway": " (bta:286762)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10955996;11937361;12431056;12554943;12729612;15299490;1998496;23746805;3147705;5102489;5143102;5817619;6887246;7556081;8522204;9867434", "class_list": "", "function": "Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity). Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (PubMed:12729612)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.17.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0006691 leukotriene metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P00730-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00745-1", "uniprot_id": [ { "id": "PROC_BOVIN", "url": "https://www.uniprot.org/uniprot/P00745", "type": "external" } ], "mass": 51409.0, "length": 456, "protein_name": "Vitamin K-dependent protein C", "gene_name": "PROC", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PROC", "gene_names_refseq": "", "protein_names_uniprotkb": "Vitamin K-dependent protein C; 3.4.21.69; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "6091100;6304092;6406503;6572939;6896876;6896877", "class_list": "", "function": "Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (By similarity). Exerts a protective effect on the endothelial cell barrier function (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0007596 blood coagulation;GO:0050728 negative regulation of inflammatory response;GO:1903142 positive regulation of establishment of endothelial barrier", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P00745-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00921-1", "uniprot_id": [ { "id": "CAH2_BOVIN", "url": "https://www.uniprot.org/uniprot/P00921", "type": "external" } ], "mass": 29114.0, "length": 260, "protein_name": "Carbonic anhydrase 2", "gene_name": "CA2", "organism": "Bovine", "refseq_name": "carbonic anhydrase 2", "refseq_ac": [ { "id": "NP_848667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848667", "type": "external" } ], "gene_names_uniprotkb": "CA2", "gene_names_refseq": "CA2", "protein_names_uniprotkb": "Carbonic anhydrase 2; 4.2.1.1; 4.2.1.69; CA-II; Carbonate dehydratase II; Carbonic anhydrase II; Cyanamide hydratase CA2", "protein_names_refseq": "CA-II; carbonate dehydratase II; carbonic anhydrase 2; carbonic anhydrase II; cyanamide hydratase CA2", "tax_id": 9913, "disease": "", "pathway": " (bta:280740)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11342547;15039588;16213706;17664347;19093;26093313;26687908;27129464;30640946;32007272;826282", "class_list": "", "function": "A single substitution of the amino acid in three mutant forms of CA II affected the native state of the protein but did not change its unfolding pathway. On the contrary, the inserted disulfide bridge in three other mutant forms of CA II affected the protein unfolding pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Binding of dorzolamide to bovine and human carbonic anhydrase II, [RefSeq, PubMed]; Catalytic activity of CAII affects the SNAT3 conductance, but presumably not by increasing the local H+ buffer capacity, [RefSeq, PubMed]; Catalyzes the reversible hydration of carbon dioxide (By similarity). Can also hydrate cyanamide to urea (By similarity). Involved in the regulation of fluid secretion into the anterior chamber of the eye (By similarity). Essential for bone resorption and osteoclast differentiation (By similarity). Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption (By similarity). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity)., [UniProtKB, UniProtKB]; Increasing the number and distribution of surface acidic groups of CAII is sufficient to function in high-salt environments. Publication Status: Online-Only, [RefSeq, PubMed]; Novel series of mono- and bis- benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II, [RefSeq, PubMed]; Structure refined to 1.95 A resolution; has a C-terminal knot structure; contains one zinc ion in the active site coordinated to 3 his and 1 water molecule; structure reveals a probable alternative proton-wire pathway that differs from that of HCA II., [RefSeq, PubMed]; The presence of cross-beta-structure as a key determinant of carbonic anhydrase amyloid fibrils cytotoxicity., [RefSeq, PubMed]; This study provides the first evidence that extra-platelet nitrite and erythrocytic CAII may modulate platelet function in a cGMP-dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBJ5;Q865Y7", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity;GO:0018820 cyanamide hydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0038166 angiotensin-activated signaling pathway;GO:0015670 carbon dioxide transport;GO:0051453 regulation of intracellular pH;GO:0044070 regulation of monoatomic anion transport;GO:2001150 positive regulation of dipeptide transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P00921-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01045-1", "uniprot_id": [ { "id": "KNG2_BOVIN", "url": "https://www.uniprot.org/uniprot/P01045", "type": "external" } ], "mass": 68710.0, "length": 619, "protein_name": "Kininogen-2", "gene_name": "KNG2", "organism": "Bovine", "refseq_name": "kininogen-1 isoform II precursor", "refseq_ac": [ { "id": "NP_001106748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106748", "type": "external" } ], "gene_names_uniprotkb": "KNG2", "gene_names_refseq": "KNG1; KNG2; KNG", "protein_names_uniprotkb": "Kininogen-2; Kallidin II; Kallidin I; Kininogen II; Thiol proteinase inhibitor", "protein_names_refseq": "bradykinin; kininogen II; kininogen I; kininogen-1 isoform II precursor; kininogen-2; thiol proteinase inhibitor", "tax_id": 9913, "disease": "", "pathway": " (bta:280833)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1169237;12181294;18191860;3546295;4986212;6571699;6572010;956151", "class_list": "", "function": "(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting., [UniProtKB]; Bradykini stimulates endothelial cell fatty acid oxidation by calmodulin-dependent kinase kinase -dependent activation of AMP-activated protein kinase (AMPK), [RefSeq, PubMed]; Bradykinin, together with its precursor and tissue kallikrein, is continuously released into the vasculature of the isolated, perfused, lactating bovine udder., [RefSeq, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 0, "predicted_o_glycosites": 12, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "P01047", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006954 inflammatory response;GO:0007162 negative regulation of cell adhesion;GO:0007596 blood coagulation;GO:0042311 vasodilation;GO:0030195 negative regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P01045-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01175-1", "uniprot_id": [ { "id": "NEU1_BOVIN", "url": "https://www.uniprot.org/uniprot/P01175", "type": "external" } ], "mass": 12665.0, "length": 125, "protein_name": "Oxytocin-neurophysin 1", "gene_name": "OXT", "organism": "Bovine", "refseq_name": "oxytocin-neurophysin 1 preproprotein", "refseq_ac": [ { "id": "NP_789825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789825", "type": "external" } ], "gene_names_uniprotkb": "OXT", "gene_names_refseq": "OT-NPI; OTNPI; OXT", "protein_names_uniprotkb": "Oxytocin-neurophysin 1; OT-NPI; Ocytocin; pro-OXT; pro-oxytocin/neurophysin", "protein_names_refseq": "oxytocin, prepro- (neurophysin I); oxytocin, prepropeptide; oxytocin-neurophysin 1 preproprotein; oxytocin-neurophysin 1; prepro-oxytocin", "tax_id": 9913, "disease": "", "pathway": " (bta:280888); (R-BTA-388479); (R-BTA-416476)", "pathway_count": 3, "publication_count": 29, "publication_id_list": "1150656;11980496;13129273;16128578;1628613;17192588;23971190;24856470;2674120;28163019;2911588;3008332;3275658;3654597;3768139;4008499;4019503;428540;4501123;5094666;6209133;6687626;670174;6709064;7061422;7204368;8564543;9139116;932015", "class_list": "", "function": "Carrier protein that binds to and transports oxytocin from the hypothalamus to the posterior pituitary gland, protecting it from degradation and facilitating its release., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system., [RefSeq, PubMed]; Neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection (By similarity). Released in response to a variety of social cues and acts by binding to oxytocin receptor (OXTR), triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory) (By similarity). Central release (direct secretion in the brain) plays essential roles in social behavior, such as maternal care, social cognition and affiliative behaviors (By similarity). Stressful and anxiogenic stimuli promote release of oxytocin, which acts as a powerful modulator of anxiety- and stress-related behaviors (By similarity). Modulates neural circuits related to reward, fear and social approach, encouraging care and cooperation, but can also increase guilt or aggression towards out-groups (By similarity). Beyond its role in social behavior, plays a role in other processes, such as parturition, lactation or osteoblast differentiation, when released peripherally (secreted from the posterior pituitary gland into the bloodstream) (By similarity). Required for parturition and milk ejection by triggering and strengthening contraction of the smooth muscle of the uterus and mammary gland, respectively (By similarity). Promotes bone mass by stimulating bone formation by osteoblasts (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Oxytocin (OT) mRNA and protein levels were lower in the corpus luteum of pregnancy than in the corpus luteum of the estrous cycle., [RefSeq, PubMed]; Precursor of oxytocin, a neurohypophyseal hormone that plays a key role in social interactions and neurophysin 1, its carrier protein., [UniProtKB, PubMed]; These data suggest that cortisol affects oxytocin synthesis and secretion in bovine ovarian cells, by acting on the expression of key genes, that may impair ovary, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJ78;P01188", "ec_number_list": [], "go_molecular_function": "GO:0005185 neurohypophyseal hormone activity;GO:0031855 oxytocin receptor binding;GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0002125 maternal aggressive behavior;GO:0035556 intracellular signal transduction;GO:0043627 response to estrogen;GO:0070474 positive regulation of uterine smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P01175-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01211-1", "uniprot_id": [ { "id": "PENK_BOVIN", "url": "https://www.uniprot.org/uniprot/P01211", "type": "external" } ], "mass": 29788.0, "length": 263, "protein_name": "Proenkephalin-A", "gene_name": "PENK", "organism": "Bovine", "refseq_name": "proenkephalin-A precursor", "refseq_ac": [ { "id": "NP_776566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776566", "type": "external" } ], "gene_names_uniprotkb": "PENK", "gene_names_refseq": "PENK", "protein_names_uniprotkb": "Proenkephalin-A; BAM(8-22); BAM-20P; BAM-22P; Bovine adrenal medulla peptide 20; Bovine adrenal medulla peptide 22; Bovine adrenal medulla peptide 8-22; OGF; Opioid growth factor", "protein_names_refseq": "proenkephalin-A precursor; proenkephalin-A", "tax_id": 9913, "disease": "", "pathway": " (bta:281387); (R-BTA-375276); (R-BTA-381426); (R-BTA-418594); (R-BTA-8957275)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "12869695;30243794;6173760;6276759;6952189;7213356;8654396", "class_list": "", "function": "Enkelytin possesses antibacterial activity against Gram-positive bacteria such as Micrococcus luteus and Bacillus megaterium., [UniProtKB, PubMed]; Increases glutamate release in the striatum and decreases GABA concentration in the striatum., [UniProtKB, UniProtKB]; Increases glutamate release in the striatum., [UniProtKB, UniProtKB]; Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release., [UniProtKB, UniProtKB]; Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress., [UniProtKB, UniProtKB]; Neuropeptide that induces itch in a histamine-independent manner as well as nociceptive sensations (By similarity). Acts as a ligand for MRGPRX1 receptor in sensory neurons of dorsal root ganglion: MRGPRX1-binding in the peripheral nervous system elicits itch and scratching, while MRGPRX1-binding in the central nervous system dampens chronic pain (By similarity)., [UniProtKB, UniProtKB]; Neuropeptide that mediates stress-induced opioid analgesia (Probable). Also possesses non-opioid action by acting as a ligand for MRGPRX1 receptor to induce itch in a histamine-independent manner (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2T9T4", "ec_number_list": [], "go_molecular_function": "GO:0031628 opioid receptor binding;GO:0001515 opioid peptide activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007268 chemical synaptic transmission;GO:0007600 sensory perception;GO:0019226 transmission of nerve impulse;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P01211-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01317-1", "uniprot_id": [ { "id": "INS_BOVIN", "url": "https://www.uniprot.org/uniprot/P01317", "type": "external" } ], "mass": 11393.0, "length": 105, "protein_name": "Insulin", "gene_name": "INS", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "INS", "gene_names_refseq": "", "protein_names_uniprotkb": "Insulin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "13032079;13249947;14886311;2456452;4928892;5105368;5545080;9141131", "class_list": "", "function": "Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0042802 identical protein binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1903576 response to L-arginine;GO:0010628 positive regulation of gene expression;GO:0032024 positive regulation of insulin secretion;GO:0043066 negative regulation of apoptotic process;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P01317-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02253-1", "uniprot_id": [ { "id": "H12_BOVIN", "url": "https://www.uniprot.org/uniprot/P02253", "type": "external" } ], "mass": 21356.0, "length": 213, "protein_name": "Histone H1.2", "gene_name": "H1-2", "organism": "Bovine", "refseq_name": "histone H1.2", "refseq_ac": [ { "id": "NP_001076894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076894", "type": "external" } ], "gene_names_uniprotkb": "H1-2", "gene_names_refseq": "H1-2; HIST1H1C", "protein_names_uniprotkb": "Histone H1.2; CTL-1", "protein_names_refseq": "CTL-1; histone H1.1; histone H1.2; histone H1d; histone cluster 1, H1c", "tax_id": 9913, "disease": "", "pathway": " (bta:513971)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19393038;3134256;5167020;7204387;8003976", "class_list": "", "function": "Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histone H1-2 is required for the condensation of nucleosome chains into higher-order structured fibers. Histone H1-2 also acts as a histone reader: specifically recognizes and binds histone H3 trimethylated at 'lys-27' (H3K27me3). Histones H1 also promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex, possibly by facilitating restoration of H3K27me3 post-replication. Together with histone H1-3, histone H1-2 acts as a regulator of splicing, most specifically exon skipping and intron retention events: histone H1-2 has a high affinity for exons and regulates splicing by affecting RNA polymerase II (RNAPII) elongation. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KN02", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0061628 histone H3K27me3 reader activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000791 euchromatin;GO:0000792 heterochromatin", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0140718 facultative heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P02253-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02470-1", "uniprot_id": [ { "id": "CRYAA_BOVIN", "url": "https://www.uniprot.org/uniprot/P02470", "type": "external" } ], "mass": 19790.0, "length": 173, "protein_name": "Alpha-crystallin A chain", "gene_name": "CRYAA", "organism": "Bovine", "refseq_name": "alpha-crystallin A chain", "refseq_ac": [ { "id": "NP_776714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776714", "type": "external" } ], "gene_names_uniprotkb": "CRYAA; CRYA1", "gene_names_refseq": "CRYAA", "protein_names_uniprotkb": "Alpha-crystallin A chain", "protein_names_refseq": "alpha-crystallin A chain", "tax_id": 9913, "disease": "", "pathway": " (bta:281718)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "15340146;1687959;1730617;18617508;18683930;19245863;19284785;20146544;2042736;20440841;21158410;21314599;21445944;22556278;23410823;24131013;24760753;25980911;26644245;26656181;29029932;30657688;32038294;3675580;4770792;7912928;8529423", "class_list": "", "function": "Alpha-crystallin is characterized by homogeneous distribution of scattering density in the domains inaccessible for water penetration, [RefSeq, PubMed]; Contributes to the transparency and refractive index of the lens (By similarity). Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions (PubMed:20440841). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity)., [UniProtKB, PubMed, UniProtKB]; Data show that both green and red light wavelengths induce structural changes in betaL-crystalline. Publication Status: Online-Only, [RefSeq, PubMed]; For moderate O-GlcNAcylation on bovine crystalline alpha, the preferred amino acids were Pro > Ala > Gly at position -2, Ala > Thr >Val > Lys > Pro at position -1, and Ala > Gly > Arg > Glu at position +2., [RefSeq, PubMed]; These results show that between pH 7 and 10 the protein undergoes a reversible thermal transition., [RefSeq, PubMed]; We show that proteases with the potential to generate alphaA-66-80 peptide are present in bovine and human lenses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 2, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0032387 negative regulation of intracellular transport;GO:0043066 negative regulation of apoptotic process;GO:0007601 visual perception;GO:0050821 protein stabilization;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P02470-1", "record_type": "protein", "filter_code": "0000000.0010101.100000.010000000000000000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02548-1", "uniprot_id": [ { "id": "NFL_BOVIN", "url": "https://www.uniprot.org/uniprot/P02548", "type": "external" } ], "mass": 62646.0, "length": 555, "protein_name": "Neurofilament light polypeptide", "gene_name": "NEFL", "organism": "Bovine", "refseq_name": "neurofilament light polypeptide", "refseq_ac": [ { "id": "NP_776546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776546", "type": "external" } ], "gene_names_uniprotkb": "NEFL", "gene_names_refseq": "NEFL", "protein_names_uniprotkb": "Neurofilament light polypeptide; 68 kDa neurofilament protein; Micro glutamic acid-rich protein; NF-L; Neurofilament triplet L protein", "protein_names_refseq": "68 kDa neurofilament protein; NF-L; micro glutamic acid-rich protein; neurofilament light polypeptide; neurofilament triplet L protein; neurofilament, light polypeptide 68kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:281348); (R-BTA-438066); (R-BTA-5673001)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "14967049;3884373", "class_list": "", "function": "Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P79127;Q17QQ0", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0015631 tubulin binding;GO:0099184 structural constituent of postsynaptic intermediate filament cytoskeleton", "go_cellular_component": "GO:0030424 axon;GO:0031594 neuromuscular junction;GO:0005882 intermediate filament;GO:1904115 axon cytoplasm;GO:0005883 neurofilament", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0045110 intermediate filament bundle assembly;GO:0050885 neuromuscular process controlling balance;GO:0048812 neuron projection morphogenesis;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P02548-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02638-1", "uniprot_id": [ { "id": "S100B_BOVIN", "url": "https://www.uniprot.org/uniprot/P02638", "type": "external" } ], "mass": 10668.0, "length": 92, "protein_name": "Protein S100-B", "gene_name": "S100B", "organism": "Bovine", "refseq_name": "protein S100-B", "refseq_ac": [ { "id": "NP_001029727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029727", "type": "external" } ], "gene_names_uniprotkb": "S100B", "gene_names_refseq": "S100B", "protein_names_uniprotkb": "Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B", "protein_names_refseq": "S-100 protein beta chain; S-100 protein subunit beta; S100 protein, beta polypeptide; protein S100-B", "tax_id": 9913, "disease": "", "pathway": " (bta:525716); (R-BTA-445989); (R-BTA-879415); (R-BTA-933542)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "14661952;20069545;2039467;21209080;25649061;3722149;4026304;6615778;710399;7250124;8805590", "class_list": "", "function": "As CSF-S100B levels in calves with neurologic diseases widely differed, the utility of CSF-S100B as a diagnostic marker for neurologic diseases in cattle remains inconclusive., [RefSeq, PubMed]; Intracellular S100B might modulate myoblast differentiation by interfering with MyoD expression in an NF-kappaB-dependent manner., [RefSeq, PubMed]; S100B might participate in the pathophysiology of brain inflammatory disorders via RAGE-dependent regulation of several inflammation-related events including activation and migration of microglia, [RefSeq, PubMed]; Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:3722149, PubMed:6615778). Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (PubMed:3722149, PubMed:6615778). Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (PubMed:3722149). Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (By similarity). Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (By similarity). Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (PubMed:14661952). Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity). May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IFR6;Q3ZBY1", "ec_number_list": [], "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0097490 sympathetic neuron projection extension;GO:0006417 regulation of translation;GO:0007155 cell adhesion;GO:0007409 axonogenesis;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P02638-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02639-1", "uniprot_id": [ { "id": "S10A1_BOVIN", "url": "https://www.uniprot.org/uniprot/P02639", "type": "external" } ], "mass": 10518.0, "length": 94, "protein_name": "Protein S100-A1", "gene_name": "S100A1", "organism": "Bovine", "refseq_name": "protein S100-A1", "refseq_ac": [ { "id": "NP_001092512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092512", "type": "external" } ], "gene_names_uniprotkb": "S100A1", "gene_names_refseq": "S100A1", "protein_names_uniprotkb": "Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1", "protein_names_refseq": "protein S100-A1", "tax_id": 9913, "disease": "", "pathway": " (bta:528735); (R-BTA-5686938)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14638689;15885104;18088104;3755105;6615778;7250124", "class_list": "", "function": "Beta-mercaptoethanol modification of apo-S100A1 makes its structure more similar to that of holo-S100A1, so that it becomes much better adjusted for calcium coordination., [RefSeq, PubMed]; Identified S100A1, but not calmodulin or other S100 proteins, as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex (S100A1), [RefSeq, PubMed]; Results suggest that S100A1 can act as a linker between the calcium and redox signalling pathways., [RefSeq, PubMed]; Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJ73", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0051117 ATPase binding;GO:0005509 calcium ion binding;GO:0044548 S100 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0042311 vasodilation;GO:0008016 regulation of heart contraction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P02639-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02668-1", "uniprot_id": [ { "id": "CASK_BOVIN", "url": "https://www.uniprot.org/uniprot/P02668", "type": "external" } ], "mass": 21269.0, "length": 190, "protein_name": "Kappa-casein", "gene_name": "CSN3", "organism": "Bovine", "refseq_name": "kappa-casein precursor", "refseq_ac": [ { "id": "NP_776719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776719", "type": "external" } ], "gene_names_uniprotkb": "CSN3; CSN10; CSNK", "gene_names_refseq": "CSN10; CSN3K; CSN3; CSNK", "protein_names_uniprotkb": "Kappa-casein", "protein_names_refseq": "casoplatelin; casoxin C; k-casein; kappa-casein precursor; kappa-casein; milk protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281728)", "pathway_count": 1, "publication_count": 37, "publication_id_list": "10654430;11529896;12170271;15771744;1628650;1683188;18186809;21211944;22092935;22614274;23662732;25456591;26173981;2760302;28850632;32069518;3208764;34019948;3582972;3732274;37604312;427192;4407313;4577852;4653404;6328443;6689612;6897774;7225429;7308473;7317452;7397215;7408862;7734846;8161175;8817876;8930077", "class_list": "", "function": "A meta-analysis on association between CSN3 gene variants and milk yield and composition in cattle., [RefSeq, PubMed]; Casoplatelin inhibits platelet aggregation., [UniProtKB]; Casoxins A, B and C have opioid antagonist activity. Casoxin C causes biphasic ileal contractions through the binding to the complement C3a receptors., [UniProtKB]; It was concluded that GH or IGF-I can independently promote the expression of CSN3 in bovine mammary epithelial cells in vitro., [RefSeq, PubMed]; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk., [UniProtKB]; Statistical analysis established that the CSN3 gene has no statistically significant influence on daily milk, fat and protein yield and SCC Publication Status: Online-Only, [RefSeq, PubMed]; The influence of CSN3 genotype on milk production and chemical composition in Romanian Simmental cattle, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 8, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 9, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 21, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "O46566;Q597F3;Q6U205;Q9N271;Q9TRQ3;Q9TV96;Q9TV97", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0035375 zymogen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen", "go_biological_process": "GO:0032570 response to progesterone;GO:0050821 protein stabilization;GO:0032355 response to estradiol;GO:0007595 lactation;GO:1903494 response to dehydroepiandrosterone", "synthesized_glycan_count": 0, "hit_score": 6.8, "record_id": "P02668-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02672-1", "uniprot_id": [ { "id": "FIBA_BOVIN", "url": "https://www.uniprot.org/uniprot/P02672", "type": "external" } ], "mass": 67012.0, "length": 615, "protein_name": "Fibrinogen alpha chain", "gene_name": "FGA", "organism": "Bovine", "refseq_name": "fibrinogen alpha chain precursor", "refseq_ac": [ { "id": "NP_001028798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028798", "type": "external" } ], "gene_names_uniprotkb": "FGA", "gene_names_refseq": "FGA", "protein_names_uniprotkb": "Fibrinogen alpha chain", "protein_names_refseq": "A-alpha fibrinogen; fibrinogen A-alpha chain; fibrinogen alpha chain precursor; fibrinogen, alpha polypeptide", "tax_id": 9913, "disease": "", "pathway": " (bta:522039)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10618375;12648094;13823737;16475814;17590019;19928926;26910190;434821;836881", "class_list": "", "function": "Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways., [UniProtKB, UniProtKB]; Full-length bovine alphaC-domain, bAalpha374-568, and its human counterpart, hAalpha392-610, can form ordered oligomers in a similar manner., [RefSeq, PubMed]; NMR solution structure of the bovine fibrinogen alphaC-domain fragment, including residues Aalpha374-538, reveals a type-I' beta-hairpin, restricted at the base by a C423-C453 disulfide linkage and a short turn preceding C423. Erratum:[Biochemistry. 2007 Jun 5;46(22):6674], [RefSeq, PubMed]; The complete NMR solution structure of the Aalpha406-483 alphaC-domain fragment, provide direct evidence for the intra- and intermolecular interactions between the alphaC-domains, and confirm that these interactions are thermodynamically driven., [RefSeq, PubMed]; Two different approaches to tune the fibrillar structure and mechanical properties of fibrin hydrogels, are reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O97642;Q3T049", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005577 fibrinogen complex", "go_biological_process": "GO:0045087 innate immune response;GO:0042730 fibrinolysis;GO:0002250 adaptive immune response;GO:0070527 platelet aggregation;GO:0051258 protein polymerization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P02672-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02687-1", "uniprot_id": [ { "id": "MBP_BOVIN", "url": "https://www.uniprot.org/uniprot/P02687", "type": "external" } ], "mass": 18323.0, "length": 169, "protein_name": "Myelin basic protein", "gene_name": "MBP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MBP", "gene_names_refseq": "", "protein_names_uniprotkb": "Myelin basic protein; 20 kDa microtubule-stabilizing protein; MBP; Myelin A1 protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 27, "publication_id_list": "1281825;1382581;1700979;22420465;23828821;2416809;2418380;2419434;2430996;2466871;2582288;4129204;4994464;5033419;5096093;5442707;57115;6083471;6155143;6174544;6177712;6183342;6209588;68996;7515900;8530487;9485392", "class_list": "", "function": "Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9BGM8;Q9TS63;Q9TSA6", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath;GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0033269 internode region of axon;GO:0043025 neuronal cell body;GO:0043209 myelin sheath;GO:0071944 cell periphery;GO:0032991 protein-containing complex", "go_biological_process": "GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P02687-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02690-1", "uniprot_id": [ { "id": "MYP2_BOVIN", "url": "https://www.uniprot.org/uniprot/P02690", "type": "external" } ], "mass": 14950.0, "length": 132, "protein_name": "Myelin P2 protein", "gene_name": "PMP2", "organism": "Bovine", "refseq_name": "myelin P2 protein", "refseq_ac": [ { "id": "NP_001068707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068707", "type": "external" } ], "gene_names_uniprotkb": "PMP2", "gene_names_refseq": "PMP2", "protein_names_uniprotkb": "Myelin P2 protein", "protein_names_refseq": "myelin P2 protein", "tax_id": 9913, "disease": "", "pathway": " (bta:506062)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12161025;1692033;2458918;2463999;6156092;7683727", "class_list": "", "function": "May play a role in lipid transport protein in Schwann cells. May bind cholesterol., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VCJ4", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0061024 membrane organization;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P02690-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02698-1", "uniprot_id": [ { "id": "GBG1_BOVIN", "url": "https://www.uniprot.org/uniprot/P02698", "type": "external" } ], "mass": 8544.0, "length": 74, "protein_name": "Guanine nucleotide-binding protein G(T) subunit gamma-T1", "gene_name": "GNGT1", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(T) subunit gamma-T1", "refseq_ac": [ { "id": "NP_776752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776752", "type": "external" } ], "gene_names_uniprotkb": "GNGT1", "gene_names_refseq": "GNGT1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(T) subunit gamma-T1; Transducin gamma chain", "protein_names_refseq": "guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1; guanine nucleotide-binding protein G(T) subunit gamma-T1; transducin gamma chain", "tax_id": 9913, "disease": "", "pathway": " (bta:281796); (R-BTA-1296041); (R-BTA-202040); (R-BTA-2485179); (R-BTA-2514859); (R-BTA-381676); (R-BTA-392170); (R-BTA-392451); (R-BTA-392851); (R-BTA-400042); (R-BTA-4086398); (R-BTA-416476); (R-BTA-416482); (R-BTA-418217); (R-BTA-418555); (R-BTA-418592); (R-BTA-418594); (R-BTA-418597); (R-BTA-420092); (R-BTA-428930); (R-BTA-432040); (R-BTA-456926); (R-BTA-500657); (R-BTA-6814122); (R-BTA-8964315); (R-BTA-8964616); (R-BTA-9009391); (R-BTA-9856530); (R-BTA-997272)", "pathway_count": 29, "publication_count": 11, "publication_id_list": "1903391;2217200;2385292;27088923;2984674;3917402;6149748;6438626;8500562;8552196;9739091", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]; The PIP2-induced orientation of the GRK2-Gbeta1gamma2 complex is therefore most likely caused by specific interactions between PIP2 and the GRK2 PH domain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0097381 photoreceptor disc membrane;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P02698-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02699-1", "uniprot_id": [ { "id": "OPSD_BOVIN", "url": "https://www.uniprot.org/uniprot/P02699", "type": "external" } ], "mass": 39008.0, "length": 348, "protein_name": "Rhodopsin", "gene_name": "RHO", "organism": "Bovine", "refseq_name": "rhodopsin", "refseq_ac": [ { "id": "NP_001014890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014890", "type": "external" } ], "gene_names_uniprotkb": "RHO", "gene_names_refseq": "RHO", "protein_names_uniprotkb": "Rhodopsin", "protein_names_refseq": "rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant); rhodopsin", "tax_id": 9913, "disease": "", "pathway": " (bta:509933); (R-BTA-2453902); (R-BTA-2485179); (R-BTA-2514859); (R-BTA-418594); (R-BTA-419771); (R-BTA-5620916)", "pathway_count": 7, "publication_count": 59, "publication_id_list": "10888202;10926528;10930473;11425302;11570894;11972040;12044163;1396673;15111114;1512231;1521467;15327956;15351781;15491621;16586416;16908857;17020884;17060607;17449675;17825322;18563085;18645239;18818650;1913836;2006550;21389983;2145276;22198838;23303210;23579341;2457026;25205354;25673879;26200343;26526852;27458239;27509380;28655769;2950966;31251171;31300275;32060349;32795534;3350146;33809708;34997336;447724;468821;6194890;6228228;6529569;6759163;6870827;7578070;9099669;9298947;9405601;9492758;9541408", "class_list": "", "function": "Conformational perturbation, allosteric modulation of cellular signaling pathways, and disease in P23H rhodopsin. Publication Status: Online-Only, [RefSeq, PubMed]; Disruption of Hydrogen-Bond Network in Rhodopsin Mutations Cause Night Blindness., [RefSeq, PubMed]; G protein-coupled photoreceptor that activates the G protein transducin (t) signaling pathway in response to light and is essential for image-forming vision under low-light conditions (PubMed:31300275). Required for postnatal photoreceptor cell viability (By similarity). Activation occurs when the covalently bound 11-cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers G protein-mediated phototransduction (Probable) (PubMed:16586416, PubMed:16908857, PubMed:17060607, PubMed:17449675, PubMed:18818650, PubMed:21389983, PubMed:22198838, PubMed:23579341, PubMed:25205354, PubMed:27458239, PubMed:31300275). Signal termination occurs via receptor phosphorylation, which promotes binding of arrestin (SAG) and displacement of the G protein alpha subunit (Probable) (PubMed:1396673)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations. Publication Status: Online-Only, [RefSeq, PubMed]; Simple Models to Study Spectral Properties of Microbial and Animal Rhodopsins: Evaluation of the Electrostatic Effect of Charged and Polar Residues on the First Absorption Band Maxima. Publication Status: Online-Only, [RefSeq, PubMed]; The density map reveals the receptor C-terminal tail bound to the Gbeta subunit of the G protein, providing a structural foundation for the role of the C-terminal tail in GPCR signaling, and of Gbeta as scaffold for recruiting Galpha subunits and G protein-receptor kinases. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 6, "reported_phosphosites": 7, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:1990763 arrestin family protein binding;GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0060342 photoreceptor inner segment membrane;GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007603 phototransduction, visible light;GO:0009416 response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 7.2, "record_id": "P02699-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02722-1", "uniprot_id": [ { "id": "ADT1_BOVIN", "url": "https://www.uniprot.org/uniprot/P02722", "type": "external" } ], "mass": 32967.0, "length": 298, "protein_name": "ADP/ATP translocase 1", "gene_name": "SLC25A4", "organism": "Bovine", "refseq_name": "ADP/ATP translocase 1", "refseq_ac": [ { "id": "NP_777083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777083", "type": "external" } ], "gene_names_uniprotkb": "SLC25A4; AAC1; ANT1", "gene_names_refseq": "ANT1; SLC25A4", "protein_names_uniprotkb": "ADP/ATP translocase 1; ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart isoform T1; ANT 1; Adenine nucleotide translocator 1; Solute carrier family 25 member 4", "protein_names_refseq": "ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart; ADP/ATP carrier; ADP/ATP translocase 1; ADP/ATP translocase T1; ANT 1; adenine nucleotide translocator 1 (skeletal muscle)", "tax_id": 9913, "disease": "", "pathway": " (bta:282478); (R-BTA-1268020); (R-BTA-166187); (R-BTA-83936)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "14603310;16226253;19902971;2540808;27786441;28100784;3017341;7076130;7961643", "class_list": "", "function": "ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (PubMed:7961643). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (PubMed:7961643). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (By similarity). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Crystal form of ADP/ATP carrier obtained in the presence of carboxyatractyloside was analysed., [RefSeq, PubMed]; Data show that the binding sites on adenine nucleotide translocator 1 (ANT1) have an affinity for cardiolipin (CL)., [RefSeq, PubMed]; Phosphatidic acid and cardiolipin interact with the mitochondrial ADP/ATP carrier., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005471 ATP:ADP antiporter activity;GO:0017077 oxidative phosphorylation uncoupler activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0005757 mitochondrial permeability transition pore complex", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0046902 regulation of mitochondrial membrane permeability;GO:0015866 ADP transport;GO:1990845 adaptive thermogenesis;GO:0140021 mitochondrial ADP transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P02722-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02769-1", "uniprot_id": [ { "id": "ALBU_BOVIN", "url": "https://www.uniprot.org/uniprot/P02769", "type": "external" } ], "mass": 69293.0, "length": 607, "protein_name": "Albumin", "gene_name": "ALB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ALB", "gene_names_refseq": "", "protein_names_uniprotkb": "Albumin; BSA", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:280717)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "10233671;10586096;11034420;11298124;11801660;12054661;12645954;12648094;15565337;1656276;20934997;21565706;2260975;22677715;22993082;23769932;2379503;2437111;2474609;24753230;26495903;30573663;3389500;34019948;37217939;37604312;41018975;488109;6234017;7283978;843354", "class_list": "", "function": "Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (PubMed:22677715). The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (Probable). The rank order of affinity is zinc > calcium > magnesium (Probable). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 1, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJX3;O02787;P04277;Q3SZR2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005504 fatty acid binding;GO:0015643 toxic substance binding;GO:0030170 pyridoxal phosphate binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0031667 response to nutrient levels;GO:0009267 cellular response to starvation;GO:0051902 negative regulation of mitochondrial depolarization;GO:0072732 cellular response to calcium ion starvation", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P02769-1", "record_type": "protein", "filter_code": "0000000.0010101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02820-1", "uniprot_id": [ { "id": "OSTCN_BOVIN", "url": "https://www.uniprot.org/uniprot/P02820", "type": "external" } ], "mass": 11042.0, "length": 100, "protein_name": "Osteocalcin", "gene_name": "BGLAP", "organism": "Bovine", "refseq_name": "osteocalcin preproprotein", "refseq_ac": [ { "id": "NP_776674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776674", "type": "external" } ], "gene_names_uniprotkb": "BGLAP", "gene_names_refseq": "BGLAP; BGP", "protein_names_uniprotkb": "Osteocalcin; BGP; Bone Gla protein; Gamma-carboxyglutamic acid-containing protein", "protein_names_refseq": "bone Gla protein; gamma-carboxyglutamic acid-containing protein; osteocalcin preproprotein; osteocalcin", "tax_id": 9913, "disease": "", "pathway": " (bta:281646)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1068450;12820886;14970229;18793762;21300389;2336375;24138653;25316140", "class_list": "", "function": "A molecular mechanism of lead toxicity for calcium binding proteins., [RefSeq, PubMed]; Data suggest that helical content of 3 Glu-OCN is 57% and is independent of calcium binding; 3 Glu-OCN contains 3 alpha-helices around a hydrophobic core; study includes first high-resolution structure of bovine 3 Glu-OCN using X-ray crystallography., [RefSeq, PubMed]; Osteocalcin is released from the bone matrix during bone resorption as intact molecules and fragments; serum osteocalcin should be considered as a marker of bone turnover rather than bone formation, [RefSeq, PubMed]; Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells., [RefSeq, PubMed]; Serum osteocalcin levels in non-periparturient Holstein dairy cows were highest in the youngest cows, decreasing with age until time of first calving. In periparturient cows, serum osteocalcin levels were higher in primiparous than in multiparous cows., [RefSeq, PubMed]; The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (PubMed:1068450). Acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (By similarity). Binds strongly to apatite and calcium upon gamma-carboxylation; this modification is essential for bone metabolism (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7YEW1", "ec_number_list": [], "go_molecular_function": "GO:0008147 structural constituent of bone;GO:0005509 calcium ion binding;GO:0005179 hormone activity;GO:0046848 hydroxyapatite binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:1900076 regulation of cellular response to insulin stimulus;GO:1903011 negative regulation of bone development;GO:0007611 learning or memory;GO:0032869 cellular response to insulin stimulus;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P02820-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03887-1", "uniprot_id": [ { "id": "NU1M_BOVIN", "url": "https://www.uniprot.org/uniprot/P03887", "type": "external" } ], "mass": 35670.0, "length": 318, "protein_name": "NADH-ubiquinone oxidoreductase chain 1", "gene_name": "MT-ND1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MT-ND1; MTND1; NADH1; ND1", "gene_names_refseq": "", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 1; 7.1.1.2; NADH dehydrogenase subunit 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "17060615;25209663;3141400;7120390", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:3141400). Essential for the catalytic activity of complex I (PubMed:3141400). Essential for the assembly of complex I (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P03887-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03892-1", "uniprot_id": [ { "id": "NU2M_BOVIN", "url": "https://www.uniprot.org/uniprot/P03892", "type": "external" } ], "mass": 39254.0, "length": 347, "protein_name": "NADH-ubiquinone oxidoreductase chain 2", "gene_name": "MT-ND2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MT-ND2; MTND2; NADH2; ND2", "gene_names_refseq": "", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 2; 7.1.1.2; NADH dehydrogenase subunit 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "17060615;25209663;7120390", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SFW9", "ec_number_list": [ { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P03892-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03898-1", "uniprot_id": [ { "id": "NU3M_BOVIN", "url": "https://www.uniprot.org/uniprot/P03898", "type": "external" } ], "mass": 13055.0, "length": 115, "protein_name": "NADH-ubiquinone oxidoreductase chain 3", "gene_name": "MT-ND3", "organism": "Bovine", "refseq_name": "NADH dehydrogenase subunit 3", "refseq_ac": [ { "id": "YP_209212", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209212", "type": "external" } ], "gene_names_uniprotkb": "MT-ND3; MTND3; NADH3; ND3", "gene_names_refseq": "ND3", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 3; 7.1.1.2; NADH dehydrogenase subunit 3", "protein_names_refseq": "NADH dehydrogenase subunit 3", "tax_id": 9913, "disease": "", "pathway": " (bta:3283884); (R-BTA-5419276); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "17060615;25209663;7120390", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SEI7", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P03898-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03902-1", "uniprot_id": [ { "id": "NU4LM_BOVIN", "url": "https://www.uniprot.org/uniprot/P03902", "type": "external" } ], "mass": 10797.0, "length": 98, "protein_name": "NADH-ubiquinone oxidoreductase chain 4L", "gene_name": "MT-ND4L", "organism": "Bovine", "refseq_name": "NADH dehydrogenase subunit 4L", "refseq_ac": [ { "id": "YP_209213", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209213", "type": "external" } ], "gene_names_uniprotkb": "MT-ND4L; MTND4L; NADH4L; ND4L", "gene_names_refseq": "ND4L", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 4L; 7.1.1.2; NADH dehydrogenase subunit 4L", "protein_names_refseq": "NADH dehydrogenase subunit 4L", "tax_id": 9913, "disease": "", "pathway": " (bta:3283885); (R-BTA-5419276)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17060615;18721790;25209663;7120390", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:18721790, PubMed:25209663). Part of the enzyme membrane arm which is embedded in the lipid bilayer and involved in proton translocation (PubMed:18721790, PubMed:25209663)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SFX7", "ec_number_list": [ { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042773 ATP synthesis coupled electron transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P03902-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03910-1", "uniprot_id": [ { "id": "NU4M_BOVIN", "url": "https://www.uniprot.org/uniprot/P03910", "type": "external" } ], "mass": 52099.0, "length": 459, "protein_name": "NADH-ubiquinone oxidoreductase chain 4", "gene_name": "MT-ND4", "organism": "Bovine", "refseq_name": "NADH dehydrogenase subunit 4", "refseq_ac": [ { "id": "YP_209214", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209214", "type": "external" } ], "gene_names_uniprotkb": "MT-ND4; MTND4; NADH4; ND4", "gene_names_refseq": "ND4", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 4; 7.1.1.2; NADH dehydrogenase subunit 4", "protein_names_refseq": "NADH dehydrogenase subunit 4", "tax_id": 9913, "disease": "", "pathway": " (bta:3283886); (R-BTA-5419276); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "17060615;25209663;7120390", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SE30", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0009060 aerobic respiration;GO:0015990 electron transport coupled proton transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P03910-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03920-1", "uniprot_id": [ { "id": "NU5M_BOVIN", "url": "https://www.uniprot.org/uniprot/P03920", "type": "external" } ], "mass": 68286.0, "length": 606, "protein_name": "NADH-ubiquinone oxidoreductase chain 5", "gene_name": "MT-ND5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MT-ND5; MTND5; NADH5; ND5", "gene_names_refseq": "", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 5; 7.1.1.2; NADH dehydrogenase subunit 5", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "17060615;25209663;7120390", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8SEN2;Q8SFW8", "ec_number_list": [ { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0015990 electron transport coupled proton transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P03920-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04695-1", "uniprot_id": [ { "id": "GNAT1_BOVIN", "url": "https://www.uniprot.org/uniprot/P04695", "type": "external" } ], "mass": 39966.0, "length": 350, "protein_name": "Guanine nucleotide-binding protein G(t) subunit alpha-1", "gene_name": "GNAT1", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(t) subunit alpha-1", "refseq_ac": [ { "id": "NP_851365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851365", "type": "external" } ], "gene_names_uniprotkb": "GNAT1", "gene_names_refseq": "GNAT1; HG1F", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(t) subunit alpha-1; 3.6.5.-; Transducin alpha-1 chain", "protein_names_refseq": "guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; guanine nucleotide-binding protein G(t) subunit alpha-1; heterotrimeric guanine nucleotide-binding protein 1F; transducin alpha-1 chain", "tax_id": 9913, "disease": "", "pathway": " (bta:281794); (R-BTA-2485179); (R-BTA-2514859); (R-BTA-418594)", "pathway_count": 4, "publication_count": 22, "publication_id_list": "11234020;1436039;16469737;18818650;21285355;21389983;21389988;23303210;23579341;2409555;24375403;28655769;2989813;31300275;33007200;38159849;3867352;3923359;7969474;8208289;8259210;9539726", "class_list": "", "function": "Alpha subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) that transduces signals from the G protein-coupled photoreceptor rhodopsin (RHO) (PubMed:21285355, PubMed:23303210, PubMed:28655769, PubMed:8259210, PubMed:31300275). Required for normal RHO-mediated light perception in retinal rod photoreceptors (By similarity). Functions as a GTPase that contains the guanine nucleotide binding site and cycles between an active GTP-bound state and an inactive GDP-bound state (PubMed:21285355, PubMed:28655769, PubMed:7969474, PubMed:8208289, PubMed:8259210, PubMed:16469737). Under dim light conditions, RHO promotes GDP release and GTP binding (PubMed:21285355, PubMed:28655769). Activates downstream effectors, including cone cGMP-phosphodiesterase (PDE6), to mediate the phototransduction cascade (PubMed:16469737, PubMed:21285355, PubMed:31300275, PubMed:33007200). Stimulates PDE6 by binding and repositioning the PDE6 gamma inhibitory subunits (PDE6G) to promote catalytic activity (PubMed:31300275, PubMed:33007200)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Data suggest that a hetero-multimer complex forms between light-activated rhodopsin and light-activated heterotrimeric transducin (T-alpha-1, Gnb1, Gngt1); the stoichiometry is 1:1 rhodopsin:transducin. The complex appears to form on native rod outer segment membranes upon light activation., [RefSeq, PubMed]; Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6. Erratum:[Mol Cell. 2021 Jun 3;81(11):2496. doi: 10.1016/j.molcel.2021.05.006. PMID: 34087182], [RefSeq, PubMed]; These results indicated that efficient Gt activation by rhodopsin, resulting from an optimized active state of rhodopsin, is one of the causes of the high amplification efficiency of rods., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.4.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.18", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.1.97", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.97", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0097381 photoreceptor disc membrane;GO:0001917 photoreceptor inner segment;GO:0005834 heterotrimeric G-protein complex;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007603 phototransduction, visible light;GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity;GO:0009416 response to light stimulus;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P04695-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08165-1", "uniprot_id": [ { "id": "ADRO_BOVIN", "url": "https://www.uniprot.org/uniprot/P08165", "type": "external" } ], "mass": 54338.0, "length": 492, "protein_name": "NADPH:adrenodoxin oxidoreductase, mitochondrial", "gene_name": "FDXR", "organism": "Bovine", "refseq_name": "NADPH:adrenodoxin oxidoreductase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_777116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777116", "type": "external" } ], "gene_names_uniprotkb": "FDXR; ADXR", "gene_names_refseq": "AR; AdR; FDXR", "protein_names_uniprotkb": "NADPH:adrenodoxin oxidoreductase, mitochondrial; 1.18.1.6; AR; Adrenodoxin reductase; Ferredoxin reductase; Ferredoxin--NADP(+) reductase", "protein_names_refseq": "NADPH:adrenodoxin oxidoreductase, mitochondrial precursor; NADPH:adrenodoxin oxidoreductase, mitochondrial; adrenodoxin reductase; ferredoxin--NADP(+) reductase", "tax_id": 9913, "disease": "", "pathway": " (bta:282604)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10369776;10998235;11053423;16305752;17885803;28799023;2924777;3011431;3038094;3355838;3448086;3691502;7811729;8130767", "class_list": "", "function": "S. pombe is either very robust to mitochondrial reactive oxygen species (ROS) production or does not undergo apoptotic cell death in response to mitochondrial ROS at all., [RefSeq, PubMed]; Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver (PubMed:7811729). Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6 (By similarity)., [UniProtKB, PubMed, UniProtKB]; We constructed cDNA including genes of the bovine cholesterol hydroxylase/lyase (CHL) system proteins-cytochrome P450scc (CYP11A1), adrenodoxin (Adx) and adrenodoxin reductase (AdR), that are fused into a single ORF using FMDV 2A nucleotide sequences., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58CY0;Q95KN8", "ec_number_list": [ { "id": "1.18.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.18.1.6", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0004324 ferredoxin-NADP+ reductase activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0006694 steroid biosynthetic process;GO:0006744 ubiquinone biosynthetic process;GO:0022900 electron transport chain", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P08165-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33072-1", "uniprot_id": [ { "id": "LYOX_BOVIN", "url": "https://www.uniprot.org/uniprot/P33072", "type": "external" } ], "mass": 47115.0, "length": 418, "protein_name": "Protein-lysine 6-oxidase", "gene_name": "LOX", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOX", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein-lysine 6-oxidase; 1.4.3.13; Lysyl oxidase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "11684696;1973052;21188434;31152061;8688089", "class_list": "", "function": "Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q95L38", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" } ], "go_molecular_function": "GO:0005518 collagen binding;GO:0005507 copper ion binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0048514 blood vessel morphogenesis;GO:0035791 platelet-derived growth factor receptor-beta signaling pathway;GO:0018057 peptidyl-lysine oxidation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P33072-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9GL77-1", "uniprot_id": [ { "id": "S4A4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9GL77", "type": "external" } ], "mass": 121331.0, "length": 1079, "protein_name": "Electrogenic sodium bicarbonate cotransporter 1", "gene_name": "SLC4A4", "organism": "Bovine", "refseq_name": "electrogenic sodium bicarbonate cotransporter 1", "refseq_ac": [ { "id": "NP_777030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777030", "type": "external" } ], "gene_names_uniprotkb": "SLC4A4; NBCE1; NBC", "gene_names_refseq": "NBC1; SLC4A4", "protein_names_uniprotkb": "Electrogenic sodium bicarbonate cotransporter 1; Sodium bicarbonate cotransporter; Solute carrier family 4 member 4", "protein_names_refseq": "electrogenic sodium bicarbonate cotransporter 1; sodium bicarbonate cotransporter; solute carrier family 4, sodium bicarbonate cotransporter, member 4", "tax_id": 9913, "disease": "", "pathway": " (bta:282360)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11029313;12604466;15548570;18762166;22771795;24472682", "class_list": "", "function": "AHCYL2 is a potential regulator of NBCe1-B in mammalian cells., [RefSeq, PubMed]; Data indicate that NBC1 (1Na(+)-3HCO(3)(-) cotransporter) plays a key role in transendothelial bicarbonate ion flux and is functional only at the basolateral membrane., [RefSeq, PubMed]; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH., [UniProtKB, PubMed]; These results suggest that IRBIT may reduce the apparent affinity for Mg(2+)(i) in inhibition of NBCe1-B activity in mammalian cells., [RefSeq, PubMed]; These results suggest that Mg2+ may be a cytosolic factor that limits intrinsic cotransport activity of NBCe1-B in mammalian cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0008510 sodium:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006814 sodium ion transport;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9GL77-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95142-1", "uniprot_id": [ { "id": "PDE6D_BOVIN", "url": "https://www.uniprot.org/uniprot/Q95142", "type": "external" } ], "mass": 17390.0, "length": 150, "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "organism": "Bovine", "refseq_name": "retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "refseq_ac": [ { "id": "NP_776845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776845", "type": "external" } ], "gene_names_uniprotkb": "PDE6D", "gene_names_refseq": "PDE6D", "protein_names_uniprotkb": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; GMP-PDE delta", "protein_names_refseq": "GMP-PDE delta; phosphodiesterase 6D, cGMP-specific, rod, delta; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "tax_id": 9913, "disease": "", "pathway": " (bta:281976); (R-BTA-5624958); (R-BTA-9648002)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "14561760;21978030;29311697;30228185;8798640", "class_list": "", "function": "PDEdelta functions as a prenyl-binding protein interacting with multiple prenylated proteins in retinal rods., [RefSeq, PubMed]; Promotes the release of prenylated target proteins from cellular membranes (PubMed:8798640). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Required for RAB28 localization to the cone cell outer segments in the retina (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate., [UniProtKB, UniProtKB, UniProtKB]; Results suggest that PrBP/delta exclusively interacts with the soluble fraction of PDE6. Publication Status: Online-Only, [RefSeq, PubMed]; The modest levels of basal activity exhibited by PDE6 purified from bovine rod outer segments (ROS) indicate that the inhibitory gamma subunit of PDE6 may not be tightly bound to PDE6 catalytic sites., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005095 GTPase inhibitor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030659 cytoplasmic vesicle membrane;GO:0031410 cytoplasmic vesicle;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q95142-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T040-1", "uniprot_id": [ { "id": "RT07_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T040", "type": "external" } ], "mass": 28130.0, "length": 242, "protein_name": "Small ribosomal subunit protein uS7m", "gene_name": "MRPS7", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein uS7m precursor", "refseq_ac": [ { "id": "NP_001029515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029515", "type": "external" } ], "gene_names_uniprotkb": "MRPS7", "gene_names_refseq": "MRPS7", "protein_names_uniprotkb": "Small ribosomal subunit protein uS7m; 28S ribosomal protein S7, mitochondrial; MRP-S7; S7mt", "protein_names_refseq": "28S ribosomal protein S7, mitochondrial; MRP-S7; S7mt; small ribosomal subunit protein uS7m precursor; small ribosomal subunit protein uS7m", "tax_id": 9913, "disease": "", "pathway": " (bta:509115); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10581179;11402041;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3T040-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZCG2-1", "uniprot_id": [ { "id": "MPC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3ZCG2", "type": "external" } ], "mass": 12389.0, "length": 109, "protein_name": "Mitochondrial pyruvate carrier 1", "gene_name": "MPC1", "organism": "Bovine", "refseq_name": "mitochondrial pyruvate carrier 1", "refseq_ac": [ { "id": "NP_001070510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070510", "type": "external" } ], "gene_names_uniprotkb": "MPC1; BRP44L", "gene_names_refseq": "BRP44L; MPC1", "protein_names_uniprotkb": "Mitochondrial pyruvate carrier 1; Brain protein 44-like protein", "protein_names_refseq": "brain protein 44-like protein; mitochondrial pyruvate carrier 1", "tax_id": 9913, "disease": "", "pathway": " (bta:767977)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17060615", "class_list": "", "function": "Mediates the uptake of pyruvate into mitochondria to maintain the balance between glycolysis and oxidative phosphorylation (By similarity). Plays an essential role in cellular metabolism (By similarity)., [UniProtKB, UniProtKB]; Mediates the uptake of pyruvate into mitochondria., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050833 pyruvate transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006850 pyruvate import into mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3ZCG2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58D62-1", "uniprot_id": [ { "id": "FETUB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q58D62", "type": "external" } ], "mass": 42663.0, "length": 387, "protein_name": "Fetuin-B", "gene_name": "FETUB", "organism": "Bovine", "refseq_name": "fetuin-B precursor", "refseq_ac": [ { "id": "NP_001029390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029390", "type": "external" } ], "gene_names_uniprotkb": "FETUB", "gene_names_refseq": "FETUB", "protein_names_uniprotkb": "Fetuin-B", "protein_names_refseq": "fetuin-B precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:504615)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16305752;19674964;24279413", "class_list": "", "function": "Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 1128, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0007338 single fertilization;GO:0010951 negative regulation of endopeptidase activity;GO:0060255 regulation of macromolecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q58D62-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T052-1", "uniprot_id": [ { "id": "ITIH4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T052", "type": "external" } ], "mass": 101513.0, "length": 916, "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H4", "gene_name": "ITIH4", "organism": "Bovine", "refseq_name": "inter-alpha-trypsin inhibitor heavy chain H4 precursor", "refseq_ac": [ { "id": "NP_001015590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015590", "type": "external" } ], "gene_names_uniprotkb": "ITIH4", "gene_names_refseq": "ITIH4", "protein_names_uniprotkb": "Inter-alpha-trypsin inhibitor heavy chain H4; ITI heavy chain H4; ITI-HC4; Inter-alpha-inhibitor heavy chain 4", "protein_names_refseq": "ITI heavy chain H4; ITI-HC4; inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein); inter-alpha-inhibitor heavy chain 4; inter-alpha-trypsin inhibitor heavy chain H4 precursor; inter-alpha-trypsin inhibitor heavy chain H4; inter-alpha-trypsin inhibitor heavy chain family member 4", "tax_id": 9913, "disease": "", "pathway": " (bta:513700)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15213118;19674964;30573663", "class_list": "", "function": "Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 4, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006953 acute-phase response;GO:0030212 hyaluronan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3T052-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZBI7-1", "uniprot_id": [ { "id": "ATPMK_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3ZBI7", "type": "external" } ], "mass": 6435.0, "length": 58, "protein_name": "ATP synthase F(0) complex subunit k, mitochondrial", "gene_name": "ATP5MK", "organism": "Bovine", "refseq_name": "ATP synthase F(0) complex subunit k, mitochondrial", "refseq_ac": [ { "id": "NP_001106789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106789", "type": "external" } ], "gene_names_uniprotkb": "ATP5MK; ATPMD; DAPIT; USMG5", "gene_names_refseq": "AGP; ATP5MD; ATP5MK; DAPIT; USMG5", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit k, mitochondrial; ATP synthase membrane subunit DAPIT, mitochondrial; Diabetes-associated protein in insulin-sensitive tissues; Up-regulated during skeletal muscle growth protein 5", "protein_names_refseq": "ATP synthase F(0) complex subunit k, mitochondrial; ATP synthase membrane subunit DAPIT, mitochondrial; ATP synthase membrane subunit K, mitochondrial; diabetes-associated protein in insulin-sensitive tissues; diabetes-associated protein in insulin-sensitive tissue; up-regulated during skeletal muscle growth 5; up-regulated during skeletal muscle growth protein 5", "tax_id": 9913, "disease": "", "pathway": " (bta:101907000); (bta:767982); (R-BTA-163210); (R-BTA-8949613)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "17060615;17570365;17575325;25851905", "class_list": "", "function": "In the mitochondrial membrane, both AGP and MLQ proteins are almost quantitatively bound to ATP synthase.[MLQ], [RefSeq, PubMed]; Subunit k, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (By similarity). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:17570365, PubMed:25851905). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:17570365, PubMed:25851905). Required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3ZBI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8HXG6-1", "uniprot_id": [ { "id": "NDUAB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8HXG6", "type": "external" } ], "mass": 14758.0, "length": 141, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11", "gene_name": "NDUFA11", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11", "refseq_ac": [ { "id": "NP_783649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783649", "type": "external" } ], "gene_names_uniprotkb": "NDUFA11", "gene_names_refseq": "NDUFA11; b14.7", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; CI-B14.7; Complex I-B14.7; NADH-ubiquinone oxidoreductase subunit B14.7", "protein_names_refseq": "CI-B14.7; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; NADH-ubiquinone oxidoreductase subunit B14.7; complex I-B14.7; mitochondrial NADH:ubiquinone oxidoreductase B14.7", "tax_id": 9913, "disease": "", "pathway": " (bta:326346); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12381726;17060615", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZC19", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8HXG6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8HYY4-1", "uniprot_id": [ { "id": "UACA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8HYY4", "type": "external" } ], "mass": 161299.0, "length": 1401, "protein_name": "Uveal autoantigen with coiled-coil domains and ankyrin repeats protein", "gene_name": "UACA", "organism": "Bovine", "refseq_name": "uveal autoantigen with coiled-coil domains and ankyrin repeats protein", "refseq_ac": [ { "id": "NP_776634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776634", "type": "external" } ], "gene_names_uniprotkb": "UACA", "gene_names_refseq": "UACA", "protein_names_uniprotkb": "Uveal autoantigen with coiled-coil domains and ankyrin repeats protein; Beta-actin-binding protein; BetaCAP73", "protein_names_refseq": "beta-actin-binding protein; betaCAP73; uveal autoantigen with coiled-coil domains and ankyrin repeats protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281559)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11950601;14517325", "class_list": "", "function": "Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury (PubMed:11950601, PubMed:14517325). May be involved in multiple neurite formation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction;GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8HYY4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8WMV0-1", "uniprot_id": [ { "id": "GRK7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8WMV0", "type": "external" } ], "mass": 62125.0, "length": 552, "protein_name": "Rhodopsin kinase GRK7", "gene_name": "GRK7", "organism": "Bovine", "refseq_name": "rhodopsin kinase GRK7", "refseq_ac": [ { "id": "NP_776757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776757", "type": "external" } ], "gene_names_uniprotkb": "GRK7", "gene_names_refseq": "GPRK7; GRK7", "protein_names_uniprotkb": "Rhodopsin kinase GRK7; 2.7.11.14; G protein-coupled receptor kinase 7; G protein-coupled receptor kinase GRK7", "protein_names_refseq": "g protein-coupled receptor kinase GRK7; rhodopsin kinase GRK7", "tax_id": 9913, "disease": "", "pathway": " (bta:281802)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14561760", "class_list": "", "function": "Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.14", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0050254 rhodopsin kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8WMV0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8WMV1-1", "uniprot_id": [ { "id": "ERG24_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8WMV1", "type": "external" } ], "mass": 46751.0, "length": 418, "protein_name": "Delta(14)-sterol reductase TM7SF2", "gene_name": "TM7SF2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TM7SF2", "gene_names_refseq": "", "protein_names_uniprotkb": "Delta(14)-sterol reductase TM7SF2; 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; Delta-14-SR; Sterol C14-reductase; Transmembrane 7 superfamily member 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "11784322;16784888", "class_list": "", "function": "Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" } ], "go_molecular_function": "GO:0050661 NADP binding;GO:0050613 Delta14-sterol reductase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0006695 cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8WMV1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9BGI7-1", "uniprot_id": [ { "id": "OPSR_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9BGI7", "type": "external" } ], "mass": 40584.0, "length": 364, "protein_name": "Long-wave-sensitive opsin 1", "gene_name": "OPN1LW", "organism": "Bovine", "refseq_name": "long-wave-sensitive opsin 1", "refseq_ac": [ { "id": "NP_776991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776991", "type": "external" } ], "gene_names_uniprotkb": "OPN1LW; RCP", "gene_names_refseq": "OPN1LW; OPSN", "protein_names_uniprotkb": "Long-wave-sensitive opsin 1; Red cone photoreceptor pigment; Red-sensitive opsin", "protein_names_refseq": "long-wave-sensitive opsin 1; opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan); red cone photoreceptor pigment; red-sensitive opsin", "tax_id": 9913, "disease": "", "pathway": " (bta:282293); (R-BTA-2187335); (R-BTA-418594); (R-BTA-419771)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "15544351;18563085;18818650;19116670;19878048;24515108;25138898;30948514", "class_list": "", "function": "3.2 A crystal structure of the bovine Ops*-GalphaCT peptide complex, [RefSeq, PubMed]; A single dibasic degron motif is sufficient to initiate both the ER retention and subsequent degradation of ospin via an endoplasmic reticulum associated degradation pathway, [RefSeq, PubMed]; An extended network of hydrogen bonds connects the agonist retinal binding site to the G protein binding site via conserved amino acid residues. dynamics of the hydrogen-bonding network inside opsin couples to interactions at the G protein binding site, [RefSeq, PubMed]; G protein-coupled photoreceptor that selectively activates G(i) proteins in response to long-wavelength (red) light, thereby decreasing intracellular cAMP levels. Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade. Mediates visual perception of red light in cone photoreceptor cells., [UniProtKB, UniProtKB]; Instability of the retinitis pigmentosa P23H mutant opsin, [RefSeq, PubMed]; Ligand binding in opsin apparently follows an induced-fit three-point interaction model, with the ring, 9-methyl group, and aldehyde group as the determining selection elements., [RefSeq, PubMed]; Mammalian rod opsin biogenesis does not appear to have an absolute requirement for Cnx., [RefSeq, PubMed]; The crystal structure of ligand-free native opsin from bovine retinal rod cells at 2.9 angstrom (A) resolution, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9BGI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9TTY3-1", "uniprot_id": [ { "id": "SEC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9TTY3", "type": "external" } ], "mass": 41649.0, "length": 368, "protein_name": "Galactoside 2-alpha-L-fucosyltransferase SEC1", "gene_name": "SEC1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SEC1", "gene_names_refseq": "", "protein_names_uniprotkb": "Galactoside 2-alpha-L-fucosyltransferase SEC1; 2.4.1.-; Secretory blood group protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10814703;11606704", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of alpha 1,2-linked fucose to ganglioside GM1 and galacto-N-biose., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.344", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.344", "type": "external" }, { "id": "2.4.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.69", "type": "external" } ], "go_molecular_function": "GO:0031127 alpha-(1,2)-fucosyltransferase activity;GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 1540, "hit_score": 0.3, "record_id": "Q9TTY3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYS1-1", "uniprot_id": [ { "id": "RM13_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYS1", "type": "external" } ], "mass": 20575.0, "length": 178, "protein_name": "Large ribosomal subunit protein uL13m", "gene_name": "MRPL13", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein uL13m", "refseq_ac": [ { "id": "NP_001029977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029977", "type": "external" } ], "gene_names_uniprotkb": "MRPL13", "gene_names_refseq": "MRPL13", "protein_names_uniprotkb": "Large ribosomal subunit protein uL13m; 39S ribosomal protein L13, mitochondrial; L13mt; MRP-L13", "protein_names_refseq": "39S ribosomal protein L13, mitochondrial; L13mt; MRP-L13; large ribosomal subunit protein uL13m", "tax_id": 9913, "disease": "", "pathway": " (bta:617901); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11279069;16510155;20601428", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:0005761 mitochondrial ribosome;GO:0005739 mitochondrion", "go_biological_process": "GO:0006412 translation;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3SYS1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYU7-1", "uniprot_id": [ { "id": "TNPO1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYU7", "type": "external" } ], "mass": 102383.0, "length": 898, "protein_name": "Transportin-1", "gene_name": "TNPO1", "organism": "Bovine", "refseq_name": "transportin-1", "refseq_ac": [ { "id": "NP_001070008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070008", "type": "external" } ], "gene_names_uniprotkb": "TNPO1; KPNB2", "gene_names_refseq": "KPNB2; TNPO1; TRN", "protein_names_uniprotkb": "Transportin-1; Importin beta-2; Karyopherin beta-2", "protein_names_refseq": "importin beta-2; karyopherin (importin) beta 2; karyopherin beta-2; transportin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:767620); (R-BTA-450513)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. Mediates nuclear import of ADAR/ADAR1 in a RanGTP-dependent manner (By similarity). Main mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with the karyopherins KPNA1 and KPNA2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SYU7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBK2-1", "uniprot_id": [ { "id": "RM09_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBK2", "type": "external" } ], "mass": 30524.0, "length": 268, "protein_name": "Large ribosomal subunit protein bL9m", "gene_name": "MRPL9", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein bL9m", "refseq_ac": [ { "id": "NP_001030201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030201", "type": "external" } ], "gene_names_uniprotkb": "MRPL9", "gene_names_refseq": "MRPL9", "protein_names_uniprotkb": "Large ribosomal subunit protein bL9m; 39S ribosomal protein L9, mitochondrial; L9mt; MRP-L9", "protein_names_refseq": "39S ribosomal protein L9, mitochondrial; L9mt; MRP-L9; large ribosomal subunit protein bL9m", "tax_id": 9913, "disease": "", "pathway": " (bta:505981); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "11279069", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2TBK2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZBX6-1", "uniprot_id": [ { "id": "RM03_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3ZBX6", "type": "external" } ], "mass": 38600.0, "length": 348, "protein_name": "Large ribosomal subunit protein uL3m", "gene_name": "MRPL3", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein uL3m", "refseq_ac": [ { "id": "NP_001073786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073786", "type": "external" } ], "gene_names_uniprotkb": "MRPL3", "gene_names_refseq": "MRPL3", "protein_names_uniprotkb": "Large ribosomal subunit protein uL3m; 39S ribosomal protein L3, mitochondrial; L3mt; MRP-L3", "protein_names_refseq": "39S ribosomal protein L3, mitochondrial; L3mt; MRP-L3; large ribosomal subunit protein uL3m", "tax_id": 9913, "disease": "", "pathway": " (bta:614906); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279069;16510155", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3ZBX6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q148J6-1", "uniprot_id": [ { "id": "ARPC4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q148J6", "type": "external" } ], "mass": 19667.0, "length": 168, "protein_name": "Actin-related protein 2/3 complex subunit 4", "gene_name": "ARPC4", "organism": "Bovine", "refseq_name": "actin-related protein 2/3 complex subunit 4", "refseq_ac": [ { "id": "NP_001069631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069631", "type": "external" } ], "gene_names_uniprotkb": "ARPC4", "gene_names_refseq": "ARPC4", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 4; Arp2/3 complex 20 kDa subunit; p20-ARC", "protein_names_refseq": "actin related protein 2/3 complex, subunit 4, 20kDa; actin-related protein 2/3 complex subunit 4; arp2/3 complex 20 kDa subunit; p20-ARC", "tax_id": 9913, "disease": "", "pathway": " (bta:539459); (R-BTA-2029482); (R-BTA-3928662); (R-BTA-5663213); (R-BTA-8856828)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "11721045;15505213;23893131", "class_list": "", "function": "Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament., [UniProtKB, UniProtKB, UniProtKB]; The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0019899 enzyme binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0005885 Arp2/3 protein complex;GO:0042995 cell projection", "go_biological_process": "GO:0030041 actin filament polymerization;GO:0034314 Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q148J6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YDI5-1", "uniprot_id": [ { "id": "RM48_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2YDI5", "type": "external" } ], "mass": 24022.0, "length": 212, "protein_name": "Large ribosomal subunit protein mL48", "gene_name": "MRPL48", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein mL48 precursor", "refseq_ac": [ { "id": "NP_001040028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040028", "type": "external" } ], "gene_names_uniprotkb": "MRPL48", "gene_names_refseq": "MRPL48", "protein_names_uniprotkb": "Large ribosomal subunit protein mL48; 39S ribosomal protein L48, mitochondrial; L48mt; MRP-L48", "protein_names_refseq": "39S ribosomal protein L48, mitochondrial; L48mt; MRP-L48; large ribosomal subunit protein mL48 precursor; large ribosomal subunit protein mL48", "tax_id": 9913, "disease": "", "pathway": " (bta:615873); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11551941;20601428", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2YDI5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58CQ2-1", "uniprot_id": [ { "id": "ARC1B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q58CQ2", "type": "external" } ], "mass": 40976.0, "length": 372, "protein_name": "Actin-related protein 2/3 complex subunit 1B", "gene_name": "ARPC1B", "organism": "Bovine", "refseq_name": "actin-related protein 2/3 complex subunit 1B", "refseq_ac": [ { "id": "NP_001014844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014844", "type": "external" } ], "gene_names_uniprotkb": "ARPC1B", "gene_names_refseq": "ARPC1B", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 1B; Arp2/3 complex 41 kDa subunit; p41-ARC", "protein_names_refseq": "actin related protein 2/3 complex, subunit 1B, 41kDa; actin-related protein 2/3 complex subunit 1B; arp2/3 complex 41 kDa subunit; p41-ARC", "tax_id": 9913, "disease": "", "pathway": " (bta:326600); (R-BTA-2029482); (R-BTA-3928662); (R-BTA-5663213)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11721045;15505213;16305752;23893131", "class_list": "", "function": "Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8Q8;Q58DS1", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005885 Arp2/3 protein complex", "go_biological_process": "GO:0034314 Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q58CQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2NL27-1", "uniprot_id": [ { "id": "RT23_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2NL27", "type": "external" } ], "mass": 21594.0, "length": 190, "protein_name": "Small ribosomal subunit protein mS23", "gene_name": "MRPS23", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein mS23", "refseq_ac": [ { "id": "NP_001039657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039657", "type": "external" } ], "gene_names_uniprotkb": "MRPS23", "gene_names_refseq": "MRPS23", "protein_names_uniprotkb": "Small ribosomal subunit protein mS23; 28S ribosomal protein S23, mitochondrial; MRP-S23; S23mt", "protein_names_refseq": "28S ribosomal protein S23, mitochondrial; MRP-S23; S23mt; small ribosomal subunit protein mS23", "tax_id": 9913, "disease": "", "pathway": " (bta:515228)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10938081;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P82666", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2NL27-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YDF6-1", "uniprot_id": [ { "id": "RT35_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2YDF6", "type": "external" } ], "mass": 37070.0, "length": 325, "protein_name": "Small ribosomal subunit protein mS35", "gene_name": "MRPS35", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein mS35", "refseq_ac": [ { "id": "NP_001069087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069087", "type": "external" } ], "gene_names_uniprotkb": "MRPS35; MRPS28", "gene_names_refseq": "MRPS35", "protein_names_uniprotkb": "Small ribosomal subunit protein mS35; 28S ribosomal protein S28, mitochondrial; 28S ribosomal protein S35, mitochondrial; MRP-S28; MRP-S35; S28mt; S35mt", "protein_names_refseq": "28S ribosomal protein S28, mitochondrial; 28S ribosomal protein S35, mitochondrial; MRP-S28; MRP-S35; S28mt; S35mt; small ribosomal subunit protein mS35", "tax_id": 9913, "disease": "", "pathway": " (bta:513438); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11344316;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P82672", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2YDF6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHR7-1", "uniprot_id": [ { "id": "ARPC2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHR7", "type": "external" } ], "mass": 34349.0, "length": 300, "protein_name": "Actin-related protein 2/3 complex subunit 2", "gene_name": "ARPC2", "organism": "Bovine", "refseq_name": "actin-related protein 2/3 complex subunit 2", "refseq_ac": [ { "id": "NP_001029885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029885", "type": "external" } ], "gene_names_uniprotkb": "ARPC2", "gene_names_refseq": "ARPC2", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 2; Arp2/3 complex 34 kDa subunit; p34-ARC", "protein_names_refseq": "actin related protein 2/3 complex, subunit 2 (34 kD); actin related protein 2/3 complex, subunit 2, 34kDa; actin-related protein 2/3 complex subunit 2; arp2/3 complex 34 kDa subunit; p34-ARC", "tax_id": 9913, "disease": "", "pathway": " (bta:540838); (R-BTA-2029482); (R-BTA-3928662); (R-BTA-5663213); (R-BTA-8856828)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "11721045;15505213;23893131;29339159", "class_list": "", "function": "Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB]; Gmfg has two separate binding sites on Arp2/3 complex with high (site 1) and low (site 2) affinity. X-ray crystallography revealed closely located positions of Gmfg in site 1. Molecular dynamics simulation allowed determining the binding pocket for Gmfg in site 2., [RefSeq, PubMed]; The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0051015 actin filament binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0030041 actin filament polymerization;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0010592 positive regulation of lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3MHR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZ86-1", "uniprot_id": [ { "id": "RT26_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZ86", "type": "external" } ], "mass": 23774.0, "length": 205, "protein_name": "Small ribosomal subunit protein mS26", "gene_name": "MRPS26", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein mS26 precursor", "refseq_ac": [ { "id": "NP_001029686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029686", "type": "external" } ], "gene_names_uniprotkb": "MRPS26", "gene_names_refseq": "MRPS26", "protein_names_uniprotkb": "Small ribosomal subunit protein mS26; 28S ribosomal protein S26, mitochondrial; MRP-S26; S26mt", "protein_names_refseq": "28S ribosomal protein S26, mitochondrial; MRP-S26; S26mt; small ribosomal subunit protein mS26 precursor; small ribosomal subunit protein mS26", "tax_id": 9913, "disease": "", "pathway": " (bta:516004); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10751423;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3SZ86-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZE5-1", "uniprot_id": [ { "id": "MLRV_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZE5", "type": "external" } ], "mass": 18981.0, "length": 166, "protein_name": "Myosin regulatory light chain 2, ventricular/cardiac muscle isoform", "gene_name": "MYL2", "organism": "Bovine", "refseq_name": "myosin regulatory light chain 2, ventricular/cardiac muscle isoform", "refseq_ac": [ { "id": "NP_001030197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030197", "type": "external" } ], "gene_names_uniprotkb": "MYL2", "gene_names_refseq": "MLC-2s/v; MYL2", "protein_names_uniprotkb": "Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2s/v; MLC-2v; MLC-2; Myosin light chain 2, slow skeletal/ventricular muscle isoform", "protein_names_refseq": "MLC-2v; MLC-2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform; myosin, light chain 2, regulatory, cardiac, slow", "tax_id": 9913, "disease": "", "pathway": " (bta:505519)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "3979397", "class_list": "", "function": "Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030016 myofibril;GO:0031672 A band;GO:0016459 myosin complex", "go_biological_process": "GO:0007507 heart development;GO:0060047 heart contraction;GO:0060048 cardiac muscle contraction;GO:0002026 regulation of the force of heart contraction;GO:0042694 muscle cell fate specification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SZE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T0J3-1", "uniprot_id": [ { "id": "RM16_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T0J3", "type": "external" } ], "mass": 28573.0, "length": 251, "protein_name": "Large ribosomal subunit protein uL16m", "gene_name": "MRPL16", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein uL16m precursor", "refseq_ac": [ { "id": "NP_001029813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029813", "type": "external" } ], "gene_names_uniprotkb": "MRPL16", "gene_names_refseq": "MRPL16", "protein_names_uniprotkb": "Large ribosomal subunit protein uL16m; 39S ribosomal protein L16, mitochondrial; L16mt; MRP-L16", "protein_names_refseq": "39S ribosomal protein L16, mitochondrial; L16mt; MRP-L16; large ribosomal subunit protein uL16m precursor; large ribosomal subunit protein uL16m", "tax_id": 9913, "disease": "", "pathway": " (bta:538054); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279069;16510155", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3T0J3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ICW4-1", "uniprot_id": [ { "id": "GRB14_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5ICW4", "type": "external" } ], "mass": 61040.0, "length": 540, "protein_name": "Growth factor receptor-bound protein 14", "gene_name": "GRB14", "organism": "Bovine", "refseq_name": "growth factor receptor-bound protein 14", "refseq_ac": [ { "id": "NP_001011681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011681", "type": "external" } ], "gene_names_uniprotkb": "GRB14", "gene_names_refseq": "GRB14", "protein_names_uniprotkb": "Growth factor receptor-bound protein 14; GRB14 adapter protein", "protein_names_refseq": "GRB14 adapter protein; growth factor receptor-bound protein 14", "tax_id": 9913, "disease": "", "pathway": " (bta:497029)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15924411;16300394;23020213", "class_list": "", "function": "Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity)., [UniProtKB]; Grb14 contains a phosphorylated insulin receptor interacting domain between the pleckstrin homolog) and SH2 domains that binds to and forms a specific complex with the cytoplasmic domain of IRbeta, [RefSeq, PubMed]; The growth factor receptor bound protein (Grb) 14 NPXY motif could be acting as a dominant negative for insulin receptor substrate (IRS)-1 functions in the retina., [RefSeq, PubMed]; These findings suggest that Grb14 may play a regulatory role in granulosa cells during follicular deviation in cattle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5ICW4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76LU5-1", "uniprot_id": [ { "id": "IL21_BOVIN", "url": "https://www.uniprot.org/uniprot/Q76LU5", "type": "external" } ], "mass": 17690.0, "length": 152, "protein_name": "Interleukin-21", "gene_name": "IL21", "organism": "Bovine", "refseq_name": "interleukin-21 precursor", "refseq_ac": [ { "id": "NP_942129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942129", "type": "external" } ], "gene_names_uniprotkb": "IL21", "gene_names_refseq": "IL21", "protein_names_uniprotkb": "Interleukin-21; IL-21", "protein_names_refseq": "IL-21; interleukin-21 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:378475)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12969638;24555796;30573663", "class_list": "", "function": "Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006952 defense response;GO:0001819 positive regulation of cytokine production;GO:0002314 germinal center B cell differentiation;GO:0098586 cellular response to virus;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q76LU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNA3-1", "uniprot_id": [ { "id": "IMDH1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNA3", "type": "external" } ], "mass": 55424.0, "length": 514, "protein_name": "Inosine-5'-monophosphate dehydrogenase 1", "gene_name": "IMPDH1", "organism": "Bovine", "refseq_name": "inosine-5'-monophosphate dehydrogenase 1", "refseq_ac": [ { "id": "NP_001071309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071309", "type": "external" } ], "gene_names_uniprotkb": "IMPDH1; IMPDH", "gene_names_refseq": "IMPD 1; IMPDH 1; IMPDH1", "protein_names_uniprotkb": "Inosine-5'-monophosphate dehydrogenase 1; 1.1.1.205; IMP dehydrogenase 1; IMPD 1; IMPDH 1", "protein_names_refseq": "IMP (inosine monophosphate) dehydrogenase 1; IMP dehydrogenase 1; inosine-5'-monophosphate dehydrogenase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:504305); (R-BTA-6798695); (R-BTA-73817); (R-BTA-9748787)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "18974094;19393038", "class_list": "", "function": "Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "1.7.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.7", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0003938 IMP dehydrogenase activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006177 GMP biosynthetic process;GO:0006183 GTP biosynthetic process;GO:0097294 'de novo' XMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0JNA3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN76-1", "uniprot_id": [ { "id": "ZBT18_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JN76", "type": "external" } ], "mass": 58356.0, "length": 522, "protein_name": "Zinc finger and BTB domain-containing protein 18", "gene_name": "ZBTB18", "organism": "Bovine", "refseq_name": "zinc finger and BTB domain-containing protein 18", "refseq_ac": [ { "id": "NP_001071484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071484", "type": "external" } ], "gene_names_uniprotkb": "ZBTB18; ZNF238", "gene_names_refseq": "ZBTB18; ZNF238", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 18; Zinc finger protein 238", "protein_names_refseq": "zinc finger and BTB domain-containing protein 18; zinc finger protein 238", "tax_id": 9913, "disease": "", "pathway": " (bta:538793)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0000792 heterochromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JN76-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140T837-1", "uniprot_id": [ { "id": "A0A140T837_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A140T837", "type": "external" } ], "mass": 58437.0, "length": 520, "protein_name": "Amine oxidase", "gene_name": "MAOB", "organism": "Bovine", "refseq_name": "amine oxidase [flavin-containing] B", "refseq_ac": [ { "id": "NP_808813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808813", "type": "external" } ], "gene_names_uniprotkb": "MAOB", "gene_names_refseq": "MAOB", "protein_names_uniprotkb": "Amine oxidase; 1.4.3.-", "protein_names_refseq": "MAO-B; amine oxidase [flavin-containing] B; monoamine oxidase type B", "tax_id": 9913, "disease": "", "pathway": " (bta:338445); (R-BTA-141333)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "1.4.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.21", "type": "external" }, { "id": "1.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.4", "type": "external" } ], "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0042428 serotonin metabolic process;GO:0019607 phenylethylamine catabolic process;GO:0006576 biogenic amine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A140T837-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LXP4-1", "uniprot_id": [ { "id": "A0A3Q1LXP4_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LXP4", "type": "external" } ], "mass": 38245.0, "length": 345, "protein_name": "Beta-2-glycoprotein 1", "gene_name": "APOH", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "APOH", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-2-glycoprotein 1; Apolipoprotein H; Beta-2-glycoprotein I", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-114608)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0035473 lipase binding;GO:0060230 lipoprotein lipase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0007597 blood coagulation, intrinsic pathway;GO:0051918 negative regulation of fibrinolysis;GO:0001937 negative regulation of endothelial cell proliferation;GO:0016525 negative regulation of angiogenesis;GO:0010596 negative regulation of endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LXP4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140T893-1", "uniprot_id": [ { "id": "A0A140T893_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A140T893", "type": "external" } ], "mass": 78456.0, "length": 701, "protein_name": "Lutropin-choriogonadotropic hormone receptor", "gene_name": "LHCGR", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LHCGR", "gene_names_refseq": "", "protein_names_uniprotkb": "Lutropin-choriogonadotropic hormone receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-375281); (R-BTA-418555)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity;GO:0004964 luteinizing hormone receptor activity;GO:0035472 choriogonadotropin hormone receptor activity;GO:0038106 choriogonadotropin hormone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0050890 cognition;GO:0008584 male gonad development;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A140T893-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140T896-1", "uniprot_id": [ { "id": "A0A140T896_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A140T896", "type": "external" } ], "mass": 52969.0, "length": 484, "protein_name": "Serine hydroxymethyltransferase", "gene_name": "SHMT1", "organism": "Bovine", "refseq_name": "serine hydroxymethyltransferase, cytosolic isoform X1", "refseq_ac": [ { "id": "XP_024835644", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835644", "type": "external" } ], "gene_names_uniprotkb": "SHMT1", "gene_names_refseq": "SHMT1", "protein_names_uniprotkb": "Serine hydroxymethyltransferase; 2.1.2.1", "protein_names_refseq": "serine hydroxymethyltransferase, cytosolic isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-196757); (R-BTA-71262)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Interconversion of serine 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"missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004372 glycine hydroxymethyltransferase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005737 cytoplasm;GO:0070013 intracellular organelle lumen", "go_biological_process": "GO:0035999 tetrahydrofolate interconversion;GO:0046653 tetrahydrofolate metabolic process;GO:0019264 glycine biosynthetic process from serine;GO:0006417 regulation of translation;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A140T896-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140T898-1", "uniprot_id": [ { "id": "A0A140T898_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A140T898", "type": "external" } ], "mass": 25167.0, "length": 224, "protein_name": "Ras-related protein Rab-13", "gene_name": "RAB13", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RAB13", "gene_names_refseq": "", "protein_names_uniprotkb": "Ras-related protein Rab-13; 3.6.5.2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8873719); (R-BTA-8876198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0055038 recycling endosome membrane;GO:0008021 synaptic vesicle;GO:0030140 trans-Golgi network transport vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A140T898-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140T8C0-1", "uniprot_id": [ { "id": "A0A140T8C0_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A140T8C0", "type": "external" } ], "mass": 36241.0, "length": 322, "protein_name": "Interferon regulatory factor", "gene_name": "IRF1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IRF1", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon regulatory factor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:789216)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", 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"0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140T8C3-1", "uniprot_id": [ { "id": "A0A140T8C3_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A140T8C3", "type": "external" } ], "mass": 10442.0, "length": 92, "protein_name": "Selenoprotein K", "gene_name": "SELENOK", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SELENOK", "gene_names_refseq": "", "protein_names_uniprotkb": "Selenoprotein K", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006816 calcium ion transport;GO:0032755 positive regulation of interleukin-6 production;GO:0002230 positive regulation of defense response to virus by host;GO:0032760 positive regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A140T8C3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140T8C6-1", "uniprot_id": [ { "id": "A0A140T8C6_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A140T8C6", "type": "external" } ], "mass": 72456.0, "length": 660, "protein_name": "Prosaposin", "gene_name": "PSAP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PSAP", "gene_names_refseq": "", "protein_names_uniprotkb": "Prosaposin; Proactivator polypeptide", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-114608); (R-BTA-375276); (R-BTA-418594); (R-BTA-6798695); (R-BTA-9840310)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling., [UniProtKB, UniProtKB]; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling., [UniProtKB, UniProtKB, UniProtKB]; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1905573 ganglioside GM1 binding;GO:0002020 protease binding;GO:0005543 phospholipid binding;GO:0042803 protein homodimerization activity;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005764 lysosome;GO:0005770 late endosome;GO:0005576 extracellular region", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0006665 sphingolipid metabolic process;GO:0019216 regulation of lipid metabolic process;GO:0060736 prostate gland growth;GO:0060742 epithelial cell differentiation involved in prostate gland development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A140T8C6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LX22-1", "uniprot_id": [ { "id": "A0A3Q1LX22_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LX22", "type": "external" } ], "mass": 243070.0, "length": 2158, "protein_name": "Pericentriolar material 1", "gene_name": "PCM1", "organism": "Bovine", "refseq_name": "pericentriolar material 1 protein isoform X5", "refseq_ac": [ { "id": "XP_010818583", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010818583", "type": "external" } ], "gene_names_uniprotkb": "PCM1", "gene_names_refseq": "PCM1", "protein_names_uniprotkb": "Pericentriolar material 1", "protein_names_refseq": "pericentriolar material 1 protein isoform X5", "tax_id": 9913, "disease": "", "pathway": " (bta:525337); (R-BTA-2565942); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-8854518)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005737 cytoplasm;GO:0045177 apical part of cell;GO:0005814 centriole;GO:0034451 centriolar satellite", "go_biological_process": "GO:0060271 cilium assembly;GO:0071539 protein localization to centrosome;GO:0034454 microtubule anchoring at centrosome;GO:0090316 positive regulation of intracellular protein transport;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LX22-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LG25-1", "uniprot_id": [ { "id": "A0A3Q1LG25_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LG25", "type": "external" } ], "mass": 40104.0, "length": 365, "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase", "gene_name": "B3GAT3", "organism": "Bovine", "refseq_name": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 isoform X1", "refseq_ac": [ { "id": "XP_005226936", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226936", "type": "external" } ], "gene_names_uniprotkb": "B3GAT3", "gene_names_refseq": "B3GAT3", "protein_names_uniprotkb": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; 2.4.1.135", "protein_names_refseq": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1971475)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.135", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.135", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0090316 positive regulation of intracellular protein transport;GO:0005975 carbohydrate metabolic process;GO:0006024 glycosaminoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LG25-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LGY5-1", "uniprot_id": [ { "id": "A0A3Q1LGY5_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LGY5", "type": "external" } ], "mass": 65296.0, "length": 595, "protein_name": "Telomerase Cajal body protein 1", "gene_name": "WRAP53", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "WRAP53", "gene_names_refseq": "", "protein_names_uniprotkb": "Telomerase Cajal body protein 1; WD repeat-containing protein 79", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-171319); (R-BTA-174430)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0015030 Cajal body;GO:0005697 telomerase holoenzyme complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0090666 scaRNA localization to Cajal body;GO:0032203 telomere formation via telomerase;GO:0090671 telomerase RNA localization to Cajal body;GO:1904867 protein localization to Cajal body", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LGY5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LH17-1", "uniprot_id": [ { "id": "A0A3Q1LH17_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LH17", "type": "external" } ], "mass": 158909.0, "length": 1376, "protein_name": "Ribonuclease 3", "gene_name": "DROSHA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DROSHA", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribonuclease 3; 3.1.26.3; Ribonuclease III; protein Drosha", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0001530 lipopolysaccharide binding;GO:0017151 DEAD/H-box RNA helicase binding;GO:0070412 R-SMAD binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0014069 postsynaptic density", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0031054 pre-miRNA processing;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LH17-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D9H7-1", "uniprot_id": [ { "id": "UBP12_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D9H7", "type": "external" } ], "mass": 42683.0, "length": 369, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 12", "gene_name": "USP12", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 12", "refseq_ac": [ { "id": "NP_001091528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091528", "type": "external" } ], "gene_names_uniprotkb": "USP12", "gene_names_refseq": "USP12P1; USP12", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 12; 3.4.19.12; Deubiquitinating enzyme 12; Ubiquitin specific peptidase 12; Ubiquitin thioesterase 12; Ubiquitin-specific-processing protease 12", "protein_names_refseq": "deubiquitinating enzyme 12; ubiquitin carboxyl-terminal hydrolase 12; ubiquitin specific peptidase 12 pseudogene 1; ubiquitin thioesterase 12; ubiquitin thiolesterase 12; ubiquitin-specific protease 12-like 1; ubiquitin-specific-processing protease 12", "tax_id": 9913, "disease": "", "pathway": " (bta:525655); (R-BTA-5689880)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Deubiquitinating enzyme that plays various roles in the regulation of the immune response and inflammation. During TCR engagement and activation, translocates into the cytoplasm and deubiquitinates its substrates LAT and TRAT1 and prevents their lysosome-dependent degradation to stabilize the TCR signaling complex at the plasma membrane. Plays an essential role in the selective LPS-induced macrophage response through the activation of NF-kappa-B pathway. In addition, promotes that antiviral immune response through targeting DNA sensor IFI16 to inhibit its proteasome-dependent degradation. Participates in the interferon signaling pathway and antiviral response independently of its deubiquitinase activity by maintaining nuclear phosphorylated STAT1 levels via inhibition of its CREBBP-mediated acetylation and subsequent dephosphorylation (By similarity). Plays an intrinsic role in promoting the differentiation, activation and proliferation of CD4(+) T-cell by activating the NF-kappa-B signaling pathway through deubiquitinating and stabilizing B-cell lymphoma/leukemia 10/BCL10 (By similarity). In myeloid-derived suppressor cells promotes the activation of the NF-kappa-B via deubiquitination and stabilization of RELA (By similarity). Regulates the 'Lys-63'-linked polyubiquitin chains of BAX and thereby modulates the mitochondrial apoptotic process (By similarity). Negative regulator of NOTCH signaling that specifically deubiquitinates non-activated NOTCH receptors to target them for lysosomal degradation; deubiquitination of NOTCH stimulates its transport form late endosomes to lysosomes (By similarity). Protects neurons against HTT/huntingtin-induced polyglutamine expansion-dependent neurodegeneration through regulation of autophagic flux (By similarity). This function is independent of deubiquitinase activity or of other components of the USP12-WDR20-WDR48 deubiquitinating complex (By similarity). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5D9H7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1N178-1", "uniprot_id": [ { "id": "A0A3Q1N178_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1N178", "type": "external" } ], "mass": 62337.0, "length": 572, "protein_name": "Tripeptidyl-peptidase 1", "gene_name": "TPP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TPP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Tripeptidyl-peptidase 1; 3.4.14.9; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase I", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0008240 tripeptidyl-peptidase activity;GO:0004175 endopeptidase activity;GO:0035727 lysophosphatidic acid binding", "go_cellular_component": "GO:0005764 lysosome;GO:0005794 Golgi apparatus;GO:0045121 membrane raft;GO:0055037 recycling endosome", "go_biological_process": "GO:0006508 proteolysis;GO:0030855 epithelial cell differentiation;GO:0043171 peptide catabolic process;GO:0007417 central nervous system development;GO:0070198 protein localization to chromosome, telomeric region", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1N178-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNL7-1", "uniprot_id": [ { "id": "CX3C1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNL7", "type": "external" } ], "mass": 40849.0, "length": 358, "protein_name": "CX3C chemokine receptor 1", "gene_name": "CX3CR1", "organism": "Bovine", "refseq_name": "CX3C chemokine receptor 1", "refseq_ac": [ { "id": "NP_001096028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096028", "type": "external" } ], "gene_names_uniprotkb": "CX3CR1", "gene_names_refseq": "CX3CR1", "protein_names_uniprotkb": "CX3C chemokine receptor 1; C-X3-C CKR-1; CX3CR1; Fractalkine receptor", "protein_names_refseq": "CX3C chemokine receptor 1; chemokine (C-X3-C motif) receptor 1; fractalkine receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:100124525); (R-BTA-380108); (R-BTA-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. CX3CR1-CX3CL1 signaling mediates cell migratory functions. Responsible for the recruitment of natural killer (NK) cells to inflamed tissues. Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival. Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung. Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells. Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis. Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation. Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli. Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development. Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development. Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi. Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria. Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection (By similarity). Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031737 CX3C chemokine receptor binding;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0016495 C-X3-C chemokine receptor activity;GO:0019960 C-X3-C chemokine binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0090026 positive regulation of monocyte chemotaxis;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QNL7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV98-1", "uniprot_id": [ { "id": "EFMT3_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV98", "type": "external" } ], "mass": 24972.0, "length": 226, "protein_name": "EEF1A lysine methyltransferase 3", "gene_name": "EEF1AKMT3", "organism": "Bovine", "refseq_name": "EEF1A lysine methyltransferase 3", "refseq_ac": [ { "id": "NP_001096810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096810", "type": "external" } ], "gene_names_uniprotkb": "EEF1AKMT3; FAM119B; METTL21B", "gene_names_refseq": "EEF1AKMT3; FAM119B; METTL21B", "protein_names_uniprotkb": "EEF1A lysine methyltransferase 3; 2.1.1.-; Methyltransferase-like protein 21B; Protein-lysine methyltransferase METTL21B", "protein_names_refseq": "EEF1A lysine methyltransferase 3; family with sequence similarity 119, member B; methyltransferase like 21B; methyltransferase-like protein 21B; protein-lysine methyltransferase METTL21B", "tax_id": 9913, "disease": "", "pathway": " (bta:100125307)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein-lysine methyltransferase that selectively mono-, di- and trimethylates 'Lys-165' of the translation elongation factors EEF1A1 and EEF1A2 in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "3.4.24.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.71", "type": "external" } ], "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0008168 methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0018022 peptidyl-lysine methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV98-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LX43-1", "uniprot_id": [ { "id": "A0A3Q1LX43_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LX43", "type": "external" } ], "mass": 98232.0, "length": 914, "protein_name": "PAN2-PAN3 deadenylation complex subunit PAN3", "gene_name": "PAN3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PAN3", "gene_names_refseq": "", "protein_names_uniprotkb": "PAN2-PAN3 deadenylation complex subunit PAN3; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 3; Poly(A)-nuclease deadenylation complex subunit 3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-429947)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway. Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD). Its activity is required for efficient P-body formation. May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0031251 PAN complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LX43-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LL53-1", "uniprot_id": [ { "id": "A0A3Q1LL53_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LL53", "type": "external" } ], "mass": 41208.0, "length": 383, "protein_name": "CD34 molecule", "gene_name": "CD34", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CD34", "gene_names_refseq": "", "protein_names_uniprotkb": "CD34 molecule", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0043199 sulfate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0048471 perinuclear region of cytoplasm;GO:0009897 external side of plasma membrane;GO:0045171 intercellular bridge", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0007165 signal transduction;GO:0001894 tissue homeostasis;GO:0045766 positive regulation of angiogenesis;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LL53-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LM29-1", "uniprot_id": [ { "id": "A0A3Q1LM29_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LM29", "type": "external" } ], "mass": 116766.0, "length": 1050, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "TRIM24", "organism": "Bovine", "refseq_name": "transcription intermediary factor 1-alpha isoform X1", "refseq_ac": [ { "id": "XP_002687040", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687040", "type": "external" } ], "gene_names_uniprotkb": "TRIM24", "gene_names_refseq": "TRIM24", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "transcription intermediary factor 1-alpha isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:537246)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0004672 protein kinase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000791 euchromatin;GO:0031981 nuclear lumen", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0031647 regulation of protein stability;GO:0016567 protein ubiquitination;GO:0042981 regulation of apoptotic process;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LM29-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LMU4-1", "uniprot_id": [ { "id": "A0A3Q1LMU4_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LMU4", "type": "external" } ], "mass": 44988.0, "length": 408, "protein_name": "Inhibin beta B chain", "gene_name": "INHBB", "organism": "Bovine", "refseq_name": "inhibin beta B chain precursor", "refseq_ac": [ { "id": "NP_789822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789822", "type": "external" } ], "gene_names_uniprotkb": "INHBB", "gene_names_refseq": "INHBB", "protein_names_uniprotkb": "Inhibin beta B chain; Activin beta-B chain", "protein_names_refseq": "activin beta-B chain; betaB inhibin/activin; inhibin beta B chain precursor; inhibin beta B chain; inhibin beta B subunit; inhibin, beta B (activin AB beta polypeptide)", "tax_id": 9913, "disease": "", "pathway": " (bta:530430); (R-BTA-1502540); (R-BTA-209822); (R-BTA-2473224)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A. Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L., [UniProtKB, UniProtKB]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm;GO:0071944 cell periphery;GO:0005576 extracellular region", "go_biological_process": "GO:0046882 negative regulation of follicle-stimulating hormone secretion;GO:0060279 positive regulation of ovulation;GO:0032869 cellular response to insulin stimulus;GO:0009611 response to wounding;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LMU4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4J6-1", "uniprot_id": [ { "id": "ATP9B_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4J6", "type": "external" } ], "mass": 127457.0, "length": 1136, "protein_name": "Probable phospholipid-transporting ATPase IIB", "gene_name": "ATP9B", "organism": "Bovine", "refseq_name": "probable phospholipid-transporting ATPase IIB", "refseq_ac": [ { "id": "NP_001073724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073724", "type": "external" } ], "gene_names_uniprotkb": "ATP9B", "gene_names_refseq": "ATP9B", "protein_names_uniprotkb": "Probable phospholipid-transporting ATPase IIB; 7.6.2.1; ATPase class II type 9B", "protein_names_refseq": "ATPase class II type 9B; ATPase phospholipid transporting 9B (putative); probable phospholipid-transporting ATPase IIB", "tax_id": 9913, "disease": "", "pathway": " (bta:510301); (R-BTA-936837)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", 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"glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005802 trans-Golgi network;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006897 endocytosis;GO:0045332 phospholipid translocation;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4J6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LQH8-1", "uniprot_id": [ { "id": "A0A3Q1LQH8_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LQH8", "type": "external" } ], "mass": 77682.0, "length": 680, "protein_name": "Dihydroxyacetone phosphate acyltransferase", "gene_name": "GNPAT", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GNPAT", "gene_names_refseq": "", "protein_names_uniprotkb": "Dihydroxyacetone phosphate acyltransferase; 2.3.1.42; DAP-AT; DHAP-AT", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1483166); (R-BTA-75896); (R-BTA-9033241)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dihydroxyacetonephosphate acyltransferase catalyzing the first step in the biosynthesis of plasmalogens, a subset of phospholipids that differ from other glycerolipids by having an alkyl chain attached through a vinyl ether linkage at the sn-1 position of the glycerol backbone, and which unique physical properties have an impact on various aspects of cell signaling and membrane biology., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.26", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" } ], "go_molecular_function": "GO:0016287 glycerone-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0008611 ether lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LQH8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LQP6-1", "uniprot_id": [ { "id": "A0A3Q1LQP6_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LQP6", "type": "external" } ], "mass": 46626.0, "length": 430, "protein_name": "Pre-B-cell leukemia transcription factor 1", "gene_name": "PBX1", "organism": "Bovine", "refseq_name": "pre-B-cell leukemia transcription factor 1", "refseq_ac": [ { "id": "NP_001179697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179697", "type": "external" } ], "gene_names_uniprotkb": "PBX1", "gene_names_refseq": "PBX1", "protein_names_uniprotkb": "Pre-B-cell leukemia transcription factor 1; Homeobox protein PBX1", "protein_names_refseq": "pre-B-cell leukemia transcription factor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:540688)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0001222 transcription corepressor binding;GO:0140297 DNA-binding transcription factor binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LQP6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LQU8-1", "uniprot_id": [ { "id": "A0A3Q1LQU8_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LQU8", "type": "external" } ], "mass": 95733.0, "length": 863, "protein_name": "Semaphorin-4D", "gene_name": "SEMA4D", "organism": "Bovine", "refseq_name": "semaphorin-4D isoform X1", "refseq_ac": [ { "id": "XP_005210520", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210520", "type": "external" } ], "gene_names_uniprotkb": "SEMA4D", "gene_names_refseq": "SEMA4D", "protein_names_uniprotkb": "Semaphorin-4D", "protein_names_refseq": "semaphorin-4D isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-416550); (R-BTA-416572); (R-BTA-416700)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner. Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0002116 semaphorin receptor complex;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0061430 bone trabecula morphogenesis;GO:0070486 leukocyte aggregation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007162 negative regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LQU8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBH5-1", "uniprot_id": [ { "id": "ODAD3_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MBH5", "type": "external" } ], "mass": 72044.0, "length": 621, "protein_name": "Outer dynein arm-docking complex subunit 3", "gene_name": "ODAD3; RGL3", "organism": "Bovine", "refseq_name": "outer dynein arm-docking complex subunit 3", "refseq_ac": [ { "id": "NP_001095517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095517", "type": "external" } ], "gene_names_uniprotkb": "ODAD3; RGL3; CCDC151", "gene_names_refseq": "CCDC151; ODAD3", "protein_names_uniprotkb": "Outer dynein arm-docking complex subunit 3; Coiled-coil domain-containing protein 151", "protein_names_refseq": "coiled-coil domain containing 151; coiled-coil domain-containing protein 151; outer dynein arm-docking complex subunit 3", "tax_id": 9913, "disease": "", "pathway": " (bta:517994); (bta:785402); (R-BTA-5673001)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "34715025", "class_list": "", "function": "Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005929 cilium;GO:0035253 ciliary rootlet;GO:0005814 centriole;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:1902017 regulation of cilium assembly;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly;GO:0007264 small GTPase-mediated signal transduction;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7MBH5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LR40-1", "uniprot_id": [ { "id": "A0A3Q1LR40_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LR40", "type": "external" } ], "mass": 56307.0, "length": 500, "protein_name": "Endothelial lipase", "gene_name": "LIPG", "organism": "Bovine", "refseq_name": "endothelial lipase", "refseq_ac": [ { "id": "XP_002697812", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697812", "type": "external" } ], "gene_names_uniprotkb": "LIPG", "gene_names_refseq": "LIPG", "protein_names_uniprotkb": "Endothelial lipase; 3.1.1.32; 3.1.1.3; Phospholipase A1", "protein_names_refseq": "endothelial lipase", "tax_id": 9913, "disease": "", "pathway": " (bta:509808); (R-BTA-8964058)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exerts both phospholipase and triglyceride lipase activities. More active as a phospholipase than a triglyceride lipase. Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0008201 heparin binding;GO:0046872 metal ion binding;GO:0008970 phospholipase A1 activity;GO:0004465 lipoprotein lipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0005576 extracellular region", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0034375 high-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis;GO:0043691 reverse cholesterol transport;GO:0055091 phospholipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LR40-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB63-1", "uniprot_id": [ { "id": "CTNS_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB63", "type": "external" } ], "mass": 41828.0, "length": 367, "protein_name": "Cystinosin", "gene_name": "CTNS", "organism": "Bovine", "refseq_name": "cystinosin precursor", "refseq_ac": [ { "id": "NP_001095734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095734", "type": "external" } ], "gene_names_uniprotkb": "CTNS", "gene_names_refseq": "CTNS", "protein_names_uniprotkb": "Cystinosin", "protein_names_refseq": "cystinosin precursor; cystinosis, nephropathic", "tax_id": 9913, "disease": "", "pathway": " (bta:613527); (R-BTA-5223345); (R-BTA-9959399)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015295 solute:proton symporter activity;GO:0015184 L-cystine transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0042470 melanosome;GO:0033162 melanosome membrane;GO:0005770 late endosome", "go_biological_process": "GO:0048731 system development;GO:0015031 protein transport;GO:0050890 cognition;GO:0048513 animal organ development;GO:0042438 melanin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB63-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MLL6-1", "uniprot_id": [ { "id": "A0A3Q1MLL6_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MLL6", "type": "external" } ], "mass": 115022.0, "length": 1028, "protein_name": "Protein phosphatase 1 regulatory subunit", "gene_name": "PPP1R12A", "organism": "Bovine", "refseq_name": "protein phosphatase 1 regulatory subunit 12A", "refseq_ac": [ { "id": "NP_001421739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421739", "type": "external" } ], "gene_names_uniprotkb": "PPP1R12A", "gene_names_refseq": "PPP1R12A", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit", "protein_names_refseq": "protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019208 phosphatase regulator activity;GO:0004857 enzyme inhibitor activity;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001725 stress fiber;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030018 Z disc", "go_biological_process": "GO:0007165 signal transduction;GO:0000278 mitotic cell cycle;GO:0030155 regulation of cell adhesion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MLL6-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LRJ2-1", "uniprot_id": [ { "id": "TMM95_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LRJ2", "type": "external" } ], "mass": 19042.0, "length": 166, "protein_name": "Sperm-egg fusion protein TMEM95", "gene_name": "TMEM95", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TMEM95", "gene_names_refseq": "", "protein_names_uniprotkb": "Sperm-egg fusion protein TMEM95; Transmembrane protein 95", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "24391514;26385321;28859280;31315171", "class_list": "", "function": "Sperm protein required for fusion of sperm with the egg membrane during fertilization., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0N9GZ96", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0097524 sperm plasma membrane;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A3Q1LRJ2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLI6-1", "uniprot_id": [ { "id": "HEM1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLI6", "type": "external" } ], "mass": 71062.0, "length": 647, "protein_name": "5-aminolevulinate synthase, non-specific, mitochondrial", "gene_name": "ALAS1", "organism": "Bovine", "refseq_name": "5-aminolevulinate synthase, non-specific, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001094624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094624", "type": "external" } ], "gene_names_uniprotkb": "ALAS1", "gene_names_refseq": "ALAS-H; ALAS1", "protein_names_uniprotkb": "5-aminolevulinate synthase, non-specific, mitochondrial; 2.3.1.37; 5-aminolevulinic acid synthase 1; ALAS-H; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1", "protein_names_refseq": "5-aminolevulinate synthase, non-specific, mitochondrial precursor; 5-aminolevulinate synthase, non-specific, mitochondrial; 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; aminolevulinate, delta-, synthase 1; delta-ALA synthase 1; delta-ALA synthetase 1; delta-aminolevulinate synthase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:534286); (R-BTA-189451); (R-BTA-9837999)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0003870 5-aminolevulinate synthase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process;GO:0042541 hemoglobin biosynthetic process;GO:1903412 response to bile acid;GO:0006784 heme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLI6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H779-1", "uniprot_id": [ { "id": "FBXL2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H779", "type": "external" } ], "mass": 46975.0, "length": 423, "protein_name": "F-box/LRR-repeat protein 2", "gene_name": "FBXL2", "organism": "Bovine", "refseq_name": "F-box/LRR-repeat protein 2", "refseq_ac": [ { "id": "NP_001092623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092623", "type": "external" } ], "gene_names_uniprotkb": "FBXL2", "gene_names_refseq": "FBL2; FBXL2", "protein_names_uniprotkb": "F-box/LRR-repeat protein 2; F-box and leucine-rich repeat protein 2", "protein_names_refseq": "F-box/LRR-repeat protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:616212)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (By similarity). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant. The SCF(FBXL2) complex acts as a regulator of inflammation by mediating ubiquitination and degradation of TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5 and TRAF6) (By similarity). The SCF(FBXL2) complex acts as a negative regulator of the NLRP3 inflammasome by mediating ubiquitination and degradation of NLRP3 (By similarity). The GGTase-3 complex, composed of PTAR1 and RABGGTB, geranylgeranylates and targets FBXL2 to the cellular membranes, where FBXL2 forms part of the SCF(FBXL2) complex that mediates the degradation of membrane-anchored proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019903 protein phosphatase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0010506 regulation of autophagy;GO:0050727 regulation of inflammatory response;GO:0016567 protein ubiquitination;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H779-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MFA5-1", "uniprot_id": [ { "id": "A0A3Q1MFA5_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MFA5", "type": "external" } ], "mass": 45281.0, "length": 403, "protein_name": "Caspase-1", "gene_name": "CASP1", "organism": "Bovine", "refseq_name": "caspase-1 isoform X1", "refseq_ac": [ { "id": "XP_002692967", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692967", "type": "external" } ], "gene_names_uniprotkb": "CASP1", "gene_names_refseq": "CASP1", "protein_names_uniprotkb": "Caspase-1; 3.4.22.36; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45", "protein_names_refseq": "caspase-1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:514214); (R-BTA-448706); (R-BTA-5620971); (R-BTA-9008059); (R-BTA-9968551)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0032991 protein-containing complex;GO:0005576 extracellular region;GO:0097169 AIM2 inflammasome complex", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0006915 apoptotic process;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MFA5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1NEA4-1", "uniprot_id": [ { "id": "A0A3Q1NEA4_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1NEA4", "type": "external" } ], "mass": 88779.0, "length": 790, "protein_name": "Long-chain-fatty-acid--CoA ligase", "gene_name": "ACSL6", "organism": "Bovine", "refseq_name": "long-chain-fatty-acid--CoA ligase 6 isoform X1", "refseq_ac": [ { "id": "XP_059743971", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743971", "type": "external" } ], "gene_names_uniprotkb": "ACSL6", "gene_names_refseq": "ACSL6", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase; 6.2.1.15; 6.2.1.3; Acyl-CoA synthetase; Long-chain acyl-CoA synthetase", "protein_names_refseq": "long-chain-fatty-acid--CoA ligase 6 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0047676 arachidonate-CoA ligase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1NEA4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7E9-1", "uniprot_id": [ { "id": "NF2L1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7E9", "type": "external" } ], "mass": 83607.0, "length": 763, "protein_name": "Endoplasmic reticulum membrane sensor NFE2L1", "gene_name": "NFE2L1", "organism": "Bovine", "refseq_name": "endoplasmic reticulum membrane sensor NFE2L1", "refseq_ac": [ { "id": "NP_001095985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095985", "type": "external" } ], "gene_names_uniprotkb": "NFE2L1; NRF1", "gene_names_refseq": "NFE2L1; NRF1", "protein_names_uniprotkb": "Endoplasmic reticulum membrane sensor NFE2L1; NF-E2-related factor 1; NFE2-related factor 1; Nuclear factor erythroid 2-related factor 1; Nuclear factor, erythroid derived 2, like 1", "protein_names_refseq": "NF-E2-related factor 1; NFE2-related factor 1; endoplasmic reticulum membrane sensor NFE2L1; nuclear factor (erythroid-derived 2)-like 1; nuclear factor erythroid 2-related factor 1; nuclear factor, erythroid 2 like 1", "tax_id": 9913, "disease": "", "pathway": " (bta:534582)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "CNC-type bZIP family transcription factor that translocates to the nucleus and regulates expression of target genes in response to various stresses. Heterodimerizes with small-Maf proteins (MAFF, MAFG or MAFK) and binds DNA motifs including the antioxidant response elements (AREs), which regulate expression of genes involved in oxidative stress response. Activates or represses expression of target genes, depending on the context (By similarity). Plays a key role in cholesterol homeostasis by acting as a sensor of cholesterol excess: in low cholesterol conditions, translocates into the nucleus and represses expression of genes involved in defense against cholesterol excess, such as CD36 (By similarity). In excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity). Critical for redox balance in response to oxidative stress: acts by binding the AREs motifs on promoters and mediating activation of oxidative stress response genes, such as GCLC, GCLM, GSS, MT1 and MT2 (By similarity). Plays an essential role during fetal liver hematopoiesis: probably has a protective function against oxidative stress and is involved in lipid homeostasis in the liver (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, mediates the 'bounce-back' of proteasome subunits by translocating into the nucleus and activating expression of genes encoding proteasome subunits (By similarity). Also involved in regulating glucose flux (By similarity). Together with CEBPB; represses expression of DSPP during odontoblast differentiation. In response to ascorbic acid induction, activates expression of SP7/Osterix in osteoblasts (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7E9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LTK4-1", "uniprot_id": [ { "id": "A0A3Q1LTK4_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LTK4", "type": "external" } ], "mass": 223643.0, "length": 2016, "protein_name": "Disks large homolog 5", "gene_name": "DLG5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DLG5", "gene_names_refseq": "", "protein_names_uniprotkb": "Disks large homolog 5", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9013420); (R-BTA-9013424); (R-BTA-9696264); (R-BTA-9696270); (R-BTA-9696273)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008092 cytoskeletal protein binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0014069 postsynaptic density;GO:0036064 ciliary basal body", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0030336 negative regulation of cell migration;GO:0042130 negative regulation of T cell proliferation;GO:0051965 positive regulation of synapse assembly;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LTK4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1M249-1", "uniprot_id": [ { "id": "A0A3Q1M249_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1M249", "type": "external" } ], "mass": 97388.0, "length": 860, "protein_name": "Protein argonaute-3", "gene_name": "AGO3", "organism": "Bovine", "refseq_name": "protein argonaute-3", "refseq_ac": [ { "id": "NP_001001133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001133", "type": "external" } ], "gene_names_uniprotkb": "AGO3; EIF2C3", "gene_names_refseq": "AGO3; EIF2C3", "protein_names_uniprotkb": "Protein argonaute-3; Argonaute3; Eukaryotic translation initiation factor 2C 3; eIF-2C 3; eIF2C 3", "protein_names_refseq": "argonaute3; eIF-2C 3; eIF2C 3; eukaryotic translation initiation factor 2C, 3; protein argonaute-3", "tax_id": 9913, "disease": "", "pathway": " (bta:406231); (R-BTA-203927); (R-BTA-426486); (R-BTA-426496)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0035198 miRNA binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0010628 positive regulation of gene expression;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0006402 mRNA catabolic process;GO:0031054 pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1M249-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LU59-1", "uniprot_id": [ { "id": "A0A3Q1LU59_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LU59", "type": "external" } ], "mass": 67928.0, "length": 633, "protein_name": "Mitogen-activated protein kinase 15", "gene_name": "MAPK15", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MAPK15", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase 15; 2.7.11.24; Extracellular signal-regulated kinase 7; Extracellular signal-regulated kinase 8", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005911 cell-cell junction;GO:0005776 autophagosome;GO:0005814 centriole", "go_biological_process": "GO:1905832 positive regulation of spindle assembly;GO:0008284 positive regulation of cell population proliferation;GO:0010506 regulation of autophagy;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LU59-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LUB1-1", "uniprot_id": [ { "id": "A0A3Q1LUB1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LUB1", "type": "external" } ], "mass": 214552.0, "length": 1912, "protein_name": "Receptor-type tyrosine-protein phosphatase delta", "gene_name": "PTPRD", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTPRD", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase delta; 3.1.3.48", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-388844); (R-BTA-8849932)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0050839 cell adhesion molecule binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0042734 presynaptic membrane;GO:0098686 hippocampal mossy fiber to CA3 synapse;GO:0098685 Schaffer collateral - CA1 synapse;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030182 neuron differentiation;GO:0051965 positive regulation of synapse assembly;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LUB1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LUE0-1", "uniprot_id": [ { "id": "A0A3Q1LUE0_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LUE0", "type": "external" } ], "mass": 91662.0, "length": 822, "protein_name": "Fibroblast growth factor receptor", "gene_name": "FGFR1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FGFR1", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibroblast growth factor receptor; 2.7.10.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-109704); (R-BTA-1257604); (R-BTA-190370); (R-BTA-190373); (R-BTA-190374); (R-BTA-5654219); (R-BTA-5654687); (R-BTA-5654688); (R-BTA-5654689); (R-BTA-5654693); (R-BTA-5654726); (R-BTA-5673001); (R-BTA-6811558)", "pathway_count": 13, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" } ], "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0017134 fibroblast growth factor binding;GO:0008201 heparin binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0045597 positive regulation of cell differentiation;GO:0048513 animal organ development;GO:0048699 generation of neurons", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LUE0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9RY95-1", "uniprot_id": [ { "id": "A0AAA9RY95_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9RY95", "type": "external" } ], "mass": 60087.0, "length": 541, "protein_name": "Glucosylceramidase", "gene_name": "GBA1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GBA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Glucosylceramidase; 3.2.1.45", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9840310)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.45", "type": "external" }, { "id": "3.2.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.21", "type": "external" }, { "id": "3.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.46", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0004336 galactosylceramidase activity;GO:0005124 scavenger receptor binding;GO:0046527 glucosyltransferase activity;GO:0050295 steryl-beta-glucosidase activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005802 trans-Golgi network;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0006680 glucosylceramide catabolic process;GO:0008203 cholesterol metabolic process;GO:0046513 ceramide biosynthetic process;GO:0016241 regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9RY95-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LVZ0-1", "uniprot_id": [ { "id": "A0A3Q1LVZ0_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LVZ0", "type": "external" } ], "mass": 25324.0, "length": 223, "protein_name": "Adenylate kinase 4, mitochondrial", "gene_name": "AK4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AK4; AK3L1", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenylate kinase 4, mitochondrial; 2.7.4.10; 2.7.4.6; AK 4; Adenylate kinase 3-like; GTP:AMP phosphotransferase AK4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions. Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP. Phosphorylates only AMP when using GTP as phosphate donor. In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor. Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors. Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK. Plays a protective role in the cellular response to oxidative stress., [UniProtKB, UniProtKB]; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0046899 nucleoside triphosphate adenylate kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0046034 ATP metabolic process;GO:0046039 GTP metabolic process;GO:0009142 nucleoside triphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LVZ0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE08-1", "uniprot_id": [ { "id": "IMA5_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE08", "type": "external" } ], "mass": 60194.0, "length": 538, "protein_name": "Importin subunit alpha-5", "gene_name": "KPNA1", "organism": "Bovine", "refseq_name": "importin subunit alpha-5", "refseq_ac": [ { "id": "NP_001075202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075202", "type": "external" } ], "gene_names_uniprotkb": "KPNA1", "gene_names_refseq": "KPNA1", "protein_names_uniprotkb": "Importin subunit alpha-5; Karyopherin subunit alpha-1", "protein_names_refseq": "importin subunit alpha-1; importin subunit alpha-5; karyopherin alpha 1 (importin alpha 5)", "tax_id": 9913, "disease": "", "pathway": " (bta:539679); (R-BTA-140342); (R-BTA-68616); (R-BTA-909733)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "19420384;24257609;25019945;30053654", "class_list": "", "function": "Bovine ephemeral fever rhabdovirus alpha1 protein binds bovin importin beta1 and importin 7., [RefSeq, PubMed]; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA2 and Transportin-1/TNPO1 (By similarity)., [UniProtKB, UniProtKB]; Functions in nuclear protein import., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0045202 synapse;GO:0042564 NLS-dependent protein nuclear import complex", "go_biological_process": "GO:0006607 NLS-bearing protein import into nucleus;GO:0099527 postsynapse to nucleus signaling pathway;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2VE08-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MRJ9-1", "uniprot_id": [ { "id": "A0A3Q1MRJ9_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MRJ9", "type": "external" } ], "mass": 58077.0, "length": 539, "protein_name": "Nectin cell adhesion molecule 2", "gene_name": "NECTIN2", "organism": "Bovine", "refseq_name": "nectin-2 isoform X1", "refseq_ac": [ { "id": "XP_005219253", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219253", "type": "external" } ], "gene_names_uniprotkb": "NECTIN2", "gene_names_refseq": "NECTIN2; PVRL2; prr2", "protein_names_uniprotkb": "Nectin cell adhesion molecule 2", "protein_names_refseq": "nectin-2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-198933); (R-BTA-418990); (R-BTA-420597)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0042803 protein homodimerization activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0044291 cell-cell contact zone;GO:0043296 apical junction complex;GO:0005915 zonula adherens", "go_biological_process": "GO:0007155 cell adhesion;GO:0046596 regulation of viral entry into host cell;GO:0046814 coreceptor-mediated virion attachment to host cell;GO:0007286 spermatid development;GO:0050862 positive regulation of T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MRJ9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LZ02-1", "uniprot_id": [ { "id": "A0A3Q1LZ02_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LZ02", "type": "external" } ], "mass": 102368.0, "length": 917, "protein_name": "Hexokinase-2", "gene_name": "HK2", "organism": "Bovine", "refseq_name": "hexokinase-2", "refseq_ac": [ { "id": "XP_015328869", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328869", "type": "external" } ], "gene_names_uniprotkb": "HK2", "gene_names_refseq": "HK2", "protein_names_uniprotkb": "Hexokinase-2; 2.7.1.1; Hexokinase type II", "protein_names_refseq": "hexokinase-2", "tax_id": 9913, "disease": "", "pathway": " (bta:788926); (R-BTA-70171)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, 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angiogenesis;GO:2000378 negative regulation of reactive oxygen species metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0061621 canonical glycolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LZ02-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1M3Y2-1", "uniprot_id": [ { "id": "A0A3Q1M3Y2_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1M3Y2", "type": "external" } ], "mass": 233107.0, "length": 2060, "protein_name": "Chromodomain helicase DNA binding protein 3", "gene_name": "CHD3", "organism": "Bovine", "refseq_name": "chromodomain-helicase-DNA-binding protein 3 isoform X6", "refseq_ac": [ { "id": "XP_024836518", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836518", "type": "external" } ], "gene_names_uniprotkb": "CHD3", "gene_names_refseq": "CHD3", "protein_names_uniprotkb": "Chromodomain helicase DNA binding protein 3", "protein_names_refseq": "chromodomain-helicase-DNA-binding protein 3 isoform X6", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3214815); (R-BTA-6804758); (R-BTA-73762); (R-BTA-8943724); (R-BTA-9937850); (R-BTA-9940951)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016605 PML body", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007098 centrosome cycle;GO:0007051 spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1M3Y2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1M062-1", "uniprot_id": [ { "id": "A0A3Q1M062_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1M062", "type": "external" } ], "mass": 26420.0, "length": 256, "protein_name": "Mesoderm posterior bHLH transcription factor 1", "gene_name": "MESP1", "organism": "Bovine", "refseq_name": "mesoderm posterior protein 1", "refseq_ac": [ { "id": "XP_024838083", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838083", "type": "external" } ], "gene_names_uniprotkb": "MESP1", "gene_names_refseq": "MESP1", "protein_names_uniprotkb": "Mesoderm posterior bHLH transcription factor 1", "protein_names_refseq": "mesoderm posterior protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:112443239)", "pathway_count": 1, "publication_count": 0, 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"missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0060913 cardiac cell fate determination;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1M062-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1M0G8-1", "uniprot_id": [ { "id": "A0A3Q1M0G8_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1M0G8", "type": "external" } ], "mass": 58047.0, "length": 524, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "PAK2", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase PAK 2", "refseq_ac": [ { "id": "NP_001193656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193656", "type": "external" } ], "gene_names_uniprotkb": "PAK2", "gene_names_refseq": "PAK2", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "p21 protein (Cdc42/Rac)-activated kinase 2; serine/threonine-protein kinase PAK 2", "tax_id": 9913, "disease": "", "pathway": " (bta:513673); (R-BTA-202433); (R-BTA-2871796); (R-BTA-389359); (R-BTA-3928664); (R-BTA-399954); (R-BTA-4420097); 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The preferred substrate is L-aspartate. 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"https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1N4A7-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1M4X1-1", "uniprot_id": [ { "id": "A0A3Q1M4X1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1M4X1", "type": "external" } ], "mass": 122471.0, "length": 1125, "protein_name": "Angiomotin", "gene_name": "AMOT", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AMOT", "gene_names_refseq": "", "protein_names_uniprotkb": "Angiomotin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:535509); (R-BTA-2028269); (R-BTA-9762292)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043532 angiostatin binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030027 lamellipodium;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0035329 hippo signaling;GO:0030036 actin cytoskeleton organization;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1M4X1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7Z035-1", "uniprot_id": [ { "id": "EPN4_BOVIN", "url": "https://www.uniprot.org/uniprot/A7Z035", "type": "external" } ], "mass": 70522.0, "length": 643, "protein_name": "Clathrin interactor 1", "gene_name": "CLINT1", "organism": "Bovine", "refseq_name": "clathrin interactor 1", "refseq_ac": [ { "id": "NP_001098887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098887", "type": "external" } ], "gene_names_uniprotkb": "CLINT1; EPN4", "gene_names_refseq": "CLINT1", "protein_names_uniprotkb": "Clathrin interactor 1; Epsin-4", "protein_names_refseq": "clathrin interactor 1; epsin-4", "tax_id": 9913, "disease": "", "pathway": " (bta:538540)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0030276 clathrin binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005768 endosome;GO:0005798 Golgi-associated vesicle;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7Z035-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBJ4-1", "uniprot_id": [ { "id": "PTPRF_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MBJ4", "type": "external" } ], "mass": 211382.0, "length": 1898, "protein_name": "Receptor-type tyrosine-protein phosphatase F", "gene_name": "PTPRF", "organism": "Bovine", "refseq_name": "receptor-type tyrosine-protein phosphatase F precursor", "refseq_ac": [ { "id": "NP_001094549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094549", "type": "external" } ], "gene_names_uniprotkb": "PTPRF", "gene_names_refseq": "PTPRF", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase F; 3.1.3.48", "protein_names_refseq": "Receptor-type tyrosine-protein phosphatase F; receptor-type tyrosine-protein phosphatase F precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:512072); (R-BTA-388844); (R-BTA-77387); (R-BTA-8849932)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 6, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0008201 heparin binding;GO:0004725 protein tyrosine phosphatase activity;GO:0050839 cell adhesion molecule binding;GO:0044877 protein-containing complex binding;GO:0035373 chondroitin sulfate proteoglycan binding", "go_cellular_component": "GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0016477 cell migration;GO:1900121 negative regulation of receptor binding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBJ4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1M669-1", "uniprot_id": [ { "id": "A0A3Q1M669_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1M669", "type": "external" } ], "mass": 83282.0, "length": 786, "protein_name": "SIX homeobox 4", "gene_name": "SIX4", "organism": "Bovine", "refseq_name": "homeobox protein SIX4 isoform X1", "refseq_ac": [ { "id": "XP_024853845", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024853845", "type": "external" } ], "gene_names_uniprotkb": "SIX4", "gene_names_refseq": "SIX4", "protein_names_uniprotkb": "SIX homeobox 4", "protein_names_refseq": "homeobox protein SIX4 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:526104)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, 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"ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0050678 regulation of epithelial cell proliferation;GO:0061055 myotome development;GO:0061197 fungiform papilla morphogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1M669-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1M792-1", "uniprot_id": [ { "id": "A0A3Q1M792_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1M792", "type": "external" } ], "mass": 83018.0, "length": 739, "protein_name": "SUZ12 polycomb repressive complex 2 subunit", "gene_name": "SUZ12", "organism": "Bovine", "refseq_name": "polycomb protein SUZ12", "refseq_ac": [ { "id": "NP_001192516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192516", "type": "external" } ], "gene_names_uniprotkb": "SUZ12", "gene_names_refseq": "SUZ12", "protein_names_uniprotkb": "SUZ12 polycomb repressive complex 2 subunit", "protein_names_refseq": "polycomb protein SUZ12; suppressor of zeste 12 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:538774); (R-BTA-212300); (R-BTA-2559580); (R-BTA-3214841); (R-BTA-4551638); (R-BTA-8943724); (R-BTA-8953750); (R-BTA-9764725); (R-BTA-9909649)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:1990841 promoter-specific chromatin binding;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex;GO:0032993 protein-DNA complex;GO:0005677 chromatin silencing complex;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0140718 facultative heterochromatin formation;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1M792-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1M7Q3-1", "uniprot_id": [ { "id": "A0A3Q1M7Q3_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1M7Q3", "type": "external" } ], "mass": 85339.0, "length": 770, "protein_name": "GIT ArfGAP 1", "gene_name": "GIT1", "organism": "Bovine", "refseq_name": "ARF GTPase-activating protein GIT1 isoform X1", "refseq_ac": [ { "id": "XP_024836461", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836461", "type": "external" } ], "gene_names_uniprotkb": "GIT1", "gene_names_refseq": "GIT1", "protein_names_uniprotkb": "GIT ArfGAP 1", "protein_names_refseq": "ARF GTPase-activating protein GIT1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:515088); (R-BTA-3928664); (R-BTA-9013404); (R-BTA-9013406); (R-BTA-9013420); (R-BTA-9013423); (R-BTA-9013424)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0045202 synapse", "go_biological_process": "GO:0007626 locomotory behavior;GO:0032691 negative regulation of interleukin-1 beta production;GO:0071222 cellular response to lipopolysaccharide;GO:0007420 brain development;GO:0061743 motor learning", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1M7Q3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1M986-1", "uniprot_id": [ { "id": "A0A3Q1M986_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1M986", "type": "external" } ], "mass": 64629.0, "length": 570, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "GALNT2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GALNT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase; 2.4.1.-; Protein-UDP acetylgalactosaminyltransferase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6811436); (R-BTA-913709)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0051604 protein maturation;GO:0002639 positive regulation of immunoglobulin production", "synthesized_glycan_count": 7434, "hit_score": 0.1, "record_id": "A0A3Q1M986-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MA79-1", "uniprot_id": [ { "id": "A0A3Q1MA79_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MA79", "type": "external" } ], "mass": 399478.0, "length": 3686, "protein_name": "Laminin subunit alpha-5", "gene_name": "LAMA5", "organism": "Bovine", "refseq_name": "laminin subunit alpha-5", "refseq_ac": [ { "id": "XP_024856903", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856903", "type": "external" } ], "gene_names_uniprotkb": "LAMA5", "gene_names_refseq": "LAMA5", "protein_names_uniprotkb": "Laminin subunit alpha-5; Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha", "protein_names_refseq": "laminin subunit alpha-5", "tax_id": 9913, "disease": "", "pathway": " (bta:506751)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0048018 receptor ligand activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0031594 neuromuscular junction;GO:0043083 synaptic cleft;GO:0043259 laminin-10 complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0030155 regulation of cell adhesion;GO:0034446 substrate adhesion-dependent cell spreading;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MA79-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB80-1", "uniprot_id": [ { "id": "GTF2I_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB80", "type": "external" } ], "mass": 110125.0, "length": 978, "protein_name": "General transcription factor II-I", "gene_name": "GTF2I", "organism": "Bovine", "refseq_name": "general transcription factor II-I", "refseq_ac": [ { "id": "NP_001095647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095647", "type": "external" } ], "gene_names_uniprotkb": "GTF2I", "gene_names_refseq": "GTF2I; GTFII-I; TFII-I", "protein_names_uniprotkb": "General transcription factor II-I; GTFII-I; TFII-I", "protein_names_refseq": "general transcription factor II, i; general transcription factor II-I", "tax_id": 9913, "disease": "", "pathway": " (bta:534669)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB80-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MBB6-1", "uniprot_id": [ { "id": "A0A3Q1MBB6_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MBB6", "type": "external" } ], "mass": 67388.0, "length": 625, "protein_name": "Formimidoyltransferase-cyclodeaminase", "gene_name": "FTCD", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FTCD", "gene_names_refseq": "", "protein_names_uniprotkb": "Formimidoyltransferase-cyclodeaminase; 2.1.2.5; 4.3.1.4; Formiminotransferase-cyclodeaminase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-70921)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds and promotes bundling of vimentin filaments originating from the Golgi., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.5", "type": "external" }, { "id": "4.3.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.4", "type": "external" } ], "go_molecular_function": "GO:0008017 microtubule binding;GO:0005542 folic acid binding;GO:0030409 glutamate formimidoyltransferase activity;GO:0030412 formimidoyltetrahydrofolate cyclodeaminase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005814 centriole;GO:0030868 smooth endoplasmic reticulum membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0019557 L-histidine catabolic process to glutamate and formate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MBB6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4R1-1", "uniprot_id": [ { "id": "H2A2C_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4R1", "type": "external" } ], "mass": 13988.0, "length": 129, "protein_name": "Histone H2A type 2-C", "gene_name": "H2AC20; H2BC21", "organism": "Bovine", "refseq_name": "histone H2A type 2-C", "refseq_ac": [ { "id": "NP_001075189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075189", "type": "external" } ], "gene_names_uniprotkb": "H2AC20; H2BC21", "gene_names_refseq": "H2AC20; HIST2H2AC", "protein_names_uniprotkb": "Histone H2A type 2-C; H2A-clustered histone 20", "protein_names_refseq": "histone H2A type 2-C; histone cluster 2, H2ac", "tax_id": 9913, "disease": "", "pathway": " (bta:513666); (R-BTA-110330); (R-BTA-110331); (R-BTA-171306); (R-BTA-201722); (R-BTA-212300); (R-BTA-2299718); (R-BTA-2559580); (R-BTA-2559582); (R-BTA-2559586); (R-BTA-3214815); (R-BTA-3214847); (R-BTA-427359); (R-BTA-427413); (R-BTA-5250924); (R-BTA-5578749); (R-BTA-5625886); (R-BTA-5689880); (R-BTA-5693565); (R-BTA-5693571); (R-BTA-5693607); (R-BTA-606279); (R-BTA-68616); (R-BTA-69473); (R-BTA-73728); (R-BTA-73772); (R-BTA-8866654); (R-BTA-8936459); (R-BTA-9018519); (R-BTA-9670095); (R-BTA-9764725); (R-BTA-9841922); (R-BTA-9843940); (R-BTA-9843970); (R-BTA-9909649); (R-BTA-9940951); (R-BTA-9943411); (R-BTA-9943962); (R-BTA-9970672)", "pathway_count": 39, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome;GO:0005615 extracellular space", "go_biological_process": "GO:0031507 heterochromatin formation;GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4R1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MCG3-1", "uniprot_id": [ { "id": "A0A3Q1MCG3_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MCG3", "type": "external" } ], "mass": 63050.0, "length": 574, "protein_name": "5'-nucleotidase", "gene_name": "NT5E", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NT5E", "gene_names_refseq": "", "protein_names_uniprotkb": "5'-nucleotidase; 3.1.3.35; 3.1.3.5; 3.1.3.89; 3.1.3.91; 3.1.3.99; 5'-deoxynucleotidase; Ecto-5'-nucleotidase; IMP-specific 5'-nucleotidase; Thymidylate 5'-phosphatase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-196807); (R-BTA-73621); (R-BTA-74259)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.91", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91", "type": "external" }, { "id": "3.1.3.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89", "type": "external" }, { "id": "3.1.3.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99", "type": "external" }, { "id": "3.1.3.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.77", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0008253 5'-nucleotidase activity;GO:0002953 5'-deoxynucleotidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0046032 ADP catabolic process;GO:0006196 AMP catabolic process;GO:0007159 leukocyte cell-cell adhesion;GO:0031214 biomineral tissue development;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MCG3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IF62-1", "uniprot_id": [ { "id": "RPC1_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IF62", "type": "external" } ], "mass": 155791.0, "length": 1390, "protein_name": "DNA-directed RNA polymerase III subunit RPC1", "gene_name": "POLR3A", "organism": "Bovine", "refseq_name": "DNA-directed RNA polymerase III subunit RPC1", "refseq_ac": [ { "id": "NP_001077219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077219", "type": "external" } ], "gene_names_uniprotkb": "POLR3A", "gene_names_refseq": "POLR3A", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC1; 2.7.7.6; DNA-directed RNA polymerase III subunit A; RNA polymerase III subunit C1", "protein_names_refseq": "DNA-directed RNA polymerase III subunit A; DNA-directed RNA polymerase III subunit RPC1; RNA polymerase III subunit C1; polymerase (RNA) III (DNA directed) polypeptide A, 155kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:540308); (R-BTA-76061); (R-BTA-76066); (R-BTA-76071)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic core component of RNA polymerase III (Pol III), a DNA-dependent RNA polymerase which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Synthesizes 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (By similarity). Pol III-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol III is recruited to DNA promoters type I, II or III with the help of general transcription factors and other specific initiation factors. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity). Forms Pol III active center together with the second largest subunit POLR3B/RPC2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR3A/RPC1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR3B/RPC2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity)., [UniProtKB, UniProtKB]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0003899 DNA-directed RNA polymerase activity;GO:0000287 magnesium ion binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005666 RNA polymerase III complex;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0042797 tRNA transcription by RNA polymerase III;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0032728 positive regulation of interferon-beta production;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IF62-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QL88-1", "uniprot_id": [ { "id": "SAC1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QL88", "type": "external" } ], "mass": 67093.0, "length": 587, "protein_name": "Phosphatidylinositol-3-phosphatase SAC1", "gene_name": "SACM1L", "organism": "Bovine", "refseq_name": "phosphatidylinositol-3-phosphatase SAC1 isoform 1", "refseq_ac": [ { "id": "NP_001095601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095601", "type": "external" } ], "gene_names_uniprotkb": "SACM1L; SAC1", "gene_names_refseq": "SACM1L", "protein_names_uniprotkb": "Phosphatidylinositol-3-phosphatase SAC1; 3.1.3.64; Phosphatidylinositol-4-phosphate phosphatase; Suppressor of actin mutations 1-like protein", "protein_names_refseq": "SAC1 suppressor of actin mutations 1 like; phosphatidylinositide phosphatase SAC1; phosphatidylinositol-3-phosphatase SAC1 isoform 1; phosphatidylinositol-3-phosphatase SAC1; phosphatidylinositol-4-phosphate phosphatase; suppressor of actin mutations 1-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:530577); (R-BTA-1483248); (R-BTA-1660514)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (By similarity). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Dec 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046856 phosphatidylinositol dephosphorylation;GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QL88-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7H2-1", "uniprot_id": [ { "id": "STRN3_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7H2", "type": "external" } ], "mass": 87423.0, "length": 797, "protein_name": "Striatin-3", "gene_name": "STRN3", "organism": "Bovine", "refseq_name": "striatin-3", "refseq_ac": [ { "id": "NP_001091511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091511", "type": "external" } ], "gene_names_uniprotkb": "STRN3", "gene_names_refseq": "STRN3", "protein_names_uniprotkb": "Striatin-3", "protein_names_refseq": "striatin, calmodulin binding protein 3; striatin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:516375)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0035331 negative regulation of hippo signaling;GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7H2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MFH0-1", "uniprot_id": [ { "id": "A0A3Q1MFH0_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MFH0", "type": "external" } ], "mass": 63970.0, "length": 588, "protein_name": "Bone morphotic protein 6", "gene_name": "BMP6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "BMP6", "gene_names_refseq": "", "protein_names_uniprotkb": "Bone morphotic protein 6", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:617566)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MFH0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YY75-1", "uniprot_id": [ { "id": "SEH1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YY75", "type": "external" } ], "mass": 39641.0, "length": 360, "protein_name": "Nucleoporin SEH1", "gene_name": "SEH1L", "organism": "Bovine", "refseq_name": "nucleoporin SEH1", "refseq_ac": [ { "id": "NP_001096559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096559", "type": "external" } ], "gene_names_uniprotkb": "SEH1L", "gene_names_refseq": "SEH1L", "protein_names_uniprotkb": "Nucleoporin SEH1; GATOR2 complex protein SEH1; Nup107-160 subcomplex subunit SEH1", "protein_names_refseq": "GATOR complex protein SEH1; GATOR2 complex protein SEH1; SEH1-like; nucleoporin SEH1; nup107-160 subcomplex subunit SEH1", "tax_id": 9913, "disease": "", "pathway": " (bta:506509); (R-BTA-141430); (R-BTA-141444); (R-BTA-159227); (R-BTA-159230); (R-BTA-159231); (R-BTA-159236); (R-BTA-1855170); (R-BTA-1855196); (R-BTA-1855229); (R-BTA-191859); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-3108214); (R-BTA-3232142); (R-BTA-3301854); (R-BTA-3371453); (R-BTA-4085377); (R-BTA-4551638); (R-BTA-4570464); (R-BTA-4615885); (R-BTA-5663220); (R-BTA-9615933); (R-BTA-9639288); (R-BTA-9648025)", "pathway_count": 25, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005765 lysosomal membrane;GO:0000776 kinetochore;GO:0061700 GATOR2 complex;GO:0035859 Seh1-associated complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0006999 nuclear pore organization;GO:0015031 protein transport;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YY75-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MUG0-1", "uniprot_id": [ { "id": "A0A3Q1MUG0_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MUG0", "type": "external" } ], "mass": 76904.0, "length": 693, "protein_name": "Broad substrate specificity ATP-binding cassette transporter ABCG2", "gene_name": "ABCG2", "organism": "Bovine", "refseq_name": "broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1", "refseq_ac": [ { "id": "XP_024849079", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849079", "type": "external" } ], "gene_names_uniprotkb": "ABCG2", "gene_names_refseq": "ABCG2", "protein_names_uniprotkb": "Broad substrate specificity ATP-binding cassette transporter ABCG2; 7.6.2.2; ATP-binding cassette sub-family G member 2; Urate exporter", "protein_names_refseq": "broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity;GO:0042803 protein homodimerization activity;GO:0015562 efflux transmembrane transporter activity", "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0016324 apical plasma membrane;GO:0045121 membrane raft;GO:0031526 brush border membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0046415 urate metabolic process;GO:0070633 transepithelial transport;GO:1990962 xenobiotic transport across blood-brain barrier;GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MUG0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MVF2-1", "uniprot_id": [ { "id": "A0A3Q1MVF2_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MVF2", "type": "external" } ], "mass": 81052.0, "length": 722, "protein_name": "Transporter", "gene_name": "SLC6A6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC6A6", "gene_names_refseq": "", "protein_names_uniprotkb": "Transporter", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-352230)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005369 taurine:sodium symporter activity;GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0022858 alanine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042995 cell projection;GO:0098982 GABA-ergic synapse;GO:0016323 basolateral plasma membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0006836 neurotransmitter transport;GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0015734 taurine transmembrane transport;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MVF2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKH1-1", "uniprot_id": [ { "id": "EFHC1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKH1", "type": "external" } ], "mass": 74032.0, "length": 640, "protein_name": "EF-hand domain-containing protein 1", "gene_name": "EFHC1", "organism": "Bovine", "refseq_name": "EF-hand domain-containing protein 1", "refseq_ac": [ { "id": "NP_001179173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179173", "type": "external" } ], "gene_names_uniprotkb": "EFHC1", "gene_names_refseq": "EFHC1", "protein_names_uniprotkb": "EF-hand domain-containing protein 1; Myoclonin-1", "protein_names_refseq": "EF-hand domain-containing protein 1; myoclonin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:510124)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19393038;34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:34715025, PubMed:37327785). Microtubule-associated protein which regulates cell division and neuronal migration during cortical development (By similarity). Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (By similarity). May enhance calcium influx through CACNA1E and stimulate programmed cell death (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0072686 mitotic spindle", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0021795 cerebral cortex cell migration;GO:0000281 mitotic cytokinesis;GO:0007052 mitotic spindle organization;GO:0060285 cilium-dependent cell motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E1BKH1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MIB0-1", "uniprot_id": [ { "id": "A0A3Q1MIB0_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MIB0", "type": "external" } ], "mass": 189224.0, "length": 1657, "protein_name": "Ras GTPase-activating-like protein IQGAP1", "gene_name": "IQGAP1", "organism": "Bovine", "refseq_name": "ras GTPase-activating-like protein IQGAP1", "refseq_ac": [ { "id": "XP_024838093", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838093", "type": "external" } ], "gene_names_uniprotkb": "IQGAP1", "gene_names_refseq": "IQGAP1", "protein_names_uniprotkb": "Ras GTPase-activating-like protein IQGAP1", "protein_names_refseq": "ras GTPase-activating-like protein IQGAP1", "tax_id": 9913, "disease": "", "pathway": " (bta:104968536); (R-BTA-373753); (R-BTA-5626467); (R-BTA-5674135); (R-BTA-6798695); (R-BTA-8980692); (R-BTA-9013106); (R-BTA-9013404); (R-BTA-9013406); (R-BTA-9013420); (R-BTA-9013424)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane. Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005874 microtubule;GO:0005911 cell-cell junction;GO:0005925 focal adhesion;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0043410 positive regulation of MAPK cascade;GO:0071277 cellular response to calcium ion;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MIB0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QF96-1", "uniprot_id": [ { "id": "UT1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5QF96", "type": "external" } ], "mass": 41473.0, "length": 384, "protein_name": "Urea transporter 1", "gene_name": "SLC14A1", "organism": "Bovine", "refseq_name": "urea transporter 1", "refseq_ac": [ { "id": "NP_001008666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008666", "type": "external" } ], "gene_names_uniprotkb": "SLC14A1; UT-B", "gene_names_refseq": "RACH1; SLC14A1; UT-1; UT-B", "protein_names_uniprotkb": "Urea transporter 1; Solute carrier family 14 member 1; UT-B; Urea transporter B; Urea transporter, erythrocyte", "protein_names_refseq": "solute carrier family 14 member 1 (Kidd blood group); urea transporter 1; urea transporter B; urea transporter, erythrocyte", "tax_id": 9913, "disease": "", "pathway": " (bta:493988); (R-BTA-549127)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15845882;22733730;24812069", "class_list": "", "function": "Bovine UT-B is expressed in bovine rumen and may function to transport urea into rumen as part of ruminant urea nitrogen salvaging process., [RefSeq, PubMed]; Data suggest that expression of UT-B (urea transporter B) in rumen mucosa can be modulated by dietary factors; here, UT-B and AQP3 (aquaglyceroporin-3) expression are upregulated with solid food intake (low-protein diet of plant forage) at weaning., [RefSeq, PubMed]; Mediates the transport of urea driven by a concentration gradient across the cell membrane (PubMed:15845882, PubMed:22733730). Mediates the transport of urea across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; The rate of urea conduction in UT-B is increased by hypoosmotic stress, and the site of osmoregulation coincides with the location of the energy barrier, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2KJI0;Q2TM53", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005372 water transmembrane transporter activity;GO:0015265 urea channel activity;GO:0015204 urea transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0071918 urea transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5QF96-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MKW9-1", "uniprot_id": [ { "id": "A0A3Q1MKW9_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MKW9", "type": "external" } ], "mass": 176208.0, "length": 1621, "protein_name": "Tyrosine-protein kinase receptor", "gene_name": "ALK", "organism": "Bovine", "refseq_name": "ALK tyrosine kinase receptor isoform X2", "refseq_ac": [ { "id": "XP_024855246", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855246", "type": "external" } ], "gene_names_uniprotkb": "ALK", "gene_names_refseq": "ALK", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor; 2.7.10.1", "protein_names_refseq": "ALK tyrosine kinase receptor isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:536642); (R-BTA-201556); (R-BTA-9851151)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0030298 receptor signaling protein tyrosine kinase activator activity;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0042127 regulation of cell population proliferation;GO:0050995 negative regulation of lipid catabolic process;GO:0097009 energy homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MKW9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1YQ93-1", "uniprot_id": [ { "id": "ODAM_BOVIN", "url": "https://www.uniprot.org/uniprot/A1YQ93", "type": "external" } ], "mass": 31163.0, "length": 277, "protein_name": "Odontogenic ameloblast-associated protein", "gene_name": "ODAM", "organism": "Bovine", "refseq_name": "odontogenic ameloblast-associated protein precursor", "refseq_ac": [ { "id": "NP_001073784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073784", "type": "external" } ], "gene_names_uniprotkb": "ODAM; APIN", "gene_names_refseq": "ODAM", "protein_names_uniprotkb": "Odontogenic ameloblast-associated protein; Apin", "protein_names_refseq": "APin; odontogenic ameloblast-associated protein precursor; odontogenic ameloblast-associated protein; odontogenic, ameloblast asssociated", "tax_id": 9913, "disease": "", "pathway": " (bta:613976)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression;GO:0032956 regulation of actin cytoskeleton organization;GO:0042475 odontogenesis of dentin-containing tooth;GO:0031214 biomineral tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1YQ93-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MN22-1", "uniprot_id": [ { "id": "A0A3Q1MN22_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MN22", "type": "external" } ], "mass": 58950.0, "length": 560, "protein_name": "SRY-box transcription factor 9", "gene_name": "SOX9", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SOX9", "gene_names_refseq": "", "protein_names_uniprotkb": "SRY-box transcription factor 9", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3769402); (R-BTA-8878166)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MN22-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MPR3-1", "uniprot_id": [ { "id": "A0A3Q1MPR3_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MPR3", "type": "external" } ], "mass": 147709.0, "length": 1331, "protein_name": "Contactin associated protein 2", "gene_name": "CNTNAP2", "organism": "Bovine", "refseq_name": "contactin-associated protein-like 2", "refseq_ac": [ { "id": "XP_024846981", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846981", "type": "external" } ], "gene_names_uniprotkb": "CNTNAP2", "gene_names_refseq": "CNTNAP2", "protein_names_uniprotkb": "Contactin associated protein 2", "protein_names_refseq": "contactin-associated protein-like 2", "tax_id": 9913, "disease": "", "pathway": " (bta:100337375)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0016020 membrane;GO:0030673 axolemma", "go_biological_process": "GO:0007155 cell adhesion;GO:0008283 cell population proliferation;GO:0030534 adult behavior;GO:0035176 social behavior;GO:1903598 positive regulation of gap junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MPR3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QR16-1", "uniprot_id": [ { "id": "RNPS1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QR16", "type": "external" } ], "mass": 34196.0, "length": 305, "protein_name": "RNA-binding protein with serine-rich domain 1", "gene_name": "RNPS1", "organism": "Bovine", "refseq_name": "RNA-binding protein with serine-rich domain 1", "refseq_ac": [ { "id": "NP_001095311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095311", "type": "external" } ], "gene_names_uniprotkb": "RNPS1", "gene_names_refseq": "RNPS1", "protein_names_uniprotkb": "RNA-binding protein with serine-rich domain 1", "protein_names_refseq": "RNA binding protein S1, serine-rich domain; RNA-binding protein with serine-rich domain 1", "tax_id": 9913, "disease": "", "pathway": " (bta:504506); (R-BTA-159236); (R-BTA-72163); (R-BTA-975957)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 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"url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008093 cytoskeletal anchor activity;GO:0050321 tau-protein kinase activity;GO:0106310 protein serine kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030425 dendrite;GO:0005930 axoneme;GO:0005856 cytoskeleton", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0051301 cell division;GO:0000226 microtubule cytoskeleton organization;GO:0030030 cell projection organization;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MUZ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1MXU7-1", "uniprot_id": [ { "id": "A0A3Q1MXU7_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1MXU7", "type": "external" } ], "mass": 274391.0, "length": 2363, "protein_name": "Spectrin beta chain", "gene_name": "SPTBN1", "organism": "Bovine", "refseq_name": "spectrin beta chain, non-erythrocytic 1", "refseq_ac": [ { "id": "NP_001179205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179205", "type": "external" } ], "gene_names_uniprotkb": "SPTBN1", "gene_names_refseq": "SPTBN1", "protein_names_uniprotkb": "Spectrin beta chain", "protein_names_refseq": "spectrin beta chain, non-erythrocytic 1", "tax_id": 9913, "disease": "", "pathway": " (bta:526027)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005543 phospholipid binding;GO:0051020 GTPase binding;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0030673 axolemma;GO:0031430 M band", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0030036 actin cytoskeleton organization;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0000281 mitotic cytokinesis;GO:0043001 Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1MXU7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QP79-1", "uniprot_id": [ { "id": "COL12_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QP79", "type": "external" } ], "mass": 81751.0, "length": 742, "protein_name": "Collectin-12", "gene_name": "COLEC12", "organism": "Bovine", "refseq_name": "collectin-12", "refseq_ac": [ { "id": "NP_001095313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095313", "type": "external" } ], "gene_names_uniprotkb": "COLEC12; CLP1", "gene_names_refseq": "COLEC12", "protein_names_uniprotkb": "Collectin-12; CL-P1; Collectin placenta protein 1", "protein_names_refseq": "CL-P1; collectin placenta protein 1; collectin sub-family member 12; collectin-12", "tax_id": 9913, "disease": "", "pathway": " (bta:504741); (R-BTA-198933); (R-BTA-3000480)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Also binds to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR) (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0030169 low-density lipoprotein particle binding;GO:0038187 pattern recognition receptor activity;GO:0005044 scavenger receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006955 immune response;GO:0030198 extracellular matrix organization;GO:0006910 phagocytosis, recognition;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QP79-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1N3H9-1", "uniprot_id": [ { "id": "A0A3Q1N3H9_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1N3H9", "type": "external" } ], "mass": 128706.0, "length": 1145, "protein_name": "Rho GTPase-activating protein 7", "gene_name": "DLC1", "organism": "Bovine", "refseq_name": "rho GTPase-activating protein 7 isoform X2", "refseq_ac": [ { "id": "XP_024842008", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842008", "type": "external" } ], "gene_names_uniprotkb": "DLC1", "gene_names_refseq": "DLC-1; DLC1; StARD12", "protein_names_uniprotkb": "Rho GTPase-activating protein 7; Deleted in liver cancer 1 protein homolog; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StAR-related lipid transfer protein 12", "protein_names_refseq": "rho GTPase-activating protein 7 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8980692); (R-BTA-9013106); (R-BTA-9013148); (R-BTA-9013406)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008289 lipid binding;GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0005901 caveola;GO:0032587 ruffle membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0030336 negative regulation of cell migration;GO:0051895 negative regulation of focal adhesion assembly;GO:0035024 negative regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1N3H9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1N402-1", "uniprot_id": [ { "id": "A0A3Q1N402_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1N402", "type": "external" } ], "mass": 68128.0, "length": 602, "protein_name": "Baculoviral IAP repeat containing 2", "gene_name": "BIRC2", "organism": "Bovine", "refseq_name": "baculoviral IAP repeat-containing protein 2 isoform X2", "refseq_ac": [ { "id": "XP_024831473", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831473", "type": "external" } ], "gene_names_uniprotkb": "BIRC2", "gene_names_refseq": "BIRC2", "protein_names_uniprotkb": "Baculoviral IAP repeat containing 2", "protein_names_refseq": "baculoviral IAP repeat-containing protein 2 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:539314); (R-BTA-111465); (R-BTA-168638); (R-BTA-5357786); (R-BTA-5357905); (R-BTA-5357956); (R-BTA-5668541); (R-BTA-5675482); (R-BTA-5676594); (R-BTA-5689880); (R-BTA-937041)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061630 ubiquitin protein ligase activity;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0031398 positive regulation of protein ubiquitination;GO:0042981 regulation of apoptotic process;GO:0033209 tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1N402-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H742-1", "uniprot_id": [ { "id": "PLSI_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H742", "type": "external" } ], "mass": 70532.0, "length": 630, "protein_name": "Plastin-1", "gene_name": "PLS1", "organism": "Bovine", "refseq_name": "plastin-1", "refseq_ac": [ { "id": "NP_001096769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096769", "type": "external" } ], "gene_names_uniprotkb": "PLS1", "gene_names_refseq": "PLS1; Plastin-1", "protein_names_uniprotkb": "Plastin-1", "protein_names_refseq": "plastin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:616560)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, 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"0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1N707-1", "uniprot_id": [ { "id": "A0A3Q1N707_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1N707", "type": "external" } ], "mass": 132455.0, "length": 1219, "protein_name": "Serine/threonine-protein kinase WNK4", "gene_name": "WNK4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "WNK4", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase WNK4; 2.7.11.1; Protein kinase lysine-deficient 4; Protein kinase with no lysine 4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031404 chloride ion binding;GO:0008200 ion channel inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005923 bicellular tight junction;GO:0044297 cell body;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030644 intracellular chloride ion homeostasis;GO:0006954 inflammatory response;GO:0008217 regulation of blood pressure;GO:0071466 cellular response to xenobiotic stimulus;GO:0035932 aldosterone secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1N707-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1N7P8-1", "uniprot_id": [ { "id": "A0A3Q1N7P8_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1N7P8", "type": "external" } ], "mass": 308067.0, "length": 2701, "protein_name": "Inositol 1,4,5-trisphosphate receptor", "gene_name": "ITPR2", "organism": "Bovine", "refseq_name": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform X2", "refseq_ac": [ { "id": "XP_024847122", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847122", "type": "external" } ], "gene_names_uniprotkb": "ITPR2", "gene_names_refseq": "ITPR2; insP3R2", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate receptor", "protein_names_refseq": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-114508); (R-BTA-139853); (R-BTA-381676); (R-BTA-5578775); (R-BTA-983695)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity;GO:0005524 ATP binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0043235 receptor complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0001666 response to hypoxia;GO:0051209 release of sequestered calcium ion into cytosol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1N7P8-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7H5-1", "uniprot_id": [ { "id": "CASC3_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7H5", "type": "external" } ], "mass": 76147.0, "length": 703, "protein_name": "Protein CASC3", "gene_name": "CASC3", "organism": "Bovine", "refseq_name": "protein CASC3", "refseq_ac": [ { "id": "NP_001091538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091538", "type": "external" } ], "gene_names_uniprotkb": "CASC3; MLN51", "gene_names_refseq": "Btz; CASC3", "protein_names_uniprotkb": "Protein CASC3; Btz; Cancer susceptibility candidate gene 3 protein; MLN 51 homolog; Metastatic lymph node gene 51 protein homolog; Protein barentsz", "protein_names_refseq": "MLN 51 homolog; cancer susceptibility 3; cancer susceptibility candidate 3; cancer susceptibility candidate gene 3 protein; metastatic lymph node 51; metastatic lymph node gene 51 protein homolog; protein CASC3; protein barentsz", "tax_id": 9913, "disease": "", "pathway": " (bta:531673); (R-BTA-159236); (R-BTA-72163); (R-BTA-975957)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0030425 dendrite;GO:0031965 nuclear membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000398 mRNA splicing, via spliceosome;GO:0051028 mRNA transport;GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7H5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YWC4-1", "uniprot_id": [ { "id": "ATAD3_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YWC4", "type": "external" } ], "mass": 66107.0, "length": 586, "protein_name": "ATPase family AAA domain-containing protein 3", "gene_name": "ATAD3A; ATAD3", "organism": "Bovine", "refseq_name": "ATPase family AAA domain-containing protein 3", "refseq_ac": [ { "id": "NP_001098932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098932", "type": "external" } ], "gene_names_uniprotkb": "ATAD3A; ATAD3", "gene_names_refseq": "ATAD3A; ATAD3B; ATAD3", "protein_names_uniprotkb": "ATPase family AAA domain-containing protein 3", "protein_names_refseq": "ATPase family AAA domain-containing protein 3; ATPase family, AAA domain containing 3B; ATPase family, AAA domain containing 3", "tax_id": 9913, "disease": "", "pathway": " (bta:784353); (R-BTA-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20154147;29286187;41018975", "class_list": "", "function": "ATAD3A positively regulated milk protein, fat, and lactose biosynthesis, and cell proliferation by mammary epithelial cells., [RefSeq, PubMed]; Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity. Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006974 DNA damage response;GO:0001558 regulation of cell growth;GO:0007005 mitochondrion organization;GO:1903898 negative regulation of PERK-mediated unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A7YWC4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3S5ZPF0-1", "uniprot_id": [ { "id": "A0A3S5ZPF0_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3S5ZPF0", "type": "external" } ], "mass": 101809.0, "length": 916, "protein_name": "hexokinase", "gene_name": "HK1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HK1", "gene_names_refseq": "", "protein_names_uniprotkb": "hexokinase; 2.7.1.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-446205); (R-BTA-70171)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0005524 ATP binding;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0045121 membrane raft", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process;GO:0051156 glucose 6-phosphate metabolic process;GO:0019318 hexose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3S5ZPF0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KN27-1", "uniprot_id": [ { "id": "K2C74_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KN27", "type": "external" } ], "mass": 59952.0, "length": 550, "protein_name": "Keratin, type II cytoskeletal 74", "gene_name": "KRT74", "organism": "Bovine", "refseq_name": "keratin, type II cytoskeletal 74", "refseq_ac": [ { "id": "NP_001076916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076916", "type": "external" } ], "gene_names_uniprotkb": "KRT74", "gene_names_refseq": "KRT74", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 74; CK-74; Cytokeratin-74; K74; Keratin-74; Type II inner root sheath-specific keratin-K6irs4; Type-II keratin Kb37", "protein_names_refseq": "CK-74; K74; cytokeratin-74; keratin, type II cytoskeletal 74; type II inner root sheath-specific keratin-K6irs4; type-II keratin Kb37", "tax_id": 9913, "disease": "", "pathway": " (bta:525034); (R-BTA-6805567); (R-BTA-6809371)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990254 keratin filament binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization;GO:0031069 hair follicle morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KN27-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBD1-1", "uniprot_id": [ { "id": "MPIP1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MBD1", "type": "external" } ], "mass": 59142.0, "length": 525, "protein_name": "M-phase inducer phosphatase 1", "gene_name": "CDC25A", "organism": "Bovine", "refseq_name": "M-phase inducer phosphatase 1", "refseq_ac": [ { "id": "NP_001094570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094570", "type": "external" } ], "gene_names_uniprotkb": "CDC25A", "gene_names_refseq": "CDC25A", "protein_names_uniprotkb": "M-phase inducer phosphatase 1; 3.1.3.48; Dual specificity phosphatase Cdc25A", "protein_names_refseq": "Dual specificity phosphatase Cdc25A; M-phase inducer phosphatase 1; cell division cycle 25 homolog A", "tax_id": 9913, "disease": "", "pathway": " (bta:520188); (R-BTA-5689880); (R-BTA-69200); (R-BTA-69202); (R-BTA-69273); (R-BTA-69601); (R-BTA-69656)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin-E, in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0009314 response to radiation;GO:0110032 positive regulation of G2/MI transition of meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBD1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58DD0-1", "uniprot_id": [ { "id": "ACE2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q58DD0", "type": "external" } ], "mass": 93067.0, "length": 804, "protein_name": "Angiotensin-converting enzyme 2", "gene_name": "ACE2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ACE2", "gene_names_refseq": "", "protein_names_uniprotkb": "Angiotensin-converting enzyme 2; 3.4.17.-; 3.4.17.23; ACE-related carboxypeptidase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2022377)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.17.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.23", "type": "external" }, { "id": "3.4.17.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.-", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0008241 peptidyl-dipeptidase activity;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0009986 cell surface", "go_biological_process": "GO:0002003 angiotensin maturation;GO:0006508 proteolysis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0050727 regulation of inflammatory response;GO:0003051 angiotensin-mediated drinking behavior", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q58DD0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A493UA87-1", "uniprot_id": [ { "id": "A0A493UA87_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A493UA87", "type": "external" } ], "mass": 36050.0, "length": 316, "protein_name": "Aldo-keto reductase family 1 member B1", "gene_name": "AKR1B1", "organism": "Bovine", "refseq_name": "aldo-keto reductase family 1 member B1", "refseq_ac": [ { "id": "NP_001012537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012537", "type": "external" } ], "gene_names_uniprotkb": "AKR1B1", "gene_names_refseq": "AKR1B1", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member B1; 1.1.1.21; 1.1.1.300; 1.1.1.372; 1.1.1.54; Aldehyde reductase; Aldose reductase", "protein_names_refseq": "20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; AR; aldehyde reductase; aldo-keto reductase family 1 member B1; aldose reductase", "tax_id": 9913, "disease": "", "pathway": " (bta:317748); (R-BTA-196108); (R-BTA-5652227)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12551929;23747692;25528584", "class_list": "", "function": "Is most likely the enzyme responsible for the production of prostaglandin f2 alpha in the bovine endometrium, [RefSeq, PubMed]; L-idose is the best alternative to D-glucose in studies on aldose reductase., [RefSeq, PubMed]; Prostaglandin F synthase activity of human and bovine aldo-keto reductases, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.357", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.188", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.188", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" }, { "id": "1.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.19", "type": "external" }, { "id": "1.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.20", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" } ], "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0047655 allyl-alcohol dehydrogenase activity;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0043795 glyceraldehyde oxidoreductase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006060 sorbitol metabolic process;GO:0044597 daunorubicin metabolic process;GO:0044598 doxorubicin metabolic process;GO:0046370 fructose biosynthetic process;GO:0071475 cellular hyperosmotic salinity response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A493UA87-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8K3KFT3-1", "uniprot_id": [ { "id": "A0A8K3KFT3_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A8K3KFT3", "type": "external" } ], "mass": 37300.0, "length": 338, "protein_name": "11-beta-hydroxysteroid dehydrogenase 1", "gene_name": "HSD11B1", "organism": "Bovine", "refseq_name": "11-beta-hydroxysteroid dehydrogenase 1 isoform X1", "refseq_ac": [ { "id": "XP_010811843", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811843", "type": "external" } ], "gene_names_uniprotkb": "HSD11B1", "gene_names_refseq": "11-DH; 11HSD1; HSD11B1", "protein_names_uniprotkb": "11-beta-hydroxysteroid dehydrogenase 1; 1.1.1.146; 1.1.1.201; 7-oxosteroid reductase; Corticosteroid 11-beta-dehydrogenase isozyme 1", "protein_names_refseq": "11-beta-hydroxysteroid dehydrogenase 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-194002); (R-BTA-9757110)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.146", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.146", "type": "external" }, { "id": "1.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.201", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0042803 protein homodimerization activity;GO:0005496 steroid binding;GO:0050661 NADP binding;GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006713 glucocorticoid catabolic process;GO:0006706 steroid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8K3KFT3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFD7-1", "uniprot_id": [ { "id": "ZNT7_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFD7", "type": "external" } ], "mass": 41745.0, "length": 376, "protein_name": "Zinc transporter 7", "gene_name": "SLC30A7", "organism": "Bovine", "refseq_name": "zinc transporter 7", "refseq_ac": [ { "id": "NP_001077229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077229", "type": "external" } ], "gene_names_uniprotkb": "SLC30A7", "gene_names_refseq": "SLC30A7", "protein_names_uniprotkb": "Zinc transporter 7; Solute carrier family 30 member 7", "protein_names_refseq": "zinc transporter 7; znT-7", "tax_id": 9913, "disease": "", "pathway": " (bta:613851)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a zinc transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006882 intracellular zinc ion homeostasis;GO:1904257 zinc ion import into Golgi lumen", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFD7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDT6-1", "uniprot_id": [ { "id": "ZDH21_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDT6", "type": "external" } ], "mass": 31463.0, "length": 265, "protein_name": "Palmitoyltransferase ZDHHC21", "gene_name": "ZDHHC21", "organism": "Bovine", "refseq_name": "palmitoyltransferase ZDHHC21", "refseq_ac": [ { "id": "NP_001075003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075003", "type": "external" } ], "gene_names_uniprotkb": "ZDHHC21", "gene_names_refseq": "ZDHHC21", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC21; 2.3.1.225; Zinc finger DHHC domain-containing protein 21", "protein_names_refseq": "DHHC-21; palmitoyltransferase ZDHHC21; probable palmitoyltransferase ZDHHC21; zinc finger DHHC domain-containing protein 21; zinc finger DHHC-type containing 21", "tax_id": 9913, "disease": "", "pathway": " (bta:535814); (R-BTA-203615); (R-BTA-9009391)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity). Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Also has a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1903140 regulation of establishment of endothelial barrier;GO:0003056 regulation of vascular associated smooth muscle contraction;GO:0006612 protein targeting to membrane;GO:0071875 adrenergic receptor signaling pathway;GO:0018230 peptidyl-L-cysteine S-palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDT6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9RYG5-1", "uniprot_id": [ { "id": "A0AAA9RYG5_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9RYG5", "type": "external" } ], "mass": 102706.0, "length": 945, "protein_name": "Amine oxidase", "gene_name": "MAOA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MAOA", "gene_names_refseq": "", "protein_names_uniprotkb": "Amine oxidase; 1.4.3.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "1.4.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.21", "type": "external" }, { "id": "1.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.4", "type": "external" } ], "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0006584 catecholamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9RYG5-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YY55-1", "uniprot_id": [ { "id": "HACD3_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YY55", "type": "external" } ], "mass": 43133.0, "length": 362, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3", "gene_name": "HACD3", "organism": "Bovine", "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3", "refseq_ac": [ { "id": "NP_001096786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096786", "type": "external" } ], "gene_names_uniprotkb": "HACD3; PTPLAD1", "gene_names_refseq": "HACD3; PTPLAD1", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3; 3-hydroxyacyl-CoA dehydratase 3; 4.2.1.134; HACD3; Protein-tyrosine phosphatase-like A domain-containing protein 1", "protein_names_refseq": "protein tyrosine phosphatase-like A domain containing 1; protein tyrosine phosphatase-like protein PTPLAD1; protein-tyrosine phosphatase-like A domain-containing protein 1; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3", "tax_id": 9913, "disease": "", "pathway": " (bta:100125237); (R-BTA-75876)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.134", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0007264 small GTPase-mediated signal transduction;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YY55-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDW9-1", "uniprot_id": [ { "id": "IKZF3_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDW9", "type": "external" } ], "mass": 58154.0, "length": 509, "protein_name": "Zinc finger protein Aiolos", "gene_name": "IKZF3", "organism": "Bovine", "refseq_name": "zinc finger protein Aiolos", "refseq_ac": [ { "id": "NP_001075082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075082", "type": "external" } ], "gene_names_uniprotkb": "IKZF3; ZNFN1A3", "gene_names_refseq": "IKZF3", "protein_names_uniprotkb": "Zinc finger protein Aiolos; Ikaros family zinc finger protein 3", "protein_names_refseq": "IKAROS family zinc finger 3 (Aiolos); ikaros family zinc finger protein 3; zinc finger protein Aiolos", "tax_id": 9913, "disease": "", "pathway": " (bta:540676); (R-BTA-9940951)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030183 B cell differentiation;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDW9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK16-1", "uniprot_id": [ { "id": "CCNF_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK16", "type": "external" } ], "mass": 87898.0, "length": 788, "protein_name": "Cyclin-F", "gene_name": "CCNF", "organism": "Bovine", "refseq_name": "cyclin-F", "refseq_ac": [ { "id": "NP_001092340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092340", "type": "external" } ], "gene_names_uniprotkb": "CCNF", "gene_names_refseq": "CCNF", "protein_names_uniprotkb": "Cyclin-F", "protein_names_refseq": "cyclin-F", "tax_id": 9913, "disease": "", "pathway": " (bta:505200)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (By similarity). Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (By similarity). Mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (By similarity). In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (By similarity). Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (By similarity). May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0010997 anaphase-promoting complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005815 microtubule organizing center;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0000082 G1/S transition of mitotic cell cycle;GO:0051726 regulation of cell cycle;GO:0010826 negative regulation of centrosome duplication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PK16-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLK2-1", "uniprot_id": [ { "id": "SOSB1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLK2", "type": "external" } ], "mass": 22275.0, "length": 211, "protein_name": "SOSS complex subunit B1", "gene_name": "NABP2", "organism": "Bovine", "refseq_name": "SOSS complex subunit B1", "refseq_ac": [ { "id": "NP_001094621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094621", "type": "external" } ], "gene_names_uniprotkb": "NABP2; OBFC2B; SSB1", "gene_names_refseq": "NABP2; OBFC2B", "protein_names_uniprotkb": "SOSS complex subunit B1; Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; SOSS-B1; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; Single-stranded DNA-binding protein 1", "protein_names_refseq": "SOSS complex subunit B1; SOSS-B1; oligonucleotide/oligosaccharide-binding fold containing 2B; oligonucleotide/oligosaccharide-binding fold-containing protein 2B; sensor of single-strand DNA complex subunit B1; sensor of ssDNA subunit B1; single-stranded DNA-binding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:533842); (R-BTA-6807505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003697 single-stranded DNA binding;GO:0098505 G-rich strand telomeric DNA binding;GO:0070182 DNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0070876 SOSS complex;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination;GO:0044818 mitotic G2/M transition checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLK2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7J5-1", "uniprot_id": [ { "id": "RHOU_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7J5", "type": "external" } ], "mass": 27824.0, "length": 255, "protein_name": "Rho-related GTP-binding protein RhoU", "gene_name": "RHOU", "organism": "Bovine", "refseq_name": "rho-related GTP-binding protein RhoU", "refseq_ac": [ { "id": "NP_001091616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091616", "type": "external" } ], "gene_names_uniprotkb": "RHOU", "gene_names_refseq": "RHOU", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoU; 3.6.5.2", "protein_names_refseq": "ras homolog gene family, member U; rho-related GTP-binding protein RhoU", "tax_id": 9913, "disease": "", "pathway": " (bta:781044); (R-BTA-9013420)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds to and activates protein kinase PAK1. Plays a role in the regulation of cell morphology, cytoskeletal organization and focal adhesion assembly during cell migration. Also stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0002102 podosome", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7J5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9U0M1-1", "uniprot_id": [ { "id": "A0AAA9U0M1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9U0M1", "type": "external" } ], "mass": 38309.0, "length": 341, "protein_name": "Solute carrier family 25 member 30", "gene_name": "SLC25A30", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC25A30", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 25 member 30", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9U0M1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNK3-1", "uniprot_id": [ { "id": "HTRA2_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNK3", "type": "external" } ], "mass": 49163.0, "length": 458, "protein_name": "Serine protease HTRA2, mitochondrial", "gene_name": "HTRA2", "organism": "Bovine", "refseq_name": "serine protease HTRA2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001071424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071424", "type": "external" } ], "gene_names_uniprotkb": "HTRA2", "gene_names_refseq": "HTRA2", "protein_names_uniprotkb": "Serine protease HTRA2, mitochondrial; 3.4.21.108", "protein_names_refseq": "Omi stress-regulated endoprotease; high temperature requirement protein A2; serine protease HTRA2, mitochondrial precursor; serine protease HTRA2, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:523039); (R-BTA-9837999)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (By similarity). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (By similarity). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (By similarity). Cleaves THAP5 and promotes its degradation during apoptosis (By similarity)., [UniProtKB, UniProtKB]; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.108", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.108", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0031966 mitochondrial membrane;GO:0032991 protein-containing complex;GO:0005634 nucleus", "go_biological_process": "GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:1903146 regulation of autophagy of mitochondrion;GO:0034599 cellular response to oxidative stress;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNK3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN69-1", "uniprot_id": [ { "id": "MARH3_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JN69", "type": "external" } ], "mass": 28505.0, "length": 253, "protein_name": "E3 ubiquitin-protein ligase MARCHF3", "gene_name": "MARCHF3", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase MARCHF3", "refseq_ac": [ { "id": "NP_001071409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071409", "type": "external" } ], "gene_names_uniprotkb": "MARCHF3; MARCH3", "gene_names_refseq": "MARCH3; MARCHF3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF3; 2.3.2.27; MARCH-III; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; RING-type E3 ubiquitin transferase MARCHF3", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH3; E3 ubiquitin-protein ligase MARCHF3; MARCH-III; RING-type E3 ubiquitin transferase MARCH3; RING-type E3 ubiquitin transferase MARCHF3; membrane-associated RING finger protein 3; membrane-associated RING-CH protein III; membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase", "tax_id": 9913, "disease": "", "pathway": " (bta:520348)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome;GO:0031901 early endosome membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JN69-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9S9X2-1", "uniprot_id": [ { "id": "A0AAA9S9X2_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9S9X2", "type": "external" } ], "mass": 56045.0, "length": 486, "protein_name": "Phosphatidylserine synthase", "gene_name": "PTDSS2", "organism": "Bovine", "refseq_name": "phosphatidylserine synthase 2 isoform X1", "refseq_ac": [ { "id": "XP_024843412", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843412", "type": "external" } ], "gene_names_uniprotkb": "PTDSS2", "gene_names_refseq": "PTDSS2", "protein_names_uniprotkb": "Phosphatidylserine synthase; 2.7.8.29; Serine-exchange enzyme", "protein_names_refseq": "phosphatidylserine synthase 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:100336649)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.29", "type": "external" } ], "go_molecular_function": "GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity;GO:0106245 L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006659 phosphatidylserine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9S9X2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9SAV7-1", "uniprot_id": [ { "id": "A0AAA9SAV7_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9SAV7", "type": "external" } ], "mass": 42402.0, "length": 395, "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase", "gene_name": "AGPAT2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AGPAT2", "gene_names_refseq": "", "protein_names_uniprotkb": "1-acyl-sn-glycerol-3-phosphate acyltransferase; 2.3.1.51", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1483166); (R-BTA-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0001819 positive regulation of cytokine production;GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9SAV7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9N2I8-1", "uniprot_id": [ { "id": "TRXR2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9N2I8", "type": "external" } ], "mass": 54670.0, "length": 511, "protein_name": "Thioredoxin reductase 2, mitochondrial", "gene_name": "TXNRD2", "organism": "Bovine", "refseq_name": "thioredoxin reductase 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_777051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777051", "type": "external" } ], "gene_names_uniprotkb": "TXNRD2; TRXR2", "gene_names_refseq": "TXNRD2; mt-TR", "protein_names_uniprotkb": "Thioredoxin reductase 2, mitochondrial; 1.8.1.9; Thioredoxin reductase TR3; mt-TR", "protein_names_refseq": "thioredoxin reductase 2, mitochondrial precursor; thioredoxin reductase 2, mitochondrial; thioredoxin reductase TR3", "tax_id": 9913, "disease": "", "pathway": " (bta:282389); (R-BTA-3299685)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10447675", "class_list": "", "function": "Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling., [UniProtKB, PubMed, UniProtKB]; The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.9", "type": "external" }, { "id": "1.11.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.2", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0045454 cell redox homeostasis;GO:0000305 response to oxygen radical", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9N2I8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9SND8-1", "uniprot_id": [ { "id": "A0AAA9SND8_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9SND8", "type": "external" } ], "mass": 79701.0, "length": 723, "protein_name": "Peroxisomal bifunctional enzyme", "gene_name": "EHHADH", "organism": "Bovine", "refseq_name": "peroxisomal bifunctional enzyme", "refseq_ac": [ { "id": "NP_001069248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069248", "type": "external" } ], "gene_names_uniprotkb": "EHHADH", "gene_names_refseq": "EHHADH", "protein_names_uniprotkb": "Peroxisomal bifunctional enzyme; 1.1.1.35; 4.2.1.17; 5.3.3.8; Multifunctional enzyme 1", "protein_names_refseq": "enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; peroxisomal bifunctional enzyme", "tax_id": 9913, "disease": "", "pathway": " (bta:518852); (R-BTA-390247); (R-BTA-9033241)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "1.1.1.211", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.211", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" } ], "go_molecular_function": "GO:0004300 enoyl-CoA hydratase activity;GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity;GO:0003857 (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity;GO:0016509 long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005782 peroxisomal matrix;GO:0005777 peroxisome", "go_biological_process": "GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0006633 fatty acid biosynthetic process;GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9SND8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFP3-1", "uniprot_id": [ { "id": "FADS3_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFP3", "type": "external" } ], "mass": 51306.0, "length": 443, "protein_name": "Fatty acid desaturase 3", "gene_name": "FADS3", "organism": "Bovine", "refseq_name": "fatty acid desaturase 3", "refseq_ac": [ { "id": "NP_001077160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077160", "type": "external" } ], "gene_names_uniprotkb": "FADS3", "gene_names_refseq": "FADS3", "protein_names_uniprotkb": "Fatty acid desaturase 3; 1.14.19.-; Delta(13) desaturase; Delta(13) fatty acid desaturase; FADS3", "protein_names_refseq": "delta(13) desaturase; delta(13) fatty acid desaturase; fatty acid desaturase 3", "tax_id": 9913, "disease": "", "pathway": " (bta:515925)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mammals have different sphingoid bases that differ in their length and/or pattern of desaturation and hydroxyl groups. The predominant sphingoid base that comprises mammalian ceramides is sphing-4-enine (sphingosine or SPH) which has a trans (E) desaturation at carbon 4. FADS3 is a desaturase that introduces a cis (Z) double bond between carbon 14 and carbon 15 of the sphingoid base (also known as long chain base, LCB), producing LCBs such as sphinga-4,14-dienine (SPD, d18:2(4E,14Z)) from SPH. Prefers SPH-containing ceramides (N-acylsphing-4-enines) as substrates. Capable of metabolizing also the SPH in its free form. SPD ceramides occur widely in mammalian tissues and cells. Due to their unusual structure containing a cis double bond, SPD ceramides may have an opposite, negative role in lipid microdomain formation relative to conventional ceramides. Could be involved in the detoxification of 1-deoxy sphingolipids, by desaturating the cytotoxic 1-deoxysphinganine (1-deoxySA, m18:0), produced under pathological conditions, to 1-deoxysphingenine (1-deoxysphingosine, 1-deoxySO, m18:1). Although prefers SPH-containing ceramides (N-acylsphing-4-enines) as substrates, it also exhibits activity toward dihydrosphingosine-containing CERs (N-acylsphinganines) and produces 14Z-SPH-containing sphingolipids. Its desaturase mechanism involves an electron transfer facilitated by cytochrome b5 (By similarity). FADS3 also acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 13 to generate (11E,13Z)-octadecadienoate (also known as conjugated linoleic acid 11E,13Z-CLA) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.-", "type": "external" } ], "go_molecular_function": "GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006665 sphingolipid metabolic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFP3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H767-1", "uniprot_id": [ { "id": "NP1L1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H767", "type": "external" } ], "mass": 45376.0, "length": 391, "protein_name": "Nucleosome assembly protein 1-like 1", "gene_name": "LOC132345080; NAP1L1", "organism": "Bovine", "refseq_name": "nucleosome assembly protein 1-like 1", "refseq_ac": [ { "id": "NP_001092685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092685", "type": "external" } ], "gene_names_uniprotkb": "LOC132345080; NAP1L1", "gene_names_refseq": "NAP1L1", "protein_names_uniprotkb": "Nucleosome assembly protein 1-like 1; Histone H2A-H2B chaperone NAP1L1", "protein_names_refseq": "histone H2A-H2B chaperone NAP1L1; nucleosome assembly protein 1-like 1", "tax_id": 9913, "disease": "", "pathway": " (bta:790872)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Also participates in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Also stimulates homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042470 melanosome;GO:0000785 chromatin", "go_biological_process": "GO:0007399 nervous system development;GO:0006334 nucleosome assembly;GO:2000179 positive regulation of neural precursor cell proliferation;GO:0050769 positive regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H767-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJU9-1", "uniprot_id": [ { "id": "SEPT1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJU9", "type": "external" } ], "mass": 41983.0, "length": 367, "protein_name": "Septin-1", "gene_name": "SEPTIN1", "organism": "Bovine", "refseq_name": "septin-1", "refseq_ac": [ { "id": "NP_001092417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092417", "type": "external" } ], "gene_names_uniprotkb": "SEPTIN1; SEPT1", "gene_names_refseq": "SEPT1; SEPTIN1; Septin-1", "protein_names_uniprotkb": "Septin-1", "protein_names_refseq": "septin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:512478)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)., [UniProtKB]; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005813 centrosome;GO:0015630 microtubule cytoskeleton;GO:0030496 midbody;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0017157 regulation of exocytosis;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJU9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDZ9-1", "uniprot_id": [ { "id": "VAPB_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDZ9", "type": "external" } ], "mass": 27158.0, "length": 243, "protein_name": "Vesicle-associated membrane protein-associated protein B", "gene_name": "VAPB", "organism": "Bovine", "refseq_name": "vesicle-associated membrane protein-associated protein B", "refseq_ac": [ { "id": "NP_001075892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075892", "type": "external" } ], "gene_names_uniprotkb": "VAPB", "gene_names_refseq": "VAPB", "protein_names_uniprotkb": "Vesicle-associated membrane protein-associated protein B; VAMP-B; VAMP-associated protein B; VAP-B", "protein_names_refseq": "VAMP (vesicle-associated membrane protein)-associated protein B and C; VAMP-B; VAMP-associated protein B; VAP-B; vesicle-associated membrane protein-associated protein B", "tax_id": 9913, "disease": "", "pathway": " (bta:326580); (R-BTA-1660661); (R-BTA-8980692); (R-BTA-9013106); (R-BTA-9013404); (R-BTA-9013408)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. Interacts with STARD3 in a FFAT motif phosphorylation dependent manner. Via interaction with WDR44 participates in neosynthesized protein export. Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0090158 endoplasmic reticulum membrane organization;GO:0036498 IRE1-mediated unfolded protein response;GO:0006874 intracellular calcium ion homeostasis;GO:0061817 endoplasmic reticulum-plasma membrane tethering;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDZ9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFA7-1", "uniprot_id": [ { "id": "CBR4_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFA7", "type": "external" } ], "mass": 25269.0, "length": 237, "protein_name": "3-oxoacyl-[acyl-carrier-protein] reductase", "gene_name": "CBR4", "organism": "Bovine", "refseq_name": "3-oxoacyl-[acyl-carrier-protein] reductase", "refseq_ac": [ { "id": "NP_001077186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077186", "type": "external" } ], "gene_names_uniprotkb": "CBR4", "gene_names_refseq": "CBR4", "protein_names_uniprotkb": "3-oxoacyl-[acyl-carrier-protein] reductase; 1.1.1.100; 1.6.5.10; 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; CBR4; Carbonyl reductase family member 4; KAR beta subunit; Quinone reductase CBR4", "protein_names_refseq": "3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; KAR beta subunit; carbonyl reductase family member 4; quinone reductase CBR4", "tax_id": 9913, "disease": "", "pathway": " (bta:533020); (R-BTA-75105)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" } ], "go_molecular_function": "GO:0048038 quinone binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0008753 NADPH dehydrogenase (quinone) activity;GO:0070402 NADPH binding;GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:1990204 oxidoreductase complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006633 fatty acid biosynthetic process;GO:0051290 protein heterotetramerization;GO:0044597 daunorubicin metabolic process;GO:0044598 doxorubicin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFA7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDT1-1", "uniprot_id": [ { "id": "TP4A3_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDT1", "type": "external" } ], "mass": 19511.0, "length": 173, "protein_name": "Protein tyrosine phosphatase type IVA 3", "gene_name": "PTP4A3", "organism": "Bovine", "refseq_name": "protein tyrosine phosphatase type IVA 3", "refseq_ac": [ { "id": "NP_001077235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077235", "type": "external" } ], "gene_names_uniprotkb": "PTP4A3", "gene_names_refseq": "PTP4A3", "protein_names_uniprotkb": "Protein tyrosine phosphatase type IVA 3; 3.1.3.48; Protein-tyrosine phosphatase 4a3", "protein_names_refseq": "protein tyrosine phosphatase type IVA 3; protein tyrosine phosphatase type IVA, member 3", "tax_id": 9913, "disease": "", "pathway": " (bta:100137722)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0043542 endothelial cell migration;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDT1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJX7-1", "uniprot_id": [ { "id": "S6A13_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJX7", "type": "external" } ], "mass": 67788.0, "length": 602, "protein_name": "Sodium- and chloride-dependent GABA transporter 2", "gene_name": "SLC6A13", "organism": "Bovine", "refseq_name": "sodium- and chloride-dependent GABA transporter 2", "refseq_ac": [ { "id": "NP_001092497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092497", "type": "external" } ], "gene_names_uniprotkb": "SLC6A13", "gene_names_refseq": "GAT-2; SLC6A13", "protein_names_uniprotkb": "Sodium- and chloride-dependent GABA transporter 2; GAT-2; Solute carrier family 6 member 13", "protein_names_refseq": "sodium- and chloride-dependent GABA transporter 2; solute carrier family 6 (neurotransmitter transporter, GABA), member 13", "tax_id": 9913, "disease": "", "pathway": " (bta:523784); (R-BTA-442660); (R-BTA-888593)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (By similarity). Can also mediate transport of beta-alanine, taurine and hypotaurine (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0042995 cell projection", "go_biological_process": "GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0006836 neurotransmitter transport;GO:0089718 amino acid import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJX7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7E3U5-1", "uniprot_id": [ { "id": "S38A7_BOVIN", "url": "https://www.uniprot.org/uniprot/A7E3U5", "type": "external" } ], "mass": 49853.0, "length": 463, "protein_name": "Sodium-coupled neutral amino acid transporter 7", "gene_name": "SLC38A7", "organism": "Bovine", "refseq_name": "sodium-coupled neutral amino acid transporter 7", "refseq_ac": [ { "id": "NP_001093825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093825", "type": "external" } ], "gene_names_uniprotkb": "SLC38A7; SNAT7", "gene_names_refseq": "SLC38A7", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid transporter 7; Solute carrier family 38 member 7", "protein_names_refseq": "putative sodium-coupled neutral amino acid transporter 7; sodium-coupled neutral amino acid transporter 7", "tax_id": 9913, "disease": "", "pathway": " (bta:513110)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015186 L-glutamine transmembrane transporter activity;GO:0015182 L-asparagine transmembrane transporter activity;GO:0140901 L-asparagine:sodium symporter activity;GO:0140902 L-glutamine:sodium symporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006868 glutamine transport;GO:0006814 sodium ion transport;GO:0003333 amino acid transmembrane transport;GO:0006867 asparagine transport;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7E3U5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB45-1", "uniprot_id": [ { "id": "ACSS3_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB45", "type": "external" } ], "mass": 74805.0, "length": 686, "protein_name": "Acyl-CoA synthetase short-chain family member 3, mitochondrial", "gene_name": "ACSS3", "organism": "Bovine", "refseq_name": "acyl-CoA synthetase short-chain family member 3, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001095607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095607", "type": "external" } ], "gene_names_uniprotkb": "ACSS3", "gene_names_refseq": "ACSS3", "protein_names_uniprotkb": "Acyl-CoA synthetase short-chain family member 3, mitochondrial; 6.2.1.17; 6.2.1.1; Acetate--CoA ligase 3; Propionate--CoA ligase", "protein_names_refseq": "acetate--CoA ligase 3; acyl-CoA synthetase short-chain family member 3, mitochondrial precursor; acyl-CoA synthetase short-chain family member 3, mitochondrial; propionate--CoA ligase", "tax_id": 9913, "disease": "", "pathway": " (bta:531552); (R-BTA-77111)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (By similarity). Propionate is the preferred substrate but can also utilize acetate and butyrate with a much lower affinity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0003987 acetate-CoA ligase activity;GO:0050218 propionate-CoA ligase activity;GO:0031956 medium-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB45-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE52-1", "uniprot_id": [ { "id": "ORN_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE52", "type": "external" } ], "mass": 26885.0, "length": 237, "protein_name": "Oligoribonuclease, mitochondrial", "gene_name": "REXO2", "organism": "Bovine", "refseq_name": "oligoribonuclease, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001075204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075204", "type": "external" } ], "gene_names_uniprotkb": "REXO2", "gene_names_refseq": "REXO2", "protein_names_uniprotkb": "Oligoribonuclease, mitochondrial; 3.1.15.-; RNA exonuclease 2 homolog; Small fragment nuclease", "protein_names_refseq": "REX2, RNA exonuclease 2 homolog; RNA exonuclease 2 homolog; oligoribonuclease, mitochondrial precursor; oligoribonuclease, mitochondrial; small fragment nuclease", "tax_id": 9913, "disease": "", "pathway": " (bta:540139)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (By similarity). Binds and degrades longer oligonucleotides with a lower affinity (By similarity). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (By similarity). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (By similarity). Essential for embryonic development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0000287 magnesium ion binding;GO:0003676 nucleic acid binding;GO:0008408 3'-5' exonuclease activity;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:2000827 mitochondrial RNA surveillance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VE52-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HLN2-1", "uniprot_id": [ { "id": "CO9A2_BOVIN", "url": "https://www.uniprot.org/uniprot/C0HLN2", "type": "external" } ], "mass": 64963.0, "length": 688, "protein_name": "Collagen alpha-2(IX) chain", "gene_name": "COL9A2", "organism": "Bovine", "refseq_name": "collagen alpha-2(IX) chain", "refseq_ac": [ { "id": "XP_024845989", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845989", "type": "external" } ], "gene_names_uniprotkb": "COL9A2", "gene_names_refseq": "COL9A2", "protein_names_uniprotkb": "Collagen alpha-2(IX) chain; Collagen type IX alpha 2 chain", "protein_names_refseq": "collagen alpha-2(IX) chain", "tax_id": 9913, "disease": "", "pathway": " (bta:505942)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1429648;1599476;19393038;2511833;3609327;8172611;8315278", "class_list": "", "function": "Structural component of hyaline cartilage and vitreous of the eye., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005594 collagen type IX trimer", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "C0HLN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9U0U6-1", "uniprot_id": [ { "id": "A0AAA9U0U6_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9U0U6", "type": "external" } ], "mass": 48192.0, "length": 433, "protein_name": "Long-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "ACADL", "organism": "Bovine", "refseq_name": "long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_024833385", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833385", "type": "external" } ], "gene_names_uniprotkb": "ACADL", "gene_names_refseq": "ACADL", "protein_names_uniprotkb": "Long-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.7; 1.3.8.8; Medium-chain acyl-CoA dehydrogenase, mitochondrial", "protein_names_refseq": "long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.9", "type": "external" }, { "id": "1.3.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.4", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0050660 flavin adenine dinucleotide binding;GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0042758 long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9U0U6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7I4-1", "uniprot_id": [ { "id": "EXT1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7I4", "type": "external" } ], "mass": 86299.0, "length": 746, "protein_name": "Exostosin-1", "gene_name": "EXT1", "organism": "Bovine", "refseq_name": "exostosin-1", "refseq_ac": [ { "id": "NP_001091564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091564", "type": "external" } ], "gene_names_uniprotkb": "EXT1", "gene_names_refseq": "EXT1", "protein_names_uniprotkb": "Exostosin-1; 2.4.1.225; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase", "protein_names_refseq": "Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N- acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostoses protein 1 homolog; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase; exostoses (multiple) 1; exostosin 1; exostosin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:538602); (R-BTA-2022928)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase forming with EXT2 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.224", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.224", "type": "external" }, { "id": "2.4.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.225", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0008375 acetylglucosaminyltransferase activity;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:1902494 catalytic complex", "go_biological_process": "GO:0000271 polysaccharide biosynthetic process;GO:0001503 ossification;GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7I4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQR4-1", "uniprot_id": [ { "id": "ERC6L_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQR4", "type": "external" } ], "mass": 140510.0, "length": 1242, "protein_name": "DNA excision repair protein ERCC-6-like", "gene_name": "ERCC6L", "organism": "Bovine", "refseq_name": "DNA excision repair protein ERCC-6-like", "refseq_ac": [ { "id": "NP_001096000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096000", "type": "external" } ], "gene_names_uniprotkb": "ERCC6L", "gene_names_refseq": "ERCC6L", "protein_names_uniprotkb": "DNA excision repair protein ERCC-6-like; 3.6.4.12; ATP-dependent helicase ERCC6-like", "protein_names_refseq": "ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC-6-like; excision repair cross-complementation group 6-like; excision repair cross-complementing rodent repair deficiency, complementation group 6-like", "tax_id": 9913, "disease": "", "pathway": " (bta:782916); (R-BTA-141430); (R-BTA-141444); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-5663220); (R-BTA-9648025)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8L7", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity;GO:0015616 DNA translocase activity", "go_cellular_component": "GO:0000776 kinetochore", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QQR4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAF6DMC9-1", "uniprot_id": [ { "id": "A0AAF6DMC9_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAF6DMC9", "type": "external" } ], "mass": 31495.0, "length": 266, "protein_name": "Elongation of very long chain fatty acids protein 6", "gene_name": "ELOVL6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ELOVL6", "gene_names_refseq": "", "protein_names_uniprotkb": "Elongation of very long chain fatty acids protein 6; 2.3.1.199; 3-keto acyl-CoA synthase ELOVL6; ELOVL FA elongase 6; ELOVL fatty acid elongase 6; Very long chain 3-ketoacyl-CoA synthase 6; Very long chain 3-oxoacyl-CoA synthase 6", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" } ], "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0009923 fatty acid elongase complex", "go_biological_process": "GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid;GO:0042759 long-chain fatty acid biosynthetic process;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAF6DMC9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDN6-1", "uniprot_id": [ { "id": "SF3A1_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDN6", "type": "external" } ], "mass": 88786.0, "length": 793, "protein_name": "Splicing factor 3A subunit 1", "gene_name": "SF3A1", "organism": "Bovine", "refseq_name": "splicing factor 3A subunit 1", "refseq_ac": [ { "id": "NP_001074979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074979", "type": "external" } ], "gene_names_uniprotkb": "SF3A1", "gene_names_refseq": "SF3A1", "protein_names_uniprotkb": "Splicing factor 3A subunit 1", "protein_names_refseq": "splicing factor 3 subunit 1; splicing factor 3A subunit 1; splicing factor 3a, subunit 1, 120kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:504381); (R-BTA-72163); (R-BTA-9770562); (R-BTA-9943411)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDN6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFM7-1", "uniprot_id": [ { "id": "MYLK2_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFM7", "type": "external" } ], "mass": 67243.0, "length": 623, "protein_name": "Myosin light chain kinase 2, skeletal/cardiac muscle", "gene_name": "MYLK2", "organism": "Bovine", "refseq_name": "myosin light chain kinase 2, skeletal/cardiac muscle", "refseq_ac": [ { "id": "NP_001422058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422058", "type": "external" } ], "gene_names_uniprotkb": "MYLK2", "gene_names_refseq": "MYLK2", "protein_names_uniprotkb": "Myosin light chain kinase 2, skeletal/cardiac muscle; 2.7.11.18; MLCK2", "protein_names_refseq": "MLCK2; myosin light chain kinase 2, skeletal muscle; myosin light chain kinase 2, skeletal/cardiac muscle", "tax_id": 9913, "disease": "", "pathway": " (bta:533378)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ca(2+)/calmodulin-dependent kinase that phosphorylates the regulatory light chain (RLC) of sarcomeric myosin in skeletal and cardiac muscle. Phosphorylation of RLC promotes displacement of myosin cross-bridges from the thick filament backbone toward actin-containing thin filaments, increasing the probability of cross-bridge entry into force-generating states and thereby potentiating contractile force at submaximal Ca(2+) concentrations., [UniProtKB, UniProtKB, UniProtKB]; Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.18", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0032027 myosin light chain binding;GO:0004687 myosin light chain kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0007165 signal transduction;GO:0055008 cardiac muscle tissue morphogenesis;GO:0006941 striated muscle contraction;GO:0014816 skeletal muscle satellite cell differentiation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFM7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN74-1", "uniprot_id": [ { "id": "TRI11_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JN74", "type": "external" } ], "mass": 52947.0, "length": 468, "protein_name": "E3 ubiquitin-protein ligase TRIM11", "gene_name": "TRIM11", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase TRIM11", "refseq_ac": [ { "id": "NP_001071388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071388", "type": "external" } ], "gene_names_uniprotkb": "TRIM11", "gene_names_refseq": "TRIM11", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM11; 2.3.2.27; Tripartite motif-containing protein 11", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM11; RING-type E3 ubiquitin transferase TRIM11; tripartite motif-containing protein 11", "tax_id": 9913, "disease": "", "pathway": " (bta:514580); (R-BTA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (By similarity). Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2. Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005654 nucleoplasm", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0044790 suppression of viral release by host;GO:0046598 positive regulation of viral entry into host cell;GO:0016567 protein ubiquitination;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JN74-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNA8-1", "uniprot_id": [ { "id": "PAXI1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNA8", "type": "external" } ], "mass": 109167.0, "length": 984, "protein_name": "PAX-interacting protein 1", "gene_name": "PAXIP1", "organism": "Bovine", "refseq_name": "PAX-interacting protein 1", "refseq_ac": [ { "id": "NP_001071385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071385", "type": "external" } ], "gene_names_uniprotkb": "PAXIP1", "gene_names_refseq": "PAXIP1", "protein_names_uniprotkb": "PAX-interacting protein 1; PAX transactivation activation domain-interacting protein", "protein_names_refseq": "PAX interacting (with transcription-activation domain) protein 1; PAX transactivation activation domain-interacting protein; PAX-interacting protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:513213); (R-BTA-5693571); (R-BTA-9772755); (R-BTA-9818564)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes. However, this function has been questioned (By similarity). Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0016363 nuclear matrix;GO:0005694 chromosome;GO:0044666 MLL3/4 complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006351 DNA-templated transcription;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNA8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4I1-1", "uniprot_id": [ { "id": "S20A2_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4I1", "type": "external" } ], "mass": 69610.0, "length": 645, "protein_name": "Sodium-dependent phosphate transporter 2", "gene_name": "SLC20A2", "organism": "Bovine", "refseq_name": "sodium-dependent phosphate transporter 2", "refseq_ac": [ { "id": "NP_001073749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073749", "type": "external" } ], "gene_names_uniprotkb": "SLC20A2; PIT2", "gene_names_refseq": "SLC20A2", "protein_names_uniprotkb": "Sodium-dependent phosphate transporter 2; Phosphate transporter 2; PiT-2; Solute carrier family 20 member 2", "protein_names_refseq": "phosphate transporter 2; piT-2; sodium-dependent phosphate transporter 2", "tax_id": 9913, "disease": "", "pathway": " (bta:518905)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion. Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization. Required to maintain normal cerebrospinal fluid phosphate levels. Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005315 phosphate transmembrane transporter activity;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0030501 positive regulation of bone mineralization;GO:0035435 phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4I1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4L5-1", "uniprot_id": [ { "id": "ALKB8_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4L5", "type": "external" } ], "mass": 75193.0, "length": 664, "protein_name": "tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8", "gene_name": "ALKBH8", "organism": "Bovine", "refseq_name": "tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8", "refseq_ac": [ { "id": "NP_001073810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073810", "type": "external" } ], "gene_names_uniprotkb": "ALKBH8", "gene_names_refseq": "ALKBH8", "protein_names_uniprotkb": "tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8; 2.1.1.229; Alkylated DNA repair protein alkB homolog 8; Alpha-ketoglutarate-dependent dioxygenase ALKBH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ALKBH8", "protein_names_refseq": "S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ALKBH8; alkB, alkylation repair homolog 8; alkylated DNA repair protein alkB homolog 8; alpha-ketoglutarate-dependent dioxygenase ALKBH8; probable alpha-ketoglutarate-dependent dioxygenase ABH8; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8", "tax_id": 9913, "disease": "", "pathway": " (bta:781788)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.229", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.229", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0002098 tRNA wobble uridine modification;GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4L5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDL4-1", "uniprot_id": [ { "id": "SATT_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDL4", "type": "external" } ], "mass": 56007.0, "length": 530, "protein_name": "Neutral amino acid transporter A", "gene_name": "SLC1A4", "organism": "Bovine", "refseq_name": "neutral amino acid transporter A", "refseq_ac": [ { "id": "NP_001075046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075046", "type": "external" } ], "gene_names_uniprotkb": "SLC1A4; SATT", "gene_names_refseq": "ASCT1; SLC1A4", "protein_names_uniprotkb": "Neutral amino acid transporter A; Solute carrier family 1 member 4", "protein_names_refseq": "SATT; neutral amino acid transporter A; solute carrier family 1 (glutamate/neutral amino acid transporter), member 4", "tax_id": 9913, "disease": "", "pathway": " (bta:326577); (R-BTA-352230)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (By similarity). Exchanges neutral amino acids such as L- and D-serine, L-threonine, L-asparagine and L-alanine in a bidirectional way (By similarity). Involved in homeostasis of D-serine, a coagonist of synaptic NMDA receptors. In astrocytes at excitatory synapses, mediates electrogenic D-serine influx coupled to L-serine efflux and L-serine shuttling to neurons for de novo D-serine synthesis (By similarity). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) > NO3(-) > I(-) > Cl(-) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0015195 L-threonine transmembrane transporter activity;GO:0046872 metal ion binding;GO:0015194 L-serine transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0033162 melanosome membrane;GO:0016020 membrane;GO:0005813 centrosome;GO:0005882 intermediate filament", "go_biological_process": "GO:0015825 L-serine transport;GO:0015813 L-glutamate transmembrane transport;GO:1902475 L-alpha-amino acid transmembrane transport;GO:0015824 proline transport;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDL4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE01-1", "uniprot_id": [ { "id": "CLP1_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE01", "type": "external" } ], "mass": 47630.0, "length": 425, "protein_name": "Polyribonucleotide 5'-hydroxyl-kinase Clp1", "gene_name": "CLP1", "organism": "Bovine", "refseq_name": "polyribonucleotide 5'-hydroxyl-kinase Clp1", "refseq_ac": [ { "id": "NP_001075182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075182", "type": "external" } ], "gene_names_uniprotkb": "CLP1", "gene_names_refseq": "CLP1", "protein_names_uniprotkb": "Polyribonucleotide 5'-hydroxyl-kinase Clp1; 2.7.1.78; Polyadenylation factor Clp1; Polynucleotide kinase Clp1; Pre-mRNA cleavage complex II protein Clp1", "protein_names_refseq": "CLP1, cleavage and polyadenylation factor I subunit, homolog; cleavage and polyadenylation factor I subunit 1; polyadenylation factor Clp1; polynucleotide kinase Clp1; polyribonucleotide 5'-hydroxyl-kinase Clp1; pre-mRNA cleavage complex II protein Clp1", "tax_id": 9913, "disease": "", "pathway": " (bta:506507); (R-BTA-73856); (R-BTA-77595); (R-BTA-9770562)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0051736 ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity;GO:0005524 ATP binding;GO:0051731 polynucleotide 5'-hydroxyl-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005849 mRNA cleavage factor complex;GO:0000214 tRNA-intron endonuclease complex", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0021695 cerebellar cortex development;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0000379 tRNA-type intron splice site recognition and cleavage;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VE01-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE39-1", "uniprot_id": [ { "id": "CMTR1_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE39", "type": "external" } ], "mass": 95142.0, "length": 835, "protein_name": "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1", "gene_name": "CMTR1", "organism": "Bovine", "refseq_name": "cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1", "refseq_ac": [ { "id": "NP_001075899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075899", "type": "external" } ], "gene_names_uniprotkb": "CMTR1; FTSJD2", "gene_names_refseq": "CMTR1; FTSJD2; MTr1", "protein_names_uniprotkb": "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; 2.1.1.57; Cap methyltransferase 1; Cap1 2'O-ribose methyltransferase 1; FtsJ methyltransferase domain-containing protein 2; MTr1", "protein_names_refseq": "FtsJ methyltransferase domain containing 2; cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; cap1 2'O-ribose methyltransferase 1; ftsJ methyltransferase domain-containing protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:509620)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.57", "type": "external" } ], "go_molecular_function": "GO:0004483 methyltransferase cap1 activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0032259 methylation;GO:0006370 7-methylguanosine mRNA capping;GO:0016556 mRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VE39-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE99-1", "uniprot_id": [ { "id": "SEP11_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE99", "type": "external" } ], "mass": 48992.0, "length": 425, "protein_name": "Septin-11", "gene_name": "SEPTIN11", "organism": "Bovine", "refseq_name": "septin-11", "refseq_ac": [ { "id": "NP_001075916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075916", "type": "external" } ], "gene_names_uniprotkb": "SEPTIN11; SEPT11", "gene_names_refseq": "SEPT11; SEPTIN11", "protein_names_uniprotkb": "Septin-11", "protein_names_refseq": "septin-11", "tax_id": 9913, "disease": "", "pathway": " (bta:535746)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity)., [UniProtKB]; Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0030424 axon;GO:0043197 dendritic spine;GO:0015630 microtubule cytoskeleton;GO:0031105 septin complex", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VE99-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3FPG8-1", "uniprot_id": [ { "id": "GPAT4_BOVIN", "url": "https://www.uniprot.org/uniprot/A3FPG8", "type": "external" } ], "mass": 52055.0, "length": 456, "protein_name": "Glycerol-3-phosphate acyltransferase 4", "gene_name": "GPAT4", "organism": "Bovine", "refseq_name": "glycerol-3-phosphate acyltransferase 4 precursor", "refseq_ac": [ { "id": "NP_001077138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077138", "type": "external" } ], "gene_names_uniprotkb": "GPAT4; AGPAT6", "gene_names_refseq": "AGPAT6; GPAT4", "protein_names_uniprotkb": "Glycerol-3-phosphate acyltransferase 4; 1-AGP acyltransferase 6; 1-AGPAT 6; 1-acylglycerol-3-phosphate O-acyltransferase 6; 2.3.1.15; Acyl-CoA:glycerol-3-phosphate acyltransferase 4; GPAT4; LPAAT-zeta; Lysophosphatidic acid acyltransferase zeta", "protein_names_refseq": "1-AGP acyltransferase 6; 1-AGPAT 6; 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); LPAAT-zeta; acyl-CoA:glycerol-3-phosphate acyltransferase 4; glycerol-3-phosphate acyltransferase 4 precursor; lysophosphatidic acid acyltransferase zeta", "tax_id": 9913, "disease": "", "pathway": " (bta:511614)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18492828;24465687", "class_list": "", "function": "Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Active against both saturated and unsaturated long-chain fatty acyl-CoAs. Protects cells against lipotoxicity., [UniProtKB, UniProtKB]; The results of this study suggest that suggest that SLC27A6, ACSL1, FABP3, AGPAT6, and LPIN1 coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary., [RefSeq, PubMed]; Variants affecting the expression of AGPAT6 are causally involved in differential milk fat synthesis, with pleiotropic consequences for a diverse range of other milk components. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" } ], "go_molecular_function": "GO:0004366 glycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A3FPG8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KFF6-1", "uniprot_id": [ { "id": "WBP2L_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KFF6", "type": "external" } ], "mass": 31966.0, "length": 313, "protein_name": "Postacrosomal sheath WW domain-binding protein", "gene_name": "WBP2NL", "organism": "Bovine", "refseq_name": "postacrosomal sheath WW domain-binding protein", "refseq_ac": [ { "id": "NP_001075910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075910", "type": "external" } ], "gene_names_uniprotkb": "WBP2NL; PAWP", "gene_names_refseq": "WBP2NL", "protein_names_uniprotkb": "Postacrosomal sheath WW domain-binding protein; WW domain-binding protein 2-like", "protein_names_refseq": "PAWP; WW domain-binding protein 2-like; postacrosomal sheath WW domain-binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:523070)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17289678;24488940", "class_list": "", "function": "May play a role in meiotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization., [UniProtKB, PubMed]; PAWP correlates with semen/fertility parameters used in the cattle artificial insemination industry, making PAWP a potential biomarker of bull fertility., [RefSeq, PubMed]; PAWP is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during fertilization, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0050699 WW domain binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0061827 sperm head;GO:0005634 nucleus;GO:0036126 sperm flagellum;GO:0033011 perinuclear theca", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0035038 female pronucleus assembly;GO:0035039 male pronucleus assembly;GO:0007343 egg activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A3KFF6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KMV5-1", "uniprot_id": [ { "id": "UBA1_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KMV5", "type": "external" } ], "mass": 117830.0, "length": 1058, "protein_name": "Ubiquitin-like modifier-activating enzyme 1", "gene_name": "UBA1", "organism": "Bovine", "refseq_name": "ubiquitin-like modifier-activating enzyme 1", "refseq_ac": [ { "id": "NP_001095947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095947", "type": "external" } ], "gene_names_uniprotkb": "UBA1; UBE1", "gene_names_refseq": "UBA1; UBE1X; UBE1", "protein_names_uniprotkb": "Ubiquitin-like modifier-activating enzyme 1; 6.2.1.45; Ubiquitin-activating enzyme E1", "protein_names_refseq": "ubiquitin-activating enzyme E1; ubiquitin-like modifier-activating enzyme 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282869); (R-BTA-8866652); (R-BTA-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004839 ubiquitin activating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006974 DNA damage response;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KMV5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KMX0-1", "uniprot_id": [ { "id": "ER6L2_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KMX0", "type": "external" } ], "mass": 175090.0, "length": 1546, "protein_name": "DNA excision repair protein ERCC-6-like 2", "gene_name": "ERCC6L2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ERCC6L2", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA excision repair protein ERCC-6-like 2; 3.6.4.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Promotes double-strand break (DSB) end-joining and facilitates programmed recombination by controlling how DNA ends are joined in a spatially oriented manner during repair (By similarity). Also plays a role in DNA repair by restricting DNA end resection in double strand break (DSB) repair. Facilitates replication of complex DNA regions and regulates the maintenance of chromatin structure (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0004386 helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:0006974 DNA damage response;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KMX0-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KMX8-1", "uniprot_id": [ { "id": "ARMT1_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KMX8", "type": "external" } ], "mass": 50964.0, "length": 441, "protein_name": "Damage-control phosphatase 1", "gene_name": "DCPH1", "organism": "Bovine", "refseq_name": "damage-control phosphatase 1", "refseq_ac": [ { "id": "NP_001076968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076968", "type": "external" } ], "gene_names_uniprotkb": "DCPH1; ARMT1", "gene_names_refseq": "ARMT1; C9H6orf211; DCPH1", "protein_names_uniprotkb": "Damage-control phosphatase 1; 2.1.1.-; 3.1.3.-; Acidic residue methyltransferase 1; Protein-glutamate O-methyltransferase; Sugar phosphate phosphatase ARMT1", "protein_names_refseq": "UPF0364 protein C6orf211 homolog; damage-control phosphatase 1; damage-control phosphatase ARMT1; protein-glutamate O-methyltransferase; sugar phosphate phosphatase ARMT1", "tax_id": 9913, "disease": "", "pathway": " (bta:540698)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.1.3.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.25", "type": "external" }, { "id": "3.1.3.94", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.94", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0051998 protein carboxyl O-methyltransferase activity;GO:0016791 phosphatase activity;GO:0097023 fructose 6-phosphate aldolase activity", "go_cellular_component": "", "go_biological_process": "GO:0006974 DNA damage response;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KMX8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KMY4-1", "uniprot_id": [ { "id": "CTL4_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KMY4", "type": "external" } ], "mass": 78938.0, "length": 707, "protein_name": "Choline transporter-like protein 4", "gene_name": "SLC44A4", "organism": "Bovine", "refseq_name": "choline transporter-like protein 4", "refseq_ac": [ { "id": "NP_001076911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076911", "type": "external" } ], "gene_names_uniprotkb": "SLC44A4; CTL4; TPPT1", "gene_names_refseq": "CTL4; SLC44A4", "protein_names_uniprotkb": "Choline transporter-like protein 4; Solute carrier family 44 member 4; Thiamine pyrophosphate transporter 1", "protein_names_refseq": "choline transporter-like protein 4; thiamine pyrophosphate transporter 1", "tax_id": 9913, "disease": "", "pathway": " (bta:520625); (R-BTA-1483191); (R-BTA-9958517)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0015220 choline transmembrane transporter activity;GO:0090422 thiamine pyrophosphate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0008292 acetylcholine biosynthetic process;GO:0015871 choline transport;GO:0030974 thiamine pyrophosphate transmembrane transport;GO:0032475 otolith formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KMY4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KN12-1", "uniprot_id": [ { "id": "PUR8_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KN12", "type": "external" } ], "mass": 55484.0, "length": 490, "protein_name": "Adenylosuccinate lyase", "gene_name": "ADSL", "organism": "Bovine", "refseq_name": "adenylosuccinate lyase", "refseq_ac": [ { "id": "NP_001095847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095847", "type": "external" } ], "gene_names_uniprotkb": "ADSL", "gene_names_refseq": "ADSL", "protein_names_uniprotkb": "Adenylosuccinate lyase; 4.3.2.2; ADSL; ASL; ASase; Adenylosuccinase", "protein_names_refseq": "ASL; ASase; adenylosuccinase; adenylosuccinate lyase", "tax_id": 9913, "disease": "", "pathway": " (bta:510949)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.2", "type": "external" } ], "go_molecular_function": "GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity;GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006189 'de novo' IMP biosynthetic process;GO:0044208 'de novo' AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KN12-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KN19-1", "uniprot_id": [ { "id": "FA83D_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KN19", "type": "external" } ], "mass": 63396.0, "length": 581, "protein_name": "Protein FAM83D", "gene_name": "FAM83D", "organism": "Bovine", "refseq_name": "protein FAM83D", "refseq_ac": [ { "id": "NP_001076862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076862", "type": "external" } ], "gene_names_uniprotkb": "FAM83D", "gene_names_refseq": "FAM83D", "protein_names_uniprotkb": "Protein FAM83D", "protein_names_refseq": "protein FAM83D", "tax_id": 9913, "disease": "", "pathway": " (bta:508561)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (By similarity). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (By similarity). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097431 mitotic spindle pole", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0007165 signal transduction;GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KN19-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KN22-1", "uniprot_id": [ { "id": "UBC12_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KN22", "type": "external" } ], "mass": 20900.0, "length": 183, "protein_name": "NEDD8-conjugating enzyme Ubc12", "gene_name": "UBE2M", "organism": "Bovine", "refseq_name": "NEDD8-conjugating enzyme Ubc12", "refseq_ac": [ { "id": "NP_001076972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076972", "type": "external" } ], "gene_names_uniprotkb": "UBE2M; UBC12", "gene_names_refseq": "UBE2M", "protein_names_uniprotkb": "NEDD8-conjugating enzyme Ubc12; 2.3.2.34; NEDD8 carrier protein; Ubiquitin-conjugating enzyme E2 M", "protein_names_refseq": "NEDD8 carrier protein; NEDD8 protein ligase; NEDD8-conjugating enzyme Ubc12; ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)", "tax_id": 9913, "disease": "", "pathway": " (bta:613343); (R-BTA-2173789); (R-BTA-8951664); (R-BTA-983168)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0061654 NEDD8 conjugating enzyme activity;GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0019788 NEDD8 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0036211 protein modification process;GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KN22-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUD3-1", "uniprot_id": [ { "id": "U5S1_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUD3", "type": "external" } ], "mass": 109386.0, "length": 972, "protein_name": "116 kDa U5 small nuclear ribonucleoprotein component", "gene_name": "EFTUD2", "organism": "Bovine", "refseq_name": "116 kDa U5 small nuclear ribonucleoprotein component", "refseq_ac": [ { "id": "NP_001076865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076865", "type": "external" } ], "gene_names_uniprotkb": "EFTUD2; SNRP116", "gene_names_refseq": "EFTUD2", "protein_names_uniprotkb": "116 kDa U5 small nuclear ribonucleoprotein component; Elongation factor Tu GTP-binding domain protein 2; U5 snRNP-specific protein, 116 kDa; U5-116 kDa", "protein_names_refseq": "116 kDa U5 small nuclear ribonucleoprotein component; U5 snRNP-specific protein, 116 kDa; U5-116 kDa; elongation factor Tu GTP-binding domain protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:509425)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030623 U5 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0071007 U2-type catalytic step 2 spliceosome;GO:0046540 U4/U6 x U5 tri-snRNP complex;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUD3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUD4-1", "uniprot_id": [ { "id": "PEX12_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUD4", "type": "external" } ], "mass": 40766.0, "length": 359, "protein_name": "Peroxisome assembly protein 12", "gene_name": "PEX12", "organism": "Bovine", "refseq_name": "peroxisome assembly protein 12", "refseq_ac": [ { "id": "XP_010814094", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814094", "type": "external" } ], "gene_names_uniprotkb": "PEX12", "gene_names_refseq": "PEX12", "protein_names_uniprotkb": "Peroxisome assembly protein 12; Peroxin-12", "protein_names_refseq": "peroxisome assembly protein 12", "tax_id": 9913, "disease": "", "pathway": " (bta:506007); (R-BTA-8866654); (R-BTA-9033241); (R-BTA-9603798)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity;GO:1990757 ubiquitin ligase activator activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0007031 peroxisome organization;GO:0000209 protein polyubiquitination;GO:0034614 cellular response to reactive oxygen species;GO:0016558 protein import into peroxisome matrix;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUD4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUD9-1", "uniprot_id": [ { "id": "MCM3_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUD9", "type": "external" } ], "mass": 90858.0, "length": 808, "protein_name": "DNA replication licensing factor MCM3", "gene_name": "MCM3", "organism": "Bovine", "refseq_name": "DNA replication licensing factor MCM3", "refseq_ac": [ { "id": "NP_001013604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013604", "type": "external" } ], "gene_names_uniprotkb": "MCM3", "gene_names_refseq": "MCM3", "protein_names_uniprotkb": "DNA replication licensing factor MCM3; 3.6.4.12", "protein_names_refseq": "DNA replication licensing factor MCM3; MCM3 minichromosome maintenance deficient 3", "tax_id": 9913, "disease": "", "pathway": " (bta:281302); (R-BTA-176187); (R-BTA-68867); (R-BTA-68949); (R-BTA-68962); (R-BTA-69052)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006271 DNA strand elongation involved in DNA replication;GO:1902975 mitotic DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUD9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUI2-1", "uniprot_id": [ { "id": "RUXE_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUI2", "type": "external" } ], "mass": 10804.0, "length": 92, "protein_name": "Small nuclear ribonucleoprotein E", "gene_name": "SNRPE", "organism": "Bovine", "refseq_name": "small nuclear ribonucleoprotein E", "refseq_ac": [ { "id": "NP_001076928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076928", "type": "external" } ], "gene_names_uniprotkb": "SNRPE", "gene_names_refseq": "SNRPE", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein E; Sm protein E; Sm-E; SmE; snRNP-E", "protein_names_refseq": "sm protein E; sm-E; smE; small nuclear ribonucleoprotein E; snRNP-E", "tax_id": 9913, "disease": "", "pathway": " (bta:531493)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005829 cytosol;GO:0034709 methylosome;GO:0005686 U2 snRNP", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUI2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUY1-1", "uniprot_id": [ { "id": "HECAM_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUY1", "type": "external" } ], "mass": 46057.0, "length": 418, "protein_name": "Hepatic and glial cell adhesion molecule", "gene_name": "HEPACAM", "organism": "Bovine", "refseq_name": "hepatic and glial cell adhesion molecule precursor", "refseq_ac": [ { "id": "NP_001026929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026929", "type": "external" } ], "gene_names_uniprotkb": "HEPACAM", "gene_names_refseq": "HEPACAM", "protein_names_uniprotkb": "Hepatic and glial cell adhesion molecule; Hepatocyte cell adhesion molecule; Protein hepaCAM; glialCAM", "protein_names_refseq": "glialCAM; hepatic and glial cell adhesion molecule precursor; hepatocyte cell adhesion molecule; protein hepaCAM", "tax_id": 9913, "disease": "", "pathway": " (bta:521015)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (By similarity). In glia, associates and targets CLCN2 at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux involved in neuron excitability., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q58DG9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0097450 astrocyte end-foot", "go_biological_process": "GO:0006955 immune response;GO:0007155 cell adhesion;GO:0051726 regulation of cell cycle;GO:0150105 protein localization to cell-cell junction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4FUY1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV27-1", "uniprot_id": [ { "id": "LAMP5_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV27", "type": "external" } ], "mass": 31528.0, "length": 280, "protein_name": "Lysosome-associated membrane glycoprotein 5", "gene_name": "LAMP5", "organism": "Bovine", "refseq_name": "lysosome-associated membrane glycoprotein 5 precursor", "refseq_ac": [ { "id": "NP_001076887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076887", "type": "external" } ], "gene_names_uniprotkb": "LAMP5", "gene_names_refseq": "C13H20orf103; LAMP-5; LAMP5", "protein_names_uniprotkb": "Lysosome-associated membrane glycoprotein 5; LAMP-5; Lysosome-associated membrane protein 5", "protein_names_refseq": "LAMP family protein C20orf103 homolog; UPF0710 protein C20orf103 homolog; lysosome-associated membrane glycoprotein 5 precursor; lysosome-associated membrane glycoprotein 5; lysosome-associated membrane protein 5", "tax_id": 9913, "disease": "", "pathway": " (bta:513094)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0072594 establishment of protein localization to organelle;GO:0099171 presynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV27-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV48-1", "uniprot_id": [ { "id": "FADS2_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV48", "type": "external" } ], "mass": 52533.0, "length": 444, "protein_name": "Acyl-CoA 6-desaturase", "gene_name": "FADS2", "organism": "Bovine", "refseq_name": "acyl-CoA 6-desaturase", "refseq_ac": [ { "id": "NP_001076913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076913", "type": "external" } ], "gene_names_uniprotkb": "FADS2", "gene_names_refseq": "FADS2", "protein_names_uniprotkb": "Acyl-CoA 6-desaturase; 1.14.19.3; D6D; Delta(6) desaturase; Delta(6) fatty acid desaturase; Delta-6 desaturase; Fatty acid desaturase 2", "protein_names_refseq": "D6D; acyl-CoA 6-desaturase; delta(6) desaturase; delta-6 fatty acid desaturase", "tax_id": 9913, "disease": "", "pathway": " (bta:521822); (R-BTA-2046105); (R-BTA-2046106)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate, a metabolite in the biohydrogenation pathway of LA and the predominant trans fatty acid in cow milk) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.19.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.3", "type": "external" } ], "go_molecular_function": "GO:0004768 stearoyl-CoA 9-desaturase activity;GO:0016213 acyl-CoA 6-desaturase activity;GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006636 unsaturated fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV48-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV68-1", "uniprot_id": [ { "id": "2A5E_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV68", "type": "external" } ], "mass": 54699.0, "length": 467, "protein_name": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform", "gene_name": "PPP2R5E", "organism": "Bovine", "refseq_name": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform", "refseq_ac": [ { "id": "NP_001076937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076937", "type": "external" } ], "gene_names_uniprotkb": "PPP2R5E", "gene_names_refseq": "PPP2R5E", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform; PP2A B subunit isoform B'-epsilon; PP2A B subunit isoform B56-epsilon; PP2A B subunit isoform PR61-epsilon; PP2A B subunit isoform R5-epsilon", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform", "tax_id": 9913, "disease": "", "pathway": " (bta:533617); (R-BTA-141430); (R-BTA-141444); (R-BTA-195253); (R-BTA-196299); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-389356); (R-BTA-389513); (R-BTA-432142); (R-BTA-4641262); (R-BTA-5663220); (R-BTA-5673000); (R-BTA-5675221); (R-BTA-6811558); (R-BTA-9648025)", "pathway_count": 16, "publication_count": 1, "publication_id_list": "12912990", "class_list": "", "function": "The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0072542 protein phosphatase activator activity;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4FV68-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV72-1", "uniprot_id": [ { "id": "PPIE_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV72", "type": "external" } ], "mass": 33461.0, "length": 301, "protein_name": "Peptidyl-prolyl cis-trans isomerase E", "gene_name": "PPIE", "organism": "Bovine", "refseq_name": "peptidyl-prolyl cis-trans isomerase E", "refseq_ac": [ { "id": "NP_001091630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091630", "type": "external" } ], "gene_names_uniprotkb": "PPIE", "gene_names_refseq": "PPIE", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase E; 5.2.1.8; Cyclophilin E; PPIase E; Rotamase E", "protein_names_refseq": "PPIase E; cyclophilin E; peptidyl-prolyl cis-trans isomerase E; rotamase E", "tax_id": 9913, "disease": "", "pathway": " (bta:787681)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0016018 cyclosporin A binding;GO:0008143 poly(A) binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0071007 U2-type catalytic step 2 spliceosome", "go_biological_process": "GO:0006457 protein folding;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV72-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IF63-1", "uniprot_id": [ { "id": "TRIM2_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IF63", "type": "external" } ], "mass": 81476.0, "length": 744, "protein_name": "Tripartite motif-containing protein 2", "gene_name": "TRIM2", "organism": "Bovine", "refseq_name": "tripartite motif-containing protein 2", "refseq_ac": [ { "id": "NP_001077204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077204", "type": "external" } ], "gene_names_uniprotkb": "TRIM2", "gene_names_refseq": "TRIM2", "protein_names_uniprotkb": "Tripartite motif-containing protein 2; 2.3.2.27; E3 ubiquitin-protein ligase TRIM2; RING-type E3 ubiquitin transferase TRIM2", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM2; RING-type E3 ubiquitin transferase TRIM2; tripartite motif-containing protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:538617)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0043523 regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IF63-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IF97-1", "uniprot_id": [ { "id": "ML12B_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IF97", "type": "external" } ], "mass": 19692.0, "length": 171, "protein_name": "Myosin regulatory light chain 12B", "gene_name": "MYL12B", "organism": "Bovine", "refseq_name": "myosin regulatory light chain 12B", "refseq_ac": [ { "id": "NP_001077233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077233", "type": "external" } ], "gene_names_uniprotkb": "MYL12B; MRLC2; MYLC2B", "gene_names_refseq": "MRLC2; MYL12B", "protein_names_uniprotkb": "Myosin regulatory light chain 12B; MLC20; Myosin regulatory light chain 2-B, smooth muscle isoform; Myosin regulatory light chain 20 kDa; Myosin regulatory light chain MRLC2", "protein_names_refseq": "MLC20; myosin regulatory light chain 12B; myosin regulatory light chain 20 kDa; myosin regulatory light chain MRCL2; myosin regulatory light chain MRLC2", "tax_id": 9913, "disease": "", "pathway": " (bta:614055); (R-BTA-445355); (R-BTA-5627123)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0032036 myosin heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005903 brush border;GO:0005938 cell cortex;GO:0001725 stress fiber;GO:0030018 Z disc", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IF97-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFK7-1", "uniprot_id": [ { "id": "RIPL2_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFK7", "type": "external" } ], "mass": 23435.0, "length": 206, "protein_name": "RILP-like protein 2", "gene_name": "RILPL2", "organism": "Bovine", "refseq_name": "RILP-like protein 2", "refseq_ac": [ { "id": "NP_001077187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077187", "type": "external" } ], "gene_names_uniprotkb": "RILPL2", "gene_names_refseq": "RILPL2", "protein_names_uniprotkb": "RILP-like protein 2; Rab-interacting lysosomal-like protein 2", "protein_names_refseq": "RILP-like protein 2; rab-interacting lysosomal-like protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:533228)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0031267 small GTPase binding;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0060271 cilium assembly;GO:0003382 epithelial cell morphogenesis;GO:1903445 protein transport from ciliary membrane to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFK7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFN5-1", "uniprot_id": [ { "id": "FITM2_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFN5", "type": "external" } ], "mass": 29716.0, "length": 262, "protein_name": "Acyl-coenzyme A diphosphatase FITM2", "gene_name": "FITM2", "organism": "Bovine", "refseq_name": "acyl-coenzyme A diphosphatase FITM2", "refseq_ac": [ { "id": "NP_001096565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096565", "type": "external" } ], "gene_names_uniprotkb": "FITM2; FIT2", "gene_names_refseq": "FIT2; FITM2", "protein_names_uniprotkb": "Acyl-coenzyme A diphosphatase FITM2; 3.6.1.-; Fat storage-inducing transmembrane protein 2; Fat-inducing protein 2", "protein_names_refseq": "Fat-inducing protein 2; acyl-coenzyme A diphosphatase FITM2; fat-inducing transcript protein", "tax_id": 9913, "disease": "", "pathway": " (bta:518159); (R-BTA-8964572)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl-CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0017129 triglyceride binding;GO:0019992 diacylglycerol binding;GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0055088 lipid homeostasis;GO:0045444 fat cell differentiation;GO:0019915 lipid storage;GO:0034389 lipid droplet organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFN5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7B2-1", "uniprot_id": [ { "id": "CLM9_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7B2", "type": "external" } ], "mass": 27988.0, "length": 255, "protein_name": "CMRF35-like molecule 9", "gene_name": "CD300LG", "organism": "Bovine", "refseq_name": "CMRF35-like molecule 9 isoform X9", "refseq_ac": [ { "id": "XP_005221013", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221013", "type": "external" } ], "gene_names_uniprotkb": "CD300LG; CLM9", "gene_names_refseq": "CD300LG", "protein_names_uniprotkb": "CMRF35-like molecule 9; CD300 antigen-like family member G; CLM-9", "protein_names_refseq": "CMRF35-like molecule 9 isoform X9", "tax_id": 9913, "disease": "", "pathway": " (bta:615388); (R-BTA-198933)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity)., [UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 1, "predicted_o_glycosites": 11, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0032585 multivesicular body membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7B2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7H3-1", "uniprot_id": [ { "id": "CTL2_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7H3", "type": "external" } ], "mass": 80027.0, "length": 706, "protein_name": "Choline transporter-like protein 2", "gene_name": "SLC44A2", "organism": "Bovine", "refseq_name": "choline transporter-like protein 2", "refseq_ac": [ { "id": "NP_001091608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091608", "type": "external" } ], "gene_names_uniprotkb": "SLC44A2; CTL2", "gene_names_refseq": "SLC44A2", "protein_names_uniprotkb": "Choline transporter-like protein 2; Solute carrier family 44 member 2", "protein_names_refseq": "choline transporter-like protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:617624); (R-BTA-1483191); (R-BTA-6798163); (R-BTA-6798695); (R-BTA-9958517)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Choline transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Choline/H+ antiporter, mainly in mitochondria. Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015220 choline transmembrane transporter activity;GO:0034228 ethanolamine transmembrane transporter activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015871 choline transport;GO:0034229 ethanolamine transport;GO:0015695 organic cation transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7H3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7M3-1", "uniprot_id": [ { "id": "DRC4_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7M3", "type": "external" } ], "mass": 56049.0, "length": 478, "protein_name": "Dynein regulatory complex subunit 4", "gene_name": "DRC4", "organism": "Bovine", "refseq_name": "dynein regulatory complex subunit 4", "refseq_ac": [ { "id": "NP_001091038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091038", "type": "external" } ], "gene_names_uniprotkb": "DRC4; GAS8", "gene_names_refseq": "DRC4; GAS8", "protein_names_uniprotkb": "Dynein regulatory complex subunit 4; GAS-8; Growth arrest-specific protein 8", "protein_names_refseq": "GAS-8; dynein regulatory complex subunit 4; growth arrest-specific protein 8", "tax_id": 9913, "disease": "", "pathway": " (bta:504318)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0031514 motile cilium;GO:0036126 sperm flagellum", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0030317 flagellated sperm motility;GO:0035082 axoneme assembly;GO:1903566 positive regulation of protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7M3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7P0-1", "uniprot_id": [ { "id": "MPIP3_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7P0", "type": "external" } ], "mass": 53794.0, "length": 477, "protein_name": "M-phase inducer phosphatase 3", "gene_name": "CDC25C", "organism": "Bovine", "refseq_name": "M-phase inducer phosphatase 3", "refseq_ac": [ { "id": "NP_001091465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091465", "type": "external" } ], "gene_names_uniprotkb": "CDC25C", "gene_names_refseq": "CDC25C", "protein_names_uniprotkb": "M-phase inducer phosphatase 3; 3.1.3.48; Dual specificity phosphatase Cdc25C", "protein_names_refseq": "Dual specificity phosphatase Cdc25C; M-phase inducer phosphatase 3; cell division cycle 25 homolog C", "tax_id": 9913, "disease": "", "pathway": " (bta:507731); (R-BTA-156711); (R-BTA-5625740); (R-BTA-6804115); (R-BTA-69273); (R-BTA-75035)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity;GO:0050699 WW domain binding;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005758 mitochondrial intermembrane space;GO:0016607 nuclear speck", "go_biological_process": "GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0110032 positive regulation of G2/MI transition of meiotic cell cycle;GO:1902751 positive regulation of cell cycle G2/M phase transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7P0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7Q3-1", "uniprot_id": [ { "id": "SEP12_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7Q3", "type": "external" } ], "mass": 41210.0, "length": 361, "protein_name": "Septin-12", "gene_name": "SEPTIN12", "organism": "Bovine", "refseq_name": "septin-12", "refseq_ac": [ { "id": "NP_001091612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091612", "type": "external" } ], "gene_names_uniprotkb": "SEPTIN12; SEPT12", "gene_names_refseq": "SEPT12; SEPTIN12", "protein_names_uniprotkb": "Septin-12", "protein_names_refseq": "septin-12", "tax_id": 9913, "disease": "", "pathway": " (bta:618676)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (By similarity). Facilitates the formation of Septin filament structures with SEPTIN7, SEPTIN6, SEPTIN2 and SEPTIN4 at the sperm annulus (By similarity). Correct formation of the annulus is required for development of normal structural morphology and motility of the sperm during steps 13 to 16 of spermiogenesis (By similarity). Essential component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during spermiogenesis (By similarity). Required for PLCZ1 localization at the sperm acrosome during spermiogenesis (By similarity). May also play a role in the initiation of calcium oscillations in embryos (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0035091 phosphatidylinositol binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005940 septin ring;GO:0005819 spindle;GO:0048471 perinuclear region of cytoplasm;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7Q3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7R8-1", "uniprot_id": [ { "id": "KITH_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7R8", "type": "external" } ], "mass": 26377.0, "length": 238, "protein_name": "Thymidine kinase, cytosolic", "gene_name": "TK1", "organism": "Bovine", "refseq_name": "thymidine kinase, cytosolic", "refseq_ac": [ { "id": "NP_001091041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091041", "type": "external" } ], "gene_names_uniprotkb": "TK1", "gene_names_refseq": "TK1", "protein_names_uniprotkb": "Thymidine kinase, cytosolic; 2.7.1.21", "protein_names_refseq": "thymidine kinase 1, soluble; thymidine kinase, cytosolic", "tax_id": 9913, "disease": "", "pathway": " (bta:504652)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Cell-cycle-regulated enzyme of importance in nucleotide metabolism. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7E3S3", "ec_number_list": [ { "id": "2.7.1.74", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.74", "type": "external" }, { "id": "2.7.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.21", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004797 thymidine kinase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0046104 thymidine metabolic process;GO:0051289 protein homotetramerization;GO:0046105 thymidine biosynthetic process;GO:1904860 DNA synthesis involved in mitotic DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5D7R8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7U4-1", "uniprot_id": [ { "id": "SCNNB_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7U4", "type": "external" } ], "mass": 72677.0, "length": 641, "protein_name": "Epithelial sodium channel subunit beta", "gene_name": "SCNN1B", "organism": "Bovine", "refseq_name": "epithelial sodium channel subunit beta", "refseq_ac": [ { "id": "NP_001091544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091544", "type": "external" } ], "gene_names_uniprotkb": "SCNN1B", "gene_names_refseq": "SCNEB; SCNN1B", "protein_names_uniprotkb": "Epithelial sodium channel subunit beta; Amiloride-sensitive sodium channel subunit beta; Beta-ENaC; Beta-NaCH; Epithelial Na(+) channel subunit beta; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB", "protein_names_refseq": "amiloride-sensitive sodium channel subunit beta; beta-ENaC; beta-NaCH; epithelial Na(+) channel subunit beta; epithelial sodium channel subunit beta; nonvoltage-gated sodium channel 1 subunit beta; sodium channel epithelial 1 beta subunit; sodium channel, non-voltage-gated 1, beta subunit; sodium channel, nonvoltage-gated 1, beta (Liddle syndrome)", "tax_id": 9913, "disease": "", "pathway": " (bta:533355); (R-BTA-2672351); (R-BTA-9730628)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "F1MZB9", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0050699 WW domain binding;GO:0015280 ligand-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0034706 sodium channel complex", "go_biological_process": "GO:0006883 intracellular sodium ion homeostasis;GO:0035725 sodium ion transmembrane transport;GO:0098719 sodium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5D7U4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7V7-1", "uniprot_id": [ { "id": "S46A3_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7V7", "type": "external" } ], "mass": 51303.0, "length": 461, "protein_name": "Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3", "gene_name": "SLC46A3", "organism": "Bovine", "refseq_name": "lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 precursor", "refseq_ac": [ { "id": "NP_001096773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096773", "type": "external" } ], "gene_names_uniprotkb": "SLC46A3", "gene_names_refseq": "SLC46A3", "protein_names_uniprotkb": "Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3; Solute carrier family 46 member 3", "protein_names_refseq": "lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 precursor; lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3", "tax_id": 9913, "disease": "", "pathway": " (bta:781117)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm (By similarity). Modulates hepatic cytosolic copper homeostasis, maybe acting as a lysosomal copper transporter and sequestering copper ions in the lysosome (By similarity). Delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Selectively transports bacterial muramyl dipeptide (MDP) into the cytosol for recognition by NOD2, triggering inflammatory responses (By similarity). Likely acts as a redundant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages. The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane", "go_biological_process": "GO:0034486 vacuolar transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7V7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D9A7-1", "uniprot_id": [ { "id": "CYAC3_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D9A7", "type": "external" } ], "mass": 29803.0, "length": 265, "protein_name": "Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3", "gene_name": "CYB561A3", "organism": "Bovine", "refseq_name": "lysosomal membrane ascorbate-dependent ferrireductase CYB561A3", "refseq_ac": [ { "id": "NP_001092619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092619", "type": "external" } ], "gene_names_uniprotkb": "CYB561A3", "gene_names_refseq": "CYB561A3; CYBASC3", "protein_names_uniprotkb": "Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3; 7.2.1.3; Cytochrome b ascorbate-dependent protein 3; LCytb; Lysosomal cytochrome b", "protein_names_refseq": "LCytb; cytochrome b ascorbate-dependent protein 3; cytochrome b, ascorbate dependent 3; lysosomal cytochrome b; lysosomal membrane ascorbate-dependent ferrireductase CYB561A3", "tax_id": 9913, "disease": "", "pathway": " (bta:615893)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0140571 transmembrane ascorbate ferrireductase activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5D9A7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJA1-1", "uniprot_id": [ { "id": "KAD6_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJA1", "type": "external" } ], "mass": 19927.0, "length": 172, "protein_name": "Adenylate kinase isoenzyme 6", "gene_name": "AK6", "organism": "Bovine", "refseq_name": "adenylate kinase isoenzyme 6", "refseq_ac": [ { "id": "NP_001099078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099078", "type": "external" } ], "gene_names_uniprotkb": "AK6; CINAP", "gene_names_refseq": "AK/ATPase; AK6", "protein_names_uniprotkb": "Adenylate kinase isoenzyme 6; 2.7.4.3; AK/ATPase; AK6; Coilin-interacting nuclear ATPase protein; Dual activity adenylate kinase/ATPase", "protein_names_refseq": "ATP-AMP transphosphorylase 6; adenylate kinase isoenzyme 6; coilin-interacting nuclear ATPase protein; dual activity adenylate kinase/ATPase", "tax_id": 9913, "disease": "", "pathway": " (bta:102216273); (R-BTA-499943)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Also has ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis. May be involved in regulation of Cajal body (CB) formation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0015030 Cajal body;GO:0016607 nuclear speck", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJA1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJC4-1", "uniprot_id": [ { "id": "UB2L6_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJC4", "type": "external" } ], "mass": 17825.0, "length": 153, "protein_name": "Ubiquitin/ISG15-conjugating enzyme E2 L6", "gene_name": "UBE2L6", "organism": "Bovine", "refseq_name": "ubiquitin/ISG15-conjugating enzyme E2 L6", "refseq_ac": [ { "id": "NP_001092387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092387", "type": "external" } ], "gene_names_uniprotkb": "UBE2L6", "gene_names_refseq": "UBE2L6; UbcM8", "protein_names_uniprotkb": "Ubiquitin/ISG15-conjugating enzyme E2 L6; 2.3.2.23; E2 ubiquitin-conjugating enzyme L6; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme L6; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6; ubiquitin-conjugating enzyme E2L 6; ubiquitin/ISG15-conjugating enzyme E2 L6", "tax_id": 9913, "disease": "", "pathway": " (bta:509471); (R-BTA-1169408); (R-BTA-5656169); (R-BTA-936440); (R-BTA-983168); (R-BTA-9833482); (R-BTA-9909505)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042296 ISG15 transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0032020 ISG15-protein conjugation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJC4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJI6-1", "uniprot_id": [ { "id": "CAVN4_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJI6", "type": "external" } ], "mass": 41161.0, "length": 361, "protein_name": "Caveolae-associated protein 4", "gene_name": "CAVIN4", "organism": "Bovine", "refseq_name": "caveolae-associated protein 4", "refseq_ac": [ { "id": "NP_001096734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096734", "type": "external" } ], "gene_names_uniprotkb": "CAVIN4; MURC", "gene_names_refseq": "CAVIN4; MURC", "protein_names_uniprotkb": "Caveolae-associated protein 4; Muscle-related coiled-coil protein; Muscle-restricted coiled-coil protein", "protein_names_refseq": "caveolae-associated protein 4; muscle related coiled-coil protein; muscle-restricted coiled-coil protein", "tax_id": 9913, "disease": "", "pathway": " (bta:528386)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes. Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7YVI0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005901 caveola;GO:0042383 sarcolemma", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0007517 muscle organ development;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJI6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJT0-1", "uniprot_id": [ { "id": "MBLC2_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJT0", "type": "external" } ], "mass": 31257.0, "length": 279, "protein_name": "Acyl-coenzyme A thioesterase MBLAC2", "gene_name": "MBLAC2", "organism": "Bovine", "refseq_name": "acyl-coenzyme A thioesterase MBLAC2", "refseq_ac": [ { "id": "NP_001092549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092549", "type": "external" } ], "gene_names_uniprotkb": "MBLAC2", "gene_names_refseq": "MBLAC2", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase MBLAC2; 3.1.2.2; 3.5.2.6; Acyl-CoA thioesterase MBLAC2; Beta-lactamase MBLAC2; Metallo-beta-lactamase domain-containing protein 2; Palmitoyl-coenzyme A thioesterase MBLAC2", "protein_names_refseq": "acyl-CoA thioesterase MBLAC2; acyl-coenzyme A thioesterase MBLAC2; beta-lactamase MBLAC2; metallo-beta-lactamase domain-containing protein 2; palmitoyl-coenzyme A thioesterase MBLAC2", "tax_id": 9913, "disease": "", "pathway": " (bta:537692)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.4.13.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.19", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0052816 long-chain fatty acyl-CoA hydrolase activity;GO:0008800 beta-lactamase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJT0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJV0-1", "uniprot_id": [ { "id": "MAFG_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJV0", "type": "external" } ], "mass": 17877.0, "length": 162, "protein_name": "Transcription factor MafG", "gene_name": "MAFG", "organism": "Bovine", "refseq_name": "transcription factor MafG", "refseq_ac": [ { "id": "NP_001092450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092450", "type": "external" } ], "gene_names_uniprotkb": "MAFG", "gene_names_refseq": "MAFG", "protein_names_uniprotkb": "Transcription factor MafG; V-maf musculoaponeurotic fibrosarcoma oncogene homolog G", "protein_names_refseq": "transcription factor MafG", "tax_id": 9913, "disease": "", "pathway": " (bta:515219); (R-BTA-983231)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin gene expression when associated with NFE2L2 (By similarity). May be involved in signal transduction of extracellular H(+) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045604 regulation of epidermal cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJV0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK13-1", "uniprot_id": [ { "id": "LRC8C_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK13", "type": "external" } ], "mass": 92319.0, "length": 803, "protein_name": "Volume-regulated anion channel subunit LRRC8C", "gene_name": "LRRC8C", "organism": "Bovine", "refseq_name": "volume-regulated anion channel subunit LRRC8C", "refseq_ac": [ { "id": "NP_001092509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092509", "type": "external" } ], "gene_names_uniprotkb": "LRRC8C", "gene_names_refseq": "LRRC8C", "protein_names_uniprotkb": "Volume-regulated anion channel subunit LRRC8C; Leucine-rich repeat-containing protein 8C", "protein_names_refseq": "Leucine-rich repeat-containing protein 8C; leucine rich repeat containing 8 family member C; volume-regulated anion channel subunit LRRC8C", "tax_id": 9913, "disease": "", "pathway": " (bta:527708); (R-BTA-5223345)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005225 volume-sensitive anion channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0034214 protein hexamerization;GO:0015810 aspartate transmembrane transport;GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PK13-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK27-1", "uniprot_id": [ { "id": "R144B_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK27", "type": "external" } ], "mass": 33725.0, "length": 304, "protein_name": "E3 ubiquitin-protein ligase RNF144B", "gene_name": "RNF144B", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase RNF144B", "refseq_ac": [ { "id": "NP_001092498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092498", "type": "external" } ], "gene_names_uniprotkb": "RNF144B", "gene_names_refseq": "RNF144B", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF144B; 2.3.2.31; RING finger protein 144B", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF144B; ring finger 144B", "tax_id": 9913, "disease": "", "pathway": " (bta:524166)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Plays a crucial role in maintaining the genomic stability by controlling the degradation of multiple proteins involved in mitotic progression and DNA damage. Regulates epithelial homeostasis by mediating degradation of CDKN1A and isoform 2 of TP63. Plays a regulatory role in innate immunity by negatively regulating IRF3 activation and IFN-beta production. Mechanistically, inhibits TBK1 phosphorylation and 'Lys-63'-linked polyubiquitination independently of its E3 ligase activity. Alternatively, promotes 'Lys-27' and 'Lys-33'-linked ubiquitination of IFIH1/MDA5, promoting selective autophagic degradation of IFIH1/MDA5 to inhibit antiviral response., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031966 mitochondrial membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PK27-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK39-1", "uniprot_id": [ { "id": "TPP2_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK39", "type": "external" } ], "mass": 138361.0, "length": 1249, "protein_name": "Tripeptidyl-peptidase 2", "gene_name": "TPP2", "organism": "Bovine", "refseq_name": "tripeptidyl-peptidase 2", "refseq_ac": [ { "id": "NP_001092504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092504", "type": "external" } ], "gene_names_uniprotkb": "TPP2", "gene_names_refseq": "TPP-2; TPP2", "protein_names_uniprotkb": "Tripeptidyl-peptidase 2; 3.4.14.10; TPP-2; TPP-II; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase II", "protein_names_refseq": "TPP-II; tripeptidyl aminopeptidase; tripeptidyl-peptidase 2; tripeptidyl-peptidase II", "tax_id": 9913, "disease": "", "pathway": " (bta:526052)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It plays an important role in intracellular amino acid homeostasis (By similarity). Stimulates adipogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008240 tripeptidyl-peptidase activity;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PK39-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK61-1", "uniprot_id": [ { "id": "H3C_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK61", "type": "external" } ], "mass": 15376.0, "length": 136, "protein_name": "Histone H3.3C", "gene_name": "H3-5", "organism": "Bovine", "refseq_name": "histone H3.3C", "refseq_ac": [ { "id": "NP_001092840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092840", "type": "external" } ], "gene_names_uniprotkb": "H3-5", "gene_names_refseq": "H3-5; H3F3C", "protein_names_uniprotkb": "Histone H3.3C", "protein_names_refseq": "histone H3.3C", "tax_id": 9913, "disease": "", "pathway": " (bta:512741)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007080 mitotic metaphase chromosome alignment;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PK61-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK71-1", "uniprot_id": [ { "id": "PACRG_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK71", "type": "external" } ], "mass": 29284.0, "length": 257, "protein_name": "Parkin coregulated gene protein", "gene_name": "PACRG", "organism": "Bovine", "refseq_name": "parkin coregulated gene protein isoform 1", "refseq_ac": [ { "id": "NP_001422012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422012", "type": "external" } ], "gene_names_uniprotkb": "PACRG", "gene_names_refseq": "PACRG", "protein_names_uniprotkb": "Parkin coregulated gene protein", "protein_names_refseq": "PARK2 co-regulated; parkin coregulated gene protein isoform 1; parkin coregulated gene protein", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "19393038;34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:34715025, PubMed:37327785). Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0001664 G protein-coupled receptor binding;GO:0031625 ubiquitin protein ligase binding;GO:0048487 beta-tubulin binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005829 cytosol;GO:0043005 neuron projection;GO:0044297 cell body;GO:0031982 vesicle", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A5PK71-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H750-1", "uniprot_id": [ { "id": "KIF2B_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H750", "type": "external" } ], "mass": 76907.0, "length": 683, "protein_name": "Kinesin-like protein KIF2B", "gene_name": "KIF2B", "organism": "Bovine", "refseq_name": "kinesin-like protein KIF2B", "refseq_ac": [ { "id": "NP_001094651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094651", "type": "external" } ], "gene_names_uniprotkb": "KIF2B", "gene_names_refseq": "KIF2B", "protein_names_uniprotkb": "Kinesin-like protein KIF2B", "protein_names_refseq": "kinesin-like protein KIF2B", "tax_id": 9913, "disease": "", "pathway": " (bta:538921)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement during mitosis. Has microtubule depolymerization activity. Plays a role in chromosome congression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0007019 microtubule depolymerization;GO:0051983 regulation of chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H750-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H751-1", "uniprot_id": [ { "id": "FOLC_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H751", "type": "external" } ], "mass": 64900.0, "length": 585, "protein_name": "Folylpolyglutamate synthase, mitochondrial", "gene_name": "FPGS", "organism": "Bovine", "refseq_name": "folylpolyglutamate synthase, mitochondrial", "refseq_ac": [ { "id": "NP_001019651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019651", "type": "external" } ], "gene_names_uniprotkb": "FPGS", "gene_names_refseq": "FPGS", "protein_names_uniprotkb": "Folylpolyglutamate synthase, mitochondrial; 6.3.2.17; FPGS; Folylpoly-gamma-glutamate synthetase; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase", "protein_names_refseq": "folylpoly-gamma-glutamate synthetase; folylpolyglutamate synthase, mitochondrial; tetrahydrofolate synthase; tetrahydrofolylpolyglutamate synthase", "tax_id": 9913, "disease": "", "pathway": " (bta:505809)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004326 tetrahydrofolylpolyglutamate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H751-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H791-1", "uniprot_id": [ { "id": "TRM61_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H791", "type": "external" } ], "mass": 31047.0, "length": 285, "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A", "gene_name": "TRMT61A", "organism": "Bovine", "refseq_name": "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A", "refseq_ac": [ { "id": "NP_001092397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092397", "type": "external" } ], "gene_names_uniprotkb": "TRMT61A; TRM61", "gene_names_refseq": "GCD14; TRM61; TRMT61A", "protein_names_uniprotkb": "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; 2.1.1.-; 2.1.1.220; mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A; tRNA(m1A58)-methyltransferase subunit TRMT61A; tRNA(m1A58)MTase subunit TRMT61A", "protein_names_refseq": "mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A; tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A; tRNA methyltransferase 61 homolog A; tRNA(m1A58)-methyltransferase subunit TRM61; tRNA(m1A58)-methyltransferase subunit TRMT61A; tRNA(m1A58)MTase subunit TRM61; tRNA(m1A58)MTase subunit TRMT61A", "tax_id": 9913, "disease": "", "pathway": " (bta:510283)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16043508", "class_list": "", "function": "Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries., [UniProtKB, UniProtKB]; Shows conservation of yeast TRM61 (GCD14) in mouse, human and Drosophila, and demonstrates functional activity of the human ortholog., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.220", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.220", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.218", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218", "type": "external" }, { "id": "2.1.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221", "type": "external" } ], "go_molecular_function": "GO:0061953 mRNA (adenine-N1-)-methyltransferase activity;GO:0160107 tRNA (adenine(58)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031515 tRNA (m1A) methyltransferase complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6H791-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H795-1", "uniprot_id": [ { "id": "UBE2W_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H795", "type": "external" } ], "mass": 17331.0, "length": 151, "protein_name": "Ubiquitin-conjugating enzyme E2 W", "gene_name": "UBE2W", "organism": "Bovine", "refseq_name": "ubiquitin-conjugating enzyme E2 W", "refseq_ac": [ { "id": "NP_001092592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092592", "type": "external" } ], "gene_names_uniprotkb": "UBE2W", "gene_names_refseq": "UBE2W", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 W; 2.3.2.23; 2.3.2.25; E2 ubiquitin-conjugating enzyme W; N-terminal E2 ubiquitin-conjugating enzyme; N-terminus-conjugating E2; Ubiquitin carrier protein W; Ubiquitin-protein ligase W", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme W; N-terminal E2 ubiquitin-conjugating enzyme; N-terminus-conjugating E2; ubiquitin carrier protein W; ubiquitin conjugating enzyme E2 W (putative); ubiquitin-conjugating enzyme E2 W; ubiquitin-conjugating enzyme E2W (putative); ubiquitin-protein ligase W", "tax_id": 9913, "disease": "", "pathway": " (bta:613423); (R-BTA-8866652); (R-BTA-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination also occurs in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0071218 cellular response to misfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H795-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6N9I4-1", "uniprot_id": [ { "id": "GRP2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6N9I4", "type": "external" } ], "mass": 69180.0, "length": 608, "protein_name": "RAS guanyl-releasing protein 2", "gene_name": "RASGRP2", "organism": "Bovine", "refseq_name": "RAS guanyl-releasing protein 2", "refseq_ac": [ { "id": "NP_001093416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093416", "type": "external" } ], "gene_names_uniprotkb": "RASGRP2", "gene_names_refseq": "CalDAG-GEFI; RASGRP2", "protein_names_uniprotkb": "RAS guanyl-releasing protein 2; CalDAG-GEFI; Calcium and DAG-regulated guanine nucleotide exchange factor I", "protein_names_refseq": "RAS guanyl releasing protein 2 (calcium and DAG-regulated); RAS guanyl-releasing protein 2; calcium and DAG-regulated guanine nucleotide exchange factor I; calcium diacylglycerol guanine nucleotide exchange factor I", "tax_id": 9913, "disease": "", "pathway": " (bta:512056); (R-BTA-354192); (R-BTA-392517)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "18039909", "class_list": "", "function": "Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This amino acid substitution is likely responsible for the thrombopathic phenotype observed in Simmental cattle and underscores the critical nature of this signal transduction protein in platelets, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0043005 neuron projection;GO:0032587 ruffle membrane", "go_biological_process": "GO:0007265 Ras protein signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6N9I4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLF8-1", "uniprot_id": [ { "id": "TM108_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLF8", "type": "external" } ], "mass": 60785.0, "length": 583, "protein_name": "Transmembrane protein 108", "gene_name": "TMEM108", "organism": "Bovine", "refseq_name": "transmembrane protein 108 precursor", "refseq_ac": [ { "id": "NP_001095409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095409", "type": "external" } ], "gene_names_uniprotkb": "TMEM108", "gene_names_refseq": "TMEM108", "protein_names_uniprotkb": "Transmembrane protein 108; Retrolinkin", "protein_names_refseq": "retrolinkin; transmembrane protein 108 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:511034)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0030425 dendrite;GO:0010008 endosome membrane", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0031175 neuron projection development;GO:0098815 modulation of excitatory postsynaptic potential;GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLF8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLL0-1", "uniprot_id": [ { "id": "PLIN5_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLL0", "type": "external" } ], "mass": 50198.0, "length": 456, "protein_name": "Perilipin-5", "gene_name": "PLIN5", "organism": "Bovine", "refseq_name": "perilipin-5", "refseq_ac": [ { "id": "NP_001094606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094606", "type": "external" } ], "gene_names_uniprotkb": "PLIN5; LSDP5", "gene_names_refseq": "LSDP5; PLIN5", "protein_names_uniprotkb": "Perilipin-5; Lipid storage droplet protein 5", "protein_names_refseq": "lipid storage droplet protein 5; perilipin-5", "tax_id": 9913, "disease": "", "pathway": " (bta:531199)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0035473 lipase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0010884 positive regulation of lipid storage;GO:0031999 negative regulation of fatty acid beta-oxidation;GO:2000378 negative regulation of reactive oxygen species metabolic process;GO:0060192 negative regulation of lipase activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLL0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLR3-1", "uniprot_id": [ { "id": "ABRX2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLR3", "type": "external" } ], "mass": 46138.0, "length": 409, "protein_name": "BRISC complex subunit Abraxas 2", "gene_name": "ABRAXAS2", "organism": "Bovine", "refseq_name": "BRISC complex subunit Abraxas 2", "refseq_ac": [ { "id": "NP_001160059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160059", "type": "external" } ], "gene_names_uniprotkb": "ABRAXAS2; ABRO1; FAM175B", "gene_names_refseq": "ABRAXAS2; FAM175B", "protein_names_uniprotkb": "BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B", "protein_names_refseq": "BRISC complex subunit Abraxas 2; BRISC complex subunit Abro1; abraxas brother protein 1; family with sequence similarity 175 member B", "tax_id": 9913, "disease": "", "pathway": " (bta:510233)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0070552 BRISC complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0002931 response to ischemia;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLR3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLU6-1", "uniprot_id": [ { "id": "AGRD1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLU6", "type": "external" } ], "mass": 99812.0, "length": 902, "protein_name": "Adhesion G protein-coupled receptor D1", "gene_name": "ADGRD1", "organism": "Bovine", "refseq_name": "adhesion G-protein coupled receptor D1 precursor", "refseq_ac": [ { "id": "NP_001029736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029736", "type": "external" } ], "gene_names_uniprotkb": "ADGRD1; GPR133", "gene_names_refseq": "ADGRD1; GPR133", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor D1; G protein-coupled receptor 133", "protein_names_refseq": "G protein-coupled receptor 133; adhesion G-protein coupled receptor D1 precursor; probable G-protein coupled receptor 133", "tax_id": 9913, "disease": "", "pathway": " (bta:528174)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Adhesion G protein-coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens. Also activated by methenolone drug. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength., [UniProtKB, UniProtKB]; Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens. Also activated by methenolone drug. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 16, "predicted_n_glycosites": 15, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q58DJ5", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0014819 regulation of skeletal muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QLU6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLZ1-1", "uniprot_id": [ { "id": "HUMMR_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLZ1", "type": "external" } ], "mass": 24888.0, "length": 240, "protein_name": "Protein MGARP", "gene_name": "MGARP", "organism": "Bovine", "refseq_name": "protein MGARP", "refseq_ac": [ { "id": "NP_001160083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160083", "type": "external" } ], "gene_names_uniprotkb": "MGARP; CESP1; HUMMR; OSAP", "gene_names_refseq": "C17H4orf49; CESP-1; MGARP; OSAP", "protein_names_uniprotkb": "Protein MGARP; CESP-1; Corneal endothelium-specific protein 1; Hypoxia up-regulated mitochondrial movement regulator protein; Mitochondria-localized glutamic acid-rich protein; Ovary-specific acidic protein", "protein_names_refseq": "corneal endothelium-specific protein 1; hypoxia up-regulated mitochondrial movement regulator protein; ovary-specific acidic protein; protein MGARP", "tax_id": 9913, "disease": "", "pathway": " (bta:513234)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). Plays an inhibitory role during neocortex development by regulating mitochondrial morphology, distribution and motility in neocortical neurons (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0021987 cerebral cortex development;GO:0071456 cellular response to hypoxia;GO:0006626 protein targeting to mitochondrion;GO:0008089 anterograde axonal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLZ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QM06-1", "uniprot_id": [ { "id": "SCAP_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QM06", "type": "external" } ], "mass": 139701.0, "length": 1278, "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein", "gene_name": "SCAP", "organism": "Bovine", "refseq_name": "sterol regulatory element-binding protein cleavage-activating protein", "refseq_ac": [ { "id": "NP_001095359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095359", "type": "external" } ], "gene_names_uniprotkb": "SCAP", "gene_names_refseq": "SCAP", "protein_names_uniprotkb": "Sterol regulatory element-binding protein cleavage-activating protein; SCAP; SREBP cleavage-activating protein", "protein_names_refseq": "SREBP cleavage-activating protein; sterol regulatory element-binding protein cleavage-activating protein", "tax_id": 9913, "disease": "", "pathway": " (bta:507878)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29383471;31953015", "class_list": "", "function": "Although the knockdown of PKM2 had no effect on MAC-T cell growth, the reduced expression of PKM2 attenuated the mRNA and protein expression of key enzymes involved in sterol synthesis through the SREBP pathway., [RefSeq, PubMed]; Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity). Binds cholesterol via its SSD domain (By similarity)., [UniProtKB, UniProtKB]; Lipidomic profiling analysis of the phospholipid molecules in SCAP-induced lipid droplet formation in bovine mammary epithelial cells., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032934 sterol binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0032936 SREBP-SCAP complex", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0008203 cholesterol metabolic process;GO:0045540 regulation of cholesterol biosynthetic process;GO:0032933 SREBP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A6QM06-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNK1-1", "uniprot_id": [ { "id": "G3ST1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNK1", "type": "external" } ], "mass": 48754.0, "length": 423, "protein_name": "Galactosylceramide sulfotransferase", "gene_name": "GAL3ST1", "organism": "Bovine", "refseq_name": "galactosylceramide sulfotransferase", "refseq_ac": [ { "id": "NP_001095442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095442", "type": "external" } ], "gene_names_uniprotkb": "GAL3ST1", "gene_names_refseq": "GAL3ST1", "protein_names_uniprotkb": "Galactosylceramide sulfotransferase; 2.8.2.11; 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase; 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase; Cerebroside sulfotransferase; GalCer sulfotransferase", "protein_names_refseq": "3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase; 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase; cerebroside sulfotransferase; galCer sulfotransferase; galactosylceramide sulfotransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:513295)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the transfer of a sulfate group to position 3 of non-reducing beta-galactosyl residues in glycerolipids and sphingolipids, therefore participates in the biosynthesis of sulfoglycolipids. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.11", "type": "external" } ], "go_molecular_function": "GO:0001733 galactosylceramide sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0042552 myelination;GO:0006682 galactosylceramide biosynthetic process;GO:0006681 galactosylceramide metabolic process;GO:0046486 glycerolipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QNK1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNQ6-1", "uniprot_id": [ { "id": "CTIP_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNQ6", "type": "external" } ], "mass": 85265.0, "length": 757, "protein_name": "DNA endonuclease RBBP8", "gene_name": "RBBP8", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RBBP8; CTIP", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA endonuclease RBBP8; 3.1.-.-; CtBP-interacting protein; CtIP; RBBP-8; RIM; Retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; SAE2; Sporulation in the absence of SPO11 protein 2 homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:512977); (R-BTA-5685938); (R-BTA-5685939); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5693568); (R-BTA-5693579); (R-BTA-5693607); (R-BTA-5693616); (R-BTA-6804756); (R-BTA-69473)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (By similarity). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1BLK8", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003684 damaged DNA binding;GO:0004519 endonuclease activity;GO:0003677 DNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0035861 site of double-strand break", "go_biological_process": "GO:0051301 cell division;GO:0000724 double-strand break repair via homologous recombination;GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing;GO:0051321 meiotic cell cycle;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QNQ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNR0-1", "uniprot_id": [ { "id": "HEXD_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNR0", "type": "external" } ], "mass": 39284.0, "length": 346, "protein_name": "Hexosaminidase D", "gene_name": "HEXD", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HEXD; HEXDC", "gene_names_refseq": "", "protein_names_uniprotkb": "Hexosaminidase D; 3.2.1.52; Beta-N-acetylhexosaminidase; Beta-hexosaminidase D; Hexosaminidase domain-containing protein; N-acetyl-beta-galactosaminidase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015929 hexosaminidase activity;GO:0004563 beta-N-acetylhexosaminidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QNR0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNW6-1", "uniprot_id": [ { "id": "S26A8_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNW6", "type": "external" } ], "mass": 108744.0, "length": 960, "protein_name": "Testis anion transporter 1", "gene_name": "SLC26A8", "organism": "Bovine", "refseq_name": "testis anion transporter 1", "refseq_ac": [ { "id": "NP_001095600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095600", "type": "external" } ], "gene_names_uniprotkb": "SLC26A8", "gene_names_refseq": "SLC26A8", "protein_names_uniprotkb": "Testis anion transporter 1; Anion exchange transporter; Solute carrier family 26 member 8", "protein_names_refseq": "anion exchange transporter; testis anion transporter 1", "tax_id": 9913, "disease": "", "pathway": " (bta:530509)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane. Stimulates anion transport activity of CFTR (By similarity). May cooperate with CFTR in the regulation of chloride and bicarbonate ions fluxes required for activation of the ADCY10/PKA pathway during sperm motility and sperm capacitation. May play a role in sperm tail differentiation and motility and hence male fertility (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity;GO:0160044 sulfate:chloride antiporter activity", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005886 plasma membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QNW6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNY1-1", "uniprot_id": [ { "id": "CD320_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNY1", "type": "external" } ], "mass": 26935.0, "length": 255, "protein_name": "CD320 antigen", "gene_name": "CD320", "organism": "Bovine", "refseq_name": "CD320 antigen precursor", "refseq_ac": [ { "id": "NP_001160030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160030", "type": "external" } ], "gene_names_uniprotkb": "CD320", "gene_names_refseq": "CD320; TCblR", "protein_names_uniprotkb": "CD320 antigen; TCblR; Transcobalamin receptor", "protein_names_refseq": "CD320 antigen precursor; CD320 antigen; transcobalamin receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:505043)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as a costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030890 positive regulation of B cell proliferation;GO:0016192 vesicle-mediated transport;GO:0015889 cobalamin transport;GO:0031296 B cell costimulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QNY1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QP01-1", "uniprot_id": [ { "id": "SELT_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QP01", "type": "external" } ], "mass": 22248.0, "length": 195, "protein_name": "Thioredoxin reductase-like selenoprotein T", "gene_name": "SELENOT", "organism": "Bovine", "refseq_name": "thioredoxin reductase-like selenoprotein T precursor", "refseq_ac": [ { "id": "NP_001096573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096573", "type": "external" } ], "gene_names_uniprotkb": "SELENOT", "gene_names_refseq": "SELENOT; SELT", "protein_names_uniprotkb": "Thioredoxin reductase-like selenoprotein T; 1.8.1.9; SelT", "protein_names_refseq": "thioredoxin reductase-like enzyme; thioredoxin reductase-like selenoprotein T precursor; thioredoxin reductase-like selenoprotein T", "tax_id": 9913, "disease": "", "pathway": " (bta:783831)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress and cell death (By similarity). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Selenoprotein with thioredoxin reductase-like oxidoreductase activity. Protects dopaminergic neurons against oxidative stress and cell death. Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion. Plays a role in fibroblast anchorage and redox regulation. In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation. In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.9", "type": "external" }, { "id": "1.11.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.2", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0042593 glucose homeostasis;GO:0031016 pancreas development;GO:0009749 response to glucose;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QP01-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QP57-1", "uniprot_id": [ { "id": "TGM3_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QP57", "type": "external" } ], "mass": 76791.0, "length": 691, "protein_name": "Protein-glutamine gamma-glutamyltransferase E", "gene_name": "TGM3", "organism": "Bovine", "refseq_name": "protein-glutamine gamma-glutamyltransferase E", "refseq_ac": [ { "id": "NP_001095318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095318", "type": "external" } ], "gene_names_uniprotkb": "TGM3", "gene_names_refseq": "TG(E); TGE; TGM3", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase E; 2.3.2.13; TG(E); TGE; TGase E; TGase-3; Transglutaminase E; Transglutaminase-3", "protein_names_refseq": "E polypeptide, protein-glutamine-gamma-glutamyltransferase; TGase E; TGase-3; protein-glutamine gamma-glutamyltransferase E; transglutaminase E", "tax_id": 9913, "disease": "", "pathway": " (bta:505080)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.5.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0031424 keratinization;GO:0030216 keratinocyte differentiation;GO:0018149 peptide cross-linking", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QP57-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QP74-1", "uniprot_id": [ { "id": "CALRL_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QP74", "type": "external" } ], "mass": 53387.0, "length": 462, "protein_name": "Calcitonin gene-related peptide type 1 receptor", "gene_name": "CALCRL", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CALCRL; CGRPR", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; Calcitonin receptor-like receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:527140)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004948 calcitonin receptor activity;GO:0001605 adrenomedullin receptor activity;GO:0001635 calcitonin gene-related peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QP74-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPH1-1", "uniprot_id": [ { "id": "PYM1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPH1", "type": "external" } ], "mass": 22663.0, "length": 203, "protein_name": "Partner of Y14 and mago", "gene_name": "PYM1", "organism": "Bovine", "refseq_name": "partner of Y14 and mago", "refseq_ac": [ { "id": "NP_001095814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095814", "type": "external" } ], "gene_names_uniprotkb": "PYM1; PYM; WIBG", "gene_names_refseq": "PYM1; WIBG", "protein_names_uniprotkb": "Partner of Y14 and mago; PYM homolog 1 exon junction complex-associated factor; Protein wibg homolog", "protein_names_refseq": "partner of Y14 and mago; protein wibg homolog; within bgcn homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:787259)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0035145 exon-exon junction complex", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045727 positive regulation of translation;GO:1903259 exon-exon junction complex disassembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QPH1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPI1-1", "uniprot_id": [ { "id": "S35A5_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPI1", "type": "external" } ], "mass": 48142.0, "length": 425, "protein_name": "UDP-sugar transporter protein SLC35A5", "gene_name": "SLC35A5", "organism": "Bovine", "refseq_name": "UDP-sugar transporter protein SLC35A5", "refseq_ac": [ { "id": "NP_001069493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069493", "type": "external" } ], "gene_names_uniprotkb": "SLC35A5", "gene_names_refseq": "SLC35A5", "protein_names_uniprotkb": "UDP-sugar transporter protein SLC35A5; Solute carrier family 35 member A5", "protein_names_refseq": "UDP-sugar transporter protein SLC35A5; probable UDP-sugar transporter protein SLC35A5", "tax_id": 9913, "disease": "", "pathway": " (bta:534488)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Probable UDP-sugar:UMP transmembrane antiporter involved in UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport from the cytosol to the lumen of the Golgi., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8M4", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QPI1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPL4-1", "uniprot_id": [ { "id": "KIF22_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPL4", "type": "external" } ], "mass": 73202.0, "length": 662, "protein_name": "Kinesin-like protein KIF22", "gene_name": "KIF22", "organism": "Bovine", "refseq_name": "kinesin-like protein KIF22", "refseq_ac": [ { "id": "NP_001095338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095338", "type": "external" } ], "gene_names_uniprotkb": "KIF22", "gene_names_refseq": "KIF22", "protein_names_uniprotkb": "Kinesin-like protein KIF22", "protein_names_refseq": "kinesin-like protein KIF22", "tax_id": 9913, "disease": "", "pathway": " (bta:506294); (R-BTA-2132295); (R-BTA-983189)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0016607 nuclear speck", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0006281 DNA repair;GO:0007018 microtubule-based movement;GO:0007080 mitotic metaphase chromosome alignment;GO:0007062 sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QPL4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPR6-1", "uniprot_id": [ { "id": "RFOX2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPR6", "type": "external" } ], "mass": 41972.0, "length": 394, "protein_name": "RNA binding protein fox-1 homolog 2", "gene_name": "RBFOX2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RBFOX2; FOX2; RBM9", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA binding protein fox-1 homolog 2; Fox-1 homolog B; RNA-binding motif protein 9; RNA-binding protein 9", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity). Together with RNA binding proteins RBPMS and MBNL1/2, activates vascular smooth muscle cells alternative splicing events (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8B8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003714 transcription corepressor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0007399 nervous system development;GO:0045892 negative regulation of DNA-templated transcription;GO:0008380 RNA splicing;GO:0030520 estrogen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QPR6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPT7-1", "uniprot_id": [ { "id": "ERAP2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPT7", "type": "external" } ], "mass": 109719.0, "length": 954, "protein_name": "Endoplasmic reticulum aminopeptidase 2", "gene_name": "ERAP2", "organism": "Bovine", "refseq_name": "endoplasmic reticulum aminopeptidase 2 precursor", "refseq_ac": [ { "id": "NP_001069096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069096", "type": "external" } ], "gene_names_uniprotkb": "ERAP2", "gene_names_refseq": "ERAP2", "protein_names_uniprotkb": "Endoplasmic reticulum aminopeptidase 2; 3.4.11.-", "protein_names_refseq": "endoplasmic reticulum aminopeptidase 2 precursor; leukocyte-derived arginine aminopeptidase", "tax_id": 9913, "disease": "", "pathway": " (bta:513572); (R-BTA-983170)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity;GO:0004177 aminopeptidase activity;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process;GO:0002250 adaptive immune response;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QPT7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQ70-1", "uniprot_id": [ { "id": "MAP1S_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQ70", "type": "external" } ], "mass": 112472.0, "length": 1066, "protein_name": "Microtubule-associated protein 1S", "gene_name": "MAP1S", "organism": "Bovine", "refseq_name": "microtubule-associated protein 1S", "refseq_ac": [ { "id": "NP_001095584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095584", "type": "external" } ], "gene_names_uniprotkb": "MAP1S", "gene_names_refseq": "MAP1S", "protein_names_uniprotkb": "Microtubule-associated protein 1S; MAP-1S", "protein_names_refseq": "MAP-1S; microtubule-associated protein 1S", "tax_id": 9913, "disease": "", "pathway": " (bta:527829)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003779 actin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0005829 cytosol;GO:0005874 microtubule;GO:0030425 dendrite", "go_biological_process": "GO:0007409 axonogenesis;GO:0016358 dendrite development;GO:0006915 apoptotic process;GO:0000226 microtubule cytoskeleton organization;GO:0031114 regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQ70-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQ71-1", "uniprot_id": [ { "id": "FKBP6_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQ71", "type": "external" } ], "mass": 37611.0, "length": 326, "protein_name": "Inactive peptidyl-prolyl cis-trans isomerase FKBP6", "gene_name": "FKBP6", "organism": "Bovine", "refseq_name": "inactive peptidyl-prolyl cis-trans isomerase FKBP6", "refseq_ac": [ { "id": "NP_001095679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095679", "type": "external" } ], "gene_names_uniprotkb": "FKBP6; FKBP36", "gene_names_refseq": "FKBP-6; FKBP6", "protein_names_uniprotkb": "Inactive peptidyl-prolyl cis-trans isomerase FKBP6; 36 kDa FK506-binding protein; FK506-binding protein 6; FKBP-6; Immunophilin FKBP36; Inactive PPIase FKBP6", "protein_names_refseq": "36 kDa FK506-binding protein; FK506 binding protein 6, 36kDa; FK506-binding protein 6; FKBP prolyl isomerase 6; PPIase FKBP6; immunophilin FKBP36; inactive PPIase FKBP6; inactive peptidyl-prolyl cis-trans isomerase FKBP6; peptidyl-prolyl cis-trans isomerase FKBP6; rotamase", "tax_id": 9913, "disease": "", "pathway": " (bta:537921)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27658575", "class_list": "", "function": "Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity)., [UniProtKB]; These results demonstrate for the first time that the FKBP6 promoter is differentially methylated in testes; together with the functional promoter analysis, this suggests that methylation of this promoter may contribute to cattle-yak male infertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006457 protein folding;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QQ71-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQC6-1", "uniprot_id": [ { "id": "HECA2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQC6", "type": "external" } ], "mass": 54561.0, "length": 491, "protein_name": "HEPACAM family member 2", "gene_name": "HEPACAM2", "organism": "Bovine", "refseq_name": "HEPACAM family member 2 precursor", "refseq_ac": [ { "id": "NP_001095444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095444", "type": "external" } ], "gene_names_uniprotkb": "HEPACAM2; MIKI", "gene_names_refseq": "HEPACAM2", "protein_names_uniprotkb": "HEPACAM family member 2; Mitotic kinetics regulator", "protein_names_refseq": "HEPACAM family member 2 precursor; mitotic kinetics regulator", "tax_id": 9913, "disease": "", "pathway": " (bta:513430)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005819 spindle;GO:0030496 midbody", "go_biological_process": "GO:0051301 cell division;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQC6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQL3-1", "uniprot_id": [ { "id": "SEP14_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQL3", "type": "external" } ], "mass": 50146.0, "length": 432, "protein_name": "Septin-14", "gene_name": "SEPTIN14", "organism": "Bovine", "refseq_name": "septin-14", "refseq_ac": [ { "id": "NP_001095557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095557", "type": "external" } ], "gene_names_uniprotkb": "SEPTIN14; SEPT14", "gene_names_refseq": "SEPT14; SEPTIN14; Septin-14", "protein_names_uniprotkb": "Septin-14", "protein_names_refseq": "septin-14", "tax_id": 9913, "disease": "", "pathway": " (bta:524980)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (Probable). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Plays a role in sperm head formation during spermiogenesis, potentially via facilitating localization of ACTN4 to cell filaments (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0001764 neuron migration;GO:0007286 spermatid development;GO:0008104 intracellular protein localization;GO:1905719 protein localization to perinuclear region of cytoplasm;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQL3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQP7-1", "uniprot_id": [ { "id": "DYSF_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQP7", "type": "external" } ], "mass": 239314.0, "length": 2107, "protein_name": "Dysferlin", "gene_name": "DYSF", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DYSF; FER1L1", "gene_names_refseq": "", "protein_names_uniprotkb": "Dysferlin; Dystrophy-associated fer-1-like protein; Fer-1-like protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:508157)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0015630 microtubule cytoskeleton;GO:0031410 cytoplasmic vesicle;GO:0031902 late endosome membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0061025 membrane fusion;GO:0050765 negative regulation of phagocytosis;GO:0033292 T-tubule organization;GO:0006906 vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQP7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQQ9-1", "uniprot_id": [ { "id": "K1C20_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQQ9", "type": "external" } ], "mass": 48172.0, "length": 422, "protein_name": "Keratin, type I cytoskeletal 20", "gene_name": "KRT20", "organism": "Bovine", "refseq_name": "keratin, type I cytoskeletal 20", "refseq_ac": [ { "id": "NP_001095321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095321", "type": "external" } ], "gene_names_uniprotkb": "KRT20", "gene_names_refseq": "KRT20", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 20; CK-20; Cytokeratin-20; K20; Keratin-20", "protein_names_refseq": "CK-20; K20; cytokeratin-20; keratin, type I cytoskeletal 20", "tax_id": 9913, "disease": "", "pathway": " (bta:505214)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0006915 apoptotic process;GO:0050708 regulation of protein secretion;GO:0009267 cellular response to starvation;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQQ9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQT9-1", "uniprot_id": [ { "id": "HACL2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQT9", "type": "external" } ], "mass": 68110.0, "length": 632, "protein_name": "2-hydroxyacyl-CoA lyase 2", "gene_name": "HACL2; ILVBL", "organism": "Bovine", "refseq_name": "2-hydroxyacyl-CoA lyase 2 isoform X2", "refseq_ac": [ { "id": "XP_005208552", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208552", "type": "external" } ], "gene_names_uniprotkb": "HACL2; ILVBL; AHAS; ILVBL", "gene_names_refseq": "ILVBL", "protein_names_uniprotkb": "2-hydroxyacyl-CoA lyase 2; 4.1.2.-; Acetolactate synthase-like protein; IlvB-like protein", "protein_names_refseq": "2-hydroxyacyl-CoA lyase 2 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:506955)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5E9W6", "ec_number_list": [ { "id": "4.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.-", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0016829 lyase activity;GO:0030976 thiamine pyrophosphate binding;GO:0003984 acetolactate synthase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005948 acetolactate synthase complex", "go_biological_process": "GO:0001561 fatty acid alpha-oxidation;GO:0009099 L-valine biosynthetic process;GO:0009097 isoleucine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QQT9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQV6-1", "uniprot_id": [ { "id": "ANM7_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQV6", "type": "external" } ], "mass": 78654.0, "length": 695, "protein_name": "Protein arginine N-methyltransferase 7", "gene_name": "PRMT7", "organism": "Bovine", "refseq_name": "protein arginine N-methyltransferase 7", "refseq_ac": [ { "id": "NP_001095460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095460", "type": "external" } ], "gene_names_uniprotkb": "PRMT7", "gene_names_refseq": "PRMT7", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 7; 2.1.1.321; Histone-arginine N-methyltransferase PRMT7; [Myelin basic protein]-arginine N-methyltransferase PRMT7", "protein_names_refseq": "[Myelin basic protein]-arginine N-methyltransferase PRMT7; histone-arginine N-methyltransferase PRMT7; protein arginine N-methyltransferase 7", "tax_id": 9913, "disease": "", "pathway": " (bta:514202)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.1.1.321", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.321", "type": "external" } ], "go_molecular_function": "GO:0016274 protein-arginine N-methyltransferase activity;GO:0042054 histone methyltransferase activity;GO:0044020 histone H4R3 methyltransferase activity;GO:0035241 protein-arginine omega-N monomethyltransferase activity;GO:0035243 protein-arginine omega-N symmetric methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0018216 peptidyl-arginine methylation;GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQV6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQW8-1", "uniprot_id": [ { "id": "BABA2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQW8", "type": "external" } ], "mass": 43561.0, "length": 383, "protein_name": "BRISC and BRCA1-A complex member 2", "gene_name": "BABAM2", "organism": "Bovine", "refseq_name": "BRISC and BRCA1-A complex member 2", "refseq_ac": [ { "id": "NP_001095744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095744", "type": "external" } ], "gene_names_uniprotkb": "BABAM2; BRE", "gene_names_refseq": "BABAM2; BRE", "protein_names_uniprotkb": "BRISC and BRCA1-A complex member 2; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein", "protein_names_refseq": "BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; BRISC and BRCA1-A complex member 2; Brain and reproductive organ-expressed protein; brain and reproductive organ-expressed (TNFRSF1A modulator)", "tax_id": 9913, "disease": "", "pathway": " (bta:614152); (R-BTA-5689901); (R-BTA-5693565); (R-BTA-5693571); (R-BTA-5693607); (R-BTA-69473)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF signaling through its interactions with TNFRSF1A; however these effects may be indirect., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070552 BRISC complex;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0051301 cell division;GO:0006915 apoptotic process;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQW8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QR20-1", "uniprot_id": [ { "id": "SLF1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QR20", "type": "external" } ], "mass": 121017.0, "length": 1055, "protein_name": "SMC5-SMC6 complex localization factor protein 1", "gene_name": "SLF1", "organism": "Bovine", "refseq_name": "SMC5-SMC6 complex localization factor protein 1", "refseq_ac": [ { "id": "NP_001095528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095528", "type": "external" } ], "gene_names_uniprotkb": "SLF1; ANKRD32; BRCTD1", "gene_names_refseq": "ANKRD32; SLF1", "protein_names_uniprotkb": "SMC5-SMC6 complex localization factor protein 1; Ankyrin repeat domain-containing protein 32; BRCT domain-containing protein 1", "protein_names_refseq": "BRCT domain-containing protein 1; SMC5-SMC6 complex localization factor protein 1; ankyrin repeat domain 32; ankyrin repeat domain-containing protein 32", "tax_id": 9913, "disease": "", "pathway": " (bta:520250)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0035861 site of double-strand break", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0031334 positive regulation of protein-containing complex assembly;GO:2000781 positive regulation of double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QR20-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QR44-1", "uniprot_id": [ { "id": "DGCR8_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QR44", "type": "external" } ], "mass": 84383.0, "length": 760, "protein_name": "Microprocessor complex subunit DGCR8", "gene_name": "DGCR8", "organism": "Bovine", "refseq_name": "microprocessor complex subunit DGCR8", "refseq_ac": [ { "id": "NP_001094674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094674", "type": "external" } ], "gene_names_uniprotkb": "DGCR8", "gene_names_refseq": "DGCR8", "protein_names_uniprotkb": "Microprocessor complex subunit DGCR8; DiGeorge syndrome critical region 8 homolog", "protein_names_refseq": "DiGeorge syndrome critical region 8 homolog; DiGeorge syndrome critical region gene 8; microprocessor complex subunit DGCR8", "tax_id": 9913, "disease": "", "pathway": " (bta:540254)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (By similarity). Involved in the silencing of embryonic stem cell self-renewal. Plays also a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0020037 heme binding;GO:0070878 primary miRNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0016604 nuclear body", "go_biological_process": "GO:0006974 DNA damage response;GO:0031053 primary miRNA processing;GO:2000633 positive regulation of pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QR44-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7E300-1", "uniprot_id": [ { "id": "RHG07_BOVIN", "url": "https://www.uniprot.org/uniprot/A7E300", "type": "external" } ], "mass": 125468.0, "length": 1112, "protein_name": "Rho GTPase-activating protein 7", "gene_name": "DLC1", "organism": "Bovine", "refseq_name": "rho GTPase-activating protein 7", "refseq_ac": [ { "id": "NP_001095963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095963", "type": "external" } ], "gene_names_uniprotkb": "DLC1; ARHGAP7; STARD12", "gene_names_refseq": "DLC-1; DLC1; StARD12", "protein_names_uniprotkb": "Rho GTPase-activating protein 7; DLC-1; Deleted in liver cancer 1 protein homolog; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StAR-related lipid transfer protein 12; StARD12", "protein_names_refseq": "START domain-containing protein 12; deleted in liver cancer 1 protein homolog; rho GTPase-activating protein 7; rho-type GTPase-activating protein 7; stAR-related lipid transfer protein 12", "tax_id": 9913, "disease": "", "pathway": " (bta:511433)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (By similarity). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005925 focal adhesion;GO:0045121 membrane raft", "go_biological_process": "GO:0007165 signal transduction;GO:0030036 actin cytoskeleton organization;GO:0035023 regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7E300-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7E3X2-1", "uniprot_id": [ { "id": "KC1G1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7E3X2", "type": "external" } ], "mass": 52620.0, "length": 457, "protein_name": "Casein kinase I isoform gamma-1", "gene_name": "CSNK1G1", "organism": "Bovine", "refseq_name": "casein kinase I isoform gamma-1", "refseq_ac": [ { "id": "NP_001033235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033235", "type": "external" } ], "gene_names_uniprotkb": "CSNK1G1", "gene_names_refseq": "CSNK1G1", "protein_names_uniprotkb": "Casein kinase I isoform gamma-1; 2.7.11.1; CKI-gamma 1", "protein_names_refseq": "CKI-gamma 1; casein kinase I isoform gamma-1", "tax_id": 9913, "disease": "", "pathway": " (bta:527889)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate. Phosphorylates CLSPN (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32KN4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7E3X2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MAZ3-1", "uniprot_id": [ { "id": "UBA5_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MAZ3", "type": "external" } ], "mass": 44697.0, "length": 404, "protein_name": "Ubiquitin-like modifier-activating enzyme 5", "gene_name": "UBA5", "organism": "Bovine", "refseq_name": "ubiquitin-like modifier-activating enzyme 5", "refseq_ac": [ { "id": "NP_001094537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094537", "type": "external" } ], "gene_names_uniprotkb": "UBA5", "gene_names_refseq": "UBA5", "protein_names_uniprotkb": "Ubiquitin-like modifier-activating enzyme 5; UFM1-activating enzyme; Ubiquitin-activating enzyme 5", "protein_names_refseq": "UFM1-activating enzyme; ubiquitin-activating enzyme 5; ubiquitin-activating enzyme E1 domain-containing protein 1; ubiquitin-like modifier-activating enzyme 5", "tax_id": 9913, "disease": "", "pathway": " (bta:509292); (R-BTA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP. Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding. Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (By similarity). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071566 UFM1 activating enzyme activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0030218 erythrocyte differentiation;GO:0034976 response to endoplasmic reticulum stress;GO:0071569 protein ufmylation;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MAZ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB16-1", "uniprot_id": [ { "id": "EIF3B_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB16", "type": "external" } ], "mass": 88919.0, "length": 786, "protein_name": "Eukaryotic translation initiation factor 3 subunit B", "gene_name": "EIF3B", "organism": "Bovine", "refseq_name": "eukaryotic translation initiation factor 3 subunit B", "refseq_ac": [ { "id": "NP_001095826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095826", "type": "external" } ], "gene_names_uniprotkb": "EIF3B; EIF3S9", "gene_names_refseq": "EIF3B", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit B; Eukaryotic translation initiation factor 3 subunit 9; eIF-3-eta; eIF3b", "protein_names_refseq": "eIF-3-eta; eukaryotic translation initiation factor 3 subunit 9; eukaryotic translation initiation factor 3 subunit B", "tax_id": 9913, "disease": "", "pathway": " (bta:789999); (R-BTA-156827); (R-BTA-72649); (R-BTA-72689); (R-BTA-72695); (R-BTA-72702)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, HAMAP]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0010494 cytoplasmic stress granule;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex", "go_biological_process": "GO:0075522 IRES-dependent viral translational initiation;GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0075525 viral translational termination-reinitiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB16-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBB4-1", "uniprot_id": [ { "id": "M3K13_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MBB4", "type": "external" } ], "mass": 108152.0, "length": 966, "protein_name": "Mitogen-activated protein kinase kinase kinase 13", "gene_name": "MAP3K13", "organism": "Bovine", "refseq_name": "mitogen-activated protein kinase kinase kinase 13", "refseq_ac": [ { "id": "NP_001095323", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095323", "type": "external" } ], "gene_names_uniprotkb": "MAP3K13", "gene_names_refseq": "MAP3K13", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 13; 2.7.11.25", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 13", "tax_id": 9913, "disease": "", "pathway": " (bta:505369)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0004709 MAP kinase kinase kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBB4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBD8-1", "uniprot_id": [ { "id": "SC5AC_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MBD8", "type": "external" } ], "mass": 67410.0, "length": 617, "protein_name": "Sodium-coupled monocarboxylate transporter 2", "gene_name": "SLC5A12", "organism": "Bovine", "refseq_name": "sodium-coupled monocarboxylate transporter 2", "refseq_ac": [ { "id": "NP_001094529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094529", "type": "external" } ], "gene_names_uniprotkb": "SLC5A12; SMCT2", "gene_names_refseq": "SLC5A12", "protein_names_uniprotkb": "Sodium-coupled monocarboxylate transporter 2; Electroneutral sodium monocarboxylate cotransporter; Low-affinity sodium-lactate cotransporter; Solute carrier family 5 member 12", "protein_names_refseq": "electroneutral sodium monocarboxylate cotransporter; low-affinity sodium-lactate cotransporter; sodium-coupled monocarboxylate transporter 2; solute carrier family 5 (sodium/glucose cotransporter), member 12", "tax_id": 9913, "disease": "", "pathway": " (bta:507621); (R-BTA-428643)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an electroneutral and low-affinity sodium Na(+)-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Probably part of D-serine transport systems involved in D-serine reabsorption at the brush border of renal proximal tubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0015129 lactate transmembrane transporter activity;GO:0140161 monocarboxylate:sodium symporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006814 sodium ion transport;GO:0015718 monocarboxylic acid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBD8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBG0-1", "uniprot_id": [ { "id": "PURA2_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MBG0", "type": "external" } ], "mass": 50156.0, "length": 456, "protein_name": "Adenylosuccinate synthetase isozyme 2", "gene_name": "ADSS2", "organism": "Bovine", "refseq_name": "adenylosuccinate synthetase isozyme 2", "refseq_ac": [ { "id": "NP_001161281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161281", "type": "external" } ], "gene_names_uniprotkb": "ADSS2; ADSS", "gene_names_refseq": "ADSS2; ADSS; AMPASE2", "protein_names_uniprotkb": "Adenylosuccinate synthetase isozyme 2; 6.3.4.4; AMPSase 2; AdSS 2; Adenylosuccinate synthetase, acidic isozyme; Adenylosuccinate synthetase, liver isozyme; IMP--aspartate ligase 2; L-type adenylosuccinate synthetase", "protein_names_refseq": "AMPSase 2; IMP--aspartate ligase 2; L-type adenylosuccinate synthetase; adSS 2; adenylosuccinate synthetase isozyme 2; adenylosuccinate synthetase, acidic isozyme; adenylosuccinate synthetase, liver isozyme", "tax_id": 9913, "disease": "", "pathway": " (bta:522529); (R-BTA-73817)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0004019 adenylosuccinate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046040 IMP metabolic process;GO:0044208 'de novo' AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBG0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YWI9-1", "uniprot_id": [ { "id": "TYDP2_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YWI9", "type": "external" } ], "mass": 40826.0, "length": 364, "protein_name": "Tyrosyl-DNA phosphodiesterase 2", "gene_name": "TDP2", "organism": "Bovine", "refseq_name": "tyrosyl-DNA phosphodiesterase 2", "refseq_ac": [ { "id": "NP_001098811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098811", "type": "external" } ], "gene_names_uniprotkb": "TDP2; TTRAP", "gene_names_refseq": "TDP2; TTRAP", "protein_names_uniprotkb": "Tyrosyl-DNA phosphodiesterase 2; 3.1.4.-; 5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor-associated protein; Tyr-DNA phosphodiesterase 2", "protein_names_refseq": "5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor associated protein; tyr-DNA phosphodiesterase 2; tyrosyl-DNA phosphodiesterase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:507579); (R-BTA-5693571)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Also has 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0003697 single-stranded DNA binding;GO:0004518 nuclease activity;GO:0036317 tyrosyl-RNA phosphodiesterase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016605 PML body", "go_biological_process": "GO:0006302 double-strand break repair;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YWI9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YWK3-1", "uniprot_id": [ { "id": "K2C73_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YWK3", "type": "external" } ], "mass": 58836.0, "length": 540, "protein_name": "Keratin, type II cytoskeletal 73", "gene_name": "KRT73", "organism": "Bovine", "refseq_name": "keratin, type II cytoskeletal 73", "refseq_ac": [ { "id": "NP_001104574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104574", "type": "external" } ], "gene_names_uniprotkb": "KRT73", "gene_names_refseq": "KRT73", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 73; CK-73; Cytokeratin-73; K73; Keratin-73; Type II inner root sheath-specific keratin-K6irs3; Type-II keratin Kb36", "protein_names_refseq": "CK-73; K73; cytokeratin-73; keratin 6 irs3; keratin, type II cytoskeletal 73; type II inner root sheath-specific keratin-K6irs3; type-II keratin Kb36", "tax_id": 9913, "disease": "", "pathway": " (bta:531981); (R-BTA-6805567); (R-BTA-6809371)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YWK3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YWM1-1", "uniprot_id": [ { "id": "GGT6_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YWM1", "type": "external" } ], "mass": 49626.0, "length": 490, "protein_name": "Glutathione hydrolase 6", "gene_name": "GGT6; TEKT1", "organism": "Bovine", "refseq_name": "glutathione hydrolase 6", "refseq_ac": [ { "id": "NP_001098904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098904", "type": "external" } ], "gene_names_uniprotkb": "GGT6; TEKT1; TEKT1", "gene_names_refseq": "GGT6", "protein_names_uniprotkb": "Glutathione hydrolase 6; 2.3.2.2; 3.4.19.13; GGT 6; Gamma-glutamyltransferase 6; Gamma-glutamyltranspeptidase 6", "protein_names_refseq": "GGT 6; gamma-glutamyltransferase 6 homolog; gamma-glutamyltranspeptidase 6; glutathione hydrolase 6", "tax_id": 9913, "disease": "", "pathway": " (bta:613919)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors., [UniProtKB, UniProtKB]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.2", "type": "external" }, { "id": "3.4.19.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.13", "type": "external" }, { "id": "3.4.19.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.14", "type": "external" } ], "go_molecular_function": "GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0015630 microtubule cytoskeleton;GO:0005930 axoneme", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YWM1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YY53-1", "uniprot_id": [ { "id": "ADPRM_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YY53", "type": "external" } ], "mass": 39235.0, "length": 337, "protein_name": "Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase", "gene_name": "ADPRM", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ADPRM", "gene_names_refseq": "", "protein_names_uniprotkb": "Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; 3.6.1.16; 3.6.1.53; ADPRibase-Mn; CDP-choline phosphohydrolase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes ADP-ribose, ADP, CDP-glycerol, CDP-choline, CDP-ethanolamine and cyclic ADP-ribose (cADPR), but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.58", "type": "external" }, { "id": "3.6.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.13", "type": "external" }, { "id": "2.7.7.96", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.96", "type": "external" }, { "id": "3.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.16", "type": "external" }, { "id": "3.6.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.53", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.45", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0047631 ADP-ribose diphosphatase activity;GO:0047734 CDP-glycerol diphosphatase activity;GO:0008663 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YY53-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7Z050-1", "uniprot_id": [ { "id": "VIP1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7Z050", "type": "external" } ], "mass": 163665.0, "length": 1477, "protein_name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1", "gene_name": "PPIP5K1", "organism": "Bovine", "refseq_name": "inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1", "refseq_ac": [ { "id": "NP_001098824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098824", "type": "external" } ], "gene_names_uniprotkb": "PPIP5K1; HISPPD2A; VIP1", "gene_names_refseq": "HISPPD2A; PPIP5K1", "protein_names_uniprotkb": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1; 2.7.4.24; Diphosphoinositol pentakisphosphate kinase 1; Histidine acid phosphatase domain-containing protein 2A; InsP6 and PP-IP5 kinase 1", "protein_names_refseq": "histidine acid phosphatase domain containing 2A; histidine acid phosphatase domain-containing protein 2A; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1; insP6 and PP-IP5 kinase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:510684); (R-BTA-1855167)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.24", "type": "external" } ], "go_molecular_function": "GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity;GO:0000828 inositol hexakisphosphate kinase activity;GO:0000832 inositol hexakisphosphate 5-kinase activity;GO:0052723 inositol hexakisphosphate 1-kinase activity;GO:0033857 5-diphosphoinositol pentakisphosphate 1-kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7Z050-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8E657-1", "uniprot_id": [ { "id": "AASS_BOVIN", "url": "https://www.uniprot.org/uniprot/A8E657", "type": "external" } ], "mass": 102084.0, "length": 926, "protein_name": "Alpha-aminoadipic semialdehyde synthase, mitochondrial", "gene_name": "AASS", "organism": "Bovine", "refseq_name": "alpha-aminoadipic semialdehyde synthase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001103267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103267", "type": "external" } ], "gene_names_uniprotkb": "AASS", "gene_names_refseq": "AASS", "protein_names_uniprotkb": "Alpha-aminoadipic semialdehyde synthase, mitochondrial; LKR/SDH", "protein_names_refseq": "LKR/SDH; alpha-aminoadipic semialdehyde synthase, mitochondrial precursor; alpha-aminoadipic semialdehyde synthase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:520865); (R-BTA-71064)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Bifunctional enzyme that catalyzes the first two steps in lysine degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.8", "type": "external" }, { "id": "1.5.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.9", "type": "external" } ], "go_molecular_function": "GO:0004753 saccharopine dehydrogenase activity;GO:0047130 saccharopine dehydrogenase (NADP+, L-lysine-forming) activity;GO:0047131 saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006554 lysine catabolic process;GO:0019878 lysine biosynthetic process via aminoadipic acid;GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8E657-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B8W3-1", "uniprot_id": [ { "id": "ODAD2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B8W3", "type": "external" } ], "mass": 115859.0, "length": 1044, "protein_name": "Outer dynein arm-docking complex subunit 2", "gene_name": "ODAD2", "organism": "Bovine", "refseq_name": "outer dynein arm-docking complex subunit 2", "refseq_ac": [ { "id": "NP_001179560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179560", "type": "external" } ], "gene_names_uniprotkb": "ODAD2; ARMC4", "gene_names_refseq": "ARMC4; ODAD2", "protein_names_uniprotkb": "Outer dynein arm-docking complex subunit 2; Armadillo repeat-containing protein 4", "protein_names_refseq": "armadillo repeat containing 4; armadillo repeat-containing protein 4; outer dynein arm-docking complex subunit 2", "tax_id": 9913, "disease": "", "pathway": " (bta:526515)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19393038;34715025", "class_list": "", "function": "Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0120228 outer dynein arm docking complex", "go_biological_process": "GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E1B8W3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNS6-1", "uniprot_id": [ { "id": "SPAG8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNS6", "type": "external" } ], "mass": 51542.0, "length": 484, "protein_name": "Sperm-associated antigen 8", "gene_name": "SPAG8", "organism": "Bovine", "refseq_name": "sperm-associated antigen 8", "refseq_ac": [ { "id": "NP_001421852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421852", "type": "external" } ], "gene_names_uniprotkb": "SPAG8", "gene_names_refseq": "SPAG8", "protein_names_uniprotkb": "Sperm-associated antigen 8", "protein_names_refseq": "sperm-associated antigen 8", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "19393038;34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0001669 acrosomal vesicle;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030317 flagellated sperm motility;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E1BNS6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8HZJ5-1", "uniprot_id": [ { "id": "RB27B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8HZJ5", "type": "external" } ], "mass": 24612.0, "length": 218, "protein_name": "Ras-related protein Rab-27B", "gene_name": "RAB27B", "organism": "Bovine", "refseq_name": "ras-related protein Rab-27B", "refseq_ac": [ { "id": "NP_777163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777163", "type": "external" } ], "gene_names_uniprotkb": "RAB27B", "gene_names_refseq": "RAB27B", "protein_names_uniprotkb": "Ras-related protein Rab-27B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-27B", "tax_id": 9913, "disease": "", "pathway": " (bta:282858); (R-BTA-114608); (R-BTA-8873719); (R-BTA-8876198)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "14625374", "class_list": "", "function": "Plays a role in regulating the delivery of fusiform vesicles to the apical plasma membrane of umbrella cells of bladder epithelium, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB27B regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes (PubMed:14625374)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0016324 apical plasma membrane;GO:0042470 melanosome;GO:0005770 late endosome", "go_biological_process": "GO:0099641 anterograde axonal protein transport;GO:0006887 exocytosis;GO:0045921 positive regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8HZJ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MIT6-1", "uniprot_id": [ { "id": "ROCK1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8MIT6", "type": "external" } ], "mass": 52386.0, "length": 441, "protein_name": "Rho-associated protein kinase 1", "gene_name": "ROCK1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ROCK1", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho-associated protein kinase 1; 2.7.11.39; ROCK-I; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; p160 ROCK-1; p160ROCK", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "12034773;9099667;9353125", "class_list": "", "function": "Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:9099667, PubMed:9353125). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:9099667, PubMed:9353125). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By similarity). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis (PubMed:12034773). Plays a role in terminal erythroid differentiation (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0072518 Rho-dependent protein serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031267 small GTPase binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0030036 actin cytoskeleton organization;GO:0007266 Rho protein signal transduction;GO:0031032 actomyosin structure organization;GO:0048598 embryonic morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8MIT6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MK44-1", "uniprot_id": [ { "id": "DGAT1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8MK44", "type": "external" } ], "mass": 55602.0, "length": 489, "protein_name": "Diacylglycerol O-acyltransferase 1", "gene_name": "DGAT1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DGAT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Diacylglycerol O-acyltransferase 1; 2.3.1.20; 2.3.1.76; ARAT; Acyl-CoA retinol O-fatty-acyltransferase; Diglyceride acyltransferase; Retinol O-fatty-acyltransferase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:282609)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11827942;12077321;15342525;18704537", "class_list": "", "function": "Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:18704537). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats. In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (By similarity). Also present in female mammary glands, where it produces fat in the milk (PubMed:15342525, PubMed:18704537). May be involved in VLDL (very low density lipoprotein) assembly (By similarity). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (By similarity). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148M3;Q8SQB0", "ec_number_list": [ { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.22", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0050252 retinol O-fatty-acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0019432 triglyceride biosynthetic process;GO:0006640 monoacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8MK44-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9XSG3-1", "uniprot_id": [ { "id": "IDHC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9XSG3", "type": "external" } ], "mass": 46785.0, "length": 414, "protein_name": "Isocitrate dehydrogenase [NADP] cytoplasmic", "gene_name": "IDH1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IDH1; ICDH", "gene_names_refseq": "", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NADP] cytoplasmic; 1.1.1.42; Cytosolic NADP-isocitrate dehydrogenase; IDH1; IDH; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281235)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10358094", "class_list": "", "function": "Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (By similarity). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (By similarity). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (PubMed:10358094)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYV2", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0051287 NAD binding;GO:0004450 isocitrate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process;GO:0006103 2-oxoglutarate metabolic process;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9XSG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1N1R0-1", "uniprot_id": [ { "id": "EFHC2_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1N1R0", "type": "external" } ], "mass": 85454.0, "length": 733, "protein_name": "EF-hand domain-containing family member C2", "gene_name": "EFHC2", "organism": "Bovine", "refseq_name": "EF-hand domain-containing family member C2 isoform X3", "refseq_ac": [ { "id": "XP_059739787", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739787", "type": "external" } ], "gene_names_uniprotkb": "EFHC2", "gene_names_refseq": "EFHC2", "protein_names_uniprotkb": "EF-hand domain-containing family member C2", "protein_names_refseq": "EF-hand domain-containing family member C2 isoform X3", "tax_id": 9913, "disease": "", "pathway": " (bta:100336399)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19393038;34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0048814 regulation of dendrite morphogenesis;GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A3Q1N1R0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N7G5-1", "uniprot_id": [ { "id": "CFA53_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N7G5", "type": "external" } ], "mass": 62015.0, "length": 514, "protein_name": "Cilia- and flagella-associated protein 53", "gene_name": "CFAP53; MBD1", "organism": "Bovine", "refseq_name": "cilia- and flagella-associated protein 53", "refseq_ac": [ { "id": "NP_001291505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291505", "type": "external" } ], "gene_names_uniprotkb": "CFAP53; MBD1; MBD1", "gene_names_refseq": "CCDC11; CFAP53", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 53", "protein_names_refseq": "cilia- and flagella-associated protein 53; coiled-coil domain containing 11; mitogen-activated protein kinase kinase kinase kinase 4-like", "tax_id": 9913, "disease": "", "pathway": " (bta:540193)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:34715025, PubMed:37327785). Regulates motility patterns of both 9+0 and 9+2 motile cilia through differential localization and recruitment of axonemal dynein components (By similarity). Required for centriolar satellite integrity and non-motile cilium assembly (By similarity). Required for motile cilium formation (By similarity). Through its role in beating of primary cilia, involved in the establishment of organ laterality during embryogenesis (PubMed:34715025). Required for sperm flagellum biogenesis and is essential for male fertility (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0036126 sperm flagellum;GO:0002177 manchette;GO:0034451 centriolar satellite;GO:0005879 axonemal microtubule", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0003341 cilium movement;GO:1905198 manchette assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1N7G5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00711-1", "uniprot_id": [ { "id": "LALBA_BOVIN", "url": "https://www.uniprot.org/uniprot/P00711", "type": "external" } ], "mass": 16247.0, "length": 142, "protein_name": "Alpha-lactalbumin", "gene_name": "LALBA", "organism": "Bovine", "refseq_name": "alpha-lactalbumin precursor", "refseq_ac": [ { "id": "NP_776803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776803", "type": "external" } ], "gene_names_uniprotkb": "LALBA; ALACTA", "gene_names_refseq": "LALBA; a-LACTA; alfaLA", "protein_names_uniprotkb": "Alpha-lactalbumin; Lactose synthase B protein", "protein_names_refseq": "alpha lactabumin; alpha lactalbumin; alpha-lactalbumin A; alpha-lactalbumin B; alpha-lactalbumin precursor; lactose synthase B protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281894)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "12170271;16305752;1720415;24065678;24777233;25437004;26000826;2687274;28193539;3120795;34019948;3443304;37604312;5532231;5532232;5534301;6715332;6774718;7263672;8482536;8805552;9250594", "class_list": "", "function": "Data suggest that stabilization of apo-alpha-lactalbumin by mono- and oligo-saccharides can be accounted for by simplified statistical-thermodynamic model considering volume exclusion deriving from steric repulsion between protein and saccharides., [RefSeq, PubMed]; Macromolecular crowding reduces the calcium binding affinity of holo-lactalbumin alpha resulting in the formation of apo-lactalbumin alpha (the calcium-depleted form of holo-LA) leading to aggregate formation. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins., [UniProtKB, UniProtKB, UniProtKB]; These findings suggest that the SNP alpha-LA2516 in the alpha-LA gene likely does not have potential as a molecular marker for milk production traits in Chinese Holstein cows. Publication Status: Online-Only, [RefSeq, PubMed]; This study shows, for the first time, that alpha-lactalbumin isolated in a rare 28kDa dimeric form induces cell death, while 14kDa monomeric alpha-lactalbumin is inactive., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3T111;Q95NE4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0003796 lysozyme activity;GO:0004461 lactose synthase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region;GO:0032991 protein-containing complex", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0032570 response to progesterone;GO:0032355 response to estradiol;GO:1903494 response to dehydroepiandrosterone", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P00711-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25708-1", "uniprot_id": [ { "id": "NDUV1_BOVIN", "url": "https://www.uniprot.org/uniprot/P25708", "type": "external" } ], "mass": 50652.0, "length": 464, "protein_name": "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial", "gene_name": "NDUFV1", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_777233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777233", "type": "external" } ], "gene_names_uniprotkb": "NDUFV1; UQOR1", "gene_names_refseq": "NDUFV1", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; 7.1.1.2; CI-51kD; Complex I-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; NDUFV1", "protein_names_refseq": "CI-51kD; NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NADH dehydrogenase flavoprotein 1; NADH dehydrogenase ubiquinone flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; complex I-51kD", "tax_id": 9913, "disease": "", "pathway": " (bta:287014); (R-BTA-611105); (R-BTA-6799198); (R-BTA-9837999)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10852722;18721790;1900194;2034666;25209663;27509854", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148I2", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051287 NAD binding;GO:0016491 oxidoreductase activity;GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I;GO:0005739 mitochondrion", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P25708-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIQ2-1", "uniprot_id": [ { "id": "MNS1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIQ2", "type": "external" } ], "mass": 60419.0, "length": 495, "protein_name": "Meiosis-specific nuclear structural protein 1", "gene_name": "MNS1", "organism": "Bovine", "refseq_name": "meiosis-specific nuclear structural protein 1", "refseq_ac": [ { "id": "NP_001039803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039803", "type": "external" } ], "gene_names_uniprotkb": "MNS1", "gene_names_refseq": "MNS1", "protein_names_uniprotkb": "Meiosis-specific nuclear structural protein 1", "protein_names_refseq": "meiosis-specific nuclear structural protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:532884)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis (By similarity). Required for sperm flagella assembly (By similarity). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MH18", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0005879 axonemal microtubule", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0051321 meiotic cell cycle;GO:0044782 cilium organization;GO:0007288 sperm axoneme assembly;GO:0045724 positive regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2KIQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA11-1", "uniprot_id": [ { "id": "CF107_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TA11", "type": "external" } ], "mass": 23234.0, "length": 196, "protein_name": "Cilia- and flagella-associated protein 107", "gene_name": "CFAP107", "organism": "Bovine", "refseq_name": "cilia- and flagella-associated protein 107", "refseq_ac": [ { "id": "NP_001033296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033296", "type": "external" } ], "gene_names_uniprotkb": "CFAP107", "gene_names_refseq": "C16H1orf158; C1orf158; CFAP107", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 107", "protein_names_refseq": "chromosome 16 C1orf158 homolog; cilia- and flagella-associated protein 107; protein CFAP107; uncharacterized protein C1orf158 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:615316)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath;GO:0005930 axoneme", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2TA11-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2M2T2-1", "uniprot_id": [ { "id": "TKTI1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2M2T2", "type": "external" } ], "mass": 24500.0, "length": 208, "protein_name": "Tektin bundle-interacting protein 1", "gene_name": "TEKTIP1", "organism": "Bovine", "refseq_name": "tektin bundle-interacting protein 1", "refseq_ac": [ { "id": "NP_001070550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070550", "type": "external" } ], "gene_names_uniprotkb": "TEKTIP1", "gene_names_refseq": "C7H19orf71; TEKTIP1", "protein_names_uniprotkb": "Tektin bundle-interacting protein 1; Uncharacterized protein C19orf71 homolog", "protein_names_refseq": "chromosome 7 C19orf71 homolog; tektin bundle-interacting protein 1; uncharacterized protein C19orf71 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:768023)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34715025", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Located at the center of the tektin bundle where may function to recruit tektins or stabilize the bundle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2M2T2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32L75-1", "uniprot_id": [ { "id": "CP141_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32L75", "type": "external" } ], "mass": 12339.0, "length": 101, "protein_name": "Cilia- and flagella-associated protein 141", "gene_name": "CFAP141", "organism": "Bovine", "refseq_name": "cilia- and flagella-associated protein 141", "refseq_ac": [ { "id": "NP_001033115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033115", "type": "external" } ], "gene_names_uniprotkb": "CFAP141", "gene_names_refseq": "C1orf189; C3H1orf189; CFAP141", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 141", "protein_names_refseq": "chromosome 3 C1orf189 homolog; cilia- and flagella-associated protein 141; protein CFAP141; uncharacterized protein C1orf189 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:504348)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q32L75-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80227-1", "uniprot_id": [ { "id": "ACPH_BOVIN", "url": "https://www.uniprot.org/uniprot/P80227", "type": "external" } ], "mass": 81093.0, "length": 730, "protein_name": "Acylamino-acid-releasing enzyme", "gene_name": "APEH", "organism": "Bovine", "refseq_name": "acylamino-acid-releasing enzyme", "refseq_ac": [ { "id": "NP_001076900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076900", "type": "external" } ], "gene_names_uniprotkb": "APEH", "gene_names_refseq": "AARE; APEH; APH", "protein_names_uniprotkb": "Acylamino-acid-releasing enzyme; 3.4.19.1; AARE; APH; Acyl-peptide hydrolase; Acylaminoacyl-peptidase", "protein_names_refseq": "Acyl-peptide hydrolase; Acylaminoacyl-peptidase; N-acylaminoacyl-peptide hydrolase; acylamino-acid-releasing enzyme", "tax_id": 9913, "disease": "", "pathway": " (bta:514666); (R-BTA-6798695); (R-BTA-72764)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8375399", "class_list": "", "function": "Aminopeptidase involved in the degradation of N(alpha)-acylated peptides. Displays exopeptidase activity toward N-formyl and N-acetyl peptides with a preference for dipeptide substrates (By similarity). Catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:8375399). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Hydrolyzes N-formylated peptides likely arising from N-terminal proteolytic cleavage of bacterial and mitochondrial proteins. May act sequentially with ACY1 in the degradation of N-acylated peptides: APEH first cleaves N-acylaminoacids from N-acylated peptides, then ACY1 further hydrolyzes the N-acylaminoacid into free aminoacid and a carboxylate (By similarity). Displays endopeptidase activity involved in the degradation of oxidized and glycated proteins (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FUX4", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008242 omega peptidase activity;GO:0042802 identical protein binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0050435 amyloid-beta metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P80227-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5L8-1", "uniprot_id": [ { "id": "KBL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5L8", "type": "external" } ], "mass": 45166.0, "length": 419, "protein_name": "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "gene_name": "GCAT", "organism": "Bovine", "refseq_name": "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001068602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068602", "type": "external" } ], "gene_names_uniprotkb": "GCAT; AKBCL", "gene_names_refseq": "GCAT", "protein_names_uniprotkb": "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; 2.3.1.29; AKB ligase; Aminoacetone synthase; Glycine acetyltransferase", "protein_names_refseq": "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; AKB ligase; aminoacetone synthase; aminoacetone synthetase; glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A ligase); glycine acetyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:319141)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10712613;8307963", "class_list": "", "function": "Pyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA. Catalyzes the second reaction step on the main metabolic degradation pathway for L-threonine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9N1E8;Q9T2T7;Q9T2T8", "ec_number_list": [ { "id": "2.3.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.29", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008890 glycine C-acetyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0019518 L-threonine catabolic process to glycine;GO:0006567 L-threonine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0P5L8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5E9Y9-1", "uniprot_id": [ { "id": "NDK7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5E9Y9", "type": "external" } ], "mass": 42599.0, "length": 377, "protein_name": "Nucleoside diphosphate kinase 7", "gene_name": "NME7", "organism": "Bovine", "refseq_name": "nucleoside diphosphate kinase 7", "refseq_ac": [ { "id": "NP_001015656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015656", "type": "external" } ], "gene_names_uniprotkb": "NME7", "gene_names_refseq": "NDK7; NME7; nm23-H7", "protein_names_uniprotkb": "Nucleoside diphosphate kinase 7; 2.7.11.1; 3.1.11.-; NDK7; NDP kinase 7; Putative 3'-5'-DNA exonuclease NDK7; Serine protein kinase NME7", "protein_names_refseq": "3'-5' exonuclease NME7; NDK 7; NDP kinase 7; NDP kinase homolog 7; non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase); nucleoside diphosphate kinase 7; nucleoside diphosphate kinase homolog 7; protein kinase NME7; putative 3'-5'-DNA exonuclease NDK7; serine protein kinase NME7", "tax_id": 9913, "disease": "", "pathway": " (bta:534611); (R-BTA-380270); (R-BTA-380320)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16305752;34715025;37327785", "class_list": "", "function": "Possesses an intrinsic kinase activity. Phosphorylates GSK3B at 'Ser-9', leading to the activation of Wnt/beta-catenin signaling. Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing. In vitro, does not seem to have nucleoside diphosphate kinase activity. Functional component of the gamma-tubulin ring complex, implicated in the regulation of its microtubule-nucleating activity in centrosomes, in a kinase activity-dependent manner. May maintain primary cilium assembly and ciliary microtubule stability. Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, required for motile cilia beating., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005819 spindle;GO:0036126 sperm flagellum;GO:0036064 ciliary basal body", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0006308 DNA catabolic process;GO:0006183 GTP biosynthetic process;GO:0006228 UTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5E9Y9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA24-1", "uniprot_id": [ { "id": "VATO_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TA24", "type": "external" } ], "mass": 21519.0, "length": 205, "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "organism": "Bovine", "refseq_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "refseq_ac": [ { "id": "NP_001033127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033127", "type": "external" } ], "gene_names_uniprotkb": "ATP6V0B", "gene_names_refseq": "ATP6V0B", "protein_names_uniprotkb": "V-type proton ATPase 21 kDa proteolipid subunit c''; V-ATPase 21 kDa proteolipid subunit c''; Vacuolar proton pump 21 kDa proteolipid subunit c''", "protein_names_refseq": "ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b; V-ATPase 21 kDa proteolipid subunit c''; V-ATPase 21 kDa proteolipid subunit; V-type proton ATPase 21 kDa proteolipid subunit c''; V-type proton ATPase 21 kDa proteolipid subunit; vacuolar proton pump 21 kDa proteolipid subunit c''; vacuolar proton pump 21 kDa proteolipid subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:505684); (R-BTA-1222556); (R-BTA-77387); (R-BTA-917977); (R-BTA-9639288); (R-BTA-983712)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32764564", "class_list": "", "function": "Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB]; Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0033179 proton-transporting V-type ATPase, V0 domain", "go_biological_process": "GO:0045851 pH reduction;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2TA24-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23956-1", "uniprot_id": [ { "id": "VATL_BOVIN", "url": "https://www.uniprot.org/uniprot/P23956", "type": "external" } ], "mass": 15720.0, "length": 155, "protein_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "gene_name": "ATP6V0C", "organism": "Bovine", "refseq_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "refseq_ac": [ { "id": "NP_001017954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017954", "type": "external" } ], "gene_names_uniprotkb": "ATP6V0C; ATP6C; ATP6L; LOC101904667", "gene_names_refseq": "ATP6V0C; PLP", "protein_names_uniprotkb": "V-type proton ATPase 16 kDa proteolipid subunit c; V-ATPase 16 kDa proteolipid subunit c; Vacuolar proton pump 16 kDa proteolipid subunit c", "protein_names_refseq": "ATPase, H+ transporting, lysosomal, V0 subunit c; V-ATPase 16 kDa proteolipid subunit c; V-ATPase 16 kDa proteolipid subunit; V-type proton ATPase 16 kDa proteolipid subunit c; V-type proton ATPase 16 kDa proteolipid subunit; proteolipid protein of H+ -ATPase; vacuolar proton pump 16 kDa proteolipid subunit c; vacuolar proton pump 16 kDa proteolipid subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:550622); (R-BTA-1222556); (R-BTA-6798695); (R-BTA-77387); (R-BTA-917977); (R-BTA-9639288); (R-BTA-983712)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "2456571;2527163;32764564", "class_list": "", "function": "Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB, UniProtKB]; Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32764564). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32764564). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZY0", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0016020 membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0030672 synaptic vesicle membrane;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0045851 pH reduction;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P23956-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05443-1", "uniprot_id": [ { "id": "LUM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05443", "type": "external" } ], "mass": 38756.0, "length": 342, "protein_name": "Lumican", "gene_name": "LUM", "organism": "Bovine", "refseq_name": "lumican precursor", "refseq_ac": [ { "id": "NP_776359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776359", "type": "external" } ], "gene_names_uniprotkb": "LUM; LDC", "gene_names_refseq": "LUM", "protein_names_uniprotkb": "Lumican; Corneal keratan sulfate proteoglycan 37B core protein; KSPG; Keratan sulfate proteoglycan", "protein_names_refseq": "KSPG; corneal keratan sulfate proteoglycan 37B core protein; keratan sulfate proteoglycan; lumican precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280847); (R-BTA-2022854); (R-BTA-2022857); (R-BTA-216083)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "14551184;18534835;2139877;8099356", "class_list": "", "function": "These results suggest that lumican plays a pivotal role in the development of tissue engineered cartilage and that regulation of this protein may be important for the production of high-quality implants., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0T2", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005583 fibrillar collagen trimer", "go_biological_process": "GO:0032914 positive regulation of transforming growth factor beta1 production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q05443-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N2K1-1", "uniprot_id": [ { "id": "PCYOX_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N2K1", "type": "external" } ], "mass": 56776.0, "length": 508, "protein_name": "Prenylcysteine oxidase 1", "gene_name": "PCYOX1", "organism": "Bovine", "refseq_name": "prenylcysteine oxidase 1 precursor", "refseq_ac": [ { "id": "NP_001098944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098944", "type": "external" } ], "gene_names_uniprotkb": "PCYOX1", "gene_names_refseq": "PCYOX1", "protein_names_uniprotkb": "Prenylcysteine oxidase 1; 1.8.3.5; Prenylcysteine lyase", "protein_names_refseq": "prenylcysteine lyase; prenylcysteine oxidase 1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:100125835)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10585463;19393038;9287348", "class_list": "", "function": "Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (PubMed:9287348). Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (PubMed:9287348). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (PubMed:9287348)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A6QPR1", "ec_number_list": [ { "id": "1.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.5", "type": "external" } ], "go_molecular_function": "GO:0001735 prenylcysteine oxidase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0030328 prenylcysteine catabolic process;GO:0030327 prenylated protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1N2K1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32L26-1", "uniprot_id": [ { "id": "CLXN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32L26", "type": "external" } ], "mass": 24635.0, "length": 212, "protein_name": "Calaxin", "gene_name": "CLXN", "organism": "Bovine", "refseq_name": "calaxin", "refseq_ac": [ { "id": "NP_001032674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032674", "type": "external" } ], "gene_names_uniprotkb": "CLXN; EFCAB1", "gene_names_refseq": "CLXN; EFCAB1", "protein_names_uniprotkb": "Calaxin; EF-hand calcium-binding domain-containing protein 1", "protein_names_refseq": "EF-hand calcium binding domain 1; EF-hand calcium-binding domain-containing protein 1; calaxin", "tax_id": 9913, "disease": "", "pathway": " (bta:505272)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34715025", "class_list": "", "function": "Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Seems to regulate the assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (PubMed:34715025). Regulates ciliary and flagellar motility and is required for cilia-driven determination of body laterality (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0120228 outer dynein arm docking complex", "go_biological_process": "GO:0009966 regulation of signal transduction;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly;GO:0003352 regulation of cilium movement;GO:1901317 regulation of flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32L26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46563-1", "uniprot_id": [ { "id": "VATH_BOVIN", "url": "https://www.uniprot.org/uniprot/O46563", "type": "external" } ], "mass": 55824.0, "length": 483, "protein_name": "V-type proton ATPase subunit H", "gene_name": "ATP6V1H", "organism": "Bovine", "refseq_name": "V-type proton ATPase subunit H", "refseq_ac": [ { "id": "NP_777129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777129", "type": "external" } ], "gene_names_uniprotkb": "ATP6V1H", "gene_names_refseq": "ATP6V1H; SFD", "protein_names_uniprotkb": "V-type proton ATPase subunit H; V-ATPase 50/57 kDa subunits; V-ATPase subunit H; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD", "protein_names_refseq": "ATPase, H+ transporting, lysosomal, V1 subunit H; V-ATPase 50/57 kDa subunits; V-ATPase subunit H; V-type proton ATPase subunit H; vacuolar proton pump subunit H; vacuolar proton pump subunit SFD", "tax_id": 9913, "disease": "", "pathway": " (bta:282657); (R-BTA-1222556); (R-BTA-77387); (R-BTA-917977); (R-BTA-9639288); (R-BTA-983712)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "32764564;9488725", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A3Q1M3I3;F1MZL6;O46562;Q3ZBD5", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005829 cytosol;GO:0030665 clathrin-coated vesicle membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0006897 endocytosis;GO:0045851 pH reduction;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O46563-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N2N9-1", "uniprot_id": [ { "id": "ODAD1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N2N9", "type": "external" } ], "mass": 77563.0, "length": 687, "protein_name": "Outer dynein arm-docking complex subunit 1", "gene_name": "ODAD1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ODAD1; CCDC114", "gene_names_refseq": "", "protein_names_uniprotkb": "Outer dynein arm-docking complex subunit 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "34715025", "class_list": "", "function": "Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005930 axoneme;GO:0120228 outer dynein arm docking complex", "go_biological_process": "GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1N2N9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MYZ3-1", "uniprot_id": [ { "id": "AFAM_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MYZ3", "type": "external" } ], "mass": 69562.0, "length": 604, "protein_name": "Afamin", "gene_name": "AFM", "organism": "Bovine", "refseq_name": "afamin precursor", "refseq_ac": [ { "id": "NP_001179104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179104", "type": "external" } ], "gene_names_uniprotkb": "AFM", "gene_names_refseq": "AFM", "protein_names_uniprotkb": "Afamin; Alpha-albumin", "protein_names_refseq": "afamin precursor; alpha-albumin", "tax_id": 9913, "disease": "", "pathway": " (bta:508264)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19393038;26902720", "class_list": "", "function": "Functions as a carrier for hydrophobic molecules in body fluids. Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B (PubMed:26902720). Binds vitamin E. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the transport of vitamin E across the blood-brain barrier (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008431 vitamin E binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0071693 protein transport within extracellular region;GO:0031667 response to nutrient levels;GO:0050821 protein stabilization;GO:0051180 vitamin transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3MYZ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00415-1", "uniprot_id": [ { "id": "COX3_BOVIN", "url": "https://www.uniprot.org/uniprot/P00415", "type": "external" } ], "mass": 29933.0, "length": 261, "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "MT-CO3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MT-CO3; COIII; COXIII; MTCO3", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 3; 7.1.1.9; Cytochrome c oxidase polypeptide III", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 9, "publication_id_list": "10089392;10771420;12859984;20385840;26698328;27605664;31533957;7120390;8638158", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q576A5;Q8SE13", "ec_number_list": [ { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" } ], "go_molecular_function": "GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0008535 respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P00415-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21282-1", "uniprot_id": [ { "id": "VATC1_BOVIN", "url": "https://www.uniprot.org/uniprot/P21282", "type": "external" } ], "mass": 43986.0, "length": 382, "protein_name": "V-type proton ATPase subunit C 1", "gene_name": "ATP6V1C1", "organism": "Bovine", "refseq_name": "V-type proton ATPase subunit C 1", "refseq_ac": [ { "id": "NP_788849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788849", "type": "external" } ], "gene_names_uniprotkb": "ATP6V1C1; ATP6C; VATC", "gene_names_refseq": "ATP6V1C1; vatC", "protein_names_uniprotkb": "V-type proton ATPase subunit C 1; V-ATPase subunit C 1; Vacuolar proton pump subunit C 1", "protein_names_refseq": "ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1; V-ATPase subunit C 1; V-type proton ATPase subunit C 1; vacuolar H+ -ATPase C subunit; vacuolar proton pump subunit C 1", "tax_id": 9913, "disease": "", "pathway": " (bta:338089); (R-BTA-1222556); (R-BTA-77387); (R-BTA-917977); (R-BTA-9639288); (R-BTA-983712)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "2147024;32764564", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32764564). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32764564). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VCX0", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0030672 synaptic vesicle membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0045851 pH reduction;GO:0097401 synaptic vesicle lumen acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P21282-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39942-1", "uniprot_id": [ { "id": "VATD_BOVIN", "url": "https://www.uniprot.org/uniprot/P39942", "type": "external" } ], "mass": 28334.0, "length": 247, "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ATP6V1D; ATP6M; VATD", "gene_names_refseq": "", "protein_names_uniprotkb": "V-type proton ATPase subunit D; V-ATPase 28 kDa accessory protein; V-ATPase subunit D; Vacuolar proton pump subunit D", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "32764564;7831318", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32764564). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32764564). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0005813 centrosome;GO:0005929 cilium;GO:0030665 clathrin-coated vesicle membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0060271 cilium assembly;GO:0061512 protein localization to cilium;GO:0045851 pH reduction;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P39942-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63103-1", "uniprot_id": [ { "id": "1433Z_BOVIN", "url": "https://www.uniprot.org/uniprot/P63103", "type": "external" } ], "mass": 27745.0, "length": 245, "protein_name": "14-3-3 protein zeta/delta", "gene_name": "YWHAZ", "organism": "Bovine", "refseq_name": "14-3-3 protein zeta/delta", "refseq_ac": [ { "id": "NP_777239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777239", "type": "external" } ], "gene_names_uniprotkb": "YWHAZ", "gene_names_refseq": "YWHAZ", "protein_names_uniprotkb": "14-3-3 protein zeta/delta; FAS; Factor activating exoenzyme S; KCIP-1; Protein kinase C inhibitor protein 1", "protein_names_refseq": "14-3-3 protein zeta/delta; FAS; KCIP-1; factor activating exoenzyme S; protein kinase C inhibitor protein 1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide", "tax_id": 9913, "disease": "", "pathway": " (bta:287022); (R-BTA-111447); (R-BTA-3769402); (R-BTA-392517); (R-BTA-430116); (R-BTA-450604); (R-BTA-512988); (R-BTA-5625740); (R-BTA-5628897); (R-BTA-75035); (R-BTA-9013700); (R-BTA-9614399)", "pathway_count": 12, "publication_count": 7, "publication_id_list": "12361576;1499718;18550856;7603574;7931346;8460141;9632691", "class_list": "", "function": "Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:7931346). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:7931346). Binding generally results in the modulation of the activity of the binding partner (PubMed:7931346). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Identification of 14-3-3zeta as a novel phosphocofilin binding protein involved in the maintenance of the cellular phosphocofilin pool, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P29213;P29312;Q3ZCF9", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0042470 melanosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0003016 respiratory system process;GO:0006468 protein phosphorylation;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P63103-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28029-1", "uniprot_id": [ { "id": "VATF_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28029", "type": "external" } ], "mass": 13398.0, "length": 119, "protein_name": "V-type proton ATPase subunit F", "gene_name": "ATP6V1F", "organism": "Bovine", "refseq_name": "V-type proton ATPase subunit F", "refseq_ac": [ { "id": "NP_001039334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039334", "type": "external" } ], "gene_names_uniprotkb": "ATP6V1F; ATP6S14; VATF", "gene_names_refseq": "ATP6S14; ATP6V1F", "protein_names_uniprotkb": "V-type proton ATPase subunit F; V-ATPase 14 kDa subunit; V-ATPase subunit F; Vacuolar proton pump subunit F", "protein_names_refseq": "ATPase, vacuolar, 14 kD; V-ATPase 14 kDa subunit; V-ATPase subunit F; V-type proton ATPase subunit F; vacuolar proton pump subunit F", "tax_id": 9913, "disease": "", "pathway": " (bta:282405); (R-BTA-1222556); (R-BTA-77387); (R-BTA-917977); (R-BTA-9639288); (R-BTA-983712)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "32764564;8621738", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32764564). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32764564). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2NKR2", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0016020 membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0030672 synaptic vesicle membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0045851 pH reduction;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28029-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIB5-1", "uniprot_id": [ { "id": "VA0E2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIB5", "type": "external" } ], "mass": 9184.0, "length": 81, "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "ATP6V0E2", "organism": "Bovine", "refseq_name": "V-type proton ATPase subunit e 2", "refseq_ac": [ { "id": "NP_001091043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091043", "type": "external" } ], "gene_names_uniprotkb": "ATP6V0E2", "gene_names_refseq": "ATP6V0E2", "protein_names_uniprotkb": "V-type proton ATPase subunit e 2; V-ATPase subunit e 2; Vacuolar proton pump subunit e 2", "protein_names_refseq": "V-ATPase subunit e 2; V-type proton ATPase subunit e 2; vacuolar proton pump subunit e 2", "tax_id": 9913, "disease": "", "pathway": " (bta:505224)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32764564", "class_list": "", "function": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32764564). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32764564)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0030665 clathrin-coated vesicle membrane;GO:0030672 synaptic vesicle membrane;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain", "go_biological_process": "GO:0045851 pH reduction;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KIB5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32P67-1", "uniprot_id": [ { "id": "PIRC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32P67", "type": "external" } ], "mass": 15654.0, "length": 136, "protein_name": "Piercer of microtubule wall 1 protein", "gene_name": "PIERCE1", "organism": "Bovine", "refseq_name": "piercer of microtubule wall 1 protein", "refseq_ac": [ { "id": "NP_001032568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032568", "type": "external" } ], "gene_names_uniprotkb": "PIERCE1", "gene_names_refseq": "C11H9orf116; PIERCE1", "protein_names_uniprotkb": "Piercer of microtubule wall 1 protein; Pierce1; UPF0691 protein C9orf116 homolog", "protein_names_refseq": "UPF0691 protein C9orf116 homolog; chromosome 11 C9orf116 homolog; piercer of microtubule wall 1 protein", "tax_id": 9913, "disease": "", "pathway": " (bta:618654)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34715025;37327785", "class_list": "", "function": "Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Functions at the initial step of left-right asymmetry specification of the visceral organs., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007368 determination of left/right symmetry;GO:0003341 cilium movement;GO:0035082 axoneme assembly;GO:0061966 establishment of left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q32P67-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LL00-1", "uniprot_id": [ { "id": "A0A3Q1LL00_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LL00", "type": "external" } ], "mass": 57503.0, "length": 508, "protein_name": "unspecific monooxygenase", "gene_name": "CYP2C85", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CYP2C85", "gene_names_refseq": "", "protein_names_uniprotkb": "unspecific monooxygenase; 1.14.14.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:540627); (R-BTA-211981); (R-BTA-211999); (R-BTA-2142670); (R-BTA-2142816); (R-BTA-9027307); (R-BTA-9749641)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0019373 epoxygenase P450 pathway;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q1LL00-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MMV1-1", "uniprot_id": [ { "id": "EFHB_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MMV1", "type": "external" } ], "mass": 97819.0, "length": 877, "protein_name": "EF-hand domain-containing family member B", "gene_name": "EFHB", "organism": "Bovine", "refseq_name": "EF-hand domain-containing family member B", "refseq_ac": [ { "id": "NP_001193537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193537", "type": "external" } ], "gene_names_uniprotkb": "EFHB; CFAP21", "gene_names_refseq": "EFHB", "protein_names_uniprotkb": "EF-hand domain-containing family member B; Cilia- and flagella-associated protein 21", "protein_names_refseq": "EF-hand domain-containing family member B; cilia- and flagella-associated protein 21", "tax_id": 9913, "disease": "", "pathway": " (bta:530549)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19393038;34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:34715025, PubMed:37327785). Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion and the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0070884 regulation of calcineurin-NFAT signaling cascade;GO:0006816 calcium ion transport;GO:0030317 flagellated sperm motility;GO:2001256 regulation of store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1MMV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31800-1", "uniprot_id": [ { "id": "QCR1_BOVIN", "url": "https://www.uniprot.org/uniprot/P31800", "type": "external" } ], "mass": 52736.0, "length": 480, "protein_name": "Cytochrome b-c1 complex subunit 1, mitochondrial", "gene_name": "UQCRC1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "UQCRC1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 1, mitochondrial; Complex III subunit 1; Core protein I; Ubiquinol-cytochrome-c reductase complex core protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:282393)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11073949;12269811;15312779;16024040;16924113;1712295;28100784;2848575;29243944;8592474;9204897;9651245;9694818", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (PubMed:11073949, PubMed:9694818). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0017087 mitochondrial processing peptidase complex", "go_biological_process": "GO:0022904 respiratory electron transport chain;GO:0006627 protein processing involved in protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P31800-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54229-1", "uniprot_id": [ { "id": "CTHL5_BOVIN", "url": "https://www.uniprot.org/uniprot/P54229", "type": "external" } ], "mass": 17616.0, "length": 159, "protein_name": "Cathelicidin-5", "gene_name": "CATHL5", "organism": "Bovine", "refseq_name": "cathelicidin-5 precursor", "refseq_ac": [ { "id": "NP_776935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776935", "type": "external" } ], "gene_names_uniprotkb": "CATHL5; BMAP28", "gene_names_refseq": "CATHL5", "protein_names_uniprotkb": "Cathelicidin-5; Antibacterial peptide BMAP-28; Myeloid antibacterial peptide 28", "protein_names_refseq": "antibacterial peptide BMAP-28; antimicrobial peptide BMAP-28; cathelicidin-5 precursor; myeloid antibacterial peptide 28", "tax_id": 9913, "disease": "", "pathway": " (bta:282167)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19136450;20336731;25729929;8706679;8910461", "class_list": "", "function": "Characterization of single nucleotide polymorphisms (SNPs) and insertion-deletion (indel) polymorphisms within the bovine CATHL gene family., [RefSeq, PubMed]; Data show that L Bmap28 was highly sensitive to proteolysis by proteases., [RefSeq, PubMed]; Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi., [UniProtKB, PubMed]; The combination of the BMAP-28 genotype CC and the MASP-2 genotype GG was the best one, in which the somatic cell score was significantly lower than those in the other combinations. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJ96;B9UKL6", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P54229-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98167-1", "uniprot_id": [ { "id": "SSPO_BOVIN", "url": "https://www.uniprot.org/uniprot/P98167", "type": "external" } ], "mass": 543593.0, "length": 5146, "protein_name": "SCO-spondin", "gene_name": "SSPO", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SSPO", "gene_names_refseq": "", "protein_names_uniprotkb": "SCO-spondin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:282659)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11008217;8743952", "class_list": "", "function": "Involved in the modulation of neuronal aggregation (PubMed:8743952). May be involved in developmental events during the formation of the central nervous system (PubMed:11008217)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 41, "predicted_n_glycosites": 37, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 41, "binding_glycan_count": 0, "secondary_ac_list": "Q8SPM4", "ec_number_list": [], "go_molecular_function": "GO:0030414 peptidase inhibitor activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P98167-1", "record_type": "protein", "filter_code": "0000000.0000101.000100.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46195-1", "uniprot_id": [ { "id": "KGUA_BOVIN", "url": "https://www.uniprot.org/uniprot/P46195", "type": "external" } ], "mass": 21910.0, "length": 198, "protein_name": "Guanylate kinase", "gene_name": "GUK1", "organism": "Bovine", "refseq_name": "guanylate kinase isoform a", "refseq_ac": [ { "id": "NP_001152884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152884", "type": "external" } ], "gene_names_uniprotkb": "GUK1; GUK", "gene_names_refseq": "GUK1", "protein_names_uniprotkb": "Guanylate kinase; 2.7.4.8; GMP kinase", "protein_names_refseq": "GMP kinase; guanylate kinase isoform a", "tax_id": 9913, "disease": "", "pathway": " (bta:281217); (R-BTA-499943); (R-BTA-9748787)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "29515371;7911663;8243671", "class_list": "", "function": "Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:29515371, PubMed:7911663, PubMed:8243671). Involved in the cGMP metabolism in photoreceptors (PubMed:29515371, PubMed:8243671)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCE9", "ec_number_list": [ { "id": "2.7.4.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.8", "type": "external" } ], "go_molecular_function": "GO:0004385 GMP kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0006163 purine nucleotide metabolic process;GO:0006185 dGDP biosynthetic process;GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P46195-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26201-1", "uniprot_id": [ { "id": "CD36_BOVIN", "url": "https://www.uniprot.org/uniprot/P26201", "type": "external" } ], "mass": 52940.0, "length": 472, "protein_name": "Platelet glycoprotein 4", "gene_name": "CD36", "organism": "Bovine", "refseq_name": "platelet glycoprotein 4", "refseq_ac": [ { "id": "NP_001265550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265550", "type": "external" } ], "gene_names_uniprotkb": "CD36; PAS4", "gene_names_refseq": "CD36; GPIIIB; GPIV; PAS-4", "protein_names_uniprotkb": "Platelet glycoprotein 4; GPIIIB; GPIV; Glycoprotein IIIb; PAS IV; PAS-4; Platelet glycoprotein IV", "protein_names_refseq": "CD36 antigen; cluster of differentiation 36; collagen type I receptor, thrombospondin receptor; platelet glycoprotein 4", "tax_id": 9913, "disease": "", "pathway": " (bta:281052); (R-BTA-114608); (R-BTA-1236973); (R-BTA-3000471); (R-BTA-434313); (R-BTA-5686938); (R-BTA-6798695)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "16551677;1697855;1699598;27473969;7682847;8950178;9826197", "class_list": "", "function": "Gammadelta T cells express CD36 and it contributes to responses by these cells to microbial lipoteichoic acid., [RefSeq, PubMed]; Multifunctional glycoprotein that acts as a receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long- and very long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (By similarity). Binds long- and very long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity). Mechanistically, palmitoylated CD36 captures fatty acids on the cell surface, the binding of fatty acids activates downstream kinase LYN, which phosphorylates the palmitoyltransferase ZDHHC5 and inactivates it, resulting in the subsequent depalmitoylation of CD36, a step needed to initiate the endocytic process and delivery of fatty acids into the cell (By similarity). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity). Involved in oral fat perception and preferences (By similarity). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thrombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome. Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results suggest that increased expression of hepatic CD36 and SREBP-1 is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 15, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 64, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "P79111;Q28154;Q3ZBT7", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005041 low-density lipoprotein particle receptor activity;GO:0030169 low-density lipoprotein particle binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0016020 membrane;GO:0045121 membrane raft;GO:0005901 caveola", "go_biological_process": "GO:0007155 cell adhesion;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0031623 receptor internalization;GO:0042953 lipoprotein transport;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 8.1, "record_id": "P26201-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11180-1", "uniprot_id": [ { "id": "ODP2_BOVIN", "url": "https://www.uniprot.org/uniprot/P11180", "type": "external" } ], "mass": 69067.0, "length": 647, "protein_name": "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex", "gene_name": "DLAT", "organism": "Bovine", "refseq_name": "dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex", "refseq_ac": [ { "id": "NP_001192659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192659", "type": "external" } ], "gene_names_uniprotkb": "DLAT", "gene_names_refseq": "DLAT; PDC-E2; PDCE2", "protein_names_uniprotkb": "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; 2.3.1.12; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; PDC-E2; PDCE2; Pyruvate dehydrogenase complex component E2", "protein_names_refseq": "Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex", "tax_id": 9913, "disease": "", "pathway": " (bta:512723)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19393038;20361979;3117054;36414632", "class_list": "", "function": "The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3);. Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F1N690;V6F7T1", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006006 glucose metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P11180-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12234-1", "uniprot_id": [ { "id": "S25A3_BOVIN", "url": "https://www.uniprot.org/uniprot/P12234", "type": "external" } ], "mass": 40140.0, "length": 362, "protein_name": "Solute carrier family 25 member 3", "gene_name": "SLC25A3", "organism": "Bovine", "refseq_name": "solute carrier family 25 member 3 precursor", "refseq_ac": [ { "id": "NP_777082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777082", "type": "external" } ], "gene_names_uniprotkb": "SLC25A3; PHC", "gene_names_refseq": "D1S155E; PiC; SLC25A3", "protein_names_uniprotkb": "Solute carrier family 25 member 3; PTP; Phosphate carrier protein, mitochondrial; Phosphate transport protein; PiC", "protein_names_refseq": "NRAS-related; PTP; phosphate carrier protein, mitochondrial; phosphate carrier), member 3; phosphate transport protein; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 member 3 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:282477)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "2036364;28100784;3038521;4066697;8144629;9712911", "class_list": "", "function": "Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity) (PubMed:9712911). Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (PubMed:9712911). Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (By similarity). May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QQU5", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0015293 symporter activity;GO:0005315 phosphate transmembrane transporter activity;GO:0015317 phosphate:proton symporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0035435 phosphate ion transmembrane transport;GO:1990547 mitochondrial phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P12234-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35816-1", "uniprot_id": [ { "id": "PDP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P35816", "type": "external" } ], "mass": 61184.0, "length": 538, "protein_name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial", "gene_name": "PDP1", "organism": "Bovine", "refseq_name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial", "refseq_ac": [ { "id": "NP_001193282", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193282", "type": "external" } ], "gene_names_uniprotkb": "PDP1; PDP; PPM2C", "gene_names_refseq": "PDP1; PDPc; PDP; PPM2C", "protein_names_uniprotkb": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; 3.1.3.43; PDP 1; PDPC 1; PDPc; Protein phosphatase 2C; Pyruvate dehydrogenase phosphatase catalytic subunit 1", "protein_names_refseq": "PDP 1; PDPC 1; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; protein phosphatase 2C, magnesium-dependent, catalytic subunit; pyruvate dehyrogenase phosphatase catalytic subunit 1", "tax_id": 9913, "disease": "", "pathway": " (bta:280891); (R-BTA-204174)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15554715;32627744;4339797;6288374;8396421;9395502", "class_list": "", "function": "Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" } ], "go_molecular_function": "GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity;GO:0000287 magnesium ion binding;GO:0005509 calcium ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045254 pyruvate dehydrogenase complex;GO:0019910 mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex", "go_biological_process": "GO:0016311 dephosphorylation;GO:0140176 positive regulation of pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35816-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04394-1", "uniprot_id": [ { "id": "NDUV2_BOVIN", "url": "https://www.uniprot.org/uniprot/P04394", "type": "external" } ], "mass": 27308.0, "length": 249, "protein_name": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial", "gene_name": "NDUFV2", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776990", "type": "external" } ], "gene_names_uniprotkb": "NDUFV2", "gene_names_refseq": "NDUFV2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; 7.1.1.2; NADH dehydrogenase subunit II; NADH-ubiquinone oxidoreductase 24 kDa subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; NADH dehydrogenase flavoprotein 2; NADH dehydrogenase subunit II; NADH-ubiquinone oxidoreductase 24 kDa subunit; NADH-ubiquinone reductase 24 kDa mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:282290); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10852722;16150735;18721790;20513438;20599678;2500970;25209663;2598272;27509854;6861757", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790, PubMed:25209663, PubMed:27509854). Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone (PubMed:10852722, PubMed:25209663, PubMed:27509854). Contains one iron-sulfur cluster (PubMed:25209663, PubMed:27509854)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Data show that during NADH-ubiquinone oxidoreductase (Complex I) catalytic electron transfer from NADH to DBQ, the superoxide generation site was mostly shifted to the SQ., [RefSeq, PubMed]; Data suggest that Q(Nf) plays a role in a 'direct' redox-driven proton pump, while Q(Ns) triggers an 'indirect' conformation-driven proton pump in NADH-ubiquinone oxidoreductase (complex I)., [RefSeq, PubMed]; The catalytic function of NDH in the mediation of superoxide generation was investigated by EPR spin-trapping., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0G9", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P04394-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06623-1", "uniprot_id": [ { "id": "CN37_BOVIN", "url": "https://www.uniprot.org/uniprot/P06623", "type": "external" } ], "mass": 44875.0, "length": 400, "protein_name": "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "gene_name": "CNP", "organism": "Bovine", "refseq_name": "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "refseq_ac": [ { "id": "NP_851336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851336", "type": "external" } ], "gene_names_uniprotkb": "CNP", "gene_names_refseq": "CNP", "protein_names_uniprotkb": "2',3'-cyclic-nucleotide 3'-phosphodiesterase; 3.1.4.37; CNPase; CNP; Elastase 2',3'-cyclic-nucleotide 3'-phosphodiesterase", "protein_names_refseq": "2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNPase; elastase 2',3'-cyclic-nucleotide 3'-phosphodiesterase", "tax_id": 9913, "disease": "", "pathway": " (bta:280752)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "2821502;3029107;3036592;6272743", "class_list": "", "function": "Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides (PubMed:6272743). In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZJ6", "ec_number_list": [ { "id": "3.1.4.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.37", "type": "external" } ], "go_molecular_function": "GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016020 membrane;GO:0043209 myelin sheath", "go_biological_process": "GO:0009214 cyclic nucleotide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P06623-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07471-1", "uniprot_id": [ { "id": "CX6A2_BOVIN", "url": "https://www.uniprot.org/uniprot/P07471", "type": "external" } ], "mass": 10800.0, "length": 97, "protein_name": "Cytochrome c oxidase subunit 6A2, mitochondrial", "gene_name": "COX6A2", "organism": "Bovine", "refseq_name": "cytochrome c oxidase subunit 6A2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776947", "type": "external" } ], "gene_names_uniprotkb": "COX6A2; COX6A", "gene_names_refseq": "COX6A2; COXVIAH", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6A2, mitochondrial; COXVIAH; Cytochrome c oxidase polypeptide VIa-heart; Cytochrome c oxidase polypeptide VIb", "protein_names_refseq": "cytochrome c oxidase polypeptide VIa-heart; cytochrome c oxidase polypeptide VIb; cytochrome c oxidase subunit 6A2, mitochondrial precursor; cytochrome c oxidase subunit 6A2, mitochondrial; cytochrome c oxidase subunit VIa polypeptide 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282200); (R-BTA-5628897); (R-BTA-611105); (R-BTA-9707564); (R-BTA-9864848)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10089392;10771420;1647214;20385840;26698328;27605664;28100784;2994692;31533957;7687470;8638158", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in the assembly and stabilization of complex IV (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZ61", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P07471-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C2W5-1", "uniprot_id": [ { "id": "GBRB2_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C2W5", "type": "external" } ], "mass": 54451.0, "length": 472, "protein_name": "Gamma-aminobutyric acid receptor subunit beta-2", "gene_name": "GABRB2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GABRB2", "gene_names_refseq": "", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor subunit beta-2; GABAAR subunit beta-2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "17093081;2548852", "class_list": "", "function": "Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:2548852). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity). Extrasynaptic beta-2 receptors contribute to the tonic GABAergic inhibition (By similarity). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex;GO:0099634 postsynaptic specialization membrane", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0071420 cellular response to histamine;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C2W5-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10063-1", "uniprot_id": [ { "id": "GBRA2_BOVIN", "url": "https://www.uniprot.org/uniprot/P10063", "type": "external" } ], "mass": 51146.0, "length": 451, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-2", "gene_name": "GABRA2", "organism": "Bovine", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-2 precursor", "refseq_ac": [ { "id": "NP_776966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776966", "type": "external" } ], "gene_names_uniprotkb": "GABRA2", "gene_names_refseq": "GABRA2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-2; GABA(A) receptor subunit alpha-2; GABAAR subunit alpha-2", "protein_names_refseq": "GABA(A) receptor subunit alpha-2; GABAAR subunit alpha-2; gamma-aminobutyric acid (GABA) A receptor, alpha 2; gamma-aminobutyric acid receptor subunit alpha-2 precursor; gamma-aminobutyric acid receptor subunit alpha-2; gamma-aminobutyric acid type A receptor alpha2 subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:282236)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2842688", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:2842688). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:2842688). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:2842688). The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P10063-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10938-1", "uniprot_id": [ { "id": "PNMT_BOVIN", "url": "https://www.uniprot.org/uniprot/P10938", "type": "external" } ], "mass": 30918.0, "length": 283, "protein_name": "Phenylethanolamine N-methyltransferase", "gene_name": "PNMT", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PNMT", "gene_names_refseq": "", "protein_names_uniprotkb": "Phenylethanolamine N-methyltransferase; 2.1.1.28; Noradrenaline N-methyltransferase; PNMTase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "13863458;2363805;2874553;3379652;3379653;5412063", "class_list": "", "function": "Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:5412063). Other substrates include phenylethanolamine and octopamine (By similarity). Also methylates normetanephrine (PubMed:13863458, PubMed:5412063)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.28", "type": "external" } ], "go_molecular_function": "GO:0004603 phenylethanolamine N-methyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0032259 methylation;GO:0042418 epinephrine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P10938-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11179-1", "uniprot_id": [ { "id": "ODO2_BOVIN", "url": "https://www.uniprot.org/uniprot/P11179", "type": "external" } ], "mass": 48973.0, "length": 455, "protein_name": "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "gene_name": "DLST", "organism": "Bovine", "refseq_name": "dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "refseq_ac": [ { "id": "NP_001068750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068750", "type": "external" } ], "gene_names_uniprotkb": "DLST", "gene_names_refseq": "DLST", "protein_names_uniprotkb": "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; 2-oxoglutarate dehydrogenase complex component E2; 2.3.1.61; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K; OGDC-E2", "protein_names_refseq": "2-oxoglutarate dehydrogenase complex component E2; E2K; E2; OGDC-E2; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:506888)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1282029;16305752;3115829;36854377", "class_list": "", "function": "Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8L1", "ec_number_list": [ { "id": "2.3.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.61", "type": "external" } ], "go_molecular_function": "GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process;GO:0006104 succinyl-CoA metabolic process;GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P11179-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13183-1", "uniprot_id": [ { "id": "COX7B_BOVIN", "url": "https://www.uniprot.org/uniprot/P13183", "type": "external" } ], "mass": 9065.0, "length": 80, "protein_name": "Cytochrome c oxidase subunit 7B, mitochondrial", "gene_name": "COX7B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COX7B", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7B, mitochondrial; Cytochrome c oxidase polypeptide VIIb; IHQ", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:100300550)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10089392;10771420;20385840;2550462;26698328;27605664;2844245;31533957;8638158", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (PubMed:27605664). Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZ39", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0007417 central nervous system development;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P13183-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21327-1", "uniprot_id": [ { "id": "INPP_BOVIN", "url": "https://www.uniprot.org/uniprot/P21327", "type": "external" } ], "mass": 43965.0, "length": 400, "protein_name": "Inositol polyphosphate 1-phosphatase", "gene_name": "INPP1", "organism": "Bovine", "refseq_name": "inositol polyphosphate 1-phosphatase", "refseq_ac": [ { "id": "NP_776789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776789", "type": "external" } ], "gene_names_uniprotkb": "INPP1", "gene_names_refseq": "INPP1", "protein_names_uniprotkb": "Inositol polyphosphate 1-phosphatase; 3.1.3.57; IPPase; IPP", "protein_names_refseq": "IPPase; IPP; inositol polyphosphate 1-phosphatase", "tax_id": 9913, "disease": "", "pathway": " (bta:281869); (R-BTA-1855183)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "2175905;33172890;7947723;8107142", "class_list": "", "function": "Mg(2+)-dependent phosphatase that catalyzes the hydrolysis of the 1-position phosphate from inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate and participates in inositol phosphate metabolism., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1RMJ2", "ec_number_list": [ { "id": "3.1.3.57", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.57", "type": "external" }, { "id": "3.1.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.7", "type": "external" } ], "go_molecular_function": "GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity;GO:0052829 inositol-1,3,4-trisphosphate 1-phosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P21327-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22292-1", "uniprot_id": [ { "id": "M2OM_BOVIN", "url": "https://www.uniprot.org/uniprot/P22292", "type": "external" } ], "mass": 34172.0, "length": 314, "protein_name": "Mitochondrial 2-oxoglutarate/malate carrier protein", "gene_name": "SLC25A11", "organism": "Bovine", "refseq_name": "mitochondrial 2-oxoglutarate/malate carrier protein", "refseq_ac": [ { "id": "NP_777096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777096", "type": "external" } ], "gene_names_uniprotkb": "SLC25A11; SLC20A4", "gene_names_refseq": "SLC25A11", "protein_names_uniprotkb": "Mitochondrial 2-oxoglutarate/malate carrier protein; Alpha-oxoglutarate carrier; OGCP; SLC25A11; Solute carrier family 25 member 11", "protein_names_refseq": "OGCP; alpha-oxoglutarate carrier; mitochondrial 2-oxoglutarate/malate carrier protein; oxoglutarate carrier), member 11; solute carrier family 25 (mitochondrial carrier", "tax_id": 9913, "disease": "", "pathway": " (bta:282523); (R-BTA-428643); (R-BTA-9856872)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "1457818;14598172;16305752;17442340;18428039;2271695;27479487;3814587;8363582", "class_list": "", "function": "Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate (PubMed:27479487, PubMed:3814587, PubMed:8363582). Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (PubMed:8363582). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). Does not transport glutathione (By similarity). In addition can facilitate proton transport in the presence of protonophores such as long-chain fatty acids, contributing to mitochondrial uncoupling and regulation of mitochondrial energetic efficiency (By similarity). Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, gluconeogenesis from lactate, and nitrogen metabolism (PubMed:14598172). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity). Involved in the regulation of apoptosis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; Linewidth analysis, that is correlated to local probe mobility, indicates a well defined periodicity of the whole segment from G281 to I298, indicating that it has an alpha-helical structure., [RefSeq, PubMed]; Results describe the functional and structural role of amino acid residues in the odd-numbered transmembrane alpha-helices of the bovine mitochondrial oxoglutarate carrier., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJY2;Q5E9W4", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015367 oxoglutarate:malate antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0043490 malate-aspartate shuttle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P22292-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25975-1", "uniprot_id": [ { "id": "CATL1_BOVIN", "url": "https://www.uniprot.org/uniprot/P25975", "type": "external" } ], "mass": 37347.0, "length": 334, "protein_name": "Procathepsin L", "gene_name": "CTSL", "organism": "Bovine", "refseq_name": "cathepsin L2 precursor", "refseq_ac": [ { "id": "NP_776457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776457", "type": "external" } ], "gene_names_uniprotkb": "CTSL; CTSL1", "gene_names_refseq": "CTSL1; CTSL2; CTSL; CTSV", "protein_names_uniprotkb": "Procathepsin L; 3.4.22.15; Cathepsin L1", "protein_names_refseq": "cathepsin L1; cathepsin L2 precursor; cathepsin L2 preproprotein; cathepsin L", "tax_id": 9913, "disease": "", "pathway": " (bta:281108); (R-BTA-1474228); (R-BTA-1592389); (R-BTA-1679131); (R-BTA-2132295); (R-BTA-8939242)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "12869695;1515067;17244622;2044774;21585286", "class_list": "", "function": "Cathepsin L has an previously uncharacterized biological role in the production of [Met]enkephalin, an endogenous peptide neurotransmitter, [RefSeq, PubMed]; Secretory vesicle function of cathepsin L for biosynthesis of active enkephalin opioid peptide contrasts with its function in lysosomes for protein degradation., [RefSeq, PubMed]; The cathepsin L deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease., [RefSeq, PubMed]; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (PubMed:12869695). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (By similarity). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O77502;Q3T0P2", "ec_number_list": [ { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0046872 metal ion binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0016324 apical plasma membrane;GO:0042583 chromaffin granule", "go_biological_process": "GO:0016540 protein autoprocessing;GO:0030574 collagen catabolic process;GO:0051603 proteolysis involved in protein catabolic process;GO:0031638 zymogen activation;GO:0034230 enkephalin processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P25975-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31404-1", "uniprot_id": [ { "id": "VATA_BOVIN", "url": "https://www.uniprot.org/uniprot/P31404", "type": "external" } ], "mass": 68344.0, "length": 617, "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "organism": "Bovine", "refseq_name": "V-type proton ATPase catalytic subunit A", "refseq_ac": [ { "id": "NP_776929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776929", "type": "external" } ], "gene_names_uniprotkb": "ATP6V1A; ATP6A1; ATP6V1A1", "gene_names_refseq": "ATP6A1; ATP6V1A", "protein_names_uniprotkb": "V-type proton ATPase catalytic subunit A; 7.1.2.2; V-ATPase 69 kDa subunit; V-ATPase subunit A; Vacuolar proton pump subunit alpha", "protein_names_refseq": "ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha polypeptide, 70kD; ATPase, H+ transporting, lysosomal V1 subunit A; H(+)-ATPase subunit A; V-ATPase 69 kDa subunit; V-ATPase subunit A; V-type proton ATPase catalytic subunit A; vacuolar H+-ATPase A subunit; vacuolar proton pump subunit alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:282147); (R-BTA-1222556); (R-BTA-77387); (R-BTA-917977); (R-BTA-9639288); (R-BTA-983712)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "12708314;1722207;1835703;30573663;32764564;33741963", "class_list": "", "function": "Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Molecular basis of V-ATPase inhibition by bafilomycin A1. Publication Status: Online-Only, [RefSeq, PubMed]; Preparations of Na+,K(+)-ATPase isozymes from calf brain that contain catalytic subunits of three types (alpha 1, alpha 2, and alpha 3) were obtained.The real isozyme composition of the Na+ pump from the grey matter and the brain stem was determined., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3MHQ8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0030665 clathrin-coated vesicle membrane;GO:0030133 transport vesicle", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0046034 ATP metabolic process;GO:0036295 cellular response to increased oxygen levels;GO:0045851 pH reduction;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P31404-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32007-1", "uniprot_id": [ { "id": "ADT3_BOVIN", "url": "https://www.uniprot.org/uniprot/P32007", "type": "external" } ], "mass": 32877.0, "length": 298, "protein_name": "ADP/ATP translocase 3", "gene_name": "SLC25A6", "organism": "Bovine", "refseq_name": "ADP/ATP translocase 3", "refseq_ac": [ { "id": "NP_777085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777085", "type": "external" } ], "gene_names_uniprotkb": "SLC25A6; AAC3; ANT3", "gene_names_refseq": "ANT3; SLC25A6", "protein_names_uniprotkb": "ADP/ATP translocase 3; ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; ANT 3; Adenine nucleotide translocator 3; Solute carrier family 25 member 6", "protein_names_refseq": "ADP,ATP carrier protein 3; ADP/ATP translocase 3; ANT 2; ANT 3; adenine nucleotide translocator 2; adenine nucleotide translocator 3 (liver); solute carrier family 25, member A6", "tax_id": 9913, "disease": "", "pathway": " (bta:282480); (R-BTA-1268020); (R-BTA-83936); (R-BTA-9837999)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11809823;15595696;16305752;2540808", "class_list": "", "function": "ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (By similarity). It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mapped to the bovine Y chromosome (BTAY) by fluorescence in situ hybridization (FISH) and/or radiation hybrid (RH) mapping., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L5C3;A6QQX7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005471 ATP:ADP antiporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0005757 mitochondrial permeability transition pore complex", "go_biological_process": "GO:0006915 apoptotic process;GO:0046902 regulation of mitochondrial membrane permeability;GO:0140021 mitochondrial ADP transmembrane transport;GO:1990544 mitochondrial ATP transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P32007-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60519-1", "uniprot_id": [ { "id": "GBRL2_BOVIN", "url": "https://www.uniprot.org/uniprot/P60519", "type": "external" } ], "mass": 13667.0, "length": 117, "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 2", "gene_name": "GABARAPL2", "organism": "Bovine", "refseq_name": "gamma-aminobutyric acid receptor-associated protein-like 2", "refseq_ac": [ { "id": "NP_777100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777100", "type": "external" } ], "gene_names_uniprotkb": "GABARAPL2; GEF2", "gene_names_refseq": "GABARAPL2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor-associated protein-like 2; GABA(A) receptor-associated protein-like 2; GATE-16; GEF-2; Ganglioside expression factor 2; General protein transport factor p16; Golgi-associated ATPase enhancer of 16 kDa; MAP1 light chain 3-related protein", "protein_names_refseq": "GABA(A) receptor-associated protein-like 2; GATE-16; GEF-2; MAP1 light chain 3-related protein; gamma-aminobutyric acid receptor-associated protein-like 2; ganglioside expression factor 2; general protein transport factor p16; golgi-associated ATPase enhancer of 16 kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:282531); (R-BTA-1632852); (R-BTA-8854214)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10747018;10856287;12438634;16305752", "class_list": "", "function": "Ubiquitin-like modifier involved in intra-Golgi traffic (PubMed:10747018). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (PubMed:10747018). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (PubMed:10747018). Involved in autophagy (By similarity). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08765;Q3ZC59;Q5E9G2;Q9DCP8;Q9UQF7", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0008429 phosphatidylethanolamine binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0032781 positive regulation of ATP-dependent activity;GO:0070972 protein localization to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P60519-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61420-1", "uniprot_id": [ { "id": "VA0D1_BOVIN", "url": "https://www.uniprot.org/uniprot/P61420", "type": "external" } ], "mass": 40329.0, "length": 351, "protein_name": "V-type proton ATPase subunit d 1", "gene_name": "ATP6V0D1", "organism": "Bovine", "refseq_name": "V-type proton ATPase subunit d 1", "refseq_ac": [ { "id": "NP_776930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776930", "type": "external" } ], "gene_names_uniprotkb": "ATP6V0D1; ATP6D; VPATPD", "gene_names_refseq": "ATP6DV; ATP6D; ATP6V0D1", "protein_names_uniprotkb": "V-type proton ATPase subunit d 1; 32 kDa accessory protein; P39; V-ATPase 40 kDa accessory protein; V-ATPase AC39 subunit; V-ATPase subunit d 1; Vacuolar proton pump subunit d 1", "protein_names_refseq": "32 kDa accessory protein; ATPase, H+ transporting, lysosomal, V0 subunit d1; P39; V-ATPase 40 kDa accessory protein; V-ATPase AC39 subunit; V-ATPase subunit d 1; V-ATPase, subunit D; V-type proton ATPase subunit d 1; vacuolar proton pump subunit d 1; vacuolar proton-ATPase, subunit D", "tax_id": 9913, "disease": "", "pathway": " (bta:282148); (R-BTA-1222556); (R-BTA-77387); (R-BTA-917977); (R-BTA-9639288); (R-BTA-983712)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "2903164;32764564", "class_list": "", "function": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32764564). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32764564). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P12953;Q02547;Q3T0P9", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005769 early endosome;GO:0005765 lysosomal membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain", "go_biological_process": "GO:0007034 vacuolar transport;GO:0006879 intracellular iron ion homeostasis;GO:0060271 cilium assembly;GO:0036295 cellular response to increased oxygen levels;GO:0045851 pH reduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61420-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61585-1", "uniprot_id": [ { "id": "RHOA_BOVIN", "url": "https://www.uniprot.org/uniprot/P61585", "type": "external" } ], "mass": 21768.0, "length": 193, "protein_name": "Transforming protein RhoA", "gene_name": "RHOA", "organism": "Bovine", "refseq_name": "transforming protein RhoA", "refseq_ac": [ { "id": "NP_788818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788818", "type": "external" } ], "gene_names_uniprotkb": "RHOA; ARHA; RHO12", "gene_names_refseq": "ARHA; RHOA", "protein_names_uniprotkb": "Transforming protein RhoA; 3.6.5.2; Gb; p21", "protein_names_refseq": "gb; p21; ras homolog gene family, member A; transforming protein RhoA", "tax_id": 9913, "disease": "", "pathway": " (bta:338049); (R-BTA-114604); (R-BTA-193634); (R-BTA-198203); (R-BTA-209563); (R-BTA-2173791); (R-BTA-392451); (R-BTA-3928662); (R-BTA-3928663); (R-BTA-4086400); (R-BTA-416482); (R-BTA-416550); (R-BTA-416572); (R-BTA-4420097); (R-BTA-5625740); (R-BTA-5625900); (R-BTA-5625970); (R-BTA-5627117); (R-BTA-5663220); (R-BTA-5666185); (R-BTA-5689896); (R-BTA-6785631); (R-BTA-6798695); (R-BTA-8849471); (R-BTA-8980692); (R-BTA-8985586); (R-BTA-9013106)", "pathway_count": 27, "publication_count": 11, "publication_id_list": "1905729;19684203;20610533;20696764;21071747;2174426;23084990;2498316;2506852;25387906;3141419", "class_list": "", "function": "A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa vasorum endothelial cells, is reported., [RefSeq, PubMed]; RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress. Publication Status: Online-Only, [RefSeq, PubMed]; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Involved in the reorientation of endothelial cells and their actin stress fibers in response to cellular mechantransduction-mediated activation by ARHGEF40 (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis. Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center. May be an activator of PLCE1. In neurons, involved in the inhibition of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). When activated by DAAM1 may signal centrosome maturation and chromosomal segregation during cell division. May also be involved in contractile ring formation during cytokinesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The Lbc/alpha-catulin axis participates in 5-HT-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling., [RefSeq, PubMed]; The RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification., [RefSeq, PubMed]; This work provides the first evidence of a global signaling event in response to a localized mechanical stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P06749;Q3ZC72;Q9UEJ4", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0017022 myosin binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005768 endosome;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0043297 apical junction assembly;GO:1990869 cellular response to chemokine;GO:0043931 ossification involved in bone maturation;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P61585-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68530-1", "uniprot_id": [ { "id": "COX2_BOVIN", "url": "https://www.uniprot.org/uniprot/P68530", "type": "external" } ], "mass": 26021.0, "length": 227, "protein_name": "Cytochrome c oxidase subunit 2", "gene_name": "MT-CO2", "organism": "Bovine", "refseq_name": "cytochrome c oxidase subunit II", "refseq_ac": [ { "id": "YP_209208", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_209208", "type": "external" } ], "gene_names_uniprotkb": "MT-CO2; COII; COX2; COXII; MTCO2", "gene_names_refseq": "COX2", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 2; 7.1.1.9; Cytochrome c oxidase polypeptide II", "protein_names_refseq": "cytochrome c oxidase subunit II", "tax_id": 9913, "disease": "", "pathway": " (bta:3283880); (R-BTA-5419276); (R-BTA-5628897); (R-BTA-611105); (R-BTA-9707564); (R-BTA-9864848)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10089392;10771420;20385840;220175;26698328;27605664;28100784;31533957;6265319;7120390;8638158", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P00404", "ec_number_list": [ { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.17.99.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.99.9", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005507 copper ion binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0042773 ATP synthesis coupled electron transport;GO:0017004 cytochrome complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P68530-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79119-1", "uniprot_id": [ { "id": "EPYC_BOVIN", "url": "https://www.uniprot.org/uniprot/P79119", "type": "external" } ], "mass": 36688.0, "length": 321, "protein_name": "Epiphycan", "gene_name": "EPYC", "organism": "Bovine", "refseq_name": "epiphycan precursor", "refseq_ac": [ { "id": "NP_776732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776732", "type": "external" } ], "gene_names_uniprotkb": "EPYC; DSPG3; PGLB", "gene_names_refseq": "DSPG3; EPYC", "protein_names_uniprotkb": "Epiphycan; Dermatan sulfate proteoglycan 3; PG-Lb; Proteoglycan-Lb; Small chondroitin/dermatan sulfate proteoglycan", "protein_names_refseq": "PG-Lb; dermatan sulfate proteoglycan 3; epiphycan precursor; proteoglycan-Lb; small chondroitin/dermatan sulfate proteoglycan", "tax_id": 9913, "disease": "", "pathway": " (bta:281747)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9228042", "class_list": "", "function": "May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0060348 bone development;GO:0061975 articular cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P79119-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79331-1", "uniprot_id": [ { "id": "ATS2_BOVIN", "url": "https://www.uniprot.org/uniprot/P79331", "type": "external" } ], "mass": 133888.0, "length": 1205, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 2", "gene_name": "ADAMTS2", "organism": "Bovine", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 2 precursor", "refseq_ac": [ { "id": "NP_777056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777056", "type": "external" } ], "gene_names_uniprotkb": "ADAMTS2; NPI", "gene_names_refseq": "ADAMTS2", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 2; 3.4.24.14; ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP; Procollagen I N-proteinase; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase; pNPI", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 2 precursor; ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP; a disintegrin and metalloproteinase with thrombospondin motifs 2; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2; pNPI; procollagen I N-proteinase; procollagen I/II amino propeptide-processing enzyme; procollagen N-endopeptidase", "tax_id": 9913, "disease": "", "pathway": " (bta:282401); (R-BTA-1650814); (R-BTA-5173214)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16046392;7622483;9122202", "class_list": "", "function": "Cleaves the propeptides of type I and II collagen prior to fibril assembly (PubMed:7622483). Does not act on type III collagen (PubMed:7622483). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity)., [UniProtKB, UniProtKB, PubMed]; Specific ADAMTS-2 domains cleave the aminopropeptide of fibrillar procollagens types I-III and V, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.221", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.82", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.82", "type": "external" }, { "id": "3.4.24.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.14", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P79331-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28139-1", "uniprot_id": [ { "id": "NCKX1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28139", "type": "external" } ], "mass": 131614.0, "length": 1216, "protein_name": "Sodium/potassium/calcium exchanger 1", "gene_name": "SLC24A1", "organism": "Bovine", "refseq_name": "sodium/potassium/calcium exchanger 1", "refseq_ac": [ { "id": "NP_777080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777080", "type": "external" } ], "gene_names_uniprotkb": "SLC24A1; NCKX1", "gene_names_refseq": "SLC24A1", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 1; Na(+)/K(+)/Ca(2+)-exchange protein 1; Retinal rod Na-Ca+K exchanger; Solute carrier family 24 member 1", "protein_names_refseq": "Na(+)/K(+)/Ca(2+)-exchange protein 1; retinal rod Na-Ca+K exchanger; sodium/potassium/calcium exchanger 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282474); (R-BTA-425561)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10608890;1582405;9478004", "class_list": "", "function": "Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:10608890, PubMed:1582405). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 2, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O46384", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0060292 long-term synaptic depression;GO:0007601 visual perception;GO:0070588 calcium ion transmembrane transport;GO:0060291 long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q28139-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29466-1", "uniprot_id": [ { "id": "VPP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29466", "type": "external" } ], "mass": 96302.0, "length": 838, "protein_name": "V-type proton ATPase 116 kDa subunit a 1", "gene_name": "ATP6V0A1", "organism": "Bovine", "refseq_name": "V-type proton ATPase 116 kDa subunit a 1", "refseq_ac": [ { "id": "NP_777179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777179", "type": "external" } ], "gene_names_uniprotkb": "ATP6V0A1; ATP6N1; VPP1", "gene_names_refseq": "ATP6V0A1", "protein_names_uniprotkb": "V-type proton ATPase 116 kDa subunit a 1; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; V-ATPase 116 kDa subunit a 1; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1", "protein_names_refseq": "ATPase, H+ transporting, lysosomal V0 subunit a1; V-ATPase 116 kDa subunit a 1; V-ATPase 116 kDa subunit a1; V-type proton ATPase 116 kDa subunit a 1; V-type proton ATPase 116 kDa subunit a1; V-type proton ATPase 116 kDa subunit a; clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; vacuolar adenosine triphosphatase subunit Ac116; vacuolar proton pump subunit 1; vacuolar proton translocating ATPase 116 kDa subunit a", "tax_id": 9913, "disease": "", "pathway": " (bta:286768)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "32764564;8006034", "class_list": "", "function": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32764564). V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles. In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (PubMed:32764564). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042470 melanosome;GO:0030665 clathrin-coated vesicle membrane;GO:0030672 synaptic vesicle membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex", "go_biological_process": "GO:0045851 pH reduction;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q29466-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B836-1", "uniprot_id": [ { "id": "ENKUR_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B836", "type": "external" } ], "mass": 30157.0, "length": 259, "protein_name": "Enkurin", "gene_name": "ENKUR", "organism": "Bovine", "refseq_name": "enkurin", "refseq_ac": [ { "id": "NP_001179374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179374", "type": "external" } ], "gene_names_uniprotkb": "ENKUR", "gene_names_refseq": "ENKUR", "protein_names_uniprotkb": "Enkurin", "protein_names_refseq": "enkurin", "tax_id": 9913, "disease": "", "pathway": " (bta:516469)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19393038;34715025;37327785", "class_list": "", "function": "Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:34715025)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece;GO:0005879 axonemal microtubule;GO:0097225 sperm midpiece", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0061966 establishment of left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E1B836-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKF9-1", "uniprot_id": [ { "id": "CFA52_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKF9", "type": "external" } ], "mass": 68637.0, "length": 623, "protein_name": "Cilia- and flagella-associated protein 52", "gene_name": "CFAP52", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CFAP52", "gene_names_refseq": "", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 52", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "19393038;34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (PubMed:34715025). Important for proper ciliary and flagellar beating (PubMed:34715025). May act in cooperation with CFAP45 and axonemal dynein subunit DNAH11. May play a role in cell growth and/or survival (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160112 axonemal B tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E1BKF9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9MZL3-1", "uniprot_id": [ { "id": "CACB3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9MZL3", "type": "external" } ], "mass": 54569.0, "length": 484, "protein_name": "Voltage-dependent L-type calcium channel subunit beta-3", "gene_name": "CACNB3", "organism": "Bovine", "refseq_name": "voltage-dependent L-type calcium channel subunit beta-3", "refseq_ac": [ { "id": "NP_776934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776934", "type": "external" } ], "gene_names_uniprotkb": "CACNB3", "gene_names_refseq": "CACNB3", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit beta-3; CAB3; Calcium channel voltage-dependent subunit beta 3", "protein_names_refseq": "CAB3; calcium channel voltage-dependent subunit beta 3; calcium channel, voltage-dependent, beta 3 subunit; voltage-dependent L-type calcium channel subunit beta-3", "tax_id": 9913, "disease": "", "pathway": " (bta:282160); (R-BTA-112308); (R-BTA-422356)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10684870", "class_list": "", "function": "Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:10684870). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (PubMed:10684870). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08DF1", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0008331 high voltage-gated calcium channel activity;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:1990454 L-type voltage-gated calcium channel complex;GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "GO:0006816 calcium ion transport;GO:0007268 chemical synaptic transmission;GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel;GO:1901843 positive regulation of high voltage-gated calcium channel activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9MZL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RJC2-1", "uniprot_id": [ { "id": "CF161_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RJC2", "type": "external" } ], "mass": 36470.0, "length": 321, "protein_name": "Cilia- and flagella-associated protein 161", "gene_name": "CFAP161", "organism": "Bovine", "refseq_name": "cilia- and flagella-associated protein 161 isoform X1", "refseq_ac": [ { "id": "XP_005221930", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221930", "type": "external" } ], "gene_names_uniprotkb": "CFAP161", "gene_names_refseq": "C21H15orf26; CFAP161", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 161", "protein_names_refseq": "cilia- and flagella-associated protein 161 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "19393038;34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F6RJC2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X6E2-1", "uniprot_id": [ { "id": "CMI2A_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X6E2", "type": "external" } ], "mass": 36204.0, "length": 320, "protein_name": "Ciliary microtubule inner protein 2A", "gene_name": "CIMIP2A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CIMIP2A; FAM166A", "gene_names_refseq": "", "protein_names_uniprotkb": "Ciliary microtubule inner protein 2A", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme (PubMed:37327785). Binds to the intra-tubulin interfaces (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0036064 ciliary basal body;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3X6E2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01096-1", "uniprot_id": [ { "id": "ATIF1_BOVIN", "url": "https://www.uniprot.org/uniprot/P01096", "type": "external" } ], "mass": 12301.0, "length": 109, "protein_name": "ATPase inhibitor, mitochondrial", "gene_name": "ATP5IF1", "organism": "Bovine", "refseq_name": "ATPase inhibitor, mitochondrial precursor", "refseq_ac": [ { "id": "NP_787010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787010", "type": "external" } ], "gene_names_uniprotkb": "ATP5IF1; ATPIF1; ATPI", "gene_names_refseq": "ATP5IF1; ATPIF1", "protein_names_uniprotkb": "ATPase inhibitor, mitochondrial; ATP synthase F1 subunit epsilon; IF(1); IF1; Inhibitor of F(1)F(o)-ATPase", "protein_names_refseq": "ATP synthase F1 subunit epsilon; ATPase inhibitor, mitochondrial precursor; ATPase inhibitor, mitochondrial; ATPase inhibitory factor 1; IF(1); IF1; inhibitor of F(1)F(o)-ATPase", "tax_id": 9913, "disease": "", "pathway": " (bta:327699)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10831597;11327770;11742976;12923572;17895376;18687699;21192948;25049402;2894843;38280428;6461003;7397110", "class_list": "", "function": "Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; In addition to His49, Glu26 participates in pH sensing in bovine IF(1), and the mechanism of pH sensing mediated by Glu26 is different from the dimer-tetramer model proposed previously, [RefSeq, PubMed]; Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme., [UniProtKB, UniProtKB]; The N-terminal region of IF(1) destabilizes the interaction of the inhibitor with F(1)-ATPase and may assist in removing the inhibitor from its binding site when F(1)F(o)-ATPase is making ATP, [RefSeq, PubMed]; The inhibitor protein IF1 from mammalian mitochondria inhibits ATP hydrolysis but not ATP synthesis by the ATP synthase complex., [RefSeq, PubMed]; The intrinsically disordered inhibitory region of IF1 interacts first with the alphaEbetaE-catalytic interface, the most open of the three catalytic interfaces, where the available interactions with the enzyme allow it to form an alpha-helix from residues 31-49., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 24, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2M2T4", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051117 ATPase binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0009986 cell surface;GO:0032991 protein-containing complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0030218 erythrocyte differentiation;GO:0001937 negative regulation of endothelial cell proliferation;GO:0006783 heme biosynthetic process;GO:0051346 negative regulation of hydrolase activity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P01096-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00423-1", "uniprot_id": [ { "id": "COX41_BOVIN", "url": "https://www.uniprot.org/uniprot/P00423", "type": "external" } ], "mass": 19572.0, "length": 169, "protein_name": "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial", "gene_name": "COX4I1", "organism": "Bovine", "refseq_name": "cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001001439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001439", "type": "external" } ], "gene_names_uniprotkb": "COX4I1; COX4", "gene_names_refseq": "COX4I1; COX4", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; COX IV-1; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit IV isoform 1", "protein_names_refseq": "COX IV-1; cytochrome c oxidase polypeptide IV; cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor; cytochrome c oxydase subunit 4", "tax_id": 9913, "disease": "", "pathway": " (bta:281090); (R-BTA-5628897); (R-BTA-611105); (R-BTA-9707564); (R-BTA-9864848)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "10089392;10771420;16305752;19164527;22100820;22172733;22201543;22236806;227779;227780;26698328;27605664;28100784;28695851;31533957;6093095;7557450;8638158", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Structure of bovine cytochrome c oxidase crystallized at a neutral pH has been reported., [RefSeq, PubMed]; Studies indicate that X-ray structure of heart cytochrome c oxidase (CcO) suggest that O(2) molecules are transiently trapped at the Cu(B) site before binding to Fe(a3)(2+) to provide O(2)(-). Review article, [RefSeq, PubMed]; Studies indicate that mutational amino acid replacement in proton channels, at the negative (N) side of membrane-inserted prokaryotic aa(3) oxidases, as well as Zn(2+) binding at this site in the bovine oxidase, uncouples proton pumping. Review article, [RefSeq, PubMed]; Studies indicate that nitric oxide (NO) binding to reduced ba(3) and bovine cytochrome aa3. Review article, [RefSeq, PubMed]; Studies indicate that time-resolved resonance Raman (RR) spectroscopy of whole mitochondria identified a band at 571cm(-1) arising from the oxygenated intermediate at Deltat=0.4, 0.6 and 1.4ms. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZS0;Q5E991", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV;GO:0005829 cytosol", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P00423-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4I9-1", "uniprot_id": [ { "id": "UFL1_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4I9", "type": "external" } ], "mass": 89383.0, "length": 792, "protein_name": "E3 UFM1-protein ligase 1", "gene_name": "UFL1", "organism": "Bovine", "refseq_name": "E3 UFM1-protein ligase 1", "refseq_ac": [ { "id": "NP_001073745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073745", "type": "external" } ], "gene_names_uniprotkb": "UFL1", "gene_names_refseq": "UFL1", "protein_names_uniprotkb": "E3 UFM1-protein ligase 1; 2.3.2.-; E3 UFM1-protein transferase 1", "protein_names_refseq": "E3 UFM1-protein ligase 1; E3 UFM1-protein transferase 1; multiple alpha-helix protein located at ER; regulator of C53/LZAP and DDRGK1", "tax_id": 9913, "disease": "", "pathway": " (bta:515894); (R-BTA-983168)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "30881595;31078114;31721015;32050508;34081293", "class_list": "", "function": "E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (By similarity). Catalyzes ufmylation of many protein, such as CD274/PD-L1, CDK5RAP3, CYB5R3, DDRGK1, EIF6, histone H4, MRE11, P4HB, PDCD1/PD-1, TRIP4, RPN1, RPS20/uS10, RPL10/uL16, RPL26/uL24, SYVN1/HRD1 and TP53/p53 (By similarity). As part of the UREL complex, plays a key role in ribosome recycling by catalyzing mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome (By similarity). Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (By similarity). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (By similarity). Involved in reticulophagy in response to endoplasmic reticulum stress by mediating ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins (By similarity). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (PubMed:30881595). Regulates inflammation in response to endoplasmic reticulum stress by promoting reticulophagy, leading to inhibit the activity of the NF-kappa-B transcription factor (PubMed:30881595, PubMed:31078114, PubMed:31721015, PubMed:32050508). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is, a collateral effect or is required for ufmylation (By similarity). Acts as a negative regulator of T-cell activation by mediating ufmylation and stabilization of PDCD1/PD-1 (By similarity). Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 and ufmylation of MRE11 (By similarity). Mediates ufmylation of TP53/p53, promoting its stability (By similarity). Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (By similarity). Required for hematopoietic stem cell function and hematopoiesis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; These results indicated that UFL1 is a novel endoplasmic reticulum stress-responsive protein in bovine mammary epithelial cells., [RefSeq, PubMed]; UFL1 regulates milk protein and fat synthesis-related gene expression of bovine mammary epithelial cells probably via the mTOR signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0071568 UFM1 transferase activity;GO:0061666 UFM1 ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006281 DNA repair;GO:0060218 hematopoietic stem cell differentiation;GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A1A4I9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MWM0-1", "uniprot_id": [ { "id": "ABCA4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MWM0", "type": "external" } ], "mass": 257376.0, "length": 2281, "protein_name": "Retinal-specific phospholipid-transporting ATPase ABCA4", "gene_name": "ABCA4", "organism": "Bovine", "refseq_name": "retinal-specific phospholipid-transporting ATPase ABCA4", "refseq_ac": [ { "id": "NP_776646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776646", "type": "external" } ], "gene_names_uniprotkb": "ABCA4; ABCR", "gene_names_refseq": "ABCA4; RmP", "protein_names_uniprotkb": "Retinal-specific phospholipid-transporting ATPase ABCA4; 7.6.2.1; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; Retinal-specific ATP-binding cassette transporter; RmP", "protein_names_refseq": "ATP-binding cassette sub-family A member 4; ATP-binding cassette, sub-family A (ABC1), member 4; RIM ABC transporter; RIM protein; retinal-specific ATP-binding cassette transporter; retinal-specific phospholipid-transporting ATPase ABCA4", "tax_id": 9913, "disease": "", "pathway": " (bta:281584); (R-BTA-2453902); (R-BTA-382556)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10075733;10767284;11320094;15471866;19393038;20552428;21721517;22735453;23562398;24549892;24707049;9092582;9202155;9288089", "class_list": "", "function": "ABCA4 can transport N-11-cis-retinylidene-phosphatidylethanolamine (PE), the Schiff-base conjugate of 11-cis-retinal and PE, from the lumen to the cytoplasmic leaflet of disk membranes., [RefSeq, PubMed]; An 18 A-resolution structure of ABCA4 isolated from bovine rod outer segments was determined using electron microscopy and single-particle reconstruction, [RefSeq, PubMed]; Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like the 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where N-cis-retinylidene-phosphatidylethanolamine (N-cis-R-PE) is then isomerized to its all-trans isomer (N-trans-R-PE) and reduced by RDH8 to produce all-trans-retinol (all-trans-rol) and therefore prevents the accumulation of excess of 11-cis-retinal and its schiff-base conjugate and the formation of toxic bisretinoid (PubMed:10075733, PubMed:10767284, PubMed:20552428, PubMed:22735453, PubMed:24707049). Displays both ATPase and GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds (PubMed:10767284). Binds the unprotonated form of N-retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP and ATP binding and hydrolysis induce a protein conformational change that causes the dissociation of N-retinylidene-phosphatidylethanolamine (PubMed:15471866, PubMed:20552428, PubMed:22735453)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Partial dephosphorylation of native bovine ABCA4 led to reduction of both basal and stimulated ATPase activity. Thus, we present the first evidence that phosphorylation of ABCA4 can regulate its function, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 8796, "biomarker_type": "", "glycan_count": 11, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "O02698", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0097381 photoreceptor disc membrane;GO:0001750 photoreceptor outer segment;GO:0120202 rod photoreceptor disc membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0006869 lipid transport;GO:0007601 visual perception;GO:0045332 phospholipid translocation;GO:0042574 retinal metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "F1MWM0-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.010000000000000000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00257-1", "uniprot_id": [ { "id": "ADX_BOVIN", "url": "https://www.uniprot.org/uniprot/P00257", "type": "external" } ], "mass": 19756.0, "length": 186, "protein_name": "Adrenodoxin, mitochondrial", "gene_name": "FDX1", "organism": "Bovine", "refseq_name": "adrenodoxin, mitochondrial precursor", "refseq_ac": [ { "id": "NP_851354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851354", "type": "external" } ], "gene_names_uniprotkb": "FDX1; ADX", "gene_names_refseq": "FDX1", "protein_names_uniprotkb": "Adrenodoxin, mitochondrial; Adrenal ferredoxin; Ferredoxin-1; Hepato-ferredoxin", "protein_names_refseq": "adrenal ferredoxin; adrenodoxin, mitochondrial precursor; adrenodoxin, mitochondrial; hepato-ferredoxin", "tax_id": 9913, "disease": "", "pathway": " (bta:281157); (R-BTA-1362409); (R-BTA-196108); (R-BTA-211976); (R-BTA-2395516); (R-BTA-9857492)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "10620322;11053423;12069587;16305752;1733795;1909889;21526428;2332422;2440863;2454231;25858110;2994043;3011431;3395121;4686920;6766943;9551550", "class_list": "", "function": "Data indicate that the autodisplayed adrenodoxin (Adx) showed reversible redox reactions via direct electron transfer to the mercaptoundecanoic acid (MUA)-modified gold electrode., [RefSeq, PubMed]; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage to produce pregnenolone, the precursor of most steroid hormones. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons., [UniProtKB, PubMed]; Kinetic and optical biosensor study of adrenodoxin mutant AdxS112W displaying an enhanced interaction towards the cholesterol side chain cleavage enzyme (CYP11A1)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D9I2;P08498;P12713;Q32KZ0", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0042446 hormone biosynthetic process;GO:0006694 steroid biosynthetic process;GO:0022900 electron transport chain;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P00257-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02810-1", "uniprot_id": [ { "id": "PI4KB_BOVIN", "url": "https://www.uniprot.org/uniprot/O02810", "type": "external" } ], "mass": 91375.0, "length": 816, "protein_name": "Phosphatidylinositol 4-kinase beta", "gene_name": "PI4KB", "organism": "Bovine", "refseq_name": "phosphatidylinositol 4-kinase beta", "refseq_ac": [ { "id": "NP_777208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777208", "type": "external" } ], "gene_names_uniprotkb": "PI4KB; PIK4CB", "gene_names_refseq": "PI4KB; PIK4CB", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase beta; 2.7.1.67; PI4K-beta; PI4Kbeta; PtdIns 4-kinase beta", "protein_names_refseq": "PI4K-beta; PI4Kbeta; phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, catalytic, beta polypeptide; ptdIns 4-kinase beta", "tax_id": 9913, "disease": "", "pathway": " (bta:286846)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11526106;9218477", "class_list": "", "function": "Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP) (PubMed:11526106, PubMed:9218477). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0071889 14-3-3 protein binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane;GO:0030867 rough endoplasmic reticulum membrane", "go_biological_process": "GO:0048015 phosphatidylinositol-mediated signaling;GO:0048839 inner ear development;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O02810-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46419-1", "uniprot_id": [ { "id": "LIPT_BOVIN", "url": "https://www.uniprot.org/uniprot/O46419", "type": "external" } ], "mass": 42072.0, "length": 373, "protein_name": "Lipoyl amidotransferase LIPT1, mitochondrial", "gene_name": "LIPT1", "organism": "Bovine", "refseq_name": "lipoyl amidotransferase LIPT1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_777220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777220", "type": "external" } ], "gene_names_uniprotkb": "LIPT1", "gene_names_refseq": "LIPT1", "protein_names_uniprotkb": "Lipoyl amidotransferase LIPT1, mitochondrial; 2.3.1.-; 2.3.1.200; Lipoate biosynthesis protein; Lipoate-protein ligase; Lipoyl ligase; Lipoyltransferase 1", "protein_names_refseq": "lipoate biosynthesis protein; lipoate-protein ligase; lipoyl amidotransferase LIPT1, mitochondrial precursor; lipoyl amidotransferase LIPT1, mitochondrial; lipoyl ligase; lipoyltransferase 1, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:286864); (R-BTA-9857492)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17570395;8206978;9405389", "class_list": "", "function": "Lipoyl amidotransferase that catalyzes the transfer of lipoyl moieties from lipoyl-protein H of the glycine cleavage system (lipoyl-GCSH) to E2 subunits of the pyruvate dehydrogenase complex (PDCE2). Unable to catalyze the transfer of octanoyl from octanoyl-GCSH to PDCE2 (By similarity). In vitro, it is also able to catalyze the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes but this reaction may not be physiologically relevant (Probable) (PubMed:8206978)., [UniProtKB, PubMed, UniProtKB, PubMed]; Results describe the crystal structure of bovine lipoyltransferase in complex with lipoyl-AMP., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.61", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.200", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.200", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" } ], "go_molecular_function": "GO:0016410 N-acyltransferase activity;GO:0017118 lipoyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0009249 protein lipoylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O46419-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46606-1", "uniprot_id": [ { "id": "DDHD1_BOVIN", "url": "https://www.uniprot.org/uniprot/O46606", "type": "external" } ], "mass": 97576.0, "length": 875, "protein_name": "Phospholipase DDHD1", "gene_name": "DDHD1", "organism": "Bovine", "refseq_name": "phospholipase DDHD1", "refseq_ac": [ { "id": "NP_788816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788816", "type": "external" } ], "gene_names_uniprotkb": "DDHD1", "gene_names_refseq": "DDHD1", "protein_names_uniprotkb": "Phospholipase DDHD1; 3.1.1.111; 3.1.1.118; 3.1.1.32; DDHD domain-containing protein 1; PA-PLA1; Phosphatidic acid-preferring phospholipase A1; Phospholipid sn-1 acylhydrolase", "protein_names_refseq": "DDHD domain-containing protein 1; PA-PLA1; phosphatidic acid-preferring phospholipase A1; phospholipase DDHD1; phospholipid sn-1 acylhydrolase", "tax_id": 9913, "disease": "", "pathway": " (bta:338047)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10924127;7937808;9488669", "class_list": "", "function": "Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (PubMed:10924127, PubMed:7937808, PubMed:9488669). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (PubMed:10924127, PubMed:7937808). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology. These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (By similarity). May play a regulatory role in spermatogenesis or sperm function (PubMed:7937808)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.19", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004620 phospholipase activity;GO:0008970 phospholipase A1 activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O46606-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77667-1", "uniprot_id": [ { "id": "DHI2_BOVIN", "url": "https://www.uniprot.org/uniprot/O77667", "type": "external" } ], "mass": 43987.0, "length": 404, "protein_name": "11-beta-hydroxysteroid dehydrogenase type 2", "gene_name": "HSD11B2", "organism": "Bovine", "refseq_name": "11-beta-hydroxysteroid dehydrogenase type 2", "refseq_ac": [ { "id": "NP_777067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777067", "type": "external" } ], "gene_names_uniprotkb": "HSD11B2", "gene_names_refseq": "HSD11B2", "protein_names_uniprotkb": "11-beta-hydroxysteroid dehydrogenase type 2; 1.1.1.-; 11-DH2; 11-beta-HSD2; Corticosteroid 11-beta-dehydrogenase isozyme 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase", "protein_names_refseq": "11-DH2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; corticosteroid 11-beta-dehydrogenase isozyme 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282434)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10822012;12773125;17470521;20710123;26519454", "class_list": "", "function": "Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+) (PubMed:10822012, PubMed:17470521, PubMed:26519454). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids (PubMed:10822012). Affinity towards corticosterone is higher than cortisol or dexamethasone (PubMed:10822012). Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure (By similarity). Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen. Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone. Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro. 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as ligand for the G protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity). May protect ovulating oocytes and fertilizing spermatozoa from the adverse effects of cortisol (PubMed:17470521, PubMed:26519454). Catalyzes the conversion of 7-beta-hydroxycholesterol into 7-ketocholesterol (7-oxocholesterol), a precursor of 7-keto,27-hydroxycholesterol, which activates smoothened (SMO) and the smoothened signaling pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Investigation of expression for 11HSD1, 11HSD2, and glucocorticoid receptor during follicular maturation and atresia: in atretic follicles, expression of 11HSD2 increased in both granulosa cells and theca interna layers, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.146", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.146", "type": "external" }, { "id": "1.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.201", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0070523 11-beta-hydroxysteroid dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0008211 glucocorticoid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O77667-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77742-1", "uniprot_id": [ { "id": "OMD_BOVIN", "url": "https://www.uniprot.org/uniprot/O77742", "type": "external" } ], "mass": 49116.0, "length": 422, "protein_name": "Osteomodulin", "gene_name": "OMD", "organism": "Bovine", "refseq_name": "osteomodulin precursor", "refseq_ac": [ { "id": "NP_776372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776372", "type": "external" } ], "gene_names_uniprotkb": "OMD", "gene_names_refseq": "OMD; OSAD", "protein_names_uniprotkb": "Osteomodulin; KSPG osteomodulin; Keratan sulfate proteoglycan osteomodulin; OSAD; Osteoadherin", "protein_names_refseq": "KSPG osteomodulin; keratan sulfate proteoglycan osteomodulin; osteoadherin; osteomodulin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280885)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12648264;19700767;9566981;9642227", "class_list": "", "function": "May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin., [UniProtKB, PubMed]; May play an important role during tooth development and biomineralization of dentin, [RefSeq, PubMed]; Tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O77742-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77783-1", "uniprot_id": [ { "id": "EXT2_BOVIN", "url": "https://www.uniprot.org/uniprot/O77783", "type": "external" } ], "mass": 81887.0, "length": 718, "protein_name": "Exostosin-2", "gene_name": "EXT2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EXT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Exostosin-2; 2.4.1.224; Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; HS-POL; HS-polymerase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10639137;9756849", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors (PubMed:10639137, PubMed:9756849). Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity (By similarity). Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.224", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.224", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0015020 glucuronosyltransferase activity;GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O77783-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q1LFK7-1", "uniprot_id": [ { "id": "PIRC2_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A3Q1LFK7", "type": "external" } ], "mass": 13771.0, "length": 120, "protein_name": "Piercer of microtubule wall 2 protein", "gene_name": "PIERCE2", "organism": "Bovine", "refseq_name": "piercer of microtubule wall 2 protein", "refseq_ac": [ { "id": "XP_059746829", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746829", "type": "external" } ], "gene_names_uniprotkb": "PIERCE2; C10H15orf65; C15orf65", "gene_names_refseq": "PIERCE2", "protein_names_uniprotkb": "Piercer of microtubule wall 2 protein", "protein_names_refseq": "piercer of microtubule wall 2 protein", "tax_id": 9913, "disease": "", "pathway": " (bta:100297185)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34715025;37327785", "class_list": "", "function": "Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007368 determination of left/right symmetry;GO:0003341 cilium movement;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A3Q1LFK7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6B857-1", "uniprot_id": [ { "id": "CFA20_BOVIN", "url": "https://www.uniprot.org/uniprot/Q6B857", "type": "external" } ], "mass": 22748.0, "length": 193, "protein_name": "Cilia- and flagella-associated protein 20", "gene_name": "CFAP20", "organism": "Bovine", "refseq_name": "cilia- and flagella-associated protein 20", "refseq_ac": [ { "id": "NP_001003905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003905", "type": "external" } ], "gene_names_uniprotkb": "CFAP20; GTL3", "gene_names_refseq": "C16orf80; C18H16orf80; CFAP20; GTL3", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 20", "protein_names_refseq": "UPF0468 protein C16orf80 homolog; cilia- and flagella-associated protein 20; gene trap locus 3; transcription factor 2B", "tax_id": 9913, "disease": "", "pathway": " (bta:445424)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15803458;34715025;37327785", "class_list": "", "function": "Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (PubMed:34715025). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005929 cilium;GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0005814 centriole", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:2000253 positive regulation of feeding behavior;GO:2000147 positive regulation of cell motility;GO:0018095 protein polyglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6B857-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9GKN8-1", "uniprot_id": [ { "id": "PRELP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9GKN8", "type": "external" } ], "mass": 43683.0, "length": 381, "protein_name": "Prolargin", "gene_name": "PRELP", "organism": "Bovine", "refseq_name": "prolargin precursor", "refseq_ac": [ { "id": "NP_776859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776859", "type": "external" } ], "gene_names_uniprotkb": "PRELP", "gene_names_refseq": "PRELP", "protein_names_uniprotkb": "Prolargin; Proline-arginine-rich end leucine-rich repeat protein", "protein_names_refseq": "prolargin precursor; prolargin; proline arginine-rich end leucine-rich repeat protein", "tax_id": 9913, "disease": "", "pathway": " (bta:282000)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11007795;11847210", "class_list": "", "function": "May anchor basement membranes to the underlying connective tissue., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9GKN8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9N126-1", "uniprot_id": [ { "id": "RDH8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9N126", "type": "external" } ], "mass": 33956.0, "length": 312, "protein_name": "Retinol dehydrogenase 8", "gene_name": "RDH8", "organism": "Bovine", "refseq_name": "retinol dehydrogenase 8", "refseq_ac": [ { "id": "NP_776592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776592", "type": "external" } ], "gene_names_uniprotkb": "RDH8; PRRDH", "gene_names_refseq": "RDH8", "protein_names_uniprotkb": "Retinol dehydrogenase 8; 1.1.1.300; Photoreceptor outer segment all-trans retinol dehydrogenase", "protein_names_refseq": "photoreceptor outer segment all-trans retinol dehydrogenase; retinol dehydrogenase 8 (all-trans); retinol dehydrogenase 8", "tax_id": 9913, "disease": "", "pathway": " (bta:281449)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10753906", "class_list": "", "function": "Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" } ], "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0042572 retinol metabolic process;GO:0007601 visual perception;GO:0006703 estrogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9N126-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32L77-1", "uniprot_id": [ { "id": "CFA95_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32L77", "type": "external" } ], "mass": 26623.0, "length": 232, "protein_name": "Cilia- and flagella-associated protein 95", "gene_name": "CFAP95", "organism": "Bovine", "refseq_name": "cilia- and flagella-associated protein 95", "refseq_ac": [ { "id": "NP_001073093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073093", "type": "external" } ], "gene_names_uniprotkb": "CFAP95", "gene_names_refseq": "C8H9orf135; C9orf135; CFAP95", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 95", "protein_names_refseq": "chromosome 8 C9orf135 homolog; cilia- and flagella-associated protein 95; protein CFAP95; uncharacterized protein C9orf135 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:616736)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q32L77-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LN4-1", "uniprot_id": [ { "id": "CFA45_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LN4", "type": "external" } ], "mass": 65666.0, "length": 549, "protein_name": "Cilia- and flagella-associated protein 45", "gene_name": "CFAP45", "organism": "Bovine", "refseq_name": "cilia- and flagella-associated protein 45", "refseq_ac": [ { "id": "NP_001033308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033308", "type": "external" } ], "gene_names_uniprotkb": "CFAP45; CCDC19", "gene_names_refseq": "CCDC19; CFAP45", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 45", "protein_names_refseq": "cilia- and flagella-associated protein 45; coiled-coil domain containing 19", "tax_id": 9913, "disease": "", "pathway": " (bta:617350)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19393038;34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:34715025, PubMed:37327785). It is an AMP-binding protein that may facilitate dynein ATPase-dependent ciliary and flagellar beating via adenine nucleotide homeostasis. May function as a donor of AMP to AK8 and hence promote ADP production (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016208 AMP binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece;GO:0005879 axonemal microtubule;GO:0097225 sperm midpiece", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0061966 establishment of left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q32LN4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZT6-1", "uniprot_id": [ { "id": "FLTOP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZT6", "type": "external" } ], "mass": 21185.0, "length": 196, "protein_name": "Protein Flattop", "gene_name": "CFAP126", "organism": "Bovine", "refseq_name": "protein Flattop isoform X1", "refseq_ac": [ { "id": "XP_024843103", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024843103", "type": "external" } ], "gene_names_uniprotkb": "CFAP126; FLTP", "gene_names_refseq": "C3H1orf192; CFAP126; FLTP", "protein_names_uniprotkb": "Protein Flattop; Cilia- and flagella-associated protein 126", "protein_names_refseq": "protein Flattop isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "34715025", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (PubMed:34715025). Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0016324 apical plasma membrane;GO:0036126 sperm flagellum;GO:0036064 ciliary basal body;GO:0005879 axonemal microtubule", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SZT6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA38-1", "uniprot_id": [ { "id": "TEKT4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TA38", "type": "external" } ], "mass": 51945.0, "length": 447, "protein_name": "Tektin-4", "gene_name": "TEKT4", "organism": "Bovine", "refseq_name": "tektin-4", "refseq_ac": [ { "id": "NP_001033158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033158", "type": "external" } ], "gene_names_uniprotkb": "TEKT4", "gene_names_refseq": "TEKT4", "protein_names_uniprotkb": "Tektin-4", "protein_names_refseq": "tektin-4", "tax_id": 9913, "disease": "", "pathway": " (bta:510343)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22444558;34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (PubMed:34715025). Contributes to normal sperm motility (By similarity)., [UniProtKB, PubMed, UniProtKB]; This study demonstrates that the expression patterns of tektin-4 were a proxy for an effect on spermatozoa motility and consequently bull infertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece;GO:0005879 axonemal microtubule;GO:0097225 sperm midpiece", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2TA38-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBR5-1", "uniprot_id": [ { "id": "CMI2B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBR5", "type": "external" } ], "mass": 30514.0, "length": 274, "protein_name": "Ciliary microtubule inner protein 2B", "gene_name": "CIMIP2B", "organism": "Bovine", "refseq_name": "ciliary microtubule inner protein 2B", "refseq_ac": [ { "id": "NP_001033602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033602", "type": "external" } ], "gene_names_uniprotkb": "CIMIP2B; FAM166B", "gene_names_refseq": "CIMIP2B; FAM166B", "protein_names_uniprotkb": "Ciliary microtubule inner protein 2B", "protein_names_refseq": "ciliary microtubule inner protein 2B; protein FAM166B", "tax_id": 9913, "disease": "", "pathway": " (bta:507810)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34715025", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005879 axonemal microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2TBR5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32KZ9-1", "uniprot_id": [ { "id": "TEKT1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32KZ9", "type": "external" } ], "mass": 48719.0, "length": 418, "protein_name": "Tektin-1", "gene_name": "TEKT1", "organism": "Bovine", "refseq_name": "tektin-1", "refseq_ac": [ { "id": "NP_001069251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069251", "type": "external" } ], "gene_names_uniprotkb": "TEKT1", "gene_names_refseq": "TEKT1", "protein_names_uniprotkb": "Tektin-1", "protein_names_refseq": "tektin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:519068)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24521320;34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme (PubMed:34715025, PubMed:37327785). Forms filamentous polymers in the walls of ciliary and flagellar microtubules (PubMed:34715025)., [UniProtKB, PubMed, PubMed]; These observations suggest another potential role for TEKT1 as a cytoskeletal element in the sperm head, or as a molecule involved in acrosome-related phenomena, such as acrosome reaction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q32KZ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LJ7-1", "uniprot_id": [ { "id": "RIBC2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LJ7", "type": "external" } ], "mass": 44695.0, "length": 377, "protein_name": "RIB43A-like with coiled-coils protein 2", "gene_name": "RIBC2", "organism": "Bovine", "refseq_name": "RIB43A-like with coiled-coils protein 2", "refseq_ac": [ { "id": "NP_001033280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033280", "type": "external" } ], "gene_names_uniprotkb": "RIBC2", "gene_names_refseq": "RIBC2", "protein_names_uniprotkb": "RIB43A-like with coiled-coils protein 2", "protein_names_refseq": "RIB43A-like with coiled-coils protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:540723)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19393038;34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G1K180", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q32LJ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SQ28-1", "uniprot_id": [ { "id": "SAA3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8SQ28", "type": "external" } ], "mass": 14724.0, "length": 131, "protein_name": "Serum amyloid A-3 protein", "gene_name": "SAA3", "organism": "Bovine", "refseq_name": "mammary serum amyloid A3.2 precursor", "refseq_ac": [ { "id": "NP_001229502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229502", "type": "external" } ], "gene_names_uniprotkb": "SAA3", "gene_names_refseq": "M-SAA3.2; SAA3", "protein_names_uniprotkb": "Serum amyloid A-3 protein", "protein_names_refseq": "mammary serum amyloid A3.2 precursor; serum amyloid A3 protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281474); (bta:618238)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11048944;11730930;16837143;19283521", "class_list": "", "function": "Major acute phase reactant. Apolipoprotein of the HDL complex (By similarity). May have a role in protection of the mammary gland during remodeling and infection (Probable). In vitro exhibits antimicrobial activity against Escherichia coli, Streptococcus uberis and Pseudomonas aeruginosa (PubMed:19283521)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A023VWT2;Q32PB7;Q56J78;Q9MZT5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8SQ28-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9I5-1", "uniprot_id": [ { "id": "CF276_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9I5", "type": "external" } ], "mass": 19358.0, "length": 170, "protein_name": "Cilia- and flagella-associated protein 276", "gene_name": "CFAP276", "organism": "Bovine", "refseq_name": "cilia- and flagella-associated protein 276 isoform X1", "refseq_ac": [ { "id": "XP_002686201", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686201", "type": "external" } ], "gene_names_uniprotkb": "CFAP276; C3H1orf194", "gene_names_refseq": "CFAP276", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 276", "protein_names_refseq": "cilia- and flagella-associated protein 276 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:613530)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19393038;34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:34715025, PubMed:37327785). May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160112 axonemal B tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E1B9I5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJL9-1", "uniprot_id": [ { "id": "CF210_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJL9", "type": "external" } ], "mass": 65300.0, "length": 547, "protein_name": "Cilia- and flagella- associated protein 210", "gene_name": "CFAP210", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CFAP210; CCDC173", "gene_names_refseq": "", "protein_names_uniprotkb": "Cilia- and flagella- associated protein 210", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "19393038;34715025;37327785", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160112 axonemal B tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E1BJL9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MIM4-1", "uniprot_id": [ { "id": "F1MIM4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MIM4", "type": "external" } ], "mass": 67021.0, "length": 615, "protein_name": "Carboxylic ester hydrolase", "gene_name": "ACHE", "organism": "Bovine", "refseq_name": "acetylcholinesterase isoform X4", "refseq_ac": [ { "id": "XP_005225251", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225251", "type": "external" } ], "gene_names_uniprotkb": "ACHE", "gene_names_refseq": "ACHE", "protein_names_uniprotkb": "Carboxylic ester hydrolase; 3.1.1.-", "protein_names_refseq": "acetylcholinesterase isoform X4", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004104 cholinesterase activity;GO:0042166 acetylcholine binding;GO:0042803 protein homodimerization activity;GO:0005518 collagen binding;GO:0043236 laminin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0005615 extracellular space;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0019695 choline metabolic process;GO:0007155 cell adhesion;GO:0002076 osteoblast development;GO:0006581 acetylcholine catabolic process;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MIM4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95JC7-1", "uniprot_id": [ { "id": "AAAT_BOVIN", "url": "https://www.uniprot.org/uniprot/Q95JC7", "type": "external" } ], "mass": 56448.0, "length": 539, "protein_name": "Neutral amino acid transporter B(0)", "gene_name": "SLC1A5", "organism": "Bovine", "refseq_name": "neutral amino acid transporter B(0)", "refseq_ac": [ { "id": "NP_777026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777026", "type": "external" } ], "gene_names_uniprotkb": "SLC1A5; ASCT2", "gene_names_refseq": "ASCT2; SLC1A5", "protein_names_uniprotkb": "Neutral amino acid transporter B(0); ATB(0); Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5", "protein_names_refseq": "ATB(0); neutral amino acid transporter B(0); sodium-dependent neutral amino acid transporter type 2; solute carrier family 1 (neutral amino acid transporter), member 5", "tax_id": 9913, "disease": "", "pathway": " (bta:282355); (R-BTA-352230); (R-BTA-9013406); (R-BTA-9013407); (R-BTA-9013423)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "11997120;31597423", "class_list": "", "function": "ASCT2 Is Involved in SARS-Mediated beta-Casein Synthesis of Bovine Mammary Epithelial Cells with Methionine Supply., [RefSeq, PubMed]; Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (By similarity) (PubMed:11997120). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (By similarity). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (By similarity). Part of transport systems for D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons. May contribute to D-serine reabsorption at the brush border of renal proximal tubules thus modulating the dynamics of urinary versus blood D-serine levels (By similarity). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q08DD9", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0015293 symporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0042470 melanosome", "go_biological_process": "GO:0030218 erythrocyte differentiation;GO:0006868 glutamine transport;GO:0070207 protein homotrimerization;GO:0140009 L-aspartate import across plasma membrane;GO:1902475 L-alpha-amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q95JC7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BDM8-1", "uniprot_id": [ { "id": "E1BDM8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BDM8", "type": "external" } ], "mass": 54377.0, "length": 483, "protein_name": "Probable ATP-dependent RNA helicase DDX6", "gene_name": "DDX6", "organism": "Bovine", "refseq_name": "probable ATP-dependent RNA helicase DDX6", "refseq_ac": [ { "id": "NP_001137339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137339", "type": "external" } ], "gene_names_uniprotkb": "DDX6", "gene_names_refseq": "DDX6", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX6; 3.6.4.13; DEAD box protein 6; Probable ATP-dependent RNA helicase ddx6", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box helicase 6; DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; probable ATP-dependent RNA helicase DDX6", "tax_id": 9913, "disease": "", "pathway": " (bta:513906); (R-BTA-430039)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "28842848", "class_list": "", "function": "DDX6 is a negative regulatory factor that negatively regulates milk synthesis and cell proliferation via inhibiting the mTOR, SREBP-1c, and cyclin D1 pathways., [RefSeq, PubMed]; Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity;GO:0003729 mRNA binding", "go_cellular_component": "GO:0000932 P-body;GO:0005634 nucleus;GO:0005829 cytosol;GO:0016442 RISC complex;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0019074 viral RNA genome packaging;GO:0017148 negative regulation of translation;GO:0033962 P-body assembly;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BDM8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MLH9-1", "uniprot_id": [ { "id": "F1MLH9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MLH9", "type": "external" } ], "mass": 48763.0, "length": 457, "protein_name": "Paired box protein Pax-8", "gene_name": "PAX8", "organism": "Bovine", "refseq_name": "paired box protein Pax-8 isoform X2", "refseq_ac": [ { "id": "XP_002691446", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691446", "type": "external" } ], "gene_names_uniprotkb": "PAX8", "gene_names_refseq": "PAX8", "protein_names_uniprotkb": "Paired box protein Pax-8", "protein_names_refseq": "paired box protein Pax-8 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:534661)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation;GO:0039003 pronephric field specification;GO:0072289 metanephric nephron tubule formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MLH9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BH71-1", "uniprot_id": [ { "id": "E1BH71_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BH71", "type": "external" } ], "mass": 83430.0, "length": 739, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "DTX3L", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase DTX3L", "refseq_ac": [ { "id": "NP_001179325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179325", "type": "external" } ], "gene_names_uniprotkb": "DTX3L", "gene_names_refseq": "DTX3L", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase DTX3L; deltex 3-like", "tax_id": 9913, "disease": "", "pathway": " (bta:515051); (R-BTA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0097677 STAT family protein binding;GO:0004857 enzyme inhibitor activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0016567 protein ubiquitination;GO:1902966 positive regulation of protein localization to early endosome;GO:2000646 positive regulation of receptor catabolic process;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BH71-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5E9X2-1", "uniprot_id": [ { "id": "MP2K6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5E9X2", "type": "external" } ], "mass": 37578.0, "length": 334, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 6", "gene_name": "MAP2K6", "organism": "Bovine", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 6", "refseq_ac": [ { "id": "NP_001029217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029217", "type": "external" } ], "gene_names_uniprotkb": "MAP2K6", "gene_names_refseq": "MAP2K6", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 6; 2.7.12.2; MAP kinase kinase 6; MAPK/ERK kinase 6; MAPKK 6; MEK 6", "protein_names_refseq": "MAP kinase kinase 6; MAPK/ERK kinase 6; MAPKK 6; MEK 6; dual specificity mitogen-activated protein kinase kinase 6", "tax_id": 9913, "disease": "", "pathway": " (bta:286883); (R-BTA-168638); (R-BTA-2559580); (R-BTA-450302); (R-BTA-6811555); (R-BTA-9020702); (R-BTA-9833482)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004708 MAP kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000165 MAPK cascade;GO:0006915 apoptotic process;GO:0060348 bone development;GO:0001649 osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5E9X2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8HXQ5-1", "uniprot_id": [ { "id": "MRP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8HXQ5", "type": "external" } ], "mass": 171666.0, "length": 1530, "protein_name": "Multidrug resistance-associated protein 1", "gene_name": "ABCC1", "organism": "Bovine", "refseq_name": "multidrug resistance-associated protein 1", "refseq_ac": [ { "id": "NP_776648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776648", "type": "external" } ], "gene_names_uniprotkb": "ABCC1; MRP1", "gene_names_refseq": "ABCC1", "protein_names_uniprotkb": "Multidrug resistance-associated protein 1; 7.6.2.2; 7.6.2.3; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; LTC4 transporter; Leukotriene C(4) transporter", "protein_names_refseq": "ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; LTC4 transporter; glutathione-S-conjugate-translocating ATPase ABCC1; leukotriene C(4) transporter; multidrug resistance-associated protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:281588); (R-BTA-1660661); (R-BTA-189483); (R-BTA-2142691); (R-BTA-382556); (R-BTA-9707564); (R-BTA-9753281); (R-BTA-9758890)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "12067707;24934296;28238471;33469960", "class_list": "", "function": "Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:12067707). Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (By similarity). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (By similarity). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; P-gp, Bcrp and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport., [RefSeq, PubMed]; Study on functional sites in human multidrug resistance protein 1 (hMRP1)., [RefSeq, PubMed]; Using electron cryomicroscopy, authors determined the molecular structures of bovine MRP1 in two conformations: an apo form at 3.5 A without any added substrate and a complex form at 3.3 A with one of its physiological substrates, leukotriene C4; structures show that by forming a single bipartite binding site, MRP1 can recognize a of substrates with different chemical structures., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity;GO:0046943 carboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0050729 positive regulation of inflammatory response;GO:0009410 response to xenobiotic stimulus;GO:0034775 glutathione transmembrane transport;GO:0042908 xenobiotic transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8HXQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MNL4-1", "uniprot_id": [ { "id": "F1MNL4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MNL4", "type": "external" } ], "mass": 159489.0, "length": 1460, "protein_name": "Neogenin", "gene_name": "NEO1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NEO1", "gene_names_refseq": "", "protein_names_uniprotkb": "Neogenin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045296 cadherin binding;GO:0070700 BMP receptor binding;GO:0039706 co-receptor binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0098978 glutamatergic synapse;GO:0097708 intracellular vesicle;GO:0009986 cell surface", "go_biological_process": "GO:0007155 cell adhesion;GO:0001764 neuron migration;GO:0098609 cell-cell adhesion;GO:0007411 axon guidance;GO:0099550 trans-synaptic signaling, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MNL4-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BIU8-1", "uniprot_id": [ { "id": "E1BIU8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BIU8", "type": "external" } ], "mass": 221066.0, "length": 1990, "protein_name": "Receptor-type tyrosine-protein phosphatase S", "gene_name": "PTPRS", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTPRS", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase S; 3.1.3.48; Receptor-type tyrosine-protein phosphatase sigma", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-388844); (R-BTA-8849932)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity;GO:0008201 heparin binding;GO:0035374 chondroitin sulfate binding", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030426 growth cone;GO:0043204 perikaryon", "go_biological_process": "GO:0007155 cell adhesion;GO:0050808 synapse organization;GO:0007165 signal transduction;GO:0050804 modulation of chemical synaptic transmission;GO:0061000 negative regulation of dendritic spine development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BIU8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MP23-1", "uniprot_id": [ { "id": "F1MP23_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MP23", "type": "external" } ], "mass": 80211.0, "length": 714, "protein_name": "Frizzled-6", "gene_name": "FZD6", "organism": "Bovine", "refseq_name": "frizzled-6", "refseq_ac": [ { "id": "XP_003586952", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586952", "type": "external" } ], "gene_names_uniprotkb": "FZD6", "gene_names_refseq": "FZD6", "protein_names_uniprotkb": "Frizzled-6", "protein_names_refseq": "frizzled-6", "tax_id": 9913, "disease": "", "pathway": " (bta:445418); (R-BTA-4086398); (R-BTA-4086400); (R-BTA-4641263)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0031625 ubiquitin protein ligase binding;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0016324 apical plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0060070 canonical Wnt signaling pathway;GO:0035567 non-canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MP23-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MAY4-1", "uniprot_id": [ { "id": "F1MAY4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MAY4", "type": "external" } ], "mass": 232676.0, "length": 2025, "protein_name": "Coiled-coil domain containing 88A", "gene_name": "CCDC88A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CCDC88A", "gene_names_refseq": "", "protein_names_uniprotkb": "Coiled-coil domain containing 88A", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9696264); (R-BTA-9696273)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0051959 dynein light intermediate chain binding;GO:0003779 actin binding;GO:0005158 insulin receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0030705 cytoskeleton-dependent intracellular transport;GO:0031122 cytoplasmic microtubule organization;GO:0016477 cell migration;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MAY4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9GL30-1", "uniprot_id": [ { "id": "LYLAP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9GL30", "type": "external" } ], "mass": 62556.0, "length": 545, "protein_name": "Lysosomal leucine aminopeptidase", "gene_name": "PLBD1", "organism": "Bovine", "refseq_name": "lysosomal leucine aminopeptidase isoform b precursor", "refseq_ac": [ { "id": "NP_001094514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094514", "type": "external" } ], "gene_names_uniprotkb": "PLBD1", "gene_names_refseq": "LyLAP; PLBD1", "protein_names_uniprotkb": "Lysosomal leucine aminopeptidase; 3.4.11.-; LAMA-like protein 1; Lamina ancestor homolog 1; LyLAP; Phospholipase B domain-containing protein 1; Phospholipase B-like 1", "protein_names_refseq": "LAMA-like protein 1; lamina ancestor homolog 1; lysosomal leucine aminopeptidase isoform b precursor; lysosomal leucine aminopeptidase; phospholipase B domain-containing protein 1; putative phospholipase B-like 1", "tax_id": 9913, "disease": "", "pathway": " (bta:317710); (R-BTA-1482788); (R-BTA-1482839); (R-BTA-1482922); (R-BTA-1483115)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "19393038;23934913", "class_list": "", "function": "Based on crystallographic analysis, bovine PLBD1 may be an amidase or peptidase instead of lipase., [RefSeq, PubMed]; Lysosomal processive monoaminopeptidase that preferentially cleaves hydrophobic amino acids, with strong preference for leucine residues. Plays a key role in the degradation of hydrophobic transmembrane domains within the lysosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A6QPQ7;F1MBV7", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:1905146 lysosomal protein catabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9GL30-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZCD7-1", "uniprot_id": [ { "id": "TECR_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3ZCD7", "type": "external" } ], "mass": 36072.0, "length": 308, "protein_name": "Very-long-chain enoyl-CoA reductase", "gene_name": "TECR", "organism": "Bovine", "refseq_name": "very-long-chain enoyl-CoA reductase", "refseq_ac": [ { "id": "NP_001029920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029920", "type": "external" } ], "gene_names_uniprotkb": "TECR; GPSN2", "gene_names_refseq": "GPSN2; TECR", "protein_names_uniprotkb": "Very-long-chain enoyl-CoA reductase; 1.3.1.93; Synaptic glycoprotein SC2; TER; Trans-2,3-enoyl-CoA reductase", "protein_names_refseq": "TER; glycoprotein, synaptic 2; synaptic glycoprotein SC2; very-long-chain enoyl-CoA reductase", "tax_id": 9913, "disease": "", "pathway": " (bta:614105); (R-BTA-75876)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (By similarity). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (By similarity). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (By similarity). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (By similarity). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.-", "type": "external" }, { "id": "1.3.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.93", "type": "external" } ], "go_molecular_function": "GO:0102758 very-long-chain enoyl-CoA reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0006694 steroid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3ZCD7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PF2-1", "uniprot_id": [ { "id": "ACLY_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32PF2", "type": "external" } ], "mass": 119789.0, "length": 1091, "protein_name": "ATP-citrate synthase", "gene_name": "ACLY", "organism": "Bovine", "refseq_name": "ATP-citrate synthase", "refseq_ac": [ { "id": "NP_001032534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032534", "type": "external" } ], "gene_names_uniprotkb": "ACLY", "gene_names_refseq": "ACLY", "protein_names_uniprotkb": "ATP-citrate synthase; 2.3.3.8; ATP-citrate (pro-S-)-lyase; Citrate cleavage enzyme", "protein_names_refseq": "ATP-citrate (pro-S-)-lyase; ATP-citrate synthase; citrate cleavage enzyme", "tax_id": 9913, "disease": "", "pathway": " (bta:511135); (R-BTA-6798695); (R-BTA-75105)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "27421004", "class_list": "", "function": "Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; We identified three non-synonymous mutations in ACLY exons in five beef cattle populations. Single nucleotide polymorphism (SNP) g.17127C>T is significantly associated with chest girth and body height, and with body slanting length. SNP g.40427T>C is significantly associated with an increase in chest girth. ACLY gene are associated with growth traits in beef cattle in northwest China Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003878 ATP citrate synthase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006101 citrate metabolic process;GO:0008610 lipid biosynthetic process;GO:0006633 fatty acid biosynthetic process;GO:0006085 acetyl-CoA biosynthetic process;GO:0006107 oxaloacetate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32PF2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYS6-1", "uniprot_id": [ { "id": "CHP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYS6", "type": "external" } ], "mass": 22442.0, "length": 195, "protein_name": "Calcineurin B homologous protein 1", "gene_name": "CHP1", "organism": "Bovine", "refseq_name": "calcineurin B homologous protein 1", "refseq_ac": [ { "id": "NP_001069044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069044", "type": "external" } ], "gene_names_uniprotkb": "CHP1; CHP", "gene_names_refseq": "CHP1; CHP", "protein_names_uniprotkb": "Calcineurin B homologous protein 1; Calcineurin B-like protein; Calcium-binding protein CHP; Calcium-binding protein p22; EF-hand calcium-binding domain-containing protein p22", "protein_names_refseq": "EF-hand calcium-binding domain-containing protein p22; calcineurin B homologous protein 1; calcineurin B homolog; calcineurin B-like protein; calcineurin homologous protein; calcium binding protein P22; calcium-binding protein CHP; calcium-binding protein p22", "tax_id": 9913, "disease": "", "pathway": " (bta:512662); (R-BTA-2160916)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0008017 microtubule binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:0006469 negative regulation of protein kinase activity;GO:0061024 membrane organization;GO:0050821 protein stabilization;GO:0006883 intracellular sodium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SYS6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZC42-1", "uniprot_id": [ { "id": "ADHX_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3ZC42", "type": "external" } ], "mass": 39677.0, "length": 374, "protein_name": "Alcohol dehydrogenase class-3", "gene_name": "ADH5", "organism": "Bovine", "refseq_name": "alcohol dehydrogenase class-3", "refseq_ac": [ { "id": "NP_001029421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029421", "type": "external" } ], "gene_names_uniprotkb": "ADH5", "gene_names_refseq": "ADH5", "protein_names_uniprotkb": "Alcohol dehydrogenase class-3; 1.1.1.-; 1.1.1.1; 1.1.1.284; Alcohol dehydrogenase 5; Alcohol dehydrogenase class-III; FALDH; FDH; GSH-FDH; Glutathione-dependent formaldehyde dehydrogenase; S-(hydroxymethyl)glutathione dehydrogenase", "protein_names_refseq": "FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase; alcohol dehydrogenase class-3; alcohol dehydrogenase class-III; glutathione-dependent formaldehyde dehydrogenase", "tax_id": 9913, "disease": "", "pathway": " (bta:505515); (R-BTA-71384)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.1", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.284", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.284", "type": "external" } ], "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0005504 fatty acid binding;GO:0008270 zinc ion binding;GO:0018467 formaldehyde dehydrogenase (NAD+) activity;GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0046294 formaldehyde catabolic process;GO:0051775 response to redox state;GO:0010430 fatty acid omega-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3ZC42-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T0T0-1", "uniprot_id": [ { "id": "GDE1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T0T0", "type": "external" } ], "mass": 37653.0, "length": 331, "protein_name": "Glycerophosphodiester phosphodiesterase 1", "gene_name": "GDE1", "organism": "Bovine", "refseq_name": "glycerophosphodiester phosphodiesterase 1", "refseq_ac": [ { "id": "NP_001029858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029858", "type": "external" } ], "gene_names_uniprotkb": "GDE1; MIR16", "gene_names_refseq": "GDE1; MIR16", "protein_names_uniprotkb": "Glycerophosphodiester phosphodiesterase 1; 3.1.4.-; 3.1.4.44; Glycerophosphoinositol glycerophosphodiesterase GDE1; Lysophospholipase D GDE1; Membrane-interacting protein of RGS16", "protein_names_refseq": "glycerophosphodiester phosphodiesterase 1; glycerophosphoinositol glycerophosphodiesterase GDE1; lysophospholipase D GDE1; membrane interacting protein of RGS16", "tax_id": 9913, "disease": "", "pathway": " (bta:539978); (R-BTA-6814848)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.44", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008889 glycerophosphodiester phosphodiesterase activity;GO:0047395 glycerophosphoinositol glycerophosphodiesterase activity;GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0006580 ethanolamine metabolic process;GO:0070291 N-acylethanolamine metabolic process;GO:0006644 phospholipid metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T0T0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNG8-1", "uniprot_id": [ { "id": "E1BNG8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNG8", "type": "external" } ], "mass": 64296.0, "length": 587, "protein_name": "Myc box-dependent-interacting protein 1", "gene_name": "BIN1", "organism": "Bovine", "refseq_name": "myc box-dependent-interacting protein 1 isoform X2", "refseq_ac": [ { "id": "XP_005202274", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202274", "type": "external" } ], "gene_names_uniprotkb": "BIN1", "gene_names_refseq": "BIN1", "protein_names_uniprotkb": "Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Bridging integrator 1", "protein_names_refseq": "myc box-dependent-interacting protein 1 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8856828)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0048156 tau protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0030424 axon;GO:0030315 T-tubule;GO:0005737 cytoplasm", "go_biological_process": "GO:0006897 endocytosis;GO:0030100 regulation of endocytosis;GO:0030154 cell differentiation;GO:0051649 establishment of localization in cell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BNG8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BI64-1", "uniprot_id": [ { "id": "SETD6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BI64", "type": "external" } ], "mass": 51097.0, "length": 450, "protein_name": "N-lysine methyltransferase SETD6", "gene_name": "SETD6", "organism": "Bovine", "refseq_name": "N-lysine methyltransferase SETD6", "refseq_ac": [ { "id": "NP_001091571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091571", "type": "external" } ], "gene_names_uniprotkb": "SETD6", "gene_names_refseq": "SETD6", "protein_names_uniprotkb": "N-lysine methyltransferase SETD6; 2.1.1.-; SET domain-containing protein 6", "protein_names_refseq": "N-lysine methyltransferase SETD6; SET domain-containing protein 6", "tax_id": 9913, "disease": "", "pathway": " (bta:539651); (R-BTA-3214841)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity). Methylates PAK4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D7G4", "ec_number_list": [ { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.4.24.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.71", "type": "external" } ], "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048863 stem cell differentiation;GO:0050727 regulation of inflammatory response;GO:0019827 stem cell population maintenance;GO:0018026 peptidyl-lysine monomethylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BI64-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKE7-1", "uniprot_id": [ { "id": "E1BKE7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKE7", "type": "external" } ], "mass": 303821.0, "length": 2670, "protein_name": "Inositol 1,4,5-trisphosphate receptor", "gene_name": "ITPR3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ITPR3", "gene_names_refseq": "", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-114508); (R-BTA-139853); (R-BTA-381676); (R-BTA-5578775); (R-BTA-9717207); (R-BTA-983695)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0030141 secretory granule;GO:0005789 endoplasmic reticulum membrane;GO:0030658 transport vesicle membrane;GO:0098554 cytoplasmic side of endoplasmic reticulum membrane", "go_biological_process": "GO:0051209 release of sequestered calcium ion into cytosol;GO:0051289 protein homotetramerization;GO:0051592 response to calcium ion;GO:0030168 platelet activation;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BKE7-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8HYJ9-1", "uniprot_id": [ { "id": "FMO3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8HYJ9", "type": "external" } ], "mass": 60093.0, "length": 532, "protein_name": "Flavin-containing monooxygenase 3", "gene_name": "FMO3", "organism": "Bovine", "refseq_name": "flavin-containing monooxygenase 3", "refseq_ac": [ { "id": "NP_776482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776482", "type": "external" } ], "gene_names_uniprotkb": "FMO3", "gene_names_refseq": "FM03; FMO3", "protein_names_uniprotkb": "Flavin-containing monooxygenase 3; 1.14.13.148; 1.14.13.32; 1.14.13.8; Dimethylaniline monooxygenase [N-oxide-forming] 3; Dimethylaniline oxidase 3; FMO 3; Hepatic flavin-containing monooxygenase 3; Trimethylamine monooxygenase", "protein_names_refseq": "FMO 3; dimethylaniline monooxygenase [N-oxide-forming] 3; dimethylaniline oxidase 3; flavin containing monooxygenase 3; flavin-containing monooxygenase 3; hepatic flavin-containing monooxygenase 3; trimethylamine monooxygenase", "tax_id": 9913, "disease": "", "pathway": " (bta:281167); (R-BTA-217271)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12466292", "class_list": "", "function": "Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Fishy off-flavor in cow's milk is caused by a nonsense mutation (R238X) in FMO3, found to be surprisingly common (q = 0.155) in the Swedish Red and White breed of dairy cattle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.13.148", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.148", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" }, { "id": "1.14.13.32", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.32", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0034899 trimethylamine monooxygenase activity;GO:0050661 NADP binding;GO:0004499 N,N-dimethylaniline monooxygenase activity;GO:0047638 albendazole monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042412 taurine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8HYJ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BP36-1", "uniprot_id": [ { "id": "MMS19_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BP36", "type": "external" } ], "mass": 113112.0, "length": 1030, "protein_name": "MMS19 nucleotide excision repair protein homolog", "gene_name": "MMS19", "organism": "Bovine", "refseq_name": "MMS19 nucleotide excision repair protein homolog isoform X1", "refseq_ac": [ { "id": "XP_005225615", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225615", "type": "external" } ], "gene_names_uniprotkb": "MMS19", "gene_names_refseq": "MMS19", "protein_names_uniprotkb": "MMS19 nucleotide excision repair protein homolog; MMS19-like protein", "protein_names_refseq": "MMS19 nucleotide excision repair protein homolog isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:533499)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target Fe/S proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As a CIA complex component and in collaboration with CIAO1 and CIAO2, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QPX1;F1MUW1", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0071817 MMXD complex;GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0007059 chromosome segregation;GO:0051604 protein maturation;GO:0016226 iron-sulfur cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BP36-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MJ58-1", "uniprot_id": [ { "id": "F1MJ58_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MJ58", "type": "external" } ], "mass": 107283.0, "length": 944, "protein_name": "Protein ECT2", "gene_name": "ECT2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ECT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein ECT2; Epithelial cell-transforming sequence 2 oncogene", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-416482); (R-BTA-8980692); (R-BTA-9013148)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005923 bicellular tight junction;GO:0032154 cleavage furrow", "go_biological_process": "GO:0007399 nervous system development;GO:0015031 protein transport;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MJ58-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q865B7-1", "uniprot_id": [ { "id": "PRGC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q865B7", "type": "external" } ], "mass": 90309.0, "length": 796, "protein_name": "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "gene_name": "PPARGC1A", "organism": "Bovine", "refseq_name": "peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "refseq_ac": [ { "id": "NP_808814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808814", "type": "external" } ], "gene_names_uniprotkb": "PPARGC1A; PGC1A; PGC1; PPARGC1", "gene_names_refseq": "PPARGC-1A; PPARGC1A", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha", "protein_names_refseq": "PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:338446); (R-BTA-9841922)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15781588;17517737;19665052;20154154;23342912;24197695;24778332;27468856;33829059", "class_list": "", "function": "Data show that two SNPs (Single Nucleotide Polymorphisms) were identified within exon 8 by multiple alignment of DNA sequences obtained from 24 bulls: a transition G/A (SNP 1181) and a transversion A/T (SNP 1299)., [RefSeq, PubMed]; Genetic Association of PPARGC1A Gene Single Nucleotide Polymorphism with Milk Production Traits in Italian Mediterranean Buffalo. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic analysis of bovine PPARGC1A, [RefSeq, PubMed]; PPARGC1A genotypes had a significant effect on lengths of calving interval and calving to conception interval, and the T allele was demonstrated to have an unfavourable effect on these traits., [RefSeq, PubMed]; PPARGC1A single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle. Publication Status: Online-Only, [RefSeq, PubMed]; PPARGC1A was associated with a significant increase in milk protein percentage in contrast to association results previously reported for the German Holstein population, [RefSeq, PubMed]; Regulatory role in intramuscular fat deposition, [RefSeq, PubMed]; The PPARGC1A synonymous mutation c.396G>A significantly associated with body weight and average daily gain in Nanyang cattle at the adult age., [RefSeq, PubMed]; The effects of dietary fat components on the expression of PPAR-gamma AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported., [RefSeq, PubMed]; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (By similarity). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4L229", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0031490 chromatin DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0097009 energy homeostasis;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q865B7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32L65-1", "uniprot_id": [ { "id": "MARH2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32L65", "type": "external" } ], "mass": 26875.0, "length": 245, "protein_name": "E3 ubiquitin-protein ligase MARCHF2", "gene_name": "MARCHF2", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase MARCHF2", "refseq_ac": [ { "id": "NP_001032678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032678", "type": "external" } ], "gene_names_uniprotkb": "MARCHF2; MARCH2; RNF172", "gene_names_refseq": "MARCH2; MARCHF2; RNF172", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF2; 2.3.2.27; MARCH-II; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING finger protein 172; RING-type E3 ubiquitin transferase MARCHF2; RNF172", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH2; E3 ubiquitin-protein ligase MARCHF2; MARCH-II; RING finger protein 172; RING-type E3 ubiquitin transferase MARCH2; RING-type E3 ubiquitin transferase MARCHF2; membrane-associated RING finger protein 2; membrane-associated RING-CH protein II; membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase", "tax_id": 9913, "disease": "", "pathway": " (bta:508949)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (By similarity). Ubiquitinates and therefore mediates the degradation of DLG1 (By similarity). Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (By similarity). Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation (By similarity). May be involved in endosomal trafficking through interaction with STX6., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0044790 suppression of viral release by host;GO:1905167 positive regulation of lysosomal protein catabolic process;GO:0006897 endocytosis;GO:0016567 protein ubiquitination;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32L65-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPD5-1", "uniprot_id": [ { "id": "F1MPD5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPD5", "type": "external" } ], "mass": 106408.0, "length": 946, "protein_name": "DNA (cytosine-5)-methyltransferase 3A", "gene_name": "DNMT3A", "organism": "Bovine", "refseq_name": "DNA (cytosine-5)-methyltransferase 3A isoform X2", "refseq_ac": [ { "id": "XP_059747018", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747018", "type": "external" } ], "gene_names_uniprotkb": "DNMT3A", "gene_names_refseq": "DNMT3A", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase 3A; 2.1.1.37; Cysteine methyltransferase DNMT3A", "protein_names_refseq": "DNA (cytosine-5)-methyltransferase 3A isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-212300); (R-BTA-3214858)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" } ], "go_molecular_function": "GO:0003886 DNA (cytosine-5-)-methyltransferase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0006325 chromatin organization;GO:0010468 regulation of gene expression;GO:0032259 methylation;GO:0045892 negative regulation of DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MPD5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7V7-1", "uniprot_id": [ { "id": "E1B7V7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7V7", "type": "external" } ], "mass": 107645.0, "length": 954, "protein_name": "Nucleotide-binding oligomerization domain-containing protein 1", "gene_name": "NOD1", "organism": "Bovine", "refseq_name": "nucleotide-binding oligomerization domain-containing protein 1", "refseq_ac": [ { "id": "XP_005205565", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205565", "type": "external" } ], "gene_names_uniprotkb": "NOD1", "gene_names_refseq": "NOD1", "protein_names_uniprotkb": "Nucleotide-binding oligomerization domain-containing protein 1", "protein_names_refseq": "caspase recruitment domain protein 4; nucleotide-binding oligomerization domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0005524 ATP binding;GO:0038187 pattern recognition receptor activity;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0005829 cytosol;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0045087 innate immune response;GO:0006915 apoptotic process;GO:0001819 positive regulation of cytokine production;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7V7-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SPJ1-1", "uniprot_id": [ { "id": "PLAK_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8SPJ1", "type": "external" } ], "mass": 81821.0, "length": 745, "protein_name": "Junction plakoglobin", "gene_name": "JUP", "organism": "Bovine", "refseq_name": "junction plakoglobin", "refseq_ac": [ { "id": "NP_001004024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004024", "type": "external" } ], "gene_names_uniprotkb": "JUP", "gene_names_refseq": "JUP", "protein_names_uniprotkb": "Junction plakoglobin; Desmoplakin III; Desmoplakin-3", "protein_names_refseq": "desmoplakin III; desmoplakin-3; junction plakoglobin", "tax_id": 9913, "disease": "", "pathway": " (bta:445543); (R-BTA-418990); (R-BTA-5218920); (R-BTA-6798695); (R-BTA-6805567); (R-BTA-6809371); (R-BTA-8980692); (R-BTA-9013106); (R-BTA-9013406); (R-BTA-9013407); (R-BTA-9762292); (R-BTA-9764561); (R-BTA-9766229); (R-BTA-9768727); (R-BTA-9958810); (R-BTA-9958825)", "pathway_count": 16, "publication_count": 1, "publication_id_list": "41018975", "class_list": "", "function": "Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q17QY6", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042803 protein homodimerization activity;GO:0045296 cadherin binding;GO:0019903 protein phosphatase binding;GO:0045294 alpha-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005912 adherens junction", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0071603 endothelial cell-cell adhesion;GO:0016477 cell migration;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8SPJ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MDF3-1", "uniprot_id": [ { "id": "F1MDF3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MDF3", "type": "external" } ], "mass": 183221.0, "length": 1656, "protein_name": "Alsin", "gene_name": "ALS2", "organism": "Bovine", "refseq_name": "alsin isoform X1", "refseq_ac": [ { "id": "XP_002685556", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685556", "type": "external" } ], "gene_names_uniprotkb": "ALS2", "gene_names_refseq": "ALS2", "protein_names_uniprotkb": "Alsin", "protein_names_refseq": "alsin isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:535750); (R-BTA-8876198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a GTPase regulator. Controls survival and growth of spinal motoneurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005096 GTPase activator activity;GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005769 early endosome", "go_biological_process": "GO:0048812 neuron projection morphogenesis;GO:0016197 endosomal transport;GO:0051036 regulation of endosome size;GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MDF3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q137-1", "uniprot_id": [ { "id": "SEPT7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q6Q137", "type": "external" } ], "mass": 50680.0, "length": 437, "protein_name": "Septin-7", "gene_name": "SEPTIN7", "organism": "Bovine", "refseq_name": "septin-7", "refseq_ac": [ { "id": "NP_001001168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001168", "type": "external" } ], "gene_names_uniprotkb": "SEPTIN7; CDC10; SEPT7", "gene_names_refseq": "CDC10; SEPT7; SEPTIN7", "protein_names_uniprotkb": "Septin-7; CDC10 protein homolog", "protein_names_refseq": "CDC10 protein homolog; cell division cycle 10; septin-7", "tax_id": 9913, "disease": "", "pathway": " (bta:408000)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25691006;34097585", "class_list": "", "function": "A SNP in the CDC10 gene was associated with growth-related traits in Japanese Black beef cattle, [RefSeq, PubMed]; A novel indel within the bovine SEPT7 gene is associated with ovary length., [RefSeq, PubMed]; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005940 septin ring;GO:0005634 nucleus;GO:0005819 spindle;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007010 cytoskeleton organization;GO:0060271 cilium assembly;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6Q137-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58D31-1", "uniprot_id": [ { "id": "DHSO_BOVIN", "url": "https://www.uniprot.org/uniprot/Q58D31", "type": "external" } ], "mass": 38099.0, "length": 356, "protein_name": "Sorbitol dehydrogenase", "gene_name": "SORD", "organism": "Bovine", "refseq_name": "sorbitol dehydrogenase", "refseq_ac": [ { "id": "NP_001032397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032397", "type": "external" } ], "gene_names_uniprotkb": "SORD", "gene_names_refseq": "SDH; SORD; XDH", "protein_names_uniprotkb": "Sorbitol dehydrogenase; 1.1.1.-; 1.1.1.14; 1.1.1.9; L-iditol 2-dehydrogenase; Polyol dehydrogenase; SDH; XDH; Xylitol dehydrogenase", "protein_names_refseq": "L-iditol 2-dehydrogenase; polyol dehydrogenase; sorbitol dehydrogenase; xylitol dehydrogenase", "tax_id": 9913, "disease": "", "pathway": " (bta:508954); (R-BTA-5652227); (R-BTA-5661270)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16305752;9143345", "class_list": "", "function": "Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0II66", "ec_number_list": [ { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.14", "type": "external" }, { "id": "1.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.9", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003939 L-iditol 2-dehydrogenase (NAD+) activity;GO:0046526 D-xylulose reductase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031514 motile cilium;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0046370 fructose biosynthetic process;GO:0006062 sorbitol catabolic process;GO:0019640 D-glucuronate catabolic process to D-xylulose 5-phosphate", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q58D31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MJW3-1", "uniprot_id": [ { "id": "SCNNG_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MJW3", "type": "external" } ], "mass": 74321.0, "length": 652, "protein_name": "Epithelial sodium channel subunit gamma", "gene_name": "SCNN1G", "organism": "Bovine", "refseq_name": "epithelial sodium channel subunit gamma", "refseq_ac": [ { "id": "NP_001180103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180103", "type": "external" } ], "gene_names_uniprotkb": "SCNN1G", "gene_names_refseq": "SCNEG; SCNN1G", "protein_names_uniprotkb": "Epithelial sodium channel subunit gamma; Amiloride-sensitive sodium channel subunit gamma", "protein_names_refseq": "amiloride-sensitive sodium channel subunit gamma; epithelial Na(+) channel subunit gamma; epithelial sodium channel subunit gamma; gamma-ENaC; gamma-NaCH; nonvoltage-gated sodium channel 1 subunit gamma; sodium channel epithelial 1 gamma subunit; sodium channel, non-voltage-gated 1, gamma subunit; sodium channel, nonvoltage-gated 1, gamma", "tax_id": 9913, "disease": "", "pathway": " (bta:617802); (R-BTA-2672351); (R-BTA-9730628)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0050699 WW domain binding;GO:0015280 ligand-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0034706 sodium channel complex;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006883 intracellular sodium ion homeostasis;GO:0035725 sodium ion transmembrane transport;GO:0098719 sodium ion import across plasma membrane;GO:0050891 multicellular organismal-level water homeostasis;GO:0071468 cellular response to acidic pH", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MJW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EAD4-1", "uniprot_id": [ { "id": "ACDSB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5EAD4", "type": "external" } ], "mass": 47123.0, "length": 432, "protein_name": "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "ACADSB", "organism": "Bovine", "refseq_name": "short/branched chain specific acyl-CoA dehydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_001017933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017933", "type": "external" } ], "gene_names_uniprotkb": "ACADSB", "gene_names_refseq": "ACADSB", "protein_names_uniprotkb": "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.1; 1.3.8.5; 2-MEBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; 2-methylbutyryl-coenzyme A dehydrogenase; SBCAD", "protein_names_refseq": "2-MEBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; 2-methylbutyryl-coenzyme A dehydrogenase; SBCAD; acyl-Coenzyme A dehydrogenase, short/branched chain; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:504301); (R-BTA-70895); (R-BTA-9837999)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway. Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "1.3.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding;GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity;GO:0003853 short-chain 2-methyl fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006550 L-isoleucine catabolic process;GO:0046395 carboxylic acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5EAD4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQ39-1", "uniprot_id": [ { "id": "F1MQ39_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQ39", "type": "external" } ], "mass": 73390.0, "length": 657, "protein_name": "Growth hormone receptor", "gene_name": "GHR", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GHR", "gene_names_refseq": "", "protein_names_uniprotkb": "Growth hormone receptor; Somatotropin receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004896 cytokine receptor activity;GO:0042803 protein homodimerization activity;GO:0017046 peptide hormone binding;GO:0004903 growth hormone receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0009986 cell surface", "go_biological_process": "GO:0006897 endocytosis;GO:0042445 hormone metabolic process;GO:0048009 insulin-like growth factor receptor signaling pathway;GO:0040018 positive regulation of multicellular organism growth;GO:0060396 growth hormone receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQ39-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCG5-1", "uniprot_id": [ { "id": "E1BCG5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCG5", "type": "external" } ], "mass": 100961.0, "length": 882, "protein_name": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1", "gene_name": "NDST1", "organism": "Bovine", "refseq_name": "bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1", "refseq_ac": [ { "id": "NP_001179290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179290", "type": "external" } ], "gene_names_uniprotkb": "NDST1", "gene_names_refseq": "NDST1", "protein_names_uniprotkb": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; 2.8.2.8; Glucosaminyl N-deacetylase/N-sulfotransferase 1", "protein_names_refseq": "N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:514172); (R-BTA-2022928)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.8", "type": "external" }, { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0019213 deacetylase activity;GO:0015016 heparan sulfate N-sulfotransferase activity;GO:0050119 N-acetylglucosamine deacetylase activity;GO:0102140 heparan sulfate N-deacetylase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0030210 heparin proteoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCG5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZH7-1", "uniprot_id": [ { "id": "LKHA4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZH7", "type": "external" } ], "mass": 69306.0, "length": 611, "protein_name": "Leukotriene A-4 hydrolase", "gene_name": "LTA4H", "organism": "Bovine", "refseq_name": "leukotriene A-4 hydrolase", "refseq_ac": [ { "id": "NP_001029452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029452", "type": "external" } ], "gene_names_uniprotkb": "LTA4H", "gene_names_refseq": "LTA4H", "protein_names_uniprotkb": "Leukotriene A-4 hydrolase; 3.3.2.6; 3.4.11.4; LTA-4 hydrolase; Leukotriene A(4) hydrolase; Tripeptide aminopeptidase LTA4H", "protein_names_refseq": "LTA-4 hydrolase; leukotriene A-4 hydrolase; tripeptide aminopeptidase LTA4H", "tax_id": 9913, "disease": "", "pathway": " (bta:507130); (R-BTA-2142691); (R-BTA-6798695); (R-BTA-9018676); (R-BTA-9018681); (R-BTA-9018896); (R-BTA-9020265); (R-BTA-9023661)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4), as well as other lipid epoxides. Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides. In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0004301 epoxide hydrolase activity;GO:0004463 leukotriene-A4 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process;GO:0019370 leukotriene biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZH7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5E9S9-1", "uniprot_id": [ { "id": "S38A5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5E9S9", "type": "external" } ], "mass": 51958.0, "length": 478, "protein_name": "Sodium-coupled neutral amino acid transporter 5", "gene_name": "SLC38A5", "organism": "Bovine", "refseq_name": "sodium-coupled neutral amino acid transporter 5", "refseq_ac": [ { "id": "NP_001015580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015580", "type": "external" } ], "gene_names_uniprotkb": "SLC38A5; SNAT5", "gene_names_refseq": "SLC38A5; SN2", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid transporter 5; Solute carrier family 38 member 5; System N transporter 2", "protein_names_refseq": "amino acid transport system N2; sodium-coupled neutral amino acid transporter 5; system N transporter 2", "tax_id": 9913, "disease": "", "pathway": " (bta:512495); (R-BTA-352230)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity. Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-glutamine cycle and the NMDA receptors activation (By similarity). In addition contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells and, therefore participates in the retinal glutamate-glutamine cycle (By similarity). The transport activity is pH sensitive, Li(+) tolerant, bidirectional and associated with large uncoupled fluxes of protons. The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+). May have particular importance for modulation of net hepatic glutamine flux (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VD33", "ec_number_list": [], "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0140830 L-glutamine, sodium:proton antiporter activity;GO:0140893 neutral amino acid, sodium:proton antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0032329 serine transport;GO:0006868 glutamine transport;GO:0015804 neutral amino acid transport;GO:1903803 L-glutamine import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5E9S9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MLY7-1", "uniprot_id": [ { "id": "F1MLY7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MLY7", "type": "external" } ], "mass": 302411.0, "length": 2651, "protein_name": "Serine/threonine-protein kinase ATR", "gene_name": "ATR", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ATR", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase ATR; 2.7.11.1; Ataxia telangiectasia and Rad3-related protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:504869); (R-BTA-176187); (R-BTA-5685938); (R-BTA-5693607); (R-BTA-6783310); (R-BTA-6804756); (R-BTA-69473)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0032405 MutLalpha complex binding;GO:0032407 MutSalpha complex binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005694 chromosome;GO:0070310 ATR-ATRIP complex;GO:0005634 nucleus;GO:0016605 PML body", "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0000077 DNA damage checkpoint signaling;GO:0000723 telomere maintenance;GO:0009612 response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MLY7-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SYZ2-1", "uniprot_id": [ { "id": "MAPK3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SYZ2", "type": "external" } ], "mass": 43316.0, "length": 384, "protein_name": "MAP kinase-activated protein kinase 3", "gene_name": "MAPKAPK3", "organism": "Bovine", "refseq_name": "MAP kinase-activated protein kinase 3", "refseq_ac": [ { "id": "NP_001029951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029951", "type": "external" } ], "gene_names_uniprotkb": "MAPKAPK3", "gene_names_refseq": "MAPKAP-K3; MAPKAPK3; MK-3", "protein_names_uniprotkb": "MAP kinase-activated protein kinase 3; 2.7.11.1; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP-K3; MAPKAPK-3; MK-3", "protein_names_refseq": "MAP kinase-activated protein kinase 3; MAPKAP kinase 3; MAPKAPK-3; mitogen-activated protein kinase-activated protein kinase 3", "tax_id": 9913, "disease": "", "pathway": " (bta:615215); (R-BTA-171007); (R-BTA-2559580); (R-BTA-4420097); (R-BTA-450302)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8M1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051019 mitogen-activated protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0035556 intracellular signal transduction;GO:0000165 MAPK cascade;GO:0034097 response to cytokine;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SYZ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MCH2-1", "uniprot_id": [ { "id": "F1MCH2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MCH2", "type": "external" } ], "mass": 52186.0, "length": 463, "protein_name": "Kynureninase", "gene_name": "KYNU", "organism": "Bovine", "refseq_name": "kynureninase", "refseq_ac": [ { "id": "NP_001178237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178237", "type": "external" } ], "gene_names_uniprotkb": "KYNU", "gene_names_refseq": "KYNU", "protein_names_uniprotkb": "Kynureninase; 3.7.1.3; L-kynurenine hydrolase", "protein_names_refseq": "kynureninase (L-kynurenine hydrolase); kynureninase", "tax_id": 9913, "disease": "", "pathway": " (bta:520327); (R-BTA-71240)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.7.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.7.1.3", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0030429 kynureninase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0006569 L-tryptophan catabolic process;GO:0019805 quinolinate biosynthetic process;GO:0043420 anthranilate metabolic process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MCH2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7N2-1", "uniprot_id": [ { "id": "ACTN1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3B7N2", "type": "external" } ], "mass": 102980.0, "length": 892, "protein_name": "Alpha-actinin-1", "gene_name": "ACTN1", "organism": "Bovine", "refseq_name": "alpha-actinin-1", "refseq_ac": [ { "id": "NP_001030428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030428", "type": "external" } ], "gene_names_uniprotkb": "ACTN1", "gene_names_refseq": "ACTN1", "protein_names_uniprotkb": "Alpha-actinin-1; Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1", "protein_names_refseq": "F-actin cross-linking protein; alpha-actinin-1; non-muscle alpha-actinin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:524770); (R-BTA-114608); (R-BTA-446388); (R-BTA-9013418); (R-BTA-9035034)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding;GO:0051393 alpha-actinin binding;GO:0005509 calcium ion binding;GO:0017166 vinculin binding", "go_cellular_component": "GO:0090636 outer dense plaque of desmosome;GO:0090637 inner dense plaque of desmosome;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0005925 focal adhesion", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0046928 regulation of neurotransmitter secretion;GO:0048741 skeletal muscle fiber development;GO:0045214 sarcomere organization;GO:0043462 regulation of ATP-dependent activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B7N2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZBM4-1", "uniprot_id": [ { "id": "ITBP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3ZBM4", "type": "external" } ], "mass": 21871.0, "length": 200, "protein_name": "Integrin beta-1-binding protein 1", "gene_name": "ITGB1BP1", "organism": "Bovine", "refseq_name": "integrin beta-1-binding protein 1", "refseq_ac": [ { "id": "NP_001029620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029620", "type": "external" } ], "gene_names_uniprotkb": "ITGB1BP1", "gene_names_refseq": "ITGB1BP1", "protein_names_uniprotkb": "Integrin beta-1-binding protein 1", "protein_names_refseq": "integrin beta-1-binding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:513531)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0010764 negative regulation of fibroblast migration;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0006351 DNA-templated transcription;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3ZBM4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZ18-1", "uniprot_id": [ { "id": "HPRT_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZ18", "type": "external" } ], "mass": 24498.0, "length": 218, "protein_name": "Hypoxanthine-guanine phosphoribosyltransferase", "gene_name": "HPRT1", "organism": "Bovine", "refseq_name": "hypoxanthine-guanine phosphoribosyltransferase", "refseq_ac": [ { "id": "NP_001029207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029207", "type": "external" } ], "gene_names_uniprotkb": "HPRT1", "gene_names_refseq": "HGPRT; HPRT1; HPRT", "protein_names_uniprotkb": "Hypoxanthine-guanine phosphoribosyltransferase; 2.4.2.8; HGPRTase; HGPRT", "protein_names_refseq": "HGPRTase; hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome); hypoxanthine-guanine phosphoribosyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:281229); (R-BTA-74217); (R-BTA-9748787)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "12356942", "class_list": "", "function": "Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Levels of G6PD and HPRT RNA were higher in female morulae and blastocysts than in males, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.8", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0004422 hypoxanthine phosphoribosyltransferase activity;GO:0052657 guanine phosphoribosyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046040 IMP metabolic process;GO:0043103 hypoxanthine salvage;GO:0032264 IMP salvage;GO:0045964 positive regulation of dopamine metabolic process;GO:0006166 purine ribonucleoside salvage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SZ18-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32L00-1", "uniprot_id": [ { "id": "ALKB3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32L00", "type": "external" } ], "mass": 33156.0, "length": 286, "protein_name": "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3", "gene_name": "ALKBH3", "organism": "Bovine", "refseq_name": "alpha-ketoglutarate-dependent dioxygenase alkB homolog 3", "refseq_ac": [ { "id": "NP_001032691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032691", "type": "external" } ], "gene_names_uniprotkb": "ALKBH3; ABH3", "gene_names_refseq": "ALKBH3", "protein_names_uniprotkb": "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; 1.14.11.33; 1.14.11.54; Alkylated DNA repair protein alkB homolog 3", "protein_names_refseq": "alkB homolog 3, alpha-ketoglutaratedependent dioxygenase; alkB, alkylation repair homolog 3; alkylated DNA repair protein alkB homolog 3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3", "tax_id": 9913, "disease": "", "pathway": " (bta:514579)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Can repair exocyclic 3,N4-ethenocytosine adducs in single-stranded DNA. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "1.14.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33", "type": "external" }, { "id": "1.14.11.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.54", "type": "external" } ], "go_molecular_function": "GO:0008198 ferrous iron binding;GO:1990930 mRNA N1-methyladenosine dioxygenase activity;GO:0035516 broad specificity oxidative DNA demethylase activity;GO:0046872 metal ion binding;GO:0051213 dioxygenase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0008283 cell population proliferation;GO:0006307 DNA alkylation repair;GO:2000766 negative regulation of cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32L00-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9XT97-1", "uniprot_id": [ { "id": "PSN1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9XT97", "type": "external" } ], "mass": 53654.0, "length": 478, "protein_name": "Presenilin-1", "gene_name": "PSEN1", "organism": "Bovine", "refseq_name": "presenilin-1", "refseq_ac": [ { "id": "NP_777146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777146", "type": "external" } ], "gene_names_uniprotkb": "PSEN1", "gene_names_refseq": "PSEN1", "protein_names_uniprotkb": "Presenilin-1; 3.4.23.-; PS-1", "protein_names_refseq": "PS-1; presenilin 1 (Alzheimer disease 3); presenilin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:282705); (R-BTA-1251985); (R-BTA-193692); (R-BTA-205043); (R-BTA-3928665); (R-BTA-6798695); (R-BTA-9839383)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "22016384", "class_list": "", "function": "Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (By similarity). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (By similarity). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis. Involved in the regulation of neurite outgrowth (By similarity). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1, [RefSeq, PubMed]; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" } ], "go_molecular_function": "GO:0042500 aspartic endopeptidase activity, intramembrane cleaving;GO:0060090 molecular adaptor activity;GO:0005262 calcium channel activity;GO:0051117 ATPase binding;GO:0070851 growth factor receptor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0007155 cell adhesion;GO:0007219 Notch signaling pathway;GO:0016485 protein processing;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9XT97-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6E804-1", "uniprot_id": [ { "id": "NOD2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q6E804", "type": "external" } ], "mass": 112800.0, "length": 1013, "protein_name": "Nucleotide-binding oligomerization domain-containing protein 2", "gene_name": "NOD2", "organism": "Bovine", "refseq_name": "nucleotide-binding oligomerization domain-containing protein 2", "refseq_ac": [ { "id": "NP_001002889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002889", "type": "external" } ], "gene_names_uniprotkb": "NOD2; CARD15", "gene_names_refseq": "CARD15; NOD2", "protein_names_uniprotkb": "Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15", "protein_names_refseq": "caspase recruitment domain 15 protein; caspase recruitment domain-containing protein 15; nucleotide-binding oligomerization domain-containing protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:444867); (R-BTA-168638); (R-BTA-450302); (R-BTA-450321); (R-BTA-5689896)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "16897345;18005441;18926647;25966125;26244859;27853874", "class_list": "", "function": "A significant association was found between two polymorphisms of CARD15 and paratuberculosis status; cows with the heterozygous genotype were 3.35 times more likely to be infected than cows with the reference genotype., [RefSeq, PubMed]; Data indicate six single-nucleotide polymorphisms (SNPs) in the caspase recruitment domain 15 protein (CARD15) gene associated with susceptibility to bovine tuberculosis (BTB) in Chinese Holstein cows. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that the Nod2 signaling adaptor protein (NOD2) G-->A at position 1594 bp plays a critical role in increasing 305-day milk yields. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic variation and putative regulatory regions in bovine CARD15., [RefSeq, PubMed]; Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and plays an important role in gastrointestinal immunity. Specifically activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan found in every bacterial peptidoglycan type. NOD2 specifically recognizes and binds 6-O-phospho-MDP, the phosphorylated form of MDP, which is generated by NAGK. 6-O-phospho-MDP-binding triggers oligomerization that facilitates the binding and subsequent activation of the proximal adapter receptor-interacting RIPK2. Following recruitment, RIPK2 undergoes 'Met-1'- (linear) and 'Lys-63'-linked polyubiquitination by E3 ubiquitin-protein ligases XIAP, BIRC2, BIRC3 and the LUBAC complex, becoming a scaffolding protein for downstream effectors, triggering activation of the NF-kappa-B and MAP kinases signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response (By similarity). Its ability to detect bacterial MDP plays a central role in maintaining the equilibrium between intestinal microbiota and host immune responses to control inflammation. An imbalance in this relationship results in dysbiosis, whereby pathogenic bacteria prevail on commensals, causing damage in the intestinal epithelial barrier as well as allowing bacterial invasion and inflammation. Acts as a regulator of appetite by sensing MDP in a subset of brain neurons: microbiota-derived MDP reach the brain, where they bind and activate NOD2 in inhibitory hypothalamic neurons, decreasing neuronal activity, thereby regulating satiety and body temperature. NOD2-dependent MDP-sensing of bacterial cell walls in the intestinal epithelial compartment contributes to sustained postnatal growth upon undernutrition (By similarity). Also plays a role in antiviral response by acting as a sensor of single-stranded RNA (ssRNA) from viruses: upon ssRNA-binding, interacts with MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon. Also acts as a regulator of autophagy in dendritic cells via its interaction with ATG16L1, possibly by recruiting ATG16L1 at the site of bacterial entry (By similarity). NOD2 activation in the small intestine crypt also contributes to intestinal stem cells survival and function: acts by promoting mitophagy via its association with ATG16L1. In addition to its main role in innate immunity, also regulates the adaptive immune system by acting as regulator of helper T-cell and regulatory T-cells (Tregs) (By similarity). Besides recognizing pathogens, also involved in the endoplasmic reticulum stress response: acts by sensing and binding to the cytosolic metabolite sphingosine-1-phosphate generated in response to endoplasmic reticulum stress, initiating an inflammation process that leads to activation of the NF-kappa-B and MAP kinases signaling. May also be involved in NLRP1 activation following activation by MDP, leading to CASP1 activation and IL1B release in macrophages (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results revealed that thermal stress increased the expression levels of NOD1/2 genes and acute inflammatory cytokines which sheds some light on their role on immune response of the host cells during thermal stress.These preliminary studies indicated that the immune-related genes differentially expressed during thermal stress among native and crossbred cattle., [RefSeq, PubMed]; This study indicates that SNP c.3020A>T might play a role in the host response against mastitis and further detailed studies are needed to understand its functional mechanisms Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0003779 actin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0043531 ADP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0009986 cell surface", "go_biological_process": "GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0002221 pattern recognition receptor signaling pathway;GO:0032740 positive regulation of interleukin-17 production;GO:1901526 positive regulation of mitophagy;GO:0001659 temperature homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6E804-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5E9R6-1", "uniprot_id": [ { "id": "CERS4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5E9R6", "type": "external" } ], "mass": 46363.0, "length": 393, "protein_name": "Ceramide synthase 4", "gene_name": "CERS4", "organism": "Bovine", "refseq_name": "ceramide synthase 4", "refseq_ac": [ { "id": "NP_001015520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015520", "type": "external" } ], "gene_names_uniprotkb": "CERS4; LASS4", "gene_names_refseq": "CERS4; LASS4", "protein_names_uniprotkb": "Ceramide synthase 4; 2.3.1.-; 2.3.1.24; CerS4; LAG1 longevity assurance homolog 4; Sphingosine N-acyltransferase CERS4", "protein_names_refseq": "LAG1 homolog, ceramide synthase 4; LAG1 longevity assurance homolog 4; ceramide synthase 4; sphingosine N-acyltransferase CERS4", "tax_id": 9913, "disease": "", "pathway": " (bta:505233); (R-BTA-1660661)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0V884", "ec_number_list": [ { "id": "2.3.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.24", "type": "external" }, { "id": "2.3.1.297", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.297", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005634 nucleus", "go_biological_process": "GO:0046513 ceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5E9R6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BC36-1", "uniprot_id": [ { "id": "E1BC36_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BC36", "type": "external" } ], "mass": 37014.0, "length": 326, "protein_name": "Cyclin-dependent kinase 4", "gene_name": "CDK6", "organism": "Bovine", "refseq_name": "cyclin-dependent kinase 6", "refseq_ac": [ { "id": "NP_001179230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179230", "type": "external" } ], "gene_names_uniprotkb": "CDK6", "gene_names_refseq": "CDK6", "protein_names_uniprotkb": "Cyclin-dependent kinase 4; 2.7.11.22; Cell division protein kinase 4", "protein_names_refseq": "cyclin-dependent kinase 6", "tax_id": 9913, "disease": "", "pathway": " (bta:511754); (R-BTA-2559580); (R-BTA-2559582); (R-BTA-2559585); (R-BTA-69231); (R-BTA-8934593); (R-BTA-9754119)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "21948744", "class_list": "", "function": "The T-1075C SNP of bovine CDK6 is significantly associated with body length and heart girth Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0098770 FBXO family protein binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0001726 ruffle;GO:0097132 cyclin D2-CDK6 complex", "go_biological_process": "GO:0050680 negative regulation of epithelial cell proliferation;GO:0009615 response to virus;GO:2000773 negative regulation of cellular senescence;GO:0030097 hemopoiesis;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BC36-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZP5-1", "uniprot_id": [ { "id": "ACOX1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZP5", "type": "external" } ], "mass": 74379.0, "length": 660, "protein_name": "Peroxisomal acyl-coenzyme A oxidase 1", "gene_name": "ACOX1", "organism": "Bovine", "refseq_name": "peroxisomal acyl-coenzyme A oxidase 1", "refseq_ac": [ { "id": "NP_001030366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030366", "type": "external" } ], "gene_names_uniprotkb": "ACOX1", "gene_names_refseq": "ACOX1", "protein_names_uniprotkb": "Peroxisomal acyl-coenzyme A oxidase 1; 1.3.3.6; AOX; Palmitoyl-CoA oxidase; Peroxisomal fatty acyl-CoA oxidase; Straight-chain acyl-CoA oxidase", "protein_names_refseq": "AOX; acyl-Coenzyme A oxidase 1, palmitoyl; palmitoyl-CoA oxidase; peroxisomal acyl-coenzyme A oxidase 1; peroxisomal fatty acyl-CoA oxidase; straight-chain acyl-CoA oxidase", "tax_id": 9913, "disease": "", "pathway": " (bta:513996); (R-BTA-2046106); (R-BTA-390247); (R-BTA-9033241)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21948757;33502338", "class_list": "", "function": "ACOX1, regulated by C/EBPalpha and miR-25-3p, promotes bovine preadipocyte adipogenesis., [RefSeq, PubMed]; Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs that have a saturated bond between C2 and C3 (2,3-saturated acyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs), and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2))., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Molecular characterization of the ACOX1 gene; identified one SNP and investigated its association in 7 Bos taurus populations; the A1865C SNP of ACOX1 is significantly associated with ultrasound backfat thickness and ultrasound marbling score in cattle Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" } ], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0003997 acyl-CoA oxidase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0006091 generation of precursor metabolites and energy;GO:0006629 lipid metabolic process;GO:0009062 fatty acid catabolic process;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3SZP5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWW9-1", "uniprot_id": [ { "id": "PP1B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SWW9", "type": "external" } ], "mass": 37187.0, "length": 327, "protein_name": "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "gene_name": "PPP1CB", "organism": "Bovine", "refseq_name": "serine/threonine-protein phosphatase PP1-beta catalytic subunit", "refseq_ac": [ { "id": "NP_001029825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029825", "type": "external" } ], "gene_names_uniprotkb": "PPP1CB", "gene_names_refseq": "PPP1CB", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PP1-beta catalytic subunit; 3.1.3.16; 3.1.3.53; PP-1B", "protein_names_refseq": "PP-1B; serine/threonine-protein phosphatase PP1-beta catalytic subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:538829); (R-BTA-2565942); (R-BTA-5625740); (R-BTA-5627123); (R-BTA-5673000); (R-BTA-9770562)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0050115 myosin-light-chain-phosphatase activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0017018 myosin phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0072357 PTW/PP1 phosphatase complex", "go_biological_process": "GO:0030155 regulation of cell adhesion;GO:0051301 cell division;GO:0005977 glycogen metabolic process;GO:0042752 regulation of circadian rhythm;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWW9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHP1-1", "uniprot_id": [ { "id": "UB2L3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHP1", "type": "external" } ], "mass": 17862.0, "length": 154, "protein_name": "Ubiquitin-conjugating enzyme E2 L3", "gene_name": "UBE2L3", "organism": "Bovine", "refseq_name": "ubiquitin-conjugating enzyme E2 L3", "refseq_ac": [ { "id": "NP_001071562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071562", "type": "external" } ], "gene_names_uniprotkb": "UBE2L3", "gene_names_refseq": "UBE2L3", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 L3; 2.3.2.23; E2 ubiquitin-conjugating enzyme L3; Ubiquitin carrier protein L3; Ubiquitin-protein ligase L3", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme L3; ubiquitin carrier protein L3; ubiquitin-conjugating enzyme E2 L3; ubiquitin-conjugating enzyme E2L 3; ubiquitin-protein ligase L3", "tax_id": 9913, "disease": "", "pathway": " (bta:767894); (R-BTA-5205685); (R-BTA-5357905); (R-BTA-5675482); (R-BTA-8866652); (R-BTA-8866654); (R-BTA-983168)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN, RNF31 and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates ubiquitination by the CUL9-RBX1 complex (By similarity). In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1JPH3", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008283 cell population proliferation;GO:0006355 regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3MHP1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKA3-1", "uniprot_id": [ { "id": "AJUBA_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKA3", "type": "external" } ], "mass": 57765.0, "length": 548, "protein_name": "LIM domain-containing protein ajuba", "gene_name": "AJUBA", "organism": "Bovine", "refseq_name": "LIM domain-containing protein ajuba", "refseq_ac": [ { "id": "NP_001179446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179446", "type": "external" } ], "gene_names_uniprotkb": "AJUBA; JUB", "gene_names_refseq": "AJUBA; JUB", "protein_names_uniprotkb": "LIM domain-containing protein ajuba", "protein_names_refseq": "LIM domain-containing protein ajuba; jub, ajuba homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:519937); (R-BTA-1234176); (R-BTA-2565942); (R-BTA-9841922)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0003714 transcription corepressor activity;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0001666 response to hypoxia;GO:0006355 regulation of DNA-templated transcription;GO:0007010 cytoskeleton organization;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BKA3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BIP1-1", "uniprot_id": [ { "id": "E1BIP1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BIP1", "type": "external" } ], "mass": 44820.0, "length": 399, "protein_name": "P2X purinoceptor", "gene_name": "P2RX1", "organism": "Bovine", "refseq_name": "P2X purinoceptor 1", "refseq_ac": [ { "id": "NP_001192729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192729", "type": "external" } ], "gene_names_uniprotkb": "P2RX1", "gene_names_refseq": "P2RX1", "protein_names_uniprotkb": "P2X purinoceptor; P2X purinoceptor 1", "protein_names_refseq": "P2X purinoceptor 1; purinergic receptor P2X, ligand-gated ion channel, 1", "tax_id": 9913, "disease": "", "pathway": " (bta:514898); (R-BTA-139853); (R-BTA-418346); (R-BTA-6798695)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability. Furthermore, CTP functions as a weak affinity agonist for P2RX1., [UniProtKB, UniProtKB, UniProtKB]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0001614 purinergic nucleotide receptor activity;GO:0004931 extracellularly ATP-gated monoatomic cation channel activity;GO:0099604 ligand-gated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0045121 membrane raft;GO:0045211 postsynaptic membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0033198 response to ATP;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BIP1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BPU9-1", "uniprot_id": [ { "id": "E1BPU9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BPU9", "type": "external" } ], "mass": 165035.0, "length": 1468, "protein_name": "protein-tyrosine-phosphatase", "gene_name": "PTPRM", "organism": "Bovine", "refseq_name": "receptor-type tyrosine-protein phosphatase mu isoform X2", "refseq_ac": [ { "id": "XP_010817253", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817253", "type": "external" } ], "gene_names_uniprotkb": "PTPRM", "gene_names_refseq": "PTPRM", "protein_names_uniprotkb": "protein-tyrosine-phosphatase; 3.1.3.48", "protein_names_refseq": "receptor-type tyrosine-protein phosphatase mu isoform X2", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity;GO:0042802 identical protein binding;GO:0045296 cadherin binding;GO:0005001 transmembrane receptor protein tyrosine phosphatase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0030027 lamellipodium;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0031175 neuron projection development;GO:0001937 negative regulation of endothelial cell proliferation;GO:0016525 negative regulation of angiogenesis;GO:0010596 negative regulation of endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BPU9-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKT9-1", "uniprot_id": [ { "id": "E1BKT9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKT9", "type": "external" } ], "mass": 332408.0, "length": 2889, "protein_name": "Desmoplakin", "gene_name": "DSP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DSP", "gene_names_refseq": "", "protein_names_uniprotkb": "Desmoplakin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-351906); (R-BTA-6798695); (R-BTA-6805567); (R-BTA-6809371); (R-BTA-9696264); (R-BTA-9696273)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0005198 structural molecule activity;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0014704 intercalated disc;GO:0030057 desmosome", "go_biological_process": "GO:0045104 intermediate filament cytoskeleton organization;GO:0150105 protein localization to cell-cell junction;GO:0086091 regulation of heart rate by cardiac conduction;GO:0030216 keratinocyte differentiation;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BKT9-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MCQ5-1", "uniprot_id": [ { "id": "F1MCQ5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MCQ5", "type": "external" } ], "mass": 218408.0, "length": 1922, "protein_name": "Endoribonuclease Dicer", "gene_name": "DICER1", "organism": "Bovine", "refseq_name": "endoribonuclease Dicer", "refseq_ac": [ { "id": "NP_001421951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421951", "type": "external" } ], "gene_names_uniprotkb": "DICER1", "gene_names_refseq": "DICER1; Dicer", "protein_names_uniprotkb": "Endoribonuclease Dicer; 3.1.26.3", "protein_names_refseq": "Dicer1, Dcr-1 homolog; dicer 1, ribonuclease type III; endoribonuclease Dicer; ribonuclease III", "tax_id": 9913, "disease": "", "pathway": " (bta:337871); (R-BTA-203927); (R-BTA-426486)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21823189", "class_list": "", "function": "Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Studied Dicer gene expression during early bovine embryo development.An increase in Dicer expression was detected in the mature oocytes sampled (P<0.05), implying that gene repression occurs during meiosis II., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.26.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004386 helicase activity;GO:0004525 ribonuclease III activity;GO:0061980 regulatory RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016442 RISC complex;GO:0070578 RISC-loading complex;GO:0005634 nucleus", "go_biological_process": "GO:0031054 pre-miRNA processing;GO:0030422 siRNA processing;GO:0016441 post-transcriptional gene silencing;GO:0051239 regulation of multicellular organismal process;GO:0006309 apoptotic DNA fragmentation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MCQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9XT56-1", "uniprot_id": [ { "id": "JAM1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9XT56", "type": "external" } ], "mass": 32456.0, "length": 298, "protein_name": "Junctional adhesion molecule A", "gene_name": "F11R", "organism": "Bovine", "refseq_name": "junctional adhesion molecule A precursor", "refseq_ac": [ { "id": "NP_776520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776520", "type": "external" } ], "gene_names_uniprotkb": "F11R; JAM1", "gene_names_refseq": "F11R; JAM1", "protein_names_uniprotkb": "Junctional adhesion molecule A; JAM-1; JAM-A; Junctional adhesion molecule 1", "protein_names_refseq": "JAM-1; JAM-A; junctional adhesion molecule 1; junctional adhesion molecule A precursor; junctional adhesion molecule A", "tax_id": 9913, "disease": "", "pathway": " (bta:281258); (R-BTA-202733); (R-BTA-216083); (R-BTA-2173791); (R-BTA-420029)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "10395639;16305752", "class_list": "", "function": "Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5E9V8", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0042803 protein homodimerization activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0032991 protein-containing complex", "go_biological_process": "GO:0090559 regulation of membrane permeability;GO:0072659 protein localization to plasma membrane;GO:1903142 positive regulation of establishment of endothelial barrier;GO:0050892 intestinal absorption;GO:0007159 leukocyte cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9XT56-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T0Y3-1", "uniprot_id": [ { "id": "ST1B1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T0Y3", "type": "external" } ], "mass": 34674.0, "length": 296, "protein_name": "Sulfotransferase 1B1", "gene_name": "SULT1B1", "organism": "Bovine", "refseq_name": "sulfotransferase 1B1", "refseq_ac": [ { "id": "NP_001069291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069291", "type": "external" } ], "gene_names_uniprotkb": "SULT1B1", "gene_names_refseq": "ST1B1; SULT1B1", "protein_names_uniprotkb": "Sulfotransferase 1B1; 2.8.2.1; ST1B1; Sulfotransferase family cytosolic 1B member 1", "protein_names_refseq": "sulfotransferase 1B1; sulfotransferase family, cytosolic, 1B, member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:521920); (R-BTA-156584)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "25539458", "class_list": "", "function": "SULT1B1 seems to be a major form in both male and female bovine liver., [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine small phenols such as 1-naphthol and 4-nitrophenol (PubMed:25539458). Also catalyzes the sulfate conjugation of dopamine and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.4", "type": "external" }, { "id": "2.8.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.1", "type": "external" } ], "go_molecular_function": "GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0030855 epithelial cell differentiation;GO:0006068 ethanol catabolic process;GO:0006805 xenobiotic metabolic process;GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3T0Y3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNN6-1", "uniprot_id": [ { "id": "E1BNN6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNN6", "type": "external" } ], "mass": 159316.0, "length": 1410, "protein_name": "NLR family pyrin domain containing 1", "gene_name": "NLRP1", "organism": "Bovine", "refseq_name": "NACHT, LRR and PYD domains-containing protein 1 isoform X1", "refseq_ac": [ { "id": "XP_003587454", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587454", "type": "external" } ], "gene_names_uniprotkb": "NLRP1", "gene_names_refseq": "NLRP1", "protein_names_uniprotkb": "NLR family pyrin domain containing 1", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:528166); (R-BTA-844455)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005654 nucleoplasm;GO:0072558 NLRP1 inflammasome complex;GO:0072559 NLRP3 inflammasome complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0042981 regulation of apoptotic process;GO:0071493 cellular response to UV-B;GO:1904784 NLRP1 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BNN6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58CX9-1", "uniprot_id": [ { "id": "CBPC5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q58CX9", "type": "external" } ], "mass": 97441.0, "length": 885, "protein_name": "Cytosolic carboxypeptidase-like protein 5", "gene_name": "AGBL5", "organism": "Bovine", "refseq_name": "cytosolic carboxypeptidase-like protein 5", "refseq_ac": [ { "id": "NP_001019735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019735", "type": "external" } ], "gene_names_uniprotkb": "AGBL5; CCP5", "gene_names_refseq": "AGBL5", "protein_names_uniprotkb": "Cytosolic carboxypeptidase-like protein 5; 3.4.17.-; 3.4.17.24; ATP/GTP-binding protein-like 5; Protein deglutamylase CCP5", "protein_names_refseq": "ATP/GTP binding protein like 5; cytosolic carboxypeptidase-like protein 5; protein deglutamylase CCP5", "tax_id": 9913, "disease": "", "pathway": " (bta:538585)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1A4I0;E1B7H7", "ec_number_list": [ { "id": "3.4.17.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.24", "type": "external" }, { "id": "3.4.17.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0030496 midbody", "go_biological_process": "GO:0006508 proteolysis;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q58CX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Z4YHD9-1", "uniprot_id": [ { "id": "Z4YHD9_BOVIN", "url": "https://www.uniprot.org/uniprot/Z4YHD9", "type": "external" } ], "mass": 154800.0, "length": 1384, "protein_name": "Hepatocyte growth factor receptor", "gene_name": "MET", "organism": "Bovine", "refseq_name": "hepatocyte growth factor receptor isoform X1", "refseq_ac": [ { "id": "XP_024846175", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846175", "type": "external" } ], "gene_names_uniprotkb": "MET", "gene_names_refseq": "HGFR; MET; c-met", "protein_names_uniprotkb": "Hepatocyte growth factor receptor; 2.7.10.1; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; Tyrosine-protein kinase Met", "protein_names_refseq": "hepatocyte growth factor receptor isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1257604); (R-BTA-416550); (R-BTA-5673001); (R-BTA-6806942); (R-BTA-6807004); (R-BTA-6811558); (R-BTA-8851805); (R-BTA-8851907); (R-BTA-8865999); (R-BTA-8874081); (R-BTA-8875513); (R-BTA-8875555); (R-BTA-8875656); (R-BTA-8875791); (R-BTA-9734091)", "pathway_count": 15, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0017154 semaphorin receptor activity;GO:0042802 identical protein binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010468 regulation of gene expression;GO:0048468 cell development;GO:0048513 animal organ development;GO:2001028 positive regulation of endothelial cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Z4YHD9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCW3-1", "uniprot_id": [ { "id": "E1BCW3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCW3", "type": "external" } ], "mass": 97498.0, "length": 909, "protein_name": "ATP-dependent 6-phosphofructokinase", "gene_name": "PFKP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PFKP", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase; 2.7.1.11; ATP-PFK; Phosphofructokinase; Phosphohexokinase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-70171)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003872 6-phosphofructokinase activity;GO:0070095 fructose-6-phosphate binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005945 6-phosphofructokinase complex", "go_biological_process": "GO:0006002 fructose 6-phosphate metabolic process;GO:0030388 fructose 1,6-bisphosphate metabolic process;GO:0061621 canonical glycolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCW3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9BEG5-1", "uniprot_id": [ { "id": "EDA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9BEG5", "type": "external" } ], "mass": 41567.0, "length": 391, "protein_name": "Ectodysplasin-A", "gene_name": "EDA", "organism": "Bovine", "refseq_name": "ectodysplasin-A", "refseq_ac": [ { "id": "NP_001075212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075212", "type": "external" } ], "gene_names_uniprotkb": "EDA; ED1", "gene_names_refseq": "ED1; EDA", "protein_names_uniprotkb": "Ectodysplasin-A; Ectodermal dysplasia protein; Ectodysplasin-1", "protein_names_refseq": "Ectodysplasin 1; ectodermal dysplasia 1, anhidrotic; ectodermal dysplasia protein; ectodysplasin-1; ectodysplasin-A", "tax_id": 9913, "disease": "", "pathway": " (bta:616179); (R-BTA-5669034)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11167539;12021844;21410470;21740563;22034998;38252617", "class_list": "", "function": "A missense mutation in the highly conserved TNF-like domain of Ectodysplasin A is the candidate causative variant for X-linked hypohidrotic ectodermal dysplasia in Limousin cattle: Clinical, histological, and molecular analyses. Publication Status: Online-Only, [RefSeq, PubMed]; A single point mutation within this gene disrupts correct splicing at two different splice sites and leads to anhidrotic ectodermal dysplasia in cattle, [RefSeq, PubMed]; Authors identifya mutation, never described before, that changes the regulation of alternative splicing in the EDA gene and causes ectodermal dysplasia in cattle. Publication Status: Online-Only, [RefSeq, PubMed]; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion., [UniProtKB, UniProtKB, UniProtKB]; Describe a novel mutation of the EDA gene in which a 19 bp deletion in exon 1 in male Holstein calves demonstrated the phenotypic features of EDA, [RefSeq, PubMed]; Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R., [UniProtKB, UniProtKB]; Isoform A2 binds exclusively to the receptor EDA2R., [UniProtKB, UniProtKB]; The 161-bp-long LINE1-derived-pseudoexon introduces a shift in reading frame and a premature stop codon early in EDA exon 2 and is probably the cause of XHED in this Danish Red Holstein family., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9BEG6", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0038177 death receptor agonist activity;GO:0005123 death receptor binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045177 apical part of cell;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006955 immune response;GO:0030154 cell differentiation;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0042475 odontogenesis of dentin-containing tooth;GO:0042476 odontogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9BEG5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MM41-1", "uniprot_id": [ { "id": "ZNRF1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MM41", "type": "external" } ], "mass": 23712.0, "length": 227, "protein_name": "E3 ubiquitin-protein ligase ZNRF1", "gene_name": "ZNRF1", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase ZNRF1", "refseq_ac": [ { "id": "NP_001179139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179139", "type": "external" } ], "gene_names_uniprotkb": "ZNRF1", "gene_names_refseq": "ZNRF1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ZNRF1; 2.3.2.27; RING-type E3 ubiquitin transferase ZNRF1; Zinc/RING finger protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase ZNRF1; RING-type E3 ubiquitin transferase ZNRF1; zinc/RING finger protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:509076); (R-BTA-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation. Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery. Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production. Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0034145 positive regulation of toll-like receptor 4 signaling pathway;GO:0160177 positive regulation of autophagosome-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MM41-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5E9Y0-1", "uniprot_id": [ { "id": "CDK2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5E9Y0", "type": "external" } ], "mass": 33873.0, "length": 298, "protein_name": "Cyclin-dependent kinase 2", "gene_name": "CDK2", "organism": "Bovine", "refseq_name": "cyclin-dependent kinase 2", "refseq_ac": [ { "id": "NP_001014934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014934", "type": "external" } ], "gene_names_uniprotkb": "CDK2; CDKN2", "gene_names_refseq": "CDK2", "protein_names_uniprotkb": "Cyclin-dependent kinase 2; 2.7.11.22; Cell division protein kinase 2", "protein_names_refseq": "cell division protein kinase 2; cyclin-dependent kinase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:519217); (R-BTA-1538133); (R-BTA-171319); (R-BTA-176187); (R-BTA-176408); (R-BTA-187577); (R-BTA-2559582); (R-BTA-2559586); (R-BTA-5693607); (R-BTA-6804116); (R-BTA-6804756); (R-BTA-6804757); (R-BTA-68911); (R-BTA-68949); (R-BTA-68962); (R-BTA-69017); (R-BTA-69200); (R-BTA-69202); (R-BTA-69231); (R-BTA-69273); (R-BTA-69563); (R-BTA-69656); (R-BTA-8849470)", "pathway_count": 23, "publication_count": 2, "publication_id_list": "14967908;16305752", "class_list": "", "function": "Cyclin D1, CDK2 and CDK4 are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation, [RefSeq, PubMed]; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (By similarity). Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, SUV39H1, EZH2 (By similarity). Triggers duplication of centrosomes and DNA (By similarity). Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus (By similarity). Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs) (By similarity). Activated by the CDK-activating kinase (CAK) complex consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity (By similarity). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase (By similarity). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC (By similarity). Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis (By similarity). In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation (By similarity). Involved in regulation of telomere repair by mediating phosphorylation of NBN (By similarity). Phosphorylation of RB1 disturbs its interaction with E2F1 (By similarity). NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociation from unduplicated centrosomes, thus initiating centrosome duplication (By similarity). Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase (By similarity). Required for vitamin D-mediated growth inhibition by being itself inactivated (By similarity). Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner (By similarity). USP37 is activated by phosphorylation and thus triggers G1-S transition (By similarity). CTNNB1 phosphorylation regulates insulin internalization (By similarity). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (By similarity). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of the C-terminus of protein kinase B (PKB/AKT1 and PKB/AKT2), promoting its activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, 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"total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0050839 cell adhesion molecule binding;GO:0019960 C-X3-C chemokine binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0008305 integrin complex;GO:0009986 cell surface;GO:0034668 integrin alpha4-beta1 complex;GO:0034669 integrin alpha4-beta7 complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:1904646 cellular response to amyloid-beta;GO:0033631 cell-cell adhesion mediated by integrin", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEF6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJQ3-1", "uniprot_id": [ { "id": "E1BJQ3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJQ3", "type": "external" } ], "mass": 50666.0, "length": 464, "protein_name": "Interleukin-6 receptor subunit alpha", "gene_name": "IL6R", "organism": "Bovine", "refseq_name": "interleukin-6 receptor subunit alpha precursor", "refseq_ac": [ { "id": "NP_001104255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104255", "type": "external" } ], "gene_names_uniprotkb": "IL6R", "gene_names_refseq": "IL6R", "protein_names_uniprotkb": "Interleukin-6 receptor subunit alpha; IL-6R 1", "protein_names_refseq": "interleukin-6 receptor subunit alpha precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:507359); (R-BTA-1059683); (R-BTA-110056); (R-BTA-9958825)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "19790045;29353404", "class_list": "", "function": "Mechanical injury potentiates the catabolic effects of TNFalpha and IL-6/sIL-6R in causing proteoglycan degradation in human and bovine cartilage., [RefSeq, PubMed]; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory. Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases. In complex with IL6, is required for induction of VEGF production. Plays a protective role during liver injury, being required for maintenance of tissue regeneration. 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The DNA methylation level was high in mastitis-infected mammary gland tissues and stimulated IL6R expression, thereby promoting the inclusion of the alternatively spliced exon., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004896 cytokine receptor activity;GO:0004897 ciliary neurotrophic factor receptor activity;GO:0004915 interleukin-6 receptor activity;GO:0004921 interleukin-11 receptor activity;GO:0019970 interleukin-11 binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0070110 ciliary neurotrophic factor receptor complex;GO:0005896 interleukin-6 receptor complex;GO:0043235 receptor complex", "go_biological_process": "GO:0032502 developmental process;GO:0072126 positive regulation of glomerular mesangial cell proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0032722 positive regulation of chemokine production;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E1BJQ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4TVR5-1", "uniprot_id": [ { "id": "DUSTY_BOVIN", "url": "https://www.uniprot.org/uniprot/Q4TVR5", "type": "external" } ], "mass": 104804.0, "length": 928, "protein_name": "Dual serine/threonine and tyrosine protein kinase", "gene_name": "DSTYK", "organism": "Bovine", "refseq_name": "dual serine/threonine and tyrosine protein kinase", "refseq_ac": [ { "id": "NP_001019995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019995", "type": "external" } ], "gene_names_uniprotkb": "DSTYK; RIPK5", "gene_names_refseq": "DSTYK; RIPK5", "protein_names_uniprotkb": "Dual serine/threonine and tyrosine protein kinase; 2.7.12.1; Dusty PK; Dusty protein kinase; Receptor-interacting serine/threonine-protein kinase 5", "protein_names_refseq": "dual serine/threonine and tyrosine protein kinase; dusty PK; dusty protein kinase; receptor interacting protein kinase 5; receptor-interacting serine/threonine-protein kinase 5", "tax_id": 9913, "disease": "", "pathway": " (bta:534684)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17123648", "class_list": "", "function": "Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0033674 positive regulation of kinase activity;GO:0044344 cellular response to fibroblast growth factor stimulus;GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4TVR5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5E947-1", "uniprot_id": [ { "id": "PRDX1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5E947", "type": "external" } ], "mass": 22210.0, "length": 199, "protein_name": "Peroxiredoxin-1", "gene_name": "PRDX1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PRDX1", "gene_names_refseq": "", "protein_names_uniprotkb": "Peroxiredoxin-1; 1.11.1.24; Thioredoxin-dependent peroxiredoxin 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3000471); (R-BTA-3299685); (R-BTA-5628897); (R-BTA-9818027)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QLL7", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008379 thioredoxin peroxidase activity;GO:0140824 thioredoxin-dependent peroxiredoxin activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045454 cell redox homeostasis;GO:0019430 removal of superoxide radicals;GO:0042744 hydrogen peroxide catabolic process;GO:1901222 regulation of non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5E947-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BN47-1", "uniprot_id": [ { "id": "E1BN47_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BN47", "type": "external" } ], "mass": 145191.0, "length": 1253, "protein_name": "Cytoplasmic FMR1-interacting protein", "gene_name": "CYFIP1", "organism": "Bovine", "refseq_name": "cytoplasmic FMR1-interacting protein 1", "refseq_ac": [ { "id": "NP_001192444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192444", "type": "external" } ], "gene_names_uniprotkb": "CYFIP1", "gene_names_refseq": "CYFIP1; Sra-1; p140sra-1", "protein_names_uniprotkb": "Cytoplasmic FMR1-interacting protein", "protein_names_refseq": "Specifically Rac1-associated protein 1; cytoplasmic FMR1-interacting protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:100141021); (R-BTA-2029482); (R-BTA-5663213); (R-BTA-6798695); (R-BTA-9013404); (R-BTA-9013408); (R-BTA-9013423)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0030371 translation repressor activity;GO:0000340 RNA 7-methylguanosine cap binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030027 lamellipodium;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm;GO:0098794 postsynapse", "go_biological_process": "GO:0030833 regulation of actin filament polymerization;GO:0006417 regulation of translation;GO:0050890 cognition;GO:0000902 cell morphogenesis;GO:0016601 Rac protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BN47-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4A1L4-1", "uniprot_id": [ { "id": "BECN1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q4A1L4", "type": "external" } ], "mass": 51581.0, "length": 448, "protein_name": "Beclin-1", "gene_name": "BECN1", "organism": "Bovine", "refseq_name": "beclin-1", "refseq_ac": [ { "id": "NP_001028799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028799", "type": "external" } ], "gene_names_uniprotkb": "BECN1", "gene_names_refseq": "ATG6; BECN1", "protein_names_uniprotkb": "Beclin-1", "protein_names_refseq": "beclin 1, autophagy related; beclin-1; coiled-coil myosin-like BCL2-interacting protein", "tax_id": 9913, "disease": "", "pathway": " (bta:527278); (R-BTA-1169408); (R-BTA-1632852); (R-BTA-5689880)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a central role in autophagy. Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0043548 phosphatidylinositol 3-kinase binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0051301 cell division;GO:0051607 defense response to virus;GO:0006915 apoptotic process;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4A1L4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BAK9-1", "uniprot_id": [ { "id": "E1BAK9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BAK9", "type": "external" } ], "mass": 67099.0, "length": 611, "protein_name": "E3 ubiquitin-protein ligase synoviolin", "gene_name": "SYVN1", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase synoviolin isoform X1", "refseq_ac": [ { "id": "XP_024842812", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842812", "type": "external" } ], "gene_names_uniprotkb": "SYVN1", "gene_names_refseq": "SYVN1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase synoviolin; 2.3.2.27; RING-type E3 ubiquitin transferase synoviolin; Synovial apoptosis inhibitor 1", "protein_names_refseq": "E3 ubiquitin-protein ligase synoviolin isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5358346)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0044322 endoplasmic reticulum quality control compartment;GO:0005654 nucleoplasm;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BAK9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BG59-1", "uniprot_id": [ { "id": "E1BG59_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BG59", "type": "external" } ], "mass": 90483.0, "length": 797, "protein_name": "RAS guanyl-releasing protein 1", "gene_name": "RASGRP1", "organism": "Bovine", "refseq_name": "RAS guanyl-releasing protein 1", "refseq_ac": [ { "id": "NP_001137550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137550", "type": "external" } ], "gene_names_uniprotkb": "RASGRP1", "gene_names_refseq": "RASGRP1", "protein_names_uniprotkb": "RAS guanyl-releasing protein 1; Calcium and DAG-regulated guanine nucleotide exchange factor II; Ras guanyl-releasing protein", "protein_names_refseq": "RAS guanyl releasing protein 1 (calcium and DAG-regulated); RAS guanyl-releasing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:533125); (R-BTA-1169092); (R-BTA-354192); (R-BTA-392517); (R-BTA-5673001)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "26154292;32830401", "class_list": "", "function": "A mutation in RASGRP1 is associated with hereditary thrombopathia in polled German Fleckvieh cattle, [RefSeq, PubMed]; Novel tumour suppressor roles for GZMA and RASGRP1 in Theileria annulata-transformed macrophages and human B lymphoma cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0042802 identical protein binding;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0007264 small GTPase-mediated signal transduction;GO:1902531 regulation of intracellular signal transduction;GO:0002684 positive regulation of immune system process;GO:0045321 leukocyte activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E1BG59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95115-1", "uniprot_id": [ { "id": "STA5A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q95115", "type": "external" } ], "mass": 90700.0, "length": 794, "protein_name": "Signal transducer and activator of transcription 5A", "gene_name": "STAT5A", "organism": "Bovine", "refseq_name": "signal transducer and activator of transcription 5A", "refseq_ac": [ { "id": "NP_001012691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012691", "type": "external" } ], "gene_names_uniprotkb": "STAT5A; MGF", "gene_names_refseq": "STAT5A/MGF; STAT5A; STATA5", "protein_names_uniprotkb": "Signal transducer and activator of transcription 5A; Mammary gland factor", "protein_names_refseq": "STAT5A, Mammary Gland Factor; mammary gland factor; signal transducer and activator of transcription 5A; signal transducer and activator of transcription factor 5A", "tax_id": 9913, "disease": "", "pathway": " (bta:282375); (R-BTA-1251985); (R-BTA-1266695); (R-BTA-1433557); (R-BTA-186763); (R-BTA-512988); (R-BTA-8854691); (R-BTA-8983432); (R-BTA-8985947); (R-BTA-9020558); (R-BTA-9020958)", "pathway_count": 11, "publication_count": 8, "publication_id_list": "10442998;10835485;26845856;27865414;27885437;31785637;38086453;9589597", "class_list": "", "function": "Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity)., [UniProtKB]; INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS, [RefSeq, PubMed]; Impact of STAT5A-CNVs on growth traits in Chinese beef cattle breeds., [RefSeq, PubMed]; Milk production traits were analyzed for each animal in the first, second, third, and fourth lactation. No genetic variability was found at STAT5A/AvaI locus. At STAT5A/MslI locus, the frequencies of T and C alleles were 0.875 and 0.125, respectively. Significant differences between genotypes were found, [RefSeq, PubMed]; There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system., [RefSeq, PubMed]; This study showed that the IGF-1 SnaBI TT appears to be associated with fewer days to ovulation and lesser calving to conseption interval of lactating dairy cows and had an additive association with the GHR AluI T allele on indicators for improvement of fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O46628;O97606;Q9N0U8;Q9TUM1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity;GO:0042301 phosphate ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0046543 development of secondary female sexual characteristics;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006952 defense response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q95115-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJG5-1", "uniprot_id": [ { "id": "E1BJG5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJG5", "type": "external" } ], "mass": 88861.0, "length": 838, "protein_name": "Transcription intermediary factor 1-beta", "gene_name": "TRIM28", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TRIM28", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription intermediary factor 1-beta; 2.3.2.27; E3 SUMO-protein ligase TRIM28; RING-type E3 ubiquitin transferase TIF1-beta; Tripartite motif-containing protein 28", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-212436); (R-BTA-3899300); (R-BTA-9843940)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0061630 ubiquitin protein ligase activity;GO:0019789 SUMO transferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0032991 protein-containing complex;GO:0000791 euchromatin;GO:0090575 RNA polymerase II transcription regulator complex;GO:0000792 heterochromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045087 innate immune response;GO:0006346 DNA methylation-dependent constitutive heterochromatin formation;GO:0010604 positive regulation of macromolecule metabolic process;GO:0042307 positive regulation of protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BJG5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BBE1-1", "uniprot_id": [ { "id": "E1BBE1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BBE1", "type": "external" } ], "mass": 30046.0, "length": 273, "protein_name": "NK2 homeobox 2", "gene_name": "NKX2-2", "organism": "Bovine", "refseq_name": "homeobox protein Nkx-2.2", "refseq_ac": [ { "id": "NP_001179638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179638", "type": "external" } ], "gene_names_uniprotkb": "NKX2-2", "gene_names_refseq": "NKX2-2", "protein_names_uniprotkb": "NK2 homeobox 2", "protein_names_refseq": "homeobox protein Nkx-2.2", "tax_id": 9913, "disease": "", "pathway": " (bta:531695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BBE1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZD1-1", "uniprot_id": [ { "id": "PEX19_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZD1", "type": "external" } ], "mass": 32667.0, "length": 299, "protein_name": "Peroxisomal biogenesis factor 19", "gene_name": "PEX19", "organism": "Bovine", "refseq_name": "peroxisomal biogenesis factor 19", "refseq_ac": [ { "id": "NP_001029712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029712", "type": "external" } ], "gene_names_uniprotkb": "PEX19; PXF", "gene_names_refseq": "PEX19", "protein_names_uniprotkb": "Peroxisomal biogenesis factor 19; Peroxin-19; Peroxisomal farnesylated protein", "protein_names_refseq": "peroxin-19; peroxisomal biogenesis factor 19; peroxisomal farnesylated protein", "tax_id": 9913, "disease": "", "pathway": " (bta:521522); (R-BTA-1369062); (R-BTA-9603798)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036105 peroxisome membrane class-1 targeting sequence binding;GO:0033328 peroxisome membrane targeting sequence binding;GO:0051117 ATPase binding;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005778 peroxisomal membrane;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0016559 peroxisome fission;GO:0007031 peroxisome organization;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0006625 protein targeting to peroxisome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZD1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BC64-1", "uniprot_id": [ { "id": "E1BC64_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BC64", "type": "external" } ], "mass": 72584.0, "length": 647, "protein_name": "LIM domain kinase 1", "gene_name": "LIMK1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LIMK1", "gene_names_refseq": "", "protein_names_uniprotkb": "LIM domain kinase 1; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2029482); (R-BTA-399954); (R-BTA-5627123)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0051496 positive regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BC64-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EA42-1", "uniprot_id": [ { "id": "ABHD2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5EA42", "type": "external" } ], "mass": 48252.0, "length": 425, "protein_name": "Monoacylglycerol lipase ABHD2", "gene_name": "ABHD2", "organism": "Bovine", "refseq_name": "monoacylglycerol lipase ABHD2", "refseq_ac": [ { "id": "NP_001015549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015549", "type": "external" } ], "gene_names_uniprotkb": "ABHD2", "gene_names_refseq": "ABHD2", "protein_names_uniprotkb": "Monoacylglycerol lipase ABHD2; 2-arachidonoylglycerol hydrolase; 3.1.1.23; 3.1.1.6; 3.1.1.79; Abhydrolase domain-containing protein 2; Acetylesterase; Triacylglycerol lipase", "protein_names_refseq": "2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 2; acetylesterase; monoacylglycerol lipase ABHD2; triacylglycerol lipase", "tax_id": 9913, "disease": "", "pathway": " (bta:508717)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). May also play a role in smooth muscle cells migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6H753", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0003707 nuclear steroid receptor activity;GO:0042562 hormone binding;GO:0004806 triacylglycerol lipase activity;GO:0008126 acetylesterase activity", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0097524 sperm plasma membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0030336 negative regulation of cell migration;GO:0046464 acylglycerol catabolic process;GO:0009611 response to wounding;GO:0032570 response to progesterone;GO:0043401 steroid hormone receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5EA42-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHX4-1", "uniprot_id": [ { "id": "F1MHX4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHX4", "type": "external" } ], "mass": 51162.0, "length": 451, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-2", "gene_name": "GABRA2", "organism": "Bovine", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-2 isoform X1", "refseq_ac": [ { "id": "XP_024848787", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848787", "type": "external" } ], "gene_names_uniprotkb": "GABRA2", "gene_names_refseq": "GABRA2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-2; GABA(A) receptor subunit alpha-2", "protein_names_refseq": "gamma-aminobutyric acid receptor subunit alpha-2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-977443)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0008503 benzodiazepine receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1904862 inhibitory synapse assembly;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHX4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58DM4-1", "uniprot_id": [ { "id": "ALKB2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q58DM4", "type": "external" } ], "mass": 31053.0, "length": 278, "protein_name": "DNA oxidative demethylase ALKBH2", "gene_name": "ALKBH2", "organism": "Bovine", "refseq_name": "DNA oxidative demethylase ALKBH2", "refseq_ac": [ { "id": "NP_001019687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019687", "type": "external" } ], "gene_names_uniprotkb": "ALKBH2; ABH2", "gene_names_refseq": "ALKBH2", "protein_names_uniprotkb": "DNA oxidative demethylase ALKBH2; 1.14.11.33; Alkylated DNA repair protein alkB homolog 2; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2", "protein_names_refseq": "DNA oxidative demethylase ALKBH2; alkB, alkylation repair homolog 2; alkylated DNA repair protein alkB homolog 2; alpha-ketoglutarate-dependent dioxygenase alkB homolog 2", "tax_id": 9913, "disease": "", "pathway": " (bta:511380)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Dioxygenase that repairs alkylated nucleic acid bases by direct reversal oxidative dealkylation. Can process both double-stranded (ds) and single-stranded (ss) DNA substrates, with a strong preference for dsDNA (By similarity). Uses molecular oxygen, 2-oxoglutarate and iron as cofactors to oxidize the alkyl groups that are subsequently released as aldehydes, regenerating the undamaged bases. Probes the base pair stability, locates a weakened base pair and flips the damaged base to accommodate the lesion in its active site for efficient catalysis (By similarity). Repairs monoalkylated bases, specifically N1-methyladenine and N3-methylcytosine, as well as higher order alkyl adducts such as bases modified with exocyclic bridged adducts known as etheno adducts including 1,N6-ethenoadenine, 3,N4-ethenocytosine and 1,N2-ethenoguanine (By similarity). Acts as a gatekeeper of genomic integrity under alkylation stress. Efficiently repairs alkylated lesions in ribosomal DNA (rDNA). These lesions can cause ss- and dsDNA strand breaks that severely impair rDNA transcription (By similarity). In a response mechanism to DNA damage, associates with PCNA at replication forks to repair alkylated adducts prior to replication (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VCG6", "ec_number_list": [ { "id": "1.14.11.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "1.14.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33", "type": "external" }, { "id": "1.14.11.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.54", "type": "external" } ], "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0051747 cytosine C-5 DNA demethylase activity;GO:0000182 rDNA binding;GO:0035516 broad specificity oxidative DNA demethylase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006307 DNA alkylation repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q58DM4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58CN8-1", "uniprot_id": [ { "id": "SESN2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q58CN8", "type": "external" } ], "mass": 53600.0, "length": 471, "protein_name": "Sestrin-2", "gene_name": "SESN2", "organism": "Bovine", "refseq_name": "sestrin-2", "refseq_ac": [ { "id": "NP_001019678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019678", "type": "external" } ], "gene_names_uniprotkb": "SESN2", "gene_names_refseq": "SESN2", "protein_names_uniprotkb": "Sestrin-2; 1.11.1.-", "protein_names_refseq": "sestrin-2", "tax_id": 9913, "disease": "", "pathway": " (bta:509863); (R-BTA-5628897); (R-BTA-9639288); (R-BTA-9755511)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "16305752;30969118", "class_list": "", "function": "Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed., [UniProtKB, UniProtKB]; SESN2 negatively regulates the mTORC1 pathway and subsequent CSN2 synthesis through the SH3BP4 in response to amino acids depletion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08E69", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0016684 oxidoreductase activity, acting on peroxide as acceptor;GO:0004601 peroxidase activity;GO:0070728 L-leucine binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990316 Atg1/ULK1 kinase complex;GO:0005765 lysosomal membrane;GO:0031588 nucleotide-activated protein kinase complex", "go_biological_process": "GO:0030308 negative regulation of cell growth;GO:0034599 cellular response to oxidative stress;GO:0016239 positive regulation of macroautophagy;GO:0072593 reactive oxygen species metabolic process;GO:0001932 regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q58CN8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BFC8-1", "uniprot_id": [ { "id": "E1BFC8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BFC8", "type": "external" } ], "mass": 82963.0, "length": 752, "protein_name": "Lysyl oxidase homolog", "gene_name": "LOXL3", "organism": "Bovine", "refseq_name": "lysyl oxidase homolog 3 precursor", "refseq_ac": [ { "id": "NP_001179898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179898", "type": "external" } ], "gene_names_uniprotkb": "LOXL3", "gene_names_refseq": "LOXL3", "protein_names_uniprotkb": "Lysyl oxidase homolog; 1.4.3.13", "protein_names_refseq": "lysyl oxidase homolog 3 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:613599); (R-BTA-1566948); (R-BTA-2243919)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" } ], "go_molecular_function": "GO:0005507 copper ion binding;GO:0004720 protein-lysine 6-oxidase activity;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006954 inflammatory response;GO:0021510 spinal cord development;GO:0030324 lung development;GO:0045892 negative regulation of DNA-templated transcription;GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BFC8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9BDR7-1", "uniprot_id": [ { "id": "FCERG_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9BDR7", "type": "external" } ], "mass": 9463.0, "length": 85, "protein_name": "High affinity immunoglobulin epsilon receptor subunit gamma", "gene_name": "FCER1G", "organism": "Bovine", "refseq_name": "high affinity immunoglobulin epsilon receptor subunit gamma precursor", "refseq_ac": [ { "id": "NP_776962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776962", "type": "external" } ], "gene_names_uniprotkb": "FCER1G", "gene_names_refseq": "FCER1G", "protein_names_uniprotkb": "High affinity immunoglobulin epsilon receptor subunit gamma; Fc receptor gamma-chain; Fc-epsilon RI-gamma; FcRgamma; FceRI gamma; IgE Fc receptor subunit gamma", "protein_names_refseq": "Fc fragment of IgE receptor Ig; Fc fragment of IgE, high affinity I, receptor for; Fc receptor gamma-chain; fc-epsilon RI-gamma; fcRgamma; fceRI gamma; gamma polypeptide; high affinity immunoglobulin epsilon receptor subunit gamma precursor; high affinity immunoglobulin epsilon receptor subunit gamma; igE Fc receptor subunit gamma", "tax_id": 9913, "disease": "", "pathway": " (bta:282226); (R-BTA-114604); (R-BTA-2454202); (R-BTA-2730905); (R-BTA-2871796); (R-BTA-2871809); (R-BTA-2871837); (R-BTA-5621480); (R-BTA-6798695); (R-BTA-75892)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "11557297", "class_list": "", "function": "Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZX3", "ec_number_list": [], "go_molecular_function": "GO:0019767 IgE receptor activity;GO:0019863 IgE binding;GO:0042803 protein homodimerization activity;GO:0019864 IgG binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0032998 Fc-epsilon receptor I complex;GO:0033001 Fc-gamma receptor III complex", "go_biological_process": "GO:0002292 T cell differentiation involved in immune response;GO:0038094 Fc-gamma receptor signaling pathway;GO:0002283 neutrophil activation involved in immune response;GO:0002431 Fc receptor mediated stimulatory signaling pathway;GO:0002554 serotonin secretion by platelet", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9BDR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5W9D7-1", "uniprot_id": [ { "id": "QKI_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5W9D7", "type": "external" } ], "mass": 37671.0, "length": 341, "protein_name": "KH domain-containing RNA-binding protein QKI", "gene_name": "QKI", "organism": "Bovine", "refseq_name": "KH domain-containing RNA-binding protein QKI", "refseq_ac": [ { "id": "NP_001007818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007818", "type": "external" } ], "gene_names_uniprotkb": "QKI", "gene_names_refseq": "BqkI; QKI", "protein_names_uniprotkb": "KH domain-containing RNA-binding protein QKI; BqkI; Protein quaking", "protein_names_refseq": "KH domain-containing RNA-binding protein QKI; protein quaking; quaking homolog, KH domain RNA binding; quaking protein", "tax_id": 9913, "disease": "", "pathway": " (bta:493722)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16147890", "class_list": "", "function": "Complementary DNA (cDNA) for bovine quaking gene (Bqk), equine quaking gene (Eqk) and porcine quaking gene (Pqk), which are homologous to mouse quaking gene (qkI), were isolated, and their nucleotide sequences were determined., [RefSeq, PubMed]; RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularization of pre-mRNAs. Plays a central role in myelinization via 3 distinct mechanisms (By similarity). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation. Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA. Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation. Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (By similarity). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (By similarity). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts. Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1. Also required for visceral endoderm function and blood vessel development (By similarity). May also play a role in smooth muscle development (By similarity). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0017124 SH3 domain binding;GO:0035198 miRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0045202 synapse", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0035886 vascular associated smooth muscle cell differentiation;GO:0048255 mRNA stabilization;GO:0017148 negative regulation of translation;GO:0045650 negative regulation of macrophage differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5W9D7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BHR8-1", "uniprot_id": [ { "id": "E1BHR8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BHR8", "type": "external" } ], "mass": 224253.0, "length": 1981, "protein_name": "Sodium channel protein", "gene_name": "SCN2A; SCN3A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SCN2A; SCN3A; SCN3A", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium channel protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5576892)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1BMH1;E1BNL5;E1BPF1", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0001518 voltage-gated sodium channel complex;GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:0035725 sodium ion transmembrane transport;GO:0086002 cardiac muscle cell action potential involved in contraction;GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BHR8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q59A32-1", "uniprot_id": [ { "id": "PUR2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q59A32", "type": "external" } ], "mass": 107907.0, "length": 1010, "protein_name": "Trifunctional purine biosynthetic protein adenosine-3", "gene_name": "GART", "organism": "Bovine", "refseq_name": "trifunctional purine biosynthetic protein adenosine-3", "refseq_ac": [ { "id": "NP_001035563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035563", "type": "external" } ], "gene_names_uniprotkb": "GART", "gene_names_refseq": "GART", "protein_names_uniprotkb": "Trifunctional purine biosynthetic protein adenosine-3; 5'-phosphoribosylglycinamide transformylase; AIR synthase; AIRS; GAR transformylase; GARS; GART; Glycinamide ribonucleotide synthetase; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylglycinamide synthetase", "protein_names_refseq": "glycinamide ribonucleotide synthetase; phosphoribosylglycinamide synthetase; trifunctional purine biosynthetic protein adenosine-3", "tax_id": 9913, "disease": "", "pathway": " (bta:281183); (R-BTA-73817)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15777723;23762392", "class_list": "", "function": "Three novel mutations with very damaging effect on the protein structure, according to SIFT and Polyphen-2, were detected in GART, SHBG and SLC37A2 genes. Publication Status: Online-Only, [RefSeq, PubMed]; Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.2", "type": "external" }, { "id": "6.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.3.1", "type": "external" }, { "id": "6.3.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.13", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004637 phosphoribosylamine-glycine ligase activity;GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity;GO:0004644 phosphoribosylglycinamide formyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006177 GMP biosynthetic process;GO:0006164 purine nucleotide biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process;GO:0044208 'de novo' AMP biosynthetic process;GO:0046084 adenine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q59A32-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5E9B7-1", "uniprot_id": [ { "id": "CLIC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5E9B7", "type": "external" } ], "mass": 26992.0, "length": 241, "protein_name": "Chloride intracellular channel protein 1", "gene_name": "CLIC1", "organism": "Bovine", "refseq_name": "chloride intracellular channel protein 1", "refseq_ac": [ { "id": "NP_001015608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015608", "type": "external" } ], "gene_names_uniprotkb": "CLIC1", "gene_names_refseq": "CLIC1", "protein_names_uniprotkb": "Chloride intracellular channel protein 1; 1.8.-.-; 1.8.5.1; Glutaredoxin-like oxidoreductase CLIC1; Glutathione-dependent dehydroascorbate reductase CLIC1", "protein_names_refseq": "chloride intracellular channel protein 1; glutaredoxin-like oxidoreductase CLIC1; glutathione-dependent dehydroascorbate reductase CLIC1", "tax_id": 9913, "disease": "", "pathway": " (bta:515646)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (By similarity). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0045174 glutathione dehydrogenase (ascorbate) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5E9B7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZ79-1", "uniprot_id": [ { "id": "LIPC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZ79", "type": "external" } ], "mass": 56826.0, "length": 500, "protein_name": "Hepatic triacylglycerol lipase", "gene_name": "LIPC", "organism": "Bovine", "refseq_name": "hepatic triacylglycerol lipase precursor", "refseq_ac": [ { "id": "NP_001030487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030487", "type": "external" } ], "gene_names_uniprotkb": "LIPC", "gene_names_refseq": "LIPC", "protein_names_uniprotkb": "Hepatic triacylglycerol lipase; 3.1.1.32; 3.1.1.3; 3.1.1.5; HL; Hepatic lipase; Lipase member C; Lysophospholipase; Phospholipase A1", "protein_names_refseq": "HL; hepatic lipase; hepatic triacylglycerol lipase precursor; hepatic triacylglycerol lipase; lipase member C; lipase, hepatic; lysophospholipase; phospholipase A1", "tax_id": 9913, "disease": "", "pathway": " (bta:535192); (R-BTA-8963889); (R-BTA-8964026)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (By similarity). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.19", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0008201 heparin binding;GO:0034185 apolipoprotein binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008970 phospholipase A1 activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0034374 low-density lipoprotein particle remodeling;GO:0034375 high-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SZ79-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZJ2-1", "uniprot_id": [ { "id": "RIPK2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZJ2", "type": "external" } ], "mass": 61106.0, "length": 540, "protein_name": "Receptor-interacting serine/threonine-protein kinase 2", "gene_name": "RIPK2", "organism": "Bovine", "refseq_name": "receptor-interacting serine/threonine-protein kinase 2", "refseq_ac": [ { "id": "NP_001029782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029782", "type": "external" } ], "gene_names_uniprotkb": "RIPK2", "gene_names_refseq": "RIPK2", "protein_names_uniprotkb": "Receptor-interacting serine/threonine-protein kinase 2; 2.7.10.2; 2.7.11.1; Tyrosine-protein kinase RIPK2", "protein_names_refseq": "receptor-interacting serine/threonine-protein kinase 2; tyrosine-protein kinase RIPK2", "tax_id": 9913, "disease": "", "pathway": " (bta:534407); (R-BTA-168638); (R-BTA-202424); (R-BTA-209543); (R-BTA-450302); (R-BTA-450321); (R-BTA-5689896)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "16485369;22314416;30941762", "class_list": "", "function": "Both iE-DAP and LPS highly increased the expression of both NOD1 and RIPK2, the two key factors for the immune response in hepatocytes., [RefSeq, PubMed]; Genetic mapping of RIPK2 in cattle., [RefSeq, PubMed]; SNPs and haplotypes from RIPK2 were associated with tick burden in both dairy and beef cattle., [RefSeq, PubMed]; Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors. 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process. 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2. Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. Plays a role in the inactivation of RHOA in response to NGFR signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3SZJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZB4-1", "uniprot_id": [ { "id": "ACADM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZB4", "type": "external" } ], "mass": 46573.0, "length": 421, "protein_name": "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "ACADM", "organism": "Bovine", "refseq_name": "medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001068703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068703", "type": "external" } ], "gene_names_uniprotkb": "ACADM", "gene_names_refseq": "ACADM", "protein_names_uniprotkb": "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.7; MCAD", "protein_names_refseq": "C-4 to C-12 straight chain acyl-coenzyme A dehydrogenase; MCAD; acyl-CoA dehydrogenase, C-4 to C-12 straight chain; acyl-coenzyme A dehydrogenase, C-4 to C-12 straight chain; medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor; medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:505968); (R-BTA-77288); (R-BTA-77346); (R-BTA-77348)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "27918674", "class_list": "", "function": "ACADM and ALDH2 were predicted to be the target genes of miR-224, [RefSeq, PubMed]; Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). ETF is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase has preference for fatty acyl-CoAs with saturated 6 to 12 carbons long primary chains, making it but can also catalyze longer chains such as C14 and C16., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7LFV4", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.9", "type": "external" }, { "id": "1.3.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.4", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0050660 flavin adenine dinucleotide binding;GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030424 axon;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0051793 medium-chain fatty acid catabolic process;GO:0051791 medium-chain fatty acid metabolic process;GO:0019254 carnitine metabolic process, CoA-linked", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SZB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MNI4-1", "uniprot_id": [ { "id": "F1MNI4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MNI4", "type": "external" } ], "mass": 23721.0, "length": 215, "protein_name": "small monomeric GTPase", "gene_name": "RAB5B", "organism": "Bovine", "refseq_name": "ras-related protein Rab-5B", "refseq_ac": [ { "id": "NP_001193120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193120", "type": "external" } ], "gene_names_uniprotkb": "RAB5B", "gene_names_refseq": "RAB5B", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-5B", "tax_id": 9913, "disease": "", "pathway": " (bta:539150); (R-BTA-6798695); (R-BTA-8856828); (R-BTA-8873719); (R-BTA-8876198)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030742 GTP-dependent protein binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0012505 endomembrane system;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0016197 endosomal transport;GO:0019882 antigen processing and presentation;GO:0048227 plasma membrane to endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MNI4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LP4-1", "uniprot_id": [ { "id": "S4A10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LP4", "type": "external" } ], "mass": 125776.0, "length": 1117, "protein_name": "Sodium-driven chloride bicarbonate exchanger", "gene_name": "SLC4A10", "organism": "Bovine", "refseq_name": "sodium-driven chloride bicarbonate exchanger", "refseq_ac": [ { "id": "NP_001033217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033217", "type": "external" } ], "gene_names_uniprotkb": "SLC4A10", "gene_names_refseq": "SLC4A10", "protein_names_uniprotkb": "Sodium-driven chloride bicarbonate exchanger; Solute carrier family 4 member 10", "protein_names_refseq": "sodium-driven chloride bicarbonate exchanger; solute carrier family 4, sodium bicarbonate transporter-like, member 10", "tax_id": 9913, "disease": "", "pathway": " (bta:517077); (R-BTA-425381)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (By similarity). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0008510 sodium:bicarbonate symporter activity;GO:0015293 symporter activity;GO:0015081 sodium ion transmembrane transporter activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0055085 transmembrane transport;GO:0007601 visual perception;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32LP4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MDA1-1", "uniprot_id": [ { "id": "F1MDA1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MDA1", "type": "external" } ], "mass": 99786.0, "length": 894, "protein_name": "Microsomal triglyceride transfer protein large subunit", "gene_name": "MTTP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MTTP", "gene_names_refseq": "", "protein_names_uniprotkb": "Microsomal triglyceride transfer protein large subunit", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8866423); (R-BTA-8963888); (R-BTA-8964041)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:1904121 phosphatidylethanolamine transfer activity;GO:0120020 cholesterol transfer activity;GO:0140344 triglyceride transfer activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0042157 lipoprotein metabolic process;GO:0042632 cholesterol homeostasis;GO:0007623 circadian rhythm;GO:0009306 protein secretion;GO:0034197 triglyceride transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MDA1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCZ6-1", "uniprot_id": [ { "id": "E1BCZ6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCZ6", "type": "external" } ], "mass": 146802.0, "length": 1352, "protein_name": "Macrophage-stimulating protein receptor", "gene_name": "MST1R", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MST1R", "gene_names_refseq": "", "protein_names_uniprotkb": "Macrophage-stimulating protein receptor; 2.7.10.1; p185-Ron", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:525504); (R-BTA-8852405)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001725 stress fiber;GO:0005773 vacuole;GO:0043235 receptor complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0009615 response to virus;GO:0007399 nervous system development;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCZ6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95L14-1", "uniprot_id": [ { "id": "PTGES_BOVIN", "url": "https://www.uniprot.org/uniprot/Q95L14", "type": "external" } ], "mass": 17298.0, "length": 153, "protein_name": "Prostaglandin E synthase", "gene_name": "PTGES", "organism": "Bovine", "refseq_name": "prostaglandin E synthase", "refseq_ac": [ { "id": "NP_776868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776868", "type": "external" } ], "gene_names_uniprotkb": "PTGES", "gene_names_refseq": "MPGES-1; PTGES", "protein_names_uniprotkb": "Prostaglandin E synthase; 1.11.1.-; 2.5.1.18; 5.3.99.3; Glutathione peroxidase PTGES; Glutathione transferase PTGES; MPGES-1; Microsomal prostaglandin E synthase 1", "protein_names_refseq": "glutathione peroxidase PTGES; glutathione transferase PTGES; microsomal prostaglandin E synthase 1; prostaglandin E synthase", "tax_id": 9913, "disease": "", "pathway": " (bta:282019); (R-BTA-2162123)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11448962;12080013;12664594;23704311;24856470;25412999;28244342", "class_list": "", "function": "Activity and purification of this membrane-bound protein from the heart, [RefSeq, PubMed]; Data suggest that elevated temperatures stimulate PGE2 production in ampullary oviduct by increasing expression of PGES and HSP90AA1 (heat shock 90 kD protein 1 alpha). Publication Status: Online-Only, [RefSeq, PubMed]; Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle., [RefSeq, PubMed]; PGES pathway is responsible for the endometrial production of PGE(2) in the bovine endometrium during the estrous cycle, [RefSeq, PubMed]; Prostaglandin E synthase interacts with inducible heat shock protein 70 after heat stress in bovine primary dermal fibroblast cells., [RefSeq, PubMed]; Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli. Plays a key role in inflammation response, fever and pain. Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5C8", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0050220 prostaglandin-E synthase activity;GO:0004602 glutathione peroxidase activity;GO:0004667 prostaglandin-D synthase activity", "go_cellular_component": "GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005641 nuclear envelope lumen;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050727 regulation of inflammatory response;GO:0071347 cellular response to interleukin-1;GO:0001516 prostaglandin biosynthetic process;GO:0031620 regulation of fever generation;GO:0019233 sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q95L14-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9XSC3-1", "uniprot_id": [ { "id": "WDR44_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9XSC3", "type": "external" } ], "mass": 101293.0, "length": 912, "protein_name": "WD repeat-containing protein 44", "gene_name": "WDR44", "organism": "Bovine", "refseq_name": "WD repeat-containing protein 44", "refseq_ac": [ { "id": "NP_777199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777199", "type": "external" } ], "gene_names_uniprotkb": "WDR44; RAB11BP; RPH11", "gene_names_refseq": "Rab11BP; WDR44", "protein_names_uniprotkb": "WD repeat-containing protein 44; Rab11-binding protein; Rab11BP; Rabphilin-11", "protein_names_refseq": "WD repeat-containing protein 44; rab11 binding protein; rabphilin-11", "tax_id": 9913, "disease": "", "pathway": " (bta:286825)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10077598", "class_list": "", "function": "Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:10077598). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:10077598). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (By similarity). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0010008 endosome membrane", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0060627 regulation of vesicle-mediated transport;GO:0061824 cytosolic ciliogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9XSC3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76LV1-1", "uniprot_id": [ { "id": "HS90B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q76LV1", "type": "external" } ], "mass": 83253.0, "length": 724, "protein_name": "Heat shock protein HSP 90-beta", "gene_name": "HSP90AB1", "organism": "Bovine", "refseq_name": "heat shock protein HSP 90-beta", "refseq_ac": [ { "id": "NP_001073105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073105", "type": "external" } ], "gene_names_uniprotkb": "HSP90AB1; HSPC3; HSPCB", "gene_names_refseq": "HSP90AB1; HSPCB", "protein_names_uniprotkb": "Heat shock protein HSP 90-beta", "protein_names_refseq": "heat shock 90 kDa protein; heat shock 90kDa protein 1, beta; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein HSP 90-beta", "tax_id": 9913, "disease": "", "pathway": " (bta:767874); (R-BTA-168928); (R-BTA-2029482); (R-BTA-3371497); (R-BTA-3371511); (R-BTA-3371568); (R-BTA-3371571); (R-BTA-399954); (R-BTA-6798695); (R-BTA-844456); (R-BTA-8937144); (R-BTA-8939211); (R-BTA-9013418); (R-BTA-9018519)", "pathway_count": 14, "publication_count": 6, "publication_id_list": "16305752;18682401;21465483;22008953;25153455;29037409", "class_list": "", "function": "Association analysis revealed that the T allele at SNP g.4338T>C of the HSP90AB1 gene improved heat tolerance in cattle. Allele T was 100% in White Lamphun animals, 84% in Mountain cattle, and 18% in Holstein Friesian heifers., [RefSeq, PubMed]; Heat tolerance was assessed in Boran and Nguni cows. Protein levels of HSP90AB1, skin thickness, rectal and skin temperature were higher in the Boran cows than Nguni cows. Breed, age and coat colour did not influence HSP90AB1 concentration., [RefSeq, PubMed]; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10., [UniProtKB, UniProtKB]; Studied the nucleotide polymorphism within the HSP90AB1 gene (SNP g.4338T>C) in Indian breeds of dairy cattle., [RefSeq, PubMed]; The protective effect exerted by HSP90 on eNOS degradation mediated by calpain represents a novel and critical mechanism that assures the reversibility of the intracellular trafficking and activation of the synthase, [RefSeq, PubMed]; This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 and ALK5 interact with heat shock protein 90(HSP90)., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046983 protein dimerization activity;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0034605 cellular response to heat;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q76LV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9XS59-1", "uniprot_id": [ { "id": "S6A15_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9XS59", "type": "external" } ], "mass": 81681.0, "length": 729, "protein_name": "Sodium-dependent neutral amino acid transporter B(0)AT2", "gene_name": "SLC6A15", "organism": "Bovine", "refseq_name": "sodium-dependent neutral amino acid transporter B(0)AT2", "refseq_ac": [ { "id": "NP_851366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851366", "type": "external" } ], "gene_names_uniprotkb": "SLC6A15; B0AT2; NTT73", "gene_names_refseq": "NTT73; SLC6A15", "protein_names_uniprotkb": "Sodium-dependent neutral amino acid transporter B(0)AT2; Sodium- and chloride-dependent neurotransmitter transporter NTT73; Solute carrier family 6 member 15; Transporter v7-3", "protein_names_refseq": "homolog of rat orphan transporter v7-3; orphan sodium- and chloride-dependent neurotransmitter transporter NTT73; sodium-dependent neutral amino acid transporter B(0)AT2", "tax_id": 9913, "disease": "", "pathway": " (bta:281952); (R-BTA-352230); (R-BTA-442660)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10025945", "class_list": "", "function": "Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005298 proline:sodium symporter activity;GO:0005295 neutral L-amino acid:sodium symporter activity;GO:0015657 branched-chain amino acid:sodium symporter activity;GO:0046872 metal ion binding;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015820 L-leucine transport;GO:0015824 proline transport;GO:0015804 neutral amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9XS59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8YXY8-1", "uniprot_id": [ { "id": "AKIR2_BOVIN", "url": "https://www.uniprot.org/uniprot/A8YXY8", "type": "external" } ], "mass": 22510.0, "length": 203, "protein_name": "Akirin-2", "gene_name": "AKIRIN2", "organism": "Bovine", "refseq_name": "akirin-2", "refseq_ac": [ { "id": "NP_001103557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103557", "type": "external" } ], "gene_names_uniprotkb": "AKIRIN2", "gene_names_refseq": "AKIRIN2; Akirin-2; C9H6ORF166", "protein_names_uniprotkb": "Akirin-2", "protein_names_refseq": "akirin-2", "tax_id": 9913, "disease": "", "pathway": " (bta:614292)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23718263;24033432", "class_list": "", "function": "Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (By similarity). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6. Also involved in adaptive immunity by promoting B-cell activation. Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells. Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The c.*188G>A SNP of akirin 2 might be useful as a DNA marker for longissimus muscle area and marbling scores in Korean native cattle., [RefSeq, PubMed]; The findings suggest the presence of inter-allelic interactions among genes affecting the development of beef marbling., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0003712 transcription coregulator activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0017053 transcription repressor complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0021987 cerebral cortex development;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A8YXY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BN35-1", "uniprot_id": [ { "id": "E1BN35_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BN35", "type": "external" } ], "mass": 56050.0, "length": 508, "protein_name": "Cytochrome P450 family 27 subfamily B member 1", "gene_name": "CYP27B1", "organism": "Bovine", "refseq_name": "25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial", "refseq_ac": [ { "id": "NP_001179213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179213", "type": "external" } ], "gene_names_uniprotkb": "CYP27B1", "gene_names_refseq": "CYP27B1", "protein_names_uniprotkb": "Cytochrome P450 family 27 subfamily B member 1", "protein_names_refseq": "25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; cytochrome P450, family 27, subfamily B, polypeptide 1", "tax_id": 9913, "disease": "", "pathway": " (bta:539630); (R-BTA-196791); (R-BTA-211916)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21124742", "class_list": "", "function": "Data show that in tissue and secreted cells from the infected mammary glands, 25-hydroxyvitamin D(3) 1alpha-hydroxylase (1alpha-OHase; CYP27B1) gene expression was significantly increased compared to expression in tissue and cells from the healthy mammary tissue. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0004498 calcidiol 1-monooxygenase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0042359 vitamin D metabolic process;GO:0042369 vitamin D catabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BN35-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9N0E7-1", "uniprot_id": [ { "id": "MOCOS_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9N0E7", "type": "external" } ], "mass": 97205.0, "length": 882, "protein_name": "Molybdenum cofactor sulfurase", "gene_name": "MOCOS", "organism": "Bovine", "refseq_name": "molybdenum cofactor sulfurase", "refseq_ac": [ { "id": "NP_776506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776506", "type": "external" } ], "gene_names_uniprotkb": "MOCOS; MCSU", "gene_names_refseq": "HMCS; MCS; MOCOS", "protein_names_uniprotkb": "Molybdenum cofactor sulfurase; 2.8.1.9; MCS; MOS; MoCo sulfurase; Molybdenum cofactor sulfurtransferase", "protein_names_refseq": "molybdenum cofactor sulfurase", "tax_id": 9913, "disease": "", "pathway": " (bta:281226); (R-BTA-947581)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10801779;19393038;27919260;37675885", "class_list": "", "function": "MOCOS loss of function variant is highly likely to cause the renal syndrome in the affected animals Publication Status: Online-Only, [RefSeq, PubMed]; MOCOS-associated renal syndrome in a Brown Swiss cattle., [RefSeq, PubMed]; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form., [UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1N3A9;G3N1I0", "ec_number_list": [ { "id": "2.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.9", "type": "external" } ], "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0030170 pyridoxal phosphate binding;GO:0016829 lyase activity;GO:0008265 molybdenum cofactor sulfurtransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0043545 molybdopterin cofactor metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9N0E7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BP93-1", "uniprot_id": [ { "id": "E1BP93_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BP93", "type": "external" } ], "mass": 150932.0, "length": 1331, "protein_name": "Nephrocystin-3", "gene_name": "NPHP3", "organism": "Bovine", "refseq_name": "nephrocystin-3", "refseq_ac": [ { "id": "NP_001179081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179081", "type": "external" } ], "gene_names_uniprotkb": "NPHP3", "gene_names_refseq": "NPHP3", "protein_names_uniprotkb": "Nephrocystin-3", "protein_names_refseq": "nephrocystin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:507522); (R-BTA-5624138)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0097546 ciliary base;GO:0097543 ciliary inversin compartment;GO:0097542 ciliary tip", "go_biological_process": "GO:0060993 kidney morphogenesis;GO:0048496 maintenance of animal organ identity;GO:0016055 Wnt signaling pathway;GO:0007368 determination of left/right symmetry;GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BP93-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YDJ8-1", "uniprot_id": [ { "id": "KMT5A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2YDJ8", "type": "external" } ], "mass": 39277.0, "length": 352, "protein_name": "N-lysine methyltransferase KMT5A", "gene_name": "KMT5A", "organism": "Bovine", "refseq_name": "N-lysine methyltransferase KMT5A", "refseq_ac": [ { "id": "NP_001039795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039795", "type": "external" } ], "gene_names_uniprotkb": "KMT5A; SETD8", "gene_names_refseq": "KMT5A; SETD8", "protein_names_uniprotkb": "N-lysine methyltransferase KMT5A; 2.1.1.-; 2.1.1.361; H4-K20-HMTase KMT5A; Histone-lysine N-methyltransferase KMT5A; Lysine-specific methylase 5A; PR-Set7; PR/SET domain-containing protein 07; PR/SET07; SET domain-containing protein 8", "protein_names_refseq": "H4-K20-HMTase KMT5A; H4-K20-HMTase SETD8; N-lysine methyltransferase KMT5A; N-lysine methyltransferase SETD8; PR-Set7; PR/SET domain-containing protein 07; PR/SET07; SET domain containing (lysine methyltransferase) 8; SET domain-containing 8; SET domain-containing protein 8; histone-lysine N-methyltransferase KMT5A; histone-lysine N-methyltransferase SETD8; lysine-specific methylase 5A", "tax_id": 9913, "disease": "", "pathway": " (bta:532622); (R-BTA-2299718); (R-BTA-3214841); (R-BTA-6804760); (R-BTA-9764725)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.4.24.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.71", "type": "external" } ], "go_molecular_function": "GO:0042054 histone methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity;GO:0042799 histone H4K20 methyltransferase activity;GO:0140944 histone H4K20 monomethyltransferase activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005700 polytene chromosome;GO:0005694 chromosome;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2YDJ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MMW7-1", "uniprot_id": [ { "id": "F1MMW7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MMW7", "type": "external" } ], "mass": 54669.0, "length": 492, "protein_name": "Activin receptor type-1C", "gene_name": "ACVR1C", "organism": "Bovine", "refseq_name": "activin receptor type-1C precursor", "refseq_ac": [ { "id": "NP_001179808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179808", "type": "external" } ], "gene_names_uniprotkb": "ACVR1C", "gene_names_refseq": "ACVR1C", "protein_names_uniprotkb": "Activin receptor type-1C; 2.7.11.30; Activin receptor type IC; Activin receptor-like kinase 7", "protein_names_refseq": "activin A receptor, type IC; activin receptor type-1C precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:536380); (R-BTA-1502540)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells. Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004675 transmembrane receptor protein serine/threonine kinase activity;GO:0019838 growth factor binding;GO:0016361 activin receptor activity, type I", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048179 activin receptor complex", "go_biological_process": "GO:0006915 apoptotic process;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0097190 apoptotic signaling pathway;GO:0071363 cellular response to growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MMW7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCV4-1", "uniprot_id": [ { "id": "E1BCV4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCV4", "type": "external" } ], "mass": 195870.0, "length": 1799, "protein_name": "Nuclear pore complex protein Nup98-Nup96", "gene_name": "NUP98", "organism": "Bovine", "refseq_name": "nuclear pore complex protein Nup98-Nup96 isoform X2", "refseq_ac": [ { "id": "XP_002693474", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693474", "type": "external" } ], "gene_names_uniprotkb": "NUP98", "gene_names_refseq": "NUP98", "protein_names_uniprotkb": "Nuclear pore complex protein Nup98-Nup96", "protein_names_refseq": "nuclear pore complex protein Nup98-Nup96 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:540004); (R-BTA-141430); (R-BTA-141444); (R-BTA-159227); (R-BTA-159230); (R-BTA-159231); (R-BTA-159236); (R-BTA-1855170); (R-BTA-1855196); (R-BTA-1855229); (R-BTA-191859); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-3108214); (R-BTA-3232142); (R-BTA-3301854); (R-BTA-3371453); (R-BTA-4085377); (R-BTA-4551638); (R-BTA-4570464); (R-BTA-4615885); (R-BTA-5663220); (R-BTA-9615933); (R-BTA-9648025)", "pathway_count": 24, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore;GO:0008236 serine-type peptidase activity;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0031080 nuclear pore outer ring;GO:0044615 nuclear pore nuclear basket", "go_biological_process": "GO:0006508 proteolysis;GO:0015031 protein transport;GO:0051028 mRNA transport;GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0051292 nuclear pore complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCV4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MG06-1", "uniprot_id": [ { "id": "F1MG06_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MG06", "type": "external" } ], "mass": 151556.0, "length": 1353, "protein_name": "Regulatory associated protein of MTOR complex 1", "gene_name": "RPTOR", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RPTOR", "gene_names_refseq": "", "protein_names_uniprotkb": "Regulatory associated protein of MTOR complex 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1632852); (R-BTA-165159); (R-BTA-166208); (R-BTA-3371571); (R-BTA-380972); (R-BTA-5628897); (R-BTA-8943724); (R-BTA-9639288)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0030295 protein kinase activator activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0031931 TORC1 complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0031929 TOR signaling;GO:0010506 regulation of autophagy;GO:0030307 positive regulation of cell growth;GO:0071333 cellular response to glucose stimulus;GO:0010507 negative regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MG06-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BK87-1", "uniprot_id": [ { "id": "E1BK87_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BK87", "type": "external" } ], "mass": 125110.0, "length": 1115, "protein_name": "Glutamate receptor", "gene_name": "GRIN3A", "organism": "Bovine", "refseq_name": "glutamate receptor ionotropic, NMDA 3A", "refseq_ac": [ { "id": "NP_001178464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178464", "type": "external" } ], "gene_names_uniprotkb": "GRIN3A", "gene_names_refseq": "GRIN3A", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, NMDA 3A", "tax_id": 9913, "disease": "", "pathway": " (bta:100295209)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0004972 NMDA glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0008066 glutamate receptor activity;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0014069 postsynaptic density;GO:0045211 postsynaptic membrane;GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BK87-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9GJS9-1", "uniprot_id": [ { "id": "GLRB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9GJS9", "type": "external" } ], "mass": 56039.0, "length": 497, "protein_name": "Glycine receptor subunit beta", "gene_name": "GLRB", "organism": "Bovine", "refseq_name": "glycine receptor subunit beta precursor", "refseq_ac": [ { "id": "NP_776496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776496", "type": "external" } ], "gene_names_uniprotkb": "GLRB", "gene_names_refseq": "GLRB", "protein_names_uniprotkb": "Glycine receptor subunit beta; Glycine receptor 58 kDa subunit", "protein_names_refseq": "glycine receptor 58 kDa subunit; glycine receptor subunit beta precursor; glycine receptor subunit beta", "tax_id": 9913, "disease": "", "pathway": " (bta:281198); (R-BTA-112314)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11178872", "class_list": "", "function": "Subunit of heteromeric glycine-gated chloride channels. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q08DZ9", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0016933 extracellularly glycine-gated ion channel activity;GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0016594 glycine binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0016935 glycine-gated chloride channel complex;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0001964 startle response;GO:0060012 synaptic transmission, glycinergic;GO:0006811 monoatomic ion transport;GO:0007218 neuropeptide signaling pathway;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9GJS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T005-1", "uniprot_id": [ { "id": "PDLI4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T005", "type": "external" } ], "mass": 35425.0, "length": 331, "protein_name": "PDZ and LIM domain protein 4", "gene_name": "PDLIM4", "organism": "Bovine", "refseq_name": "PDZ and LIM domain protein 4", "refseq_ac": [ { "id": "NP_001029663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029663", "type": "external" } ], "gene_names_uniprotkb": "PDLIM4", "gene_names_refseq": "PDLIM4", "protein_names_uniprotkb": "PDZ and LIM domain protein 4", "protein_names_refseq": "PDZ and LIM domain protein 4", "tax_id": 9913, "disease": "", "pathway": " (bta:515410)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0034777 recycling endosome lumen;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0098976 excitatory chemical synaptic transmission;GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T005-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4JF28-1", "uniprot_id": [ { "id": "IRF3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q4JF28", "type": "external" } ], "mass": 46646.0, "length": 417, "protein_name": "Interferon regulatory factor 3", "gene_name": "IRF3", "organism": "Bovine", "refseq_name": "interferon regulatory factor 3", "refseq_ac": [ { "id": "NP_001025016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025016", "type": "external" } ], "gene_names_uniprotkb": "IRF3", "gene_names_refseq": "IRF3", "protein_names_uniprotkb": "Interferon regulatory factor 3; IRF-3", "protein_names_refseq": "IRF-3; interferon regulatory factor 3", "tax_id": 9913, "disease": "", "pathway": " (bta:516979); (R-BTA-1169408); (R-BTA-1606341); (R-BTA-168928); (R-BTA-3134973); (R-BTA-3270619); (R-BTA-9013973); (R-BTA-918233); (R-BTA-933541); (R-BTA-936440); (R-BTA-936964)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "17531282;21689696;29981712", "class_list": "", "function": "CpBVDV infection causes a marked loss of interferon regulatory factor 3 (IRF-3), a cellular transcription factor that controls interferon synthesis., [RefSeq, PubMed]; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages., [UniProtKB, UniProtKB]; The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 degradation., [RefSeq, PubMed]; These results link the stimulation of the innate immune response observed in 3 NCR-transfected cells to the intracellular type I IFN signaling pathway and suggest the potential use of these molecules for antiviral strategies in cattle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8W7A8;Q45VM9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007166 cell surface receptor signaling pathway;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4JF28-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZK8-1", "uniprot_id": [ { "id": "NHRF1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZK8", "type": "external" } ], "mass": 39603.0, "length": 368, "protein_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1", "gene_name": "NHERF1", "organism": "Bovine", "refseq_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1", "refseq_ac": [ { "id": "NP_001071320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071320", "type": "external" } ], "gene_names_uniprotkb": "NHERF1; NHERF; SLC9A3R1", "gene_names_refseq": "EBP50; NHERF-1; NHERF1; SLC9A3R1", "protein_names_uniprotkb": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1; EBP50; Ezrin-radixin-moesin-binding phosphoprotein 50; NHERF-1; Regulatory cofactor of Na(+)/H(+) exchanger; Sodium-hydrogen exchanger regulatory factor 1; Solute carrier family 9 isoform A3 regulatory factor 1", "protein_names_refseq": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF; SLC9A3 regulator 1; ezrin-radixin-moesin binding phosphoprotein-50; regulatory cofactor of Na(+)/H(+) exchanger; sodium-hydrogen exchanger regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1", "tax_id": 9913, "disease": "", "pathway": " (bta:505242)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22523604", "class_list": "", "function": "Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Study found mainly nuclear localization of EBP50 in interphase cells, and its redistribution to cytoplasm during mitosis parallel with its phosphorylation; PP2A was identified as an interacting protein of EBP50 during pro-, prometa-, meta-, ana-, telophase, and early cytokinesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0050780 dopamine receptor binding;GO:0031800 type 3 metabotropic glutamate receptor binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030033 microvillus assembly;GO:0034635 glutathione transport;GO:0097291 renal phosphate ion absorption;GO:0007009 plasma membrane organization;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SZK8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWX9-1", "uniprot_id": [ { "id": "RAD21_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SWX9", "type": "external" } ], "mass": 71514.0, "length": 630, "protein_name": "Double-strand-break repair protein rad21 homolog", "gene_name": "RAD21", "organism": "Bovine", "refseq_name": "double-strand-break repair protein rad21 homolog", "refseq_ac": [ { "id": "NP_001029889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029889", "type": "external" } ], "gene_names_uniprotkb": "RAD21; SCC1", "gene_names_refseq": "RAD21", "protein_names_uniprotkb": "Double-strand-break repair protein rad21 homolog; 64-kDa carboxy-terminal product", "protein_names_refseq": "RAD21 homolog; double-strand-break repair protein rad21 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:540966); (R-BTA-2467813); (R-BTA-2468052); (R-BTA-2470946); (R-BTA-2500257); (R-BTA-3108214)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression. Binds to and represses APOB gene promoter (By similarity). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May promote apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0030893 meiotic cohesin complex;GO:0000794 condensed nuclear chromosome;GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0006915 apoptotic process;GO:0045841 negative regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWX9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BG94-1", "uniprot_id": [ { "id": "E1BG94_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BG94", "type": "external" } ], "mass": 46677.0, "length": 437, "protein_name": "E2F transcription factor 1", "gene_name": "E2F1", "organism": "Bovine", "refseq_name": "transcription factor E2F1", "refseq_ac": [ { "id": "NP_001193008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193008", "type": "external" } ], "gene_names_uniprotkb": "E2F1", "gene_names_refseq": "E2F1", "protein_names_uniprotkb": "E2F transcription factor 1", "protein_names_refseq": "transcription factor E2F1", "tax_id": 9913, "disease": "", "pathway": " (bta:535369); (R-BTA-68911); (R-BTA-69231)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0070345 negative regulation of fat cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BG94-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T0E7-1", "uniprot_id": [ { "id": "PP1A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T0E7", "type": "external" } ], "mass": 37512.0, "length": 330, "protein_name": "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "gene_name": "PPP1CA", "organism": "Bovine", "refseq_name": "serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "refseq_ac": [ { "id": "NP_001030393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030393", "type": "external" } ], "gene_names_uniprotkb": "PPP1CA", "gene_names_refseq": "PPP1CA", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; 3.1.3.16; PP-1A", "protein_names_refseq": "PP-1A; serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:516175); (R-BTA-180024); (R-BTA-9770562)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H. The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription. PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation. PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (By similarity). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Dephosphorylates CENPA. Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy. Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0046914 transition metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0098641 cadherin binding involved in cell-cell adhesion;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0043247 telomere maintenance in response to DNA damage;GO:0051301 cell division;GO:0005977 glycogen metabolic process;GO:0050821 protein stabilization;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T0E7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95JH2-1", "uniprot_id": [ { "id": "PLCA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q95JH2", "type": "external" } ], "mass": 32005.0, "length": 287, "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase alpha", "gene_name": "AGPAT1", "organism": "Bovine", "refseq_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase alpha precursor", "refseq_ac": [ { "id": "NP_803484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803484", "type": "external" } ], "gene_names_uniprotkb": "AGPAT1", "gene_names_refseq": "AGPAT1; LPAAT", "protein_names_uniprotkb": "1-acyl-sn-glycerol-3-phosphate acyltransferase alpha; 1-AGP acyltransferase 1; 1-AGPAT 1; 1-acylglycerol-3-phosphate O-acyltransferase 1; 2.3.1.51; LPAAT-alpha; Lysophosphatidic acid acyltransferase alpha", "protein_names_refseq": "1-AGP acyltransferase 1; 1-AGPAT 1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha precursor; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha); LPAAT-alpha; lysophosphatidic acid acyltransferase alpha; lysophosphatidic acid-fatty acid transacylase", "tax_id": 9913, "disease": "", "pathway": " (bta:282137); (R-BTA-1483166)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11860120;18385289", "class_list": "", "function": "Activation of lysophosphatidic acid-fatty acid transacylase (LPAAT) is essential but not sufficient for thrombin-induced smooth muscle cell proliferation., [RefSeq, PubMed]; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95MP8", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0001819 positive regulation of cytokine production;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q95JH2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MMD5-1", "uniprot_id": [ { "id": "F1MMD5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MMD5", "type": "external" } ], "mass": 75071.0, "length": 657, "protein_name": "DNA repair protein Ku70", "gene_name": "XRCC6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "XRCC6", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA repair protein Ku70; 4.2.99.18; 5'-deoxyribose-5-phosphate lyase Ku70; 5.6.2.4; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; DNA repair protein XRCC6; X-ray repair cross-complementing protein 6", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5693571); (R-BTA-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": 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"url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003684 damaged DNA binding;GO:0042162 telomeric DNA binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043564 Ku70:Ku80 complex;GO:0005694 chromosome;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006310 DNA recombination;GO:0045087 innate immune response;GO:0000723 telomere maintenance;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0010212 response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MMD5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPF0-1", "uniprot_id": [ { "id": "F1MPF0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPF0", "type": "external" } ], "mass": 212783.0, "length": 1866, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "TRPM7", "organism": "Bovine", "refseq_name": "transient receptor potential cation channel subfamily M member 7", "refseq_ac": [ { "id": "NP_001193095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193095", "type": "external" } ], "gene_names_uniprotkb": "TRPM7", "gene_names_refseq": "TRPM7", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "transient receptor potential cation channel subfamily M member 7", "tax_id": 9913, "disease": "", "pathway": " (bta:514642); (R-BTA-3295583)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", 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"glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005262 calcium channel activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0001726 ruffle", "go_biological_process": "GO:0051262 protein tetramerization;GO:0051289 protein homotetramerization;GO:0006816 calcium ion transport;GO:0098655 monoatomic cation transmembrane transport;GO:0010961 intracellular magnesium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MPF0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BD44-1", "uniprot_id": [ { "id": "BATF_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BD44", "type": "external" } ], "mass": 14079.0, "length": 125, "protein_name": "Basic leucine zipper transcriptional factor ATF-like", "gene_name": "BATF", "organism": "Bovine", "refseq_name": "basic leucine zipper transcriptional factor ATF-like", "refseq_ac": [ { "id": "NP_001193207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193207", "type": "external" } ], "gene_names_uniprotkb": "BATF", "gene_names_refseq": "B-ATF; BATF", "protein_names_uniprotkb": "Basic leucine zipper transcriptional factor ATF-like; B-ATF; B-cell-activating transcription factor", "protein_names_refseq": "B-cell-activating transcription factor; basic leucine zipper transcription factor-like; basic leucine zipper transcriptional factor ATF-like", "tax_id": 9913, "disease": "", "pathway": " (bta:617628)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0060218 hematopoietic stem cell differentiation;GO:0001819 positive regulation of cytokine production;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BD44-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BPM3-1", "uniprot_id": [ { "id": "E1BPM3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BPM3", "type": "external" } ], "mass": 51659.0, "length": 458, "protein_name": "Interleukin-7 receptor subunit alpha", "gene_name": "IL7R", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IL7R", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-7 receptor subunit alpha", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1266695); (R-BTA-8856825); (R-BTA-8856828)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004896 cytokine receptor activity;GO:0004917 interleukin-7 receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0019725 cellular homeostasis;GO:0050830 defense response to Gram-positive bacterium;GO:0030097 hemopoiesis;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BPM3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8PUI7-1", "uniprot_id": [ { "id": "SKA3_BOVIN", "url": "https://www.uniprot.org/uniprot/A8PUI7", "type": "external" } ], "mass": 44762.0, "length": 403, "protein_name": "SKA complex subunit 3", "gene_name": "SKA3", "organism": "Bovine", "refseq_name": "SKA complex subunit 3", "refseq_ac": [ { "id": "NP_001103537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103537", "type": "external" } ], "gene_names_uniprotkb": "SKA3; RAMA1", "gene_names_refseq": "C12H13ORF3; SKA3", "protein_names_uniprotkb": "SKA complex subunit 3; Spindle and kinetochore-associated protein 3", "protein_names_refseq": "SKA complex subunit 3; spindle and kinetochore-associated protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:509921)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces. The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules. The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase. Within the complex, binds microtubules but with a much lower affinity than SKA1. Promotes stability of the polo-like kinase PLK1 protein (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0000776 kinetochore;GO:0005876 spindle microtubule;GO:0072687 meiotic spindle;GO:0072686 mitotic spindle", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A8PUI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SZI5-1", "uniprot_id": [ { "id": "UCP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3SZI5", "type": "external" } ], "mass": 33274.0, "length": 309, "protein_name": "Dicarboxylate carrier UCP2", "gene_name": "UCP2", "organism": "Bovine", "refseq_name": "dicarboxylate carrier UCP2", "refseq_ac": [ { "id": "NP_001028783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028783", "type": "external" } ], "gene_names_uniprotkb": "UCP2; SLC25A8", "gene_names_refseq": "UCP2", "protein_names_uniprotkb": "Dicarboxylate carrier UCP2; Mitochondrial uncoupling protein 2; Solute carrier family 25 member 8; UCP 2", "protein_names_refseq": "UCP 2; dicarboxylate carrier SLC25A8; dicarboxylate carrier UCP2; mitochondrial uncoupling protein 2; solute carrier family 25 member 8; uncoupling protein 2 (mitochondrial, proton carrier)", "tax_id": 9913, "disease": "", "pathway": " (bta:281562); (R-BTA-167826)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15339748;16775060;17785604;18706890", "class_list": "", "function": "A study evaluating the relationships of uncoupling protein 2 and 3 expression, SNP of mitochondrial DNA, and residual feed intake (RFI) in Angus steers selected to have high or low RFI is presented., [RefSeq, PubMed]; Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle lowering the ATP/ADP ratio and reactive oxygen species (ROS) production (By similarity). May mediate inducible proton entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. The proton currents are most likely associated with fatty acid flipping across the inner membrane of mitochondria in a metabolic process regulated by free fatty acids and purine nucleotides (By similarity). Regulates the use of glucose as a source of energy. Required for glucose-induced DRP1-dependent mitochondrial fission and neuron activation in the ventromedial nucleus of the hypothalamus (VMH). This mitochondrial adaptation mechanism modulates the VMH pool of glucose-excited neurons with an impact on systemic glucose homeostasis. Regulates ROS levels and metabolic reprogramming of macrophages during the resolution phase of inflammation. Attenuates ROS production in response to IL33 to preserve the integrity of the Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). Can unidirectionally transport anions including L-malate, L-aspartate, phosphate and chloride ions (By similarity). Does not mediate adaptive thermogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The effect of single nucleotide polymorphisms in 6 genes and their associations with production factors in beef cattle are reported., [RefSeq, PubMed]; These results suggest that UCP2 play an important role of lipid and energy metabolism in mammary epithelial cells., [RefSeq, PubMed]; UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 or UCP2 does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0015297 antiporter activity;GO:0019003 GDP binding;GO:0015078 proton transmembrane transporter activity;GO:0015108 chloride transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0009409 response to cold;GO:0071333 cellular response to glucose stimulus;GO:0001666 response to hypoxia;GO:0051881 regulation of mitochondrial membrane potential;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3SZI5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MD09-1", "uniprot_id": [ { "id": "F1MD09_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MD09", "type": "external" } ], "mass": 29168.0, "length": 255, "protein_name": "Inhibitor of growth protein", "gene_name": "ING4", "organism": "Bovine", "refseq_name": "inhibitor of growth protein 4 isoform X2", "refseq_ac": [ { "id": "XP_024847640", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847640", "type": "external" } ], "gene_names_uniprotkb": "ING4", "gene_names_refseq": "ING4", "protein_names_uniprotkb": "Inhibitor of growth protein", "protein_names_refseq": "inhibitor of growth protein 4 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3214847)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of an histone acetyltransferase complex., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043997 histone H4K12 acetyltransferase activity;GO:0003713 transcription coactivator activity;GO:0043995 histone H4K5 acetyltransferase activity;GO:0043996 histone H4K8 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000123 histone acetyltransferase complex", "go_biological_process": "GO:0006325 chromatin organization;GO:2000278 regulation of DNA biosynthetic process;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MD09-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T165-1", "uniprot_id": [ { "id": "PHB1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T165", "type": "external" } ], "mass": 29804.0, "length": 272, "protein_name": "Prohibitin 1", "gene_name": "PHB1", "organism": "Bovine", "refseq_name": "prohibitin 1", "refseq_ac": [ { "id": "NP_001029744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029744", "type": "external" } ], "gene_names_uniprotkb": "PHB1; PHB", "gene_names_refseq": "PHB1; PHB", "protein_names_uniprotkb": "Prohibitin 1", "protein_names_refseq": "prohibitin 1; prohibitin", "tax_id": 9913, "disease": "", "pathway": " (bta:530409); (R-BTA-5673000); (R-BTA-8949664)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "20832420", "class_list": "", "function": "In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (By similarity). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Regulates mitochondrial respiration activity playing a role in cellular aging. The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses. Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Prohibitin is involved in oxidative stress signaling in the retina and retinal pigment epithelium., [RefSeq, PubMed]; Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (By similarity). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0001851 complement component C3b binding;GO:0001850 complement component C3a binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0032740 positive regulation of interleukin-17 production;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0042113 B cell activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3T165-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5E954-1", "uniprot_id": [ { "id": "DNJA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5E954", "type": "external" } ], "mass": 44882.0, "length": 397, "protein_name": "DnaJ homolog subfamily A member 1", "gene_name": "DNAJA1", "organism": "Bovine", "refseq_name": "dnaJ homolog subfamily A member 1", "refseq_ac": [ { "id": "NP_001015637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015637", "type": "external" } ], "gene_names_uniprotkb": "DNAJA1", "gene_names_refseq": "DNAJA1", "protein_names_uniprotkb": "DnaJ homolog subfamily A member 1", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily A, member 1; dnaJ homolog subfamily A member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:528862); (R-BTA-3371497); (R-BTA-9841251)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16305752;20012712", "class_list": "", "function": "Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity)., [UniProtKB]; Genetic variability and linkage disequilibrium patterns in the bovine DNAJA1 gene are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZU2", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051223 regulation of protein transport;GO:0070585 protein localization to mitochondrion;GO:0007283 spermatogenesis;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5E954-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNZ6-1", "uniprot_id": [ { "id": "E1BNZ6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNZ6", "type": "external" } ], "mass": 125656.0, "length": 1148, "protein_name": "DNA polymerase", "gene_name": "POLD1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "POLD1", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA polymerase; 2.7.7.7", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-110314); (R-BTA-174411); (R-BTA-174414); (R-BTA-174417); (R-BTA-174437); (R-BTA-5358565); (R-BTA-5358606); (R-BTA-5651801); (R-BTA-5656169); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5696397); (R-BTA-5696400); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-69091); (R-BTA-69166); (R-BTA-69183)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0043625 delta DNA polymerase complex;GO:0000109 nucleotide-excision repair complex;GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0006287 base-excision repair, gap-filling;GO:0045004 DNA replication proofreading", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BNZ6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BLS8-1", "uniprot_id": [ { "id": "E1BLS8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BLS8", "type": "external" } ], "mass": 108009.0, "length": 1026, "protein_name": "EMILIN-1", "gene_name": "EMILIN1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EMILIN1", "gene_names_refseq": "", "protein_names_uniprotkb": "EMILIN-1; Elastin microfibril interface-located protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2129379)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0098640 integrin binding involved in cell-matrix adhesion;GO:0030023 extracellular matrix constituent conferring elasticity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034668 integrin alpha4-beta1 complex;GO:1990971 EMILIN complex", "go_biological_process": "GO:0050866 negative regulation of cell activation;GO:1905522 negative regulation of macrophage migration;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BLS8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCF7-1", "uniprot_id": [ { "id": "E1BCF7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCF7", "type": "external" } ], "mass": 34297.0, "length": 331, "protein_name": "Distal-less homeobox 2", "gene_name": "DLX2", "organism": "Bovine", "refseq_name": "homeobox protein DLX-2", "refseq_ac": [ { "id": "NP_001179591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179591", "type": "external" } ], "gene_names_uniprotkb": "DLX2", "gene_names_refseq": "DLX2", "protein_names_uniprotkb": "Distal-less homeobox 2", "protein_names_refseq": "homeobox protein DLX-2", "tax_id": 9913, "disease": "", "pathway": " (bta:528490)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003727 single-stranded RNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0046533 negative regulation of photoreceptor cell differentiation;GO:1902871 positive regulation of amacrine cell differentiation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0048706 embryonic skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCF7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPG7-1", "uniprot_id": [ { "id": "F1MPG7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPG7", "type": "external" } ], "mass": 115869.0, "length": 1025, "protein_name": "RNA cytidine acetyltransferase", "gene_name": "NAT10", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NAT10", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA cytidine acetyltransferase; 18S rRNA cytosine acetyltransferase; 2.3.1.-; N-acetyltransferase 10", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0008080 N-acetyltransferase activity;GO:0051392 tRNA cytidine N4-acetyltransferase activity;GO:1990883 18S rRNA cytidine N-acetyltransferase activity;GO:0005524 ATP binding;GO:0070182 DNA polymerase binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030496 midbody;GO:0005697 telomerase holoenzyme complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0051391 tRNA acetylation;GO:1904812 rRNA acetylation involved in maturation of SSU-rRNA;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MPG7-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9N2J2-1", "uniprot_id": [ { "id": "GPX4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q9N2J2", "type": "external" } ], "mass": 22240.0, "length": 197, "protein_name": "Phospholipid hydroperoxide glutathione peroxidase", "gene_name": "GPX4", "organism": "Bovine", "refseq_name": "phospholipid hydroperoxide glutathione peroxidase isoform A precursor", "refseq_ac": [ { "id": "NP_777195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777195", "type": "external" } ], "gene_names_uniprotkb": "GPX4", "gene_names_refseq": "GPX4; PHGPx", "protein_names_uniprotkb": "Phospholipid hydroperoxide glutathione peroxidase; 1.11.1.12; 1.11.1.9; GPx-4; GSHPx-4; Glutathione peroxidase 4; PHGPx", "protein_names_refseq": "GPx-4; GSHPx-4; glutathione peroxidase 4 (phospholipid hydroperoxidase); phospholipid hydroperoxide glutathione peroxidase isoform A precursor; phospholipid hydroperoxide glutathione peroxidase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:286809); (R-BTA-2142712); (R-BTA-9018676); (R-BTA-9018896); (R-BTA-9020265); (R-BTA-9023661)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "15746255", "class_list": "", "function": "Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity). Can also reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; GPx-4 has an important role in the physiological control of peroxide tone in the bordering cells of the oviductal lumen, [RefSeq, PubMed]; The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development. Disruption of this gene in mouse spermatocytes is associated with male infertility. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004602 glutathione peroxidase activity;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis;GO:0034599 cellular response to oxidative stress;GO:0019372 lipoxygenase pathway;GO:0051258 protein polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9N2J2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5E946-1", "uniprot_id": [ { "id": "PARK7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5E946", "type": "external" } ], "mass": 20035.0, "length": 189, "protein_name": "Parkinson disease protein 7 homolog", "gene_name": "PARK7", "organism": "Bovine", "refseq_name": "Parkinson disease protein 7 homolog", "refseq_ac": [ { "id": "NP_001015572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015572", "type": "external" } ], "gene_names_uniprotkb": "PARK7", "gene_names_refseq": "DJ-1; DJ1; PARK7", "protein_names_uniprotkb": "Parkinson disease protein 7 homolog; 3.1.2.-; 3.5.1.-; 3.5.1.124; DJ-1; Maillard deglycase; Parkinsonism-associated deglycase; Protein DJ-1; Protein/nucleic acid deglycase DJ-1", "protein_names_refseq": "Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7 homolog; maillard deglycase; protein DJ-1; protein deglycase DJ-1; protein/nucleic acid deglycase DJ-1", "tax_id": 9913, "disease": "", "pathway": " (bta:511268); (R-BTA-3899300); (R-BTA-9646399)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. But this function is rebuted by other works. As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin. Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels. Displays a very low glyoxalase activity that may reflect its deglycase activity. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells. In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity. In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZC96", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" } ], "go_molecular_function": "GO:1990422 glyoxalase (glycolic acid-forming) activity;GO:0003713 transcription coactivator activity;GO:0003729 mRNA binding;GO:0005102 signaling receptor binding;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0061727 methylglyoxal catabolic process to lactate;GO:0140041 cellular detoxification of methylglyoxal;GO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5E946-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BIR9-1", "uniprot_id": [ { "id": "E1BIR9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BIR9", "type": "external" } ], "mass": 80227.0, "length": 728, "protein_name": "NAD(+) hydrolase SARM1", "gene_name": "SARM1", "organism": "Bovine", "refseq_name": "NAD(+) hydrolase SARM1", "refseq_ac": [ { "id": "NP_001421982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421982", "type": "external" } ], "gene_names_uniprotkb": "SARM1", "gene_names_refseq": "SARM1", "protein_names_uniprotkb": "NAD(+) hydrolase SARM1; 3.2.2.6; NADP(+) hydrolase SARM1; Sterile alpha and TIR motif-containing protein 1", "protein_names_refseq": "NAD(+) hydrolase SARM1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-166166); (R-BTA-936964); (R-BTA-937041); (R-BTA-937072)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" } ], "go_molecular_function": "GO:0035591 signaling adaptor activity;GO:0003953 NAD+ nucleosidase activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030424 axon;GO:0030425 dendrite;GO:0045202 synapse;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045087 innate immune response;GO:0048678 response to axon injury", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BIR9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7YRV4-1", "uniprot_id": [ { "id": "RO52_BOVIN", "url": "https://www.uniprot.org/uniprot/Q7YRV4", "type": "external" } ], "mass": 54031.0, "length": 469, "protein_name": "E3 ubiquitin-protein ligase TRIM21", "gene_name": "TRIM21", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase TRIM21", "refseq_ac": [ { "id": "NP_872596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_872596", "type": "external" } ], "gene_names_uniprotkb": "TRIM21", "gene_names_refseq": "TRIM21", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM21; 2.3.2.27; 52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; Ro(SS-A); SS-A; Sjoegren syndrome type A antigen; Tripartite motif-containing protein 21", "protein_names_refseq": "52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; 52kD Ro/SSA autoantigen; E3 ubiquitin-protein ligase TRIM21; RING-type E3 ubiquitin transferase TRIM21; SS-A; ro(SS-A); sjoegren syndrome type A antigen; tripartite motif-containing protein 21", "tax_id": 9913, "disease": "", "pathway": " (bta:359715); (R-BTA-3134975); (R-BTA-9755511); (R-BTA-983168)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "14534436;16305752", "class_list": "", "function": "E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by catalyzing polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Also regulates autophagy through FIP200/RB1CC1 ubiquitination and subsequent decreased protein stability. Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI. During viral infection, promotes cell pyroptosis by mediating 'Lys-6'-linked ubiquitination of ISG12a/IFI27, facilitating its translocation into the mitochondria and subsequent CASP3 activation. When up-regulated through the IFN/JAK/STAT signaling pathway, promotes 'Lys-27'-linked ubiquitination of MAVS, leading to the recruitment of TBK1 and up-regulation of innate immunity. Mediates 'Lys-63'-linked polyubiquitination of G3BP1 in response to heat shock, leading to stress granule disassembly., [UniProtKB, UniProtKB, UniProtKB]; The present studies describe the expression cloning of this gene product from a bovine brain microvascular cDNA library., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FV39", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0000932 P-body", "go_biological_process": "GO:0032092 positive regulation of protein binding;GO:0045087 innate immune response;GO:0010508 positive regulation of autophagy;GO:0016567 protein ubiquitination;GO:0045787 positive regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7YRV4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BIS6-1", "uniprot_id": [ { "id": "NR1H2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q5BIS6", "type": "external" } ], "mass": 49988.0, "length": 455, "protein_name": "Oxysterols receptor LXR-beta", "gene_name": "NR1H2", "organism": "Bovine", "refseq_name": "oxysterols receptor LXR-beta", "refseq_ac": [ { "id": "NP_001014883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014883", "type": "external" } ], "gene_names_uniprotkb": "NR1H2; LXRB", "gene_names_refseq": "NR1H2", "protein_names_uniprotkb": "Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor subfamily 1 group H member 2", "protein_names_refseq": "liver X receptor beta; nuclear orphan receptor LXR-beta; oxysterols receptor LXR-beta", "tax_id": 9913, "disease": "", "pathway": " (bta:509622); (R-BTA-383280); (R-BTA-4090294); (R-BTA-8866427); (R-BTA-9029569); (R-BTA-9623433)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (By similarity). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q32KU5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0034191 apolipoprotein A-I receptor binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010875 positive regulation of cholesterol efflux;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BIS6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCQ0-1", "uniprot_id": [ { "id": "E1BCQ0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCQ0", "type": "external" } ], "mass": 36631.0, "length": 318, "protein_name": "Polyprenal reductase", "gene_name": "SRD5A3", "organism": "Bovine", "refseq_name": "polyprenal reductase", "refseq_ac": [ { "id": "NP_001193019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193019", "type": "external" } ], "gene_names_uniprotkb": "SRD5A3", "gene_names_refseq": "SRD5A3", "protein_names_uniprotkb": "Polyprenal reductase; 1.3.1.22; 1.3.1.94", "protein_names_refseq": "polyprenal reductase", "tax_id": 9913, "disease": "", "pathway": " (bta:535834); (R-BTA-193048); (R-BTA-446199)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.22", "type": "external" }, { "id": "1.3.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.94", "type": "external" } ], "go_molecular_function": "GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity;GO:0102389 polyprenol reductase activity;GO:0160198 polyprenal reductase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0016095 polyprenol catabolic process;GO:0043048 dolichyl monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCQ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKM5-1", "uniprot_id": [ { "id": "E1BKM5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKM5", "type": "external" } ], "mass": 107813.0, "length": 987, "protein_name": "ATP-dependent DNA helicase", "gene_name": "RECQL5", "organism": "Bovine", "refseq_name": "ATP-dependent DNA helicase Q5", "refseq_ac": [ { "id": "NP_001179255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179255", "type": "external" } ], "gene_names_uniprotkb": "RECQL5", "gene_names_refseq": "RECQL5", "protein_names_uniprotkb": "ATP-dependent DNA helicase; 5.6.2.4", "protein_names_refseq": "ATP-dependent DNA helicase Q5; RecQ protein-like 5", "tax_id": 9913, "disease": "", "pathway": " (bta:512590)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0097550 transcription preinitiation complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006355 regulation of DNA-templated transcription;GO:0051301 cell division;GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BKM5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7L5-1", "uniprot_id": [ { "id": "FLCN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3B7L5", "type": "external" } ], "mass": 64204.0, "length": 579, "protein_name": "Folliculin", "gene_name": "FLCN", "organism": "Bovine", "refseq_name": "folliculin", "refseq_ac": [ { "id": "NP_001030440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030440", "type": "external" } ], "gene_names_uniprotkb": "FLCN", "gene_names_refseq": "FLCN", "protein_names_uniprotkb": "Folliculin", "protein_names_refseq": "folliculin", "tax_id": 9913, "disease": "", "pathway": " (bta:526652); (R-BTA-9639288)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (By similarity). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (By similarity). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (By similarity). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (By similarity). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (By similarity). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (By similarity). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (By similarity). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (By similarity). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (By similarity). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (By similarity). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0005096 GTPase activator activity;GO:0019899 enzyme binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1901874 negative regulation of post-translational protein modification;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B7L5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6UC88-1", "uniprot_id": [ { "id": "LYVE1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q6UC88", "type": "external" } ], "mass": 35561.0, "length": 322, "protein_name": "Lymphatic vessel endothelial hyaluronic acid receptor 1", "gene_name": "LYVE1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LYVE1; CRSBP1; XLKD1", "gene_names_refseq": "", "protein_names_uniprotkb": "Lymphatic vessel endothelial hyaluronic acid receptor 1; CRSBP-1; Cell surface retention sequence-binding protein 1; Extracellular link domain-containing protein 1; LYVE-1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2142845); (R-BTA-2160916)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12912978", "class_list": "", "function": "Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:12912978). Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005540 hyaluronic acid binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0007155 cell adhesion;GO:0006898 receptor-mediated endocytosis;GO:0030214 hyaluronan catabolic process;GO:0002693 positive regulation of cellular extravasation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6UC88-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SQG8-1", "uniprot_id": [ { "id": "HYAL2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q8SQG8", "type": "external" } ], "mass": 53881.0, "length": 473, "protein_name": "Hyaluronidase-2", "gene_name": "HYAL2", "organism": "Bovine", "refseq_name": "hyaluronidase-2 precursor", "refseq_ac": [ { "id": "NP_776772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776772", "type": "external" } ], "gene_names_uniprotkb": "HYAL2", "gene_names_refseq": "HYAL2", "protein_names_uniprotkb": "Hyaluronidase-2; 3.2.1.35; Hyal-2; Hyaluronoglucosaminidase-2", "protein_names_refseq": "hyal-2; hyaluronidase-2 precursor; hyaluronoglucosaminidase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281838); (R-BTA-2142845); (R-BTA-2160916)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11836391;16305752;23625939;25864644", "class_list": "glycogene;glycosylhydrolase", "function": "CD44 knock-down in bovine and human chondrocytes results in release of bound HYAL2., [RefSeq, PubMed]; Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases. Essential for the breakdown of extracellular matrix hyaluronan., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HYAL2 expression improves the blastocyst rate and embryo quality, an effect which requires CD44 activity and MAPK signaling., [RefSeq, PubMed]; May degrade hyaluronan by analogy to human HYAL2, which is a weak acid-active hyaluronidase. Serves as an entry receptor for jaagsiekte sheep retrovirus in sheep and bovine as well as for enzootic nasal tumor virus in sheep., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.35", "type": "external" } ], "go_molecular_function": "GO:0001618 virus receptor activity;GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity;GO:0005540 hyaluronic acid binding;GO:0004415 hyalurononglucosaminidase activity;GO:0033906 hyaluronoglucuronidase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0010764 negative regulation of fibroblast migration;GO:0071493 cellular response to UV-B;GO:0042117 monocyte activation;GO:0005975 carbohydrate metabolic process;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8SQG8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHX3-1", "uniprot_id": [ { "id": "RBM4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3MHX3", "type": "external" } ], "mass": 40077.0, "length": 362, "protein_name": "RNA-binding protein 4", "gene_name": "RBM4", "organism": "Bovine", "refseq_name": "RNA-binding protein 4", "refseq_ac": [ { "id": "NP_001070478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070478", "type": "external" } ], "gene_names_uniprotkb": "RBM4; RBM4A", "gene_names_refseq": "RBM4", "protein_names_uniprotkb": "RNA-binding protein 4; RNA-binding motif protein 4a; RNA-binding motif protein 4", "protein_names_refseq": "RNA-binding motif protein 4a; RNA-binding protein 4", "tax_id": 9913, "disease": "", "pathway": " (bta:767937)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A5D970", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0097157 pre-mRNA intronic binding;GO:0097158 pre-mRNA intronic pyrimidine-rich binding;GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0002190 cap-independent translational initiation;GO:0032055 negative regulation of translation in response to stress;GO:0006397 mRNA processing;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3MHX3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B9VR26-1", "uniprot_id": [ { "id": "CML1_BOVIN", "url": "https://www.uniprot.org/uniprot/B9VR26", "type": "external" } ], "mass": 40711.0, "length": 362, "protein_name": "Chemerin-like receptor 1", "gene_name": "CMLKR1", "organism": "Bovine", "refseq_name": "chemerin-like receptor 1", "refseq_ac": [ { "id": "NP_001138707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138707", "type": "external" } ], "gene_names_uniprotkb": "CMLKR1", "gene_names_refseq": "CMKLR1; CMLKR1; Cmklr-1", "protein_names_uniprotkb": "Chemerin-like receptor 1; CMKLR-1; Chemokine-like receptor 1", "protein_names_refseq": "chemerin-like receptor 1; chemokine-like receptor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:615411); (R-BTA-373076)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "20399065;30777067", "class_list": "", "function": "Data show that the fat and energy moblization during lactation influences circulating retinoic acid receptor responder protein 2 (RARRES2) levels as well as the expression of RARRES2 and chemokine-like receptor 1 (CMKLR1) in subcutaneous adipose tissue (SAT) and ovarian cells. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004875 complement receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0097003 adipokinetic hormone receptor activity;GO:0097004 adipokinetic hormone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B9VR26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0LZJ1-1", "uniprot_id": [ { "id": "DMRT1_BOVIN", "url": "https://www.uniprot.org/uniprot/C0LZJ1", "type": "external" } ], "mass": 37909.0, "length": 357, "protein_name": "Doublesex and mab-3 related transcription factor 1", "gene_name": "DMRT1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DMRT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Doublesex and mab-3 related transcription factor 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:616245)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19393038;20016168", "class_list": "", "function": "Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1MYB6;Q32LL0", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0046661 male sex differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008344 adult locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "C0LZJ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7D0-1", "uniprot_id": [ { "id": "E1B7D0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7D0", "type": "external" } ], "mass": 100519.0, "length": 922, "protein_name": "Sodium/calcium exchanger 1", "gene_name": "SLC8A2", "organism": "Bovine", "refseq_name": "sodium/calcium exchanger 2 isoform X1", "refseq_ac": [ { "id": "XP_002695230", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695230", "type": "external" } ], "gene_names_uniprotkb": "SLC8A2", "gene_names_refseq": "SLC8A2", "protein_names_uniprotkb": "Sodium/calcium exchanger 1; Na(+)/Ca(2+)-exchange protein 1; Solute carrier family 8 member 1", "protein_names_refseq": "sodium/calcium exchanger 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:535881); (R-BTA-418359); (R-BTA-425561); (R-BTA-5578775)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0005432 calcium:sodium antiporter activity", "go_cellular_component": "GO:0014069 postsynaptic density;GO:0030424 axon;GO:0043679 axon terminus;GO:0098794 postsynapse;GO:0042383 sarcolemma", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0007612 learning;GO:0007613 memory;GO:0070050 neuron cellular homeostasis;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7D0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7H4-1", "uniprot_id": [ { "id": "E1B7H4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7H4", "type": "external" } ], "mass": 103284.0, "length": 948, "protein_name": "Mitogen-activated protein kinase kinase kinase", "gene_name": "MAP3K10", "organism": "Bovine", "refseq_name": "mitogen-activated protein kinase kinase kinase 10", "refseq_ac": [ { "id": "XP_024834856", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834856", "type": "external" } ], "gene_names_uniprotkb": "MAP3K10", "gene_names_refseq": "MAP3K10", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase; 2.7.11.25", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 10", "tax_id": 9913, "disease": "", "pathway": " (bta:781037)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0043425 bHLH transcription factor binding;GO:0004706 JUN kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7H4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7Q7-1", "uniprot_id": [ { "id": "TRIPC_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7Q7", "type": "external" } ], "mass": 220390.0, "length": 1992, "protein_name": "E3 ubiquitin-protein ligase TRIP12", "gene_name": "TRIP12", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase TRIP12", "refseq_ac": [ { "id": "NP_001178132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178132", "type": "external" } ], "gene_names_uniprotkb": "TRIP12", "gene_names_refseq": "TRIP-12; TRIP12", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIP12; 2.3.2.26; HECT-type E3 ubiquitin transferase TRIP12; TR-interacting protein 12; TRIP-12; Thyroid receptor-interacting protein 12", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIP12; HECT-type E3 ubiquitin transferase TRIP12; TR-interacting protein 12; thyroid receptor-interacting protein 12", "tax_id": 9913, "disease": "", "pathway": " (bta:514387); (R-BTA-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5M6", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1B7Q7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7X3-1", "uniprot_id": [ { "id": "R146A_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7X3", "type": "external" } ], "mass": 37543.0, "length": 346, "protein_name": "E3 ubiquitin-protein ligase RNF146-A", "gene_name": "RNF146A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RNF146A", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF146-A; 2.3.2.27; RING finger protein 146-A; RING-type E3 ubiquitin transferase RNF146-A", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0072572 poly-ADP-D-ribose binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7X3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7X9-1", "uniprot_id": [ { "id": "SMRCD_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7X9", "type": "external" } ], "mass": 117639.0, "length": 1029, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "gene_name": "SMARCAD1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SMARCAD1", "gene_names_refseq": "", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1; 3.6.4.-; SMARCAD1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Protein that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Combines the ATP-dependent ability to exchange histones, with the chaperone-like ATP-independent activity to deposit histones and assemble nucleosomes. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A452DJD2", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0035861 site of double-strand break;GO:0000792 heterochromatin", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051304 chromosome separation;GO:0000729 DNA double-strand break processing;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1B7X9-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B801-1", "uniprot_id": [ { "id": "E1B801_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B801", "type": "external" } ], "mass": 170500.0, "length": 1500, "protein_name": "Rho GTPase-activating protein 35", "gene_name": "ARHGAP35", "organism": "Bovine", "refseq_name": "rho GTPase-activating protein 35", "refseq_ac": [ { "id": "NP_001179327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179327", "type": "external" } ], "gene_names_uniprotkb": "ARHGAP35", "gene_names_refseq": "ARHGAP35; GRLF1", "protein_names_uniprotkb": "Rho GTPase-activating protein 35; Glucocorticoid receptor DNA-binding factor 1", "protein_names_refseq": "glucocorticoid receptor DNA binding factor 1; rho GTPase-activating protein 35", "tax_id": 9913, "disease": "", "pathway": " (bta:540310); (R-BTA-416550); (R-BTA-8849471); (R-BTA-8980692); (R-BTA-9013106); (R-BTA-9013148); (R-BTA-9013404); (R-BTA-9013406); (R-BTA-9013408); (R-BTA-9013409); (R-BTA-9013423); (R-BTA-9696264); (R-BTA-9696270); (R-BTA-9696273)", "pathway_count": 14, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0036064 ciliary basal body", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0008064 regulation of actin polymerization or depolymerization;GO:0006351 DNA-templated transcription;GO:0010976 positive regulation of neuron projection development;GO:0051056 regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B801-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B8R5-1", "uniprot_id": [ { "id": "E1B8R5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B8R5", "type": "external" } ], "mass": 142024.0, "length": 1327, "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "TNKS", "organism": "Bovine", "refseq_name": "poly [ADP-ribose] polymerase tankyrase-1", "refseq_ac": [ { "id": "NP_001193089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193089", "type": "external" } ], "gene_names_uniprotkb": "TNKS", "gene_names_refseq": "TNKS", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase; 2.4.2.-; PARP", "protein_names_refseq": "poly [ADP-ribose] polymerase tankyrase-1", "tax_id": 9913, "disease": "", "pathway": " (bta:535030); (R-BTA-201681); (R-BTA-4641257); (R-BTA-5689880); (R-BTA-8948751)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0070198 protein localization to chromosome, telomeric region;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:1904355 positive regulation of telomere capping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B8R5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B8X7-1", "uniprot_id": [ { "id": "E1B8X7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B8X7", "type": "external" } ], "mass": 48426.0, "length": 424, "protein_name": "Bone morphogenetic protein 10", "gene_name": "BMP10", "organism": "Bovine", "refseq_name": "bone morphogenetic protein 10 precursor", "refseq_ac": [ { "id": "NP_001179047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179047", "type": "external" } ], "gene_names_uniprotkb": "BMP10", "gene_names_refseq": "BMP10", "protein_names_uniprotkb": "Bone morphogenetic protein 10", "protein_names_refseq": "bone morphogenetic protein 10 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:538874); (R-BTA-201451); (R-BTA-2129379)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0031433 telethonin binding;GO:0033612 receptor serine/threonine kinase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030018 Z disc", "go_biological_process": "GO:0007155 cell adhesion;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth;GO:0030509 BMP signaling pathway;GO:0010596 negative regulation of endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B8X7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9C0-1", "uniprot_id": [ { "id": "E1B9C0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9C0", "type": "external" } ], "mass": 23864.0, "length": 211, "protein_name": "Ras-related protein Rab", "gene_name": "RAB38", "organism": "Bovine", "refseq_name": "ras-related protein Rab-38", "refseq_ac": [ { "id": "XP_002699093", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699093", "type": "external" } ], "gene_names_uniprotkb": "RAB38", "gene_names_refseq": "RAB38", "protein_names_uniprotkb": "Ras-related protein Rab", "protein_names_refseq": "ras-related protein Rab-38", "tax_id": 9913, "disease": "", "pathway": " (bta:533332); (R-BTA-8873719); (R-BTA-8876198)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The small GTPases Rab are key regulators in vesicle trafficking., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0035651 AP-3 adaptor complex binding;GO:0036461 BLOC-2 complex binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005764 lysosome;GO:0012505 endomembrane system;GO:0042470 melanosome", "go_biological_process": "GO:1903232 melanosome assembly;GO:0090383 phagosome acidification;GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0032438 melanosome organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9C0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9N7-1", "uniprot_id": [ { "id": "E1B9N7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9N7", "type": "external" } ], "mass": 154916.0, "length": 1366, "protein_name": "ATP-dependent RNA helicase DHX29", "gene_name": "DHX29", "organism": "Bovine", "refseq_name": "ATP-dependent RNA helicase DHX29", "refseq_ac": [ { "id": "NP_001193063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193063", "type": "external" } ], "gene_names_uniprotkb": "DHX29", "gene_names_refseq": "DHX29", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX29; 3.6.4.13; DEAH box protein 29", "protein_names_refseq": "ATP-dependent RNA helicase DHX29; DEAH (Asp-Glu-Ala-His) box polypeptide 29; DEAH-box helicase 29", "tax_id": 9913, "disease": "", "pathway": " (bta:512470)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, 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"https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0004520 DNA endonuclease activity;GO:0004386 helicase activity", "go_cellular_component": "GO:0043596 nuclear replication fork", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0009411 response to UV;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BB03-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BBE2-1", "uniprot_id": [ { "id": "E1BBE2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BBE2", "type": "external" } ], "mass": 18973.0, "length": 167, "protein_name": "Proepiregulin", "gene_name": "EREG", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EREG", "gene_names_refseq": "", "protein_names_uniprotkb": "Proepiregulin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1227986); (R-BTA-1236394); (R-BTA-1250196); (R-BTA-1250342); (R-BTA-1250347); (R-BTA-1257604); (R-BTA-177929); (R-BTA-179812); (R-BTA-180292); (R-BTA-180336); (R-BTA-182971); (R-BTA-1963640); (R-BTA-1963642); (R-BTA-212718); (R-BTA-5673001); (R-BTA-6785631); (R-BTA-6811558); (R-BTA-8847993); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-8863795); (R-BTA-9009391)", "pathway_count": 22, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007267 cell-cell signaling;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BBE2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BBG2-1", "uniprot_id": [ { "id": "MILK1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BBG2", "type": "external" } ], "mass": 92095.0, "length": 853, "protein_name": "MICAL-like protein 1", "gene_name": "MICALL1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MICALL1", "gene_names_refseq": "", "protein_names_uniprotkb": "MICAL-like protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "19393038;19864458;20801876;23596323", "class_list": "", "function": "Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane. Also involved in cargo protein delivery to the plasma membrane. Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (By similarity). May indirectly play a role in neurite outgrowth (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0008093 cytoskeletal anchor activity;GO:0031267 small GTPase binding;GO:0070300 phosphatidic acid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0031902 late endosome membrane;GO:0055038 recycling endosome membrane;GO:0005770 late endosome", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0031175 neuron projection development;GO:0006612 protein targeting to membrane;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E1BBG2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BBN3-1", "uniprot_id": [ { "id": "E1BBN3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BBN3", "type": "external" } ], "mass": 48231.0, "length": 431, "protein_name": "Growth/differentiation factor 2", "gene_name": "GDF2", "organism": "Bovine", "refseq_name": "growth/differentiation factor 2 precursor", "refseq_ac": [ { "id": "NP_001179349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179349", "type": "external" } ], "gene_names_uniprotkb": "GDF2", "gene_names_refseq": "GDF2", "protein_names_uniprotkb": "Growth/differentiation factor 2; Bone morphogenetic protein 9", "protein_names_refseq": "growth/differentiation factor 2 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:540384); (R-BTA-201451)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001570 vasculogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006879 intracellular iron ion homeostasis;GO:0045766 positive regulation of angiogenesis;GO:0001937 negative regulation of endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BBN3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BBQ5-1", "uniprot_id": [ { "id": "E1BBQ5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BBQ5", "type": "external" } ], "mass": 30886.0, "length": 285, "protein_name": "Pancreas/duodenum homeobox protein 1", "gene_name": "PDX1", "organism": "Bovine", "refseq_name": "pancreas/duodenum homeobox protein 1", "refseq_ac": [ { "id": "NP_001179065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179065", "type": "external" } ], "gene_names_uniprotkb": "PDX1", "gene_names_refseq": "PDX1", "protein_names_uniprotkb": "Pancreas/duodenum homeobox protein 1; Insulin promoter factor 1", "protein_names_refseq": "pancreas/duodenum homeobox protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:538927)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0032024 positive regulation of insulin secretion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0003309 type B pancreatic cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BBQ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BBR7-1", "uniprot_id": [ { "id": "E1BBR7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BBR7", "type": "external" } ], "mass": 31580.0, "length": 269, "protein_name": "Elongation of very long chain fatty acids protein 3", "gene_name": "ELOVL3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ELOVL3", "gene_names_refseq": "", "protein_names_uniprotkb": "Elongation of very long chain fatty acids protein 3; 2.3.1.199; 3-keto acyl-CoA synthase ELOVL3; ELOVL FA elongase 3; ELOVL fatty acid elongase 3; Very long chain 3-ketoacyl-CoA synthase 3; Very long chain 3-oxoacyl-CoA synthase 3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2046105); (R-BTA-2046106); (R-BTA-75876)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" } ], "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid;GO:0034626 fatty acid elongation, polyunsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BBR7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BBZ5-1", "uniprot_id": [ { "id": "E1BBZ5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BBZ5", "type": "external" } ], "mass": 127904.0, "length": 1151, "protein_name": "Zinc finger protein ZFPM2", "gene_name": "ZFPM2", "organism": "Bovine", "refseq_name": "LOW QUALITY PROTEIN: zinc finger protein ZFPM2", "refseq_ac": [ { "id": "XP_003586950", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586950", "type": "external" } ], "gene_names_uniprotkb": "ZFPM2", "gene_names_refseq": "ZFPM2", "protein_names_uniprotkb": "Zinc finger protein ZFPM2; Friend of GATA protein 2; Zinc finger protein multitype 2", "protein_names_refseq": "LOW QUALITY PROTEIN: zinc finger protein ZFPM2", "tax_id": 9913, "disease": "", "pathway": " (bta:784747); (R-BTA-983231)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BBZ5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BD59-1", "uniprot_id": [ { "id": "TRI56_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BD59", "type": "external" } ], "mass": 79152.0, "length": 732, "protein_name": "E3 ubiquitin-protein ligase TRIM56", "gene_name": "TRIM56", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TRIM56", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM56; 2.3.2.27; Tripartite motif-containing protein 56", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21289118", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (By similarity). Restricts bovine viral diarrhea virus (BVDV) replication (PubMed:21289118)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0070534 protein K63-linked ubiquitination;GO:0060340 positive regulation of type I interferon-mediated signaling pathway;GO:0032728 positive regulation of interferon-beta production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BD59-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BDC5-1", "uniprot_id": [ { "id": "E1BDC5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BDC5", "type": "external" } ], "mass": 95915.0, "length": 858, "protein_name": "Potassium voltage-gated channel subfamily B member 1", "gene_name": "KCNB1", "organism": "Bovine", "refseq_name": "potassium voltage-gated channel subfamily B member 1", "refseq_ac": [ { "id": "NP_001179198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179198", "type": "external" } ], "gene_names_uniprotkb": "KCNB1", "gene_names_refseq": "KCNB1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel subunit Kv2.1", "protein_names_refseq": "potassium voltage-gated channel subfamily B member 1; potassium voltage-gated channel, Shab-related subfamily, member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:539528); (R-BTA-1296072); (R-BTA-381676)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0030424 axon;GO:0043204 perikaryon;GO:0045211 postsynaptic membrane;GO:0008076 voltage-gated potassium channel complex;GO:0042383 sarcolemma", "go_biological_process": "GO:0098900 regulation of action potential;GO:0051260 protein homooligomerization;GO:0071333 cellular response to glucose stimulus;GO:0001508 action potential;GO:0046676 negative regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BDC5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BDF2-1", "uniprot_id": [ { "id": "SHRPN_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BDF2", "type": "external" } ], "mass": 43394.0, "length": 409, "protein_name": "Sharpin", "gene_name": "SHARPIN", "organism": "Bovine", "refseq_name": "sharpin", "refseq_ac": [ { "id": "NP_001103236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103236", "type": "external" } ], "gene_names_uniprotkb": "SHARPIN", "gene_names_refseq": "SHARPIN", "protein_names_uniprotkb": "Sharpin; Shank-associated RH domain-interacting protein", "protein_names_refseq": "shank-associated RH domain-interacting protein; sharpin", "tax_id": 9913, "disease": "", "pathway": " (bta:512499); (R-BTA-5357786); (R-BTA-5357905); (R-BTA-5357956)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin. The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0004842 ubiquitin-protein transferase activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0071797 LUBAC complex", "go_biological_process": "GO:0097039 protein linear polyubiquitination;GO:2000348 regulation of CD40 signaling pathway;GO:0050728 negative regulation of inflammatory response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BDF2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BDH9-1", "uniprot_id": [ { "id": "E1BDH9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BDH9", "type": "external" } ], "mass": 162506.0, "length": 1451, "protein_name": "protein-tyrosine-phosphatase", "gene_name": "PTPRT", "organism": "Bovine", "refseq_name": "receptor-type tyrosine-protein phosphatase T isoform X7", "refseq_ac": [ { "id": "XP_024857026", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857026", "type": "external" } ], "gene_names_uniprotkb": "PTPRT", "gene_names_refseq": "PTPRT", "protein_names_uniprotkb": "protein-tyrosine-phosphatase; 3.1.3.48", "protein_names_refseq": "receptor-type tyrosine-protein phosphatase T isoform X7", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0042803 protein homodimerization activity;GO:0051393 alpha-actinin binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030336 negative regulation of cell migration;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0071354 cellular response to interleukin-6;GO:1904893 negative regulation of receptor signaling pathway via STAT", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BDH9-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BE02-1", "uniprot_id": [ { "id": "E2F7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BE02", "type": "external" } ], "mass": 99229.0, "length": 911, "protein_name": "Transcription factor E2F7", "gene_name": "E2F7", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "E2F7", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor E2F7; E2F-7", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:526129); (R-BTA-6804116)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001217 DNA-binding transcription repressor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex;GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0032877 positive regulation of DNA endoreduplication;GO:0060718 chorionic trophoblast cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BE02-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true } ]